ArrestinDb

Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	AssayType	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	2274	3173	58	None	-10	36	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4917	3173	58	None	-10	36	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	7279	3173	58	None	-10	36	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL728	3173	58	None	-10	36	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00433	3173	58	None	-10	36	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	2470	3653	50	None	-38018	23	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3300	3653	50	None	-38018	23	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	5265	3653	50	None	-38018	23	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	99	3653	50	None	-38018	23	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL267930	3653	50	None	-38018	23	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3081361	93934	123	None	1	14	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
	CHEMBL24828	93934	123	None	1	14	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
	214	3860	58	None	-31	28	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	2740	3860	58	None	-31	28	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	5566	3860	58	None	-31	28	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	66064	3860	58	None	-31	28	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL422	3860	58	None	-31	28	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00831	3860	58	None	-31	28	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	242	470	124	None	-97	33	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	34	470	124	None	-97	33	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795	470	124	None	-97	33	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL1112	470	124	None	-97	33	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB01238	470	124	None	-97	33	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	2393	3334	82	None	-2041	9	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	5078	3334	82	None	-2041	9	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	51	3334	82	None	-2041	9	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	CHEMBL905	3334	82	None	-2041	9	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	DB00953	3334	82	None	-2041	9	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	3547	141373	71	None	-3	8	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	2	1	4	1.2	O=S(=O)(c1cccc2cnccc12)N1CCCNCC1	10.1038/s41467-023-40064-9
	CHEMBL38380	141373	71	None	-3	8	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	2	1	4	1.2	O=S(=O)(c1cccc2cnccc12)N1CCCNCC1	10.1038/s41467-023-40064-9
	CHEMBL541388	141373	71	None	-3	8	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	2	1	4	1.2	O=S(=O)(c1cccc2cnccc12)N1CCCNCC1	10.1038/s41467-023-40064-9
	71398	106439	44	None	-3235	14	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	5	4	4	3.6	C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1	10.1038/s41467-023-40064-9
	CHEMBL313972	106439	44	None	-3235	14	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	5	4	4	3.6	C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1	10.1038/s41467-023-40064-9
	68617	205527	62	None	-66	30	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1709	205527	62	None	-66	30	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL809	205527	62	None	-66	30	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	367	3824	12	None	-1548	8	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	5487427	3824	12	None	-1548	8	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	8592	3824	12	None	-1548	8	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	CHEMBL1900528	3824	12	None	-1548	8	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	CHEMBL3305968	3824	12	None	-1548	8	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	CHEMBL4650755	3824	12	None	-1548	8	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	DB01409	3824	12	None	-1548	8	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	168871	89130	14	None	-1949	13	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	CHEMBL2365712	89130	14	None	-1949	13	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	2771	195017	74	None	-25	16	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	CHEMBL1200781	195017	74	None	-25	16	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	CHEMBL549	195017	74	None	-25	16	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	191	403	98	None	-21	36	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	201	403	98	None	-21	36	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	2170	403	98	None	-21	36	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	CHEMBL1113	403	98	None	-21	36	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	DB00543	403	98	None	-21	36	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	1400	1957	70	None	1	16	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	3658	1957	70	None	1	16	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	7199	1957	70	None	1	16	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	91513	1957	70	None	1	16	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL896	1957	70	None	1	16	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	DB00557	1957	70	None	1	16	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	146570	43454	67	None	1	7	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	5	0	3	3.8	CN(C)CCC[C@@]1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	CHEMBL1508	43454	67	None	1	7	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	5	0	3	3.8	CN(C)CCC[C@@]1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	1210	918	51	None	-2	22	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	1213	918	51	None	-2	22	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	2725	918	51	None	-2	22	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	33036	918	51	None	-2	22	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	4411	918	51	None	-2	22	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	616	918	51	None	-2	22	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	6976	918	51	None	-2	22	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	716121	918	51	None	-2	22	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL1201353	918	51	None	-2	22	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL1554789	918	51	None	-2	22	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL505	918	51	None	-2	22	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	DB01114	918	51	None	-2	22	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	DB13679	918	51	None	-2	22	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	100	3805	58	None	-33	38	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	2637	3805	58	None	-33	38	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	5452	3805	58	None	-33	38	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	CHEMBL479	3805	58	None	-33	38	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	DB00679	3805	58	None	-33	38	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	16351	102730	47	None	-18	17	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL304902	102730	47	None	-18	17	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	213	3853	55	None	-79	22	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	2717	3853	55	None	-79	22	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	5533	3853	55	None	-79	22	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	CHEMBL621	3853	55	None	-79	22	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	DB00656	3853	55	None	-79	22	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	4640	78266	30	None	-9	11	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	379	6	1	4	3.9	COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC	10.1038/s41467-023-40064-9
	CHEMBL2107011	78266	30	None	-9	11	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	379	6	1	4	3.9	COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC	10.1038/s41467-023-40064-9
	19861	207523	50	None	3	10	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL946	207523	50	None	3	10	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
	2220	3134	82	None	-6	17	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	27400	3134	82	None	-6	17	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	93	3134	82	None	-6	17	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	CHEMBL294951	3134	82	None	-6	17	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	DB06153	3134	82	None	-6	17	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	1385580	29276	76	None	-18	19	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	4615	29276	76	None	-18	19	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL13828	29276	76	None	-18	19	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	2470	3653	50	None	-38018	23	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3300	3653	50	None	-38018	23	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	5265	3653	50	None	-38018	23	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	99	3653	50	None	-38018	23	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL267930	3653	50	None	-38018	23	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	2601	3780	33	None	-1288	17	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	443951	3780	33	None	-1288	17	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	56	3780	33	None	-1288	17	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	CHEMBL73151	3780	33	None	-1288	17	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	DB13399	3780	33	None	-1288	17	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	2218	15283	23	None	-3	12	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	8	0	2	4.4	CCN(CC)CCCN(c1ccccc1)C1Cc2ccccc2C1	10.1038/s41467-023-40064-9
	CHEMBL1213033	15283	23	None	-3	12	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	8	0	2	4.4	CCN(CC)CCCN(c1ccccc1)C1Cc2ccccc2C1	10.1038/s41467-023-40064-9
	21722	17992	31	None	-1	21	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	10.1038/s41467-023-40064-9
	CHEMBL126224	17992	31	None	-1	21	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	10.1038/s41467-023-40064-9
	2247	505	81	None	-4	42	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	249	505	81	None	-4	42	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	2603	505	81	None	-4	42	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	CHEMBL296419	505	81	None	-4	42	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	DB00637	505	81	None	-4	42	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	2333	142335	97	None	-7	14	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	CHEMBL388590	142335	97	None	-7	14	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HRH1 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	10042467	1426	1	None	-1	2	Guinea pig	6.9	pEC50	=	6.9	Functional	Effective concentration for agonism activity in Endothelium-Denuded guinea pig aortic segmentEffective concentration for agonism activity in Endothelium-Denuded guinea pig aortic segment	ChEMBL	333	8	1	2	4.3	CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C	10.1021/jm991056a
	1203	1426	1	None	-1	2	Guinea pig	6.9	pEC50	=	6.9	Functional	Effective concentration for agonism activity in Endothelium-Denuded guinea pig aortic segmentEffective concentration for agonism activity in Endothelium-Denuded guinea pig aortic segment	ChEMBL	333	8	1	2	4.3	CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C	10.1021/jm991056a
	CHEMBL11553	1426	1	None	-1	2	Guinea pig	6.9	pEC50	=	6.9	Functional	Effective concentration for agonism activity in Endothelium-Denuded guinea pig aortic segmentEffective concentration for agonism activity in Endothelium-Denuded guinea pig aortic segment	ChEMBL	333	8	1	2	4.3	CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C	10.1021/jm991056a
	10689833	12766	0	None	-4	2	Rat	5.9	pEC50	=	5.9	Functional	Effective concentration for agonism activity in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619Effective concentration for agonism activity in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619	ChEMBL	359	8	1	2	4.8	c1ccc(C(CCc2nc(CCN3CCCC3)c[nH]2)c2ccccc2)cc1	10.1021/jm991056a
	CHEMBL11879	12766	0	None	-4	2	Rat	5.9	pEC50	=	5.9	Functional	Effective concentration for agonism activity in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619Effective concentration for agonism activity in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619	ChEMBL	359	8	1	2	4.8	c1ccc(C(CCc2nc(CCN3CCCC3)c[nH]2)c2ccccc2)cc1	10.1021/jm991056a
	11791817	98303	0	None	-1	2	Guinea pig	6.8	pEC50	=	6.8	Functional	Effective concentration for agonist activity in guinea pig ileum whole segmentEffective concentration for agonist activity in guinea pig ileum whole segment	ChEMBL	345	9	2	2	4.5	c1ccc(C(CCc2nc(CCNC3CC3)c[nH]2)c2ccccc2)cc1	10.1021/jm991056a
	CHEMBL274831	98303	0	None	-1	2	Guinea pig	6.8	pEC50	=	6.8	Functional	Effective concentration for agonist activity in guinea pig ileum whole segmentEffective concentration for agonist activity in guinea pig ileum whole segment	ChEMBL	345	9	2	2	4.5	c1ccc(C(CCc2nc(CCNC3CC3)c[nH]2)c2ccccc2)cc1	10.1021/jm991056a
	10403687	2511	3	None	-1	2	Rat	6.8	pEC50	=	6.8	Functional	Effective concentration for agonism activity in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619Effective concentration for agonism activity in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	1205	2511	3	None	-1	2	Rat	6.8	pEC50	=	6.8	Functional	Effective concentration for agonism activity in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619Effective concentration for agonism activity in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	CHEMBL275035	2511	3	None	-1	2	Rat	6.8	pEC50	=	6.8	Functional	Effective concentration for agonism activity in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619Effective concentration for agonism activity in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	1269	121	41	None	-354	6	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase assayAgonist activity at human histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase assay	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1021/jm900526h
	37463	121	41	None	-354	6	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase assayAgonist activity at human histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase assay	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1021/jm900526h
	CHEMBL275443	121	41	None	-354	6	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase assayAgonist activity at human histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase assay	ChEMBL	125	2	2	2	0.2	Cc1c(CCN)nc[nH]1	10.1021/jm900526h
	126688	404	33	None	-57	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay	ChEMBL	157	2	2	4	0.5	NCCc1sc(nc1C)N	10.1016/j.bmcl.2010.10.041
	4025	404	33	None	-57	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay	ChEMBL	157	2	2	4	0.5	NCCc1sc(nc1C)N	10.1016/j.bmcl.2010.10.041
	CHEMBL293762	404	33	None	-57	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay	ChEMBL	157	2	2	4	0.5	NCCc1sc(nc1C)N	10.1016/j.bmcl.2010.10.041
	11617365	74275	0	None	-	1	Guinea pig	5.8	pEC50	=	5.8	Functional	Agonist activity at histamine H1 receptor in guinea pig ileumAgonist activity at histamine H1 receptor in guinea pig ileum	ChEMBL	319	7	2	3	3.3	NCCc1c[nH]c(C(=O)CC(c2ccccc2)c2ccccc2)n1	10.1016/j.bmcl.2005.10.030
	CHEMBL202371	74275	0	None	-	1	Guinea pig	5.8	pEC50	=	5.8	Functional	Agonist activity at histamine H1 receptor in guinea pig ileumAgonist activity at histamine H1 receptor in guinea pig ileum	ChEMBL	319	7	2	3	3.3	NCCc1c[nH]c(C(=O)CC(c2ccccc2)c2ccccc2)n1	10.1016/j.bmcl.2005.10.030
	10042467	1426	1	None	1	2	Rat	6.8	pEC50	=	6.8	Functional	Effective concentration for agonism activity in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619Effective concentration for agonism activity in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619	ChEMBL	333	8	1	2	4.3	CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C	10.1021/jm991056a
	1203	1426	1	None	1	2	Rat	6.8	pEC50	=	6.8	Functional	Effective concentration for agonism activity in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619Effective concentration for agonism activity in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619	ChEMBL	333	8	1	2	4.3	CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C	10.1021/jm991056a
	CHEMBL11553	1426	1	None	1	2	Rat	6.8	pEC50	=	6.8	Functional	Effective concentration for agonism activity in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619Effective concentration for agonism activity in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619	ChEMBL	333	8	1	2	4.3	CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C	10.1021/jm991056a
	10447834	1933	4	None	2	3	Guinea pig	6.7	pEC50	=	6.7	Functional	Effective concentration for agonist activity in guinea pig ileum whole segmentEffective concentration for agonist activity in guinea pig ileum whole segment	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	4026	1933	4	None	2	3	Guinea pig	6.7	pEC50	=	6.7	Functional	Effective concentration for agonist activity in guinea pig ileum whole segmentEffective concentration for agonist activity in guinea pig ileum whole segment	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	CHEMBL275507	1933	4	None	2	3	Guinea pig	6.7	pEC50	=	6.7	Functional	Effective concentration for agonist activity in guinea pig ileum whole segmentEffective concentration for agonist activity in guinea pig ileum whole segment	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	1204	1932	119	None	-4	10	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase assayAgonist activity at human histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm900526h
	1247	1932	119	None	-4	10	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase assayAgonist activity at human histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm900526h
	1375	1932	119	None	-4	10	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase assayAgonist activity at human histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm900526h
	774	1932	119	None	-4	10	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase assayAgonist activity at human histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm900526h
	CHEMBL90	1932	119	None	-4	10	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase assayAgonist activity at human histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm900526h
	DB05381	1932	119	None	-4	10	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase assayAgonist activity at human histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm900526h
	10447834	1933	4	None	2	3	Guinea pig	5.7	pEC50	=	5.7	Functional	Effective concentration for agonism activity in Endothelium-Denuded guinea pig aortic segmentEffective concentration for agonism activity in Endothelium-Denuded guinea pig aortic segment	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	4026	1933	4	None	2	3	Guinea pig	5.7	pEC50	=	5.7	Functional	Effective concentration for agonism activity in Endothelium-Denuded guinea pig aortic segmentEffective concentration for agonism activity in Endothelium-Denuded guinea pig aortic segment	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	CHEMBL275507	1933	4	None	2	3	Guinea pig	5.7	pEC50	=	5.7	Functional	Effective concentration for agonism activity in Endothelium-Denuded guinea pig aortic segmentEffective concentration for agonism activity in Endothelium-Denuded guinea pig aortic segment	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	1204	1932	119	None	-3	10	Guinea pig	6.7	pEC50	=	6.7	Functional	Agonist activity at histamine H1 receptor in guinea pig ileumAgonist activity at histamine H1 receptor in guinea pig ileum	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2005.10.030
	1247	1932	119	None	-3	10	Guinea pig	6.7	pEC50	=	6.7	Functional	Agonist activity at histamine H1 receptor in guinea pig ileumAgonist activity at histamine H1 receptor in guinea pig ileum	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2005.10.030
	1375	1932	119	None	-3	10	Guinea pig	6.7	pEC50	=	6.7	Functional	Agonist activity at histamine H1 receptor in guinea pig ileumAgonist activity at histamine H1 receptor in guinea pig ileum	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2005.10.030
	774	1932	119	None	-3	10	Guinea pig	6.7	pEC50	=	6.7	Functional	Agonist activity at histamine H1 receptor in guinea pig ileumAgonist activity at histamine H1 receptor in guinea pig ileum	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2005.10.030
	CHEMBL90	1932	119	None	-3	10	Guinea pig	6.7	pEC50	=	6.7	Functional	Agonist activity at histamine H1 receptor in guinea pig ileumAgonist activity at histamine H1 receptor in guinea pig ileum	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2005.10.030
	DB05381	1932	119	None	-3	10	Guinea pig	6.7	pEC50	=	6.7	Functional	Agonist activity at histamine H1 receptor in guinea pig ileumAgonist activity at histamine H1 receptor in guinea pig ileum	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2005.10.030
	1194	45	3	None	50	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay	ChEMBL	265	3	2	2	2.3	NCCc1cnc([nH]1)c1cccc(c1)Br	10.1016/j.bmcl.2010.10.041
	23786499	45	3	None	50	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay	ChEMBL	265	3	2	2	2.3	NCCc1cnc([nH]1)c1cccc(c1)Br	10.1016/j.bmcl.2010.10.041
	CHEMBL26116	45	3	None	50	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay	ChEMBL	265	3	2	2	2.3	NCCc1cnc([nH]1)c1cccc(c1)Br	10.1016/j.bmcl.2010.10.041
	1204	1932	119	None	-4	10	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	1247	1932	119	None	-4	10	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	1375	1932	119	None	-4	10	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	774	1932	119	None	-4	10	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	CHEMBL90	1932	119	None	-4	10	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	DB05381	1932	119	None	-4	10	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.10.041
	11791817	98303	0	None	-1	2	Guinea pig	5.6	pEC50	=	5.6	Functional	Effective concentration for agonism activity in endothelium-denuded guinea pig aortic segmentEffective concentration for agonism activity in endothelium-denuded guinea pig aortic segment	ChEMBL	345	9	2	2	4.5	c1ccc(C(CCc2nc(CCNC3CC3)c[nH]2)c2ccccc2)cc1	10.1021/jm991056a
	CHEMBL274831	98303	0	None	-1	2	Guinea pig	5.6	pEC50	=	5.6	Functional	Effective concentration for agonism activity in endothelium-denuded guinea pig aortic segmentEffective concentration for agonism activity in endothelium-denuded guinea pig aortic segment	ChEMBL	345	9	2	2	4.5	c1ccc(C(CCc2nc(CCNC3CC3)c[nH]2)c2ccccc2)cc1	10.1021/jm991056a
	5310982	93612	4	None	3	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay	ChEMBL	255	3	2	2	2.6	NCCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1	10.1016/j.bmcl.2010.10.041
	CHEMBL24665	93612	4	None	3	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay	ChEMBL	255	3	2	2	2.6	NCCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1	10.1016/j.bmcl.2010.10.041
	44267376	10221	1	None	-	1	Guinea pig	5.6	pEC50	=	5.6	Functional	Effective concentration for agonist activity in guinea pig ileum whole segmentEffective concentration for agonist activity in guinea pig ileum whole segment	ChEMBL	277	5	2	2	3.1	NCCc1c[nH]c(C(c2ccccc2)c2ccccc2)n1	10.1021/jm991056a
	CHEMBL11603	10221	1	None	-	1	Guinea pig	5.6	pEC50	=	5.6	Functional	Effective concentration for agonist activity in guinea pig ileum whole segmentEffective concentration for agonist activity in guinea pig ileum whole segment	ChEMBL	277	5	2	2	3.1	NCCc1c[nH]c(C(c2ccccc2)c2ccccc2)n1	10.1021/jm991056a
	10689833	12766	0	None	4	2	Guinea pig	6.5	pEC50	=	6.5	Functional	Effective concentration for agonist activity in guinea pig ileum whole segmentEffective concentration for agonist activity in guinea pig ileum whole segment	ChEMBL	359	8	1	2	4.8	c1ccc(C(CCc2nc(CCN3CCCC3)c[nH]2)c2ccccc2)cc1	10.1021/jm991056a
	CHEMBL11879	12766	0	None	4	2	Guinea pig	6.5	pEC50	=	6.5	Functional	Effective concentration for agonist activity in guinea pig ileum whole segmentEffective concentration for agonist activity in guinea pig ileum whole segment	ChEMBL	359	8	1	2	4.8	c1ccc(C(CCc2nc(CCN3CCCC3)c[nH]2)c2ccccc2)cc1	10.1021/jm991056a
	10688111	10040	1	None	2	2	Guinea pig	6.5	pEC50	=	6.5	Functional	Effective concentration for agonist activity in guinea pig ileum whole segmentEffective concentration for agonist activity in guinea pig ileum whole segment	ChEMBL	333	9	2	2	4.3	CCNCCc1c[nH]c(CCC(c2ccccc2)c2ccccc2)n1	10.1021/jm991056a
	CHEMBL11515	10040	1	None	2	2	Guinea pig	6.5	pEC50	=	6.5	Functional	Effective concentration for agonist activity in guinea pig ileum whole segmentEffective concentration for agonist activity in guinea pig ileum whole segment	ChEMBL	333	9	2	2	4.3	CCNCCc1c[nH]c(CCC(c2ccccc2)c2ccccc2)n1	10.1021/jm991056a
	10447834	1933	4	None	2	3	Guinea pig	6.5	pEC50	=	6.5	Functional	Effective concentration for agonism activity in Endothelium-Denuded guinea pig aortic segmentEffective concentration for agonism activity in Endothelium-Denuded guinea pig aortic segment	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	4026	1933	4	None	2	3	Guinea pig	6.5	pEC50	=	6.5	Functional	Effective concentration for agonism activity in Endothelium-Denuded guinea pig aortic segmentEffective concentration for agonism activity in Endothelium-Denuded guinea pig aortic segment	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	CHEMBL275507	1933	4	None	2	3	Guinea pig	6.5	pEC50	=	6.5	Functional	Effective concentration for agonism activity in Endothelium-Denuded guinea pig aortic segmentEffective concentration for agonism activity in Endothelium-Denuded guinea pig aortic segment	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	11791817	98303	0	None	1	2	Rat	6.5	pEC50	=	6.5	Functional	Effective concentration for agonism activity in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619Effective concentration for agonism activity in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619	ChEMBL	345	9	2	2	4.5	c1ccc(C(CCc2nc(CCNC3CC3)c[nH]2)c2ccccc2)cc1	10.1021/jm991056a
	CHEMBL274831	98303	0	None	1	2	Rat	6.5	pEC50	=	6.5	Functional	Effective concentration for agonism activity in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619Effective concentration for agonism activity in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619	ChEMBL	345	9	2	2	4.5	c1ccc(C(CCc2nc(CCNC3CC3)c[nH]2)c2ccccc2)cc1	10.1021/jm991056a
	10685002	10160	0	None	-	1	Guinea pig	4.4	pEC50	=	4.4	Functional	Effective concentration for agonist activity in guinea pig ileum whole segmentEffective concentration for agonist activity in guinea pig ileum whole segment	ChEMBL	291	6	2	2	3.3	NCCc1c[nH]c(CC(c2ccccc2)c2ccccc2)n1	10.1021/jm991056a
	CHEMBL11584	10160	0	None	-	1	Guinea pig	4.4	pEC50	=	4.4	Functional	Effective concentration for agonist activity in guinea pig ileum whole segmentEffective concentration for agonist activity in guinea pig ileum whole segment	ChEMBL	291	6	2	2	3.3	NCCc1c[nH]c(CC(c2ccccc2)c2ccccc2)n1	10.1021/jm991056a
	1204	1932	119	None	-4	10	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human H1 receptor expressed in 293-EBNA cells by luciferase reporter gene assayAgonist activity at human H1 receptor expressed in 293-EBNA cells by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0603318
	1247	1932	119	None	-4	10	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human H1 receptor expressed in 293-EBNA cells by luciferase reporter gene assayAgonist activity at human H1 receptor expressed in 293-EBNA cells by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0603318
	1375	1932	119	None	-4	10	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human H1 receptor expressed in 293-EBNA cells by luciferase reporter gene assayAgonist activity at human H1 receptor expressed in 293-EBNA cells by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0603318
	774	1932	119	None	-4	10	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human H1 receptor expressed in 293-EBNA cells by luciferase reporter gene assayAgonist activity at human H1 receptor expressed in 293-EBNA cells by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0603318
	CHEMBL90	1932	119	None	-4	10	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human H1 receptor expressed in 293-EBNA cells by luciferase reporter gene assayAgonist activity at human H1 receptor expressed in 293-EBNA cells by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0603318
	DB05381	1932	119	None	-4	10	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human H1 receptor expressed in 293-EBNA cells by luciferase reporter gene assayAgonist activity at human H1 receptor expressed in 293-EBNA cells by luciferase reporter gene assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0603318
	10403687	2511	3	None	1	2	Guinea pig	6.3	pEC50	=	6.3	Functional	Effective concentration for agonism activity in endothelium-denuded guinea pig aortic segmentEffective concentration for agonism activity in endothelium-denuded guinea pig aortic segment	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	1205	2511	3	None	1	2	Guinea pig	6.3	pEC50	=	6.3	Functional	Effective concentration for agonism activity in endothelium-denuded guinea pig aortic segmentEffective concentration for agonism activity in endothelium-denuded guinea pig aortic segment	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	CHEMBL275035	2511	3	None	1	2	Guinea pig	6.3	pEC50	=	6.3	Functional	Effective concentration for agonism activity in endothelium-denuded guinea pig aortic segmentEffective concentration for agonism activity in endothelium-denuded guinea pig aortic segment	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	10403687	2511	3	None	1	2	Guinea pig	7.2	pEC50	=	7.2	Functional	Effective concentration for agonist activity in guinea pig ileum whole segmentEffective concentration for agonist activity in guinea pig ileum whole segment	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	1205	2511	3	None	1	2	Guinea pig	7.2	pEC50	=	7.2	Functional	Effective concentration for agonist activity in guinea pig ileum whole segmentEffective concentration for agonist activity in guinea pig ileum whole segment	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	CHEMBL275035	2511	3	None	1	2	Guinea pig	7.2	pEC50	=	7.2	Functional	Effective concentration for agonist activity in guinea pig ileum whole segmentEffective concentration for agonist activity in guinea pig ileum whole segment	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	11846300	80266	3	None	2	2	Human	8.2	pEC50	=	8.2	Functional	Activity at human histamine H1 receptor transfected in COS7 cells by NF-kappaB luciferase reporter assayActivity at human histamine H1 receptor transfected in COS7 cells by NF-kappaB luciferase reporter assay	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1021/jm051008s
	CHEMBL213912	80266	3	None	2	2	Human	8.2	pEC50	=	8.2	Functional	Activity at human histamine H1 receptor transfected in COS7 cells by NF-kappaB luciferase reporter assayActivity at human histamine H1 receptor transfected in COS7 cells by NF-kappaB luciferase reporter assay	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1021/jm051008s
	10688111	10040	1	None	-2	2	Rat	6.2	pEC50	=	6.2	Functional	Effective concentration for agonism activity in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619Effective concentration for agonism activity in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619	ChEMBL	333	9	2	2	4.3	CCNCCc1c[nH]c(CCC(c2ccccc2)c2ccccc2)n1	10.1021/jm991056a
	CHEMBL11515	10040	1	None	-2	2	Rat	6.2	pEC50	=	6.2	Functional	Effective concentration for agonism activity in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619Effective concentration for agonism activity in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619	ChEMBL	333	9	2	2	4.3	CCNCCc1c[nH]c(CCC(c2ccccc2)c2ccccc2)n1	10.1021/jm991056a
	10403687	2511	3	None	1	2	Guinea pig	7.1	pEC50	=	7.1	Functional	Effective concentration for agonism activity in Endothelium-Denuded guinea pig aortic segmentEffective concentration for agonism activity in Endothelium-Denuded guinea pig aortic segment	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	1205	2511	3	None	1	2	Guinea pig	7.1	pEC50	=	7.1	Functional	Effective concentration for agonism activity in Endothelium-Denuded guinea pig aortic segmentEffective concentration for agonism activity in Endothelium-Denuded guinea pig aortic segment	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	CHEMBL275035	2511	3	None	1	2	Guinea pig	7.1	pEC50	=	7.1	Functional	Effective concentration for agonism activity in Endothelium-Denuded guinea pig aortic segmentEffective concentration for agonism activity in Endothelium-Denuded guinea pig aortic segment	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	91613	17987	34	None	5	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay	ChEMBL	125	2	2	2	0.2	Cc1ncc(CCN)[nH]1	10.1016/j.bmcl.2010.10.041
	CHEMBL12620	17987	34	None	5	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayAgonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay	ChEMBL	125	2	2	2	0.2	Cc1ncc(CCN)[nH]1	10.1016/j.bmcl.2010.10.041
	10042467	1426	1	None	-1	2	Guinea pig	7.1	pEC50	=	7.1	Functional	Effective concentration for agonist activity in guinea pig ileum whole segmentEffective concentration for agonist activity in guinea pig ileum whole segment	ChEMBL	333	8	1	2	4.3	CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C	10.1021/jm991056a
	1203	1426	1	None	-1	2	Guinea pig	7.1	pEC50	=	7.1	Functional	Effective concentration for agonist activity in guinea pig ileum whole segmentEffective concentration for agonist activity in guinea pig ileum whole segment	ChEMBL	333	8	1	2	4.3	CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C	10.1021/jm991056a
	CHEMBL11553	1426	1	None	-1	2	Guinea pig	7.1	pEC50	=	7.1	Functional	Effective concentration for agonist activity in guinea pig ileum whole segmentEffective concentration for agonist activity in guinea pig ileum whole segment	ChEMBL	333	8	1	2	4.3	CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C	10.1021/jm991056a
	10042467	1426	1	None	-1	2	Guinea pig	6.1	pEC50	=	6.1	Functional	Effective concentration for agonism activity in endothelium-denuded guinea pig aortic segmentEffective concentration for agonism activity in endothelium-denuded guinea pig aortic segment	ChEMBL	333	8	1	2	4.3	CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C	10.1021/jm991056a
	1203	1426	1	None	-1	2	Guinea pig	6.1	pEC50	=	6.1	Functional	Effective concentration for agonism activity in endothelium-denuded guinea pig aortic segmentEffective concentration for agonism activity in endothelium-denuded guinea pig aortic segment	ChEMBL	333	8	1	2	4.3	CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C	10.1021/jm991056a
	CHEMBL11553	1426	1	None	-1	2	Guinea pig	6.1	pEC50	=	6.1	Functional	Effective concentration for agonism activity in endothelium-denuded guinea pig aortic segmentEffective concentration for agonism activity in endothelium-denuded guinea pig aortic segment	ChEMBL	333	8	1	2	4.3	CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C	10.1021/jm991056a
	10447834	1933	4	None	-2	3	Rat	6.1	pEC50	=	6.1	Functional	Effective concentration for agonism activity in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619Effective concentration for agonism activity in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	4026	1933	4	None	-2	3	Rat	6.1	pEC50	=	6.1	Functional	Effective concentration for agonism activity in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619Effective concentration for agonism activity in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	CHEMBL275507	1933	4	None	-2	3	Rat	6.1	pEC50	=	6.1	Functional	Effective concentration for agonism activity in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619Effective concentration for agonism activity in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	11976	920	59	None	-9	16	Human	9.0	pIC50	=	9	Functional	Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assayAntagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assay	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1021/jm300671m
	667467	920	59	None	-9	16	Human	9.0	pIC50	=	9	Functional	Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assayAntagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assay	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1021/jm300671m
	CHEMBL908	920	59	None	-9	16	Human	9.0	pIC50	=	9	Functional	Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assayAntagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assay	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1021/jm300671m
	DB01239	920	59	None	-9	16	Human	9.0	pIC50	=	9	Functional	Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assayAntagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assay	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1021/jm300671m
	13623342	64347	0	None	-	1	Guinea pig	8.0	pIC50	=	8	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	286	5	0	5	1.9	C=COCCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	CHEMBL18123	64347	0	None	-	1	Guinea pig	8.0	pIC50	=	8	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	286	5	0	5	1.9	C=COCCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	3071006	65015	1	None	-	1	Guinea pig	8.0	pIC50	=	8	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	314	6	0	5	2.4	C=CCOCCn1c(N2CCCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	CHEMBL18233	65015	1	None	-	1	Guinea pig	8.0	pIC50	=	8	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	314	6	0	5	2.4	C=CCOCCn1c(N2CCCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	13623366	66714	0	None	-	1	Guinea pig	8.0	pIC50	=	8	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	330	7	0	5	3.0	CCCCOCCn1c(N2CCCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	CHEMBL18561	66714	0	None	-	1	Guinea pig	8.0	pIC50	=	8	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	330	7	0	5	3.0	CCCCOCCn1c(N2CCCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	3071004	167760	5	None	-	1	Guinea pig	8.0	pIC50	=	8	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	288	5	0	5	1.8	CCOCCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	CHEMBL430338	167760	5	None	-	1	Guinea pig	8.0	pIC50	=	8	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	288	5	0	5	1.8	CCOCCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	1227	2489	43	None	2	14	Human	8.0	pIC50	=	8	Functional	Inverse agonist activity at human wild-type histamine H1 receptor assessed as NF-kappaB activation after 48 hrs by luciferase reporter gene assayInverse agonist activity at human wild-type histamine H1 receptor assessed as NF-kappaB activation after 48 hrs by luciferase reporter gene assay	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/nchembio714
	2331	2489	43	None	2	14	Human	8.0	pIC50	=	8	Functional	Inverse agonist activity at human wild-type histamine H1 receptor assessed as NF-kappaB activation after 48 hrs by luciferase reporter gene assayInverse agonist activity at human wild-type histamine H1 receptor assessed as NF-kappaB activation after 48 hrs by luciferase reporter gene assay	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/nchembio714
	3957	2489	43	None	2	14	Human	8.0	pIC50	=	8	Functional	Inverse agonist activity at human wild-type histamine H1 receptor assessed as NF-kappaB activation after 48 hrs by luciferase reporter gene assayInverse agonist activity at human wild-type histamine H1 receptor assessed as NF-kappaB activation after 48 hrs by luciferase reporter gene assay	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/nchembio714
	4992	2489	43	None	2	14	Human	8.0	pIC50	=	8	Functional	Inverse agonist activity at human wild-type histamine H1 receptor assessed as NF-kappaB activation after 48 hrs by luciferase reporter gene assayInverse agonist activity at human wild-type histamine H1 receptor assessed as NF-kappaB activation after 48 hrs by luciferase reporter gene assay	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/nchembio714
	CHEMBL511	2489	43	None	2	14	Human	8.0	pIC50	=	8	Functional	Inverse agonist activity at human wild-type histamine H1 receptor assessed as NF-kappaB activation after 48 hrs by luciferase reporter gene assayInverse agonist activity at human wild-type histamine H1 receptor assessed as NF-kappaB activation after 48 hrs by luciferase reporter gene assay	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/nchembio714
	DB06691	2489	43	None	2	14	Human	8.0	pIC50	=	8	Functional	Inverse agonist activity at human wild-type histamine H1 receptor assessed as NF-kappaB activation after 48 hrs by luciferase reporter gene assayInverse agonist activity at human wild-type histamine H1 receptor assessed as NF-kappaB activation after 48 hrs by luciferase reporter gene assay	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/nchembio714
	44458944	99060	0	None	-	1	Guinea pig	8.0	pIC50	=	8.0	Functional	In vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileumIn vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileum	ChEMBL	337	3	0	1	5.5	c1ccc(CN2CCC3C(=C(c4ccccc4)c4ccccc43)C2)cc1	10.1016/s0960-894x(00)00199-2
	CHEMBL280432	99060	0	None	-	1	Guinea pig	8.0	pIC50	=	8.0	Functional	In vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileumIn vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileum	ChEMBL	337	3	0	1	5.5	c1ccc(CN2CCC3C(=C(c4ccccc4)c4ccccc43)C2)cc1	10.1016/s0960-894x(00)00199-2
	44224259	62723	5	None	30	2	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	291	3	0	3	3.3	CN1CCc2c(c3ccccc3n2CCc2cccnc2)C1	10.1016/j.bmcl.2009.04.128
	CHEMBL1783959	62723	5	None	30	2	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	291	3	0	3	3.3	CN1CCc2c(c3ccccc3n2CCc2cccnc2)C1	10.1016/j.bmcl.2009.04.128
	3529324	208354	1	None	-	1	Guinea pig	6.0	pIC50	=	6	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	306	6	0	3	3.3	CC(C)c1ccc(C2SCC(=O)N2CCCN(C)C)cc1	10.1021/jm00093a025
	CHEMBL1202934	208354	1	None	-	1	Guinea pig	6.0	pIC50	=	6	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	306	6	0	3	3.3	CC(C)c1ccc(C2SCC(=O)N2CCCN(C)C)cc1	10.1021/jm00093a025
	CHEMBL99417	208354	1	None	-	1	Guinea pig	6.0	pIC50	=	6	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	306	6	0	3	3.3	CC(C)c1ccc(C2SCC(=O)N2CCCN(C)C)cc1	10.1021/jm00093a025
	44126329	62718	6	None	-2	2	Human	5.0	pIC50	=	5	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assay	ChEMBL	305	3	0	3	3.6	Cc1ccc2c(c1)c1c(n2CCc2ccccn2)CCN(C)C1	10.1016/j.bmcl.2009.04.128
	CHEMBL1783954	62718	6	None	-2	2	Human	5.0	pIC50	=	5	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assay	ChEMBL	305	3	0	3	3.6	Cc1ccc2c(c1)c1c(n2CCc2ccccn2)CCN(C)C1	10.1016/j.bmcl.2009.04.128
	153996	112668	2	None	-57	6	Human	5.0	pIC50	=	5	Functional	Compound was evaluated for the antagonistic activity against H1 receptorCompound was evaluated for the antagonistic activity against H1 receptor	ChEMBL	639	10	1	6	5.7	COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	CHEMBL330366	112668	2	None	-57	6	Human	5.0	pIC50	=	5	Functional	Compound was evaluated for the antagonistic activity against H1 receptorCompound was evaluated for the antagonistic activity against H1 receptor	ChEMBL	639	10	1	6	5.7	COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	CHEMBL539021	112668	2	None	-57	6	Human	5.0	pIC50	=	5	Functional	Compound was evaluated for the antagonistic activity against H1 receptorCompound was evaluated for the antagonistic activity against H1 receptor	ChEMBL	639	10	1	6	5.7	COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	44126270	199151	6	None	10	2	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challenge	ChEMBL	320	4	0	3	3.9	COc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
	CHEMBL589389	199151	6	None	10	2	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challenge	ChEMBL	320	4	0	3	3.9	COc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
	3071008	98749	2	None	-	1	Guinea pig	8.0	pIC50	=	8.0	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	274	5	1	5	1.5	CCOCCn1c(N2CCNCC2)nc2ccccc21	10.1021/jm00157a010
	CHEMBL278053	98749	2	None	-	1	Guinea pig	8.0	pIC50	=	8.0	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	274	5	1	5	1.5	CCOCCn1c(N2CCNCC2)nc2ccccc21	10.1021/jm00157a010
	54585846	62727	5	None	38	2	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	323	3	0	3	3.7	Cc1ccc(CCn2c3c(c4cc(F)ccc42)CN(C)CC3)cn1	10.1016/j.bmcl.2009.04.128
	CHEMBL1783963	62727	5	None	38	2	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	323	3	0	3	3.7	Cc1ccc(CCn2c3c(c4cc(F)ccc42)CN(C)CC3)cn1	10.1016/j.bmcl.2009.04.128
	44126269	201484	5	None	2	2	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challenge	ChEMBL	318	3	0	2	4.5	Cc1ccc(CCn2c3c(c4cc(C)ccc42)CN(C)CC3)cc1	10.1016/j.bmcl.2009.11.037
	CHEMBL605081	201484	5	None	2	2	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challenge	ChEMBL	318	3	0	2	4.5	Cc1ccc(CCn2c3c(c4cc(C)ccc42)CN(C)CC3)cc1	10.1016/j.bmcl.2009.11.037
	1210	918	51	None	2	22	Guinea pig	7.9	pIC50	=	7.9	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00157a010
	1213	918	51	None	2	22	Guinea pig	7.9	pIC50	=	7.9	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00157a010
	2725	918	51	None	2	22	Guinea pig	7.9	pIC50	=	7.9	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00157a010
	33036	918	51	None	2	22	Guinea pig	7.9	pIC50	=	7.9	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00157a010
	4411	918	51	None	2	22	Guinea pig	7.9	pIC50	=	7.9	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00157a010
	616	918	51	None	2	22	Guinea pig	7.9	pIC50	=	7.9	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00157a010
	6976	918	51	None	2	22	Guinea pig	7.9	pIC50	=	7.9	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00157a010
	716121	918	51	None	2	22	Guinea pig	7.9	pIC50	=	7.9	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00157a010
	CHEMBL1201353	918	51	None	2	22	Guinea pig	7.9	pIC50	=	7.9	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00157a010
	CHEMBL1554789	918	51	None	2	22	Guinea pig	7.9	pIC50	=	7.9	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00157a010
	CHEMBL505	918	51	None	2	22	Guinea pig	7.9	pIC50	=	7.9	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00157a010
	DB01114	918	51	None	2	22	Guinea pig	7.9	pIC50	=	7.9	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00157a010
	DB13679	918	51	None	2	22	Guinea pig	7.9	pIC50	=	7.9	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00157a010
	3071000	98656	1	None	-	1	Guinea pig	7.9	pIC50	=	7.9	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	298	5	0	5	1.4	C#CCOCCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	CHEMBL277311	98656	1	None	-	1	Guinea pig	7.9	pIC50	=	7.9	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	298	5	0	5	1.4	C#CCOCCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	54582939	62721	6	None	8	2	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	369	3	0	3	4.0	CN1CCc2c(c3cc(Br)ccc3n2CCc2ccccn2)C1	10.1016/j.bmcl.2009.04.128
	CHEMBL1783957	62721	6	None	8	2	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	369	3	0	3	4.0	CN1CCc2c(c3cc(Br)ccc3n2CCc2ccccn2)C1	10.1016/j.bmcl.2009.04.128
	54579957	62728	5	None	36	2	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	291	3	0	3	3.3	CN1CCc2c(c3ccccc3n2CCc2ccncc2)C1	10.1016/j.bmcl.2009.04.128
	CHEMBL1783964	62728	5	None	36	2	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	291	3	0	3	3.3	CN1CCc2c(c3ccccc3n2CCc2ccncc2)C1	10.1016/j.bmcl.2009.04.128
	54580942	62731	9	None	13	2	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	309	3	0	3	3.4	CN1CCc2c(c3cc(F)ccc3n2CCc2ccncc2)C1	10.1016/j.bmcl.2009.04.128
	CHEMBL1783967	62731	9	None	13	2	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	309	3	0	3	3.4	CN1CCc2c(c3cc(F)ccc3n2CCc2ccncc2)C1	10.1016/j.bmcl.2009.04.128
	4440380	4255	3	None	-	1	Guinea pig	5.9	pIC50	=	5.9	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	278	5	0	3	2.5	Cc1ccc(C2SCC(=O)N2CCCN(C)C)cc1	10.1021/jm00093a025
	CHEMBL100487	4255	3	None	-	1	Guinea pig	5.9	pIC50	=	5.9	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	278	5	0	3	2.5	Cc1ccc(C2SCC(=O)N2CCCN(C)C)cc1	10.1021/jm00093a025
	CHEMBL1202938	4255	3	None	-	1	Guinea pig	5.9	pIC50	=	5.9	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	278	5	0	3	2.5	Cc1ccc(C2SCC(=O)N2CCCN(C)C)cc1	10.1021/jm00093a025
	10234086	111634	0	None	-6	2	Human	5.9	pIC50	=	5.9	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	744	13	0	10	6.7	COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccccc5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1	10.1016/S0960-894X(97)10097-X
	CHEMBL328511	111634	0	None	-6	2	Human	5.9	pIC50	=	5.9	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	744	13	0	10	6.7	COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccccc5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1	10.1016/S0960-894X(97)10097-X
	10190770	208015	0	None	-1	2	Human	6.9	pIC50	=	6.9	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	772	12	0	8	8.3	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	CHEMBL330430	208015	0	None	-1	2	Human	6.9	pIC50	=	6.9	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	772	12	0	8	8.3	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	CHEMBL97357	208015	0	None	-1	2	Human	6.9	pIC50	=	6.9	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	772	12	0	8	8.3	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	54585848	62734	6	None	5	2	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	316	3	0	4	3.1	CN1CCc2c(c3cc(C#N)ccc3n2CCc2ccccn2)C1	10.1016/j.bmcl.2009.04.128
	CHEMBL1783971	62734	6	None	5	2	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	316	3	0	4	3.1	CN1CCc2c(c3cc(C#N)ccc3n2CCc2ccccn2)C1	10.1016/j.bmcl.2009.04.128
	13623354	98980	0	None	-	1	Guinea pig	7.9	pIC50	=	7.9	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	274	4	0	5	1.4	COCCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	CHEMBL279872	98980	0	None	-	1	Guinea pig	7.9	pIC50	=	7.9	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	274	4	0	5	1.4	COCCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	46225000	199115	5	None	9	2	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as reduction of histamine-induced intracellular calcium spike at phase 2 treated 20 to 30 seconds after histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as reduction of histamine-induced intracellular calcium spike at phase 2 treated 20 to 30 seconds after histamine challenge	ChEMBL	308	3	0	2	4.0	CN1CCc2c(c3cc(F)ccc3n2CCc2ccccc2)C1	10.1016/j.bmcl.2009.11.037
	CHEMBL589148	199115	5	None	9	2	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as reduction of histamine-induced intracellular calcium spike at phase 2 treated 20 to 30 seconds after histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as reduction of histamine-induced intracellular calcium spike at phase 2 treated 20 to 30 seconds after histamine challenge	ChEMBL	308	3	0	2	4.0	CN1CCc2c(c3cc(F)ccc3n2CCc2ccccc2)C1	10.1016/j.bmcl.2009.11.037
	13623347	61054	0	None	-	1	Guinea pig	5.9	pIC50	=	5.9	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	286	4	0	4	3.1	CCCC(C)n1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	CHEMBL17635	61054	0	None	-	1	Guinea pig	5.9	pIC50	=	5.9	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	286	4	0	4	3.1	CCCC(C)n1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	13623346	98945	0	None	-	1	Guinea pig	5.9	pIC50	=	5.9	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	286	4	0	4	2.8	CC(C)CCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	CHEMBL279621	98945	0	None	-	1	Guinea pig	5.9	pIC50	=	5.9	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	286	4	0	4	2.8	CC(C)CCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	42631003	199618	13	None	2	2	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as reduction of histamine-induced intracellular calcium spike at phase 2 treated 20 to 30 seconds after histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as reduction of histamine-induced intracellular calcium spike at phase 2 treated 20 to 30 seconds after histamine challenge	ChEMBL	304	3	0	2	4.2	Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
	CHEMBL592752	199618	13	None	2	2	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as reduction of histamine-induced intracellular calcium spike at phase 2 treated 20 to 30 seconds after histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as reduction of histamine-induced intracellular calcium spike at phase 2 treated 20 to 30 seconds after histamine challenge	ChEMBL	304	3	0	2	4.2	Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
	13623371	65205	0	None	-	1	Guinea pig	7.8	pIC50	=	7.8	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	378	7	0	5	3.8	CCOCCn1c(N2CCCN(Cc3ccccc3)CC2)nc2ccccc21	10.1021/jm00157a010
	CHEMBL18255	65205	0	None	-	1	Guinea pig	7.8	pIC50	=	7.8	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	378	7	0	5	3.8	CCOCCn1c(N2CCCN(Cc3ccccc3)CC2)nc2ccccc21	10.1021/jm00157a010
	13623360	98808	0	None	-	1	Guinea pig	7.8	pIC50	=	7.8	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	330	8	0	5	3.0	CCCCN1CCN(c2nc3ccccc3n2CCOCC)CC1	10.1021/jm00157a010
	CHEMBL278504	98808	0	None	-	1	Guinea pig	7.8	pIC50	=	7.8	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	330	8	0	5	3.0	CCCCN1CCN(c2nc3ccccc3n2CCOCC)CC1	10.1021/jm00157a010
	13623338	63348	0	None	-	1	Guinea pig	6.8	pIC50	=	6.8	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	314	7	0	4	3.8	CCCCCCCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	CHEMBL17946	63348	0	None	-	1	Guinea pig	6.8	pIC50	=	6.8	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	314	7	0	4	3.8	CCCCCCCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	46224879	201547	3	None	-1	2	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as reduction of histamine-induced intracellular calcium spike at phase 2 treated 20 to 30 seconds after histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as reduction of histamine-induced intracellular calcium spike at phase 2 treated 20 to 30 seconds after histamine challenge	ChEMBL	302	2	0	2	4.6	Cc1ccc2c(c1)c1c(n2/C=C\c2ccccc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
	CHEMBL605405	201547	3	None	-1	2	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as reduction of histamine-induced intracellular calcium spike at phase 2 treated 20 to 30 seconds after histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as reduction of histamine-induced intracellular calcium spike at phase 2 treated 20 to 30 seconds after histamine challenge	ChEMBL	302	2	0	2	4.6	Cc1ccc2c(c1)c1c(n2/C=C\c2ccccc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
	9832306	112724	0	None	2	2	Human	6.8	pIC50	=	6.8	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	806	17	0	10	8.2	CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC	10.1016/S0960-894X(97)10097-X
	CHEMBL330367	112724	0	None	2	2	Human	6.8	pIC50	=	6.8	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	806	17	0	10	8.2	CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC	10.1016/S0960-894X(97)10097-X
	CHEMBL330462	112724	0	None	2	2	Human	6.8	pIC50	=	6.8	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	806	17	0	10	8.2	CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC	10.1016/S0960-894X(97)10097-X
	197033	199152	64	None	1	2	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challenge	ChEMBL	319	3	0	3	3.9	Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
	CHEMBL589390	199152	64	None	1	2	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challenge	ChEMBL	319	3	0	3	3.9	Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
	1227	2489	43	None	2	14	Human	6.8	pIC50	=	6.8	Functional	Inverse agonist activity at human wild-type histamine H1 receptor N7.45L mutant assessed as NF-kappaB activation after 48 hrs by luciferase reporter gene assayInverse agonist activity at human wild-type histamine H1 receptor N7.45L mutant assessed as NF-kappaB activation after 48 hrs by luciferase reporter gene assay	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/nchembio714
	2331	2489	43	None	2	14	Human	6.8	pIC50	=	6.8	Functional	Inverse agonist activity at human wild-type histamine H1 receptor N7.45L mutant assessed as NF-kappaB activation after 48 hrs by luciferase reporter gene assayInverse agonist activity at human wild-type histamine H1 receptor N7.45L mutant assessed as NF-kappaB activation after 48 hrs by luciferase reporter gene assay	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/nchembio714
	3957	2489	43	None	2	14	Human	6.8	pIC50	=	6.8	Functional	Inverse agonist activity at human wild-type histamine H1 receptor N7.45L mutant assessed as NF-kappaB activation after 48 hrs by luciferase reporter gene assayInverse agonist activity at human wild-type histamine H1 receptor N7.45L mutant assessed as NF-kappaB activation after 48 hrs by luciferase reporter gene assay	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/nchembio714
	4992	2489	43	None	2	14	Human	6.8	pIC50	=	6.8	Functional	Inverse agonist activity at human wild-type histamine H1 receptor N7.45L mutant assessed as NF-kappaB activation after 48 hrs by luciferase reporter gene assayInverse agonist activity at human wild-type histamine H1 receptor N7.45L mutant assessed as NF-kappaB activation after 48 hrs by luciferase reporter gene assay	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/nchembio714
	CHEMBL511	2489	43	None	2	14	Human	6.8	pIC50	=	6.8	Functional	Inverse agonist activity at human wild-type histamine H1 receptor N7.45L mutant assessed as NF-kappaB activation after 48 hrs by luciferase reporter gene assayInverse agonist activity at human wild-type histamine H1 receptor N7.45L mutant assessed as NF-kappaB activation after 48 hrs by luciferase reporter gene assay	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/nchembio714
	DB06691	2489	43	None	2	14	Human	6.8	pIC50	=	6.8	Functional	Inverse agonist activity at human wild-type histamine H1 receptor N7.45L mutant assessed as NF-kappaB activation after 48 hrs by luciferase reporter gene assayInverse agonist activity at human wild-type histamine H1 receptor N7.45L mutant assessed as NF-kappaB activation after 48 hrs by luciferase reporter gene assay	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/nchembio714
	197033	199152	64	None	1	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as reduction of histamine-induced intracellular calcium spike at phase 2 treated 20 to 30 seconds after histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as reduction of histamine-induced intracellular calcium spike at phase 2 treated 20 to 30 seconds after histamine challenge	ChEMBL	319	3	0	3	3.9	Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
	CHEMBL589390	199152	64	None	1	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as reduction of histamine-induced intracellular calcium spike at phase 2 treated 20 to 30 seconds after histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as reduction of histamine-induced intracellular calcium spike at phase 2 treated 20 to 30 seconds after histamine challenge	ChEMBL	319	3	0	3	3.9	Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
	197033	199152	64	None	1	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assay	ChEMBL	319	3	0	3	3.9	Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1	10.1016/j.bmcl.2009.04.128
	CHEMBL589390	199152	64	None	1	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assay	ChEMBL	319	3	0	3	3.9	Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1	10.1016/j.bmcl.2009.04.128
	54582940	62722	5	None	1	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assay	ChEMBL	359	3	0	3	4.3	CN1CCc2c(c3cc(C(F)(F)F)ccc3n2CCc2ccccn2)C1	10.1016/j.bmcl.2009.04.128
	CHEMBL1783958	62722	5	None	1	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assay	ChEMBL	359	3	0	3	4.3	CN1CCc2c(c3cc(C(F)(F)F)ccc3n2CCc2ccccn2)C1	10.1016/j.bmcl.2009.04.128
	13623367	60379	0	None	-	1	Guinea pig	7.8	pIC50	=	7.8	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	316	6	0	5	2.6	CCOCCn1c(N2CCCN(CC)CC2)nc2ccccc21	10.1021/jm00157a010
	CHEMBL17474	60379	0	None	-	1	Guinea pig	7.8	pIC50	=	7.8	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	316	6	0	5	2.6	CCOCCn1c(N2CCCN(CC)CC2)nc2ccccc21	10.1021/jm00157a010
	13623359	64562	1	None	-	1	Guinea pig	7.8	pIC50	=	7.8	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	316	7	0	5	2.6	CCCN1CCN(c2nc3ccccc3n2CCOCC)CC1	10.1021/jm00157a010
	CHEMBL18151	64562	1	None	-	1	Guinea pig	7.8	pIC50	=	7.8	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	316	7	0	5	2.6	CCCN1CCN(c2nc3ccccc3n2CCOCC)CC1	10.1021/jm00157a010
	3071032	65039	1	None	-	1	Guinea pig	7.8	pIC50	=	7.8	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	316	6	0	5	2.6	CCCOCCn1c(N2CCCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	CHEMBL18234	65039	1	None	-	1	Guinea pig	7.8	pIC50	=	7.8	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	316	6	0	5	2.6	CCCOCCn1c(N2CCCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	621659	62729	10	None	-2	2	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	305	3	0	3	3.6	Cc1ccc2c(c1)c1c(n2CCc2ccncc2)CCN(C)C1	10.1016/j.bmcl.2009.04.128
	CHEMBL1783965	62729	10	None	-2	2	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	305	3	0	3	3.6	Cc1ccc2c(c1)c1c(n2CCc2ccncc2)CCN(C)C1	10.1016/j.bmcl.2009.04.128
	197033	199152	64	None	1	2	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	319	3	0	3	3.9	Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1	10.1016/j.bmcl.2009.04.128
	CHEMBL589390	199152	64	None	1	2	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	319	3	0	3	3.9	Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1	10.1016/j.bmcl.2009.04.128
	44458903	90646	0	None	-	1	Guinea pig	7.8	pIC50	=	7.8	Functional	In vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileumIn vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileum	ChEMBL	275	2	0	1	4.3	CCN1CCC2=C(C1)C(c1ccccc1)c1ccccc12	10.1016/s0960-894x(00)00199-2
	CHEMBL23897	90646	0	None	-	1	Guinea pig	7.8	pIC50	=	7.8	Functional	In vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileumIn vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileum	ChEMBL	275	2	0	1	4.3	CCN1CCC2=C(C1)C(c1ccccc1)c1ccccc12	10.1016/s0960-894x(00)00199-2
	2773189	59739	3	None	-	1	Guinea pig	7.8	pIC50	=	7.8	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	306	3	0	4	2.8	CN1CCN(c2nc3ccccc3n2Cc2ccccc2)CC1	10.1021/jm00157a010
	CHEMBL17246	59739	3	None	-	1	Guinea pig	7.8	pIC50	=	7.8	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	306	3	0	4	2.8	CN1CCN(c2nc3ccccc3n2Cc2ccccc2)CC1	10.1021/jm00157a010
	3071002	63017	1	None	-	1	Guinea pig	7.8	pIC50	=	7.8	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	300	6	0	5	2.0	C=CCOCCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	CHEMBL17876	63017	1	None	-	1	Guinea pig	7.8	pIC50	=	7.8	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	300	6	0	5	2.0	C=CCOCCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	145990794	166800	0	None	-28	6	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	437	6	0	5	3.8	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	CHEMBL4284346	166800	0	None	-28	6	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	437	6	0	5	3.8	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	4919	206234	23	None	-263	5	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assayAntagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assay	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1021/jm300671m
	CHEMBL86715	206234	23	None	-263	5	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assayAntagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assay	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1021/jm300671m
	13623352	60006	0	None	-	1	Guinea pig	7.8	pIC50	=	7.8	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	288	5	0	5	2.2	CCCOCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	CHEMBL17349	60006	0	None	-	1	Guinea pig	7.8	pIC50	=	7.8	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	288	5	0	5	2.2	CCCOCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	3071010	63919	1	None	-	1	Guinea pig	7.8	pIC50	=	7.8	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	302	6	0	5	2.2	CCOCCn1c(N2CCN(CC)CC2)nc2ccccc21	10.1021/jm00157a010
	CHEMBL18060	63919	1	None	-	1	Guinea pig	7.8	pIC50	=	7.8	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	302	6	0	5	2.2	CCOCCn1c(N2CCN(CC)CC2)nc2ccccc21	10.1021/jm00157a010
	46224877	200701	5	None	74	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as reduction of histamine-induced intracellular calcium spike at phase 2 treated 20 to 30 seconds after histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as reduction of histamine-induced intracellular calcium spike at phase 2 treated 20 to 30 seconds after histamine challenge	ChEMBL	288	2	0	2	4.3	CN1CCc2c(c3ccccc3n2/C=C\c2ccccc2)C1	10.1016/j.bmcl.2009.11.037
	CHEMBL599913	200701	5	None	74	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as reduction of histamine-induced intracellular calcium spike at phase 2 treated 20 to 30 seconds after histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as reduction of histamine-induced intracellular calcium spike at phase 2 treated 20 to 30 seconds after histamine challenge	ChEMBL	288	2	0	2	4.3	CN1CCc2c(c3ccccc3n2/C=C\c2ccccc2)C1	10.1016/j.bmcl.2009.11.037
	54586812	62717	5	None	12	2	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	291	3	0	3	3.3	CN1CCc2c(c3ccccc3n2CCc2ccccn2)C1	10.1016/j.bmcl.2009.04.128
	CHEMBL1783953	62717	5	None	12	2	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	291	3	0	3	3.3	CN1CCc2c(c3ccccc3n2CCc2ccccn2)C1	10.1016/j.bmcl.2009.04.128
	13623336	60496	0	None	-	1	Guinea pig	7.7	pIC50	=	7.7	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	286	5	0	4	3.0	CCCCCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	CHEMBL17555	60496	0	None	-	1	Guinea pig	7.7	pIC50	=	7.7	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	286	5	0	4	3.0	CCCCCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	13623350	63112	0	None	-	1	Guinea pig	7.7	pIC50	=	7.7	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	304	5	0	5	2.5	CCSCCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	CHEMBL17893	63112	0	None	-	1	Guinea pig	7.7	pIC50	=	7.7	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	304	5	0	5	2.5	CCSCCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	145983928	166412	0	None	-53	6	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	435	6	0	5	3.6	O=C1[C@H]2[C@@H]3C=C[C@@H](C3)[C@H]2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	CHEMBL4277101	166412	0	None	-53	6	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	435	6	0	5	3.6	O=C1[C@H]2[C@@H]3C=C[C@@H](C3)[C@H]2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	3071014	98085	1	None	-	1	Guinea pig	7.7	pIC50	=	7.7	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	302	6	0	5	2.2	CCCOCCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	CHEMBL273320	98085	1	None	-	1	Guinea pig	7.7	pIC50	=	7.7	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	302	6	0	5	2.2	CCCOCCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	126624	208290	10	None	-	1	Guinea pig	4.7	pIC50	=	4.7	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	264	5	0	3	2.2	CN(C)CCCN1C(=O)CSC1c1ccccc1	10.1021/jm00093a025
	CHEMBL1202936	208290	10	None	-	1	Guinea pig	4.7	pIC50	=	4.7	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	264	5	0	3	2.2	CN(C)CCCN1C(=O)CSC1c1ccccc1	10.1021/jm00093a025
	CHEMBL98989	208290	10	None	-	1	Guinea pig	4.7	pIC50	=	4.7	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	264	5	0	3	2.2	CN(C)CCCN1C(=O)CSC1c1ccccc1	10.1021/jm00093a025
	10123138	108526	0	None	-1	2	Human	6.7	pIC50	=	6.7	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	748	12	0	10	6.7	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	CHEMBL317524	108526	0	None	-1	2	Human	6.7	pIC50	=	6.7	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	748	12	0	10	6.7	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	CHEMBL320002	108526	0	None	-1	2	Human	6.7	pIC50	=	6.7	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	748	12	0	10	6.7	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	2861271	4254	9	None	-	1	Guinea pig	4.7	pIC50	=	4.7	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	298	5	0	3	2.9	CN(C)CCCN1C(=O)CSC1c1ccc(Cl)cc1	10.1021/jm00093a025
	CHEMBL100486	4254	9	None	-	1	Guinea pig	4.7	pIC50	=	4.7	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	298	5	0	3	2.9	CN(C)CCCN1C(=O)CSC1c1ccc(Cl)cc1	10.1021/jm00093a025
	46224878	199469	0	None	2	2	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as reduction of histamine-induced intracellular calcium spike at phase 2 treated 20 to 30 seconds after histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as reduction of histamine-induced intracellular calcium spike at phase 2 treated 20 to 30 seconds after histamine challenge	ChEMBL	290	2	0	2	4.0	CN1CCC2C(C1)c1ccccc1N2/C=C/c1ccccc1	10.1016/j.bmcl.2009.11.037
	CHEMBL591568	199469	0	None	2	2	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as reduction of histamine-induced intracellular calcium spike at phase 2 treated 20 to 30 seconds after histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as reduction of histamine-induced intracellular calcium spike at phase 2 treated 20 to 30 seconds after histamine challenge	ChEMBL	290	2	0	2	4.0	CN1CCC2C(C1)c1ccccc1N2/C=C/c1ccccc1	10.1016/j.bmcl.2009.11.037
	54585847	62732	6	None	29	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	359	3	0	3	4.3	CN1CCc2c(c3cc(C(F)(F)F)ccc3n2CCc2ccncc2)C1	10.1016/j.bmcl.2009.04.128
	CHEMBL1783968	62732	6	None	29	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	359	3	0	3	4.3	CN1CCc2c(c3cc(C(F)(F)F)ccc3n2CCc2ccncc2)C1	10.1016/j.bmcl.2009.04.128
	198539	99231	3	None	-	1	Guinea pig	6.7	pIC50	=	6.7	Functional	In vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileumIn vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileum	ChEMBL	259	1	0	1	3.8	CN1CC=C2C(=C(c3ccccc3)c3ccccc32)C1	10.1016/s0960-894x(00)00199-2
	CHEMBL281638	99231	3	None	-	1	Guinea pig	6.7	pIC50	=	6.7	Functional	In vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileumIn vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileum	ChEMBL	259	1	0	1	3.8	CN1CC=C2C(=C(c3ccccc3)c3ccccc32)C1	10.1016/s0960-894x(00)00199-2
	2860026	108376	7	None	-	1	Guinea pig	5.7	pIC50	=	5.7	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	298	5	0	3	2.9	CN(C)CCCN1C(=O)CSC1c1cccc(Cl)c1	10.1021/jm00093a025
	CHEMBL319829	108376	7	None	-	1	Guinea pig	5.7	pIC50	=	5.7	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	298	5	0	3	2.9	CN(C)CCCN1C(=O)CSC1c1cccc(Cl)c1	10.1021/jm00093a025
	7430452	99478	2	None	-	1	Guinea pig	7.6	pIC50	=	7.6	Functional	In vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileumIn vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileum	ChEMBL	309	4	1	3	3.1	CCN1CC[C@@](O)(c2ccccc2)[C@H](C(=O)c2ccccc2)C1	10.1016/s0960-894x(00)00199-2
	CHEMBL283169	99478	2	None	-	1	Guinea pig	7.6	pIC50	=	7.6	Functional	In vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileumIn vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileum	ChEMBL	309	4	1	3	3.1	CCN1CC[C@@](O)(c2ccccc2)[C@H](C(=O)c2ccccc2)C1	10.1016/s0960-894x(00)00199-2
	2861590	107260	7	None	-	1	Guinea pig	5.6	pIC50	=	5.6	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	342	5	0	3	3.0	CN(C)CCCN1C(=O)CSC1c1ccc(Br)cc1	10.1021/jm00093a025
	CHEMBL1202937	107260	7	None	-	1	Guinea pig	5.6	pIC50	=	5.6	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	342	5	0	3	3.0	CN(C)CCCN1C(=O)CSC1c1ccc(Br)cc1	10.1021/jm00093a025
	CHEMBL316951	107260	7	None	-	1	Guinea pig	5.6	pIC50	=	5.6	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	342	5	0	3	3.0	CN(C)CCCN1C(=O)CSC1c1ccc(Br)cc1	10.1021/jm00093a025
	10212223	208140	0	None	-2	2	Human	6.6	pIC50	=	6.6	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	704	12	0	8	7.0	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	CHEMBL431458	208140	0	None	-2	2	Human	6.6	pIC50	=	6.6	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	704	12	0	8	7.0	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	CHEMBL98079	208140	0	None	-2	2	Human	6.6	pIC50	=	6.6	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	704	12	0	8	7.0	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	10190056	111438	0	None	1	2	Human	6.6	pIC50	=	6.6	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	674	11	0	7	7.0	COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3ccccc3)C2)cc1OC	10.1016/S0960-894X(97)10097-X
	CHEMBL327497	111438	0	None	1	2	Human	6.6	pIC50	=	6.6	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	674	11	0	7	7.0	COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3ccccc3)C2)cc1OC	10.1016/S0960-894X(97)10097-X
	13623341	62120	0	None	-	1	Guinea pig	6.6	pIC50	=	6.6	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	320	4	0	4	3.0	CN1CCN(c2nc3ccccc3n2CCc2ccccc2)CC1	10.1021/jm00157a010
	CHEMBL17763	62120	0	None	-	1	Guinea pig	6.6	pIC50	=	6.6	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	320	4	0	4	3.0	CN1CCN(c2nc3ccccc3n2CCc2ccccc2)CC1	10.1021/jm00157a010
	2872050	208226	3	None	-	1	Guinea pig	4.6	pIC50	=	4.6	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	282	5	0	3	2.4	CN(C)CCCN1C(=O)CSC1c1ccc(F)cc1	10.1021/jm00093a025
	CHEMBL1202939	208226	3	None	-	1	Guinea pig	4.6	pIC50	=	4.6	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	282	5	0	3	2.4	CN(C)CCCN1C(=O)CSC1c1ccc(F)cc1	10.1021/jm00093a025
	CHEMBL98605	208226	3	None	-	1	Guinea pig	4.6	pIC50	=	4.6	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	282	5	0	3	2.4	CN(C)CCCN1C(=O)CSC1c1ccc(F)cc1	10.1021/jm00093a025
	2284	3182	33	None	-3	34	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assayAntagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assay	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1021/jm300671m
	4926	3182	33	None	-3	34	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assayAntagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assay	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1021/jm300671m
	7281	3182	33	None	-3	34	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assayAntagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assay	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1021/jm300671m
	CHEMBL564	3182	33	None	-3	34	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assayAntagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assay	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1021/jm300671m
	DB00420	3182	33	None	-3	34	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assayAntagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assay	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1021/jm300671m
	9984168	98289	9	None	-	1	Guinea pig	7.6	pIC50	=	7.6	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	288	5	1	5	1.9	CCOCCn1c(N2CCCNCC2)nc2ccccc21	10.1021/jm00157a010
	CHEMBL274747	98289	9	None	-	1	Guinea pig	7.6	pIC50	=	7.6	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	288	5	1	5	1.9	CCOCCn1c(N2CCCNCC2)nc2ccccc21	10.1021/jm00157a010
	14984033	208178	1	None	-	1	Guinea pig	4.6	pIC50	=	4.6	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	294	6	0	4	2.2	COc1cccc(C2SCC(=O)N2CCCN(C)C)c1	10.1021/jm00093a025
	CHEMBL1202941	208178	1	None	-	1	Guinea pig	4.6	pIC50	=	4.6	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	294	6	0	4	2.2	COc1cccc(C2SCC(=O)N2CCCN(C)C)c1	10.1021/jm00093a025
	CHEMBL98334	208178	1	None	-	1	Guinea pig	4.6	pIC50	=	4.6	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	294	6	0	4	2.2	COc1cccc(C2SCC(=O)N2CCCN(C)C)c1	10.1021/jm00093a025
	145993117	166921	0	None	-204	6	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	427	7	0	5	4.4	CCC1(C)CC(=O)N(CCCCN2CCN(c3cccc4sccc34)CC2)C(=O)C1	10.1016/j.ejmech.2017.12.099
	CHEMBL4286717	166921	0	None	-204	6	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	427	7	0	5	4.4	CCC1(C)CC(=O)N(CCCCN2CCN(c3cccc4sccc34)CC2)C(=O)C1	10.1016/j.ejmech.2017.12.099
	708981	88792	2	None	-	1	Guinea pig	7.6	pIC50	=	7.6	Functional	In vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileumIn vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileum	ChEMBL	295	3	1	3	2.7	CN1CC[C@@](O)(c2ccccc2)[C@H](C(=O)c2ccccc2)C1	10.1016/s0960-894x(00)00199-2
	CHEMBL23638	88792	2	None	-	1	Guinea pig	7.6	pIC50	=	7.6	Functional	In vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileumIn vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileum	ChEMBL	295	3	1	3	2.7	CN1CC[C@@](O)(c2ccccc2)[C@H](C(=O)c2ccccc2)C1	10.1016/s0960-894x(00)00199-2
	13623337	98802	0	None	-	1	Guinea pig	7.6	pIC50	=	7.6	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	300	6	0	4	3.4	CCCCCCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	CHEMBL278457	98802	0	None	-	1	Guinea pig	7.6	pIC50	=	7.6	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	300	6	0	4	3.4	CCCCCCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	15585276	61966	0	None	-	1	Guinea pig	7.6	pIC50	=	7.6	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	364	7	0	5	3.4	CCOCCn1c(N2CCN(Cc3ccccc3)CC2)nc2ccccc21	10.1021/jm00157a010
	CHEMBL17742	61966	0	None	-	1	Guinea pig	7.6	pIC50	=	7.6	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	364	7	0	5	3.4	CCOCCn1c(N2CCN(Cc3ccccc3)CC2)nc2ccccc21	10.1021/jm00157a010
	54582000	62736	5	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	388	4	0	4	4.0	Cc1ccc2c(c1)c1c(n2CCc2cccnc2)CCN(C2CCN(C)CC2)C1	10.1016/j.bmcl.2009.04.128
	CHEMBL1783974	62736	5	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	388	4	0	4	4.0	Cc1ccc2c(c1)c1c(n2CCc2cccnc2)CCN(C2CCN(C)CC2)C1	10.1016/j.bmcl.2009.04.128
	162910	84621	6	None	-	1	Guinea pig	7.6	pIC50	=	7.6	Functional	In vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileumIn vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileum	ChEMBL	261	1	0	1	3.9	CN1CCC2C(=C(c3ccccc3)c3ccccc32)C1	10.1016/s0960-894x(00)00199-2
	CHEMBL22215	84621	6	None	-	1	Guinea pig	7.6	pIC50	=	7.6	Functional	In vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileumIn vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileum	ChEMBL	261	1	0	1	3.9	CN1CCC2C(=C(c3ccccc3)c3ccccc32)C1	10.1016/s0960-894x(00)00199-2
	15542879	112824	0	None	-2	2	Human	6.5	pIC50	=	6.5	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	687	12	0	9	6.3	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccncc4)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	CHEMBL330719	112824	0	None	-2	2	Human	6.5	pIC50	=	6.5	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	687	12	0	9	6.3	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccncc4)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	13623357	63379	0	None	-	1	Guinea pig	6.5	pIC50	=	6.5	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	287	5	1	5	1.4	CCNCCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	CHEMBL17959	63379	0	None	-	1	Guinea pig	6.5	pIC50	=	6.5	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	287	5	1	5	1.4	CCNCCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	10168749	207621	0	None	-3	2	Human	6.5	pIC50	=	6.5	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	676	12	0	9	6.5	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	CHEMBL95127	207621	0	None	-3	2	Human	6.5	pIC50	=	6.5	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	676	12	0	9	6.5	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	1227	2489	43	None	2	14	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human recombinant H1 receptor assessed as inhibition of histamine-induced intracellular Ca2+ releaseAntagonist activity at human recombinant H1 receptor assessed as inhibition of histamine-induced intracellular Ca2+ release	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm401895u
	2331	2489	43	None	2	14	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human recombinant H1 receptor assessed as inhibition of histamine-induced intracellular Ca2+ releaseAntagonist activity at human recombinant H1 receptor assessed as inhibition of histamine-induced intracellular Ca2+ release	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm401895u
	3957	2489	43	None	2	14	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human recombinant H1 receptor assessed as inhibition of histamine-induced intracellular Ca2+ releaseAntagonist activity at human recombinant H1 receptor assessed as inhibition of histamine-induced intracellular Ca2+ release	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm401895u
	4992	2489	43	None	2	14	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human recombinant H1 receptor assessed as inhibition of histamine-induced intracellular Ca2+ releaseAntagonist activity at human recombinant H1 receptor assessed as inhibition of histamine-induced intracellular Ca2+ release	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm401895u
	CHEMBL511	2489	43	None	2	14	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human recombinant H1 receptor assessed as inhibition of histamine-induced intracellular Ca2+ releaseAntagonist activity at human recombinant H1 receptor assessed as inhibition of histamine-induced intracellular Ca2+ release	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm401895u
	DB06691	2489	43	None	2	14	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human recombinant H1 receptor assessed as inhibition of histamine-induced intracellular Ca2+ releaseAntagonist activity at human recombinant H1 receptor assessed as inhibition of histamine-induced intracellular Ca2+ release	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm401895u
	44126326	199619	7	None	32	2	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challenge	ChEMBL	322	3	0	2	4.3	Cc1ccc2c(c1)c1c(n2CCc2ccc(F)cc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
	CHEMBL592753	199619	7	None	32	2	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challenge	ChEMBL	322	3	0	2	4.3	Cc1ccc2c(c1)c1c(n2CCc2ccc(F)cc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
	13623361	64645	0	None	-	1	Guinea pig	7.5	pIC50	=	7.5	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	344	9	0	5	3.4	CCCCCN1CCN(c2nc3ccccc3n2CCOCC)CC1	10.1021/jm00157a010
	CHEMBL18181	64645	0	None	-	1	Guinea pig	7.5	pIC50	=	7.5	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	344	9	0	5	3.4	CCCCCN1CCN(c2nc3ccccc3n2CCOCC)CC1	10.1021/jm00157a010
	145993493	167357	0	None	-38	6	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	439	6	0	5	4.5	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	CHEMBL4294617	167357	0	None	-38	6	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	439	6	0	5	4.5	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	9918576	207337	0	None	-2	3	Human	6.5	pIC50	=	6.5	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	764	14	0	10	7.0	COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC	10.1016/S0960-894X(97)10097-X
	CHEMBL93556	207337	0	None	-2	3	Human	6.5	pIC50	=	6.5	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	764	14	0	10	7.0	COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC	10.1016/S0960-894X(97)10097-X
	44126328	201105	5	None	74	2	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challenge	ChEMBL	322	3	0	2	4.3	Cc1ccc(CCn2c3c(c4cc(F)ccc42)CN(C)CC3)cc1	10.1016/j.bmcl.2009.11.037
	CHEMBL603049	201105	5	None	74	2	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challenge	ChEMBL	322	3	0	2	4.3	Cc1ccc(CCn2c3c(c4cc(F)ccc42)CN(C)CC3)cc1	10.1016/j.bmcl.2009.11.037
	13623363	99036	0	None	-	1	Guinea pig	7.5	pIC50	=	7.5	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	378	8	0	5	3.4	CCOCCn1c(N2CCN(CCc3ccccc3)CC2)nc2ccccc21	10.1021/jm00157a010
	CHEMBL280255	99036	0	None	-	1	Guinea pig	7.5	pIC50	=	7.5	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	378	8	0	5	3.4	CCOCCn1c(N2CCN(CCc3ccccc3)CC2)nc2ccccc21	10.1021/jm00157a010
	14984031	208373	1	None	-	1	Guinea pig	5.5	pIC50	=	5.5	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	282	5	0	3	2.4	CN(C)CCCN1C(=O)CSC1c1cccc(F)c1	10.1021/jm00093a025
	CHEMBL1202933	208373	1	None	-	1	Guinea pig	5.5	pIC50	=	5.5	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	282	5	0	3	2.4	CN(C)CCCN1C(=O)CSC1c1cccc(F)c1	10.1021/jm00093a025
	CHEMBL99529	208373	1	None	-	1	Guinea pig	5.5	pIC50	=	5.5	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	282	5	0	3	2.4	CN(C)CCCN1C(=O)CSC1c1cccc(F)c1	10.1021/jm00093a025
	44126330	62724	5	None	-2	2	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assay	ChEMBL	305	3	0	3	3.6	Cc1ccc2c(c1)c1c(n2CCc2cccnc2)CCN(C)C1	10.1016/j.bmcl.2009.04.128
	CHEMBL1783960	62724	5	None	-2	2	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assay	ChEMBL	305	3	0	3	3.6	Cc1ccc2c(c1)c1c(n2CCc2cccnc2)CCN(C)C1	10.1016/j.bmcl.2009.04.128
	46225027	199117	5	None	74	2	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challenge	ChEMBL	338	4	0	3	4.0	COc1ccc(CCn2c3c(c4cc(F)ccc42)CN(C)CC3)cc1	10.1016/j.bmcl.2009.11.037
	CHEMBL589150	199117	5	None	74	2	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challenge	ChEMBL	338	4	0	3	4.0	COc1ccc(CCn2c3c(c4cc(F)ccc42)CN(C)CC3)cc1	10.1016/j.bmcl.2009.11.037
	54583938	62733	0	None	1	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	306	3	0	4	3.0	Cc1ccc2c(c1)c1c(n2CCc2cnccn2)CCN(C)C1	10.1016/j.bmcl.2009.04.128
	CHEMBL1783970	62733	0	None	1	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	306	3	0	4	3.0	Cc1ccc2c(c1)c1c(n2CCc2cnccn2)CCN(C)C1	10.1016/j.bmcl.2009.04.128
	2773179	98717	5	None	-	1	Guinea pig	6.5	pIC50	=	6.5	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	230	1	0	4	1.3	CN1CCN(c2nc3ccccc3n2C)CC1	10.1021/jm00157a010
	CHEMBL277749	98717	5	None	-	1	Guinea pig	6.5	pIC50	=	6.5	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	230	1	0	4	1.3	CN1CCN(c2nc3ccccc3n2C)CC1	10.1021/jm00157a010
	46224877	200701	5	None	74	2	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challenge	ChEMBL	288	2	0	2	4.3	CN1CCc2c(c3ccccc3n2/C=C\c2ccccc2)C1	10.1016/j.bmcl.2009.11.037
	CHEMBL599913	200701	5	None	74	2	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challenge	ChEMBL	288	2	0	2	4.3	CN1CCc2c(c3ccccc3n2/C=C\c2ccccc2)C1	10.1016/j.bmcl.2009.11.037
	1227	2489	43	None	-2	14	Guinea pig	7.5	pIC50	=	7.5	Functional	In vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileumIn vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileum	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/s0960-894x(00)00199-2
	2331	2489	43	None	-2	14	Guinea pig	7.5	pIC50	=	7.5	Functional	In vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileumIn vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileum	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/s0960-894x(00)00199-2
	3957	2489	43	None	-2	14	Guinea pig	7.5	pIC50	=	7.5	Functional	In vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileumIn vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileum	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/s0960-894x(00)00199-2
	4992	2489	43	None	-2	14	Guinea pig	7.5	pIC50	=	7.5	Functional	In vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileumIn vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileum	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/s0960-894x(00)00199-2
	CHEMBL511	2489	43	None	-2	14	Guinea pig	7.5	pIC50	=	7.5	Functional	In vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileumIn vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileum	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/s0960-894x(00)00199-2
	DB06691	2489	43	None	-2	14	Guinea pig	7.5	pIC50	=	7.5	Functional	In vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileumIn vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileum	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/s0960-894x(00)00199-2
	10123040	161095	0	None	-7	2	Human	5.5	pIC50	=	5.5	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	730	13	1	9	6.6	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	CHEMBL411691	161095	0	None	-7	2	Human	5.5	pIC50	=	5.5	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	730	13	1	9	6.6	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	CHEMBL537027	161095	0	None	-7	2	Human	5.5	pIC50	=	5.5	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	730	13	1	9	6.6	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	46224878	199469	0	None	2	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challenge	ChEMBL	290	2	0	2	4.0	CN1CCC2C(C1)c1ccccc1N2/C=C/c1ccccc1	10.1016/j.bmcl.2009.11.037
	CHEMBL591568	199469	0	None	2	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challenge	ChEMBL	290	2	0	2	4.0	CN1CCC2C(C1)c1ccccc1N2/C=C/c1ccccc1	10.1016/j.bmcl.2009.11.037
	46225002	199494	5	None	602	2	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challenge	ChEMBL	376	3	0	2	5.0	CN1CCc2c(c3cc(F)ccc3n2CCc2ccc(C(F)(F)F)cc2)C1	10.1016/j.bmcl.2009.11.037
	CHEMBL591803	199494	5	None	602	2	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challenge	ChEMBL	376	3	0	2	5.0	CN1CCc2c(c3cc(F)ccc3n2CCc2ccc(C(F)(F)F)cc2)C1	10.1016/j.bmcl.2009.11.037
	11291	98796	25	None	223	3	Guinea pig	7.4	pIC50	=	7.4	Functional	In vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileumIn vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileum	ChEMBL	261	1	0	1	3.9	CN1CCC2=C(C1)C(c1ccccc1)c1ccccc12	10.1016/s0960-894x(00)00199-2
	CHEMBL278398	98796	25	None	223	3	Guinea pig	7.4	pIC50	=	7.4	Functional	In vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileumIn vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileum	ChEMBL	261	1	0	1	3.9	CN1CCC2=C(C1)C(c1ccccc1)c1ccccc12	10.1016/s0960-894x(00)00199-2
	10233656	207851	0	None	-3	2	Human	6.4	pIC50	=	6.4	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	687	12	0	9	6.3	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	CHEMBL96442	207851	0	None	-3	2	Human	6.4	pIC50	=	6.4	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	687	12	0	9	6.3	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	13623343	98501	0	None	-	1	Guinea pig	7.4	pIC50	=	7.4	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	316	7	0	5	2.6	CCCCOCCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	CHEMBL276070	98501	0	None	-	1	Guinea pig	7.4	pIC50	=	7.4	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	316	7	0	5	2.6	CCCCOCCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	13623334	63923	0	None	-	1	Guinea pig	6.4	pIC50	=	6.4	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	258	3	0	4	2.2	CCCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	CHEMBL18062	63923	0	None	-	1	Guinea pig	6.4	pIC50	=	6.4	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	258	3	0	4	2.2	CCCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	10122529	109556	0	None	-3	2	Human	6.4	pIC50	=	6.4	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	668	14	0	9	5.9	CCOCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21	10.1016/S0960-894X(97)10097-X
	CHEMBL322194	109556	0	None	-3	2	Human	6.4	pIC50	=	6.4	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	668	14	0	9	5.9	CCOCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21	10.1016/S0960-894X(97)10097-X
	54581997	62730	6	None	11	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	321	4	0	4	3.3	COc1ccc2c(c1)c1c(n2CCc2ccncc2)CCN(C)C1	10.1016/j.bmcl.2009.04.128
	CHEMBL1783966	62730	6	None	11	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	321	4	0	4	3.3	COc1ccc2c(c1)c1c(n2CCc2ccncc2)CCN(C)C1	10.1016/j.bmcl.2009.04.128
	621659	62729	10	None	-2	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assay	ChEMBL	305	3	0	3	3.6	Cc1ccc2c(c1)c1c(n2CCc2ccncc2)CCN(C)C1	10.1016/j.bmcl.2009.04.128
	CHEMBL1783965	62729	10	None	-2	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assay	ChEMBL	305	3	0	3	3.6	Cc1ccc2c(c1)c1c(n2CCc2ccncc2)CCN(C)C1	10.1016/j.bmcl.2009.04.128
	10123040	161095	0	None	-7	2	Human	8.4	pIC50	=	8.4	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	730	13	1	9	6.6	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	CHEMBL411691	161095	0	None	-7	2	Human	8.4	pIC50	=	8.4	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	730	13	1	9	6.6	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	CHEMBL537027	161095	0	None	-7	2	Human	8.4	pIC50	=	8.4	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	730	13	1	9	6.6	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	10212725	98169	0	None	1	2	Human	8.3	pIC50	=	8.3	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	790	15	1	11	6.6	COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC	10.1016/S0960-894X(97)10098-1
	CHEMBL273915	98169	0	None	1	2	Human	8.3	pIC50	=	8.3	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	790	15	1	11	6.6	COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC	10.1016/S0960-894X(97)10098-1
	46225000	199115	5	None	9	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challenge	ChEMBL	308	3	0	2	4.0	CN1CCc2c(c3cc(F)ccc3n2CCc2ccccc2)C1	10.1016/j.bmcl.2009.11.037
	CHEMBL589148	199115	5	None	9	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challenge	ChEMBL	308	3	0	2	4.0	CN1CCc2c(c3cc(F)ccc3n2CCc2ccccc2)C1	10.1016/j.bmcl.2009.11.037
	42631003	199618	13	None	2	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challenge	ChEMBL	304	3	0	2	4.2	Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
	CHEMBL592752	199618	13	None	2	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challenge	ChEMBL	304	3	0	2	4.2	Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
	14984030	107330	1	None	-	1	Guinea pig	4.4	pIC50	=	4.4	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	279	5	1	4	1.8	CN(C)CCCN1C(=O)CSC1c1ccc(N)cc1	10.1021/jm00093a025
	CHEMBL1202935	107330	1	None	-	1	Guinea pig	4.4	pIC50	=	4.4	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	279	5	1	4	1.8	CN(C)CCCN1C(=O)CSC1c1ccc(N)cc1	10.1021/jm00093a025
	CHEMBL317518	107330	1	None	-	1	Guinea pig	4.4	pIC50	=	4.4	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	279	5	1	4	1.8	CN(C)CCCN1C(=O)CSC1c1ccc(N)cc1	10.1021/jm00093a025
	44224259	62723	5	None	30	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assay	ChEMBL	291	3	0	3	3.3	CN1CCc2c(c3ccccc3n2CCc2cccnc2)C1	10.1016/j.bmcl.2009.04.128
	CHEMBL1783959	62723	5	None	30	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assay	ChEMBL	291	3	0	3	3.3	CN1CCc2c(c3ccccc3n2CCc2cccnc2)C1	10.1016/j.bmcl.2009.04.128
	13623358	98738	1	None	-	1	Guinea pig	6.4	pIC50	=	6.4	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	260	3	1	5	0.8	CN1CCN(c2nc3ccccc3n2CCO)CC1	10.1021/jm00157a010
	CHEMBL277956	98738	1	None	-	1	Guinea pig	6.4	pIC50	=	6.4	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	260	3	1	5	0.8	CN1CCN(c2nc3ccccc3n2CCO)CC1	10.1021/jm00157a010
	15542881	112591	0	None	-3	2	Human	6.4	pIC50	=	6.4	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	687	12	0	9	6.3	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4cccnc4)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	CHEMBL330172	112591	0	None	-3	2	Human	6.4	pIC50	=	6.4	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	687	12	0	9	6.3	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4cccnc4)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	145966333	164060	0	None	-346	6	Human	6.4	pIC50	=	6.4	Functional	Antagonistic activity at histamine 1 receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at histamine 1 receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	424	8	1	6	3.6	CNC(=O)c1cc(OCCCCN2CCN(c3cccc4sccc34)CC2)ccn1	10.1016/j.bmcl.2018.01.038
	CHEMBL4209188	164060	0	None	-346	6	Human	6.4	pIC50	=	6.4	Functional	Antagonistic activity at histamine 1 receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at histamine 1 receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	424	8	1	6	3.6	CNC(=O)c1cc(OCCCCN2CCN(c3cccc4sccc34)CC2)ccn1	10.1016/j.bmcl.2018.01.038
	13623355	64344	0	None	-	1	Guinea pig	7.4	pIC50	=	7.4	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	304	6	1	6	0.8	CN1CCN(c2nc3ccccc3n2CCOCCO)CC1	10.1021/jm00157a010
	CHEMBL18122	64344	0	None	-	1	Guinea pig	7.4	pIC50	=	7.4	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	304	6	1	6	0.8	CN1CCN(c2nc3ccccc3n2CCOCCO)CC1	10.1021/jm00157a010
	242	470	124	None	-97	33	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2017.12.099
	34	470	124	None	-97	33	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2017.12.099
	60795	470	124	None	-97	33	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2017.12.099
	CHEMBL1112	470	124	None	-97	33	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2017.12.099
	DB01238	470	124	None	-97	33	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2017.12.099
	242	470	124	None	-97	33	Human	6.4	pIC50	=	6.4	Functional	Antagonistic activity at histamine 1 receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at histamine 1 receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2018.01.038
	34	470	124	None	-97	33	Human	6.4	pIC50	=	6.4	Functional	Antagonistic activity at histamine 1 receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at histamine 1 receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2018.01.038
	60795	470	124	None	-97	33	Human	6.4	pIC50	=	6.4	Functional	Antagonistic activity at histamine 1 receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at histamine 1 receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2018.01.038
	CHEMBL1112	470	124	None	-97	33	Human	6.4	pIC50	=	6.4	Functional	Antagonistic activity at histamine 1 receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at histamine 1 receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2018.01.038
	DB01238	470	124	None	-97	33	Human	6.4	pIC50	=	6.4	Functional	Antagonistic activity at histamine 1 receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at histamine 1 receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2018.01.038
	13623339	63295	0	None	-	1	Guinea pig	5.4	pIC50	=	5.4	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	356	10	0	4	4.9	CCCCCCCCCCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	CHEMBL17931	63295	0	None	-	1	Guinea pig	5.4	pIC50	=	5.4	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	356	10	0	4	4.9	CCCCCCCCCCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	13623356	62492	0	None	-	1	Guinea pig	6.4	pIC50	=	6.4	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	350	6	0	5	3.0	CN1CCN(c2nc3ccccc3n2CCOCc2ccccc2)CC1	10.1021/jm00157a010
	CHEMBL17808	62492	0	None	-	1	Guinea pig	6.4	pIC50	=	6.4	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	350	6	0	5	3.0	CN1CCN(c2nc3ccccc3n2CCOCc2ccccc2)CC1	10.1021/jm00157a010
	10283825	96693	0	None	-1	2	Human	6.4	pIC50	=	6.4	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	740	12	0	8	7.3	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(F)cc3F)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	CHEMBL264007	96693	0	None	-1	2	Human	6.4	pIC50	=	6.4	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	740	12	0	8	7.3	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(F)cc3F)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	10147107	207620	0	None	-3	2	Human	6.4	pIC50	=	6.4	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	755	12	0	9	7.6	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	CHEMBL431850	207620	0	None	-3	2	Human	6.4	pIC50	=	6.4	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	755	12	0	9	7.6	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	CHEMBL95125	207620	0	None	-3	2	Human	6.4	pIC50	=	6.4	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	755	12	0	9	7.6	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	145964299	164132	0	None	-489	6	Human	5.4	pIC50	=	5.4	Functional	Antagonistic activity at histamine 1 receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at histamine 1 receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	426	8	1	6	3.8	CNC(=O)c1cc(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)ccn1	10.1016/j.bmcl.2018.01.038
	CHEMBL4210030	164132	0	None	-489	6	Human	5.4	pIC50	=	5.4	Functional	Antagonistic activity at histamine 1 receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at histamine 1 receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	426	8	1	6	3.8	CNC(=O)c1cc(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)ccn1	10.1016/j.bmcl.2018.01.038
	44327909	112358	0	None	-37	2	Human	6.4	pIC50	=	6.4	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	706	14	0	10	6.5	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCOc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	CHEMBL329450	112358	0	None	-37	2	Human	6.4	pIC50	=	6.4	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	706	14	0	10	6.5	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCOc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	736282	78142	12	None	-3	2	Human	4.4	pIC50	=	4.4	Functional	Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assayAntagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assay	ChEMBL	337	6	1	3	4.2	CN1[C@H](CC(=O)c2ccccc2)CCC[C@@H]1C[C@H](O)c1ccccc1	10.1021/jm300671m
	CHEMBL2103769	78142	12	None	-3	2	Human	4.4	pIC50	=	4.4	Functional	Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assayAntagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assay	ChEMBL	337	6	1	3	4.2	CN1[C@H](CC(=O)c2ccccc2)CCC[C@@H]1C[C@H](O)c1ccccc1	10.1021/jm300671m
	2389	3331	118	None	-234	29	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2017.12.099
	5073	3331	118	None	-234	29	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2017.12.099
	96	3331	118	None	-234	29	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2017.12.099
	CHEMBL85	3331	118	None	-234	29	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2017.12.099
	DB00734	3331	118	None	-234	29	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2017.12.099
	2389	3331	118	None	-234	29	Human	6.3	pIC50	=	6.3	Functional	Antagonistic activity at histamine 1 receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at histamine 1 receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2018.01.038
	5073	3331	118	None	-234	29	Human	6.3	pIC50	=	6.3	Functional	Antagonistic activity at histamine 1 receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at histamine 1 receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2018.01.038
	96	3331	118	None	-234	29	Human	6.3	pIC50	=	6.3	Functional	Antagonistic activity at histamine 1 receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at histamine 1 receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2018.01.038
	CHEMBL85	3331	118	None	-234	29	Human	6.3	pIC50	=	6.3	Functional	Antagonistic activity at histamine 1 receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at histamine 1 receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2018.01.038
	DB00734	3331	118	None	-234	29	Human	6.3	pIC50	=	6.3	Functional	Antagonistic activity at histamine 1 receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at histamine 1 receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2018.01.038
	1227	2489	43	None	2	14	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assayAntagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assay	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm300671m
	2331	2489	43	None	2	14	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assayAntagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assay	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm300671m
	3957	2489	43	None	2	14	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assayAntagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assay	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm300671m
	4992	2489	43	None	2	14	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assayAntagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assay	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm300671m
	CHEMBL511	2489	43	None	2	14	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assayAntagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assay	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm300671m
	DB06691	2489	43	None	2	14	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assayAntagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assay	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm300671m
	75201901	166425	19	None	-208	4	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
	CHEMBL4277264	166425	19	None	-208	4	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
	54582938	62719	6	None	1	2	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	321	4	0	4	3.3	COc1ccc2c(c1)c1c(n2CCc2ccccn2)CCN(C)C1	10.1016/j.bmcl.2009.04.128
	CHEMBL1783955	62719	6	None	1	2	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	321	4	0	4	3.3	COc1ccc2c(c1)c1c(n2CCc2ccccn2)CCN(C)C1	10.1016/j.bmcl.2009.04.128
	54580942	62731	9	None	13	2	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assay	ChEMBL	309	3	0	3	3.4	CN1CCc2c(c3cc(F)ccc3n2CCc2ccncc2)C1	10.1016/j.bmcl.2009.04.128
	CHEMBL1783967	62731	9	None	13	2	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assay	ChEMBL	309	3	0	3	3.4	CN1CCc2c(c3cc(F)ccc3n2CCc2ccncc2)C1	10.1016/j.bmcl.2009.04.128
	10315027	98929	0	None	-	1	Guinea pig	6.3	pIC50	=	6.3	Functional	In vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileumIn vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileum	ChEMBL	337	3	0	1	5.5	c1ccc(CN2CCC3=C(C2)C(c2ccccc2)c2ccccc23)cc1	10.1016/s0960-894x(00)00199-2
	CHEMBL279454	98929	0	None	-	1	Guinea pig	6.3	pIC50	=	6.3	Functional	In vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileumIn vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileum	ChEMBL	337	3	0	1	5.5	c1ccc(CN2CCC3=C(C2)C(c2ccccc2)c2ccccc23)cc1	10.1016/s0960-894x(00)00199-2
	15542673	207564	0	None	-1	2	Human	6.3	pIC50	=	6.3	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	772	12	0	8	8.0	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(C(F)(F)F)cc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	CHEMBL94834	207564	0	None	-1	2	Human	6.3	pIC50	=	6.3	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	772	12	0	8	8.0	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(C(F)(F)F)cc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	10305888	207555	0	None	1	2	Human	8.3	pIC50	=	8.3	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	750	14	1	9	7.0	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCC(=O)O)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	CHEMBL94788	207555	0	None	1	2	Human	8.3	pIC50	=	8.3	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	750	14	1	9	7.0	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCC(=O)O)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	44328321	167788	0	None	1	2	Human	8.3	pIC50	=	8.3	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	788	17	1	10	7.4	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	CHEMBL430471	167788	0	None	1	2	Human	8.3	pIC50	=	8.3	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	788	17	1	10	7.4	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	10305069	207850	0	None	1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	656	12	1	9	5.4	COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC	10.1016/S0960-894X(97)10098-1
	CHEMBL96441	207850	0	None	1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	656	12	1	9	5.4	COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC	10.1016/S0960-894X(97)10098-1
	10234086	111634	0	None	-6	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	744	13	0	10	6.7	COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccccc5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1	10.1016/S0960-894X(97)10098-1
	CHEMBL328511	111634	0	None	-6	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	744	13	0	10	6.7	COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccccc5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1	10.1016/S0960-894X(97)10098-1
	13623335	98801	0	None	-	1	Guinea pig	7.3	pIC50	=	7.3	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	272	4	0	4	2.6	CCCCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	CHEMBL278456	98801	0	None	-	1	Guinea pig	7.3	pIC50	=	7.3	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	272	4	0	4	2.6	CCCCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	10121390	112739	0	None	-3	2	Human	6.3	pIC50	=	6.3	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	596	10	1	7	5.4	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	CHEMBL330499	112739	0	None	-3	2	Human	6.3	pIC50	=	6.3	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	596	10	1	7	5.4	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	10190413	207329	0	None	-3	2	Human	6.3	pIC50	=	6.3	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	717	13	0	10	6.3	COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1	10.1016/S0960-894X(97)10097-X
	CHEMBL410270	207329	0	None	-3	2	Human	6.3	pIC50	=	6.3	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	717	13	0	10	6.3	COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1	10.1016/S0960-894X(97)10097-X
	CHEMBL93519	207329	0	None	-3	2	Human	6.3	pIC50	=	6.3	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	717	13	0	10	6.3	COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1	10.1016/S0960-894X(97)10097-X
	54579957	62728	5	None	36	2	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assay	ChEMBL	291	3	0	3	3.3	CN1CCc2c(c3ccccc3n2CCc2ccncc2)C1	10.1016/j.bmcl.2009.04.128
	CHEMBL1783964	62728	5	None	36	2	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assay	ChEMBL	291	3	0	3	3.3	CN1CCc2c(c3ccccc3n2CCc2ccncc2)C1	10.1016/j.bmcl.2009.04.128
	44126329	62718	6	None	-2	2	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	305	3	0	3	3.6	Cc1ccc2c(c1)c1c(n2CCc2ccccn2)CCN(C)C1	10.1016/j.bmcl.2009.04.128
	CHEMBL1783954	62718	6	None	-2	2	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	305	3	0	3	3.6	Cc1ccc2c(c1)c1c(n2CCc2ccccn2)CCN(C)C1	10.1016/j.bmcl.2009.04.128
	44126330	62724	5	None	-2	2	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	305	3	0	3	3.6	Cc1ccc2c(c1)c1c(n2CCc2cccnc2)CCN(C)C1	10.1016/j.bmcl.2009.04.128
	CHEMBL1783960	62724	5	None	-2	2	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	305	3	0	3	3.6	Cc1ccc2c(c1)c1c(n2CCc2cccnc2)CCN(C)C1	10.1016/j.bmcl.2009.04.128
	13623348	59042	0	None	-	1	Guinea pig	6.3	pIC50	=	6.3	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	300	5	0	4	3.2	CCCC(C)Cn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	CHEMBL16939	59042	0	None	-	1	Guinea pig	6.3	pIC50	=	6.3	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	300	5	0	4	3.2	CCCC(C)Cn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	10423703	107295	0	None	-	1	Guinea pig	5.3	pIC50	=	5.3	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	278	5	0	3	2.5	Cc1cccc(C2SCC(=O)N2CCCN(C)C)c1	10.1021/jm00093a025
	CHEMBL1202942	107295	0	None	-	1	Guinea pig	5.3	pIC50	=	5.3	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	278	5	0	3	2.5	Cc1cccc(C2SCC(=O)N2CCCN(C)C)c1	10.1021/jm00093a025
	CHEMBL317171	107295	0	None	-	1	Guinea pig	5.3	pIC50	=	5.3	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	278	5	0	3	2.5	Cc1cccc(C2SCC(=O)N2CCCN(C)C)c1	10.1021/jm00093a025
	10300214	84199	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	492	9	2	5	5.0	O=C(Nc1ccccc1OCC(O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)C1CCC1	10.1016/j.bmcl.2012.09.113
	CHEMBL2208416	84199	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	492	9	2	5	5.0	O=C(Nc1ccccc1OCC(O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)C1CCC1	10.1016/j.bmcl.2012.09.113
	15830914	98906	0	None	-	1	Guinea pig	7.3	pIC50	=	7.3	Functional	In vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileumIn vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileum	ChEMBL	245	1	1	1	3.5	C1=C2C(=C(c3ccccc3)c3ccccc32)CNC1	10.1016/s0960-894x(00)00199-2
	CHEMBL279297	98906	0	None	-	1	Guinea pig	7.3	pIC50	=	7.3	Functional	In vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileumIn vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileum	ChEMBL	245	1	1	1	3.5	C1=C2C(=C(c3ccccc3)c3ccccc32)CNC1	10.1016/s0960-894x(00)00199-2
	13623351	61156	0	None	-	1	Guinea pig	6.3	pIC50	=	6.3	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	318	6	0	5	2.9	CCSCCCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	CHEMBL17655	61156	0	None	-	1	Guinea pig	6.3	pIC50	=	6.3	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	318	6	0	5	2.9	CCSCCCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	54582940	62722	5	None	1	2	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	359	3	0	3	4.3	CN1CCc2c(c3cc(C(F)(F)F)ccc3n2CCc2ccccn2)C1	10.1016/j.bmcl.2009.04.128
	CHEMBL1783958	62722	5	None	1	2	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	359	3	0	3	4.3	CN1CCc2c(c3cc(C(F)(F)F)ccc3n2CCc2ccccn2)C1	10.1016/j.bmcl.2009.04.128
	2600	3779	74	None	4	32	Human	6.3	pIC50	=	6.3	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1016/S0960-894X(97)10097-X
	2608	3779	74	None	4	32	Human	6.3	pIC50	=	6.3	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1016/S0960-894X(97)10097-X
	5405	3779	74	None	4	32	Human	6.3	pIC50	=	6.3	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1016/S0960-894X(97)10097-X
	CHEMBL17157	3779	74	None	4	32	Human	6.3	pIC50	=	6.3	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1016/S0960-894X(97)10097-X
	DB00342	3779	74	None	4	32	Human	6.3	pIC50	=	6.3	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1016/S0960-894X(97)10097-X
	10917690	207605	1	None	-3	4	Human	7.2	pIC50	=	7.2	Functional	Compound was evaluated for the antagonistic activity against H1 receptorCompound was evaluated for the antagonistic activity against H1 receptor	ChEMBL	471	8	0	5	5.4	COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1	10.1016/S0960-894X(97)10097-X
	CHEMBL95051	207605	1	None	-3	4	Human	7.2	pIC50	=	7.2	Functional	Compound was evaluated for the antagonistic activity against H1 receptorCompound was evaluated for the antagonistic activity against H1 receptor	ChEMBL	471	8	0	5	5.4	COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1	10.1016/S0960-894X(97)10097-X
	44328320	207601	0	None	1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	802	17	0	11	7.5	COC(=O)c1ccccc1OCCCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21	10.1016/S0960-894X(97)10098-1
	CHEMBL95029	207601	0	None	1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	802	17	0	11	7.5	COC(=O)c1ccccc1OCCCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21	10.1016/S0960-894X(97)10098-1
	10147218	107466	0	None	1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	778	15	0	10	7.5	CCOC(=O)CCCn1c(C(=O)C2CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21	10.1016/S0960-894X(97)10098-1
	CHEMBL318369	107466	0	None	1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	778	15	0	10	7.5	CCOC(=O)CCCn1c(C(=O)C2CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21	10.1016/S0960-894X(97)10098-1
	10169609	207645	0	None	1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	804	15	0	12	6.7	COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccc(OC)c(OC)c5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1	10.1016/S0960-894X(97)10098-1
	CHEMBL95243	207645	0	None	1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	804	15	0	12	6.7	COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccc(OC)c(OC)c5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1	10.1016/S0960-894X(97)10098-1
	3219	199795	60	None	-	1	Guinea pig	8.2	pIC50	=	8.2	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	302	5	0	5	2.2	CCOCCn1c(N2CCCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	CHEMBL594	199795	60	None	-	1	Guinea pig	8.2	pIC50	=	8.2	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	302	5	0	5	2.2	CCOCCn1c(N2CCCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	44328188	111526	0	None	1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	728	16	0	11	5.9	CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(OC)c(OC)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21	10.1016/S0960-894X(97)10098-1
	CHEMBL327888	111526	0	None	1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	728	16	0	11	5.9	CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(OC)c(OC)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21	10.1016/S0960-894X(97)10098-1
	15542880	207506	0	None	1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	705	12	0	9	6.4	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(F)cc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	CHEMBL94480	207506	0	None	1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	705	12	0	9	6.4	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(F)cc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	10284042	207986	0	None	1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	777	13	0	10	6.5	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCN4CCOCC4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	CHEMBL97240	207986	0	None	1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	777	13	0	10	6.5	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCN4CCOCC4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	10121390	112739	0	None	-3	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	596	10	1	7	5.4	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	CHEMBL330499	112739	0	None	-3	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	596	10	1	7	5.4	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	10190413	207329	0	None	-3	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	717	13	0	10	6.3	COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1	10.1016/S0960-894X(97)10098-1
	CHEMBL410270	207329	0	None	-3	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	717	13	0	10	6.3	COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1	10.1016/S0960-894X(97)10098-1
	CHEMBL93519	207329	0	None	-3	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	717	13	0	10	6.3	COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1	10.1016/S0960-894X(97)10098-1
	15542673	207564	0	None	-1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	772	12	0	8	8.0	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(C(F)(F)F)cc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	CHEMBL94834	207564	0	None	-1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	772	12	0	8	8.0	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(C(F)(F)F)cc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	15542869	207609	0	None	1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	720	15	0	10	6.6	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCOCc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	CHEMBL95076	207609	0	None	1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	720	15	0	10	6.6	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCOCc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	10283825	96693	0	None	-1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	740	12	0	8	7.3	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(F)cc3F)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	CHEMBL264007	96693	0	None	-1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	740	12	0	8	7.3	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(F)cc3F)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	10147107	207620	0	None	-3	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	755	12	0	9	7.6	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	CHEMBL431850	207620	0	None	-3	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	755	12	0	9	7.6	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	CHEMBL95125	207620	0	None	-3	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	755	12	0	9	7.6	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	15542881	112591	0	None	-3	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	687	12	0	9	6.3	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4cccnc4)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	CHEMBL330172	112591	0	None	-3	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	687	12	0	9	6.3	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4cccnc4)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	15542679	108527	0	None	1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	664	10	1	7	6.7	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	CHEMBL320003	108527	0	None	1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	664	10	1	7	6.7	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	10122529	109556	0	None	-3	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	668	14	0	9	5.9	CCOCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21	10.1016/S0960-894X(97)10098-1
	CHEMBL322194	109556	0	None	-3	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	668	14	0	9	5.9	CCOCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21	10.1016/S0960-894X(97)10098-1
	10233656	207851	0	None	-3	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	687	12	0	9	6.3	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	CHEMBL96442	207851	0	None	-3	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	687	12	0	9	6.3	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	18333241	207793	0	None	1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	736	14	0	9	7.2	CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21	10.1016/S0960-894X(97)10098-1
	CHEMBL96141	207793	0	None	1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	736	14	0	9	7.2	CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21	10.1016/S0960-894X(97)10098-1
	9918576	207337	0	None	-2	3	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	764	14	0	10	7.0	COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC	10.1016/S0960-894X(97)10098-1
	CHEMBL93556	207337	0	None	-2	3	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	764	14	0	10	7.0	COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC	10.1016/S0960-894X(97)10098-1
	10168749	207621	0	None	-3	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	676	12	0	9	6.5	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	CHEMBL95127	207621	0	None	-3	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	676	12	0	9	6.5	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	15542879	112824	0	None	-2	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	687	12	0	9	6.3	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccncc4)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	CHEMBL330719	112824	0	None	-2	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	687	12	0	9	6.3	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccncc4)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	10190770	208015	0	None	-1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	772	12	0	8	8.3	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	CHEMBL330430	208015	0	None	-1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	772	12	0	8	8.3	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	CHEMBL97357	208015	0	None	-1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	772	12	0	8	8.3	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	10190638	207542	0	None	-1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	748	12	0	10	6.7	COc1ccc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)c(OC)c1OC	10.1016/S0960-894X(97)10098-1
	CHEMBL94726	207542	0	None	-1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	748	12	0	10	6.7	COc1ccc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)c(OC)c1OC	10.1016/S0960-894X(97)10098-1
	10283765	108087	0	None	1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	730	12	0	8	7.4	CC(C)Oc1cccc(CC(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)c1	10.1016/S0960-894X(97)10098-1
	CHEMBL319535	108087	0	None	1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	730	12	0	8	7.4	CC(C)Oc1cccc(CC(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)c1	10.1016/S0960-894X(97)10098-1
	18333379	207575	0	None	1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	686	15	0	9	5.9	CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(F)cc4)CCN(Cc4cc(OC)c(OC)c(OC)c4)C3=O)CC2)nc2ccccc21	10.1016/S0960-894X(97)10098-1
	CHEMBL94906	207575	0	None	1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	686	15	0	9	5.9	CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(F)cc4)CCN(Cc4cc(OC)c(OC)c(OC)c4)C3=O)CC2)nc2ccccc21	10.1016/S0960-894X(97)10098-1
	10190056	111438	0	None	1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	674	11	0	7	7.0	COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3ccccc3)C2)cc1OC	10.1016/S0960-894X(97)10098-1
	CHEMBL327497	111438	0	None	1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	674	11	0	7	7.0	COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3ccccc3)C2)cc1OC	10.1016/S0960-894X(97)10098-1
	10212223	208140	0	None	-2	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	704	12	0	8	7.0	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	CHEMBL431458	208140	0	None	-2	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	704	12	0	8	7.0	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	CHEMBL98079	208140	0	None	-2	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	704	12	0	8	7.0	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	15542874	112169	0	None	1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	786	12	0	8	8.7	COc1cc(C(=O)N2CCCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	CHEMBL329055	112169	0	None	1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	786	12	0	8	8.7	COc1cc(C(=O)N2CCCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	10123138	108526	0	None	-1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	748	12	0	10	6.7	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	CHEMBL317524	108526	0	None	-1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	748	12	0	10	6.7	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	CHEMBL320002	108526	0	None	-1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	748	12	0	10	6.7	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10098-1
	9832306	112724	0	None	2	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	806	17	0	10	8.2	CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC	10.1016/S0960-894X(97)10098-1
	CHEMBL330367	112724	0	None	2	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	806	17	0	10	8.2	CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC	10.1016/S0960-894X(97)10098-1
	CHEMBL330462	112724	0	None	2	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	806	17	0	10	8.2	CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC	10.1016/S0960-894X(97)10098-1
	15542871	207855	0	None	-1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	726	9	0	7	8.0	O=C(c1nc2ccccc2n1Cc1ccc(F)cc1)C1CCN(CCC2(c3ccc4c(c3)OCO4)CCN(C(=O)c3ccc(Cl)cc3Cl)C2)CC1	10.1016/S0960-894X(97)10098-1
	CHEMBL96466	207855	0	None	-1	2	Human	8.2	pIC50	=	8.2	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	726	9	0	7	8.0	O=C(c1nc2ccccc2n1Cc1ccc(F)cc1)C1CCN(CCC2(c3ccc4c(c3)OCO4)CCN(C(=O)c3ccc(Cl)cc3Cl)C2)CC1	10.1016/S0960-894X(97)10098-1
	3071016	98578	1	None	-	1	Guinea pig	8.2	pIC50	=	8.2	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	336	5	0	5	2.9	CN1CCN(c2nc3ccccc3n2CCOc2ccccc2)CC1	10.1021/jm00157a010
	CHEMBL276735	98578	1	None	-	1	Guinea pig	8.2	pIC50	=	8.2	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	336	5	0	5	2.9	CN1CCN(c2nc3ccccc3n2CCOc2ccccc2)CC1	10.1021/jm00157a010
	14984032	208341	1	None	-	1	Guinea pig	4.2	pIC50	=	4.2	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	342	5	0	3	3.0	CN(C)CCCN1C(=O)CSC1c1cccc(Br)c1	10.1021/jm00093a025
	CHEMBL1202932	208341	1	None	-	1	Guinea pig	4.2	pIC50	=	4.2	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	342	5	0	3	3.0	CN(C)CCCN1C(=O)CSC1c1cccc(Br)c1	10.1021/jm00093a025
	CHEMBL99350	208341	1	None	-	1	Guinea pig	4.2	pIC50	=	4.2	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	342	5	0	3	3.0	CN(C)CCCN1C(=O)CSC1c1cccc(Br)c1	10.1021/jm00093a025
	54579956	62720	5	None	3	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assay	ChEMBL	309	3	0	3	3.4	CN1CCc2c(c3cc(F)ccc3n2CCc2ccccn2)C1	10.1016/j.bmcl.2009.04.128
	CHEMBL1783956	62720	5	None	3	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assay	ChEMBL	309	3	0	3	3.4	CN1CCc2c(c3cc(F)ccc3n2CCc2ccccn2)C1	10.1016/j.bmcl.2009.04.128
	54586813	62725	5	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	309	3	0	3	3.4	CN1CCc2c(c3cc(F)ccc3n2CCc2cccnc2)C1	10.1016/j.bmcl.2009.04.128
	CHEMBL1783961	62725	5	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	309	3	0	3	3.4	CN1CCc2c(c3cc(F)ccc3n2CCc2cccnc2)C1	10.1016/j.bmcl.2009.04.128
	44126325	199114	5	None	10	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challenge	ChEMBL	334	4	0	3	4.2	COc1ccc(CCn2c3c(c4cc(C)ccc42)CN(C)CC3)cc1	10.1016/j.bmcl.2009.11.037
	CHEMBL589147	199114	5	None	10	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challenge	ChEMBL	334	4	0	3	4.2	COc1ccc(CCn2c3c(c4cc(C)ccc42)CN(C)CC3)cc1	10.1016/j.bmcl.2009.11.037
	44126272	199150	5	None	14	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challenge	ChEMBL	358	3	0	2	4.9	CN1CCc2c(c3cc(C(F)(F)F)ccc3n2CCc2ccccc2)C1	10.1016/j.bmcl.2009.11.037
	CHEMBL589388	199150	5	None	14	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challenge	ChEMBL	358	3	0	2	4.9	CN1CCc2c(c3cc(C(F)(F)F)ccc3n2CCc2ccccc2)C1	10.1016/j.bmcl.2009.11.037
	13623349	98583	0	None	-	1	Guinea pig	7.2	pIC50	=	7.2	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	304	5	0	5	2.9	CCCSCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	CHEMBL276774	98583	0	None	-	1	Guinea pig	7.2	pIC50	=	7.2	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	304	5	0	5	2.9	CCCSCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	16082828	80260	0	None	-398	3	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human H1 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assayAntagonist activity at human H1 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assay	ChEMBL	275	6	2	2	3.3	Clc1ccc(CNCC[C@@H]2C[C@H]2c2c[nH]cn2)cc1	10.1021/jm0603318
	CHEMBL213886	80260	0	None	-398	3	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human H1 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assayAntagonist activity at human H1 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assay	ChEMBL	275	6	2	2	3.3	Clc1ccc(CNCC[C@@H]2C[C@H]2c2c[nH]cn2)cc1	10.1021/jm0603318
	10917690	207605	1	None	-3	4	Human	8.1	pIC50	=	8.1	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	471	8	0	5	5.4	COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1	10.1016/S0960-894X(97)10098-1
	CHEMBL95051	207605	1	None	-3	4	Human	8.1	pIC50	=	8.1	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	471	8	0	5	5.4	COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1	10.1016/S0960-894X(97)10098-1
	44328187	208139	0	None	-1	2	Human	8.1	pIC50	=	8.1	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	456	7	0	5	5.6	COc1ccc(CCN2CCC(=Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1	10.1016/S0960-894X(97)10098-1
	CHEMBL98076	208139	0	None	-1	2	Human	8.1	pIC50	=	8.1	Functional	Antagonistic activity against histamine H1 receptorAntagonistic activity against histamine H1 receptor	ChEMBL	456	7	0	5	5.6	COc1ccc(CCN2CCC(=Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1	10.1016/S0960-894X(97)10098-1
	13623370	98391	0	None	-	1	Guinea pig	8.1	pIC50	=	8.1	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	358	9	0	5	3.8	CCCCCN1CCCN(c2nc3ccccc3n2CCOCC)CC1	10.1021/jm00157a010
	CHEMBL275383	98391	0	None	-	1	Guinea pig	8.1	pIC50	=	8.1	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	358	9	0	5	3.8	CCCCCN1CCCN(c2nc3ccccc3n2CCOCC)CC1	10.1021/jm00157a010
	46224879	201547	3	None	-1	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challenge	ChEMBL	302	2	0	2	4.6	Cc1ccc2c(c1)c1c(n2/C=C\c2ccccc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
	CHEMBL605405	201547	3	None	-1	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challenge	ChEMBL	302	2	0	2	4.6	Cc1ccc2c(c1)c1c(n2/C=C\c2ccccc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
	54581998	62735	3	None	5	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	368	4	0	4	4.3	CN1CCc2c(c3cc(-c4cccnc4)ccc3n2CCc2ccccn2)C1	10.1016/j.bmcl.2009.04.128
	CHEMBL1783972	62735	3	None	5	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	368	4	0	4	4.3	CN1CCc2c(c3cc(-c4cccnc4)ccc3n2CCc2ccccn2)C1	10.1016/j.bmcl.2009.04.128
	54585846	62727	5	None	38	2	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assay	ChEMBL	323	3	0	3	3.7	Cc1ccc(CCn2c3c(c4cc(F)ccc42)CN(C)CC3)cn1	10.1016/j.bmcl.2009.04.128
	CHEMBL1783963	62727	5	None	38	2	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assay	ChEMBL	323	3	0	3	3.7	Cc1ccc(CCn2c3c(c4cc(F)ccc42)CN(C)CC3)cn1	10.1016/j.bmcl.2009.04.128
	54583939	62737	5	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	388	4	0	4	4.0	Cc1ccc2c(c1)c1c(n2CCc2ccncc2)CCN(C2CCN(C)CC2)C1	10.1016/j.bmcl.2009.04.128
	CHEMBL1783975	62737	5	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	388	4	0	4	4.0	Cc1ccc2c(c1)c1c(n2CCc2ccncc2)CCN(C2CCN(C)CC2)C1	10.1016/j.bmcl.2009.04.128
	13623340	59041	0	None	-	1	Guinea pig	6.1	pIC50	=	6.1	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	292	2	0	4	2.8	CN1CCN(c2nc3ccccc3n2-c2ccccc2)CC1	10.1021/jm00157a010
	CHEMBL16938	59041	0	None	-	1	Guinea pig	6.1	pIC50	=	6.1	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	292	2	0	4	2.8	CN1CCN(c2nc3ccccc3n2-c2ccccc2)CC1	10.1021/jm00157a010
	54583938	62733	0	None	1	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assay	ChEMBL	306	3	0	4	3.0	Cc1ccc2c(c1)c1c(n2CCc2cnccn2)CCN(C)C1	10.1016/j.bmcl.2009.04.128
	CHEMBL1783970	62733	0	None	1	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assay	ChEMBL	306	3	0	4	3.0	Cc1ccc2c(c1)c1c(n2CCc2cnccn2)CCN(C)C1	10.1016/j.bmcl.2009.04.128
	13623369	62393	0	None	-	1	Guinea pig	8.1	pIC50	=	8.1	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	344	8	0	5	3.4	CCCCN1CCCN(c2nc3ccccc3n2CCOCC)CC1	10.1021/jm00157a010
	CHEMBL17795	62393	0	None	-	1	Guinea pig	8.1	pIC50	=	8.1	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	344	8	0	5	3.4	CCCCN1CCCN(c2nc3ccccc3n2CCOCC)CC1	10.1021/jm00157a010
	13623368	162246	0	None	-	1	Guinea pig	8.1	pIC50	=	8.1	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	330	7	0	5	3.0	CCCN1CCCN(c2nc3ccccc3n2CCOCC)CC1	10.1021/jm00157a010
	CHEMBL416357	162246	0	None	-	1	Guinea pig	8.1	pIC50	=	8.1	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	330	7	0	5	3.0	CCCN1CCCN(c2nc3ccccc3n2CCOCC)CC1	10.1021/jm00157a010
	13623362	98083	0	None	-	1	Guinea pig	8.1	pIC50	=	8.1	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	358	10	0	5	3.8	CCCCCCN1CCN(c2nc3ccccc3n2CCOCC)CC1	10.1021/jm00157a010
	CHEMBL273315	98083	0	None	-	1	Guinea pig	8.1	pIC50	=	8.1	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	358	10	0	5	3.8	CCCCCCN1CCN(c2nc3ccccc3n2CCOCC)CC1	10.1021/jm00157a010
	16082831	80346	0	None	-1000	3	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human H1 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assayAntagonist activity at human H1 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assay	ChEMBL	275	6	2	2	3.3	Clc1ccc(CNCC[C@H]2C[C@@H]2c2c[nH]cn2)cc1	10.1021/jm0603318
	CHEMBL214311	80346	0	None	-1000	3	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human H1 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assayAntagonist activity at human H1 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene assay	ChEMBL	275	6	2	2	3.3	Clc1ccc(CNCC[C@H]2C[C@@H]2c2c[nH]cn2)cc1	10.1021/jm0603318
	13623353	60498	0	None	-	1	Guinea pig	6.1	pIC50	=	6.1	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	288	5	0	5	1.8	COCCCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	CHEMBL17556	60498	0	None	-	1	Guinea pig	6.1	pIC50	=	6.1	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	288	5	0	5	1.8	COCCCn1c(N2CCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	11976	920	59	None	-9	16	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assayAntagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assay	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1021/jm300671m
	667467	920	59	None	-9	16	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assayAntagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assay	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1021/jm300671m
	CHEMBL908	920	59	None	-9	16	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assayAntagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assay	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1021/jm300671m
	DB01239	920	59	None	-9	16	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assayAntagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assay	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1021/jm300671m
	3071012	163290	1	None	-	1	Guinea pig	8.0	pIC50	=	8.0	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	350	5	0	5	3.3	CN1CCCN(c2nc3ccccc3n2CCOc2ccccc2)CC1	10.1021/jm00157a010
	CHEMBL418731	163290	1	None	-	1	Guinea pig	8.0	pIC50	=	8.0	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	350	5	0	5	3.3	CN1CCCN(c2nc3ccccc3n2CCOc2ccccc2)CC1	10.1021/jm00157a010
	3070998	98981	1	None	-	1	Guinea pig	8.0	pIC50	=	8	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	312	5	0	5	1.8	C#CCOCCn1c(N2CCCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	CHEMBL279875	98981	1	None	-	1	Guinea pig	8.0	pIC50	=	8	Functional	In vitro inhibition of histamine-induced contractions in guinea pig ileumIn vitro inhibition of histamine-induced contractions in guinea pig ileum	ChEMBL	312	5	0	5	1.8	C#CCOCCn1c(N2CCCN(C)CC2)nc2ccccc21	10.1021/jm00157a010
	145963961	164403	0	None	-416	6	Human	6.0	pIC50	=	6.0	Functional	Antagonistic activity at histamine 1 receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at histamine 1 receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	425	8	1	7	3.0	CNC(=O)c1cc(OCCCCN2CCN(c3nsc4ccccc34)CC2)ccn1	10.1016/j.bmcl.2018.01.038
	CHEMBL4213342	164403	0	None	-416	6	Human	6.0	pIC50	=	6.0	Functional	Antagonistic activity at histamine 1 receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at histamine 1 receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	425	8	1	7	3.0	CNC(=O)c1cc(OCCCCN2CCN(c3nsc4ccccc34)CC2)ccn1	10.1016/j.bmcl.2018.01.038
	54586812	62717	5	None	12	2	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assay	ChEMBL	291	3	0	3	3.3	CN1CCc2c(c3ccccc3n2CCc2ccccn2)C1	10.1016/j.bmcl.2009.04.128
	CHEMBL1783953	62717	5	None	12	2	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assay	ChEMBL	291	3	0	3	3.3	CN1CCc2c(c3ccccc3n2CCc2ccccn2)C1	10.1016/j.bmcl.2009.04.128
	54586813	62725	5	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assay	ChEMBL	309	3	0	3	3.4	CN1CCc2c(c3cc(F)ccc3n2CCc2cccnc2)C1	10.1016/j.bmcl.2009.04.128
	CHEMBL1783961	62725	5	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound dosed after histamine addition by Fura-2 based fluorometric assay	ChEMBL	309	3	0	3	3.4	CN1CCc2c(c3cc(F)ccc3n2CCc2cccnc2)C1	10.1016/j.bmcl.2009.04.128
	54579956	62720	5	None	3	2	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	309	3	0	3	3.4	CN1CCc2c(c3cc(F)ccc3n2CCc2ccccn2)C1	10.1016/j.bmcl.2009.04.128
	CHEMBL1783956	62720	5	None	3	2	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assayAntagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1 compound incubated before histamine addition by Fura-2 based fluorometric assay	ChEMBL	309	3	0	3	3.4	CN1CCc2c(c3cc(F)ccc3n2CCc2ccccn2)C1	10.1016/j.bmcl.2009.04.128
	10212645	13289	0	None	-346	2	Human	5.0	pIC50	=	5.0	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	774	16	1	10	7.0	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	CHEMBL1191766	13289	0	None	-346	2	Human	5.0	pIC50	=	5.0	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	774	16	1	10	7.0	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	CHEMBL542908	13289	0	None	-346	2	Human	5.0	pIC50	=	5.0	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	774	16	1	10	7.0	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	4601	206747	35	None	-549	19	Human	4.0	pIC50	=	4.0	Functional	Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assayAntagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assay	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1021/jm300671m
	CHEMBL1201023	206747	35	None	-549	19	Human	4.0	pIC50	=	4.0	Functional	Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assayAntagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assay	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1021/jm300671m
	CHEMBL900	206747	35	None	-549	19	Human	4.0	pIC50	=	4.0	Functional	Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assayAntagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence assay	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1021/jm300671m
	44126327	201653	5	None	41	2	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challenge	ChEMBL	372	3	0	2	5.2	Cc1ccc2c(c1)c1c(n2CCc2ccc(C(F)(F)F)cc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
	CHEMBL606036	201653	5	None	41	2	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challengeAntagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 treated 10 to 15 seconds before histamine challenge	ChEMBL	372	3	0	2	5.2	Cc1ccc2c(c1)c1c(n2CCc2ccc(C(F)(F)F)cc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
	10190842	107224	0	None	-63	2	Human	6.0	pIC50	=	6	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	788	16	0	11	7.1	COC(=O)c1ccccc1OCCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21	10.1016/S0960-894X(97)10097-X
	CHEMBL316705	107224	0	None	-63	2	Human	6.0	pIC50	=	6	Functional	Antagonism of the human histamine H1 receptorAntagonism of the human histamine H1 receptor	ChEMBL	788	16	0	11	7.1	COC(=O)c1ccccc1OCCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21	10.1016/S0960-894X(97)10097-X
	71461781	80469	0	None	-	0	Human	10.4	pKd	=	10.4	Functional	Antagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assayAntagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assay	ChEMBL	409	7	0	4	4.9	CCCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1016/j.bmc.2012.08.032
	CHEMBL2146802	80469	0	None	-	0	Human	10.4	pKd	=	10.4	Functional	Antagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assayAntagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assay	ChEMBL	409	7	0	4	4.9	CCCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1016/j.bmc.2012.08.032
	15254720	61301	0	None	-	0	Human	10.0	pKd	=	10	Functional	Antagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assayAntagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assay	ChEMBL	367	4	0	4	3.7	CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1016/j.bmc.2012.08.032
	CHEMBL1767136	61301	0	None	-	0	Human	10.0	pKd	=	10	Functional	Antagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assayAntagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assay	ChEMBL	367	4	0	4	3.7	CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1016/j.bmc.2012.08.032
	71461782	80473	0	None	-	0	Human	10.0	pKd	=	10	Functional	Antagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assayAntagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assay	ChEMBL	410	7	0	5	4.3	CCCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cnccc2c1=O	10.1016/j.bmc.2012.08.032
	CHEMBL2146806	80473	0	None	-	0	Human	10.0	pKd	=	10	Functional	Antagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assayAntagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assay	ChEMBL	410	7	0	5	4.3	CCCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cnccc2c1=O	10.1016/j.bmc.2012.08.032
	2267	559	71	None	32	14	Human	9.7	pKd	=	9.7	Functional	Antagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assayAntagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmc.2012.08.032
	271	559	71	None	32	14	Human	9.7	pKd	=	9.7	Functional	Antagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assayAntagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmc.2012.08.032
	7121	559	71	None	32	14	Human	9.7	pKd	=	9.7	Functional	Antagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assayAntagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmc.2012.08.032
	CHEMBL639	559	71	None	32	14	Human	9.7	pKd	=	9.7	Functional	Antagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assayAntagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmc.2012.08.032
	DB00972	559	71	None	32	14	Human	9.7	pKd	=	9.7	Functional	Antagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assayAntagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmc.2012.08.032
	2267	559	71	None	32	14	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux at 100 nM preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux at 100 nM preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmcl.2016.11.022
	271	559	71	None	32	14	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux at 100 nM preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux at 100 nM preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmcl.2016.11.022
	7121	559	71	None	32	14	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux at 100 nM preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux at 100 nM preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmcl.2016.11.022
	CHEMBL639	559	71	None	32	14	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux at 100 nM preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux at 100 nM preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmcl.2016.11.022
	DB00972	559	71	None	32	14	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux at 100 nM preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux at 100 nM preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmcl.2016.11.022
	2267	559	71	None	32	14	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmcl.2017.09.020
	271	559	71	None	32	14	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmcl.2017.09.020
	7121	559	71	None	32	14	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmcl.2017.09.020
	CHEMBL639	559	71	None	32	14	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmcl.2017.09.020
	DB00972	559	71	None	32	14	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmcl.2017.09.020
	24824726	161109	1	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1016/j.bmcl.2017.09.020
	CHEMBL4060529	161109	1	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1016/j.bmcl.2017.09.020
	CHEMBL4117079	161109	1	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1016/j.bmcl.2017.09.020
	CHEMBL5282336	161109	1	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1016/j.bmcl.2017.09.020
	CHEMBL5286389	161109	1	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1016/j.bmcl.2017.09.020
	25189511	161118	0	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	461	13	1	5	4.5	CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)CCC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4059750	161118	0	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	461	13	1	5	4.5	CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)CCC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4117137	161118	0	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	461	13	1	5	4.5	CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)CCC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	2267	559	71	None	32	14	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization at 100 nM after 30 mins by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization at 100 nM after 30 mins by FLIPR assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1021/jm1013874
	271	559	71	None	32	14	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization at 100 nM after 30 mins by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization at 100 nM after 30 mins by FLIPR assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1021/jm1013874
	7121	559	71	None	32	14	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization at 100 nM after 30 mins by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization at 100 nM after 30 mins by FLIPR assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1021/jm1013874
	CHEMBL639	559	71	None	32	14	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization at 100 nM after 30 mins by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization at 100 nM after 30 mins by FLIPR assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1021/jm1013874
	DB00972	559	71	None	32	14	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization at 100 nM after 30 mins by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization at 100 nM after 30 mins by FLIPR assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1021/jm1013874
	71452871	80468	0	None	-	0	Human	9.6	pKd	=	9.6	Functional	Antagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assayAntagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assay	ChEMBL	412	7	0	6	3.1	COCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cnccc2c1=O	10.1016/j.bmc.2012.08.032
	CHEMBL2146801	80468	0	None	-	0	Human	9.6	pKd	=	9.6	Functional	Antagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assayAntagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assay	ChEMBL	412	7	0	6	3.1	COCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cnccc2c1=O	10.1016/j.bmc.2012.08.032
	25190195	157912	0	None	-	0	Human	9.6	pKd	=	9.6	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	446	9	0	5	5.0	CCCCc1cc(OC2CCN(CCCS(=O)(=O)C(C)(C)C)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4084325	157912	0	None	-	0	Human	9.6	pKd	=	9.6	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	446	9	0	5	5.0	CCCCc1cc(OC2CCN(CCCS(=O)(=O)C(C)(C)C)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	71458203	80472	0	None	-	0	Human	9.5	pKd	=	9.5	Functional	Antagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assayAntagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assay	ChEMBL	368	4	0	5	3.1	CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cnccc2c1=O	10.1016/j.bmc.2012.08.032
	CHEMBL2146805	80472	0	None	-	0	Human	9.5	pKd	=	9.5	Functional	Antagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assayAntagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assay	ChEMBL	368	4	0	5	3.1	CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cnccc2c1=O	10.1016/j.bmc.2012.08.032
	71451044	80474	0	None	-	0	Human	9.5	pKd	=	9.5	Functional	Antagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assayAntagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assay	ChEMBL	410	7	0	5	4.3	CCCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cccnc2c1=O	10.1016/j.bmc.2012.08.032
	CHEMBL2146807	80474	0	None	-	0	Human	9.5	pKd	=	9.5	Functional	Antagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assayAntagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assay	ChEMBL	410	7	0	5	4.3	CCCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cccnc2c1=O	10.1016/j.bmc.2012.08.032
	71458204	80476	0	None	-	0	Human	9.5	pKd	=	9.5	Functional	Antagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assayAntagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assay	ChEMBL	368	4	0	5	3.1	CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ncccc2c1=O	10.1016/j.bmc.2012.08.032
	CHEMBL2146809	80476	0	None	-	0	Human	9.5	pKd	=	9.5	Functional	Antagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assayAntagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assay	ChEMBL	368	4	0	5	3.1	CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ncccc2c1=O	10.1016/j.bmc.2012.08.032
	1530	2182	50	None	-	25	Guinea pig	9.5	pKd	=	9.5	Functional	H1-antihistamine activity in guinea pig ileumH1-antihistamine activity in guinea pig ileum	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1021/jm00161a022
	3827	2182	50	None	-	25	Guinea pig	9.5	pKd	=	9.5	Functional	H1-antihistamine activity in guinea pig ileumH1-antihistamine activity in guinea pig ileum	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1021/jm00161a022
	7206	2182	50	None	-	25	Guinea pig	9.5	pKd	=	9.5	Functional	H1-antihistamine activity in guinea pig ileumH1-antihistamine activity in guinea pig ileum	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1021/jm00161a022
	CHEMBL534	2182	50	None	-	25	Guinea pig	9.5	pKd	=	9.5	Functional	H1-antihistamine activity in guinea pig ileumH1-antihistamine activity in guinea pig ileum	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1021/jm00161a022
	DB00920	2182	50	None	-	25	Guinea pig	9.5	pKd	=	9.5	Functional	H1-antihistamine activity in guinea pig ileumH1-antihistamine activity in guinea pig ileum	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1021/jm00161a022
	1530	2182	50	None	-	25	Guinea pig	9.5	pKd	=	9.5	Functional	H1-antihistamine activity on guinea pig ileumH1-antihistamine activity on guinea pig ileum	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1021/jm00377a013
	3827	2182	50	None	-	25	Guinea pig	9.5	pKd	=	9.5	Functional	H1-antihistamine activity on guinea pig ileumH1-antihistamine activity on guinea pig ileum	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1021/jm00377a013
	7206	2182	50	None	-	25	Guinea pig	9.5	pKd	=	9.5	Functional	H1-antihistamine activity on guinea pig ileumH1-antihistamine activity on guinea pig ileum	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1021/jm00377a013
	CHEMBL534	2182	50	None	-	25	Guinea pig	9.5	pKd	=	9.5	Functional	H1-antihistamine activity on guinea pig ileumH1-antihistamine activity on guinea pig ileum	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1021/jm00377a013
	DB00920	2182	50	None	-	25	Guinea pig	9.5	pKd	=	9.5	Functional	H1-antihistamine activity on guinea pig ileumH1-antihistamine activity on guinea pig ileum	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1021/jm00377a013
	25190192	160995	0	None	-	0	Human	9.5	pKd	=	9.5	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	418	10	0	5	4.2	CCCCc1cc(OC2CCN(CCCS(=O)(=O)CC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4098917	160995	0	None	-	0	Human	9.5	pKd	=	9.5	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	418	10	0	5	4.2	CCCCc1cc(OC2CCN(CCCS(=O)(=O)CC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4116155	160995	0	None	-	0	Human	9.5	pKd	=	9.5	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	418	10	0	5	4.2	CCCCc1cc(OC2CCN(CCCS(=O)(=O)CC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	1227	2489	43	None	-2	14	Guinea pig	9.4	pKd	=	9.4	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/s0960-894x(03)00113-6
	2331	2489	43	None	-2	14	Guinea pig	9.4	pKd	=	9.4	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/s0960-894x(03)00113-6
	3957	2489	43	None	-2	14	Guinea pig	9.4	pKd	=	9.4	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/s0960-894x(03)00113-6
	4992	2489	43	None	-2	14	Guinea pig	9.4	pKd	=	9.4	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/s0960-894x(03)00113-6
	CHEMBL511	2489	43	None	-2	14	Guinea pig	9.4	pKd	=	9.4	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/s0960-894x(03)00113-6
	DB06691	2489	43	None	-2	14	Guinea pig	9.4	pKd	=	9.4	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/s0960-894x(03)00113-6
	25190372	160975	0	None	-	0	Human	9.4	pKd	=	9.4	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	433	11	1	5	3.8	CCCCc1cc(OC2CCN(CCCCNS(C)(=O)=O)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4098192	160975	0	None	-	0	Human	9.4	pKd	=	9.4	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	433	11	1	5	3.8	CCCCc1cc(OC2CCN(CCCCNS(C)(=O)=O)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4115992	160975	0	None	-	0	Human	9.4	pKd	=	9.4	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	433	11	1	5	3.8	CCCCc1cc(OC2CCN(CCCCNS(C)(=O)=O)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	25190194	161162	0	None	-	0	Human	9.4	pKd	=	9.4	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	432	10	0	5	4.6	CCCCc1cc(OC2CCN(CCCS(=O)(=O)C(C)C)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4102287	161162	0	None	-	0	Human	9.4	pKd	=	9.4	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	432	10	0	5	4.6	CCCCc1cc(OC2CCN(CCCS(=O)(=O)C(C)C)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4117432	161162	0	None	-	0	Human	9.4	pKd	=	9.4	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	432	10	0	5	4.6	CCCCc1cc(OC2CCN(CCCS(=O)(=O)C(C)C)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	71452872	80434	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assayAntagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assay	ChEMBL	368	4	0	5	3.1	CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cccnc2c1=O	10.1016/j.bmc.2012.08.032
	CHEMBL2146484	80434	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assayAntagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assay	ChEMBL	368	4	0	5	3.1	CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cccnc2c1=O	10.1016/j.bmc.2012.08.032
	25164129	161160	0	None	-	1	Human	9.3	pKd	=	9.3	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	447	12	1	5	4.1	CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)CC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4088036	161160	0	None	-	1	Human	9.3	pKd	=	9.3	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	447	12	1	5	4.1	CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)CC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4117406	161160	0	None	-	1	Human	9.3	pKd	=	9.3	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	447	12	1	5	4.1	CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)CC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	25189509	161072	0	None	-	0	Human	9.2	pKd	=	9.2	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	461	10	1	5	4.5	CCCCc1cc(OC2CCN(CCCS(=O)(=O)NC(C)(C)C)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4069073	161072	0	None	-	0	Human	9.2	pKd	=	9.2	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	461	10	1	5	4.5	CCCCc1cc(OC2CCN(CCCS(=O)(=O)NC(C)(C)C)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4116734	161072	0	None	-	0	Human	9.2	pKd	=	9.2	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	461	10	1	5	4.5	CCCCc1cc(OC2CCN(CCCS(=O)(=O)NC(C)(C)C)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	44320707	106030	0	None	-	0	Guinea pig	9.2	pKd	=	9.2	Functional	Contractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileumContractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileum	ChEMBL	293	4	1	2	2.9	CN(C)CCc1c[nH]c(-c2cccc(Br)c2)n1	10.1016/s0960-894x(98)00461-2
	CHEMBL313301	106030	0	None	-	0	Guinea pig	9.2	pKd	=	9.2	Functional	Contractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileumContractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileum	ChEMBL	293	4	1	2	2.9	CN(C)CCc1c[nH]c(-c2cccc(Br)c2)n1	10.1016/s0960-894x(98)00461-2
	10403687	2511	3	None	1	2	Guinea pig	9.1	pKd	=	9.1	Functional	Antagonism of guinea pig ileum contraction at 100 nM mepyramineAntagonism of guinea pig ileum contraction at 100 nM mepyramine	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	1205	2511	3	None	1	2	Guinea pig	9.1	pKd	=	9.1	Functional	Antagonism of guinea pig ileum contraction at 100 nM mepyramineAntagonism of guinea pig ileum contraction at 100 nM mepyramine	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	CHEMBL275035	2511	3	None	1	2	Guinea pig	9.1	pKd	=	9.1	Functional	Antagonism of guinea pig ileum contraction at 100 nM mepyramineAntagonism of guinea pig ileum contraction at 100 nM mepyramine	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	25190193	161199	0	None	-	0	Human	9.1	pKd	=	9.1	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	432	11	0	5	4.6	CCCCc1cc(OC2CCN(CCCS(=O)(=O)CCC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4080880	161199	0	None	-	0	Human	9.1	pKd	=	9.1	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	432	11	0	5	4.6	CCCCc1cc(OC2CCN(CCCS(=O)(=O)CCC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4117740	161199	0	None	-	0	Human	9.1	pKd	=	9.1	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	432	11	0	5	4.6	CCCCc1cc(OC2CCN(CCCS(=O)(=O)CCC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	1194	45	3	None	-	2	Guinea pig	9.1	pKd	=	9.1	Functional	Contractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileumContractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileum	ChEMBL	265	3	2	2	2.3	NCCc1cnc([nH]1)c1cccc(c1)Br	10.1016/s0960-894x(98)00461-2
	23786499	45	3	None	-	2	Guinea pig	9.1	pKd	=	9.1	Functional	Contractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileumContractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileum	ChEMBL	265	3	2	2	2.3	NCCc1cnc([nH]1)c1cccc(c1)Br	10.1016/s0960-894x(98)00461-2
	CHEMBL26116	45	3	None	-	2	Guinea pig	9.1	pKd	=	9.1	Functional	Contractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileumContractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileum	ChEMBL	265	3	2	2	2.3	NCCc1cnc([nH]1)c1cccc(c1)Br	10.1016/s0960-894x(98)00461-2
	44320708	206377	0	None	-	0	Guinea pig	9.1	pKd	=	9.1	Functional	Contractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileumContractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileum	ChEMBL	295	5	2	2	3.4	FC(F)(F)c1cccc(-c2nc(CCNC3CC3)c[nH]2)c1	10.1016/s0960-894x(98)00461-2
	CHEMBL87583	206377	0	None	-	0	Guinea pig	9.1	pKd	=	9.1	Functional	Contractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileumContractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileum	ChEMBL	295	5	2	2	3.4	FC(F)(F)c1cccc(-c2nc(CCNC3CC3)c[nH]2)c1	10.1016/s0960-894x(98)00461-2
	44320686	206453	1	None	-	0	Guinea pig	9.1	pKd	=	9.1	Functional	Contractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileumContractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileum	ChEMBL	279	4	2	2	2.6	CNCCc1c[nH]c(-c2cccc(Br)c2)n1	10.1016/s0960-894x(98)00461-2
	CHEMBL88075	206453	1	None	-	0	Guinea pig	9.1	pKd	=	9.1	Functional	Contractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileumContractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileum	ChEMBL	279	4	2	2	2.6	CNCCc1c[nH]c(-c2cccc(Br)c2)n1	10.1016/s0960-894x(98)00461-2
	10042467	1426	1	None	-1	2	Guinea pig	9.1	pKd	=	9.1	Functional	Antagonism of guinea pig ileum contraction at 100 nM mepyramineAntagonism of guinea pig ileum contraction at 100 nM mepyramine	ChEMBL	333	8	1	2	4.3	CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C	10.1021/jm991056a
	1203	1426	1	None	-1	2	Guinea pig	9.1	pKd	=	9.1	Functional	Antagonism of guinea pig ileum contraction at 100 nM mepyramineAntagonism of guinea pig ileum contraction at 100 nM mepyramine	ChEMBL	333	8	1	2	4.3	CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C	10.1021/jm991056a
	CHEMBL11553	1426	1	None	-1	2	Guinea pig	9.1	pKd	=	9.1	Functional	Antagonism of guinea pig ileum contraction at 100 nM mepyramineAntagonism of guinea pig ileum contraction at 100 nM mepyramine	ChEMBL	333	8	1	2	4.3	CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C	10.1021/jm991056a
	10447834	1933	4	None	2	3	Guinea pig	9.1	pKd	=	9.1	Functional	Antagonism of guinea pig ileum contraction at 100 nM mepyramineAntagonism of guinea pig ileum contraction at 100 nM mepyramine	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	4026	1933	4	None	2	3	Guinea pig	9.1	pKd	=	9.1	Functional	Antagonism of guinea pig ileum contraction at 100 nM mepyramineAntagonism of guinea pig ileum contraction at 100 nM mepyramine	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	CHEMBL275507	1933	4	None	2	3	Guinea pig	9.1	pKd	=	9.1	Functional	Antagonism of guinea pig ileum contraction at 100 nM mepyramineAntagonism of guinea pig ileum contraction at 100 nM mepyramine	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	1204	1932	119	None	-3	10	Guinea pig	9.1	pKd	=	9.1	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig ileum (contraction) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig ileum (contraction) at a mepyramine concentration of 100 nM	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm991056a
	1247	1932	119	None	-3	10	Guinea pig	9.1	pKd	=	9.1	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig ileum (contraction) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig ileum (contraction) at a mepyramine concentration of 100 nM	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm991056a
	1375	1932	119	None	-3	10	Guinea pig	9.1	pKd	=	9.1	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig ileum (contraction) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig ileum (contraction) at a mepyramine concentration of 100 nM	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm991056a
	774	1932	119	None	-3	10	Guinea pig	9.1	pKd	=	9.1	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig ileum (contraction) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig ileum (contraction) at a mepyramine concentration of 100 nM	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm991056a
	CHEMBL90	1932	119	None	-3	10	Guinea pig	9.1	pKd	=	9.1	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig ileum (contraction) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig ileum (contraction) at a mepyramine concentration of 100 nM	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm991056a
	DB05381	1932	119	None	-3	10	Guinea pig	9.1	pKd	=	9.1	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig ileum (contraction) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig ileum (contraction) at a mepyramine concentration of 100 nM	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm991056a
	1204	1932	119	None	-3	10	Guinea pig	9.1	pKd	=	9.1	Functional	Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/s0960-894x(98)00461-2
	1247	1932	119	None	-3	10	Guinea pig	9.1	pKd	=	9.1	Functional	Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/s0960-894x(98)00461-2
	1375	1932	119	None	-3	10	Guinea pig	9.1	pKd	=	9.1	Functional	Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/s0960-894x(98)00461-2
	774	1932	119	None	-3	10	Guinea pig	9.1	pKd	=	9.1	Functional	Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/s0960-894x(98)00461-2
	CHEMBL90	1932	119	None	-3	10	Guinea pig	9.1	pKd	=	9.1	Functional	Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/s0960-894x(98)00461-2
	DB05381	1932	119	None	-3	10	Guinea pig	9.1	pKd	=	9.1	Functional	Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/s0960-894x(98)00461-2
	17747460	61329	12	None	-	2	Human	9.1	pKd	=	9.1	Functional	Antagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assayAntagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assay	ChEMBL	640	14	0	6	7.8	O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1	10.1016/j.bmc.2012.08.032
	CHEMBL1767164	61329	12	None	-	2	Human	9.1	pKd	=	9.1	Functional	Antagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assayAntagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assay	ChEMBL	640	14	0	6	7.8	O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1	10.1016/j.bmc.2012.08.032
	71456360	80475	0	None	-	0	Human	9.1	pKd	=	9.1	Functional	Antagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assayAntagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assay	ChEMBL	412	7	0	6	3.1	COCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cccnc2c1=O	10.1016/j.bmc.2012.08.032
	CHEMBL2146808	80475	0	None	-	0	Human	9.1	pKd	=	9.1	Functional	Antagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assayAntagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assay	ChEMBL	412	7	0	6	3.1	COCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cccnc2c1=O	10.1016/j.bmc.2012.08.032
	17747460	61329	12	None	-	2	Human	9.1	pKd	=	9.1	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux at 100 nM preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux at 100 nM preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	640	14	0	6	7.8	O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1	10.1016/j.bmcl.2016.11.022
	CHEMBL1767164	61329	12	None	-	2	Human	9.1	pKd	=	9.1	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux at 100 nM preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux at 100 nM preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	640	14	0	6	7.8	O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1	10.1016/j.bmcl.2016.11.022
	17747460	61329	12	None	-	2	Human	9.1	pKd	=	9.1	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization at 100 nM after 30 mins by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization at 100 nM after 30 mins by FLIPR assay	ChEMBL	640	14	0	6	7.8	O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1	10.1021/jm1013874
	CHEMBL1767164	61329	12	None	-	2	Human	9.1	pKd	=	9.1	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization at 100 nM after 30 mins by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization at 100 nM after 30 mins by FLIPR assay	ChEMBL	640	14	0	6	7.8	O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1	10.1021/jm1013874
	1227	2489	43	None	-2	14	Guinea pig	9.1	pKd	=	9.1	Functional	H1-antihistamine activity in guinea pig ileumH1-antihistamine activity in guinea pig ileum	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm00161a022
	2331	2489	43	None	-2	14	Guinea pig	9.1	pKd	=	9.1	Functional	H1-antihistamine activity in guinea pig ileumH1-antihistamine activity in guinea pig ileum	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm00161a022
	3957	2489	43	None	-2	14	Guinea pig	9.1	pKd	=	9.1	Functional	H1-antihistamine activity in guinea pig ileumH1-antihistamine activity in guinea pig ileum	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm00161a022
	4992	2489	43	None	-2	14	Guinea pig	9.1	pKd	=	9.1	Functional	H1-antihistamine activity in guinea pig ileumH1-antihistamine activity in guinea pig ileum	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm00161a022
	CHEMBL511	2489	43	None	-2	14	Guinea pig	9.1	pKd	=	9.1	Functional	H1-antihistamine activity in guinea pig ileumH1-antihistamine activity in guinea pig ileum	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm00161a022
	DB06691	2489	43	None	-2	14	Guinea pig	9.1	pKd	=	9.1	Functional	H1-antihistamine activity in guinea pig ileumH1-antihistamine activity in guinea pig ileum	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm00161a022
	13676700	204784	0	None	-	0	Guinea pig	9.1	pKd	=	9.1	Functional	H1-antihistamine activity in guinea pig ileumH1-antihistamine activity in guinea pig ileum	ChEMBL	453	7	1	8	3.7	Oc1c2nnnc-2oc2cc(OCCCN3CCN(Cc4ccc(Cl)cc4)CC3)ccc12	10.1021/jm00161a022
	CHEMBL74870	204784	0	None	-	0	Guinea pig	9.1	pKd	=	9.1	Functional	H1-antihistamine activity in guinea pig ileumH1-antihistamine activity in guinea pig ileum	ChEMBL	453	7	1	8	3.7	Oc1c2nnnc-2oc2cc(OCCCN3CCN(Cc4ccc(Cl)cc4)CC3)ccc12	10.1021/jm00161a022
	1227	2489	43	None	-2	14	Guinea pig	9.1	pKd	=	9.1	Functional	H1-antihistamine activity on guinea pig ileumH1-antihistamine activity on guinea pig ileum	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm00377a013
	2331	2489	43	None	-2	14	Guinea pig	9.1	pKd	=	9.1	Functional	H1-antihistamine activity on guinea pig ileumH1-antihistamine activity on guinea pig ileum	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm00377a013
	3957	2489	43	None	-2	14	Guinea pig	9.1	pKd	=	9.1	Functional	H1-antihistamine activity on guinea pig ileumH1-antihistamine activity on guinea pig ileum	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm00377a013
	4992	2489	43	None	-2	14	Guinea pig	9.1	pKd	=	9.1	Functional	H1-antihistamine activity on guinea pig ileumH1-antihistamine activity on guinea pig ileum	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm00377a013
	CHEMBL511	2489	43	None	-2	14	Guinea pig	9.1	pKd	=	9.1	Functional	H1-antihistamine activity on guinea pig ileumH1-antihistamine activity on guinea pig ileum	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm00377a013
	DB06691	2489	43	None	-2	14	Guinea pig	9.1	pKd	=	9.1	Functional	H1-antihistamine activity on guinea pig ileumH1-antihistamine activity on guinea pig ileum	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm00377a013
	25190374	161178	0	None	-	0	Human	9.1	pKd	=	9.1	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	475	13	1	5	4.8	CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)CC(C)C)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4082646	161178	0	None	-	0	Human	9.1	pKd	=	9.1	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	475	13	1	5	4.8	CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)CC(C)C)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4117608	161178	0	None	-	0	Human	9.1	pKd	=	9.1	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	475	13	1	5	4.8	CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)CC(C)C)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	9993212	206207	1	None	-	0	Guinea pig	9.1	pKd	=	9.1	Functional	Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.	ChEMBL	269	4	2	2	2.9	CNCCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1	10.1016/s0960-894x(98)00461-2
	CHEMBL86522	206207	1	None	-	0	Guinea pig	9.1	pKd	=	9.1	Functional	Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.	ChEMBL	269	4	2	2	2.9	CNCCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1	10.1016/s0960-894x(98)00461-2
	1227	2489	43	None	-2	14	Guinea pig	9.1	pKd	=	9.1	Functional	Antagonism against H1 histamine receptor of guinea pig ileumAntagonism against H1 histamine receptor of guinea pig ileum	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/0960-894X(95)00092-8
	2331	2489	43	None	-2	14	Guinea pig	9.1	pKd	=	9.1	Functional	Antagonism against H1 histamine receptor of guinea pig ileumAntagonism against H1 histamine receptor of guinea pig ileum	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/0960-894X(95)00092-8
	3957	2489	43	None	-2	14	Guinea pig	9.1	pKd	=	9.1	Functional	Antagonism against H1 histamine receptor of guinea pig ileumAntagonism against H1 histamine receptor of guinea pig ileum	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/0960-894X(95)00092-8
	4992	2489	43	None	-2	14	Guinea pig	9.1	pKd	=	9.1	Functional	Antagonism against H1 histamine receptor of guinea pig ileumAntagonism against H1 histamine receptor of guinea pig ileum	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/0960-894X(95)00092-8
	CHEMBL511	2489	43	None	-2	14	Guinea pig	9.1	pKd	=	9.1	Functional	Antagonism against H1 histamine receptor of guinea pig ileumAntagonism against H1 histamine receptor of guinea pig ileum	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/0960-894X(95)00092-8
	DB06691	2489	43	None	-2	14	Guinea pig	9.1	pKd	=	9.1	Functional	Antagonism against H1 histamine receptor of guinea pig ileumAntagonism against H1 histamine receptor of guinea pig ileum	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/0960-894X(95)00092-8
	1227	2489	43	None	-2	14	Guinea pig	9.1	pKd	=	9.1	Functional	Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsAntagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmcl.2011.09.001
	2331	2489	43	None	-2	14	Guinea pig	9.1	pKd	=	9.1	Functional	Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsAntagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmcl.2011.09.001
	3957	2489	43	None	-2	14	Guinea pig	9.1	pKd	=	9.1	Functional	Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsAntagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmcl.2011.09.001
	4992	2489	43	None	-2	14	Guinea pig	9.1	pKd	=	9.1	Functional	Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsAntagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmcl.2011.09.001
	CHEMBL511	2489	43	None	-2	14	Guinea pig	9.1	pKd	=	9.1	Functional	Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsAntagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmcl.2011.09.001
	DB06691	2489	43	None	-2	14	Guinea pig	9.1	pKd	=	9.1	Functional	Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsAntagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmcl.2011.09.001
	1204	1932	119	None	-3	10	Guinea pig	9.1	pKd	=	9.1	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig ileum (contraction) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig ileum (contraction) at a mepyramine concentration of 100 nM	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm991056a
	1247	1932	119	None	-3	10	Guinea pig	9.1	pKd	=	9.1	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig ileum (contraction) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig ileum (contraction) at a mepyramine concentration of 100 nM	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm991056a
	1375	1932	119	None	-3	10	Guinea pig	9.1	pKd	=	9.1	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig ileum (contraction) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig ileum (contraction) at a mepyramine concentration of 100 nM	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm991056a
	774	1932	119	None	-3	10	Guinea pig	9.1	pKd	=	9.1	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig ileum (contraction) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig ileum (contraction) at a mepyramine concentration of 100 nM	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm991056a
	CHEMBL90	1932	119	None	-3	10	Guinea pig	9.1	pKd	=	9.1	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig ileum (contraction) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig ileum (contraction) at a mepyramine concentration of 100 nM	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm991056a
	DB05381	1932	119	None	-3	10	Guinea pig	9.1	pKd	=	9.1	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig ileum (contraction) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig ileum (contraction) at a mepyramine concentration of 100 nM	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm991056a
	1204	1932	119	None	-3	10	Guinea pig	9.1	pKd	=	9.1	Functional	Contractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileumContractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileum	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/s0960-894x(98)00461-2
	1247	1932	119	None	-3	10	Guinea pig	9.1	pKd	=	9.1	Functional	Contractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileumContractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileum	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/s0960-894x(98)00461-2
	1375	1932	119	None	-3	10	Guinea pig	9.1	pKd	=	9.1	Functional	Contractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileumContractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileum	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/s0960-894x(98)00461-2
	774	1932	119	None	-3	10	Guinea pig	9.1	pKd	=	9.1	Functional	Contractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileumContractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileum	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/s0960-894x(98)00461-2
	CHEMBL90	1932	119	None	-3	10	Guinea pig	9.1	pKd	=	9.1	Functional	Contractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileumContractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileum	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/s0960-894x(98)00461-2
	DB05381	1932	119	None	-3	10	Guinea pig	9.1	pKd	=	9.1	Functional	Contractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileumContractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileum	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/s0960-894x(98)00461-2
	5310982	93612	4	None	-	2	Guinea pig	9.1	pKd	=	9.1	Functional	Contractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileumContractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileum	ChEMBL	255	3	2	2	2.6	NCCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1	10.1016/s0960-894x(98)00461-2
	CHEMBL24665	93612	4	None	-	2	Guinea pig	9.1	pKd	=	9.1	Functional	Contractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileumContractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileum	ChEMBL	255	3	2	2	2.6	NCCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1	10.1016/s0960-894x(98)00461-2
	9993212	206207	1	None	-	0	Guinea pig	9.0	pKd	=	9.0	Functional	Contractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileumContractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileum	ChEMBL	269	4	2	2	2.9	CNCCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1	10.1016/s0960-894x(98)00461-2
	CHEMBL86522	206207	1	None	-	0	Guinea pig	9.0	pKd	=	9.0	Functional	Contractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileumContractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileum	ChEMBL	269	4	2	2	2.9	CNCCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1	10.1016/s0960-894x(98)00461-2
	10689833	12766	0	None	4	2	Guinea pig	9.0	pKd	=	9.0	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig ileum (contraction) at a mepyramine concentration of 100 nM; value ranges from 9.02 to 9.42Compound was evaluated for mepyramine antagonism effects in guinea pig ileum (contraction) at a mepyramine concentration of 100 nM; value ranges from 9.02 to 9.42	ChEMBL	359	8	1	2	4.8	c1ccc(C(CCc2nc(CCN3CCCC3)c[nH]2)c2ccccc2)cc1	10.1021/jm991056a
	CHEMBL11879	12766	0	None	4	2	Guinea pig	9.0	pKd	=	9.0	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig ileum (contraction) at a mepyramine concentration of 100 nM; value ranges from 9.02 to 9.42Compound was evaluated for mepyramine antagonism effects in guinea pig ileum (contraction) at a mepyramine concentration of 100 nM; value ranges from 9.02 to 9.42	ChEMBL	359	8	1	2	4.8	c1ccc(C(CCc2nc(CCN3CCCC3)c[nH]2)c2ccccc2)cc1	10.1021/jm991056a
	10447834	1933	4	None	2	3	Guinea pig	9.0	pKd	=	9.0	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nM	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	4026	1933	4	None	2	3	Guinea pig	9.0	pKd	=	9.0	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nM	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	CHEMBL275507	1933	4	None	2	3	Guinea pig	9.0	pKd	=	9.0	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nM	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	5310982	93612	4	None	-	2	Guinea pig	9.0	pKd	=	9.0	Functional	Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.	ChEMBL	255	3	2	2	2.6	NCCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1	10.1016/s0960-894x(98)00461-2
	CHEMBL24665	93612	4	None	-	2	Guinea pig	9.0	pKd	=	9.0	Functional	Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.	ChEMBL	255	3	2	2	2.6	NCCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1	10.1016/s0960-894x(98)00461-2
	44320686	206453	1	None	-	0	Guinea pig	9.0	pKd	=	9.0	Functional	Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.	ChEMBL	279	4	2	2	2.6	CNCCc1c[nH]c(-c2cccc(Br)c2)n1	10.1016/s0960-894x(98)00461-2
	CHEMBL88075	206453	1	None	-	0	Guinea pig	9.0	pKd	=	9.0	Functional	Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.	ChEMBL	279	4	2	2	2.6	CNCCc1c[nH]c(-c2cccc(Br)c2)n1	10.1016/s0960-894x(98)00461-2
	24804150	80480	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assayAntagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assay	ChEMBL	641	14	0	7	7.2	O=c1c2ccncc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1	10.1016/j.bmc.2012.08.032
	CHEMBL2146813	80480	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assayAntagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assay	ChEMBL	641	14	0	7	7.2	O=c1c2ccncc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1	10.1016/j.bmc.2012.08.032
	25189510	156109	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	461	13	1	5	4.5	CCCCc1cc(OC2CCN(CCCCS(=O)(=O)NCCC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4063163	156109	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	461	13	1	5	4.5	CCCCc1cc(OC2CCN(CCCCS(=O)(=O)NCCC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	25190375	161084	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	501	12	1	5	5.5	CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)C3CCCCC3)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4088039	161084	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	501	12	1	5	5.5	CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)C3CCCCC3)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4116791	161084	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	501	12	1	5	5.5	CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)C3CCCCC3)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	25190431	161213	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	461	12	0	5	4.5	CCCCc1cc(OC2CCN(CCCCN(C)S(=O)(=O)CC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4065123	161213	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	461	12	0	5	4.5	CCCCc1cc(OC2CCN(CCCCN(C)S(=O)(=O)CC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4117871	161213	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	461	12	0	5	4.5	CCCCc1cc(OC2CCN(CCCCN(C)S(=O)(=O)CC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	1204	1932	119	None	-3	10	Guinea pig	9.0	pKd	=	9	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nM	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm991056a
	1247	1932	119	None	-3	10	Guinea pig	9.0	pKd	=	9	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nM	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm991056a
	1375	1932	119	None	-3	10	Guinea pig	9.0	pKd	=	9	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nM	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm991056a
	774	1932	119	None	-3	10	Guinea pig	9.0	pKd	=	9	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nM	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm991056a
	CHEMBL90	1932	119	None	-3	10	Guinea pig	9.0	pKd	=	9	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nM	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm991056a
	DB05381	1932	119	None	-3	10	Guinea pig	9.0	pKd	=	9	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nM	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm991056a
	54710796	120423	0	None	-	0	Guinea pig	9.0	pKd	=	9	Functional	H1-antihistamine activity on guinea pig ileumH1-antihistamine activity on guinea pig ileum	ChEMBL	473	8	1	8	3.6	O=c1oc2cc(OCCCN3CCN(Cc4ccc(Cl)cc4)CC3)ccc2c(O)c1[N+](=O)[O-]	10.1021/jm00377a013
	CHEMBL35376	120423	0	None	-	0	Guinea pig	9.0	pKd	=	9	Functional	H1-antihistamine activity on guinea pig ileumH1-antihistamine activity on guinea pig ileum	ChEMBL	473	8	1	8	3.6	O=c1oc2cc(OCCCN3CCN(Cc4ccc(Cl)cc4)CC3)ccc2c(O)c1[N+](=O)[O-]	10.1021/jm00377a013
	1227	2489	43	None	-2	14	Guinea pig	9.0	pKd	=	9	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm00093a025
	2331	2489	43	None	-2	14	Guinea pig	9.0	pKd	=	9	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm00093a025
	3957	2489	43	None	-2	14	Guinea pig	9.0	pKd	=	9	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm00093a025
	4992	2489	43	None	-2	14	Guinea pig	9.0	pKd	=	9	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm00093a025
	CHEMBL511	2489	43	None	-2	14	Guinea pig	9.0	pKd	=	9	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm00093a025
	DB06691	2489	43	None	-2	14	Guinea pig	9.0	pKd	=	9	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm00093a025
	1204	1932	119	None	-3	10	Guinea pig	9.0	pKd	=	9	Functional	Relative potency against Histamine H1 receptor in endothelium-Denuded rings of guinea pig AortaRelative potency against Histamine H1 receptor in endothelium-Denuded rings of guinea pig Aorta	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0309147
	1247	1932	119	None	-3	10	Guinea pig	9.0	pKd	=	9	Functional	Relative potency against Histamine H1 receptor in endothelium-Denuded rings of guinea pig AortaRelative potency against Histamine H1 receptor in endothelium-Denuded rings of guinea pig Aorta	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0309147
	1375	1932	119	None	-3	10	Guinea pig	9.0	pKd	=	9	Functional	Relative potency against Histamine H1 receptor in endothelium-Denuded rings of guinea pig AortaRelative potency against Histamine H1 receptor in endothelium-Denuded rings of guinea pig Aorta	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0309147
	774	1932	119	None	-3	10	Guinea pig	9.0	pKd	=	9	Functional	Relative potency against Histamine H1 receptor in endothelium-Denuded rings of guinea pig AortaRelative potency against Histamine H1 receptor in endothelium-Denuded rings of guinea pig Aorta	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0309147
	CHEMBL90	1932	119	None	-3	10	Guinea pig	9.0	pKd	=	9	Functional	Relative potency against Histamine H1 receptor in endothelium-Denuded rings of guinea pig AortaRelative potency against Histamine H1 receptor in endothelium-Denuded rings of guinea pig Aorta	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0309147
	DB05381	1932	119	None	-3	10	Guinea pig	9.0	pKd	=	9	Functional	Relative potency against Histamine H1 receptor in endothelium-Denuded rings of guinea pig AortaRelative potency against Histamine H1 receptor in endothelium-Denuded rings of guinea pig Aorta	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0309147
	44320685	206452	0	None	-	0	Guinea pig	9.0	pKd	=	9.0	Functional	Contractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileumContractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileum	ChEMBL	283	5	2	2	3.2	CCNCCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1	10.1016/s0960-894x(98)00461-2
	CHEMBL88074	206452	0	None	-	0	Guinea pig	9.0	pKd	=	9.0	Functional	Contractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileumContractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileum	ChEMBL	283	5	2	2	3.2	CCNCCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1	10.1016/s0960-894x(98)00461-2
	1227	2489	43	None	-2	14	Guinea pig	9.0	pKd	=	9.0	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as histamine-induced contractions	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.ejmech.2008.09.019
	2331	2489	43	None	-2	14	Guinea pig	9.0	pKd	=	9.0	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as histamine-induced contractions	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.ejmech.2008.09.019
	3957	2489	43	None	-2	14	Guinea pig	9.0	pKd	=	9.0	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as histamine-induced contractions	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.ejmech.2008.09.019
	4992	2489	43	None	-2	14	Guinea pig	9.0	pKd	=	9.0	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as histamine-induced contractions	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.ejmech.2008.09.019
	CHEMBL511	2489	43	None	-2	14	Guinea pig	9.0	pKd	=	9.0	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as histamine-induced contractions	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.ejmech.2008.09.019
	DB06691	2489	43	None	-2	14	Guinea pig	9.0	pKd	=	9.0	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as histamine-induced contractions	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.ejmech.2008.09.019
	44320707	106030	0	None	-	0	Guinea pig	8.9	pKd	=	8.9	Functional	Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.	ChEMBL	293	4	1	2	2.9	CN(C)CCc1c[nH]c(-c2cccc(Br)c2)n1	10.1016/s0960-894x(98)00461-2
	CHEMBL313301	106030	0	None	-	0	Guinea pig	8.9	pKd	=	8.9	Functional	Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.	ChEMBL	293	4	1	2	2.9	CN(C)CCc1c[nH]c(-c2cccc(Br)c2)n1	10.1016/s0960-894x(98)00461-2
	10407870	106761	0	None	-	0	Guinea pig	8.9	pKd	=	8.9	Functional	Contractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileumContractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileum	ChEMBL	283	4	1	2	3.2	CN(C)CCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1	10.1016/s0960-894x(98)00461-2
	CHEMBL314438	106761	0	None	-	0	Guinea pig	8.9	pKd	=	8.9	Functional	Contractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileumContractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileum	ChEMBL	283	4	1	2	3.2	CN(C)CCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1	10.1016/s0960-894x(98)00461-2
	25190317	161058	0	None	-	0	Human	8.9	pKd	=	8.9	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	433	11	1	5	3.8	CCCCc1cc(OC2CCN(CCCNS(=O)(=O)CC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4080166	161058	0	None	-	0	Human	8.9	pKd	=	8.9	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	433	11	1	5	3.8	CCCCc1cc(OC2CCN(CCCNS(=O)(=O)CC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4116610	161058	0	None	-	0	Human	8.9	pKd	=	8.9	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	433	11	1	5	3.8	CCCCc1cc(OC2CCN(CCCNS(=O)(=O)CC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	24803638	61330	0	None	-	0	Human	8.9	pKd	=	8.9	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization at 100 nM after 30 mins by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization at 100 nM after 30 mins by FLIPR assay	ChEMBL	636	15	0	7	7.1	COc1ccc(Cc2nn(C[C@H]3CCCN3CCCCc3ccc(OCCCN4CCCCCC4)cc3)c(=O)c3ccccc23)cc1	10.1021/jm1013874
	CHEMBL1767165	61330	0	None	-	0	Human	8.9	pKd	=	8.9	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization at 100 nM after 30 mins by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization at 100 nM after 30 mins by FLIPR assay	ChEMBL	636	15	0	7	7.1	COc1ccc(Cc2nn(C[C@H]3CCCN3CCCCc3ccc(OCCCN4CCCCCC4)cc3)c(=O)c3ccccc23)cc1	10.1021/jm1013874
	24803483	61332	0	None	-	0	Human	8.9	pKd	=	8.9	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization at 100 nM after 30 mins by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization at 100 nM after 30 mins by FLIPR assay	ChEMBL	654	15	0	6	8.2	O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCCc1ccc(OCCCN2CCCCCC2)cc1	10.1021/jm1013874
	CHEMBL1767167	61332	0	None	-	0	Human	8.9	pKd	=	8.9	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization at 100 nM after 30 mins by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization at 100 nM after 30 mins by FLIPR assay	ChEMBL	654	15	0	6	8.2	O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCCc1ccc(OCCCN2CCCCCC2)cc1	10.1021/jm1013874
	1194	45	3	None	-	2	Guinea pig	8.9	pKd	=	8.9	Functional	Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.	ChEMBL	265	3	2	2	2.3	NCCc1cnc([nH]1)c1cccc(c1)Br	10.1016/s0960-894x(98)00461-2
	23786499	45	3	None	-	2	Guinea pig	8.9	pKd	=	8.9	Functional	Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.	ChEMBL	265	3	2	2	2.3	NCCc1cnc([nH]1)c1cccc(c1)Br	10.1016/s0960-894x(98)00461-2
	CHEMBL26116	45	3	None	-	2	Guinea pig	8.9	pKd	=	8.9	Functional	Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.	ChEMBL	265	3	2	2	2.3	NCCc1cnc([nH]1)c1cccc(c1)Br	10.1016/s0960-894x(98)00461-2
	10403687	2511	3	None	1	2	Guinea pig	8.9	pKd	=	8.9	Functional	Antagonism of guinea pig ileum contraction at 100 nM mepyramineAntagonism of guinea pig ileum contraction at 100 nM mepyramine	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	1205	2511	3	None	1	2	Guinea pig	8.9	pKd	=	8.9	Functional	Antagonism of guinea pig ileum contraction at 100 nM mepyramineAntagonism of guinea pig ileum contraction at 100 nM mepyramine	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	CHEMBL275035	2511	3	None	1	2	Guinea pig	8.9	pKd	=	8.9	Functional	Antagonism of guinea pig ileum contraction at 100 nM mepyramineAntagonism of guinea pig ileum contraction at 100 nM mepyramine	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	10042467	1426	1	None	-1	2	Guinea pig	8.9	pKd	=	8.9	Functional	Antagonism of guinea pig ileum contraction at 100 nM mepyramineAntagonism of guinea pig ileum contraction at 100 nM mepyramine	ChEMBL	333	8	1	2	4.3	CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C	10.1021/jm991056a
	1203	1426	1	None	-1	2	Guinea pig	8.9	pKd	=	8.9	Functional	Antagonism of guinea pig ileum contraction at 100 nM mepyramineAntagonism of guinea pig ileum contraction at 100 nM mepyramine	ChEMBL	333	8	1	2	4.3	CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C	10.1021/jm991056a
	CHEMBL11553	1426	1	None	-1	2	Guinea pig	8.9	pKd	=	8.9	Functional	Antagonism of guinea pig ileum contraction at 100 nM mepyramineAntagonism of guinea pig ileum contraction at 100 nM mepyramine	ChEMBL	333	8	1	2	4.3	CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C	10.1021/jm991056a
	1524	2181	96	None	-	18	Guinea pig	8.9	pKd	=	8.9	Functional	Antagonism against H1 histamine receptor of guinea pig ileumAntagonism against H1 histamine receptor of guinea pig ileum	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/0960-894X(95)00092-8
	197	2181	96	None	-	18	Guinea pig	8.9	pKd	=	8.9	Functional	Antagonism against H1 histamine receptor of guinea pig ileumAntagonism against H1 histamine receptor of guinea pig ileum	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/0960-894X(95)00092-8
	3822	2181	96	None	-	18	Guinea pig	8.9	pKd	=	8.9	Functional	Antagonism against H1 histamine receptor of guinea pig ileumAntagonism against H1 histamine receptor of guinea pig ileum	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/0960-894X(95)00092-8
	88	2181	96	None	-	18	Guinea pig	8.9	pKd	=	8.9	Functional	Antagonism against H1 histamine receptor of guinea pig ileumAntagonism against H1 histamine receptor of guinea pig ileum	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/0960-894X(95)00092-8
	CHEMBL51	2181	96	None	-	18	Guinea pig	8.9	pKd	=	8.9	Functional	Antagonism against H1 histamine receptor of guinea pig ileumAntagonism against H1 histamine receptor of guinea pig ileum	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/0960-894X(95)00092-8
	DB12465	2181	96	None	-	18	Guinea pig	8.9	pKd	=	8.9	Functional	Antagonism against H1 histamine receptor of guinea pig ileumAntagonism against H1 histamine receptor of guinea pig ileum	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/0960-894X(95)00092-8
	11791817	98303	0	None	-1	2	Guinea pig	8.9	pKd	=	8.9	Functional	Antagonism of guinea pig ileum contraction at 100 nM mepyramineAntagonism of guinea pig ileum contraction at 100 nM mepyramine	ChEMBL	345	9	2	2	4.5	c1ccc(C(CCc2nc(CCNC3CC3)c[nH]2)c2ccccc2)cc1	10.1021/jm991056a
	CHEMBL274831	98303	0	None	-1	2	Guinea pig	8.9	pKd	=	8.9	Functional	Antagonism of guinea pig ileum contraction at 100 nM mepyramineAntagonism of guinea pig ileum contraction at 100 nM mepyramine	ChEMBL	345	9	2	2	4.5	c1ccc(C(CCc2nc(CCNC3CC3)c[nH]2)c2ccccc2)cc1	10.1021/jm991056a
	25190253	161117	0	None	-	0	Human	8.9	pKd	=	8.9	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	460	10	0	5	5.4	CCCCc1cc(OC2CCN(CCCCS(=O)(=O)C(C)(C)C)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4095759	161117	0	None	-	0	Human	8.9	pKd	=	8.9	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	460	10	0	5	5.4	CCCCc1cc(OC2CCN(CCCCS(=O)(=O)C(C)(C)C)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4117136	161117	0	None	-	0	Human	8.9	pKd	=	8.9	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	460	10	0	5	5.4	CCCCc1cc(OC2CCN(CCCCS(=O)(=O)C(C)(C)C)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	10407870	106761	0	None	-	0	Guinea pig	8.9	pKd	=	8.9	Functional	Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.	ChEMBL	283	4	1	2	3.2	CN(C)CCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1	10.1016/s0960-894x(98)00461-2
	CHEMBL314438	106761	0	None	-	0	Guinea pig	8.9	pKd	=	8.9	Functional	Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.	ChEMBL	283	4	1	2	3.2	CN(C)CCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1	10.1016/s0960-894x(98)00461-2
	10688111	10040	1	None	2	2	Guinea pig	8.8	pKd	=	8.8	Functional	Antagonism of guinea pig ileum contraction at 100 nM mepyramineAntagonism of guinea pig ileum contraction at 100 nM mepyramine	ChEMBL	333	9	2	2	4.3	CCNCCc1c[nH]c(CCC(c2ccccc2)c2ccccc2)n1	10.1021/jm991056a
	CHEMBL11515	10040	1	None	2	2	Guinea pig	8.8	pKd	=	8.8	Functional	Antagonism of guinea pig ileum contraction at 100 nM mepyramineAntagonism of guinea pig ileum contraction at 100 nM mepyramine	ChEMBL	333	9	2	2	4.3	CCNCCc1c[nH]c(CCC(c2ccccc2)c2ccccc2)n1	10.1021/jm991056a
	57780020	143450	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux at 100 nM preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux at 100 nM preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	600	15	1	6	6.6	CCCCc1cc(N2CCN(CCc3ccc(OCCCN4CCCCCC4)cc3)CC2)c2nc(CCC(=O)O)ccc2c1	10.1016/j.bmcl.2016.11.022
	CHEMBL3898341	143450	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux at 100 nM preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux at 100 nM preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	600	15	1	6	6.6	CCCCc1cc(N2CCN(CCc3ccc(OCCCN4CCCCCC4)cc3)CC2)c2nc(CCC(=O)O)ccc2c1	10.1016/j.bmcl.2016.11.022
	10447834	1933	4	None	2	3	Guinea pig	8.8	pKd	=	8.8	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nM	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	4026	1933	4	None	2	3	Guinea pig	8.8	pKd	=	8.8	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nM	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	CHEMBL275507	1933	4	None	2	3	Guinea pig	8.8	pKd	=	8.8	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nM	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	13676694	103712	0	None	-	0	Guinea pig	8.8	pKd	=	8.8	Functional	H1-antihistamine activity in guinea pig ileumH1-antihistamine activity in guinea pig ileum	ChEMBL	467	7	1	8	4.0	Cc1c(OCCCN2CCN(Cc3ccc(Cl)cc3)CC2)ccc2c(O)c3nnnc-3oc12	10.1021/jm00161a022
	CHEMBL308791	103712	0	None	-	0	Guinea pig	8.8	pKd	=	8.8	Functional	H1-antihistamine activity in guinea pig ileumH1-antihistamine activity in guinea pig ileum	ChEMBL	467	7	1	8	4.0	Cc1c(OCCCN2CCN(Cc3ccc(Cl)cc3)CC2)ccc2c(O)c3nnnc-3oc12	10.1021/jm00161a022
	10410901	119747	0	None	23	2	Guinea pig	8.8	pKd	=	8.8	Functional	Apparent pA2 value of compound at 10 nM concentration of mepyramine in guinea pig ileumApparent pA2 value of compound at 10 nM concentration of mepyramine in guinea pig ileum	ChEMBL	438	13	2	3	5.7	c1ccc(C(CCc2nc(CCNCCCCc3ccccn3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
	CHEMBL347796	119747	0	None	23	2	Guinea pig	8.8	pKd	=	8.8	Functional	Apparent pA2 value of compound at 10 nM concentration of mepyramine in guinea pig ileumApparent pA2 value of compound at 10 nM concentration of mepyramine in guinea pig ileum	ChEMBL	438	13	2	3	5.7	c1ccc(C(CCc2nc(CCNCCCCc3ccccn3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
	10403687	2511	3	None	1	2	Guinea pig	8.8	pKd	=	8.8	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nM	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	1205	2511	3	None	1	2	Guinea pig	8.8	pKd	=	8.8	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nM	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	CHEMBL275035	2511	3	None	1	2	Guinea pig	8.8	pKd	=	8.8	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nM	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	10484346	98726	0	None	-	0	Guinea pig	8.7	pKd	=	8.7	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	646	22	2	11	5.8	COc1ccc(CN(CCN(C)CCCCCCNC(=O)CCCCCNc2ccc([N+](=O)[O-])c3nonc23)c2ccccn2)cc1	10.1016/s0960-894x(03)00113-6
	CHEMBL277848	98726	0	None	-	0	Guinea pig	8.7	pKd	=	8.7	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	646	22	2	11	5.8	COc1ccc(CN(CCN(C)CCCCCCNC(=O)CCCCCNc2ccc([N+](=O)[O-])c3nonc23)c2ccccn2)cc1	10.1016/s0960-894x(03)00113-6
	25190435	158404	0	None	-	0	Human	8.7	pKd	=	8.7	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	447	9	1	5	4.1	CCCCc1cc(OC2CCN(CCS(=O)(=O)NC(C)(C)C)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4090136	158404	0	None	-	0	Human	8.7	pKd	=	8.7	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	447	9	1	5	4.1	CCCCc1cc(OC2CCN(CCS(=O)(=O)NC(C)(C)C)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	25190373	161088	0	None	-	0	Human	8.7	pKd	=	8.7	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	461	12	1	5	4.5	CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)C(C)C)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4060765	161088	0	None	-	0	Human	8.7	pKd	=	8.7	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	461	12	1	5	4.5	CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)C(C)C)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4116847	161088	0	None	-	0	Human	8.7	pKd	=	8.7	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	461	12	1	5	4.5	CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)C(C)C)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	25190254	161103	0	None	-	0	Human	8.7	pKd	=	8.7	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	432	10	0	5	4.6	CCCCc1cc(OC2CCN(CCC(C)S(=O)(=O)CC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4068414	161103	0	None	-	0	Human	8.7	pKd	=	8.7	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	432	10	0	5	4.6	CCCCc1cc(OC2CCN(CCC(C)S(=O)(=O)CC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4117012	161103	0	None	-	0	Human	8.7	pKd	=	8.7	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	432	10	0	5	4.6	CCCCc1cc(OC2CCN(CCC(C)S(=O)(=O)CC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	3529324	208354	1	None	-	1	Guinea pig	8.7	pKd	=	8.7	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	306	6	0	3	3.3	CC(C)c1ccc(C2SCC(=O)N2CCCN(C)C)cc1	10.1021/jm00093a025
	CHEMBL1202934	208354	1	None	-	1	Guinea pig	8.7	pKd	=	8.7	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	306	6	0	3	3.3	CC(C)c1ccc(C2SCC(=O)N2CCCN(C)C)cc1	10.1021/jm00093a025
	CHEMBL99417	208354	1	None	-	1	Guinea pig	8.7	pKd	=	8.7	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	306	6	0	3	3.3	CC(C)c1ccc(C2SCC(=O)N2CCCN(C)C)cc1	10.1021/jm00093a025
	57780008	149726	0	None	-	0	Human	8.0	pKd	=	8	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux at 100 nM preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux at 100 nM preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	472	9	0	5	5.2	c1cnc2c(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)cccc2c1	10.1016/j.bmcl.2016.11.022
	CHEMBL3947980	149726	0	None	-	0	Human	8.0	pKd	=	8	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux at 100 nM preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux at 100 nM preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	472	9	0	5	5.2	c1cnc2c(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)cccc2c1	10.1016/j.bmcl.2016.11.022
	1204	1932	119	None	-3	10	Guinea pig	8.0	pKd	=	8	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (relaxation) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig aorta (relaxation) at a mepyramine concentration of 100 nM	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm991056a
	1247	1932	119	None	-3	10	Guinea pig	8.0	pKd	=	8	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (relaxation) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig aorta (relaxation) at a mepyramine concentration of 100 nM	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm991056a
	1375	1932	119	None	-3	10	Guinea pig	8.0	pKd	=	8	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (relaxation) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig aorta (relaxation) at a mepyramine concentration of 100 nM	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm991056a
	774	1932	119	None	-3	10	Guinea pig	8.0	pKd	=	8	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (relaxation) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig aorta (relaxation) at a mepyramine concentration of 100 nM	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm991056a
	CHEMBL90	1932	119	None	-3	10	Guinea pig	8.0	pKd	=	8	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (relaxation) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig aorta (relaxation) at a mepyramine concentration of 100 nM	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm991056a
	DB05381	1932	119	None	-3	10	Guinea pig	8.0	pKd	=	8	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (relaxation) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig aorta (relaxation) at a mepyramine concentration of 100 nM	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm991056a
	1204	1932	119	None	-9	10	Rat	8.0	pKd	=	8	Functional	Relative potency against Histamine H1 receptor in rat aortaRelative potency against Histamine H1 receptor in rat aorta	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0309147
	1247	1932	119	None	-9	10	Rat	8.0	pKd	=	8	Functional	Relative potency against Histamine H1 receptor in rat aortaRelative potency against Histamine H1 receptor in rat aorta	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0309147
	1375	1932	119	None	-9	10	Rat	8.0	pKd	=	8	Functional	Relative potency against Histamine H1 receptor in rat aortaRelative potency against Histamine H1 receptor in rat aorta	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0309147
	774	1932	119	None	-9	10	Rat	8.0	pKd	=	8	Functional	Relative potency against Histamine H1 receptor in rat aortaRelative potency against Histamine H1 receptor in rat aorta	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0309147
	CHEMBL90	1932	119	None	-9	10	Rat	8.0	pKd	=	8	Functional	Relative potency against Histamine H1 receptor in rat aortaRelative potency against Histamine H1 receptor in rat aorta	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0309147
	DB05381	1932	119	None	-9	10	Rat	8.0	pKd	=	8	Functional	Relative potency against Histamine H1 receptor in rat aortaRelative potency against Histamine H1 receptor in rat aorta	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0309147
	10364258	45769	0	None	-12	2	Rat	8.0	pKd	=	8.0	Functional	Apparent pA2 value of compound at 50 nM concentration of mepyramine in rat aortaApparent pA2 value of compound at 50 nM concentration of mepyramine in rat aorta	ChEMBL	410	11	2	3	4.9	c1ccc(C(CCc2nc(CCNCCc3ccccn3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
	CHEMBL153067	45769	0	None	-12	2	Rat	8.0	pKd	=	8.0	Functional	Apparent pA2 value of compound at 50 nM concentration of mepyramine in rat aortaApparent pA2 value of compound at 50 nM concentration of mepyramine in rat aorta	ChEMBL	410	11	2	3	4.9	c1ccc(C(CCc2nc(CCNCCc3ccccn3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
	10042467	1426	1	None	-1	2	Guinea pig	8.0	pKd	=	8.0	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (relaxation) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig aorta (relaxation) at a mepyramine concentration of 100 nM	ChEMBL	333	8	1	2	4.3	CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C	10.1021/jm991056a
	1203	1426	1	None	-1	2	Guinea pig	8.0	pKd	=	8.0	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (relaxation) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig aorta (relaxation) at a mepyramine concentration of 100 nM	ChEMBL	333	8	1	2	4.3	CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C	10.1021/jm991056a
	CHEMBL11553	1426	1	None	-1	2	Guinea pig	8.0	pKd	=	8.0	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (relaxation) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig aorta (relaxation) at a mepyramine concentration of 100 nM	ChEMBL	333	8	1	2	4.3	CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C	10.1021/jm991056a
	57402471	67876	0	None	-	0	Guinea pig	8.0	pKd	=	8.0	Functional	Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsAntagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins	ChEMBL	469	8	1	5	4.0	COc1ccc(CN(CCN2CCN(C(=O)c3cc4ccccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
	CHEMBL1910378	67876	0	None	-	0	Guinea pig	8.0	pKd	=	8.0	Functional	Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsAntagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins	ChEMBL	469	8	1	5	4.0	COc1ccc(CN(CCN2CCN(C(=O)c3cc4ccccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
	14113352	170208	0	None	-	0	Guinea pig	7.0	pKd	=	7	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	394	10	4	4	3.4	N=C(NCCCc1c[nH]cn1)NCCSC(c1ccccc1)c1ccccn1	10.1021/jm00128a045
	CHEMBL444531	170208	0	None	-	0	Guinea pig	7.0	pKd	=	7	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	394	10	4	4	3.4	N=C(NCCCc1c[nH]cn1)NCCSC(c1ccccc1)c1ccccn1	10.1021/jm00128a045
	14984030	107330	1	None	-	1	Guinea pig	6.0	pKd	=	6	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	279	5	1	4	1.8	CN(C)CCCN1C(=O)CSC1c1ccc(N)cc1	10.1021/jm00093a025
	CHEMBL1202935	107330	1	None	-	1	Guinea pig	6.0	pKd	=	6	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	279	5	1	4	1.8	CN(C)CCCN1C(=O)CSC1c1ccc(N)cc1	10.1021/jm00093a025
	CHEMBL317518	107330	1	None	-	1	Guinea pig	6.0	pKd	=	6	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	279	5	1	4	1.8	CN(C)CCCN1C(=O)CSC1c1ccc(N)cc1	10.1021/jm00093a025
	10246247	98293	0	None	-	0	Guinea pig	6.0	pKd	=	6	Functional	Relative potency was recorded in endothelium-denuded guinea pig; value ranges from 5.75 to 6.25Relative potency was recorded in endothelium-denuded guinea pig; value ranges from 5.75 to 6.25	ChEMBL	333	9	2	2	4.5	NCCc1c[nH]c(CCCCC(c2ccccc2)c2ccccc2)n1	10.1021/jm991056a
	CHEMBL274767	98293	0	None	-	0	Guinea pig	6.0	pKd	=	6	Functional	Relative potency was recorded in endothelium-denuded guinea pig; value ranges from 5.75 to 6.25Relative potency was recorded in endothelium-denuded guinea pig; value ranges from 5.75 to 6.25	ChEMBL	333	9	2	2	4.5	NCCc1c[nH]c(CCCCC(c2ccccc2)c2ccccc2)n1	10.1021/jm991056a
	10684712	11392	0	None	-	0	Guinea pig	5.0	pKd	=	5	Functional	Histamine H1-receptor activity on isolated guinea pig ileumHistamine H1-receptor activity on isolated guinea pig ileum	ChEMBL	287	8	2	4	3.4	CCC/C(=N\O)c1ccc(OCCCc2c[nH]cn2)cc1	10.1021/jm000971p
	CHEMBL112301	11392	0	None	-	0	Guinea pig	5.0	pKd	=	5	Functional	Histamine H1-receptor activity on isolated guinea pig ileumHistamine H1-receptor activity on isolated guinea pig ileum	ChEMBL	287	8	2	4	3.4	CCC/C(=N\O)c1ccc(OCCCc2c[nH]cn2)cc1	10.1021/jm000971p
	CHEMBL1180048	11392	0	None	-	0	Guinea pig	5.0	pKd	=	5	Functional	Histamine H1-receptor activity on isolated guinea pig ileumHistamine H1-receptor activity on isolated guinea pig ileum	ChEMBL	287	8	2	4	3.4	CCC/C(=N\O)c1ccc(OCCCc2c[nH]cn2)cc1	10.1021/jm000971p
	6422121	205449	1	None	-	0	Guinea pig	5.0	pKd	=	5	Functional	Histamine H1-receptor activity on isolated guinea pig ileumHistamine H1-receptor activity on isolated guinea pig ileum	ChEMBL	285	7	2	4	3.0	O/N=C(/c1ccc(OCCCc2c[nH]cn2)cc1)C1CC1	10.1021/jm000971p
	CHEMBL116270	205449	1	None	-	0	Guinea pig	5.0	pKd	=	5	Functional	Histamine H1-receptor activity on isolated guinea pig ileumHistamine H1-receptor activity on isolated guinea pig ileum	ChEMBL	285	7	2	4	3.0	O/N=C(/c1ccc(OCCCc2c[nH]cn2)cc1)C1CC1	10.1021/jm000971p
	CHEMBL80348	205449	1	None	-	0	Guinea pig	5.0	pKd	=	5	Functional	Histamine H1-receptor activity on isolated guinea pig ileumHistamine H1-receptor activity on isolated guinea pig ileum	ChEMBL	285	7	2	4	3.0	O/N=C(/c1ccc(OCCCc2c[nH]cn2)cc1)C1CC1	10.1021/jm000971p
	2860933	208172	3	None	-	0	Guinea pig	5.0	pKd	=	5	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	294	6	0	4	2.2	COc1ccc(C2SCC(=O)N2CCCN(C)C)cc1	10.1021/jm00093a025
	CHEMBL1202929	208172	3	None	-	0	Guinea pig	5.0	pKd	=	5	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	294	6	0	4	2.2	COc1ccc(C2SCC(=O)N2CCCN(C)C)cc1	10.1021/jm00093a025
	CHEMBL98319	208172	3	None	-	0	Guinea pig	5.0	pKd	=	5	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	294	6	0	4	2.2	COc1ccc(C2SCC(=O)N2CCCN(C)C)cc1	10.1021/jm00093a025
	54726349	112370	0	None	-	0	Guinea pig	4.0	pKd	=	4	Functional	H1-antihistamine activity on guinea pig ileumH1-antihistamine activity on guinea pig ileum	ChEMBL	363	6	1	8	1.4	CN1CCN(CCCOc2ccc3c(O)c([N+](=O)[O-])c(=O)oc3c2)CC1	10.1021/jm00377a013
	CHEMBL32953	112370	0	None	-	0	Guinea pig	4.0	pKd	=	4	Functional	H1-antihistamine activity on guinea pig ileumH1-antihistamine activity on guinea pig ileum	ChEMBL	363	6	1	8	1.4	CN1CCN(CCCOc2ccc3c(O)c([N+](=O)[O-])c(=O)oc3c2)CC1	10.1021/jm00377a013
	10246247	98293	0	None	-	0	Rat	6.0	pKd	=	6.0	Functional	Relative potency was recorded in in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619 valueRelative potency was recorded in in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619 value	ChEMBL	333	9	2	2	4.5	NCCc1c[nH]c(CCCCC(c2ccccc2)c2ccccc2)n1	10.1021/jm991056a
	CHEMBL274767	98293	0	None	-	0	Rat	6.0	pKd	=	6.0	Functional	Relative potency was recorded in in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619 valueRelative potency was recorded in in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619 value	ChEMBL	333	9	2	2	4.5	NCCc1c[nH]c(CCCCC(c2ccccc2)c2ccccc2)n1	10.1021/jm991056a
	11779175	63166	0	None	-	1	Guinea pig	5.0	pKd	=	5.0	Functional	Antagonist activity at histamine H1 receptor in guinea-pig ileumAntagonist activity at histamine H1 receptor in guinea-pig ileum	ChEMBL	293	8	2	3	3.4	O=C(NCCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
	CHEMBL1774600	63166	0	None	-	1	Guinea pig	5.0	pKd	=	5.0	Functional	Antagonist activity at histamine H1 receptor in guinea-pig ileumAntagonist activity at histamine H1 receptor in guinea-pig ileum	ChEMBL	293	8	2	3	3.4	O=C(NCCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
	CHEMBL1789801	63166	0	None	-	1	Guinea pig	5.0	pKd	=	5.0	Functional	Antagonist activity at histamine H1 receptor in guinea-pig ileumAntagonist activity at histamine H1 receptor in guinea-pig ileum	ChEMBL	293	8	2	3	3.4	O=C(NCCCC1CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
	14660374	100690	0	None	-	0	Guinea pig	6.0	pKd	=	6.0	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	394	9	3	3	3.6	CN(CCC(c1ccc(F)cc1)c1ccccn1)C(=N)NCCCc1c[nH]cn1	10.1021/jm00128a045
	CHEMBL292395	100690	0	None	-	0	Guinea pig	6.0	pKd	=	6.0	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	394	9	3	3	3.6	CN(CCC(c1ccc(F)cc1)c1ccccn1)C(=N)NCCCc1c[nH]cn1	10.1021/jm00128a045
	1224	1432	83	None	85	22	Guinea pig	7.9	pKd	=	7.9	Functional	Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsAntagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1016/j.bmcl.2011.09.001
	3100	1432	83	None	85	22	Guinea pig	7.9	pKd	=	7.9	Functional	Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsAntagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1016/j.bmcl.2011.09.001
	8980	1432	83	None	85	22	Guinea pig	7.9	pKd	=	7.9	Functional	Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsAntagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1016/j.bmcl.2011.09.001
	916	1432	83	None	85	22	Guinea pig	7.9	pKd	=	7.9	Functional	Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsAntagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1016/j.bmcl.2011.09.001
	CHEMBL657	1432	83	None	85	22	Guinea pig	7.9	pKd	=	7.9	Functional	Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsAntagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1016/j.bmcl.2011.09.001
	DB01075	1432	83	None	85	22	Guinea pig	7.9	pKd	=	7.9	Functional	Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsAntagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1016/j.bmcl.2011.09.001
	25149611	179175	0	None	-	0	Guinea pig	5.0	pKd	=	5.0	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	376	8	4	4	2.6	N=C(NCCCc1c[nH]cn1)NC(=O)CC(c1ccccc1)c1ccccn1	10.1021/jm800841w
	CHEMBL472272	179175	0	None	-	0	Guinea pig	5.0	pKd	=	5.0	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	376	8	4	4	2.6	N=C(NCCCc1c[nH]cn1)NC(=O)CC(c1ccccc1)c1ccccn1	10.1021/jm800841w
	14660410	199054	0	None	-	0	Guinea pig	6.9	pKd	=	6.9	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	396	9	4	4	2.1	N/C(=N\CCC(O)(c1ccc(F)cc1)c1ccccn1)NCCCc1c[nH]cn1	10.1021/jm00128a045
	CHEMBL58621	199054	0	None	-	0	Guinea pig	6.9	pKd	=	6.9	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	396	9	4	4	2.1	N/C(=N\CCC(O)(c1ccc(F)cc1)c1ccccn1)NCCCc1c[nH]cn1	10.1021/jm00128a045
	57398985	67883	0	None	-	0	Guinea pig	7.9	pKd	=	7.9	Functional	Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsAntagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins	ChEMBL	569	12	2	7	4.4	COc1ccc(CN(CCN(C)CC(C)Nc2ccc3[nH]c(C(=O)N4CCN(C)CC4)cc3c2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
	CHEMBL1910385	67883	0	None	-	0	Guinea pig	7.9	pKd	=	7.9	Functional	Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsAntagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins	ChEMBL	569	12	2	7	4.4	COc1ccc(CN(CCN(C)CC(C)Nc2ccc3[nH]c(C(=O)N4CCN(C)CC4)cc3c2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
	54710799	96781	0	None	-	0	Guinea pig	7.9	pKd	=	7.9	Functional	H1-antihistamine activity on guinea pig ileumH1-antihistamine activity on guinea pig ileum	ChEMBL	439	8	1	8	3.0	O=c1oc2cc(OCCCN3CCN(Cc4ccccc4)CC3)ccc2c(O)c1[N+](=O)[O-]	10.1021/jm00377a013
	CHEMBL264756	96781	0	None	-	0	Guinea pig	7.9	pKd	=	7.9	Functional	H1-antihistamine activity on guinea pig ileumH1-antihistamine activity on guinea pig ileum	ChEMBL	439	8	1	8	3.0	O=c1oc2cc(OCCCN3CCN(Cc4ccccc4)CC3)ccc2c(O)c1[N+](=O)[O-]	10.1021/jm00377a013
	19762600	79999	0	None	-	0	Guinea pig	7.9	pKd	=	7.9	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	370	13	1	5	3.5	COc1ccc(CN(CCN(C)CCCCCCN)c2ccccn2)cc1	10.1016/s0960-894x(03)00113-6
	CHEMBL21278	79999	0	None	-	0	Guinea pig	7.9	pKd	=	7.9	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	370	13	1	5	3.5	COc1ccc(CN(CCN(C)CCCCCCN)c2ccccn2)cc1	10.1016/s0960-894x(03)00113-6
	10003410	200642	0	None	-	0	Guinea pig	6.9	pKd	=	6.9	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	440	9	4	3	3.8	N=C(NCCCc1c[nH]cn1)NCCC(c1ccc(Br)cc1)c1ccccn1	10.1021/jm00128a045
	CHEMBL59951	200642	0	None	-	0	Guinea pig	6.9	pKd	=	6.9	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	440	9	4	3	3.8	N=C(NCCCc1c[nH]cn1)NCCC(c1ccc(Br)cc1)c1ccccn1	10.1021/jm00128a045
	10852834	11393	0	None	-	0	Guinea pig	4.9	pKd	=	4.9	Functional	Histamine H1-receptor activity on isolated guinea pig ileumHistamine H1-receptor activity on isolated guinea pig ileum	ChEMBL	315	10	2	4	4.2	CCCCC/C(=N\O)c1ccc(OCCCc2c[nH]cn2)cc1	10.1021/jm000971p
	CHEMBL112629	11393	0	None	-	0	Guinea pig	4.9	pKd	=	4.9	Functional	Histamine H1-receptor activity on isolated guinea pig ileumHistamine H1-receptor activity on isolated guinea pig ileum	ChEMBL	315	10	2	4	4.2	CCCCC/C(=N\O)c1ccc(OCCCc2c[nH]cn2)cc1	10.1021/jm000971p
	CHEMBL1180064	11393	0	None	-	0	Guinea pig	4.9	pKd	=	4.9	Functional	Histamine H1-receptor activity on isolated guinea pig ileumHistamine H1-receptor activity on isolated guinea pig ileum	ChEMBL	315	10	2	4	4.2	CCCCC/C(=N\O)c1ccc(OCCCc2c[nH]cn2)cc1	10.1021/jm000971p
	10659856	11397	0	None	-	0	Guinea pig	4.9	pKd	=	4.9	Functional	Histamine H1-receptor activity on isolated guinea pig ileumHistamine H1-receptor activity on isolated guinea pig ileum	ChEMBL	273	7	1	4	2.8	CO/N=C(\C)c1ccc(OCCCc2c[nH]cn2)cc1	10.1021/jm000971p
	CHEMBL112753	11397	0	None	-	0	Guinea pig	4.9	pKd	=	4.9	Functional	Histamine H1-receptor activity on isolated guinea pig ileumHistamine H1-receptor activity on isolated guinea pig ileum	ChEMBL	273	7	1	4	2.8	CO/N=C(\C)c1ccc(OCCCc2c[nH]cn2)cc1	10.1021/jm000971p
	CHEMBL1180075	11397	0	None	-	0	Guinea pig	4.9	pKd	=	4.9	Functional	Histamine H1-receptor activity on isolated guinea pig ileumHistamine H1-receptor activity on isolated guinea pig ileum	ChEMBL	273	7	1	4	2.8	CO/N=C(\C)c1ccc(OCCCc2c[nH]cn2)cc1	10.1021/jm000971p
	10828008	11410	0	None	-	0	Guinea pig	4.9	pKd	=	4.9	Functional	Histamine H1-receptor activity on isolated guinea pig ileumHistamine H1-receptor activity on isolated guinea pig ileum	ChEMBL	299	6	1	3	2.7	O=C(c1ccc(OCCCc2c[nH]cn2)cc1)N1CCCC1	10.1021/jm000971p
	CHEMBL115169	11410	0	None	-	0	Guinea pig	4.9	pKd	=	4.9	Functional	Histamine H1-receptor activity on isolated guinea pig ileumHistamine H1-receptor activity on isolated guinea pig ileum	ChEMBL	299	6	1	3	2.7	O=C(c1ccc(OCCCc2c[nH]cn2)cc1)N1CCCC1	10.1021/jm000971p
	CHEMBL1180148	11410	0	None	-	0	Guinea pig	4.9	pKd	=	4.9	Functional	Histamine H1-receptor activity on isolated guinea pig ileumHistamine H1-receptor activity on isolated guinea pig ileum	ChEMBL	299	6	1	3	2.7	O=C(c1ccc(OCCCc2c[nH]cn2)cc1)N1CCCC1	10.1021/jm000971p
	19762590	162263	1	None	-	0	Guinea pig	7.9	pKd	=	7.9	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	314	9	1	5	2.0	COc1ccc(CN(CCN(C)CCN)c2ccccn2)cc1	10.1016/s0960-894x(03)00113-6
	CHEMBL416378	162263	1	None	-	0	Guinea pig	7.9	pKd	=	7.9	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	314	9	1	5	2.0	COc1ccc(CN(CCN(C)CCN)c2ccccn2)cc1	10.1016/s0960-894x(03)00113-6
	25149335	184225	0	None	-	3	Guinea pig	5.9	pKd	=	5.9	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions	ChEMBL	313	7	3	2	2.0	CC(CC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1021/jm9000693
	CHEMBL483406	184225	0	None	-	3	Guinea pig	5.9	pKd	=	5.9	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions	ChEMBL	313	7	3	2	2.0	CC(CC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1021/jm9000693
	25149335	184225	0	None	-	3	Guinea pig	5.9	pKd	=	5.9	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	313	7	3	2	2.0	CC(CC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1021/jm800841w
	CHEMBL483406	184225	0	None	-	3	Guinea pig	5.9	pKd	=	5.9	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	313	7	3	2	2.0	CC(CC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1021/jm800841w
	52949049	10555	0	None	-	0	Guinea pig	7.8	pKd	=	7.8	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	673	17	1	7	7.2	COc1ccc(CN(CCN(C)CCCCCCNC(=O)CCC2=C3C(C)=CC(C)N3[B-](F)(F)n3c(C)cc(C)c32)c2ccccn2)cc1	10.1016/s0960-894x(03)00113-6
	CHEMBL1169587	10555	0	None	-	0	Guinea pig	7.8	pKd	=	7.8	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	673	17	1	7	7.2	COc1ccc(CN(CCN(C)CCCCCCNC(=O)CCC2=C3C(C)=CC(C)N3[B-](F)(F)n3c(C)cc(C)c32)c2ccccn2)cc1	10.1016/s0960-894x(03)00113-6
	14660389	202293	0	None	-	0	Guinea pig	6.9	pKd	=	6.9	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	393	10	4	2	4.0	N=C(NCCCc1c[nH]cn1)NCCC(Cc1ccccc1)c1ccc(F)cc1	10.1021/jm00128a045
	CHEMBL61022	202293	0	None	-	0	Guinea pig	6.9	pKd	=	6.9	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	393	10	4	2	4.0	N=C(NCCCc1c[nH]cn1)NCCC(Cc1ccccc1)c1ccc(F)cc1	10.1021/jm00128a045
	44457703	99546	0	None	-	0	Guinea pig	6.8	pKd	=	6.8	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	672	13	3	9	5.7	COc1ccc(CN(CCN(C)CCNC(=O)c2ccc(C(=O)O)c(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c2)c2ccccn2)cc1	10.1016/s0960-894x(03)00113-6
	CHEMBL283527	99546	0	None	-	0	Guinea pig	6.8	pKd	=	6.8	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	672	13	3	9	5.7	COc1ccc(CN(CCN(C)CCNC(=O)c2ccc(C(=O)O)c(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c2)c2ccccn2)cc1	10.1016/s0960-894x(03)00113-6
	14660348	199654	0	None	-	0	Guinea pig	6.8	pKd	=	6.8	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	376	9	3	3	3.2	Cc1ccc(C(CC/N=C(\N)NCCCc2c[nH]cn2)c2ccccn2)cc1	10.1021/jm00128a045
	CHEMBL59294	199654	0	None	-	0	Guinea pig	6.8	pKd	=	6.8	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	376	9	3	3	3.2	Cc1ccc(C(CC/N=C(\N)NCCCc2c[nH]cn2)c2ccccn2)cc1	10.1021/jm00128a045
	13676692	105484	0	None	-	0	Guinea pig	7.8	pKd	=	7.8	Functional	Compound was tested for H1-antihistamine activity in guinea pig ileum.Compound was tested for H1-antihistamine activity in guinea pig ileum.	ChEMBL	447	7	1	8	3.6	Cc1ccc(CN2CCN(CCCOc3ccc4c(O)c5nnnc-5oc4c3C)CC2)cc1	10.1021/jm00161a022
	CHEMBL312083	105484	0	None	-	0	Guinea pig	7.8	pKd	=	7.8	Functional	Compound was tested for H1-antihistamine activity in guinea pig ileum.Compound was tested for H1-antihistamine activity in guinea pig ileum.	ChEMBL	447	7	1	8	3.6	Cc1ccc(CN2CCN(CCCOc3ccc4c(O)c5nnnc-5oc4c3C)CC2)cc1	10.1021/jm00161a022
	13676699	163768	0	None	-	0	Guinea pig	7.8	pKd	=	7.8	Functional	H1-antihistamine activity in guinea pig ileumH1-antihistamine activity in guinea pig ileum	ChEMBL	434	7	1	9	2.7	Cc1c(OCCCN2CCN(Cc3ccccn3)CC2)ccc2c(O)c3nnnc-3oc12	10.1021/jm00161a022
	CHEMBL420567	163768	0	None	-	0	Guinea pig	7.8	pKd	=	7.8	Functional	H1-antihistamine activity in guinea pig ileumH1-antihistamine activity in guinea pig ileum	ChEMBL	434	7	1	9	2.7	Cc1c(OCCCN2CCN(Cc3ccccn3)CC2)ccc2c(O)c3nnnc-3oc12	10.1021/jm00161a022
	14660357	202702	0	None	-	0	Guinea pig	6.8	pKd	=	6.8	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	380	9	4	3	3.2	N=C(NCCCc1c[nH]cn1)NCCC(c1cccc(F)c1)c1ccccn1	10.1021/jm00128a045
	CHEMBL61675	202702	0	None	-	0	Guinea pig	6.8	pKd	=	6.8	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	380	9	4	3	3.2	N=C(NCCCc1c[nH]cn1)NCCC(c1cccc(F)c1)c1ccccn1	10.1021/jm00128a045
	54710801	99907	0	None	-	0	Guinea pig	6.8	pKd	=	6.8	Functional	H1-antihistamine activity on guinea pig ileumH1-antihistamine activity on guinea pig ileum	ChEMBL	459	7	1	8	3.3	O=c1oc2cc(OCCN3CCN(Cc4ccc(Cl)cc4)CC3)ccc2c(O)c1[N+](=O)[O-]	10.1021/jm00377a013
	CHEMBL286094	99907	0	None	-	0	Guinea pig	6.8	pKd	=	6.8	Functional	H1-antihistamine activity on guinea pig ileumH1-antihistamine activity on guinea pig ileum	ChEMBL	459	7	1	8	3.3	O=c1oc2cc(OCCN3CCN(Cc4ccc(Cl)cc4)CC3)ccc2c(O)c1[N+](=O)[O-]	10.1021/jm00377a013
	10825231	9630	1	None	-	0	Guinea pig	6.8	pKd	=	6.8	Functional	Histamine H1-receptor activity on isolated guinea pig ileumHistamine H1-receptor activity on isolated guinea pig ileum	ChEMBL	260	6	1	4	2.2	COC(=O)c1ccc(OCCCc2c[nH]cn2)cc1	10.1021/jm000971p
	CHEMBL112670	9630	1	None	-	0	Guinea pig	6.8	pKd	=	6.8	Functional	Histamine H1-receptor activity on isolated guinea pig ileumHistamine H1-receptor activity on isolated guinea pig ileum	ChEMBL	260	6	1	4	2.2	COC(=O)c1ccc(OCCCc2c[nH]cn2)cc1	10.1021/jm000971p
	1278	2150	84	None	-	4	Guinea pig	5.8	pKd	=	5.8	Functional	Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsAntagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.09.001
	1279	2150	84	None	-	4	Guinea pig	5.8	pKd	=	5.8	Functional	Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsAntagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.09.001
	4908365	2150	84	None	-	4	Guinea pig	5.8	pKd	=	5.8	Functional	Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsAntagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.09.001
	CHEMBL129198	2150	84	None	-	4	Guinea pig	5.8	pKd	=	5.8	Functional	Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsAntagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.09.001
	15179507	204179	0	None	-	0	Guinea pig	5.8	pKd	=	5.8	Functional	Histamine H1 receptor antagonistic activity on the isolated guinea pig ileum determined by Schild plot.Histamine H1 receptor antagonistic activity on the isolated guinea pig ileum determined by Schild plot.	ChEMBL	729	11	4	6	3.7	N#CN/C(=N\CCNC(=O)c1cc(I)c(N)c(I)c1)NCCCOc1cccc(CN2CCCCC2)c1	10.1021/jm00090a013
	CHEMBL70746	204179	0	None	-	0	Guinea pig	5.8	pKd	=	5.8	Functional	Histamine H1 receptor antagonistic activity on the isolated guinea pig ileum determined by Schild plot.Histamine H1 receptor antagonistic activity on the isolated guinea pig ileum determined by Schild plot.	ChEMBL	729	11	4	6	3.7	N#CN/C(=N\CCNC(=O)c1cc(I)c(N)c(I)c1)NCCCOc1cccc(CN2CCCCC2)c1	10.1021/jm00090a013
	11459067	11348	0	None	-	0	Guinea pig	4.8	pKd	=	4.8	Functional	Functional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileumFunctional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileum	ChEMBL	238	11	1	2	3.7	CCCCCCCCOCCCc1c[nH]cn1	10.1021/jm031065q
	CHEMBL1179647	11348	0	None	-	0	Guinea pig	4.8	pKd	=	4.8	Functional	Functional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileumFunctional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileum	ChEMBL	238	11	1	2	3.7	CCCCCCCCOCCCc1c[nH]cn1	10.1021/jm031065q
	CHEMBL91523	11348	0	None	-	0	Guinea pig	4.8	pKd	=	4.8	Functional	Functional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileumFunctional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileum	ChEMBL	238	11	1	2	3.7	CCCCCCCCOCCCc1c[nH]cn1	10.1021/jm031065q
	10730975	12105	0	None	-	0	Guinea pig	4.8	pKd	=	4.8	Functional	Histamine H1-receptor activity on isolated guinea pig ileumHistamine H1-receptor activity on isolated guinea pig ileum	ChEMBL	273	6	2	4	2.9	C/C(=N\O)c1ccc(OCCCc2c[nH]cn2)c(C)c1	10.1021/jm000971p
	CHEMBL1183977	12105	0	None	-	0	Guinea pig	4.8	pKd	=	4.8	Functional	Histamine H1-receptor activity on isolated guinea pig ileumHistamine H1-receptor activity on isolated guinea pig ileum	ChEMBL	273	6	2	4	2.9	C/C(=N\O)c1ccc(OCCCc2c[nH]cn2)c(C)c1	10.1021/jm000971p
	CHEMBL326624	12105	0	None	-	0	Guinea pig	4.8	pKd	=	4.8	Functional	Histamine H1-receptor activity on isolated guinea pig ileumHistamine H1-receptor activity on isolated guinea pig ileum	ChEMBL	273	6	2	4	2.9	C/C(=N\O)c1ccc(OCCCc2c[nH]cn2)c(C)c1	10.1021/jm000971p
	14660414	199072	0	None	-	0	Guinea pig	5.8	pKd	=	5.8	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	407	10	3	5	2.8	N/C(=N\CCC(c1cccc([N+](=O)[O-])c1)c1ccccn1)NCCCc1c[nH]cn1	10.1021/jm00128a045
	CHEMBL58750	199072	0	None	-	0	Guinea pig	5.8	pKd	=	5.8	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	407	10	3	5	2.8	N/C(=N\CCC(c1cccc([N+](=O)[O-])c1)c1ccccn1)NCCCc1c[nH]cn1	10.1021/jm00128a045
	44457690	85526	0	None	-	0	Guinea pig	7.8	pKd	=	7.8	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	603	17	1	7	5.8	COc1ccc(CN(CCN(C)CCCCCCNS(=O)(=O)c2cccc3c(N(C)C)cccc23)c2ccccn2)cc1	10.1016/s0960-894x(03)00113-6
	CHEMBL22749	85526	0	None	-	0	Guinea pig	7.8	pKd	=	7.8	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	603	17	1	7	5.8	COc1ccc(CN(CCN(C)CCCCCCNS(=O)(=O)c2cccc3c(N(C)C)cccc23)c2ccccn2)cc1	10.1016/s0960-894x(03)00113-6
	25149427	185961	0	None	-	0	Guinea pig	5.7	pKd	=	5.7	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	313	8	4	3	2.0	N=C(NCCCc1c[nH]cn1)NC(=O)CCCc1ccccc1	10.1021/jm800841w
	CHEMBL486962	185961	0	None	-	0	Guinea pig	5.7	pKd	=	5.7	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	313	8	4	3	2.0	N=C(NCCCc1c[nH]cn1)NC(=O)CCCc1ccccc1	10.1021/jm800841w
	10423703	107295	0	None	-	1	Guinea pig	7.7	pKd	=	7.7	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	278	5	0	3	2.5	Cc1cccc(C2SCC(=O)N2CCCN(C)C)c1	10.1021/jm00093a025
	CHEMBL1202942	107295	0	None	-	1	Guinea pig	7.7	pKd	=	7.7	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	278	5	0	3	2.5	Cc1cccc(C2SCC(=O)N2CCCN(C)C)c1	10.1021/jm00093a025
	CHEMBL317171	107295	0	None	-	1	Guinea pig	7.7	pKd	=	7.7	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	278	5	0	3	2.5	Cc1cccc(C2SCC(=O)N2CCCN(C)C)c1	10.1021/jm00093a025
	14660380	198707	0	None	-	0	Guinea pig	6.7	pKd	=	6.7	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	380	9	4	3	3.2	N=C(NCCCc1c[nH]cn1)NCCC(c1ccc(F)cc1)c1cccnc1	10.1021/jm00128a045
	CHEMBL58170	198707	0	None	-	0	Guinea pig	6.7	pKd	=	6.7	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	380	9	4	3	3.2	N=C(NCCCc1c[nH]cn1)NCCC(c1ccc(F)cc1)c1cccnc1	10.1021/jm00128a045
	10342634	200019	0	None	-	0	Guinea pig	6.7	pKd	=	6.7	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	429	9	4	2	5.0	N=C(NCCCc1c[nH]cn1)NCCC(c1ccccc1)c1ccc(Cl)c(Cl)c1	10.1021/jm00128a045
	CHEMBL59544	200019	0	None	-	0	Guinea pig	6.7	pKd	=	6.7	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	429	9	4	2	5.0	N=C(NCCCc1c[nH]cn1)NCCC(c1ccccc1)c1ccc(Cl)c(Cl)c1	10.1021/jm00128a045
	11436304	11337	0	None	-	0	Guinea pig	4.7	pKd	=	4.7	Functional	Functional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileumFunctional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileum	ChEMBL	236	8	1	2	3.3	c1nc(CCCOCCCC2CCCC2)c[nH]1	10.1021/jm031065q
	CHEMBL1179594	11337	0	None	-	0	Guinea pig	4.7	pKd	=	4.7	Functional	Functional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileumFunctional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileum	ChEMBL	236	8	1	2	3.3	c1nc(CCCOCCCC2CCCC2)c[nH]1	10.1021/jm031065q
	CHEMBL88306	11337	0	None	-	0	Guinea pig	4.7	pKd	=	4.7	Functional	Functional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileumFunctional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileum	ChEMBL	236	8	1	2	3.3	c1nc(CCCOCCCC2CCCC2)c[nH]1	10.1021/jm031065q
	10375442	11340	0	None	-	1	Guinea pig	4.7	pKd	=	4.7	Functional	Functional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileumFunctional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileum	ChEMBL	196	8	1	2	2.5	CCCCCOCCCc1c[nH]cn1	10.1021/jm031065q
	CHEMBL1179604	11340	0	None	-	1	Guinea pig	4.7	pKd	=	4.7	Functional	Functional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileumFunctional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileum	ChEMBL	196	8	1	2	2.5	CCCCCOCCCc1c[nH]cn1	10.1021/jm031065q
	CHEMBL88746	11340	0	None	-	1	Guinea pig	4.7	pKd	=	4.7	Functional	Functional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileumFunctional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileum	ChEMBL	196	8	1	2	2.5	CCCCCOCCCc1c[nH]cn1	10.1021/jm031065q
	25190258	161152	0	None	-	0	Human	8.7	pKd	=	8.7	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	419	10	1	5	3.4	CCCCc1cc(OC2CCN(CCNS(=O)(=O)CC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4079248	161152	0	None	-	0	Human	8.7	pKd	=	8.7	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	419	10	1	5	3.4	CCCCc1cc(OC2CCN(CCNS(=O)(=O)CC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4117327	161152	0	None	-	0	Human	8.7	pKd	=	8.7	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	419	10	1	5	3.4	CCCCc1cc(OC2CCN(CCNS(=O)(=O)CC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	11791817	98303	0	None	-1	2	Guinea pig	8.7	pKd	=	8.7	Functional	Antagonism of guinea pig ileum contraction at 100 nM mepyramineAntagonism of guinea pig ileum contraction at 100 nM mepyramine	ChEMBL	345	9	2	2	4.5	c1ccc(C(CCc2nc(CCNC3CC3)c[nH]2)c2ccccc2)cc1	10.1021/jm991056a
	CHEMBL274831	98303	0	None	-1	2	Guinea pig	8.7	pKd	=	8.7	Functional	Antagonism of guinea pig ileum contraction at 100 nM mepyramineAntagonism of guinea pig ileum contraction at 100 nM mepyramine	ChEMBL	345	9	2	2	4.5	c1ccc(C(CCc2nc(CCNC3CC3)c[nH]2)c2ccccc2)cc1	10.1021/jm991056a
	71449250	80471	0	None	-	0	Human	8.6	pKd	=	8.6	Functional	Antagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assayAntagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assay	ChEMBL	368	4	0	5	3.1	CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccncc2c1=O	10.1016/j.bmc.2012.08.032
	CHEMBL2146804	80471	0	None	-	0	Human	8.6	pKd	=	8.6	Functional	Antagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assayAntagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assay	ChEMBL	368	4	0	5	3.1	CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccncc2c1=O	10.1016/j.bmc.2012.08.032
	57780007	146991	0	None	-	0	Human	8.6	pKd	=	8.6	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux at 100 nM preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux at 100 nM preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	572	13	1	6	5.8	CCc1cc(N2CCN(CCc3ccc(OCCCN4CCCCCC4)cc3)CC2)c2nc(CCC(=O)O)ccc2c1	10.1016/j.bmcl.2016.11.022
	CHEMBL3926412	146991	0	None	-	0	Human	8.6	pKd	=	8.6	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux at 100 nM preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux at 100 nM preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	572	13	1	6	5.8	CCc1cc(N2CCN(CCc3ccc(OCCCN4CCCCCC4)cc3)CC2)c2nc(CCC(=O)O)ccc2c1	10.1016/j.bmcl.2016.11.022
	25190254	161103	0	None	-	0	Human	8.6	pKd	=	8.6	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	432	10	0	5	4.6	CCCCc1cc(OC2CCN(CCC(C)S(=O)(=O)CC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4068414	161103	0	None	-	0	Human	8.6	pKd	=	8.6	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	432	10	0	5	4.6	CCCCc1cc(OC2CCN(CCC(C)S(=O)(=O)CC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4117012	161103	0	None	-	0	Human	8.6	pKd	=	8.6	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	432	10	0	5	4.6	CCCCc1cc(OC2CCN(CCC(C)S(=O)(=O)CC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	10042467	1426	1	None	-1	2	Guinea pig	8.6	pKd	=	8.6	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nM	ChEMBL	333	8	1	2	4.3	CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C	10.1021/jm991056a
	1203	1426	1	None	-1	2	Guinea pig	8.6	pKd	=	8.6	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nM	ChEMBL	333	8	1	2	4.3	CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C	10.1021/jm991056a
	CHEMBL11553	1426	1	None	-1	2	Guinea pig	8.6	pKd	=	8.6	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nM	ChEMBL	333	8	1	2	4.3	CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C	10.1021/jm991056a
	57390224	67877	0	None	-	0	Guinea pig	7.7	pKd	=	7.7	Functional	Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsAntagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins	ChEMBL	503	8	1	5	4.7	COc1ccc(CN(CCN2CCN(C(=O)c3cc4cc(Cl)ccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
	CHEMBL1910379	67877	0	None	-	0	Guinea pig	7.7	pKd	=	7.7	Functional	Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsAntagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins	ChEMBL	503	8	1	5	4.7	COc1ccc(CN(CCN2CCN(C(=O)c3cc4cc(Cl)ccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
	44457702	83169	0	None	-	0	Guinea pig	7.7	pKd	=	7.7	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	728	17	3	9	7.3	COc1ccc(CN(CCN(C)CCCCCCNC(=O)c2ccc(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c(C(=O)O)c2)c2ccccn2)cc1	10.1016/s0960-894x(03)00113-6
	CHEMBL21833	83169	0	None	-	0	Guinea pig	7.7	pKd	=	7.7	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	728	17	3	9	7.3	COc1ccc(CN(CCN(C)CCCCCCNC(=O)c2ccc(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c(C(=O)O)c2)c2ccccn2)cc1	10.1016/s0960-894x(03)00113-6
	25149712	178986	0	None	-	3	Guinea pig	5.7	pKd	=	5.7	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	299	7	4	3	1.6	N=C(NCCCc1c[nH]cn1)NC(=O)CCc1ccccc1	10.1021/jm800841w
	CHEMBL470790	178986	0	None	-	3	Guinea pig	5.7	pKd	=	5.7	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	299	7	4	3	1.6	N=C(NCCCc1c[nH]cn1)NC(=O)CCc1ccccc1	10.1021/jm800841w
	11956130	185965	0	None	-	0	Guinea pig	5.7	pKd	=	5.7	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	319	7	4	3	2.6	CC(CC(=O)NC(=N)NCCCc1c[nH]cn1)C1CCCCC1	10.1021/jm800841w
	CHEMBL486965	185965	0	None	-	0	Guinea pig	5.7	pKd	=	5.7	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	319	7	4	3	2.6	CC(CC(=O)NC(=N)NCCCc1c[nH]cn1)C1CCCCC1	10.1021/jm800841w
	1221	475	9	None	-	0	Guinea pig	7.7	pKd	=	7.7	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	380	9	3	3	3.0	NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)F	10.1021/jm00128a045
	65895	475	9	None	-	0	Guinea pig	7.7	pKd	=	7.7	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	380	9	3	3	3.0	NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)F	10.1021/jm00128a045
	CHEMBL293802	475	9	None	-	0	Guinea pig	7.7	pKd	=	7.7	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	380	9	3	3	3.0	NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)F	10.1021/jm00128a045
	1221	475	9	None	-	0	Guinea pig	7.7	pKd	=	7.7	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	380	9	3	3	3.0	NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)F	10.1021/jm800841w
	65895	475	9	None	-	0	Guinea pig	7.7	pKd	=	7.7	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	380	9	3	3	3.0	NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)F	10.1021/jm800841w
	CHEMBL293802	475	9	None	-	0	Guinea pig	7.7	pKd	=	7.7	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	380	9	3	3	3.0	NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)F	10.1021/jm800841w
	19762580	80793	0	None	-	0	Guinea pig	7.7	pKd	=	7.7	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	342	11	1	5	2.8	COc1ccc(CN(CCN(C)CCCCN)c2ccccn2)cc1	10.1016/s0960-894x(03)00113-6
	CHEMBL21520	80793	0	None	-	0	Guinea pig	7.7	pKd	=	7.7	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	342	11	1	5	2.8	COc1ccc(CN(CCN(C)CCCCN)c2ccccn2)cc1	10.1016/s0960-894x(03)00113-6
	15179508	204695	0	None	-	0	Guinea pig	5.7	pKd	=	5.7	Functional	Histamine H1 receptor antagonistic activity on the isolated guinea pig ileum determined by Schild plot.Histamine H1 receptor antagonistic activity on the isolated guinea pig ileum determined by Schild plot.	ChEMBL	588	11	3	5	3.5	N#CN/C(=N\CCNC(=O)c1cccc(I)c1)NCCCOc1cccc(CN2CCCCC2)c1	10.1021/jm00090a013
	CHEMBL73994	204695	0	None	-	0	Guinea pig	5.7	pKd	=	5.7	Functional	Histamine H1 receptor antagonistic activity on the isolated guinea pig ileum determined by Schild plot.Histamine H1 receptor antagonistic activity on the isolated guinea pig ileum determined by Schild plot.	ChEMBL	588	11	3	5	3.5	N#CN/C(=N\CCNC(=O)c1cccc(I)c1)NCCCOc1cccc(CN2CCCCC2)c1	10.1021/jm00090a013
	14660391	199053	0	None	-	0	Guinea pig	6.6	pKd	=	6.6	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	272	5	3	2	2.2	N=C(N)NCCC(c1ccc(F)cc1)c1ccccn1	10.1021/jm00128a045
	CHEMBL58620	199053	0	None	-	0	Guinea pig	6.6	pKd	=	6.6	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	272	5	3	2	2.2	N=C(N)NCCC(c1ccc(F)cc1)c1ccccn1	10.1021/jm00128a045
	25149429	185964	0	None	-	0	Guinea pig	5.6	pKd	=	5.6	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	305	6	4	3	2.2	CC(C(=O)NC(=N)NCCCc1c[nH]cn1)C1CCCCC1	10.1021/jm800841w
	CHEMBL486964	185964	0	None	-	0	Guinea pig	5.6	pKd	=	5.6	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	305	6	4	3	2.2	CC(C(=O)NC(=N)NCCCc1c[nH]cn1)C1CCCCC1	10.1021/jm800841w
	25149814	185324	0	None	-	0	Guinea pig	5.6	pKd	=	5.6	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	291	6	4	3	2.0	N=C(NCCCc1c[nH]cn1)NC(=O)CC1CCCCC1	10.1021/jm800841w
	CHEMBL485958	185324	0	None	-	0	Guinea pig	5.6	pKd	=	5.6	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	291	6	4	3	2.0	N=C(NCCCc1c[nH]cn1)NC(=O)CC1CCCCC1	10.1021/jm800841w
	10022429	162789	0	None	-	0	Guinea pig	6.6	pKd	=	6.6	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	376	10	4	3	3.5	N=C(NCCCc1c[nH]cn1)NCCCC(c1ccccc1)c1ccccn1	10.1021/jm00128a045
	CHEMBL417221	162789	0	None	-	0	Guinea pig	6.6	pKd	=	6.6	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	376	10	4	3	3.5	N=C(NCCCc1c[nH]cn1)NCCCC(c1ccccc1)c1ccccn1	10.1021/jm00128a045
	11276413	12071	0	None	-	0	Guinea pig	5.6	pKd	=	5.6	Functional	Functional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileumFunctional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileum	ChEMBL	236	7	1	2	3.3	c1nc(CCCOCCC2CCCCC2)c[nH]1	10.1021/jm031065q
	CHEMBL1183700	12071	0	None	-	0	Guinea pig	5.6	pKd	=	5.6	Functional	Functional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileumFunctional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileum	ChEMBL	236	7	1	2	3.3	c1nc(CCCOCCC2CCCCC2)c[nH]1	10.1021/jm031065q
	CHEMBL313803	12071	0	None	-	0	Guinea pig	5.6	pKd	=	5.6	Functional	Functional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileumFunctional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileum	ChEMBL	236	7	1	2	3.3	c1nc(CCCOCCC2CCCCC2)c[nH]1	10.1021/jm031065q
	54710792	126417	0	None	-	0	Guinea pig	5.6	pKd	=	5.6	Functional	H1-antihistamine activity on guinea pig ileumH1-antihistamine activity on guinea pig ileum	ChEMBL	429	5	1	7	3.4	O=c1oc2cc(CN3CCN(Cc4ccc(Cl)cc4)CC3)ccc2c(O)c1[N+](=O)[O-]	10.1021/jm00377a013
	CHEMBL36517	126417	0	None	-	0	Guinea pig	5.6	pKd	=	5.6	Functional	H1-antihistamine activity on guinea pig ileumH1-antihistamine activity on guinea pig ileum	ChEMBL	429	5	1	7	3.4	O=c1oc2cc(CN3CCN(Cc4ccc(Cl)cc4)CC3)ccc2c(O)c1[N+](=O)[O-]	10.1021/jm00377a013
	2861271	4254	9	None	-	1	Guinea pig	5.6	pKd	=	5.6	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	298	5	0	3	2.9	CN(C)CCCN1C(=O)CSC1c1ccc(Cl)cc1	10.1021/jm00093a025
	CHEMBL100486	4254	9	None	-	1	Guinea pig	5.6	pKd	=	5.6	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	298	5	0	3	2.9	CN(C)CCCN1C(=O)CSC1c1ccc(Cl)cc1	10.1021/jm00093a025
	10729993	11408	1	None	-	0	Guinea pig	4.6	pKd	=	4.6	Functional	Histamine H1-receptor activity on isolated guinea pig ileumHistamine H1-receptor activity on isolated guinea pig ileum	ChEMBL	259	6	2	4	2.6	C/C(=N\O)c1ccc(OCCCc2c[nH]cn2)cc1	10.1021/jm000971p
	CHEMBL114085	11408	1	None	-	0	Guinea pig	4.6	pKd	=	4.6	Functional	Histamine H1-receptor activity on isolated guinea pig ileumHistamine H1-receptor activity on isolated guinea pig ileum	ChEMBL	259	6	2	4	2.6	C/C(=N\O)c1ccc(OCCCc2c[nH]cn2)cc1	10.1021/jm000971p
	CHEMBL1180120	11408	1	None	-	0	Guinea pig	4.6	pKd	=	4.6	Functional	Histamine H1-receptor activity on isolated guinea pig ileumHistamine H1-receptor activity on isolated guinea pig ileum	ChEMBL	259	6	2	4	2.6	C/C(=N\O)c1ccc(OCCCc2c[nH]cn2)cc1	10.1021/jm000971p
	10492497	12374	0	None	-	0	Guinea pig	4.6	pKd	=	4.6	Functional	Histamine H1-receptor activity on isolated guinea pig ileumHistamine H1-receptor activity on isolated guinea pig ileum	ChEMBL	273	7	2	4	3.0	CC/C(=N\O)c1ccc(OCCCc2c[nH]cn2)cc1	10.1021/jm000971p
	CHEMBL1185539	12374	0	None	-	0	Guinea pig	4.6	pKd	=	4.6	Functional	Histamine H1-receptor activity on isolated guinea pig ileumHistamine H1-receptor activity on isolated guinea pig ileum	ChEMBL	273	7	2	4	3.0	CC/C(=N\O)c1ccc(OCCCc2c[nH]cn2)cc1	10.1021/jm000971p
	CHEMBL420124	12374	0	None	-	0	Guinea pig	4.6	pKd	=	4.6	Functional	Histamine H1-receptor activity on isolated guinea pig ileumHistamine H1-receptor activity on isolated guinea pig ileum	ChEMBL	273	7	2	4	3.0	CC/C(=N\O)c1ccc(OCCCc2c[nH]cn2)cc1	10.1021/jm000971p
	44274554	83293	0	None	-	0	Guinea pig	7.6	pKd	=	7.6	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	726	17	4	9	7.3	COc1ccc(CN(CCN(C)CCCCCCNC(=O)c2ccc(-c3c4ccc(=N)cc-4oc4cc(N)ccc34)c(C(=O)O)c2)c2ccccn2)cc1	10.1016/s0960-894x(03)00113-6
	CHEMBL21898	83293	0	None	-	0	Guinea pig	7.6	pKd	=	7.6	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	726	17	4	9	7.3	COc1ccc(CN(CCN(C)CCCCCCNC(=O)c2ccc(-c3c4ccc(=N)cc-4oc4cc(N)ccc34)c(C(=O)O)c2)c2ccccn2)cc1	10.1016/s0960-894x(03)00113-6
	44457689	94149	0	None	-	0	Guinea pig	7.6	pKd	=	7.6	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	728	17	3	9	7.3	COc1ccc(CN(CCN(C)CCCCCCNC(=O)c2ccc(C(=O)O)c(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c2)c2ccccn2)cc1	10.1016/s0960-894x(03)00113-6
	CHEMBL24940	94149	0	None	-	0	Guinea pig	7.6	pKd	=	7.6	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	728	17	3	9	7.3	COc1ccc(CN(CCN(C)CCCCCCNC(=O)c2ccc(C(=O)O)c(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c2)c2ccccn2)cc1	10.1016/s0960-894x(03)00113-6
	14660350	199443	0	None	-	0	Guinea pig	6.6	pKd	=	6.6	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	392	10	3	4	2.9	COc1ccc(C(CC/N=C(\N)NCCCc2c[nH]cn2)c2ccccn2)cc1	10.1021/jm00128a045
	CHEMBL59138	199443	0	None	-	0	Guinea pig	6.6	pKd	=	6.6	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	392	10	3	4	2.9	COc1ccc(C(CC/N=C(\N)NCCCc2c[nH]cn2)c2ccccn2)cc1	10.1021/jm00128a045
	164435	204542	32	None	-	0	Guinea pig	4.6	pKd	=	4.6	Functional	Histamine H1 receptor antagonistic activity on the isolated guinea pig ileum determined by Schild plot.Histamine H1 receptor antagonistic activity on the isolated guinea pig ileum determined by Schild plot.	ChEMBL	477	11	4	6	2.5	N#CN/C(=N\CCNC(=O)c1ccc(N)cc1)NCCCOc1cccc(CN2CCCCC2)c1	10.1021/jm00090a013
	CHEMBL72844	204542	32	None	-	0	Guinea pig	4.6	pKd	=	4.6	Functional	Histamine H1 receptor antagonistic activity on the isolated guinea pig ileum determined by Schild plot.Histamine H1 receptor antagonistic activity on the isolated guinea pig ileum determined by Schild plot.	ChEMBL	477	11	4	6	2.5	N#CN/C(=N\CCNC(=O)c1ccc(N)cc1)NCCCOc1cccc(CN2CCCCC2)c1	10.1021/jm00090a013
	3081064	200435	12	None	-	0	Guinea pig	6.6	pKd	=	6.6	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	398	9	4	3	3.4	N=C(NCCCc1c[nH]cn1)NCCC(c1cc(F)cc(F)c1)c1ccccn1	10.1021/jm00128a045
	CHEMBL59832	200435	12	None	-	0	Guinea pig	6.6	pKd	=	6.6	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	398	9	4	3	3.4	N=C(NCCCc1c[nH]cn1)NCCC(c1cc(F)cc(F)c1)c1ccccn1	10.1021/jm00128a045
	14660355	100545	0	None	-	0	Guinea pig	6.6	pKd	=	6.6	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	430	9	4	3	4.1	N=C(NCCCc1c[nH]cn1)NCCC(c1ccc(C(F)(F)F)cc1)c1ccccn1	10.1021/jm00128a045
	CHEMBL291396	100545	0	None	-	0	Guinea pig	6.6	pKd	=	6.6	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	430	9	4	3	4.1	N=C(NCCCc1c[nH]cn1)NCCC(c1ccc(C(F)(F)F)cc1)c1ccccn1	10.1021/jm00128a045
	14660372	199231	0	None	-	0	Guinea pig	6.5	pKd	=	6.5	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	430	9	4	3	4.4	N=C(NCCCc1c[nH]cn1)NCCC(c1ccccn1)c1ccc(Cl)cc1Cl	10.1021/jm00128a045
	CHEMBL58999	199231	0	None	-	0	Guinea pig	6.5	pKd	=	6.5	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	430	9	4	3	4.4	N=C(NCCCc1c[nH]cn1)NCCC(c1ccccn1)c1ccc(Cl)cc1Cl	10.1021/jm00128a045
	11741669	96753	0	None	39	2	Guinea pig	8.5	pKd	=	8.5	Functional	Apparent pA2 value of compound at 10 nM concentration of mepyramine in guinea pig ileumApparent pA2 value of compound at 10 nM concentration of mepyramine in guinea pig ileum	ChEMBL	399	11	3	3	4.3	c1ccc(C(CCc2nc(CCNCCc3cnc[nH]3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
	CHEMBL264491	96753	0	None	39	2	Guinea pig	8.5	pKd	=	8.5	Functional	Apparent pA2 value of compound at 10 nM concentration of mepyramine in guinea pig ileumApparent pA2 value of compound at 10 nM concentration of mepyramine in guinea pig ileum	ChEMBL	399	11	3	3	4.3	c1ccc(C(CCc2nc(CCNCCc3cnc[nH]3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
	11269875	121004	0	None	-	1	Guinea pig	8.5	pKd	=	8.5	Functional	Apparent pA2 value of compound at 10 nM concentration of mepyramine in guinea pig ileumApparent pA2 value of compound at 10 nM concentration of mepyramine in guinea pig ileum	ChEMBL	410	11	2	3	4.9	c1ccc(C(CCc2nc(CCNCCc3cccnc3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
	CHEMBL356449	121004	0	None	-	1	Guinea pig	8.5	pKd	=	8.5	Functional	Apparent pA2 value of compound at 10 nM concentration of mepyramine in guinea pig ileumApparent pA2 value of compound at 10 nM concentration of mepyramine in guinea pig ileum	ChEMBL	410	11	2	3	4.9	c1ccc(C(CCc2nc(CCNCCc3cccnc3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
	44274585	82302	0	None	-	0	Guinea pig	8.5	pKd	=	8.5	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	756	19	3	9	8.1	COc1ccc(CN(CCN(C)CCCCCCCCNC(=O)c2ccc(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c(C(=O)O)c2)c2ccccn2)cc1	10.1016/s0960-894x(03)00113-6
	CHEMBL21721	82302	0	None	-	0	Guinea pig	8.5	pKd	=	8.5	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	756	19	3	9	8.1	COc1ccc(CN(CCN(C)CCCCCCCCNC(=O)c2ccc(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c(C(=O)O)c2)c2ccccn2)cc1	10.1016/s0960-894x(03)00113-6
	25190134	161144	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	404	9	0	5	3.9	CCCCc1cc(OC2CCN(CCS(=O)(=O)CC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4085417	161144	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	404	9	0	5	3.9	CCCCc1cc(OC2CCN(CCS(=O)(=O)CC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4117296	161144	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Antagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR methodAntagonist activity at human histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced intracellular calcium mobilization at 100 nM pretreated for 30 mins followed by histamine addition measured for 1 min by Fluo-4-AM dye based FLIPR method	ChEMBL	404	9	0	5	3.9	CCCCc1cc(OC2CCN(CCS(=O)(=O)CC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	2247	505	81	None	-	42	Guinea pig	8.4	pKd	=	8.4	Functional	Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsAntagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1016/j.bmcl.2011.09.001
	249	505	81	None	-	42	Guinea pig	8.4	pKd	=	8.4	Functional	Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsAntagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1016/j.bmcl.2011.09.001
	2603	505	81	None	-	42	Guinea pig	8.4	pKd	=	8.4	Functional	Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsAntagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1016/j.bmcl.2011.09.001
	CHEMBL296419	505	81	None	-	42	Guinea pig	8.4	pKd	=	8.4	Functional	Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsAntagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1016/j.bmcl.2011.09.001
	DB00637	505	81	None	-	42	Guinea pig	8.4	pKd	=	8.4	Functional	Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsAntagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1016/j.bmcl.2011.09.001
	57393730	67884	0	None	-	0	Guinea pig	8.4	pKd	=	8.4	Functional	Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsAntagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins	ChEMBL	579	8	2	6	5.0	O=C(c1cc2ccccc2[nH]1)N1CCN(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)CC1	10.1016/j.bmcl.2011.09.001
	CHEMBL1910386	67884	0	None	-	0	Guinea pig	8.4	pKd	=	8.4	Functional	Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsAntagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins	ChEMBL	579	8	2	6	5.0	O=C(c1cc2ccccc2[nH]1)N1CCN(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)CC1	10.1016/j.bmcl.2011.09.001
	71456361	80479	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Antagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assayAntagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assay	ChEMBL	369	4	0	6	2.5	CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2nccnc2c1=O	10.1016/j.bmc.2012.08.032
	CHEMBL2146812	80479	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Antagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assayAntagonist activity against human CHO cells H1 receptor at 100 nM after 30 mins by FLIPR assay	ChEMBL	369	4	0	6	2.5	CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2nccnc2c1=O	10.1016/j.bmc.2012.08.032
	24803639	61331	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization at 100 nM after 30 mins by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization at 100 nM after 30 mins by FLIPR assay	ChEMBL	622	14	1	7	6.8	O=c1c2ccccc2c(Cc2ccc(O)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1	10.1021/jm1013874
	CHEMBL1767166	61331	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization at 100 nM after 30 mins by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization at 100 nM after 30 mins by FLIPR assay	ChEMBL	622	14	1	7	6.8	O=c1c2ccccc2c(Cc2ccc(O)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1	10.1021/jm1013874
	13676696	164073	0	None	-	0	Guinea pig	8.4	pKd	=	8.4	Functional	H1-antihistamine activity in guinea pig ileumH1-antihistamine activity in guinea pig ileum	ChEMBL	467	7	1	8	4.0	Cc1c(OCCCN2CCN(Cc3cccc(Cl)c3)CC2)ccc2c(O)c3nnnc-3oc12	10.1021/jm00161a022
	CHEMBL420934	164073	0	None	-	0	Guinea pig	8.4	pKd	=	8.4	Functional	H1-antihistamine activity in guinea pig ileumH1-antihistamine activity in guinea pig ileum	ChEMBL	467	7	1	8	4.0	Cc1c(OCCCN2CCN(Cc3cccc(Cl)c3)CC2)ccc2c(O)c3nnnc-3oc12	10.1021/jm00161a022
	13676697	204794	0	None	-	0	Guinea pig	8.4	pKd	=	8.4	Functional	H1-antihistamine activity in guinea pig ileumH1-antihistamine activity in guinea pig ileum	ChEMBL	467	7	1	8	4.0	Cc1c(OCCCN2CCN(Cc3ccccc3Cl)CC2)ccc2c(O)c3nnnc-3oc12	10.1021/jm00161a022
	CHEMBL74989	204794	0	None	-	0	Guinea pig	8.4	pKd	=	8.4	Functional	H1-antihistamine activity in guinea pig ileumH1-antihistamine activity in guinea pig ileum	ChEMBL	467	7	1	8	4.0	Cc1c(OCCCN2CCN(Cc3ccccc3Cl)CC2)ccc2c(O)c3nnnc-3oc12	10.1021/jm00161a022
	54710795	99897	0	None	-	0	Guinea pig	8.4	pKd	=	8.4	Functional	H1-antihistamine activity on guinea pig ileumH1-antihistamine activity on guinea pig ileum	ChEMBL	531	10	2	9	3.6	CCCc1c(OCC(O)CN2CCN(Cc3ccc(Cl)cc3)CC2)ccc2c(O)c([N+](=O)[O-])c(=O)oc12	10.1021/jm00377a013
	CHEMBL286017	99897	0	None	-	0	Guinea pig	8.4	pKd	=	8.4	Functional	H1-antihistamine activity on guinea pig ileumH1-antihistamine activity on guinea pig ileum	ChEMBL	531	10	2	9	3.6	CCCc1c(OCC(O)CN2CCN(Cc3ccc(Cl)cc3)CC2)ccc2c(O)c([N+](=O)[O-])c(=O)oc12	10.1021/jm00377a013
	42625223	179925	0	None	-	3	Guinea pig	5.5	pKd	=	5.5	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions	ChEMBL	395	8	4	3	1.4	CN(CCC(=O)/N=C(\N)NCCCc1c[nH]cn1)C(=O)c1cc2ccccc2[nH]1	10.1021/jm9000693
	CHEMBL474617	179925	0	None	-	3	Guinea pig	5.5	pKd	=	5.5	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions	ChEMBL	395	8	4	3	1.4	CN(CCC(=O)/N=C(\N)NCCCc1c[nH]cn1)C(=O)c1cc2ccccc2[nH]1	10.1021/jm9000693
	44274584	80684	0	None	-	0	Guinea pig	7.5	pKd	=	7.5	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	700	15	3	9	6.5	COc1ccc(CN(CCN(C)CCCCNC(=O)c2ccc(C(=O)O)c(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c2)c2ccccn2)cc1	10.1016/s0960-894x(03)00113-6
	CHEMBL21514	80684	0	None	-	0	Guinea pig	7.5	pKd	=	7.5	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	700	15	3	9	6.5	COc1ccc(CN(CCN(C)CCCCNC(=O)c2ccc(C(=O)O)c(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c2)c2ccccn2)cc1	10.1016/s0960-894x(03)00113-6
	44274555	77008	0	None	-	0	Guinea pig	7.5	pKd	=	7.5	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	782	18	1	9	6.0	COc1ccc(CN(CCN(C)CCCCCCNC(=O)c2ccc(-c3c4ccc(=[N+](C)C)cc-4oc4cc(N(C)C)ccc34)c(C(=O)[O-])c2)c2ccccn2)cc1	10.1016/s0960-894x(03)00113-6
	CHEMBL20713	77008	0	None	-	0	Guinea pig	7.5	pKd	=	7.5	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	782	18	1	9	6.0	COc1ccc(CN(CCN(C)CCCCCCNC(=O)c2ccc(-c3c4ccc(=[N+](C)C)cc-4oc4cc(N(C)C)ccc34)c(C(=O)[O-])c2)c2ccccn2)cc1	10.1016/s0960-894x(03)00113-6
	14660378	100647	0	None	-	0	Guinea pig	5.5	pKd	=	5.5	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	348	8	4	3	2.7	N=C(NCCCc1c[nH]cn1)NCC(c1ccccc1)c1ccccn1	10.1021/jm00128a045
	CHEMBL292170	100647	0	None	-	0	Guinea pig	5.5	pKd	=	5.5	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	348	8	4	3	2.7	N=C(NCCCc1c[nH]cn1)NCC(c1ccccc1)c1ccccn1	10.1021/jm00128a045
	1226	2019	20	None	-	1	Guinea pig	5.5	pKd	=	5.5	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	10.1021/jm800841w
	41376	2019	20	None	-	1	Guinea pig	5.5	pKd	=	5.5	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	10.1021/jm800841w
	CHEMBL12608	2019	20	None	-	1	Guinea pig	5.5	pKd	=	5.5	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	10.1021/jm800841w
	14660384	202733	0	None	-	0	Guinea pig	7.5	pKd	=	7.5	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	379	9	4	2	3.8	N=C(NCCCc1c[nH]cn1)NCCC(c1ccccc1)c1ccc(F)cc1	10.1021/jm00128a045
	CHEMBL61852	202733	0	None	-	0	Guinea pig	7.5	pKd	=	7.5	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	379	9	4	2	3.8	N=C(NCCCc1c[nH]cn1)NCCC(c1ccccc1)c1ccc(F)cc1	10.1021/jm00128a045
	14660395	202781	0	None	-	0	Guinea pig	6.5	pKd	=	6.5	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	378	8	4	3	3.1	N=C(NC/C=C(\c1ccc(F)cc1)c1ccccn1)NCCCc1c[nH]cn1	10.1021/jm00128a045
	CHEMBL62147	202781	0	None	-	0	Guinea pig	6.5	pKd	=	6.5	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	378	8	4	3	3.1	N=C(NC/C=C(\c1ccc(F)cc1)c1ccccn1)NCCCc1c[nH]cn1	10.1021/jm00128a045
	42625386	178353	0	None	-	4	Guinea pig	5.5	pKd	=	5.5	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions	ChEMBL	237	6	3	2	0.6	CCCC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/jm9000693
	CHEMBL465170	178353	0	None	-	4	Guinea pig	5.5	pKd	=	5.5	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions	ChEMBL	237	6	3	2	0.6	CCCC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/jm9000693
	44274553	82399	0	None	-	0	Guinea pig	7.4	pKd	=	7.4	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	828	17	3	9	9.7	COc1ccc(CN(CCN(C)CCCCCCNC(=O)c2ccc(-c3c4ccc5cc(O)ccc5c4oc4c3ccc3cc(=O)ccc34)c(C(=O)O)c2)c2ccccn2)cc1	10.1016/s0960-894x(03)00113-6
	CHEMBL21727	82399	0	None	-	0	Guinea pig	7.4	pKd	=	7.4	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	828	17	3	9	9.7	COc1ccc(CN(CCN(C)CCCCCCNC(=O)c2ccc(-c3c4ccc5cc(O)ccc5c4oc4c3ccc3cc(=O)ccc34)c(C(=O)O)c2)c2ccccn2)cc1	10.1016/s0960-894x(03)00113-6
	14660382	198660	0	None	-	0	Guinea pig	7.4	pKd	=	7.4	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	380	9	4	3	3.2	N=C(NCCCc1c[nH]cn1)NCCC(c1ccncc1)c1ccc(F)cc1	10.1021/jm00128a045
	CHEMBL57933	198660	0	None	-	0	Guinea pig	7.4	pKd	=	7.4	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	380	9	4	3	3.2	N=C(NCCCc1c[nH]cn1)NCCC(c1ccncc1)c1ccc(F)cc1	10.1021/jm00128a045
	1199	2976	0	None	-	0	Guinea pig	5.4	pKd	=	5.4	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	394	8	3	4	2.5	NC(=NCCCc1[nH]cnc1)NC(=O)CC(c1ccccn1)c1ccc(cc1)F	10.1021/jm800841w
	25149244	2976	0	None	-	0	Guinea pig	5.4	pKd	=	5.4	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	394	8	3	4	2.5	NC(=NCCCc1[nH]cnc1)NC(=O)CC(c1ccccn1)c1ccc(cc1)F	10.1021/jm800841w
	CHEMBL472273	2976	0	None	-	0	Guinea pig	5.4	pKd	=	5.4	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	394	8	3	4	2.5	NC(=NCCCc1[nH]cnc1)NC(=O)CC(c1ccccn1)c1ccc(cc1)F	10.1021/jm800841w
	42626109	179768	0	None	-	2	Guinea pig	7.4	pKd	=	7.4	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions	ChEMBL	324	6	4	2	1.5	N/C(=N\C(=O)Cc1c[nH]c2ccccc12)NCCCc1c[nH]cn1	10.1021/jm9000693
	CHEMBL474447	179768	0	None	-	2	Guinea pig	7.4	pKd	=	7.4	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions	ChEMBL	324	6	4	2	1.5	N/C(=N\C(=O)Cc1c[nH]c2ccccc12)NCCCc1c[nH]cn1	10.1021/jm9000693
	14660376	202568	0	None	-	0	Guinea pig	6.4	pKd	=	6.4	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	363	9	4	4	2.5	N=C(NCCCc1c[nH]cn1)NCCC(c1ccccn1)c1ccccn1	10.1021/jm00128a045
	CHEMBL61185	202568	0	None	-	0	Guinea pig	6.4	pKd	=	6.4	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	363	9	4	4	2.5	N=C(NCCCc1c[nH]cn1)NCCC(c1ccccn1)c1ccccn1	10.1021/jm00128a045
	2861590	107260	7	None	-	1	Guinea pig	7.4	pKd	=	7.4	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	342	5	0	3	3.0	CN(C)CCCN1C(=O)CSC1c1ccc(Br)cc1	10.1021/jm00093a025
	CHEMBL1202937	107260	7	None	-	1	Guinea pig	7.4	pKd	=	7.4	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	342	5	0	3	3.0	CN(C)CCCN1C(=O)CSC1c1ccc(Br)cc1	10.1021/jm00093a025
	CHEMBL316951	107260	7	None	-	1	Guinea pig	7.4	pKd	=	7.4	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	342	5	0	3	3.0	CN(C)CCCN1C(=O)CSC1c1ccc(Br)cc1	10.1021/jm00093a025
	126624	208290	10	None	-	1	Guinea pig	7.4	pKd	=	7.4	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	264	5	0	3	2.2	CN(C)CCCN1C(=O)CSC1c1ccccc1	10.1021/jm00093a025
	CHEMBL1202936	208290	10	None	-	1	Guinea pig	7.4	pKd	=	7.4	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	264	5	0	3	2.2	CN(C)CCCN1C(=O)CSC1c1ccccc1	10.1021/jm00093a025
	CHEMBL98989	208290	10	None	-	1	Guinea pig	7.4	pKd	=	7.4	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	264	5	0	3	2.2	CN(C)CCCN1C(=O)CSC1c1ccccc1	10.1021/jm00093a025
	42625221	189588	0	None	-	2	Guinea pig	6.4	pKd	=	6.4	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions	ChEMBL	338	7	4	2	1.9	N/C(=N\C(=O)CCc1c[nH]c2ccccc12)NCCCc1c[nH]cn1	10.1021/jm9000693
	CHEMBL514641	189588	0	None	-	2	Guinea pig	6.4	pKd	=	6.4	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions	ChEMBL	338	7	4	2	1.9	N/C(=N\C(=O)CCc1c[nH]c2ccccc12)NCCCc1c[nH]cn1	10.1021/jm9000693
	14984033	208178	1	None	-	1	Guinea pig	6.4	pKd	=	6.4	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	294	6	0	4	2.2	COc1cccc(C2SCC(=O)N2CCCN(C)C)c1	10.1021/jm00093a025
	CHEMBL1202941	208178	1	None	-	1	Guinea pig	6.4	pKd	=	6.4	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	294	6	0	4	2.2	COc1cccc(C2SCC(=O)N2CCCN(C)C)c1	10.1021/jm00093a025
	CHEMBL98334	208178	1	None	-	1	Guinea pig	6.4	pKd	=	6.4	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	294	6	0	4	2.2	COc1cccc(C2SCC(=O)N2CCCN(C)C)c1	10.1021/jm00093a025
	14984032	208341	1	None	-	1	Guinea pig	6.4	pKd	=	6.4	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	342	5	0	3	3.0	CN(C)CCCN1C(=O)CSC1c1cccc(Br)c1	10.1021/jm00093a025
	CHEMBL1202932	208341	1	None	-	1	Guinea pig	6.4	pKd	=	6.4	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	342	5	0	3	3.0	CN(C)CCCN1C(=O)CSC1c1cccc(Br)c1	10.1021/jm00093a025
	CHEMBL99350	208341	1	None	-	1	Guinea pig	6.4	pKd	=	6.4	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	342	5	0	3	3.0	CN(C)CCCN1C(=O)CSC1c1cccc(Br)c1	10.1021/jm00093a025
	14984031	208373	1	None	-	1	Guinea pig	6.4	pKd	=	6.4	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	282	5	0	3	2.4	CN(C)CCCN1C(=O)CSC1c1cccc(F)c1	10.1021/jm00093a025
	CHEMBL1202933	208373	1	None	-	1	Guinea pig	6.4	pKd	=	6.4	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	282	5	0	3	2.4	CN(C)CCCN1C(=O)CSC1c1cccc(F)c1	10.1021/jm00093a025
	CHEMBL99529	208373	1	None	-	1	Guinea pig	6.4	pKd	=	6.4	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	282	5	0	3	2.4	CN(C)CCCN1C(=O)CSC1c1cccc(F)c1	10.1021/jm00093a025
	2861786	208177	8	None	-	0	Guinea pig	5.4	pKd	=	5.4	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	309	6	0	5	2.1	CN(C)CCCN1C(=O)CSC1c1cccc([N+](=O)[O-])c1	10.1021/jm00093a025
	CHEMBL1202940	208177	8	None	-	0	Guinea pig	5.4	pKd	=	5.4	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	309	6	0	5	2.1	CN(C)CCCN1C(=O)CSC1c1cccc([N+](=O)[O-])c1	10.1021/jm00093a025
	CHEMBL98333	208177	8	None	-	0	Guinea pig	5.4	pKd	=	5.4	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	309	6	0	5	2.1	CN(C)CCCN1C(=O)CSC1c1cccc([N+](=O)[O-])c1	10.1021/jm00093a025
	10364258	45769	0	None	12	2	Guinea pig	8.4	pKd	=	8.4	Functional	Apparent pA2 value of compound at 10 nM concentration of mepyramine in guinea pig ileumApparent pA2 value of compound at 10 nM concentration of mepyramine in guinea pig ileum	ChEMBL	410	11	2	3	4.9	c1ccc(C(CCc2nc(CCNCCc3ccccn3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
	CHEMBL153067	45769	0	None	12	2	Guinea pig	8.4	pKd	=	8.4	Functional	Apparent pA2 value of compound at 10 nM concentration of mepyramine in guinea pig ileumApparent pA2 value of compound at 10 nM concentration of mepyramine in guinea pig ileum	ChEMBL	410	11	2	3	4.9	c1ccc(C(CCc2nc(CCNCCc3ccccn3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
	44274569	80841	0	None	-	0	Guinea pig	8.4	pKd	=	8.4	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	700	15	3	9	6.5	COc1ccc(CN(CCN(C)CCCCNC(=O)c2ccc(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c(C(=O)O)c2)c2ccccn2)cc1	10.1016/s0960-894x(03)00113-6
	CHEMBL21525	80841	0	None	-	0	Guinea pig	8.4	pKd	=	8.4	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	700	15	3	9	6.5	COc1ccc(CN(CCN(C)CCCCNC(=O)c2ccc(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c(C(=O)O)c2)c2ccccn2)cc1	10.1016/s0960-894x(03)00113-6
	44274548	99186	0	None	-	0	Guinea pig	8.3	pKd	=	8.3	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	477	12	1	10	3.6	COc1ccc(CN(CCN(C)CCNc2ccc([N+](=O)[O-])c3nonc23)c2ccccn2)cc1	10.1016/s0960-894x(03)00113-6
	CHEMBL281365	99186	0	None	-	0	Guinea pig	8.3	pKd	=	8.3	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	477	12	1	10	3.6	COc1ccc(CN(CCN(C)CCNc2ccc([N+](=O)[O-])c3nonc23)c2ccccn2)cc1	10.1016/s0960-894x(03)00113-6
	57402472	67879	0	None	-	0	Guinea pig	8.3	pKd	=	8.3	Functional	Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsAntagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins	ChEMBL	526	11	1	6	4.0	COc1ccc(CN(CCN(C)CCN2CCN(C(=O)c3cc4ccccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
	CHEMBL1910381	67879	0	None	-	0	Guinea pig	8.3	pKd	=	8.3	Functional	Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsAntagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins	ChEMBL	526	11	1	6	4.0	COc1ccc(CN(CCN(C)CCN2CCN(C(=O)c3cc4ccccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
	1200	3963	2	None	-	0	Guinea pig	5.4	pKd	=	5.4	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	335	8	4	5	0.7	O=C(NC(=NCCCc1cnc[nH]1)N)CSCc1nc[nH]c1C	10.1021/jm800841w
	25149519	3963	2	None	-	0	Guinea pig	5.4	pKd	=	5.4	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	335	8	4	5	0.7	O=C(NC(=NCCCc1cnc[nH]1)N)CSCc1nc[nH]c1C	10.1021/jm800841w
	CHEMBL513056	3963	2	None	-	0	Guinea pig	5.4	pKd	=	5.4	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	335	8	4	5	0.7	O=C(NC(=NCCCc1cnc[nH]1)N)CSCc1nc[nH]c1C	10.1021/jm800841w
	14660370	163245	0	None	-	0	Guinea pig	7.4	pKd	=	7.4	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	430	9	4	3	4.4	N=C(NCCCc1c[nH]cn1)NCCC(c1cc(Cl)cc(Cl)c1)c1ccccn1	10.1021/jm00128a045
	CHEMBL418508	163245	0	None	-	0	Guinea pig	7.4	pKd	=	7.4	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	430	9	4	3	4.4	N=C(NCCCc1c[nH]cn1)NCCC(c1cc(Cl)cc(Cl)c1)c1ccccn1	10.1021/jm00128a045
	14660363	202678	0	None	-	0	Guinea pig	6.4	pKd	=	6.4	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	380	9	4	3	3.2	N=C(NCCCc1c[nH]cn1)NCCC(c1ccccn1)c1ccccc1F	10.1021/jm00128a045
	CHEMBL61523	202678	0	None	-	0	Guinea pig	6.4	pKd	=	6.4	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	380	9	4	3	3.2	N=C(NCCCc1c[nH]cn1)NCCC(c1ccccn1)c1ccccc1F	10.1021/jm00128a045
	14660411	199714	0	None	-	0	Guinea pig	7.3	pKd	=	7.3	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	368	9	4	4	3.1	N=C(NCCCc1c[nH]cn1)NCCC(c1ccccn1)c1cccs1	10.1021/jm00128a045
	CHEMBL59339	199714	0	None	-	0	Guinea pig	7.3	pKd	=	7.3	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	368	9	4	4	3.1	N=C(NCCCc1c[nH]cn1)NCCC(c1ccccn1)c1cccs1	10.1021/jm00128a045
	14660345	199093	0	None	-	0	Guinea pig	7.3	pKd	=	7.3	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	394	10	4	3	3.6	N=C(NCCCc1c[nH]cn1)NCCCC(c1ccc(F)cc1)c1ccccn1	10.1021/jm00128a045
	CHEMBL58869	199093	0	None	-	0	Guinea pig	7.3	pKd	=	7.3	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	394	10	4	3	3.6	N=C(NCCCc1c[nH]cn1)NCCCC(c1ccc(F)cc1)c1ccccn1	10.1021/jm00128a045
	25149613	179200	0	None	-	2	Guinea pig	5.3	pKd	=	5.3	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	382	8	4	5	2.7	N=C(NCCCc1c[nH]cn1)NC(=O)CC(c1ccccc1)c1nccs1	10.1021/jm800841w
	CHEMBL472441	179200	0	None	-	2	Guinea pig	5.3	pKd	=	5.3	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	382	8	4	5	2.7	N=C(NCCCc1c[nH]cn1)NC(=O)CC(c1ccccc1)c1nccs1	10.1021/jm800841w
	25149246	189476	0	None	-	0	Guinea pig	5.3	pKd	=	5.3	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	418	8	4	5	2.9	N=C(NCCCc1c[nH]cn1)NC(=O)CC(c1ccc(F)c(F)c1)c1nccs1	10.1021/jm800841w
	CHEMBL513755	189476	0	None	-	0	Guinea pig	5.3	pKd	=	5.3	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	418	8	4	5	2.9	N=C(NCCCc1c[nH]cn1)NC(=O)CC(c1ccc(F)c(F)c1)c1nccs1	10.1021/jm800841w
	54587323	63116	0	None	-	1	Guinea pig	4.3	pKd	=	4.3	Functional	Antagonist activity at histamine H1 receptor in guinea-pig ileumAntagonist activity at histamine H1 receptor in guinea-pig ileum	ChEMBL	277	7	2	3	3.0	O=C(NCCC1=CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
	CHEMBL1774596	63116	0	None	-	1	Guinea pig	4.3	pKd	=	4.3	Functional	Antagonist activity at histamine H1 receptor in guinea-pig ileumAntagonist activity at histamine H1 receptor in guinea-pig ileum	ChEMBL	277	7	2	3	3.0	O=C(NCCC1=CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
	CHEMBL1789341	63116	0	None	-	1	Guinea pig	4.3	pKd	=	4.3	Functional	Antagonist activity at histamine H1 receptor in guinea-pig ileumAntagonist activity at histamine H1 receptor in guinea-pig ileum	ChEMBL	277	7	2	3	3.0	O=C(NCCC1=CCCCC1)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
	134136763	142848	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux at 100 nM preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux at 100 nM preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	500	11	0	5	6.0	c1cnc2c(N3CCN(CCCCc4ccc(OCCCN5CCCCCC5)cc4)CC3)cccc2c1	10.1016/j.bmcl.2016.11.022
	CHEMBL3893197	142848	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux at 100 nM preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux at 100 nM preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	500	11	0	5	6.0	c1cnc2c(N3CCN(CCCCc4ccc(OCCCN5CCCCCC5)cc4)CC3)cccc2c1	10.1016/j.bmcl.2016.11.022
	54710793	108821	0	None	-	0	Guinea pig	8.3	pKd	=	8.3	Functional	H1-antihistamine activity on guinea pig ileumH1-antihistamine activity on guinea pig ileum	ChEMBL	489	8	2	9	2.6	O=c1oc2cc(OCC(O)CN3CCN(Cc4ccc(Cl)cc4)CC3)ccc2c(O)c1[N+](=O)[O-]	10.1021/jm00377a013
	CHEMBL32097	108821	0	None	-	0	Guinea pig	8.3	pKd	=	8.3	Functional	H1-antihistamine activity on guinea pig ileumH1-antihistamine activity on guinea pig ileum	ChEMBL	489	8	2	9	2.6	O=c1oc2cc(OCC(O)CN3CCN(Cc4ccc(Cl)cc4)CC3)ccc2c(O)c1[N+](=O)[O-]	10.1021/jm00377a013
	44274583	98727	0	None	-	0	Guinea pig	8.3	pKd	=	8.3	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	756	19	3	9	8.1	COc1ccc(CN(CCN(C)CCCCCCCCNC(=O)c2ccc(C(=O)O)c(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c2)c2ccccn2)cc1	10.1016/s0960-894x(03)00113-6
	CHEMBL277850	98727	0	None	-	0	Guinea pig	8.3	pKd	=	8.3	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	756	19	3	9	8.1	COc1ccc(CN(CCN(C)CCCCCCCCNC(=O)c2ccc(C(=O)O)c(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c2)c2ccccn2)cc1	10.1016/s0960-894x(03)00113-6
	4440380	4255	3	None	-	1	Guinea pig	8.3	pKd	=	8.3	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	278	5	0	3	2.5	Cc1ccc(C2SCC(=O)N2CCCN(C)C)cc1	10.1021/jm00093a025
	CHEMBL100487	4255	3	None	-	1	Guinea pig	8.3	pKd	=	8.3	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	278	5	0	3	2.5	Cc1ccc(C2SCC(=O)N2CCCN(C)C)cc1	10.1021/jm00093a025
	CHEMBL1202938	4255	3	None	-	1	Guinea pig	8.3	pKd	=	8.3	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	278	5	0	3	2.5	Cc1ccc(C2SCC(=O)N2CCCN(C)C)cc1	10.1021/jm00093a025
	11791817	98303	0	None	-1	2	Guinea pig	8.2	pKd	=	8.2	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (relaxation) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig aorta (relaxation) at a mepyramine concentration of 100 nM	ChEMBL	345	9	2	2	4.5	c1ccc(C(CCc2nc(CCNC3CC3)c[nH]2)c2ccccc2)cc1	10.1021/jm991056a
	CHEMBL274831	98303	0	None	-1	2	Guinea pig	8.2	pKd	=	8.2	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (relaxation) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig aorta (relaxation) at a mepyramine concentration of 100 nM	ChEMBL	345	9	2	2	4.5	c1ccc(C(CCc2nc(CCNC3CC3)c[nH]2)c2ccccc2)cc1	10.1021/jm991056a
	10083274	11394	0	None	-	0	Guinea pig	4.3	pKd	=	4.3	Functional	Histamine H1-receptor activity on isolated guinea pig ileumHistamine H1-receptor activity on isolated guinea pig ileum	ChEMBL	246	6	2	3	2.5	CC(O)c1ccc(OCCCc2c[nH]cn2)cc1	10.1021/jm000971p
	CHEMBL112676	11394	0	None	-	0	Guinea pig	4.3	pKd	=	4.3	Functional	Histamine H1-receptor activity on isolated guinea pig ileumHistamine H1-receptor activity on isolated guinea pig ileum	ChEMBL	246	6	2	3	2.5	CC(O)c1ccc(OCCCc2c[nH]cn2)cc1	10.1021/jm000971p
	CHEMBL1180069	11394	0	None	-	0	Guinea pig	4.3	pKd	=	4.3	Functional	Histamine H1-receptor activity on isolated guinea pig ileumHistamine H1-receptor activity on isolated guinea pig ileum	ChEMBL	246	6	2	3	2.5	CC(O)c1ccc(OCCCc2c[nH]cn2)cc1	10.1021/jm000971p
	14660365	199987	0	None	-	0	Guinea pig	6.3	pKd	=	6.3	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	396	9	4	3	3.7	N=C(NCCCc1c[nH]cn1)NCCC(c1ccccn1)c1ccccc1Cl	10.1021/jm00128a045
	CHEMBL59521	199987	0	None	-	0	Guinea pig	6.3	pKd	=	6.3	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	396	9	4	3	3.7	N=C(NCCCc1c[nH]cn1)NCCC(c1ccccn1)c1ccccc1Cl	10.1021/jm00128a045
	42625303	180766	0	None	-	6	Guinea pig	5.3	pKd	=	5.3	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions	ChEMBL	223	5	3	2	0.2	CCC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/jm9000693
	CHEMBL475621	180766	0	None	-	6	Guinea pig	5.3	pKd	=	5.3	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions	ChEMBL	223	5	3	2	0.2	CCC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/jm9000693
	25149431	185437	0	None	-	0	Guinea pig	5.3	pKd	=	5.3	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	277	5	4	3	1.6	N=C(NCCCc1c[nH]cn1)NC(=O)C1CCCCC1	10.1021/jm800841w
	CHEMBL486153	185437	0	None	-	0	Guinea pig	5.3	pKd	=	5.3	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	277	5	4	3	1.6	N=C(NCCCc1c[nH]cn1)NC(=O)C1CCCCC1	10.1021/jm800841w
	14660361	201502	0	None	-	0	Guinea pig	6.3	pKd	=	6.3	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	430	9	4	3	4.1	N=C(NCCCc1c[nH]cn1)NCCC(c1cccc(C(F)(F)F)c1)c1ccccn1	10.1021/jm00128a045
	CHEMBL60515	201502	0	None	-	0	Guinea pig	6.3	pKd	=	6.3	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	430	9	4	3	4.1	N=C(NCCCc1c[nH]cn1)NCCC(c1cccc(C(F)(F)F)c1)c1ccccn1	10.1021/jm00128a045
	25149811	185962	0	None	-	0	Guinea pig	6.3	pKd	=	6.3	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	327	9	4	3	2.4	N=C(NCCCc1c[nH]cn1)NC(=O)CCCCc1ccccc1	10.1021/jm800841w
	CHEMBL486963	185962	0	None	-	0	Guinea pig	6.3	pKd	=	6.3	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	327	9	4	3	2.4	N=C(NCCCc1c[nH]cn1)NC(=O)CCCCc1ccccc1	10.1021/jm800841w
	25149425	188206	0	None	-	0	Guinea pig	6.2	pKd	=	6.2	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	285	6	4	3	1.2	N=C(NCCCc1c[nH]cn1)NC(=O)Cc1ccccc1	10.1021/jm800841w
	CHEMBL499092	188206	0	None	-	0	Guinea pig	6.2	pKd	=	6.2	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	285	6	4	3	1.2	N=C(NCCCc1c[nH]cn1)NC(=O)Cc1ccccc1	10.1021/jm800841w
	10410901	119747	0	None	-23	2	Rat	8.2	pKd	=	8.2	Functional	Apparent pA2 value of compound at 50 nM concentration of mepyramine in rat aortaApparent pA2 value of compound at 50 nM concentration of mepyramine in rat aorta	ChEMBL	438	13	2	3	5.7	c1ccc(C(CCc2nc(CCNCCCCc3ccccn3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
	CHEMBL347796	119747	0	None	-23	2	Rat	8.2	pKd	=	8.2	Functional	Apparent pA2 value of compound at 50 nM concentration of mepyramine in rat aortaApparent pA2 value of compound at 50 nM concentration of mepyramine in rat aorta	ChEMBL	438	13	2	3	5.7	c1ccc(C(CCc2nc(CCNCCCCc3ccccn3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
	23582308	145864	0	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux at 100 nM preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux at 100 nM preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	634	14	1	6	6.9	O=C(O)CCc1ccc2cc(Cc3ccccc3)cc(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)c2n1	10.1016/j.bmcl.2016.11.022
	CHEMBL3917428	145864	0	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux at 100 nM preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux at 100 nM preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	634	14	1	6	6.9	O=C(O)CCc1ccc2cc(Cc3ccccc3)cc(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)c2n1	10.1016/j.bmcl.2016.11.022
	153224	202827	27	None	-	0	Guinea pig	8.2	pKd	=	8.2	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	271	7	1	4	2.3	CNCCN(Cc1ccc(OC)cc1)c1ccccn1	10.1016/s0960-894x(03)00113-6
	CHEMBL624	202827	27	None	-	0	Guinea pig	8.2	pKd	=	8.2	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	271	7	1	4	2.3	CNCCN(Cc1ccc(OC)cc1)c1ccccn1	10.1016/s0960-894x(03)00113-6
	25149433	185976	3	None	-	0	Guinea pig	5.2	pKd	=	5.2	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	305	7	4	3	2.3	N=C(NCCCc1c[nH]cn1)NC(=O)CCC1CCCCC1	10.1021/jm800841w
	CHEMBL486974	185976	3	None	-	0	Guinea pig	5.2	pKd	=	5.2	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	305	7	4	3	2.3	N=C(NCCCc1c[nH]cn1)NC(=O)CCC1CCCCC1	10.1021/jm800841w
	13676693	103001	0	None	-	0	Guinea pig	7.2	pKd	=	7.2	Functional	Compound was tested for H1-antihistamine activity in guinea pig ileum.Compound was tested for H1-antihistamine activity in guinea pig ileum.	ChEMBL	463	8	1	9	3.3	COc1ccc(CN2CCN(CCCOc3ccc4c(O)c5nnnc-5oc4c3C)CC2)cc1	10.1021/jm00161a022
	CHEMBL306807	103001	0	None	-	0	Guinea pig	7.2	pKd	=	7.2	Functional	Compound was tested for H1-antihistamine activity in guinea pig ileum.Compound was tested for H1-antihistamine activity in guinea pig ileum.	ChEMBL	463	8	1	9	3.3	COc1ccc(CN2CCN(CCCOc3ccc4c(O)c5nnnc-5oc4c3C)CC2)cc1	10.1021/jm00161a022
	2860026	108376	7	None	-	1	Guinea pig	6.2	pKd	=	6.2	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	298	5	0	3	2.9	CN(C)CCCN1C(=O)CSC1c1cccc(Cl)c1	10.1021/jm00093a025
	CHEMBL319829	108376	7	None	-	1	Guinea pig	6.2	pKd	=	6.2	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	298	5	0	3	2.9	CN(C)CCCN1C(=O)CSC1c1cccc(Cl)c1	10.1021/jm00093a025
	2861042	111583	8	None	-	0	Guinea pig	5.2	pKd	=	5.2	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	309	6	0	5	2.1	CN(C)CCCN1C(=O)CSC1c1ccc([N+](=O)[O-])cc1	10.1021/jm00093a025
	CHEMBL1202943	111583	8	None	-	0	Guinea pig	5.2	pKd	=	5.2	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	309	6	0	5	2.1	CN(C)CCCN1C(=O)CSC1c1ccc([N+](=O)[O-])cc1	10.1021/jm00093a025
	CHEMBL328201	111583	8	None	-	0	Guinea pig	5.2	pKd	=	5.2	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	309	6	0	5	2.1	CN(C)CCCN1C(=O)CSC1c1ccc([N+](=O)[O-])cc1	10.1021/jm00093a025
	11356502	11338	0	None	-	0	Guinea pig	4.2	pKd	=	4.2	Functional	Functional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileumFunctional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileum	ChEMBL	222	6	1	2	3.3	c1nc(COCCCC2CCCCC2)c[nH]1	10.1021/jm031065q
	CHEMBL1179596	11338	0	None	-	0	Guinea pig	4.2	pKd	=	4.2	Functional	Functional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileumFunctional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileum	ChEMBL	222	6	1	2	3.3	c1nc(COCCCC2CCCCC2)c[nH]1	10.1021/jm031065q
	CHEMBL88362	11338	0	None	-	0	Guinea pig	4.2	pKd	=	4.2	Functional	Functional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileumFunctional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileum	ChEMBL	222	6	1	2	3.3	c1nc(COCCCC2CCCCC2)c[nH]1	10.1021/jm031065q
	14660412	202206	0	None	-	0	Guinea pig	6.2	pKd	=	6.2	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pigAntagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig	ChEMBL	378	9	4	4	2.6	N/C(=N\CCC(c1ccc(O)cc1)c1ccccn1)NCCCc1c[nH]cn1	10.1021/jm00128a045
	CHEMBL60972	202206	0	None	-	0	Guinea pig	6.2	pKd	=	6.2	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pigAntagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig	ChEMBL	378	9	4	4	2.6	N/C(=N\CCC(c1ccc(O)cc1)c1ccccn1)NCCCc1c[nH]cn1	10.1021/jm00128a045
	44457674	84311	0	None	-	0	Guinea pig	7.2	pKd	=	7.2	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	672	13	3	9	5.7	COc1ccc(CN(CCN(C)CCNC(=O)c2ccc(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c(C(=O)O)c2)c2ccccn2)cc1	10.1016/s0960-894x(03)00113-6
	CHEMBL22152	84311	0	None	-	0	Guinea pig	7.2	pKd	=	7.2	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	672	13	3	9	5.7	COc1ccc(CN(CCN(C)CCNC(=O)c2ccc(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c(C(=O)O)c2)c2ccccn2)cc1	10.1016/s0960-894x(03)00113-6
	57391869	63120	0	None	-	1	Guinea pig	4.2	pKd	=	4.2	Functional	Antagonist activity at histamine H1 receptor in guinea-pig ileumAntagonist activity at histamine H1 receptor in guinea-pig ileum	ChEMBL	223	6	2	3	1.6	CC=CCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
	CHEMBL1774589	63120	0	None	-	1	Guinea pig	4.2	pKd	=	4.2	Functional	Antagonist activity at histamine H1 receptor in guinea-pig ileumAntagonist activity at histamine H1 receptor in guinea-pig ileum	ChEMBL	223	6	2	3	1.6	CC=CCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
	CHEMBL1789349	63120	0	None	-	1	Guinea pig	4.2	pKd	=	4.2	Functional	Antagonist activity at histamine H1 receptor in guinea-pig ileumAntagonist activity at histamine H1 receptor in guinea-pig ileum	ChEMBL	223	6	2	3	1.6	CC=CCNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
	57400700	67878	0	None	-	0	Guinea pig	8.1	pKd	=	8.1	Functional	Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsAntagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins	ChEMBL	470	8	1	6	3.4	COc1ccc(CN(CCN2CCN(C(=O)c3nc4ccccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
	CHEMBL1910380	67878	0	None	-	0	Guinea pig	8.1	pKd	=	8.1	Functional	Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsAntagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins	ChEMBL	470	8	1	6	3.4	COc1ccc(CN(CCN2CCN(C(=O)c3nc4ccccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
	57397301	67880	0	None	-	0	Guinea pig	8.1	pKd	=	8.1	Functional	Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsAntagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins	ChEMBL	560	11	1	6	4.6	COc1ccc(CN(CCN(C)CCN2CCN(C(=O)c3cc4cc(Cl)ccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
	CHEMBL1910382	67880	0	None	-	0	Guinea pig	8.1	pKd	=	8.1	Functional	Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsAntagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins	ChEMBL	560	11	1	6	4.6	COc1ccc(CN(CCN(C)CCN2CCN(C(=O)c3cc4cc(Cl)ccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
	145961372	161607	0	None	-	1	Guinea pig	6.2	pKd	=	6.2	Functional	Antagonist potency at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions at 0.3 to 3 uM after 15 minsAntagonist potency at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions at 0.3 to 3 uM after 15 mins	ChEMBL	311	7	0	2	5.3	c1ccc2c(OCCCCCN3CCCCCC3)cccc2c1	10.1016/j.bmc.2018.04.023
	CHEMBL4129589	161607	0	None	-	1	Guinea pig	6.2	pKd	=	6.2	Functional	Antagonist potency at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions at 0.3 to 3 uM after 15 minsAntagonist potency at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions at 0.3 to 3 uM after 15 mins	ChEMBL	311	7	0	2	5.3	c1ccc2c(OCCCCCN3CCCCCC3)cccc2c1	10.1016/j.bmc.2018.04.023
	2200	20203	61	None	-	12	Guinea pig	7.1	pKd	=	7.1	Functional	Antagonist potency at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions after 15 minsAntagonist potency at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions after 15 mins	ChEMBL	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	10.1016/j.bmc.2018.04.023
	CHEMBL1256819	20203	61	None	-	12	Guinea pig	7.1	pKd	=	7.1	Functional	Antagonist potency at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions after 15 minsAntagonist potency at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions after 15 mins	ChEMBL	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	10.1016/j.bmc.2018.04.023
	CHEMBL1305	20203	61	None	-	12	Guinea pig	7.1	pKd	=	7.1	Functional	Antagonist potency at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions after 15 minsAntagonist potency at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions after 15 mins	ChEMBL	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	10.1016/j.bmc.2018.04.023
	42625224	180764	0	None	-	1	Guinea pig	6.1	pKd	=	6.1	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions	ChEMBL	395	9	5	3	1.5	N/C(=N\C(=O)CCCNC(=O)c1cc2ccccc2[nH]1)NCCCc1c[nH]cn1	10.1021/jm9000693
	CHEMBL475620	180764	0	None	-	1	Guinea pig	6.1	pKd	=	6.1	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions	ChEMBL	395	9	5	3	1.5	N/C(=N\C(=O)CCCNC(=O)c1cc2ccccc2[nH]1)NCCCc1c[nH]cn1	10.1021/jm9000693
	25149521	179052	0	None	-	2	Guinea pig	6.1	pKd	=	6.1	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	375	8	4	3	3.2	N=C(NCCCc1c[nH]cn1)NC(=O)CC(c1ccccc1)c1ccccc1	10.1021/jm800841w
	CHEMBL471413	179052	0	None	-	2	Guinea pig	6.1	pKd	=	6.1	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	375	8	4	3	3.2	N=C(NCCCc1c[nH]cn1)NC(=O)CC(c1ccccc1)c1ccccc1	10.1021/jm800841w
	25149515	185830	0	None	-	0	Guinea pig	6.1	pKd	=	6.1	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	319	8	4	3	2.7	N=C(NCCCc1c[nH]cn1)NC(=O)CCCC1CCCCC1	10.1021/jm800841w
	CHEMBL486746	185830	0	None	-	0	Guinea pig	6.1	pKd	=	6.1	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	319	8	4	3	2.7	N=C(NCCCc1c[nH]cn1)NC(=O)CCCC1CCCCC1	10.1021/jm800841w
	1219	737	0	None	-	0	Guinea pig	7.1	pKd	=	7.1	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	396	9	3	3	3.5	NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)Cl	10.1021/jm00128a045
	14660352	737	0	None	-	0	Guinea pig	7.1	pKd	=	7.1	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	396	9	3	3	3.5	NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)Cl	10.1021/jm00128a045
	CHEMBL304239	737	0	None	-	0	Guinea pig	7.1	pKd	=	7.1	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	396	9	3	3	3.5	NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)Cl	10.1021/jm00128a045
	42625304	179100	0	None	-	4	Guinea pig	5.1	pKd	=	5.1	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions	ChEMBL	237	5	3	2	0.4	CC(C)C(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/jm9000693
	CHEMBL471724	179100	0	None	-	4	Guinea pig	5.1	pKd	=	5.1	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions	ChEMBL	237	5	3	2	0.4	CC(C)C(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/jm9000693
	10094258	199070	0	None	-	0	Guinea pig	7.1	pKd	=	7.1	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	430	9	4	3	4.4	N=C(NCCCc1c[nH]cn1)NCCC(c1ccc(Cl)c(Cl)c1)c1ccccn1	10.1021/jm00128a045
	CHEMBL58740	199070	0	None	-	0	Guinea pig	7.1	pKd	=	7.1	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	430	9	4	3	4.4	N=C(NCCCc1c[nH]cn1)NCCC(c1ccc(Cl)c(Cl)c1)c1ccccn1	10.1021/jm00128a045
	13676703	204605	0	None	-	0	Guinea pig	7.1	pKd	=	7.1	Functional	Compound was tested for H1-antihistamine activity in guinea pig ileum.Compound was tested for H1-antihistamine activity in guinea pig ileum.	ChEMBL	469	10	1	8	4.2	Cc1c(OCCCN(C)CCN(C)Cc2ccc(Cl)cc2)ccc2c(O)c3nnnc-3oc12	10.1021/jm00161a022
	CHEMBL73265	204605	0	None	-	0	Guinea pig	7.1	pKd	=	7.1	Functional	Compound was tested for H1-antihistamine activity in guinea pig ileum.Compound was tested for H1-antihistamine activity in guinea pig ileum.	ChEMBL	469	10	1	8	4.2	Cc1c(OCCCN(C)CCN(C)Cc2ccc(Cl)cc2)ccc2c(O)c3nnnc-3oc12	10.1021/jm00161a022
	2872050	208226	3	None	-	1	Guinea pig	7.1	pKd	=	7.1	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	282	5	0	3	2.4	CN(C)CCCN1C(=O)CSC1c1ccc(F)cc1	10.1021/jm00093a025
	CHEMBL1202939	208226	3	None	-	1	Guinea pig	7.1	pKd	=	7.1	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	282	5	0	3	2.4	CN(C)CCCN1C(=O)CSC1c1ccc(F)cc1	10.1021/jm00093a025
	CHEMBL98605	208226	3	None	-	1	Guinea pig	7.1	pKd	=	7.1	Functional	In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileumIn vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum	ChEMBL	282	5	0	3	2.4	CN(C)CCCN1C(=O)CSC1c1ccc(F)cc1	10.1021/jm00093a025
	11345716	11344	0	None	-	0	Guinea pig	5.1	pKd	=	5.1	Functional	Functional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileumFunctional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileum	ChEMBL	250	8	1	2	3.7	c1nc(CCCOCCCC2CCCCC2)c[nH]1	10.1021/jm031065q
	CHEMBL1179627	11344	0	None	-	0	Guinea pig	5.1	pKd	=	5.1	Functional	Functional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileumFunctional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileum	ChEMBL	250	8	1	2	3.7	c1nc(CCCOCCCC2CCCCC2)c[nH]1	10.1021/jm031065q
	CHEMBL89999	11344	0	None	-	0	Guinea pig	5.1	pKd	=	5.1	Functional	Functional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileumFunctional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileum	ChEMBL	250	8	1	2	3.7	c1nc(CCCOCCCC2CCCCC2)c[nH]1	10.1021/jm031065q
	11413171	12110	0	None	-	1	Guinea pig	5.1	pKd	=	5.1	Functional	Functional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileumFunctional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileum	ChEMBL	210	9	1	2	2.9	CCCCCCOCCCc1c[nH]cn1	10.1021/jm031065q
	CHEMBL1184057	12110	0	None	-	1	Guinea pig	5.1	pKd	=	5.1	Functional	Functional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileumFunctional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileum	ChEMBL	210	9	1	2	2.9	CCCCCCOCCCc1c[nH]cn1	10.1021/jm031065q
	CHEMBL330688	12110	0	None	-	1	Guinea pig	5.1	pKd	=	5.1	Functional	Functional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileumFunctional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileum	ChEMBL	210	9	1	2	2.9	CCCCCCOCCCc1c[nH]cn1	10.1021/jm031065q
	54584376	63168	0	None	-	1	Guinea pig	4.1	pKd	=	4.1	Functional	Antagonist activity at histamine H1 receptor in guinea-pig ileumAntagonist activity at histamine H1 receptor in guinea-pig ileum	ChEMBL	237	7	2	3	2.0	CC/C=C\CNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
	CHEMBL1774592	63168	0	None	-	1	Guinea pig	4.1	pKd	=	4.1	Functional	Antagonist activity at histamine H1 receptor in guinea-pig ileumAntagonist activity at histamine H1 receptor in guinea-pig ileum	ChEMBL	237	7	2	3	2.0	CC/C=C\CNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
	CHEMBL1789809	63168	0	None	-	1	Guinea pig	4.1	pKd	=	4.1	Functional	Antagonist activity at histamine H1 receptor in guinea-pig ileumAntagonist activity at histamine H1 receptor in guinea-pig ileum	ChEMBL	237	7	2	3	2.0	CC/C=C\CNC(=O)OCCCc1c[nH]cn1	10.1016/j.bmc.2011.03.046
	10635074	11404	0	None	-	0	Guinea pig	4.1	pKd	=	4.1	Functional	Histamine H1-receptor activity on isolated guinea pig ileumHistamine H1-receptor activity on isolated guinea pig ileum	ChEMBL	260	6	3	4	1.0	NNC(=O)c1ccc(OCCCc2c[nH]cn2)cc1	10.1021/jm000971p
	CHEMBL113404	11404	0	None	-	0	Guinea pig	4.1	pKd	=	4.1	Functional	Histamine H1-receptor activity on isolated guinea pig ileumHistamine H1-receptor activity on isolated guinea pig ileum	ChEMBL	260	6	3	4	1.0	NNC(=O)c1ccc(OCCCc2c[nH]cn2)cc1	10.1021/jm000971p
	CHEMBL1180094	11404	0	None	-	0	Guinea pig	4.1	pKd	=	4.1	Functional	Histamine H1-receptor activity on isolated guinea pig ileumHistamine H1-receptor activity on isolated guinea pig ileum	ChEMBL	260	6	3	4	1.0	NNC(=O)c1ccc(OCCCc2c[nH]cn2)cc1	10.1021/jm000971p
	57390225	67882	0	None	-	0	Guinea pig	8.1	pKd	=	8.1	Functional	Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsAntagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins	ChEMBL	469	9	2	5	4.1	COc1ccc(CN(CCN[C@H]2CCN(C(=O)c3cc4ccccc4[nH]3)C2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
	CHEMBL1910384	67882	0	None	-	0	Guinea pig	8.1	pKd	=	8.1	Functional	Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsAntagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins	ChEMBL	469	9	2	5	4.1	COc1ccc(CN(CCN[C@H]2CCN(C(=O)c3cc4ccccc4[nH]3)C2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
	10246247	98293	0	None	-	0	Guinea pig	6.1	pKd	=	6.1	Functional	Relative potency was recorded in endothelium-denuded guinea pig(pre contracted with PGF-2 alpha); value ranges from 5.76 to 6.40Relative potency was recorded in endothelium-denuded guinea pig(pre contracted with PGF-2 alpha); value ranges from 5.76 to 6.40	ChEMBL	333	9	2	2	4.5	NCCc1c[nH]c(CCCCC(c2ccccc2)c2ccccc2)n1	10.1021/jm991056a
	CHEMBL274767	98293	0	None	-	0	Guinea pig	6.1	pKd	=	6.1	Functional	Relative potency was recorded in endothelium-denuded guinea pig(pre contracted with PGF-2 alpha); value ranges from 5.76 to 6.40Relative potency was recorded in endothelium-denuded guinea pig(pre contracted with PGF-2 alpha); value ranges from 5.76 to 6.40	ChEMBL	333	9	2	2	4.5	NCCc1c[nH]c(CCCCC(c2ccccc2)c2ccccc2)n1	10.1021/jm991056a
	3081063	201509	22	None	-	0	Guinea pig	7.1	pKd	=	7.1	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	398	9	4	3	3.4	N=C(NCCCc1c[nH]cn1)NCCC(c1ccc(F)c(F)c1)c1ccccn1	10.1021/jm00128a045
	CHEMBL60519	201509	22	None	-	0	Guinea pig	7.1	pKd	=	7.1	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	398	9	4	3	3.4	N=C(NCCCc1c[nH]cn1)NCCC(c1ccc(F)c(F)c1)c1ccccn1	10.1021/jm00128a045
	14660416	200729	1	None	-	0	Guinea pig	6.1	pKd	=	6.1	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	377	9	4	4	2.4	N/C(=N\CCC(c1cccc(N)c1)c1ccccn1)NCCCc1c[nH]cn1	10.1021/jm00128a045
	CHEMBL60006	200729	1	None	-	0	Guinea pig	6.1	pKd	=	6.1	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	377	9	4	4	2.4	N/C(=N\CCC(c1cccc(N)c1)c1ccccn1)NCCCc1c[nH]cn1	10.1021/jm00128a045
	42625384	169773	0	None	-	4	Guinea pig	5.1	pKd	=	5.1	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions	ChEMBL	209	4	3	2	-0.2	CC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/jm9000693
	CHEMBL443896	169773	0	None	-	4	Guinea pig	5.1	pKd	=	5.1	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced contractions	ChEMBL	209	4	3	2	-0.2	CC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/jm9000693
	14660359	199129	0	None	-	0	Guinea pig	7.1	pKd	=	7.1	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	396	9	4	3	3.7	N=C(NCCCc1c[nH]cn1)NCCC(c1cccc(Cl)c1)c1ccccn1	10.1021/jm00128a045
	CHEMBL58922	199129	0	None	-	0	Guinea pig	7.1	pKd	=	7.1	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	396	9	4	3	3.7	N=C(NCCCc1c[nH]cn1)NCCC(c1cccc(Cl)c1)c1ccccn1	10.1021/jm00128a045
	10447834	1933	4	None	-2	3	Rat	8.0	pKd	=	8.0	Functional	Compound was evaluated for mepyramine antagonism effects in rat aorta (relaxation) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in rat aorta (relaxation) at a mepyramine concentration of 100 nM	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	4026	1933	4	None	-2	3	Rat	8.0	pKd	=	8.0	Functional	Compound was evaluated for mepyramine antagonism effects in rat aorta (relaxation) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in rat aorta (relaxation) at a mepyramine concentration of 100 nM	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	CHEMBL275507	1933	4	None	-2	3	Rat	8.0	pKd	=	8.0	Functional	Compound was evaluated for mepyramine antagonism effects in rat aorta (relaxation) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in rat aorta (relaxation) at a mepyramine concentration of 100 nM	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	10447834	1933	4	None	-2	3	Rat	8.0	pKd	=	8.0	Functional	Maximum response (E max) against Histamine H1 receptor in rat aortaMaximum response (E max) against Histamine H1 receptor in rat aorta	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm0309147
	4026	1933	4	None	-2	3	Rat	8.0	pKd	=	8.0	Functional	Maximum response (E max) against Histamine H1 receptor in rat aortaMaximum response (E max) against Histamine H1 receptor in rat aorta	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm0309147
	CHEMBL275507	1933	4	None	-2	3	Rat	8.0	pKd	=	8.0	Functional	Maximum response (E max) against Histamine H1 receptor in rat aortaMaximum response (E max) against Histamine H1 receptor in rat aorta	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm0309147
	11741669	96753	0	None	-39	2	Rat	8.0	pKd	=	8.0	Functional	Apparent pA2 value of compound at 50 nM concentration of mepyramine in rat aortaApparent pA2 value of compound at 50 nM concentration of mepyramine in rat aorta	ChEMBL	399	11	3	3	4.3	c1ccc(C(CCc2nc(CCNCCc3cnc[nH]3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
	CHEMBL264491	96753	0	None	-39	2	Rat	8.0	pKd	=	8.0	Functional	Apparent pA2 value of compound at 50 nM concentration of mepyramine in rat aortaApparent pA2 value of compound at 50 nM concentration of mepyramine in rat aorta	ChEMBL	399	11	3	3	4.3	c1ccc(C(CCc2nc(CCNCCc3cnc[nH]3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
	10403687	2511	3	None	-1	2	Rat	8.0	pKd	=	8.0	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (relaxation) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig aorta (relaxation) at a mepyramine concentration of 100 nM	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	1205	2511	3	None	-1	2	Rat	8.0	pKd	=	8.0	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (relaxation) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig aorta (relaxation) at a mepyramine concentration of 100 nM	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	CHEMBL275035	2511	3	None	-1	2	Rat	8.0	pKd	=	8.0	Functional	Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (relaxation) at a mepyramine concentration of 100 nMCompound was evaluated for mepyramine antagonism effects in guinea pig aorta (relaxation) at a mepyramine concentration of 100 nM	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm991056a
	10403687	2511	3	None	-1	2	Rat	8.0	pKd	=	8.0	Functional	Maximum response (E max) against Histamine H1 receptor in guinea pig ileumMaximum response (E max) against Histamine H1 receptor in guinea pig ileum	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm0309147
	1205	2511	3	None	-1	2	Rat	8.0	pKd	=	8.0	Functional	Maximum response (E max) against Histamine H1 receptor in guinea pig ileumMaximum response (E max) against Histamine H1 receptor in guinea pig ileum	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm0309147
	CHEMBL275035	2511	3	None	-1	2	Rat	8.0	pKd	=	8.0	Functional	Maximum response (E max) against Histamine H1 receptor in guinea pig ileumMaximum response (E max) against Histamine H1 receptor in guinea pig ileum	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm0309147
	44274460	82411	0	None	-	0	Guinea pig	8.0	pKd	=	8.0	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	398	15	1	5	4.3	COc1ccc(CN(CCN(C)CCCCCCCCN)c2ccccn2)cc1	10.1016/s0960-894x(03)00113-6
	CHEMBL21735	82411	0	None	-	0	Guinea pig	8.0	pKd	=	8.0	Functional	Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandHistamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligand	ChEMBL	398	15	1	5	4.3	COc1ccc(CN(CCN(C)CCCCCCCCN)c2ccccn2)cc1	10.1016/s0960-894x(03)00113-6
	11726167	199657	0	None	-	0	Guinea pig	7.0	pKd	=	7.0	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	362	9	4	3	3.1	N=C(NCCCc1c[nH]cn1)NCCC(c1ccccc1)c1ccccn1	10.1021/jm00128a045
	CHEMBL59295	199657	0	None	-	0	Guinea pig	7.0	pKd	=	7.0	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	362	9	4	3	3.1	N=C(NCCCc1c[nH]cn1)NCCC(c1ccccc1)c1ccccn1	10.1021/jm00128a045
	14660386	202780	0	None	-	0	Guinea pig	7.0	pKd	=	7.0	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	395	9	4	2	4.3	N=C(NCCCc1c[nH]cn1)NCCC(c1ccccc1)c1ccc(Cl)cc1	10.1021/jm00128a045
	CHEMBL62142	202780	0	None	-	0	Guinea pig	7.0	pKd	=	7.0	Functional	Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.	ChEMBL	395	9	4	2	4.3	N=C(NCCCc1c[nH]cn1)NCCC(c1ccccc1)c1ccc(Cl)cc1	10.1021/jm00128a045
	1201	3964	1	None	-	0	Guinea pig	5.0	pKd	=	5.0	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	361	7	3	3	2.6	O=C(CC(c1ccccc1)c1ccccc1)NC(=NCCc1cnc[nH]1)N	10.1021/jm800841w
	25150700	3964	1	None	-	0	Guinea pig	5.0	pKd	=	5.0	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	361	7	3	3	2.6	O=C(CC(c1ccccc1)c1ccccc1)NC(=NCCc1cnc[nH]1)N	10.1021/jm800841w
	CHEMBL499301	3964	1	None	-	0	Guinea pig	5.0	pKd	=	5.0	Functional	Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityAntagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity	ChEMBL	361	7	3	3	2.6	O=C(CC(c1ccccc1)c1ccccc1)NC(=NCCc1cnc[nH]1)N	10.1021/jm800841w
	52937526	61302	0	None	-	0	Human	10.0	pKi	=	10	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	363	5	0	5	3.1	COc1ccc(Cc2nn(C[C@H]3CCCN3C)c(=O)c3ccccc23)cc1	10.1021/jm1013874
	CHEMBL1767137	61302	0	None	-	0	Human	10.0	pKi	=	10	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	363	5	0	5	3.1	COc1ccc(Cc2nn(C[C@H]3CCCN3C)c(=O)c3ccccc23)cc1	10.1021/jm1013874
	1530	2182	50	None	3	25	Human	9.8	pKi	=	9.8	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1021/jm100856p
	3827	2182	50	None	3	25	Human	9.8	pKi	=	9.8	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1021/jm100856p
	7206	2182	50	None	3	25	Human	9.8	pKi	=	9.8	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1021/jm100856p
	CHEMBL534	2182	50	None	3	25	Human	9.8	pKi	=	9.8	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1021/jm100856p
	DB00920	2182	50	None	3	25	Human	9.8	pKi	=	9.8	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1021/jm100856p
	15254720	61301	0	None	-	0	Human	9.8	pKi	=	9.8	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	367	4	0	4	3.7	CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/jm1013874
	CHEMBL1767136	61301	0	None	-	0	Human	9.8	pKi	=	9.8	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	367	4	0	4	3.7	CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/jm1013874
	52937527	61303	0	None	-	0	Human	9.8	pKi	=	9.8	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	349	4	1	5	2.8	CN1CCC[C@@H]1Cn1nc(Cc2ccc(O)cc2)c2ccccc2c1=O	10.1021/jm1013874
	CHEMBL1767138	61303	0	None	-	0	Human	9.8	pKi	=	9.8	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	349	4	1	5	2.8	CN1CCC[C@@H]1Cn1nc(Cc2ccc(O)cc2)c2ccccc2c1=O	10.1021/jm1013874
	15254720	61301	0	None	-	0	Human	9.8	pKi	=	9.8	Functional	Antagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	367	4	0	4	3.7	CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1016/j.bmc.2012.08.032
	CHEMBL1767136	61301	0	None	-	0	Human	9.8	pKi	=	9.8	Functional	Antagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	367	4	0	4	3.7	CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1016/j.bmc.2012.08.032
	52937631	61307	0	None	-	0	Human	9.7	pKi	=	9.7	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	347	4	0	4	3.4	Cc1ccc(Cc2nn(C[C@H]3CCCN3C)c(=O)c3ccccc23)cc1	10.1021/jm1013874
	CHEMBL1767141	61307	0	None	-	0	Human	9.7	pKi	=	9.7	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	347	4	0	4	3.4	Cc1ccc(Cc2nn(C[C@H]3CCCN3C)c(=O)c3ccccc23)cc1	10.1021/jm1013874
	71452871	80468	0	None	-	0	Human	9.6	pKi	=	9.6	Functional	Antagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	412	7	0	6	3.1	COCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cnccc2c1=O	10.1016/j.bmc.2012.08.032
	CHEMBL2146801	80468	0	None	-	0	Human	9.6	pKi	=	9.6	Functional	Antagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	412	7	0	6	3.1	COCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cnccc2c1=O	10.1016/j.bmc.2012.08.032
	203096	61299	3	None	-	0	Human	9.6	pKi	=	9.6	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	341	5	0	4	3.2	CN(C)CCn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/jm1013874
	CHEMBL1767134	61299	3	None	-	0	Human	9.6	pKi	=	9.6	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	341	5	0	4	3.2	CN(C)CCn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/jm1013874
	52937732	61314	0	None	-	0	Human	9.6	pKi	=	9.6	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	369	4	0	4	3.4	CN1CCC[C@@H]1Cn1nc(Cc2ccc(F)c(F)c2)c2ccccc2c1=O	10.1021/jm1013874
	CHEMBL1767149	61314	0	None	-	0	Human	9.6	pKi	=	9.6	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	369	4	0	4	3.4	CN1CCC[C@@H]1Cn1nc(Cc2ccc(F)c(F)c2)c2ccccc2c1=O	10.1021/jm1013874
	71458204	80476	0	None	-	0	Human	9.5	pKi	=	9.5	Functional	Antagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	368	4	0	5	3.1	CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ncccc2c1=O	10.1016/j.bmc.2012.08.032
	CHEMBL2146809	80476	0	None	-	0	Human	9.5	pKi	=	9.5	Functional	Antagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	368	4	0	5	3.1	CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ncccc2c1=O	10.1016/j.bmc.2012.08.032
	52937630	61306	0	None	-	0	Human	9.5	pKi	=	9.5	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	351	4	0	4	3.2	CN1CCC[C@@H]1Cn1nc(Cc2ccc(F)cc2)c2ccccc2c1=O	10.1021/jm1013874
	CHEMBL1767140	61306	0	None	-	0	Human	9.5	pKi	=	9.5	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	351	4	0	4	3.2	CN1CCC[C@@H]1Cn1nc(Cc2ccc(F)cc2)c2ccccc2c1=O	10.1021/jm1013874
	52937830	61319	0	None	-	0	Human	9.5	pKi	=	9.5	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	367	4	0	4	3.7	CN1CCC[C@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/jm1013874
	CHEMBL1767154	61319	0	None	-	0	Human	9.5	pKi	=	9.5	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	367	4	0	4	3.7	CN1CCC[C@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/jm1013874
	71458203	80472	0	None	-	0	Human	9.5	pKi	=	9.5	Functional	Antagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	368	4	0	5	3.1	CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cnccc2c1=O	10.1016/j.bmc.2012.08.032
	CHEMBL2146805	80472	0	None	-	0	Human	9.5	pKi	=	9.5	Functional	Antagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	368	4	0	5	3.1	CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cnccc2c1=O	10.1016/j.bmc.2012.08.032
	71452872	80434	0	None	-	0	Human	9.5	pKi	=	9.5	Functional	Antagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	368	4	0	5	3.1	CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cccnc2c1=O	10.1016/j.bmc.2012.08.032
	CHEMBL2146484	80434	0	None	-	0	Human	9.5	pKi	=	9.5	Functional	Antagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	368	4	0	5	3.1	CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cccnc2c1=O	10.1016/j.bmc.2012.08.032
	71461782	80473	0	None	-	0	Human	9.4	pKi	=	9.4	Functional	Antagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	410	7	0	5	4.3	CCCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cnccc2c1=O	10.1016/j.bmc.2012.08.032
	CHEMBL2146806	80473	0	None	-	0	Human	9.4	pKi	=	9.4	Functional	Antagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	410	7	0	5	4.3	CCCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cnccc2c1=O	10.1016/j.bmc.2012.08.032
	46861860	7491	1	None	-	0	Human	9.3	pKi	=	9.3	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	323	3	0	3	4.0	CN1CCCC(c2nc3ccccc3n2Cc2ccc(F)cc2)C1	10.1016/j.bmcl.2011.10.115
	CHEMBL1087089	7491	1	None	-	0	Human	9.3	pKi	=	9.3	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	323	3	0	3	4.0	CN1CCCC(c2nc3ccccc3n2Cc2ccc(F)cc2)C1	10.1016/j.bmcl.2011.10.115
	52937728	61310	0	None	-	0	Human	9.3	pKi	=	9.3	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	351	4	0	4	3.2	CN1CCC[C@@H]1Cn1nc(Cc2cccc(F)c2)c2ccccc2c1=O	10.1021/jm1013874
	CHEMBL1767145	61310	0	None	-	0	Human	9.3	pKi	=	9.3	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	351	4	0	4	3.2	CN1CCC[C@@H]1Cn1nc(Cc2cccc(F)c2)c2ccccc2c1=O	10.1021/jm1013874
	71456359	80470	0	None	-	0	Human	9.3	pKi	=	9.3	Functional	Antagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	411	7	0	5	3.8	COCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1016/j.bmc.2012.08.032
	CHEMBL2146803	80470	0	None	-	0	Human	9.3	pKi	=	9.3	Functional	Antagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	411	7	0	5	3.8	COCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1016/j.bmc.2012.08.032
	71458205	80478	0	None	-	0	Human	9.3	pKi	=	9.3	Functional	Antagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	412	7	0	6	3.1	COCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ncccc2c1=O	10.1016/j.bmc.2012.08.032
	CHEMBL2146811	80478	0	None	-	0	Human	9.3	pKi	=	9.3	Functional	Antagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	412	7	0	6	3.1	COCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ncccc2c1=O	10.1016/j.bmc.2012.08.032
	71451044	80474	0	None	-	0	Human	9.2	pKi	=	9.2	Functional	Antagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	410	7	0	5	4.3	CCCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cccnc2c1=O	10.1016/j.bmc.2012.08.032
	CHEMBL2146807	80474	0	None	-	0	Human	9.2	pKi	=	9.2	Functional	Antagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	410	7	0	5	4.3	CCCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cccnc2c1=O	10.1016/j.bmc.2012.08.032
	71454639	80477	0	None	-	0	Human	9.2	pKi	=	9.2	Functional	Antagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	410	7	0	5	4.3	CCCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ncccc2c1=O	10.1016/j.bmc.2012.08.032
	CHEMBL2146810	80477	0	None	-	0	Human	9.2	pKi	=	9.2	Functional	Antagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	410	7	0	5	4.3	CCCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ncccc2c1=O	10.1016/j.bmc.2012.08.032
	49864841	15731	0	None	-	0	Human	9.2	pKi	=	9.2	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assay	ChEMBL	266	1	1	4	1.6	C1=C(N2CCNCC2)c2nccn2Cc2ccccc21	10.1016/j.bmcl.2010.07.029
	CHEMBL1222552	15731	0	None	-	0	Human	9.2	pKi	=	9.2	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assay	ChEMBL	266	1	1	4	1.6	C1=C(N2CCNCC2)c2nccn2Cc2ccccc21	10.1016/j.bmcl.2010.07.029
	71449250	80471	0	None	-	0	Human	9.2	pKi	=	9.2	Functional	Antagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	368	4	0	5	3.1	CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccncc2c1=O	10.1016/j.bmc.2012.08.032
	CHEMBL2146804	80471	0	None	-	0	Human	9.2	pKi	=	9.2	Functional	Antagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	368	4	0	5	3.1	CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccncc2c1=O	10.1016/j.bmc.2012.08.032
	52937731	61313	0	None	-	0	Human	9.1	pKi	=	9.1	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	347	4	0	4	3.4	Cc1cccc(Cc2nn(C[C@H]3CCCN3C)c(=O)c3ccccc23)c1	10.1021/jm1013874
	CHEMBL1767148	61313	0	None	-	0	Human	9.1	pKi	=	9.1	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	347	4	0	4	3.4	Cc1cccc(Cc2nn(C[C@H]3CCCN3C)c(=O)c3ccccc23)c1	10.1021/jm1013874
	46861858	8562	0	None	-	0	Human	9.1	pKi	=	9.1	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	335	5	0	4	3.9	CN1CCCC(c2nc3ccccc3n2CCOc2ccccc2)C1	10.1016/j.bmcl.2011.10.115
	CHEMBL1094510	8562	0	None	-	0	Human	9.1	pKi	=	9.1	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	335	5	0	4	3.9	CN1CCCC(c2nc3ccccc3n2CCOc2ccccc2)C1	10.1016/j.bmcl.2011.10.115
	57402315	69712	0	None	-	0	Human	9.1	pKi	=	9.1	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	311	3	1	4	2.9	Fc1ccc(Cn2c([C@H]3CNCCO3)nc3ccccc32)cc1	10.1016/j.bmcl.2011.10.115
	CHEMBL1935442	69712	0	None	-	0	Human	9.1	pKi	=	9.1	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	311	3	1	4	2.9	Fc1ccc(Cn2c([C@H]3CNCCO3)nc3ccccc32)cc1	10.1016/j.bmcl.2011.10.115
	46888857	8712	0	None	-	0	Human	9.1	pKi	=	9.1	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	323	3	0	3	4.0	CN1CCC[C@@H](c2nc3ccccc3n2Cc2ccc(F)cc2)C1	10.1016/j.bmcl.2011.10.115
	CHEMBL1095819	8712	0	None	-	0	Human	9.1	pKi	=	9.1	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	323	3	0	3	4.0	CN1CCC[C@@H](c2nc3ccccc3n2Cc2ccc(F)cc2)C1	10.1016/j.bmcl.2011.10.115
	71461781	80469	0	None	-	0	Human	9.0	pKi	=	9.0	Functional	Antagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	409	7	0	4	4.9	CCCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1016/j.bmc.2012.08.032
	CHEMBL2146802	80469	0	None	-	0	Human	9.0	pKi	=	9.0	Functional	Antagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	409	7	0	4	4.9	CCCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1016/j.bmc.2012.08.032
	57398830	69706	0	None	-	0	Human	9.0	pKi	=	9	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	353	5	1	4	3.4	OCCN1CCCC(c2nc3ccccc3n2Cc2ccc(F)cc2)C1	10.1016/j.bmcl.2011.10.115
	CHEMBL1935436	69706	0	None	-	0	Human	9.0	pKi	=	9	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	353	5	1	4	3.4	OCCN1CCCC(c2nc3ccccc3n2Cc2ccc(F)cc2)C1	10.1016/j.bmcl.2011.10.115
	57400501	69708	0	None	-	0	Human	9.0	pKi	=	9	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	321	5	1	4	3.6	c1ccc(OCCn2c(C3CCCNC3)nc3ccccc32)cc1	10.1016/j.bmcl.2011.10.115
	CHEMBL1935438	69708	0	None	-	0	Human	9.0	pKi	=	9	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	321	5	1	4	3.6	c1ccc(OCCn2c(C3CCCNC3)nc3ccccc32)cc1	10.1016/j.bmcl.2011.10.115
	57395287	69711	0	None	-	0	Human	9.0	pKi	=	9	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	307	3	1	4	3.1	Cc1ccc(Cn2c([C@H]3CNCCO3)nc3ccccc32)cc1	10.1016/j.bmcl.2011.10.115
	CHEMBL1935441	69711	0	None	-	0	Human	9.0	pKi	=	9	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	307	3	1	4	3.1	Cc1ccc(Cn2c([C@H]3CNCCO3)nc3ccccc32)cc1	10.1016/j.bmcl.2011.10.115
	71456360	80475	0	None	-	0	Human	9.0	pKi	=	9	Functional	Antagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	412	7	0	6	3.1	COCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cccnc2c1=O	10.1016/j.bmc.2012.08.032
	CHEMBL2146808	80475	0	None	-	0	Human	9.0	pKi	=	9	Functional	Antagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	412	7	0	6	3.1	COCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cccnc2c1=O	10.1016/j.bmc.2012.08.032
	52937222	61321	0	None	-	0	Human	9.0	pKi	=	9	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	367	3	0	4	3.9	CN1CCC(n2nc(Cc3ccc(Cl)cc3)c3ccccc3c2=O)CC1	10.1021/jm1013874
	CHEMBL1767156	61321	0	None	-	0	Human	9.0	pKi	=	9	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	367	3	0	4	3.9	CN1CCC(n2nc(Cc3ccc(Cl)cc3)c3ccccc3c2=O)CC1	10.1021/jm1013874
	57404030	69707	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	309	3	1	3	3.7	Fc1ccc(Cn2c([C@@H]3CCCNC3)nc3ccccc32)cc1	10.1016/j.bmcl.2011.10.115
	CHEMBL1935437	69707	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	309	3	1	3	3.7	Fc1ccc(Cn2c([C@@H]3CCCNC3)nc3ccccc32)cc1	10.1016/j.bmcl.2011.10.115
	2267	559	71	None	32	14	Human	8.9	pKi	=	8.9	Functional	Antagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmc.2012.08.032
	271	559	71	None	32	14	Human	8.9	pKi	=	8.9	Functional	Antagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmc.2012.08.032
	7121	559	71	None	32	14	Human	8.9	pKi	=	8.9	Functional	Antagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmc.2012.08.032
	CHEMBL639	559	71	None	32	14	Human	8.9	pKi	=	8.9	Functional	Antagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmc.2012.08.032
	DB00972	559	71	None	32	14	Human	8.9	pKi	=	8.9	Functional	Antagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmc.2012.08.032
	2267	559	71	None	32	14	Human	8.9	pKi	=	8.9	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmcl.2016.11.022
	271	559	71	None	32	14	Human	8.9	pKi	=	8.9	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmcl.2016.11.022
	7121	559	71	None	32	14	Human	8.9	pKi	=	8.9	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmcl.2016.11.022
	CHEMBL639	559	71	None	32	14	Human	8.9	pKi	=	8.9	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmcl.2016.11.022
	DB00972	559	71	None	32	14	Human	8.9	pKi	=	8.9	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmcl.2016.11.022
	2267	559	71	None	32	14	Human	8.9	pKi	=	8.9	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1021/jm1013874
	271	559	71	None	32	14	Human	8.9	pKi	=	8.9	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1021/jm1013874
	7121	559	71	None	32	14	Human	8.9	pKi	=	8.9	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1021/jm1013874
	CHEMBL639	559	71	None	32	14	Human	8.9	pKi	=	8.9	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1021/jm1013874
	DB00972	559	71	None	32	14	Human	8.9	pKi	=	8.9	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1021/jm1013874
	71456361	80479	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	369	4	0	6	2.5	CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2nccnc2c1=O	10.1016/j.bmc.2012.08.032
	CHEMBL2146812	80479	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	369	4	0	6	2.5	CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2nccnc2c1=O	10.1016/j.bmc.2012.08.032
	57400503	69714	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	323	3	1	4	3.8	Cc1ccc(Cn2c(C3CNCCS3)nc3ccccc32)cc1	10.1016/j.bmcl.2011.10.115
	CHEMBL1935444	69714	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	323	3	1	4	3.8	Cc1ccc(Cn2c(C3CNCCS3)nc3ccccc32)cc1	10.1016/j.bmcl.2011.10.115
	57397056	69716	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	327	3	1	4	3.6	Fc1ccc(Cn2c([C@H]3CNCCS3)nc3ccccc32)cc1	10.1016/j.bmcl.2011.10.115
	CHEMBL1935446	69716	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	327	3	1	4	3.6	Fc1ccc(Cn2c([C@H]3CNCCS3)nc3ccccc32)cc1	10.1016/j.bmcl.2011.10.115
	57400505	69717	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	339	4	1	5	3.5	COc1ccc(Cn2c([C@H]3CNCCS3)nc3ccccc32)cc1	10.1016/j.bmcl.2011.10.115
	CHEMBL1935447	69717	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	339	4	1	5	3.5	COc1ccc(Cn2c([C@H]3CNCCS3)nc3ccccc32)cc1	10.1016/j.bmcl.2011.10.115
	57400503	69714	0	None	-	0	Human	8.8	pKi	=	8.8	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	323	3	1	4	3.8	Cc1ccc(Cn2c(C3CNCCS3)nc3ccccc32)cc1	10.1016/j.bmcl.2011.10.115
	CHEMBL1935444	69714	0	None	-	0	Human	8.8	pKi	=	8.8	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	323	3	1	4	3.8	Cc1ccc(Cn2c(C3CNCCS3)nc3ccccc32)cc1	10.1016/j.bmcl.2011.10.115
	52937729	61311	0	None	-	0	Human	8.8	pKi	=	8.8	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	367	4	0	4	3.7	CN1CCC[C@@H]1Cn1nc(Cc2cccc(Cl)c2)c2ccccc2c1=O	10.1021/jm1013874
	CHEMBL1767146	61311	0	None	-	0	Human	8.8	pKi	=	8.8	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	367	4	0	4	3.7	CN1CCC[C@@H]1Cn1nc(Cc2cccc(Cl)c2)c2ccccc2c1=O	10.1021/jm1013874
	52937829	61318	0	None	-	0	Human	8.8	pKi	=	8.8	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	313	6	0	4	3.2	CCCCCc1nn(C[C@H]2CCCN2C)c(=O)c2ccccc12	10.1021/jm1013874
	CHEMBL1767153	61318	0	None	-	0	Human	8.8	pKi	=	8.8	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	313	6	0	4	3.2	CCCCCc1nn(C[C@H]2CCCN2C)c(=O)c2ccccc12	10.1021/jm1013874
	57400502	69713	0	None	-	0	Human	8.7	pKi	=	8.7	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	321	3	1	4	3.4	Cc1ccc(Cn2c(C3CNCCO3)nc3ccccc32)cc1C	10.1016/j.bmcl.2011.10.115
	CHEMBL1935443	69713	0	None	-	0	Human	8.7	pKi	=	8.7	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	321	3	1	4	3.4	Cc1ccc(Cn2c(C3CNCCO3)nc3ccccc32)cc1C	10.1016/j.bmcl.2011.10.115
	52937730	61312	0	None	-	0	Human	8.7	pKi	=	8.7	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	363	5	0	5	3.1	COc1cccc(Cc2nn(C[C@H]3CCCN3C)c(=O)c3ccccc23)c1	10.1021/jm1013874
	CHEMBL1767147	61312	0	None	-	0	Human	8.7	pKi	=	8.7	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	363	5	0	5	3.1	COc1cccc(Cc2nn(C[C@H]3CCCN3C)c(=O)c3ccccc23)c1	10.1021/jm1013874
	52945978	18796	0	None	-	0	Human	8.0	pKi	=	8	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	335	4	2	2	3.7	O=C(O)CCNC1CC[C@]2(Cc3ccccc3Cc3ccccc32)C1	10.1021/jm100856p
	CHEMBL1278114	18796	0	None	-	0	Human	8.0	pKi	=	8	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	335	4	2	2	3.7	O=C(O)CCNC1CC[C@]2(Cc3ccccc3Cc3ccccc32)C1	10.1021/jm100856p
	17747460	61329	12	None	-	2	Human	8.0	pKi	=	8	Functional	Antagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	640	14	0	6	7.8	O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1	10.1016/j.bmc.2012.08.032
	CHEMBL1767164	61329	12	None	-	2	Human	8.0	pKi	=	8	Functional	Antagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	640	14	0	6	7.8	O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1	10.1016/j.bmc.2012.08.032
	17747460	61329	12	None	-	2	Human	8.0	pKi	=	8	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	640	14	0	6	7.8	O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1	10.1016/j.bmcl.2016.11.022
	CHEMBL1767164	61329	12	None	-	2	Human	8.0	pKi	=	8	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	640	14	0	6	7.8	O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1	10.1016/j.bmcl.2016.11.022
	52937018	61300	0	None	-	0	Human	8.0	pKi	=	8	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	355	6	0	4	3.6	CN(C)CCCn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/jm1013874
	CHEMBL1767135	61300	0	None	-	0	Human	8.0	pKi	=	8	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	355	6	0	4	3.6	CN(C)CCCn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/jm1013874
	17747460	61329	12	None	-	2	Human	8.0	pKi	=	8	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	640	14	0	6	7.8	O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1	10.1021/jm1013874
	CHEMBL1767164	61329	12	None	-	2	Human	8.0	pKi	=	8	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	640	14	0	6	7.8	O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1	10.1021/jm1013874
	49836636	18677	0	None	-	0	Human	7.0	pKi	=	7	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	375	2	1	3	4.5	O=C(O)C1=CCCN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1277125	18677	0	None	-	0	Human	7.0	pKi	=	7	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	375	2	1	3	4.5	O=C(O)C1=CCCN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)C1	10.1021/jm100856p
	49836522	18795	0	None	-	0	Human	7.0	pKi	=	7	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	376	2	2	3	3.0	O=C(O)C1CN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)CCN1	10.1021/jm100856p
	CHEMBL1278113	18795	0	None	-	0	Human	7.0	pKi	=	7	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	376	2	2	3	3.0	O=C(O)C1CN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)CCN1	10.1021/jm100856p
	11648990	95646	0	None	-	0	Human	7.0	pKi	=	7	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	498	6	0	8	5.4	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6onc(C)c6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL257946	95646	0	None	-	0	Human	7.0	pKi	=	7	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	498	6	0	8	5.4	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6onc(C)c6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	185	4006	60	None	-	1	Human	6.0	pKi	=	6	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	10.1021/jm100856p
	5311271	4006	60	None	-	1	Human	6.0	pKi	=	6	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	10.1021/jm100856p
	CHEMBL74355	4006	60	None	-	1	Human	6.0	pKi	=	6	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	10.1021/jm100856p
	DB16351	4006	60	None	-	1	Human	6.0	pKi	=	6	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	10.1021/jm100856p
	49836740	18704	0	None	-	0	Human	6.0	pKi	=	6	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	425	2	1	4	4.9	O=C(O)C1CCN(C2CCC3(C2)C(=O)c2cc(Cl)ccc2Oc2ccccc23)CC1	10.1021/jm100856p
	CHEMBL1277401	18704	0	None	-	0	Human	6.0	pKi	=	6	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	425	2	1	4	4.9	O=C(O)C1CCN(C2CCC3(C2)C(=O)c2cc(Cl)ccc2Oc2ccccc23)CC1	10.1021/jm100856p
	44454458	95125	0	None	-	0	Human	6.0	pKi	=	6	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	618	6	0	8	7.1	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C(C)(C)C)oc6c(Br)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL255566	95125	0	None	-	0	Human	6.0	pKi	=	6	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	618	6	0	8	7.1	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C(C)(C)C)oc6c(Br)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	44454382	95582	0	None	-	0	Human	6.0	pKi	=	6	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	517	6	0	8	5.2	Cc1ccc2c(-c3nnc(SCCCN4CCc5nc6ccc(Cl)cn6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	CHEMBL257716	95582	0	None	-	0	Human	6.0	pKi	=	6	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	517	6	0	8	5.2	Cc1ccc2c(-c3nnc(SCCCN4CCc5nc6ccc(Cl)cn6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	11642163	97505	0	None	-	0	Human	6.0	pKi	=	6	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	522	6	0	9	5.3	Cc1nc(C)c(-c2nnc(SCCCN3CCc4ccc5oc(C(F)(F)F)nc5c4CC3)n2C)s1	10.1016/j.bmcl.2007.12.042
	CHEMBL270376	97505	0	None	-	0	Human	6.0	pKi	=	6	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	522	6	0	9	5.3	Cc1nc(C)c(-c2nnc(SCCCN3CCc4ccc5oc(C(F)(F)F)nc5c4CC3)n2C)s1	10.1016/j.bmcl.2007.12.042
	11663526	97752	0	None	-	0	Human	6.0	pKi	=	6	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	514	6	0	8	5.8	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C)sc6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL271632	97752	0	None	-	0	Human	6.0	pKi	=	6	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	514	6	0	8	5.8	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C)sc6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	44454223	97974	0	None	-	0	Human	6.0	pKi	=	6	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	542	6	0	8	4.7	CC(=O)N1CCOc2cc3c(cc21)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.066
	CHEMBL272702	97974	0	None	-	0	Human	6.0	pKi	=	6	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	542	6	0	8	4.7	CC(=O)N1CCOc2cc3c(cc21)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.066
	11527195	98058	0	None	-	0	Human	6.0	pKi	=	6	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	590	6	0	8	6.5	Cc1ccc2c(-c3nnc(SCCC(C)N4CCc5cc6nc(C)oc6c(Br)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL273165	98058	0	None	-	0	Human	6.0	pKi	=	6	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	590	6	0	8	6.5	Cc1ccc2c(-c3nnc(SCCC(C)N4CCc5cc6nc(C)oc6c(Br)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	11721190	155274	0	None	-	0	Human	6.0	pKi	=	6	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	578	7	0	10	5.8	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6oc(-c7cc(C)nn7C)nc6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	CHEMBL402853	155274	0	None	-	0	Human	6.0	pKi	=	6	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	578	7	0	10	5.8	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6oc(-c7cc(C)nn7C)nc6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	134143913	150330	0	None	-	0	Human	6.0	pKi	=	6	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	497	9	0	6	5.1	N#Cc1ccc(N2CCN(CCc3ccc(OCCCN4CCCCCC4)cc3)CC2)c2ncccc12	10.1016/j.bmcl.2016.11.022
	CHEMBL3953018	150330	0	None	-	0	Human	6.0	pKi	=	6	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	497	9	0	6	5.1	N#Cc1ccc(N2CCN(CCc3ccc(OCCCN4CCCCCC4)cc3)CC2)c2ncccc12	10.1016/j.bmcl.2016.11.022
	57393573	69709	0	None	-	0	Human	7.9	pKi	=	7.9	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	406	7	0	5	3.4	CN(C)C(=O)CN1CCCC(c2nc3ccccc3n2CCOc2ccccc2)C1	10.1016/j.bmcl.2011.10.115
	CHEMBL1935439	69709	0	None	-	0	Human	7.9	pKi	=	7.9	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	406	7	0	5	3.4	CN(C)C(=O)CN1CCCC(c2nc3ccccc3n2CCOc2ccccc2)C1	10.1016/j.bmcl.2011.10.115
	49836525	18807	0	None	-	0	Human	7.9	pKi	=	7.9	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	375	2	1	2	4.4	CC1(C(=O)O)CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1278202	18807	0	None	-	0	Human	7.9	pKi	=	7.9	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	375	2	1	2	4.4	CC1(C(=O)O)CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	57780020	143450	0	None	-	0	Human	7.9	pKi	=	7.9	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	600	15	1	6	6.6	CCCCc1cc(N2CCN(CCc3ccc(OCCCN4CCCCCC4)cc3)CC2)c2nc(CCC(=O)O)ccc2c1	10.1016/j.bmcl.2016.11.022
	CHEMBL3898341	143450	0	None	-	0	Human	7.9	pKi	=	7.9	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	600	15	1	6	6.6	CCCCc1cc(N2CCN(CCc3ccc(OCCCN4CCCCCC4)cc3)CC2)c2nc(CCC(=O)O)ccc2c1	10.1016/j.bmcl.2016.11.022
	57780017	148118	0	None	-	0	Human	7.9	pKi	=	7.9	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	544	12	1	6	5.3	O=C(O)CCc1ccc2cccc(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)c2n1	10.1016/j.bmcl.2016.11.022
	CHEMBL3935303	148118	0	None	-	0	Human	7.9	pKi	=	7.9	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	544	12	1	6	5.3	O=C(O)CCc1ccc2cccc(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)c2n1	10.1016/j.bmcl.2016.11.022
	49834051	15747	0	None	-	0	Human	7.9	pKi	=	7.9	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assay	ChEMBL	364	3	1	5	2.2	O=C(O)C1CC(N2CCN(C3=Cc4ccccc4Cn4ccnc43)CC2)C1	10.1016/j.bmcl.2010.07.029
	CHEMBL1222626	15747	0	None	-	0	Human	7.9	pKi	=	7.9	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assay	ChEMBL	364	3	1	5	2.2	O=C(O)C1CC(N2CCN(C3=Cc4ccccc4Cn4ccnc43)CC2)C1	10.1016/j.bmcl.2010.07.029
	24803639	61331	0	None	-	0	Human	7.9	pKi	=	7.9	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	622	14	1	7	6.8	O=c1c2ccccc2c(Cc2ccc(O)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1	10.1021/jm1013874
	CHEMBL1767166	61331	0	None	-	0	Human	7.9	pKi	=	7.9	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	622	14	1	7	6.8	O=c1c2ccccc2c(Cc2ccc(O)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1	10.1021/jm1013874
	24803483	61332	0	None	-	0	Human	7.9	pKi	=	7.9	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	654	15	0	6	8.2	O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCCc1ccc(OCCCN2CCCCCC2)cc1	10.1021/jm1013874
	CHEMBL1767167	61332	0	None	-	0	Human	7.9	pKi	=	7.9	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	654	15	0	6	8.2	O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCCc1ccc(OCCCN2CCCCCC2)cc1	10.1021/jm1013874
	49836738	18694	0	None	-	0	Human	6.9	pKi	=	6.9	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	377	2	1	3	4.6	O=C(O)[C@@H]1CCCN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1277311	18694	0	None	-	0	Human	6.9	pKi	=	6.9	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	377	2	1	3	4.6	O=C(O)[C@@H]1CCCN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)C1	10.1021/jm100856p
	11591601	155333	0	None	-	0	Human	6.9	pKi	=	6.9	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	512	7	0	8	5.6	CCc1noc2cc3c(cc12)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.066
	CHEMBL403181	155333	0	None	-	0	Human	6.9	pKi	=	6.9	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	512	7	0	8	5.6	CCc1noc2cc3c(cc12)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.066
	49833882	15760	0	None	-	0	Human	6.9	pKi	=	6.9	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assay	ChEMBL	392	3	1	5	3.0	O=C(O)C1CCC(N2CCN(C3=Cc4ccccc4Cn4ccnc43)CC2)CC1	10.1016/j.bmcl.2010.07.029
	CHEMBL1222692	15760	0	None	-	0	Human	6.9	pKi	=	6.9	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assay	ChEMBL	392	3	1	5	3.0	O=C(O)C1CCC(N2CCN(C3=Cc4ccccc4Cn4ccnc43)CC2)CC1	10.1016/j.bmcl.2010.07.029
	49833886	15778	0	None	-	0	Human	6.9	pKi	=	6.9	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assay	ChEMBL	396	5	1	6	2.5	COc1cnc2n1Cc1ccccc1C=C2N1CCN(CC(C)(C)C(=O)O)CC1	10.1016/j.bmcl.2010.07.029
	CHEMBL1222764	15778	0	None	-	0	Human	6.9	pKi	=	6.9	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assay	ChEMBL	396	5	1	6	2.5	COc1cnc2n1Cc1ccccc1C=C2N1CCN(CC(C)(C)C(=O)O)CC1	10.1016/j.bmcl.2010.07.029
	11657494	95509	0	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	644	7	0	8	7.2	Cc1ccc2c(-c3nnc(SCCCCN4CCc5cc6nc(C(F)(F)F)oc6c(Br)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL257369	95509	0	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	644	7	0	8	7.2	Cc1ccc2c(-c3nnc(SCCCCN4CCc5cc6nc(C(F)(F)F)oc6c(Br)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	11641641	97507	0	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	487	6	0	7	5.2	Cn1c(SCCCN2CCc3ccc4oc(C(F)(F)F)nc4c3CC2)nnc1-c1ccccc1	10.1016/j.bmcl.2007.12.042
	CHEMBL270387	97507	0	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	487	6	0	7	5.2	Cn1c(SCCCN2CCc3ccc4oc(C(F)(F)F)nc4c3CC2)nnc1-c1ccccc1	10.1016/j.bmcl.2007.12.042
	24749507	14008	4	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilizationAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization	ChEMBL	421	7	0	4	3.4	O=C(c1ccccc1)N1CCN(c2ccc(OCCCN3CCCCC3)cc2)C(=O)C1	10.1021/jm0708228
	CHEMBL1197067	14008	4	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilizationAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization	ChEMBL	421	7	0	4	3.4	O=C(c1ccccc1)N1CCN(c2ccc(OCCCN3CCCCC3)cc2)C(=O)C1	10.1021/jm0708228
	CHEMBL559206	14008	4	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilizationAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization	ChEMBL	421	7	0	4	3.4	O=C(c1ccccc1)N1CCN(c2ccc(OCCCN3CCCCC3)cc2)C(=O)C1	10.1021/jm0708228
	57397055	69705	0	None	-	0	Human	7.9	pKi	=	7.9	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	390	5	0	5	4.6	Fc1ccc(Cn2c(C3CCCN(Cc4ncco4)C3)nc3ccccc32)cc1	10.1016/j.bmcl.2011.10.115
	CHEMBL1935435	69705	0	None	-	0	Human	7.9	pKi	=	7.9	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	390	5	0	5	4.6	Fc1ccc(Cn2c(C3CCCN(Cc4ncco4)C3)nc3ccccc32)cc1	10.1016/j.bmcl.2011.10.115
	49836294	18779	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	387	2	0	3	4.4	COC(=O)C1=CCCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1278020	18779	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	387	2	0	3	4.4	COC(=O)C1=CCCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	49836524	18806	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	361	2	1	2	4.0	O=C(O)C1CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1278201	18806	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	361	2	1	2	4.0	O=C(O)C1CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	134136763	142848	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	500	11	0	5	6.0	c1cnc2c(N3CCN(CCCCc4ccc(OCCCN5CCCCCC5)cc4)CC3)cccc2c1	10.1016/j.bmcl.2016.11.022
	CHEMBL3893197	142848	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	500	11	0	5	6.0	c1cnc2c(N3CCN(CCCCc4ccc(OCCCN5CCCCCC5)cc4)CC3)cccc2c1	10.1016/j.bmcl.2016.11.022
	57780007	146991	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	572	13	1	6	5.8	CCc1cc(N2CCN(CCc3ccc(OCCCN4CCCCCC4)cc3)CC2)c2nc(CCC(=O)O)ccc2c1	10.1016/j.bmcl.2016.11.022
	CHEMBL3926412	146991	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	572	13	1	6	5.8	CCc1cc(N2CCN(CCc3ccc(OCCCN4CCCCCC4)cc3)CC2)c2nc(CCC(=O)O)ccc2c1	10.1016/j.bmcl.2016.11.022
	24803797	61080	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	626	11	0	6	7.6	O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C1CCCN(CCc2ccc(OCCCN3CCCCCC3)cc2)CC1	10.1021/jm1013874
	CHEMBL1765111	61080	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	626	11	0	6	7.6	O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C1CCCN(CCc2ccc(OCCCN3CCCCCC3)cc2)CC1	10.1021/jm1013874
	24803798	61325	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	640	12	0	6	7.9	O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C1CCCN(CCCc2ccc(OCCCN3CCCCCC3)cc2)CC1	10.1021/jm1013874
	CHEMBL1767160	61325	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	640	12	0	6	7.9	O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C1CCCN(CCCc2ccc(OCCCN3CCCCCC3)cc2)CC1	10.1021/jm1013874
	49836737	18685	0	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	395	2	1	3	4.7	O=C(O)C1(F)CCN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)CC1	10.1021/jm100856p
	CHEMBL1277217	18685	0	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	395	2	1	3	4.7	O=C(O)C1(F)CCN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)CC1	10.1021/jm100856p
	49836189	18780	0	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	373	2	1	2	4.3	O=C(O)C1=CCCN(C2CC[C@@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1278021	18780	0	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	373	2	1	2	4.3	O=C(O)C1=CCCN(C2CC[C@@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	44454309	97639	0	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	514	6	1	8	4.3	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6c(cc5CC4)OCC(=O)N6)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL271066	97639	0	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	514	6	1	8	4.3	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6c(cc5CC4)OCC(=O)N6)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	11568714	95307	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	454	6	0	9	4.3	Cc1nc2cc3c(cc2s1)CCN(CCCSc1nnc(-c2ocnc2C)n1C)CC3	10.1016/j.bmcl.2007.12.066
	CHEMBL256471	95307	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	454	6	0	9	4.3	Cc1nc2cc3c(cc2s1)CCN(CCCSc1nnc(-c2ocnc2C)n1C)CC3	10.1016/j.bmcl.2007.12.066
	11606378	95315	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	548	7	0	8	6.2	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6nc(C(C)(F)F)oc6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	CHEMBL256488	95315	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	548	7	0	8	6.2	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6nc(C(C)(F)F)oc6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	11533473	97551	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	503	6	0	9	4.3	Cc1cnc(-c2nnc(SCCCN3CCc4ccc5oc(C(F)(F)F)nc5c4CC3)n2C)cn1	10.1016/j.bmcl.2007.12.042
	CHEMBL270602	97551	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	503	6	0	9	4.3	Cc1cnc(-c2nnc(SCCCN3CCc4ccc5oc(C(F)(F)F)nc5c4CC3)n2C)cn1	10.1016/j.bmcl.2007.12.042
	44454401	155140	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	554	6	0	8	6.7	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C(C)(C)C)oc6c(C)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL402087	155140	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	554	6	0	8	6.7	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C(C)(C)C)oc6c(C)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	11504077	168829	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	488	7	0	9	4.6	Cc1ncoc1-c1nnc(SCCCN2CCc3ccc4oc(C(C)(F)F)nc4c3CC2)n1C	10.1016/j.bmcl.2007.12.042
	CHEMBL437792	168829	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	488	7	0	9	4.6	Cc1ncoc1-c1nnc(SCCCN2CCc3ccc4oc(C(C)(F)F)nc4c3CC2)n1C	10.1016/j.bmcl.2007.12.042
	52937733	61315	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	393	6	0	6	3.1	COc1ccc(Cc2nn(C[C@H]3CCCN3C)c(=O)c3ccccc23)cc1OC	10.1021/jm1013874
	CHEMBL1767150	61315	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	393	6	0	6	3.1	COc1ccc(Cc2nn(C[C@H]3CCCN3C)c(=O)c3ccccc23)cc1OC	10.1021/jm1013874
	57391843	69704	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	436	5	0	5	3.3	O=C(CN1CCCC(c2nc3ccccc3n2Cc2ccc(F)cc2)C1)N1CCOCC1	10.1016/j.bmcl.2011.10.115
	CHEMBL1935434	69704	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	436	5	0	5	3.3	O=C(CN1CCCC(c2nc3ccccc3n2Cc2ccc(F)cc2)C1)N1CCOCC1	10.1016/j.bmcl.2011.10.115
	24804150	80480	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	641	14	0	7	7.2	O=c1c2ccncc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1	10.1016/j.bmc.2012.08.032
	CHEMBL2146813	80480	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human H1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	641	14	0	7	7.2	O=c1c2ccncc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1	10.1016/j.bmc.2012.08.032
	49836412	18724	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	375	2	1	2	4.4	O=C(O)[C@@H]1CCCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1277584	18724	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	375	2	1	2	4.4	O=C(O)[C@@H]1CCCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	49836295	18766	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	373	2	1	2	4.3	O=C(O)C1=CCCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1277935	18766	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	373	2	1	2	4.3	O=C(O)C1=CCCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	57780008	149726	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	472	9	0	5	5.2	c1cnc2c(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)cccc2c1	10.1016/j.bmcl.2016.11.022
	CHEMBL3947980	149726	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	472	9	0	5	5.2	c1cnc2c(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)cccc2c1	10.1016/j.bmcl.2016.11.022
	49864886	15745	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assay	ChEMBL	366	4	1	5	2.6	CC1CN(C2=Cc3ccccc3Cn3ccnc32)CC(C)N1CCC(=O)O	10.1016/j.bmcl.2010.07.029
	CHEMBL1222624	15745	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assay	ChEMBL	366	4	1	5	2.6	CC1CN(C2=Cc3ccccc3Cn3ccnc32)CC(C)N1CCC(=O)O	10.1016/j.bmcl.2010.07.029
	24803799	61326	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	654	13	0	6	8.3	O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C1CCCN(CCCCc2ccc(OCCCN3CCCCCC3)cc2)CC1	10.1021/jm1013874
	CHEMBL1767161	61326	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	654	13	0	6	8.3	O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C1CCCN(CCCCc2ccc(OCCCN3CCCCCC3)cc2)CC1	10.1021/jm1013874
	49836635	18667	0	None	-	0	Human	6.7	pKi	=	6.7	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	359	2	1	2	4.0	O=C(O)C=C1CN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1277035	18667	0	None	-	0	Human	6.7	pKi	=	6.7	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	359	2	1	2	4.0	O=C(O)C=C1CN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	49836741	18713	0	None	-	0	Human	6.7	pKi	=	6.7	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	425	2	1	4	4.8	O=C(O)C1CCN(C2CCC3(C2)C(=O)c2cc(F)ccc2Sc2ccccc23)CC1	10.1021/jm100856p
	CHEMBL1277491	18713	0	None	-	0	Human	6.7	pKi	=	6.7	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	425	2	1	4	4.8	O=C(O)C1CCN(C2CCC3(C2)C(=O)c2cc(F)ccc2Sc2ccccc23)CC1	10.1021/jm100856p
	49836842	18714	0	None	-	0	Human	6.7	pKi	=	6.7	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	425	2	1	4	4.9	O=C(O)[C@@H]1CCCN(C2CCC3(C2)C(=O)c2cc(Cl)ccc2Oc2ccccc23)C1	10.1021/jm100856p
	CHEMBL1277492	18714	0	None	-	0	Human	6.7	pKi	=	6.7	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	425	2	1	4	4.9	O=C(O)[C@@H]1CCCN(C2CCC3(C2)C(=O)c2cc(Cl)ccc2Oc2ccccc23)C1	10.1021/jm100856p
	57780016	150297	0	None	-	0	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	542	11	1	6	5.3	O=C(O)/C=C/c1ccc2cccc(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)c2n1	10.1016/j.bmcl.2016.11.022
	CHEMBL3952802	150297	0	None	-	0	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	542	11	1	6	5.3	O=C(O)/C=C/c1ccc2cccc(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)c2n1	10.1016/j.bmcl.2016.11.022
	11585248	95314	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	604	8	0	8	6.8	CCc1nc2cc3c(c(Br)c2o1)CCN(CCCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.066
	CHEMBL256482	95314	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	604	8	0	8	6.8	CCc1nc2cc3c(c(Br)c2o1)CCN(CCCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.066
	11669953	95540	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	468	6	0	9	2.7	Cc1ncoc1-c1nnc(SCCCN2CCc3cc4c(cc3CC2)N(C)C(=O)CO4)n1C	10.1016/j.bmcl.2007.12.066
	CHEMBL257534	95540	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	468	6	0	9	2.7	Cc1ncoc1-c1nnc(SCCCN2CCc3cc4c(cc3CC2)N(C)C(=O)CO4)n1C	10.1016/j.bmcl.2007.12.066
	44454278	95541	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	454	6	1	9	2.7	Cc1ncoc1-c1nnc(SCCCN2CCc3cc4c(cc3CC2)OCC(=O)N4)n1C	10.1016/j.bmcl.2007.12.066
	CHEMBL257536	95541	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	454	6	1	9	2.7	Cc1ncoc1-c1nnc(SCCCN2CCc3cc4c(cc3CC2)OCC(=O)N4)n1C	10.1016/j.bmcl.2007.12.066
	11621352	97633	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	602	7	0	8	6.7	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6oc(C(F)(F)C(F)(F)F)nc6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	CHEMBL271034	97633	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	602	7	0	8	6.7	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6oc(C(F)(F)C(F)(F)F)nc6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	11677768	155574	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	502	6	0	8	4.9	Cc1ccc(-c2nnc(SCCCN3CCc4ccc5oc(C(F)(F)F)nc5c4CC3)n2C)cn1	10.1016/j.bmcl.2007.12.042
	CHEMBL404404	155574	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	502	6	0	8	4.9	Cc1ccc(-c2nnc(SCCCN3CCc4ccc5oc(C(F)(F)F)nc5c4CC3)n2C)cn1	10.1016/j.bmcl.2007.12.042
	44454353	156421	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	483	6	0	8	4.6	Cc1ccc2c(-c3nnc(SCCCN4CCc5nc6ccccn6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	CHEMBL406678	156421	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	483	6	0	8	4.6	Cc1ccc2c(-c3nnc(SCCCN4CCc5nc6ccccn6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	15986135	12329	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilizationAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization	ChEMBL	457	7	0	4	3.7	O=C(c1ccc(F)cc1F)N1CCN(c2ccc(OCCCN3CCCCC3)cc2)C(=O)C1	10.1021/jm0708228
	CHEMBL1185220	12329	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilizationAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization	ChEMBL	457	7	0	4	3.7	O=C(c1ccc(F)cc1F)N1CCN(c2ccc(OCCCN3CCCCC3)cc2)C(=O)C1	10.1021/jm0708228
	CHEMBL398812	12329	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilizationAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization	ChEMBL	457	7	0	4	3.7	O=C(c1ccc(F)cc1F)N1CCN(c2ccc(OCCCN3CCCCC3)cc2)C(=O)C1	10.1021/jm0708228
	15986915	12774	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilizationAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization	ChEMBL	455	7	0	4	4.1	O=C(c1ccc(Cl)cc1)N1CCN(c2ccc(OCCCN3CCCCC3)cc2)C(=O)C1	10.1021/jm0708228
	CHEMBL1187963	12774	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilizationAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization	ChEMBL	455	7	0	4	4.1	O=C(c1ccc(Cl)cc1)N1CCN(c2ccc(OCCCN3CCCCC3)cc2)C(=O)C1	10.1021/jm0708228
	CHEMBL534512	12774	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilizationAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization	ChEMBL	455	7	0	4	4.1	O=C(c1ccc(Cl)cc1)N1CCN(c2ccc(OCCCN3CCCCC3)cc2)C(=O)C1	10.1021/jm0708228
	24749508	12789	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilizationAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization	ChEMBL	446	7	0	5	3.3	N#Cc1ccc(C(=O)N2CCN(c3ccc(OCCCN4CCCCC4)cc3)C(=O)C2)cc1	10.1021/jm0708228
	CHEMBL1188060	12789	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilizationAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization	ChEMBL	446	7	0	5	3.3	N#Cc1ccc(C(=O)N2CCN(c3ccc(OCCCN4CCCCC4)cc3)C(=O)C2)cc1	10.1021/jm0708228
	CHEMBL534958	12789	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilizationAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization	ChEMBL	446	7	0	5	3.3	N#Cc1ccc(C(=O)N2CCN(c3ccc(OCCCN4CCCCC4)cc3)C(=O)C2)cc1	10.1021/jm0708228
	15986914	12858	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilizationAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization	ChEMBL	435	7	0	4	3.7	Cc1ccc(C(=O)N2CCN(c3ccc(OCCCN4CCCCC4)cc3)C(=O)C2)cc1	10.1021/jm0708228
	CHEMBL1188657	12858	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilizationAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization	ChEMBL	435	7	0	4	3.7	Cc1ccc(C(=O)N2CCN(c3ccc(OCCCN4CCCCC4)cc3)C(=O)C2)cc1	10.1021/jm0708228
	CHEMBL536991	12858	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilizationAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization	ChEMBL	435	7	0	4	3.7	Cc1ccc(C(=O)N2CCN(c3ccc(OCCCN4CCCCC4)cc3)C(=O)C2)cc1	10.1021/jm0708228
	15987452	91433	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilizationAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization	ChEMBL	443	7	0	4	3.3	O=C(c1ccc(F)cc1F)N1CCN(c2ccc(OCCCN3CCCC3)cc2)C(=O)C1	10.1021/jm0708228
	CHEMBL240352	91433	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilizationAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization	ChEMBL	443	7	0	4	3.3	O=C(c1ccc(F)cc1F)N1CCN(c2ccc(OCCCN3CCCC3)cc2)C(=O)C1	10.1021/jm0708228
	1524	2181	96	None	-47	18	Human	8.7	pKi	=	8.7	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm300338m
	197	2181	96	None	-47	18	Human	8.7	pKi	=	8.7	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm300338m
	3822	2181	96	None	-47	18	Human	8.7	pKi	=	8.7	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm300338m
	88	2181	96	None	-47	18	Human	8.7	pKi	=	8.7	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm300338m
	CHEMBL51	2181	96	None	-47	18	Human	8.7	pKi	=	8.7	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm300338m
	DB12465	2181	96	None	-47	18	Human	8.7	pKi	=	8.7	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm300338m
	45358442	61323	0	None	-	0	Human	8.6	pKi	=	8.6	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	381	3	0	4	4.3	CN1CCCCC(n2nc(Cc3ccc(Cl)cc3)c3ccccc3c2=O)C1	10.1021/jm1013874
	CHEMBL1767158	61323	0	None	-	0	Human	8.6	pKi	=	8.6	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	381	3	0	4	4.3	CN1CCCCC(n2nc(Cc3ccc(Cl)cc3)c3ccccc3c2=O)C1	10.1021/jm1013874
	53359025	62353	0	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	339	5	1	3	2.5	O=C(CCCN1C2C3C4CC5C6C4C2C6C1(O)C53)c1ccc(F)cc1	10.1016/j.bmcl.2011.04.098
	CHEMBL1779058	62353	0	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	339	5	1	3	2.5	O=C(CCCN1C2C3C4CC5C6C4C2C6C1(O)C53)c1ccc(F)cc1	10.1016/j.bmcl.2011.04.098
	57404031	69710	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	402	7	0	6	4.5	c1ccc(OCCn2c(C3CCCN(Cc4ncco4)C3)nc3ccccc32)cc1	10.1016/j.bmcl.2011.10.115
	CHEMBL1935440	69710	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	402	7	0	6	4.5	c1ccc(OCCn2c(C3CCCN(Cc4ncco4)C3)nc3ccccc32)cc1	10.1016/j.bmcl.2011.10.115
	49836411	18725	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	389	3	1	2	4.8	O=C(O)CC1CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
	CHEMBL1277585	18725	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	389	3	1	2	4.8	O=C(O)CC1CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
	49836295	18766	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	373	2	1	2	4.3	O=C(O)C1=CCCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1277935	18766	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	373	2	1	2	4.3	O=C(O)C1=CCCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	49836187	18797	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	335	4	2	2	3.7	O=C(O)CCNC1CC[C@@]2(Cc3ccccc3Cc3ccccc32)C1	10.1021/jm100856p
	CHEMBL1278115	18797	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	335	4	2	2	3.7	O=C(O)CCNC1CC[C@@]2(Cc3ccccc3Cc3ccccc32)C1	10.1021/jm100856p
	23582308	145864	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	634	14	1	6	6.9	O=C(O)CCc1ccc2cc(Cc3ccccc3)cc(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)c2n1	10.1016/j.bmcl.2016.11.022
	CHEMBL3917428	145864	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	634	14	1	6	6.9	O=C(O)CCc1ccc2cc(Cc3ccccc3)cc(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)c2n1	10.1016/j.bmcl.2016.11.022
	46933089	15733	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assay	ChEMBL	366	4	1	5	2.5	CC(C)(CN1CCN(C2=Cc3ccccc3Cn3ccnc32)CC1)C(=O)O	10.1016/j.bmcl.2010.07.029
	CHEMBL1222554	15733	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assay	ChEMBL	366	4	1	5	2.5	CC(C)(CN1CCN(C2=Cc3ccccc3Cn3ccnc32)CC1)C(=O)O	10.1016/j.bmcl.2010.07.029
	49834051	15747	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assay	ChEMBL	364	3	1	5	2.2	O=C(O)C1CC(N2CCN(C3=Cc4ccccc4Cn4ccnc43)CC2)C1	10.1016/j.bmcl.2010.07.029
	CHEMBL1222626	15747	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assay	ChEMBL	364	3	1	5	2.2	O=C(O)C1CC(N2CCN(C3=Cc4ccccc4Cn4ccnc43)CC2)C1	10.1016/j.bmcl.2010.07.029
	24803482	61333	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	640	14	0	6	7.8	O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1	10.1021/jm1013874
	CHEMBL1767168	61333	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	640	14	0	6	7.8	O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1	10.1021/jm1013874
	11627879	95347	0	None	-	0	Human	6.6	pKi	=	6.6	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	528	6	0	8	4.3	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6c(cc5CC4)N(C)C(=O)CO6)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL256652	95347	0	None	-	0	Human	6.6	pKi	=	6.6	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	528	6	0	8	4.3	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6c(cc5CC4)N(C)C(=O)CO6)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	11577158	97807	0	None	-	0	Human	6.6	pKi	=	6.6	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	514	6	0	8	5.8	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6nc(C)sc6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	CHEMBL271909	97807	0	None	-	0	Human	6.6	pKi	=	6.6	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	514	6	0	8	5.8	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6nc(C)sc6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	134143679	145902	0	None	-	0	Human	6.6	pKi	=	6.6	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	516	10	1	6	4.9	O=C(O)c1ccc2cccc(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)c2n1	10.1016/j.bmcl.2016.11.022
	CHEMBL3917794	145902	0	None	-	0	Human	6.6	pKi	=	6.6	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	516	10	1	6	4.9	O=C(O)c1ccc2cccc(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)c2n1	10.1016/j.bmcl.2016.11.022
	44454120	95172	0	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	438	6	0	9	3.8	Cc1nc2cc3c(cc2o1)CCN(CCCSc1nnc(-c2ocnc2C)n1C)CC3	10.1016/j.bmcl.2007.12.066
	CHEMBL255827	95172	0	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	438	6	0	9	3.8	Cc1nc2cc3c(cc2o1)CCN(CCCSc1nnc(-c2ocnc2C)n1C)CC3	10.1016/j.bmcl.2007.12.066
	11548755	97655	0	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	580	7	0	8	6.8	Cc1ccc2c(-c3nnc(SCCCCN4CCc5cc6nc(C(F)(F)F)oc6c(C)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL271097	97655	0	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	580	7	0	8	6.8	Cc1ccc2c(-c3nnc(SCCCCN4CCc5cc6nc(C(F)(F)F)oc6c(C)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	44454443	97763	0	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	449	6	0	9	3.6	Cc1cnc(-c2nnc(SCCCN3CCc4ccc5c(C)noc5c4CC3)n2C)cn1	10.1016/j.bmcl.2007.12.042
	CHEMBL271702	97763	0	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	449	6	0	9	3.6	Cc1cnc(-c2nnc(SCCCN3CCc4ccc5c(C)noc5c4CC3)n2C)cn1	10.1016/j.bmcl.2007.12.042
	11641596	97798	0	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	484	6	0	8	5.1	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6ncoc6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL271844	97798	0	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	484	6	0	8	5.1	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6ncoc6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	15986645	12870	0	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilizationAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization	ChEMBL	451	5	0	4	3.7	O=C(c1ccc(F)cc1)N1CCN(c2ccc(OC3CCN(C4CCC4)CC3)cc2)C(=O)C1	10.1021/jm0708228
	CHEMBL1188742	12870	0	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilizationAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization	ChEMBL	451	5	0	4	3.7	O=C(c1ccc(F)cc1)N1CCN(c2ccc(OC3CCN(C4CCC4)CC3)cc2)C(=O)C1	10.1021/jm0708228
	CHEMBL537219	12870	0	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilizationAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization	ChEMBL	451	5	0	4	3.7	O=C(c1ccc(F)cc1)N1CCN(c2ccc(OC3CCN(C4CCC4)CC3)cc2)C(=O)C1	10.1021/jm0708228
	44250284	195222	0	None	-	0	Human	8.4	pKi	=	8.4	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	436	6	0	5	4.6	CN(CC1CCOCC1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1	10.1016/j.bmcl.2011.10.115
	CHEMBL550818	195222	0	None	-	0	Human	8.4	pKi	=	8.4	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	436	6	0	5	4.6	CN(CC1CCOCC1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1	10.1016/j.bmcl.2011.10.115
	52944115	18798	0	None	-	0	Human	8.4	pKi	=	8.4	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	291	1	0	1	4.2	CN(C)C1CC[C@]2(Cc3ccccc3Cc3ccccc32)C1	10.1021/jm100856p
	CHEMBL1278116	18798	0	None	-	0	Human	8.4	pKi	=	8.4	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	291	1	0	1	4.2	CN(C)C1CC[C@]2(Cc3ccccc3Cc3ccccc32)C1	10.1021/jm100856p
	49836526	18648	0	None	-	0	Human	7.5	pKi	=	7.5	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	375	3	1	2	4.4	O=C(O)CC1CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1276859	18648	0	None	-	0	Human	7.5	pKi	=	7.5	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	375	3	1	2	4.4	O=C(O)CC1CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	49836528	18658	0	None	-	0	Human	7.5	pKi	=	7.5	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	373	2	1	2	4.0	O=C(O)[C@]12C[C@H]1CN(C1CC[C@]3(Cc4ccccc4Cc4ccccc43)C1)C2	10.1021/jm100856p
	CHEMBL1276947	18658	0	None	-	0	Human	7.5	pKi	=	7.5	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	373	2	1	2	4.0	O=C(O)[C@]12C[C@H]1CN(C1CC[C@]3(Cc4ccccc4Cc4ccccc43)C1)C2	10.1021/jm100856p
	49834052	15746	0	None	-	0	Human	7.5	pKi	=	7.5	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assay	ChEMBL	350	4	1	5	2.0	C=C(CN1CCN(C2=Cc3ccccc3Cn3ccnc32)CC1)C(=O)O	10.1016/j.bmcl.2010.07.029
	CHEMBL1222625	15746	0	None	-	0	Human	7.5	pKi	=	7.5	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assay	ChEMBL	350	4	1	5	2.0	C=C(CN1CCN(C2=Cc3ccccc3Cn3ccnc32)CC1)C(=O)O	10.1016/j.bmcl.2010.07.029
	52937828	61317	0	None	-	0	Human	7.5	pKi	=	7.5	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	347	5	0	4	3.3	CN1CCC[C@@H]1Cn1nc(CCc2ccccc2)c2ccccc2c1=O	10.1021/jm1013874
	CHEMBL1767152	61317	0	None	-	0	Human	7.5	pKi	=	7.5	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	347	5	0	4	3.3	CN1CCC[C@@H]1Cn1nc(CCc2ccccc2)c2ccccc2c1=O	10.1021/jm1013874
	49836634	18666	0	None	-	0	Human	6.5	pKi	=	6.5	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	361	3	1	2	4.0	O=C(O)CC1CN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1277034	18666	0	None	-	0	Human	6.5	pKi	=	6.5	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	361	3	1	2	4.0	O=C(O)CC1CN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	44454434	97907	0	None	-	0	Human	5.5	pKi	=	5.5	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	512	6	0	7	4.5	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6c(cc5CC4)C(=O)N(C)C6)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL272480	97907	0	None	-	0	Human	5.5	pKi	=	5.5	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	512	6	0	7	4.5	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6c(cc5CC4)C(=O)N(C)C6)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	57400502	69713	0	None	-	0	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	321	3	1	4	3.4	Cc1ccc(Cn2c(C3CNCCO3)nc3ccccc32)cc1C	10.1016/j.bmcl.2011.10.115
	CHEMBL1935443	69713	0	None	-	0	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	321	3	1	4	3.4	Cc1ccc(Cn2c(C3CNCCO3)nc3ccccc32)cc1C	10.1016/j.bmcl.2011.10.115
	49836527	18649	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	373	2	1	2	3.9	O=C(O)[C@@H]1[C@H]2CN(C3CCC4(Cc5ccccc5Cc5ccccc54)C3)C[C@H]21	10.1021/jm100856p
	CHEMBL1276860	18649	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	373	2	1	2	3.9	O=C(O)[C@@H]1[C@H]2CN(C3CCC4(Cc5ccccc5Cc5ccccc54)C3)C[C@H]21	10.1021/jm100856p
	49836410	18735	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	393	2	1	2	4.5	O=C(O)C1(F)CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
	CHEMBL1277678	18735	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	393	2	1	2	4.5	O=C(O)C1(F)CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
	49836298	18753	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	373	2	1	2	4.3	O=C(O)C1=CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
	CHEMBL1277854	18753	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	373	2	1	2	4.3	O=C(O)C1=CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
	49836296	18754	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	391	2	1	2	4.5	O=C(O)C1=CCCN(C2CCC3(Cc4cc(F)ccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1277855	18754	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	391	2	1	2	4.5	O=C(O)C1=CCCN(C2CCC3(Cc4cc(F)ccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	57780018	144553	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	544	12	1	6	5.3	O=C(O)CCc1cnc2c(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)cccc2c1	10.1016/j.bmcl.2016.11.022
	CHEMBL3907368	144553	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	544	12	1	6	5.3	O=C(O)CCc1cnc2c(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)cccc2c1	10.1016/j.bmcl.2016.11.022
	49833883	15761	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assay	ChEMBL	394	4	1	5	3.1	Cc1nc2n(c1C)Cc1ccccc1C=C2N1CCN(CC(C)(C)C(=O)O)CC1	10.1016/j.bmcl.2010.07.029
	CHEMBL1222693	15761	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assay	ChEMBL	394	4	1	5	3.1	Cc1nc2n(c1C)Cc1ccccc1C=C2N1CCN(CC(C)(C)C(=O)O)CC1	10.1016/j.bmcl.2010.07.029
	46933090	15776	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assay	ChEMBL	400	4	1	5	3.1	CC(C)(CN1CCN(C2=Cc3ccccc3Cn3c(Cl)cnc32)CC1)C(=O)O	10.1016/j.bmcl.2010.07.029
	CHEMBL1222762	15776	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assay	ChEMBL	400	4	1	5	3.1	CC(C)(CN1CCN(C2=Cc3ccccc3Cn3c(Cl)cnc32)CC1)C(=O)O	10.1016/j.bmcl.2010.07.029
	49834053	15777	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assay	ChEMBL	384	4	1	5	2.6	CC(C)(CN1CCN(C2=Cc3ccccc3Cn3cc(F)nc32)CC1)C(=O)O	10.1016/j.bmcl.2010.07.029
	CHEMBL1222763	15777	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assay	ChEMBL	384	4	1	5	2.6	CC(C)(CN1CCN(C2=Cc3ccccc3Cn3cc(F)nc32)CC1)C(=O)O	10.1016/j.bmcl.2010.07.029
	24803316	61327	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	600	15	1	6	6.9	O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1CCNCCCCc1ccc(OCCCN2CCCCCC2)cc1	10.1021/jm1013874
	CHEMBL1767162	61327	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	600	15	1	6	6.9	O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1CCNCCCCc1ccc(OCCCN2CCCCCC2)cc1	10.1021/jm1013874
	24803480	61328	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	614	15	0	6	7.2	CN(CCCCc1ccc(OCCCN2CCCCCC2)cc1)CCn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/jm1013874
	CHEMBL1767163	61328	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	614	15	0	6	7.2	CN(CCCCc1ccc(OCCCN2CCCCCC2)cc1)CCn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/jm1013874
	11548239	95299	0	None	-	0	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	528	7	0	8	6.1	CCc1nc2ccc3c(c2s1)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.042
	CHEMBL256442	95299	0	None	-	0	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	528	7	0	8	6.1	CCc1nc2ccc3c(c2s1)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.042
	134150412	152102	0	None	-	0	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	516	10	1	6	4.9	O=C(O)c1cnc2c(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)cccc2c1	10.1016/j.bmcl.2016.11.022
	CHEMBL3967709	152102	0	None	-	0	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	516	10	1	6	4.9	O=C(O)c1cnc2c(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)cccc2c1	10.1016/j.bmcl.2016.11.022
	52937632	61308	0	None	-	0	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	389	4	0	4	4.4	CN1CCC[C@@H]1Cn1nc(Cc2ccc(C(C)(C)C)cc2)c2ccccc2c1=O	10.1021/jm1013874
	CHEMBL1767142	61308	0	None	-	0	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	389	4	0	4	4.4	CN1CCC[C@@H]1Cn1nc(Cc2ccc(C(C)(C)C)cc2)c2ccccc2c1=O	10.1021/jm1013874
	11497679	155564	0	None	-	0	Human	5.4	pKi	=	5.4	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	552	6	0	8	6.1	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6nc(C(F)(F)F)oc6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	CHEMBL404363	155564	0	None	-	0	Human	5.4	pKi	=	5.4	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	552	6	0	8	6.1	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6nc(C(F)(F)F)oc6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	57400504	69715	0	None	-	0	Human	8.4	pKi	=	8.4	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	327	3	1	4	3.6	Fc1ccc(Cn2c(C3CNCCS3)nc3ccccc32)cc1	10.1016/j.bmcl.2011.10.115
	CHEMBL1935445	69715	0	None	-	0	Human	8.4	pKi	=	8.4	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	327	3	1	4	3.6	Fc1ccc(Cn2c(C3CNCCS3)nc3ccccc32)cc1	10.1016/j.bmcl.2011.10.115
	57402314	69703	0	None	-	0	Human	8.3	pKi	=	8.3	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	434	5	0	4	4.4	O=C(CN1CCCC(c2nc3ccccc3n2Cc2ccc(F)cc2)C1)N1CCCCC1	10.1016/j.bmcl.2011.10.115
	CHEMBL1935433	69703	0	None	-	0	Human	8.3	pKi	=	8.3	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	434	5	0	4	4.4	O=C(CN1CCCC(c2nc3ccccc3n2Cc2ccc(F)cc2)C1)N1CCCCC1	10.1016/j.bmcl.2011.10.115
	57393573	69709	0	None	-	0	Human	8.3	pKi	=	8.3	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	406	7	0	5	3.4	CN(C)C(=O)CN1CCCC(c2nc3ccccc3n2CCOc2ccccc2)C1	10.1016/j.bmcl.2011.10.115
	CHEMBL1935439	69709	0	None	-	0	Human	8.3	pKi	=	8.3	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	406	7	0	5	3.4	CN(C)C(=O)CN1CCCC(c2nc3ccccc3n2CCOc2ccccc2)C1	10.1016/j.bmcl.2011.10.115
	16681693	82572	1	None	-	0	Human	7.3	pKi	=	7.3	Functional	Antagonist activity at histamine H1 receptor expressed in human PC3 cells inhibition of histamine-induced calcium influx by cell based assayAntagonist activity at histamine H1 receptor expressed in human PC3 cells inhibition of histamine-induced calcium influx by cell based assay	ChEMBL	487	5	1	5	3.6	Cc1ccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)nn1	10.1021/jm300682j
	CHEMBL2178580	82572	1	None	-	0	Human	7.3	pKi	=	7.3	Functional	Antagonist activity at histamine H1 receptor expressed in human PC3 cells inhibition of histamine-induced calcium influx by cell based assayAntagonist activity at histamine H1 receptor expressed in human PC3 cells inhibition of histamine-induced calcium influx by cell based assay	ChEMBL	487	5	1	5	3.6	Cc1ccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)nn1	10.1021/jm300682j
	52937629	61304	0	None	-	0	Human	8.3	pKi	=	8.3	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	377	6	0	5	3.5	CCOc1ccc(Cc2nn(C[C@H]3CCCN3C)c(=O)c3ccccc23)cc1	10.1021/jm1013874
	CHEMBL1767139	61304	0	None	-	0	Human	8.3	pKi	=	8.3	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	377	6	0	5	3.5	CCOc1ccc(Cc2nn(C[C@H]3CCCN3C)c(=O)c3ccccc23)cc1	10.1021/jm1013874
	57395286	69701	0	None	-	0	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	394	5	0	4	3.5	CN(C)C(=O)CN1CCCC(c2nc3ccccc3n2Cc2ccc(F)cc2)C1	10.1016/j.bmcl.2011.10.115
	CHEMBL1935431	69701	0	None	-	0	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	394	5	0	4	3.5	CN(C)C(=O)CN1CCCC(c2nc3ccccc3n2Cc2ccc(F)cc2)C1	10.1016/j.bmcl.2011.10.115
	49836637	18678	0	None	-	0	Human	7.3	pKi	=	7.3	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	375	2	1	3	4.5	O=C(O)C1=CCN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)CC1	10.1021/jm100856p
	CHEMBL1277126	18678	0	None	-	0	Human	7.3	pKi	=	7.3	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	375	2	1	3	4.5	O=C(O)C1=CCN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)CC1	10.1021/jm100856p
	25184832	18695	0	None	-	0	Human	7.3	pKi	=	7.3	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	349	2	1	3	3.8	O=C(O)C1CN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1277312	18695	0	None	-	0	Human	7.3	pKi	=	7.3	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	349	2	1	3	3.8	O=C(O)C1CN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)C1	10.1021/jm100856p
	49836409	18736	0	None	-	0	Human	7.3	pKi	=	7.3	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	391	2	2	3	3.5	O=C(O)C1(O)CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
	CHEMBL1277679	18736	0	None	-	0	Human	7.3	pKi	=	7.3	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	391	2	2	3	3.5	O=C(O)C1(O)CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
	49836300	18743	0	None	-	0	Human	7.3	pKi	=	7.3	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	389	2	1	2	4.8	CC1(C(=O)O)CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
	CHEMBL1277769	18743	0	None	-	0	Human	7.3	pKi	=	7.3	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	389	2	1	2	4.8	CC1(C(=O)O)CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
	49836299	18744	0	None	-	0	Human	7.3	pKi	=	7.3	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	375	2	1	2	4.4	O=C(O)C1CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
	CHEMBL1277770	18744	0	None	-	0	Human	7.3	pKi	=	7.3	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	375	2	1	2	4.4	O=C(O)C1CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
	49834050	15732	0	None	-	0	Human	7.3	pKi	=	7.3	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assay	ChEMBL	338	4	1	5	1.8	O=C(O)CCN1CCN(C2=Cc3ccccc3Cn3ccnc32)CC1	10.1016/j.bmcl.2010.07.029
	CHEMBL1222553	15732	0	None	-	0	Human	7.3	pKi	=	7.3	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assay	ChEMBL	338	4	1	5	1.8	O=C(O)CCN1CCN(C2=Cc3ccccc3Cn3ccnc32)CC1	10.1016/j.bmcl.2010.07.029
	49864885	15744	0	None	-	0	Human	7.3	pKi	=	7.3	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assay	ChEMBL	380	4	1	5	2.9	CC(C)(CN1CCCN(C2=Cc3ccccc3Cn3ccnc32)CC1)C(=O)O	10.1016/j.bmcl.2010.07.029
	CHEMBL1222623	15744	0	None	-	0	Human	7.3	pKi	=	7.3	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assay	ChEMBL	380	4	1	5	2.9	CC(C)(CN1CCCN(C2=Cc3ccccc3Cn3ccnc32)CC1)C(=O)O	10.1016/j.bmcl.2010.07.029
	49833884	15762	0	None	-	0	Human	7.3	pKi	=	7.3	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assay	ChEMBL	380	4	1	5	2.8	Cc1cn2c(n1)C(N1CCN(CC(C)(C)C(=O)O)CC1)=Cc1ccccc1C2	10.1016/j.bmcl.2010.07.029
	CHEMBL1222694	15762	0	None	-	0	Human	7.3	pKi	=	7.3	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assay	ChEMBL	380	4	1	5	2.8	Cc1cn2c(n1)C(N1CCN(CC(C)(C)C(=O)O)CC1)=Cc1ccccc1C2	10.1016/j.bmcl.2010.07.029
	24803641	61324	0	None	-	0	Human	7.3	pKi	=	7.3	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	612	10	0	6	7.5	O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C1CCCN(Cc2ccc(OCCCN3CCCCCC3)cc2)CC1	10.1021/jm1013874
	CHEMBL1767159	61324	0	None	-	0	Human	7.3	pKi	=	7.3	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	612	10	0	6	7.5	O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C1CCCN(Cc2ccc(OCCCN3CCCCCC3)cc2)CC1	10.1021/jm1013874
	11497680	97852	7	None	-	0	Human	6.3	pKi	=	6.3	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	552	6	0	8	6.1	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6oc(C(F)(F)F)nc6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	CHEMBL272150	97852	7	None	-	0	Human	6.3	pKi	=	6.3	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	552	6	0	8	6.1	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6oc(C(F)(F)F)nc6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	11519133	169423	0	None	-	0	Human	6.3	pKi	=	6.3	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	512	7	0	8	5.6	CCc1nc2c3c(ccc2o1)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.042
	CHEMBL442456	169423	0	None	-	0	Human	6.3	pKi	=	6.3	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	512	7	0	8	5.6	CCc1nc2c3c(ccc2o1)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.042
	57398829	69702	0	None	-	0	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	422	7	0	4	4.3	CCN(CC)C(=O)CN1CCCC(c2nc3ccccc3n2Cc2ccc(F)cc2)C1	10.1016/j.bmcl.2011.10.115
	CHEMBL1935432	69702	0	None	-	0	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	422	7	0	4	4.3	CCN(CC)C(=O)CN1CCCC(c2nc3ccccc3n2Cc2ccc(F)cc2)C1	10.1016/j.bmcl.2011.10.115
	49836633	18659	0	None	-	0	Human	8.2	pKi	=	8.2	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	347	2	1	2	3.6	O=C(O)C1CN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1276948	18659	0	None	-	0	Human	8.2	pKi	=	8.2	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	347	2	1	2	3.6	O=C(O)C1CN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	52937119	61320	0	None	-	0	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	367	4	0	4	3.6	CN1CCC(Cn2nc(Cc3ccc(Cl)cc3)c3ccccc3c2=O)C1	10.1021/jm1013874
	CHEMBL1767155	61320	0	None	-	0	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	367	4	0	4	3.6	CN1CCC(Cn2nc(Cc3ccc(Cl)cc3)c3ccccc3c2=O)C1	10.1021/jm1013874
	45272895	195657	18	None	-	0	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	389	4	0	5	4.6	Cc1cnn(C2CCN(c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)c1	10.1016/j.bmcl.2011.10.115
	CHEMBL556450	195657	18	None	-	0	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	389	4	0	5	4.6	Cc1cnn(C2CCN(c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)c1	10.1016/j.bmcl.2011.10.115
	57400503	69714	0	None	-	0	Human	7.2	pKi	=	7.2	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	323	3	1	4	3.8	Cc1ccc(Cn2c(C3CNCCS3)nc3ccccc32)cc1	10.1016/j.bmcl.2011.10.115
	CHEMBL1935444	69714	0	None	-	0	Human	7.2	pKi	=	7.2	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	323	3	1	4	3.8	Cc1ccc(Cn2c(C3CNCCS3)nc3ccccc32)cc1	10.1016/j.bmcl.2011.10.115
	49836414	18794	0	None	-	0	Human	7.2	pKi	=	7.2	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	377	2	1	3	3.4	O=C(O)C1CN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)CCO1	10.1021/jm100856p
	CHEMBL1278112	18794	0	None	-	0	Human	7.2	pKi	=	7.2	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	377	2	1	3	3.4	O=C(O)C1CN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)CCO1	10.1021/jm100856p
	49833882	15760	0	None	-	0	Human	7.2	pKi	=	7.2	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assay	ChEMBL	392	3	1	5	3.0	O=C(O)C1CCC(N2CCN(C3=Cc4ccccc4Cn4ccnc43)CC2)CC1	10.1016/j.bmcl.2010.07.029
	CHEMBL1222692	15760	0	None	-	0	Human	7.2	pKi	=	7.2	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assay	ChEMBL	392	3	1	5	3.0	O=C(O)C1CCC(N2CCN(C3=Cc4ccccc4Cn4ccnc43)CC2)CC1	10.1016/j.bmcl.2010.07.029
	52937223	61322	23	None	-	0	Human	7.2	pKi	=	7.2	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	381	5	0	4	4.1	CN1CCCC1CCn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/jm1013874
	CHEMBL1767157	61322	23	None	-	0	Human	7.2	pKi	=	7.2	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	381	5	0	4	4.1	CN1CCCC1CCn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/jm1013874
	143	3515	51	None	-	0	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	438	5	1	4	4.8	N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2	10.1016/j.bmcl.2007.12.042
	143	3515	51	None	-	0	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	438	5	1	4	4.8	N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2	10.1016/j.bmcl.2007.12.066
	5311096	3515	51	None	-	0	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	438	5	1	4	4.8	N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2	10.1016/j.bmcl.2007.12.042
	5311096	3515	51	None	-	0	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	438	5	1	4	4.8	N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2	10.1016/j.bmcl.2007.12.066
	CHEMBL85606	3515	51	None	-	0	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	438	5	1	4	4.8	N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2	10.1016/j.bmcl.2007.12.042
	CHEMBL85606	3515	51	None	-	0	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	438	5	1	4	4.8	N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2	10.1016/j.bmcl.2007.12.066
	11569996	95312	0	None	-	0	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	525	7	0	8	5.4	CCc1nn(C)c2cc3c(cc12)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.066
	CHEMBL256477	95312	0	None	-	0	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	525	7	0	8	5.4	CCc1nn(C)c2cc3c(cc12)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.066
	11518972	155032	0	None	-	0	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	501	6	0	7	5.5	Cc1noc2cc3c(cc12)CCN(CCCSc1nnc(-c2ccc(C(F)(F)F)cc2)n1C)CC3	10.1016/j.bmcl.2007.12.066
	CHEMBL401576	155032	0	None	-	0	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	501	6	0	7	5.5	Cc1noc2cc3c(cc12)CCN(CCCSc1nnc(-c2ccc(C(F)(F)F)cc2)n1C)CC3	10.1016/j.bmcl.2007.12.066
	52937633	61309	0	None	-	0	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	391	5	0	6	2.9	COC(=O)c1ccc(Cc2nn(C[C@H]3CCCN3C)c(=O)c3ccccc23)cc1	10.1021/jm1013874
	CHEMBL1767143	61309	0	None	-	0	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	391	5	0	6	2.9	COC(=O)c1ccc(Cc2nn(C[C@H]3CCCN3C)c(=O)c3ccccc23)cc1	10.1021/jm1013874
	24803638	61330	0	None	-	0	Human	8.1	pKi	=	8.1	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	636	15	0	7	7.1	COc1ccc(Cc2nn(C[C@H]3CCCN3CCCCc3ccc(OCCCN4CCCCCC4)cc3)c(=O)c3ccccc23)cc1	10.1021/jm1013874
	CHEMBL1767165	61330	0	None	-	0	Human	8.1	pKi	=	8.1	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	636	15	0	7	7.1	COc1ccc(Cc2nn(C[C@H]3CCCN3CCCCc3ccc(OCCCN4CCCCCC4)cc3)c(=O)c3ccccc23)cc1	10.1021/jm1013874
	49836639	18684	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	377	2	1	3	4.6	O=C(O)C1CCN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)CC1	10.1021/jm100856p
	CHEMBL1277216	18684	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	377	2	1	3	4.6	O=C(O)C1CCN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)CC1	10.1021/jm100856p
	49836739	18703	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	387	2	1	3	4.0	O=C(O)C1=CCCN(C2CCC3(C2)C(=O)c2ccccc2Cc2ccccc23)C1	10.1021/jm100856p
	CHEMBL1277400	18703	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	387	2	1	3	4.0	O=C(O)C1=CCCN(C2CCC3(C2)C(=O)c2ccccc2Cc2ccccc23)C1	10.1021/jm100856p
	134139893	146413	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	486	10	0	5	5.6	c1cnc2c(N3CCN(CCCc4ccc(OCCCN5CCCCCC5)cc4)CC3)cccc2c1	10.1016/j.bmcl.2016.11.022
	CHEMBL3921827	146413	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assayAntagonist activity at human Histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced calcium flux preincubated for 30 mins followed by histamine addition by Fluo-4-AM dye based FLIPR assay	ChEMBL	486	10	0	5	5.6	c1cnc2c(N3CCN(CCCc4ccc(OCCCN5CCCCCC5)cc4)CC3)cccc2c1	10.1016/j.bmcl.2016.11.022
	46933091	15763	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assay	ChEMBL	400	4	1	5	3.1	CC(C)(CN1CCN(C2=Cc3ccccc3Cn3cc(Cl)nc32)CC1)C(=O)O	10.1016/j.bmcl.2010.07.029
	CHEMBL1222695	15763	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assay	ChEMBL	400	4	1	5	3.1	CC(C)(CN1CCN(C2=Cc3ccccc3Cn3cc(Cl)nc32)CC1)C(=O)O	10.1016/j.bmcl.2010.07.029
	52937734	61316	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	339	4	0	4	3.6	CN1CCC[C@@H]1Cn1nc(CC2CCCCC2)c2ccccc2c1=O	10.1021/jm1013874
	CHEMBL1767151	61316	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in intact CHO cells assessed as inhibition of histamine-induced cellular calcium mobilization by FLIPR assay	ChEMBL	339	4	0	4	3.6	CN1CCC[C@@H]1Cn1nc(CC2CCCCC2)c2ccccc2c1=O	10.1021/jm1013874
	49836413	18777	0	None	-	0	Human	6.1	pKi	=	6.1	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	393	2	1	2	4.5	O=C(O)C1(F)CCCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1278019	18777	0	None	-	0	Human	6.1	pKi	=	6.1	Functional	Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayAntagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay	ChEMBL	393	2	1	2	4.5	O=C(O)C1(F)CCCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	11584660	93268	8	None	-	5	Human	6.1	pKi	=	6.1	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	537	7	0	8	5.6	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc(-c6cc(C)nn6C)cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	CHEMBL244946	93268	8	None	-	5	Human	6.1	pKi	=	6.1	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	537	7	0	8	5.6	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc(-c6cc(C)nn6C)cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	44454190	98065	0	None	-	0	Human	6.1	pKi	=	6.1	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	537	7	0	8	5.6	Cc1cc2c(-c3nnc(SCCCN4CCc5ccc(-c6cc(C)nn6C)cc5CC4)n3C)cccc2cn1	10.1016/j.bmcl.2007.12.066
	CHEMBL273199	98065	0	None	-	0	Human	6.1	pKi	=	6.1	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	537	7	0	8	5.6	Cc1cc2c(-c3nnc(SCCCN4CCc5ccc(-c6cc(C)nn6C)cc5CC4)n3C)cccc2cn1	10.1016/j.bmcl.2007.12.066
	44454351	160607	0	None	-	0	Human	6.1	pKi	=	6.1	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	551	6	0	8	5.6	Cc1ccc2c(-c3nnc(SCCCN4CCc5nc6cc(C(F)(F)F)ccn6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	CHEMBL411293	160607	0	None	-	0	Human	6.1	pKi	=	6.1	Functional	Antagonist activity at histamine H1 receptor by FLIPR assayAntagonist activity at histamine H1 receptor by FLIPR assay	ChEMBL	551	6	0	8	5.6	Cc1ccc2c(-c3nnc(SCCCN4CCc5nc6cc(C(F)(F)F)ccn6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	57397055	69705	0	None	-	0	Human	8.1	pKi	=	8.1	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	390	5	0	5	4.6	Fc1ccc(Cn2c(C3CCCN(Cc4ncco4)C3)nc3ccccc32)cc1	10.1016/j.bmcl.2011.10.115
	CHEMBL1935435	69705	0	None	-	0	Human	8.1	pKi	=	8.1	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	390	5	0	5	4.6	Fc1ccc(Cn2c(C3CCCN(Cc4ncco4)C3)nc3ccccc32)cc1	10.1016/j.bmcl.2011.10.115
	57395286	69701	0	None	-	0	Human	8.1	pKi	=	8.1	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	394	5	0	4	3.5	CN(C)C(=O)CN1CCCC(c2nc3ccccc3n2Cc2ccc(F)cc2)C1	10.1016/j.bmcl.2011.10.115
	CHEMBL1935431	69701	0	None	-	0	Human	8.1	pKi	=	8.1	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	394	5	0	4	3.5	CN(C)C(=O)CN1CCCC(c2nc3ccccc3n2Cc2ccc(F)cc2)C1	10.1016/j.bmcl.2011.10.115
	57402230	69718	0	None	-	0	Human	7.0	pKi	=	7.0	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	339	4	1	5	3.5	COc1ccc(Cn2c(C3CNCCS3)nc3ccccc32)cc1	10.1016/j.bmcl.2011.10.115
	CHEMBL1935448	69718	0	None	-	0	Human	7.0	pKi	=	7.0	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	339	4	1	5	3.5	COc1ccc(Cn2c(C3CNCCS3)nc3ccccc32)cc1	10.1016/j.bmcl.2011.10.115
	57400504	69715	0	None	-	0	Human	7.0	pKi	=	7.0	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	327	3	1	4	3.6	Fc1ccc(Cn2c(C3CNCCS3)nc3ccccc32)cc1	10.1016/j.bmcl.2011.10.115
	CHEMBL1935445	69715	0	None	-	0	Human	7.0	pKi	=	7.0	Functional	Antagonist activity at histamine H1 receptorAntagonist activity at histamine H1 receptor	ChEMBL	327	3	1	4	3.6	Fc1ccc(Cn2c(C3CNCCS3)nc3ccccc32)cc1	10.1016/j.bmcl.2011.10.115
	2247	505	81	None	-4	42	Human	8.1	pA2	=	8.1	Functional	NoneNone	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	249	505	81	None	-4	42	Human	8.1	pA2	=	8.1	Functional	NoneNone	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	2603	505	81	None	-4	42	Human	8.1	pA2	=	8.1	Functional	NoneNone	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	CHEMBL296419	505	81	None	-4	42	Human	8.1	pA2	=	8.1	Functional	NoneNone	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	DB00637	505	81	None	-4	42	Human	8.1	pA2	=	8.1	Functional	NoneNone	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	1204	1932	119	None	-9	10	Rat	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	1247	1932	119	None	-9	10	Rat	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	1375	1932	119	None	-9	10	Rat	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	774	1932	119	None	-9	10	Rat	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	CHEMBL90	1932	119	None	-9	10	Rat	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	DB05381	1932	119	None	-9	10	Rat	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	1204	1932	119	None	-3	10	Guinea pig	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	1247	1932	119	None	-3	10	Guinea pig	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	1375	1932	119	None	-3	10	Guinea pig	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	774	1932	119	None	-3	10	Guinea pig	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	CHEMBL90	1932	119	None	-3	10	Guinea pig	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	DB05381	1932	119	None	-3	10	Guinea pig	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	1427	2013	54	None	5	30	Rat	8.0	pIC50	=	8.0	Functional	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	Drug Central	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	357	2013	54	None	5	30	Rat	8.0	pIC50	=	8.0	Functional	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	Drug Central	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	3696	2013	54	None	5	30	Rat	8.0	pIC50	=	8.0	Functional	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	Drug Central	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	CHEMBL11	2013	54	None	5	30	Rat	8.0	pIC50	=	8.0	Functional	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	Drug Central	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	DB00458	2013	54	None	5	30	Rat	8.0	pIC50	=	8.0	Functional	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	Drug Central	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	1971	2866	38	None	6	32	Rat	8.0	pIC50	=	8.0	Functional	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
	2404	2866	38	None	6	32	Rat	8.0	pIC50	=	8.0	Functional	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
	4543	2866	38	None	6	32	Rat	8.0	pIC50	=	8.0	Functional	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
	CHEMBL445	2866	38	None	6	32	Rat	8.0	pIC50	=	8.0	Functional	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
	DB00540	2866	38	None	6	32	Rat	8.0	pIC50	=	8.0	Functional	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
	180	401	56	None	3	38	Rat	8.0	pIC50	=	8.0	Functional	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	200	401	56	None	3	38	Rat	8.0	pIC50	=	8.0	Functional	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	2160	401	56	None	3	38	Rat	8.0	pIC50	=	8.0	Functional	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	CHEMBL629	401	56	None	3	38	Rat	8.0	pIC50	=	8.0	Functional	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	DB00321	401	56	None	3	38	Rat	8.0	pIC50	=	8.0	Functional	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	40466858	16155	67	None	-5	4	Guinea pig	8.3	pIC50	=	8.3	Functional	Inhibition of H1 receptor in Cavia porcellus Hartley (guinea pig) ileum assessed as inhibition of histamine-induced spasms incubated 2 min prior histamine-challengeInhibition of H1 receptor in Cavia porcellus Hartley (guinea pig) ileum assessed as inhibition of histamine-induced spasms incubated 2 min prior histamine-challenge	Drug Central	348	6	1	3	4.0	Cc1ccc(/C(=C\CN2CCCC2)c2cccc(/C=C/C(=O)O)n2)cc1	None
	5284514	16155	67	None	-5	4	Guinea pig	8.3	pIC50	=	8.3	Functional	Inhibition of H1 receptor in Cavia porcellus Hartley (guinea pig) ileum assessed as inhibition of histamine-induced spasms incubated 2 min prior histamine-challengeInhibition of H1 receptor in Cavia porcellus Hartley (guinea pig) ileum assessed as inhibition of histamine-induced spasms incubated 2 min prior histamine-challenge	Drug Central	348	6	1	3	4.0	Cc1ccc(/C(=C\CN2CCCC2)c2cccc(/C=C/C(=O)O)n2)cc1	None
	CHEMBL1224	16155	67	None	-5	4	Guinea pig	8.3	pIC50	=	8.3	Functional	Inhibition of H1 receptor in Cavia porcellus Hartley (guinea pig) ileum assessed as inhibition of histamine-induced spasms incubated 2 min prior histamine-challengeInhibition of H1 receptor in Cavia porcellus Hartley (guinea pig) ileum assessed as inhibition of histamine-induced spasms incubated 2 min prior histamine-challenge	Drug Central	348	6	1	3	4.0	Cc1ccc(/C(=C\CN2CCCC2)c2cccc(/C=C/C(=O)O)n2)cc1	None
	1599	2341	50	None	-3	21	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	None
	3955	2341	50	None	-3	21	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	None
	7215	2341	50	None	-3	21	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	None
	CHEMBL841	2341	50	None	-3	21	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	None
	DB00836	2341	50	None	-3	21	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	None
	4223	3992	94	None	-199	16	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	6918314	3992	94	None	-199	16	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	7427	3992	94	None	-199	16	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	CHEMBL439849	3992	94	None	-199	16	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	DB06684	3992	94	None	-199	16	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	40466858	16155	67	None	5	4	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	348	6	1	3	4.0	Cc1ccc(/C(=C\CN2CCCC2)c2cccc(/C=C/C(=O)O)n2)cc1	None
	5284514	16155	67	None	5	4	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	348	6	1	3	4.0	Cc1ccc(/C(=C\CN2CCCC2)c2cccc(/C=C/C(=O)O)n2)cc1	None
	CHEMBL1224	16155	67	None	5	4	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	348	6	1	3	4.0	Cc1ccc(/C(=C\CN2CCCC2)c2cccc(/C=C/C(=O)O)n2)cc1	None
	2762	3863	31	None	100	9	Human	8.1	pIC50	=	8.1	Functional	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	Drug Central	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	None
	5587	3863	31	None	100	9	Human	8.1	pIC50	=	8.1	Functional	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	Drug Central	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	None
	7318	3863	31	None	100	9	Human	8.1	pIC50	=	8.1	Functional	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	Drug Central	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	None
	CHEMBL1241	3863	31	None	100	9	Human	8.1	pIC50	=	8.1	Functional	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	Drug Central	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	None
	DB00792	3863	31	None	100	9	Human	8.1	pIC50	=	8.1	Functional	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	Drug Central	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	None
	1427	2013	54	None	-19	30	Human	8.1	pIC50	=	8.1	Functional	NoneNone	Drug Central	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	357	2013	54	None	-19	30	Human	8.1	pIC50	=	8.1	Functional	NoneNone	Drug Central	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	3696	2013	54	None	-19	30	Human	8.1	pIC50	=	8.1	Functional	NoneNone	Drug Central	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	CHEMBL11	2013	54	None	-19	30	Human	8.1	pIC50	=	8.1	Functional	NoneNone	Drug Central	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	DB00458	2013	54	None	-19	30	Human	8.1	pIC50	=	8.1	Functional	NoneNone	Drug Central	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	2337	3256	77	None	-1	29	Human	8.1	pIC50	=	8.1	Functional	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3256	77	None	-1	29	Human	8.1	pIC50	=	8.1	Functional	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3256	77	None	-1	29	Human	8.1	pIC50	=	8.1	Functional	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3256	77	None	-1	29	Human	8.1	pIC50	=	8.1	Functional	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3256	77	None	-1	29	Human	8.1	pIC50	=	8.1	Functional	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	10103	3416	72	None	28	2	Human	8.1	pIC50	=	8.1	Functional	Inhibitory concentration against histamine H1 receptorInhibitory concentration against histamine H1 receptor	Drug Central	415	2	0	3	5.6	Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	None
	133017	3416	72	None	28	2	Human	8.1	pIC50	=	8.1	Functional	Inhibitory concentration against histamine H1 receptorInhibitory concentration against histamine H1 receptor	Drug Central	415	2	0	3	5.6	Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	None
	2413	3416	72	None	28	2	Human	8.1	pIC50	=	8.1	Functional	Inhibitory concentration against histamine H1 receptorInhibitory concentration against histamine H1 receptor	Drug Central	415	2	0	3	5.6	Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	None
	CHEMBL91397	3416	72	None	28	2	Human	8.1	pIC50	=	8.1	Functional	Inhibitory concentration against histamine H1 receptorInhibitory concentration against histamine H1 receptor	Drug Central	415	2	0	3	5.6	Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	None
	DB11614	3416	72	None	28	2	Human	8.1	pIC50	=	8.1	Functional	Inhibitory concentration against histamine H1 receptorInhibitory concentration against histamine H1 receptor	Drug Central	415	2	0	3	5.6	Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	None
	1027	1576	73	None	6	7	Guinea pig	8.1	pIC50	=	8.1	Functional	Potency against histamine H1 receptor on guinea pig ileumPotency against histamine H1 receptor on guinea pig ileum	Drug Central	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	None
	3241	1576	73	None	6	7	Guinea pig	8.1	pIC50	=	8.1	Functional	Potency against histamine H1 receptor on guinea pig ileumPotency against histamine H1 receptor on guinea pig ileum	Drug Central	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	None
	7176	1576	73	None	6	7	Guinea pig	8.1	pIC50	=	8.1	Functional	Potency against histamine H1 receptor on guinea pig ileumPotency against histamine H1 receptor on guinea pig ileum	Drug Central	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	None
	CHEMBL1106	1576	73	None	6	7	Guinea pig	8.1	pIC50	=	8.1	Functional	Potency against histamine H1 receptor on guinea pig ileumPotency against histamine H1 receptor on guinea pig ileum	Drug Central	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	None
	DB00751	1576	73	None	6	7	Guinea pig	8.1	pIC50	=	8.1	Functional	Potency against histamine H1 receptor on guinea pig ileumPotency against histamine H1 receptor on guinea pig ileum	Drug Central	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	None
	1224	1432	83	None	85	22	Guinea pig	8.1	pIC50	=	8.1	Functional	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	3100	1432	83	None	85	22	Guinea pig	8.1	pIC50	=	8.1	Functional	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	8980	1432	83	None	85	22	Guinea pig	8.1	pIC50	=	8.1	Functional	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	916	1432	83	None	85	22	Guinea pig	8.1	pIC50	=	8.1	Functional	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	CHEMBL657	1432	83	None	85	22	Guinea pig	8.1	pIC50	=	8.1	Functional	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	DB01075	1432	83	None	85	22	Guinea pig	8.1	pIC50	=	8.1	Functional	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	2995	204405	53	None	2	18	Rat	8.0	pIC50	=	8.0	Functional	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	CHEMBL1696	204405	53	None	2	18	Rat	8.0	pIC50	=	8.0	Functional	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	CHEMBL72	204405	53	None	2	18	Rat	8.0	pIC50	=	8.0	Functional	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	2398	954	62	None	2	36	Rat	8.0	pIC50	=	8.0	Functional	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
	2801	954	62	None	2	36	Rat	8.0	pIC50	=	8.0	Functional	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
	701	954	62	None	2	36	Rat	8.0	pIC50	=	8.0	Functional	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
	CHEMBL415	954	62	None	2	36	Rat	8.0	pIC50	=	8.0	Functional	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
	DB01242	954	62	None	2	36	Rat	8.0	pIC50	=	8.0	Functional	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
	4223	3992	94	None	-199	16	Human	6.5	pIC50	=	6.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	15341484
	6918314	3992	94	None	-199	16	Human	6.5	pIC50	=	6.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	15341484
	7427	3992	94	None	-199	16	Human	6.5	pIC50	=	6.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	15341484
	CHEMBL439849	3992	94	None	-199	16	Human	6.5	pIC50	=	6.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	15341484
	DB06684	3992	94	None	-199	16	Human	6.5	pIC50	=	6.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	15341484
	2762	3863	31	None	100	9	Human	7.4	pIC50	=	7.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	14667234
	5587	3863	31	None	100	9	Human	7.4	pIC50	=	7.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	14667234
	7318	3863	31	None	100	9	Human	7.4	pIC50	=	7.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	14667234
	CHEMBL1241	3863	31	None	100	9	Human	7.4	pIC50	=	7.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	14667234
	DB00792	3863	31	None	100	9	Human	7.4	pIC50	=	7.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	14667234
	10103	3416	72	None	28	2	Human	8.4	pIC50	=	8.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	415	2	0	3	5.6	Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	16220969
	133017	3416	72	None	28	2	Human	8.4	pIC50	=	8.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	415	2	0	3	5.6	Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	16220969
	2413	3416	72	None	28	2	Human	8.4	pIC50	=	8.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	415	2	0	3	5.6	Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	16220969
	CHEMBL91397	3416	72	None	28	2	Human	8.4	pIC50	=	8.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	415	2	0	3	5.6	Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	16220969
	DB11614	3416	72	None	28	2	Human	8.4	pIC50	=	8.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	415	2	0	3	5.6	Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	16220969

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Similar- ity	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
		3158	56267	27	None	40	20	Human	9.0	pAC50	=	9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1628227	56267	27	None	40	20	Human	9.0	pAC50	=	9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
		135	2532	43	None	-1	58	Human	8.7	pAC50	=	8.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		1796	2532	43	None	-1	58	Human	8.7	pAC50	=	8.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		4184	2532	43	None	-1	58	Human	8.7	pAC50	=	8.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		CHEMBL6437	2532	43	None	-1	58	Human	8.7	pAC50	=	8.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		DB06148	2532	43	None	-1	58	Human	8.7	pAC50	=	8.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		3121	7885	104	None	-	0	Human	7.0	pAC50	=	7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	144	5	1	1	2.3	CCCC(CCC)C(=O)O	10.1038/s41467-023-40064-9
		CHEMBL109	7885	104	None	-	0	Human	7.0	pAC50	=	7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	144	5	1	1	2.3	CCCC(CCC)C(=O)O	10.1038/s41467-023-40064-9
		CHEMBL433	7885	104	None	-	0	Human	7.0	pAC50	=	7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	144	5	1	1	2.3	CCCC(CCC)C(=O)O	10.1038/s41467-023-40064-9
		213	3853	55	None	-8	44	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
		2717	3853	55	None	-8	44	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
		5533	3853	55	None	-8	44	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
		CHEMBL621	3853	55	None	-8	44	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
		DB00656	3853	55	None	-8	44	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
		3689	102771	55	None	-	0	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL1372983	102771	55	None	-	0	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL305187	102771	55	None	-	0	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
		42890	9425	59	None	-	0	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	497	3	5	10	1.0	CC(=O)[C@]1(O)Cc2c(O)c3c(c(O)c2[C@@H](O[C@H]2C[C@H](N)[C@H](O)[C@H](C)O2)C1)C(=O)c1ccccc1C3=O	10.1038/s41467-023-40064-9
		CHEMBL1117	9425	59	None	-	0	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	497	3	5	10	1.0	CC(=O)[C@]1(O)Cc2c(O)c3c(c(O)c2[C@@H](O[C@H]2C[C@H](N)[C@H](O)[C@H](C)O2)C1)C(=O)c1ccccc1C3=O	10.1038/s41467-023-40064-9
		44139752	104284	45	None	-	0	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	227	1	0	3	2.4	N#Cc1ccc([C@H]2CCc3cncn32)c(F)c1	10.1038/s41467-023-40064-9
		CHEMBL3099695	104284	45	None	-	0	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	227	1	0	3	2.4	N#Cc1ccc([C@H]2CCc3cncn32)c(F)c1	10.1038/s41467-023-40064-9
		2477	745	59	None	-	29	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
		36	745	59	None	-	29	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
		437	745	59	None	-	29	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
		CHEMBL49	745	59	None	-	29	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
		DB00490	745	59	None	-	29	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
		11693	1827	16	None	-	5	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		3494	1827	16	None	-	5	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		4302	1827	16	None	-	5	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		7459	1827	16	None	-	5	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		CHEMBL1201335	1827	16	None	-	5	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		DB00986	1827	16	None	-	5	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		5048	3133	64	None	-109	7	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	10.1038/s41467-023-40064-9
		8924	3133	64	None	-109	7	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	10.1038/s41467-023-40064-9
		9948102	3133	64	None	-109	7	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	10.1038/s41467-023-40064-9
		CHEMBL462605	3133	64	None	-109	7	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	10.1038/s41467-023-40064-9
		DB11642	3133	64	None	-109	7	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	10.1038/s41467-023-40064-9
		4846	27987	53	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	308	1	2	6	2.2	O=C(O)c1cc(O)c2c3nc4ccccc4oc-3cc(=O)c2n1	10.1038/s41467-023-40064-9
		CHEMBL1372341	27987	53	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	308	1	2	6	2.2	O=C(O)c1cc(O)c2c3nc4ccccc4oc-3cc(=O)c2n1	10.1038/s41467-023-40064-9
		5284632	67402	13	None	-	5	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1888176	67402	13	None	-	5	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL3084748	67402	13	None	-	5	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		1549120	196486	85	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	319	4	1	4	2.9	CC(/C=C1\SC(=S)N(CC(=O)O)C1=O)=C\c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL56337	196486	85	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	319	4	1	4	2.9	CC(/C=C1\SC(=S)N(CC(=O)O)C1=O)=C\c1ccccc1	10.1038/s41467-023-40064-9
		2600	3779	74	None	1	13	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		2608	3779	74	None	1	13	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		5405	3779	74	None	1	13	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		CHEMBL17157	3779	74	None	1	13	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		DB00342	3779	74	None	1	13	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		2564	206184	51	None	-2	3	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	290	6	0	3	3.4	CN(C)CCOC(c1ccc(Cl)cc1)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL864	206184	51	None	-2	3	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	290	6	0	3	3.4	CN(C)CCOC(c1ccc(Cl)cc1)c1ccccn1	10.1038/s41467-023-40064-9
		6337614	12996	54	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	296	1	0	2	2.7	O=C1c2cccc3c2[C@H](CCC3)CN1[C@@H]1CN2CCC1CC2	10.1038/s41467-023-40064-9
		CHEMBL1189679	12996	54	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	296	1	0	2	2.7	O=C1c2cccc3c2[C@H](CCC3)CN1[C@@H]1CN2CCC1CC2	10.1038/s41467-023-40064-9
		4260	52558	31	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	279	6	0	4	3.0	CC(=O)Oc1cc(C(C)C)c(OCCN(C)C)cc1C	10.1038/s41467-023-40064-9
		CHEMBL159226	52558	31	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	279	6	0	4	3.0	CC(=O)Oc1cc(C(C)C)c(OCCN(C)C)cc1C	10.1038/s41467-023-40064-9
		4034	55822	55	None	-	1	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
		CHEMBL1623	55822	55	None	-	1	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
		5656	203066	87	None	-79	40	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	10.1038/s41467-023-40064-9
		CHEMBL637	203066	87	None	-79	40	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	10.1038/s41467-023-40064-9
		214	3860	58	None	-43	30	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		2740	3860	58	None	-43	30	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		5566	3860	58	None	-43	30	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		66064	3860	58	None	-43	30	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		CHEMBL422	3860	58	None	-43	30	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		DB00831	3860	58	None	-43	30	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		367	3824	12	None	-	8	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
		5487427	3824	12	None	-	8	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
		8592	3824	12	None	-	8	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
		CHEMBL1900528	3824	12	None	-	8	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
		CHEMBL3305968	3824	12	None	-	8	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
		CHEMBL4650755	3824	12	None	-	8	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
		DB01409	3824	12	None	-	8	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
		2218	15283	23	None	-	0	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	322	8	0	2	4.4	CCN(CC)CCCN(c1ccccc1)C1Cc2ccccc2C1	10.1038/s41467-023-40064-9
		CHEMBL1213033	15283	23	None	-	0	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	322	8	0	2	4.4	CCN(CC)CCCN(c1ccccc1)C1Cc2ccccc2C1	10.1038/s41467-023-40064-9
		1613	2348	53	None	-3	44	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		205	2348	53	None	-3	44	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		3964	2348	53	None	-3	44	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		CHEMBL831	2348	53	None	-3	44	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		DB00408	2348	53	None	-3	44	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		1170	1633	75	None	-	1	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1038/s41467-023-40064-9
		3348	1633	75	None	-	1	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1038/s41467-023-40064-9
		4819	1633	75	None	-	1	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1038/s41467-023-40064-9
		74685737	1633	75	None	-	1	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1038/s41467-023-40064-9
		CHEMBL914	1633	75	None	-	1	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1038/s41467-023-40064-9
		DB00950	1633	75	None	-	1	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1038/s41467-023-40064-9
		260	3869	54	None	-	5	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	284	2	1	3	3.0	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		2775	3869	54	None	-	5	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	284	2	1	3	3.0	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		656665	3869	54	None	-	5	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	284	2	1	3	3.0	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL56564	3869	54	None	-	5	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	284	2	1	3	3.0	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		DB11699	3869	54	None	-	5	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	284	2	1	3	3.0	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		3149	12614	15	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1187011	12614	15	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
		7029	13669	19	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	205	5	0	2	2.6	CCN(CC)C(C)C(=O)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1194666	13669	19	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	205	5	0	2	2.6	CCN(CC)C(C)C(=O)c1ccccc1	10.1038/s41467-023-40064-9
		11980903	14492	19	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
		22526	14492	19	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
		5281035	14492	19	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1201303	14492	19	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
		54841	203127	52	None	-2	27	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL641	203127	52	None	-2	27	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	10.1038/s41467-023-40064-9
		10531	1420	21	None	-	23	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		121	1420	21	None	-	23	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		888	1420	21	None	-	23	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		CHEMBL1732	1420	21	None	-	23	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		DB00320	1420	21	None	-	23	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		135398747	33453	24	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	137	1	1	2	0.3	C[n+]1ccccc1C=NO	10.1038/s41467-023-40064-9
		135484646	33453	24	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	137	1	1	2	0.3	C[n+]1ccccc1C=NO	10.1038/s41467-023-40064-9
		4884	33453	24	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	137	1	1	2	0.3	C[n+]1ccccc1C=NO	10.1038/s41467-023-40064-9
		CHEMBL1420	33453	24	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	137	1	1	2	0.3	C[n+]1ccccc1C=NO	10.1038/s41467-023-40064-9
		180	401	56	None	-1	40	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		200	401	56	None	-1	40	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		2160	401	56	None	-1	40	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL629	401	56	None	-1	40	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		DB00321	401	56	None	-1	40	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		124087	1389	114	None	3	15	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		7157	1389	114	None	3	15	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		814	1389	114	None	3	15	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		CHEMBL1172	1389	114	None	3	15	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		DB00967	1389	114	None	3	15	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		1201549	597	24	None	-1	20	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		333	597	24	None	-1	20	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		7601	597	24	None	-1	20	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1201203	597	24	None	-1	20	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL438151	597	24	None	-1	20	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		DB00245	597	24	None	-1	20	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		2318	154856	29	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL400599	154856	29	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
		2402	3370	62	None	-	24	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
		5095	3370	62	None	-	24	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
		7295	3370	62	None	-	24	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
		CHEMBL589	3370	62	None	-	24	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
		DB00268	3370	62	None	-	24	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
		2274	3173	58	None	-3	31	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		4917	3173	58	None	-3	31	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		7279	3173	58	None	-3	31	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		CHEMBL728	3173	58	None	-3	31	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		DB00433	3173	58	None	-3	31	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		2995	204405	53	None	-14	23	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1696	204405	53	None	-14	23	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL72	204405	53	None	-14	23	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
		16362	3125	71	None	-489	30	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		2172	3125	71	None	-489	30	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		90	3125	71	None	-489	30	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL1423	3125	71	None	-489	30	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		DB01100	3125	71	None	-489	30	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		2470	3653	50	None	-4570	59	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		3300	3653	50	None	-4570	59	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		5265	3653	50	None	-4570	59	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		99	3653	50	None	-4570	59	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL267930	3653	50	None	-4570	59	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		10007	14484	38	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	183	2	1	1	2.6	CC(C)(N)Cc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		CHEMBL1201269	14484	38	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	183	2	1	1	2.6	CC(C)(N)Cc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		20628	96548	28	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	324	6	1	5	3.7	CN(C)CCCNc1c2ccccc2nc2cccc([N+](=O)[O-])c12	10.1038/s41467-023-40064-9
		CHEMBL26291	96548	28	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	324	6	1	5	3.7	CN(C)CCCNc1c2ccccc2nc2cccc([N+](=O)[O-])c12	10.1038/s41467-023-40064-9
		5365247	138429	33	None	-	1	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	316	4	0	2	3.8	CN(C)C/C=C(/c1ccc(Br)cc1)c1cccnc1	10.1038/s41467-023-40064-9
		CHEMBL37744	138429	33	None	-	1	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	316	4	0	2	3.8	CN(C)C/C=C(/c1ccc(Br)cc1)c1cccnc1	10.1038/s41467-023-40064-9
		21772	78399	31	None	-	0	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	293	4	0	1	4.5	CC(CC1c2ccccc2CCc2ccccc21)CN(C)C	10.1038/s41467-023-40064-9
		CHEMBL2110816	78399	31	None	-	0	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	293	4	0	1	4.5	CC(CC1c2ccccc2CCc2ccccc21)CN(C)C	10.1038/s41467-023-40064-9
		228	445	28	None	-	24	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
		33	445	28	None	-	24	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
		6005	445	28	None	-	24	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
		CHEMBL53	445	28	None	-	24	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
		DB00714	445	28	None	-	24	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
		2264	53190	38	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	349	2	1	4	1.5	CN1C(=O)COc2c(C(=O)NC3CN4CCC3CC4)cc(Cl)cc21	10.1038/s41467-023-40064-9
		CHEMBL1598608	53190	38	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	349	2	1	4	1.5	CN1C(=O)COc2c(C(=O)NC3CN4CCC3CC4)cc(Cl)cc21	10.1038/s41467-023-40064-9
		CHEMBL5292015	194537	0	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	398	6	1	3	3.6	C[N@+]1(CCF)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(O)(c1ccccc1)c1ccccc1)C2	10.1038/s41467-023-40064-9
		55483	205097	40	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	356	13	4	4	3.6	Oc1ccc(CCNCCCCCCNCCc2ccccc2)cc1O	10.1038/s41467-023-40064-9
		CHEMBL77622	205097	40	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	356	13	4	4	3.6	Oc1ccc(CCNCCCCCCNCCc2ccccc2)cc1O	10.1038/s41467-023-40064-9
		4066	204626	78	None	-1	7	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
		CHEMBL73451	204626	78	None	-1	7	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
		156419	938	74	None	-	1	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
		3308	938	74	None	-	1	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
		647	938	74	None	-	1	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
		CHEMBL1201284	938	74	None	-	1	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
		DB01012	938	74	None	-	1	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
		3042	1414	35	None	-	14	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
		355	1414	35	None	-	14	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
		868	1414	35	None	-	14	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
		CHEMBL1123	1414	35	None	-	14	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
		DB00804	1414	35	None	-	14	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
		2169	44847	35	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	380	9	3	6	1.4	COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1	10.1038/s41467-023-40064-9
		CHEMBL152231	44847	35	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	380	9	3	6	1.4	COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1	10.1038/s41467-023-40064-9
		1427	2013	54	None	-5	27	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		357	2013	54	None	-5	27	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		3696	2013	54	None	-5	27	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL11	2013	54	None	-5	27	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		DB00458	2013	54	None	-5	27	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		40466858	16155	67	None	-	0	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	348	6	1	3	4.0	Cc1ccc(/C(=C\CN2CCCC2)c2cccc(/C=C/C(=O)O)n2)cc1	10.1038/s41467-023-40064-9
		5284514	16155	67	None	-	0	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	348	6	1	3	4.0	Cc1ccc(/C(=C\CN2CCCC2)c2cccc(/C=C/C(=O)O)n2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1224	16155	67	None	-	0	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	348	6	1	3	4.0	Cc1ccc(/C(=C\CN2CCCC2)c2cccc(/C=C/C(=O)O)n2)cc1	10.1038/s41467-023-40064-9
		5440	28724	37	None	-1	9	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
		CHEMBL1378	28724	37	None	-1	9	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
		2142	3096	58	None	-263	36	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
		4920903	3096	58	None	-263	36	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
		502	3096	58	None	-263	36	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
		5775	3096	58	None	-263	36	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
		CHEMBL597	3096	58	None	-263	36	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
		DB00692	3096	58	None	-263	36	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
		4632	56058	115	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	228	3	1	3	2.6	COc1ccc(C(=O)c2ccccc2)c(O)c1	10.1038/s41467-023-40064-9
		CHEMBL1625	56058	115	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	228	3	1	3	2.6	COc1ccc(C(=O)c2ccccc2)c(O)c1	10.1038/s41467-023-40064-9
		3704	78189	41	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	231	3	1	3	1.6	C1=Cc2cccc(OCC3CNCCO3)c2C1	10.1038/s41467-023-40064-9
		CHEMBL2105022	78189	41	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	231	3	1	3	1.6	C1=Cc2cccc(OCC3CNCCO3)c2C1	10.1038/s41467-023-40064-9
		4942	5718	50	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	367	7	0	4	4.0	CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1078261	5718	50	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	367	7	0	4	4.0	CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		1971	2866	38	None	-1	30	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
		2404	2866	38	None	-1	30	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
		4543	2866	38	None	-1	30	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL445	2866	38	None	-1	30	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
		DB00540	2866	38	None	-1	30	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
		1228	3866	34	None	-5	4	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	10.1038/s41467-023-40064-9
		2763	3866	34	None	-5	4	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	10.1038/s41467-023-40064-9
		5282443	3866	34	None	-5	4	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL855	3866	34	None	-5	4	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	10.1038/s41467-023-40064-9
		DB00427	3866	34	None	-5	4	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	10.1038/s41467-023-40064-9
		1605	2342	117	None	-2	4	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1038/s41467-023-40064-9
		3957	2342	117	None	-2	4	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1038/s41467-023-40064-9
		7216	2342	117	None	-2	4	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1038/s41467-023-40064-9
		CHEMBL998	2342	117	None	-2	4	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1038/s41467-023-40064-9
		DB00455	2342	117	None	-2	4	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1038/s41467-023-40064-9
		30323	62485	57	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	527	4	5	11	1.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
		CHEMBL1563	62485	57	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	527	4	5	11	1.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
		CHEMBL178	62485	57	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	527	4	5	11	1.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
		2812	4779	101	None	-28	34	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	10.1038/s41467-023-40064-9
		CHEMBL104	4779	101	None	-28	34	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	10.1038/s41467-023-40064-9
		72093	35061	9	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
		CHEMBL1433361	35061	9	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
		CHEMBL2103773	35061	9	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
		5284550	41721	15	None	-1	9	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1492500	41721	15	None	-1	9	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
		4640	78266	30	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	379	6	1	4	3.9	COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC	10.1038/s41467-023-40064-9
		CHEMBL2107011	78266	30	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	379	6	1	4	3.9	COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC	10.1038/s41467-023-40064-9
		2771	195017	74	None	-2	27	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
		CHEMBL1200781	195017	74	None	-2	27	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
		CHEMBL549	195017	74	None	-2	27	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
		46780481	107531	20	None	-13	53	Human	8.7	pAC50	=	8.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
		9903970	107531	20	None	-13	53	Human	8.7	pAC50	=	8.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
		CHEMBL3187365	107531	20	None	-13	53	Human	8.7	pAC50	=	8.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
		CHEMBL3544974	107531	20	None	-13	53	Human	8.7	pAC50	=	8.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
		1210	918	51	None	-20	21	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		1213	918	51	None	-20	21	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		2725	918	51	None	-20	21	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		33036	918	51	None	-20	21	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		4411	918	51	None	-20	21	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		616	918	51	None	-20	21	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		6976	918	51	None	-20	21	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		716121	918	51	None	-20	21	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		CHEMBL1201353	918	51	None	-20	21	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		CHEMBL1554789	918	51	None	-20	21	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		CHEMBL505	918	51	None	-20	21	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		DB01114	918	51	None	-20	21	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		DB13679	918	51	None	-20	21	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		16351	102730	47	None	-	6	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL304902	102730	47	None	-	6	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
		225609	14452	56	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	422	3	2	6	2.4	CC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C	10.1038/s41467-023-40064-9
		CHEMBL1201010	14452	56	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	422	3	2	6	2.4	CC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C	10.1038/s41467-023-40064-9
		216416	111581	48	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
		CHEMBL328190	111581	48	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
		2895	203592	41	None	-1	8	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL669	203592	41	None	-1	8	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
		1524	2181	96	None	-2	52	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
		197	2181	96	None	-2	52	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
		3822	2181	96	None	-2	52	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
		88	2181	96	None	-2	52	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
		CHEMBL51	2181	96	None	-2	52	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
		DB12465	2181	96	None	-2	52	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
		2601	3780	33	None	-	21	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
		443951	3780	33	None	-	21	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
		56	3780	33	None	-	21	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
		CHEMBL73151	3780	33	None	-	21	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
		DB13399	3780	33	None	-	21	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
		6729	14485	41	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	432	5	0	2	6.5	CC(C)(C)c1ccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1201271	14485	41	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	432	5	0	2	6.5	CC(C)(C)c1ccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)cc1	10.1038/s41467-023-40064-9
		24826799	10798	104	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
		CHEMBL1171837	10798	104	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
		107771	120248	49	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	517	7	2	7	6.1	COc1ccc2nc3cc(Cl)ccc3c(Nc3cc(CN4CCCC4)c(O)c(CN4CCCC4)c3)c2n1	10.1038/s41467-023-40064-9
		CHEMBL35228	120248	49	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	517	7	2	7	6.1	COc1ccc2nc3cc(Cl)ccc3c(Nc3cc(CN4CCCC4)c(O)c(CN4CCCC4)c3)c2n1	10.1038/s41467-023-40064-9
		240	944	43	None	-	24	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
		2769	944	43	None	-	24	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
		44279790	944	43	None	-	24	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
		660	944	43	None	-	24	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
		CHEMBL1729	944	43	None	-	24	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
		CHEMBL560739	944	43	None	-	24	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
		DB00604	944	43	None	-	24	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
		104850	3330	96	None	-	5	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
		4150	3330	96	None	-	5	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
		743	3330	96	None	-	5	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
		CHEMBL111	3330	96	None	-	5	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
		DB06155	3330	96	None	-	5	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
		444	206666	53	None	-2089	18	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	239	3	1	2	3.3	CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1	10.1038/s41467-023-40064-9
		CHEMBL894	206666	53	None	-2089	18	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	239	3	1	2	3.3	CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1	10.1038/s41467-023-40064-9
		2726	919	68	None	-2	72	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		621	919	68	None	-2	72	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		83	919	68	None	-2	72	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		CHEMBL71	919	68	None	-2	72	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		DB00477	919	68	None	-2	72	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		21722	17992	31	None	1	6	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	10.1038/s41467-023-40064-9
		CHEMBL126224	17992	31	None	1	6	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	10.1038/s41467-023-40064-9
		2200	20203	61	None	-	2	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1256819	20203	61	None	-	2	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1305	20203	61	None	-	2	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		1164	1630	26	None	-	12	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	336	6	0	2	4.1	CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1	10.1038/s41467-023-40064-9
		1626	1630	26	None	-	12	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	336	6	0	2	4.1	CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1	10.1038/s41467-023-40064-9
		3345	1630	26	None	-	12	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	336	6	0	2	4.1	CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL596	1630	26	None	-	12	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	336	6	0	2	4.1	CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1	10.1038/s41467-023-40064-9
		DB00813	1630	26	None	-	12	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	336	6	0	2	4.1	CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1	10.1038/s41467-023-40064-9
		46220502	112583	84	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	506	7	1	8	4.9	CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL3301610	112583	84	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	506	7	1	8	4.9	CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1	10.1038/s41467-023-40064-9
		68617	205527	62	None	-1023	26	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1709	205527	62	None	-1023	26	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL809	205527	62	None	-1023	26	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
		176	398	66	None	-	31	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
		2157	398	66	None	-	31	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
		2566	398	66	None	-	31	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
		CHEMBL633	398	66	None	-	31	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
		DB01118	398	66	None	-	31	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
		2381	663	48	None	-	8	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1038/s41467-023-40064-9
		374	663	48	None	-	8	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1038/s41467-023-40064-9
		7128	663	48	None	-	8	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1038/s41467-023-40064-9
		CHEMBL1101	663	48	None	-	8	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1038/s41467-023-40064-9
		DB00810	663	48	None	-	8	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1038/s41467-023-40064-9
		2267	559	71	None	10	7	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
		271	559	71	None	10	7	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
		7121	559	71	None	10	7	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
		CHEMBL639	559	71	None	10	7	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
		DB00972	559	71	None	10	7	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
		2865	4143	73	None	-58	53	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		59	4143	73	None	-58	53	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		60854	4143	73	None	-58	53	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL708	4143	73	None	-58	53	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		DB00246	4143	73	None	-58	53	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		65709	59881	39	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	365	8	0	5	3.3	CCN(CC)CCn1c(=O)c(Cc2ccc(OC)cc2)nc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1729803	59881	39	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	365	8	0	5	3.3	CCN(CC)CCn1c(=O)c(Cc2ccc(OC)cc2)nc2ccccc21	10.1038/s41467-023-40064-9
		71481097	120510	48	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	443	5	2	7	3.4	O=C(/C=C\n1cnc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1)NNc1cnccn1	10.1038/s41467-023-40064-9
		CHEMBL3545185	120510	48	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	443	5	2	7	3.4	O=C(/C=C\n1cnc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1)NNc1cnccn1	10.1038/s41467-023-40064-9
		2337	3256	77	None	1	62	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		50	3256	77	None	1	62	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		5002	3256	77	None	1	62	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL716	3256	77	None	1	62	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		DB01224	3256	77	None	1	62	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		150	2509	21	None	-	16	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
		1764	2509	21	None	-	16	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
		8226	2509	21	None	-	16	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
		CHEMBL1201356	2509	21	None	-	16	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
		DB00353	2509	21	None	-	16	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
		2389	3331	118	None	-46	67	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		5073	3331	118	None	-46	67	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		96	3331	118	None	-46	67	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		CHEMBL85	3331	118	None	-46	67	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		DB00734	3331	118	None	-46	67	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		4832	55420	17	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	354	5	1	3	3.1	CC[N+]1(C)CCCC(OC(=O)C(O)(c2ccccc2)c2ccccc2)C1	10.1038/s41467-023-40064-9
		CHEMBL1619528	55420	17	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	354	5	1	3	3.1	CC[N+]1(C)CCCC(OC(=O)C(O)(c2ccccc2)c2ccccc2)C1	10.1038/s41467-023-40064-9
		68867	78173	38	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	402	7	2	6	3.1	CCOc1cc(N)c([N+](=O)[O-])cc1C(=O)NC1CCN(CC2CC=CCC2)CC1	10.1038/s41467-023-40064-9
		CHEMBL2104523	78173	38	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	402	7	2	6	3.1	CCOc1cc(N)c([N+](=O)[O-])cc1C(=O)NC1CCN(CC2CC=CCC2)CC1	10.1038/s41467-023-40064-9
		60065	84369	6	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	505	7	1	8	4.2	COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@@H]2CCCN(Cc3ccccc3)C2)C1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
		CHEMBL2218858	84369	6	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	505	7	1	8	4.2	COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@@H]2CCCN(Cc3ccccc3)C2)C1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
		146570	43454	67	None	-1	4	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	324	5	0	3	3.8	CN(C)CCC[C@@]1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
		CHEMBL1508	43454	67	None	-1	4	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	324	5	0	3	3.8	CN(C)CCC[C@@]1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
		1212	1662	50	None	-41	65	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		204	1662	50	None	-41	65	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		3372	1662	50	None	-41	65	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		CHEMBL726	1662	50	None	-41	65	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		DB00623	1662	50	None	-41	65	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		5311507	194815	41	None	-	1	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	400	5	1	4	4.2	OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL53904	194815	41	None	-	1	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	400	5	1	4	4.2	OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
		55645	84370	8	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
		CHEMBL2218861	84370	8	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
		11658860	2344	51	None	-	3	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
		2941	2344	51	None	-	3	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
		4374	2344	51	None	-	3	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
		CHEMBL360328	2344	51	None	-	3	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
		DB04871	2344	51	None	-	3	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
		4046	2483	33	None	-	2	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
		4252	2483	33	None	-	2	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
		CHEMBL416956	2483	33	None	-	2	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
		DB00358	2483	33	None	-	2	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
		104870	98880	47	None	-	21	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	10.1038/s41467-023-40064-9
		5374	98880	47	None	-	21	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	10.1038/s41467-023-40064-9
		CHEMBL279085	98880	47	None	-	21	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	10.1038/s41467-023-40064-9
		3081361	93934	123	None	-	0	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
		CHEMBL24828	93934	123	None	-	0	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
		2540	4401	111	None	-	4	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1014	4401	111	None	-	4	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
		6127	14499	8	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL1201340	14499	8	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		179	400	115	None	-4365	49	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1038/s41467-023-40064-9
		2159	400	115	None	-4365	49	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1038/s41467-023-40064-9
		963	400	115	None	-4365	49	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1038/s41467-023-40064-9
		CHEMBL243712	400	115	None	-4365	49	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1038/s41467-023-40064-9
		DB06288	400	115	None	-4365	49	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1038/s41467-023-40064-9
		131411	15392	70	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	476	7	1	6	5.2	CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12	10.1038/s41467-023-40064-9
		28446253	15392	70	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	476	7	1	6	5.2	CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12	10.1038/s41467-023-40064-9
		CHEMBL1214598	15392	70	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	476	7	1	6	5.2	CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12	10.1038/s41467-023-40064-9
		CHEMBL2103737	78140	0	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
		4528	98126	80	None	-1	10	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	238	1	1	2	2.8	CN1Cc2c(N)cccc2C(c2ccccc2)C1	10.1038/s41467-023-40064-9
		CHEMBL273575	98126	80	None	-1	10	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	238	1	1	2	2.8	CN1Cc2c(N)cccc2C(c2ccccc2)C1	10.1038/s41467-023-40064-9
		2284	3182	33	None	1	29	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		4926	3182	33	None	1	29	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		7281	3182	33	None	1	29	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL564	3182	33	None	1	29	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		DB00420	3182	33	None	1	29	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		26987	949	33	None	16	21	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		6063	949	33	None	16	21	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		671	949	33	None	16	21	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		CHEMBL1626	949	33	None	16	21	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		DB00283	949	33	None	16	21	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		2782	32000	67	None	-	1	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	325	4	0	3	4.3	Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1	10.1038/s41467-023-40064-9
		CHEMBL1407943	32000	67	None	-	1	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	325	4	0	3	4.3	Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1	10.1038/s41467-023-40064-9
		CHEMBL3216363	32000	67	None	-	1	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	325	4	0	3	4.3	Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1	10.1038/s41467-023-40064-9
		2136	3095	30	None	-	6	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
		4768	3095	30	None	-	6	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
		7268	3095	30	None	-	6	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL753	3095	30	None	-	6	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
		DB00925	3095	30	None	-	6	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
		4614	5391	103	None	-	0	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	293	5	1	3	4.0	O=C(O)CCc1nc(-c2ccccc2)c(-c2ccccc2)o1	10.1038/s41467-023-40064-9
		CHEMBL1071	5391	103	None	-	0	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	293	5	1	3	4.0	O=C(O)CCc1nc(-c2ccccc2)c(-c2ccccc2)o1	10.1038/s41467-023-40064-9
		1224	1432	83	None	-2	13	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		3100	1432	83	None	-2	13	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		8980	1432	83	None	-2	13	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		916	1432	83	None	-2	13	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		CHEMBL657	1432	83	None	-2	13	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		DB01075	1432	83	None	-2	13	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		1210	918	51	None	-20	21	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		1213	918	51	None	-20	21	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		2725	918	51	None	-20	21	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		33036	918	51	None	-20	21	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		4411	918	51	None	-20	21	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		616	918	51	None	-20	21	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		6976	918	51	None	-20	21	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		716121	918	51	None	-20	21	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		CHEMBL1201353	918	51	None	-20	21	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		CHEMBL1554789	918	51	None	-20	21	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		CHEMBL505	918	51	None	-20	21	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		DB01114	918	51	None	-20	21	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		DB13679	918	51	None	-20	21	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		1547484	940	74	None	-1	20	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		654	940	74	None	-1	20	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		9072	940	74	None	-1	20	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL43064	940	74	None	-1	20	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		DB00568	940	74	None	-1	20	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		9429	202133	58	None	-	5	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL609109	202133	58	None	-	5	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
		5329102	194726	86	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
		CHEMBL535	194726	86	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
		154417	23181	60	None	-	5	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	289	4	1	4	1.9	CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)[C@H](CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
		CHEMBL1331216	23181	60	None	-	5	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	289	4	1	4	1.9	CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)[C@H](CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
		4940	14470	35	None	-	0	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	340	5	0	4	4.8	CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
		CHEMBL1201210	14470	35	None	-	0	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	340	5	0	4	4.8	CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
		1385580	29276	76	None	-1	5	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		4615	29276	76	None	-1	5	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL13828	29276	76	None	-1	5	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		19675	51670	43	None	-	0	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	410	7	1	5	5.0	CC(=O)c1ccc2c(c1)N(CCCN1CCC(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
		CHEMBL1584	51670	43	None	-	0	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	410	7	1	5	5.0	CC(=O)c1ccc2c(c1)N(CCCN1CCC(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
		65700	78260	28	None	-	0	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	238	1	1	2	3.3	CNC1Cc2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL2106919	78260	28	None	-	0	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	238	1	1	2	3.3	CNC1Cc2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
		212	3806	47	None	-5	25	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		2639	3806	47	None	-5	25	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		941651	3806	47	None	-5	25	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		CHEMBL1201	3806	47	None	-5	25	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		DB01623	3806	47	None	-5	25	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		25382	9157	37	None	-	0	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL110094	9157	37	None	-	0	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
		4008	7226	92	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	610	10	1	9	5.0	COC(=O)C1=C(C)NC(C)=C(C(=O)OCCN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
		CHEMBL1085699	7226	92	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	610	10	1	9	5.0	COC(=O)C1=C(C)NC(C)=C(C(=O)OCCN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
		1400	1957	70	None	2	3	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		3658	1957	70	None	2	3	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		7199	1957	70	None	2	3	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		91513	1957	70	None	2	3	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL896	1957	70	None	2	3	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		DB00557	1957	70	None	2	3	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		3151	1462	97	None	-41	27	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		945	1462	97	None	-41	27	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		965	1462	97	None	-41	27	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL219916	1462	97	None	-41	27	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		DB01184	1462	97	None	-41	27	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL4743867	214033	14	None	-	0	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL		None	None	None		OCCN1CCN(CCC=C2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1	10.1038/s41467-023-40064-9
		135398737	958	93	None	2	89	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		38	958	93	None	2	89	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		722	958	93	None	2	89	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL42	958	93	None	2	89	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		DB00363	958	93	None	2	89	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		2220	3134	82	None	-	14	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		27400	3134	82	None	-	14	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		93	3134	82	None	-	14	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		CHEMBL294951	3134	82	None	-	14	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		DB06153	3134	82	None	-	14	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		2705	3842	64	None	-	10	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
		360	3842	64	None	-	10	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
		443879	3842	64	None	-	10	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
		CHEMBL1382	3842	64	None	-	10	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
		DB01036	3842	64	None	-	10	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
		1890	2759	49	None	-44	16	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
		4449	2759	49	None	-44	16	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
		7247	2759	49	None	-44	16	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
		CHEMBL623	2759	49	None	-44	16	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
		DB01149	2759	49	None	-44	16	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
		209	3057	97	None	-11	23	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		2113	3057	97	None	-11	23	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		4748	3057	97	None	-11	23	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		CHEMBL567	3057	97	None	-11	23	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		DB00850	3057	97	None	-11	23	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		1209	1658	75	None	-144	32	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
		203	1658	75	None	-144	32	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
		3386	1658	75	None	-144	32	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
		CHEMBL41	1658	75	None	-144	32	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
		DB00472	1658	75	None	-144	32	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
		242	470	124	None	-22	51	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		34	470	124	None	-22	51	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		60795	470	124	None	-22	51	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		CHEMBL1112	470	124	None	-22	51	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		DB01238	470	124	None	-22	51	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		4452	2762	19	None	-	19	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
		983	2762	19	None	-	19	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
		CHEMBL20734	2762	19	None	-	19	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
		2407	3372	76	None	-	7	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
		59227	3372	76	None	-	7	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
		941	3372	76	None	-	7	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
		CHEMBL1303	3372	76	None	-	7	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
		DB05271	3372	76	None	-	7	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
		5639	98895	75	None	-	5	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	387	7	1	8	0.7	COc1ccccc1N1CCN(CCCNc2cc(=O)n(C)c(=O)n2C)CC1	10.1038/s41467-023-40064-9
		CHEMBL279229	98895	75	None	-	5	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	387	7	1	8	0.7	COc1ccccc1N1CCN(CCCNc2cc(=O)n(C)c(=O)n2C)CC1	10.1038/s41467-023-40064-9
		3294	2006	111	None	-14	45	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		71360	2006	111	None	-14	45	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		87	2006	111	None	-14	45	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		CHEMBL14376	2006	111	None	-14	45	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		DB04946	2006	111	None	-14	45	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		134	2514	24	None	-933	67	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
		1775	2514	24	None	-933	67	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
		9681	2514	24	None	-933	67	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
		CHEMBL1065	2514	24	None	-933	67	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
		DB00247	2514	24	None	-933	67	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
		11434515	261	6	None	-	5	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
		11519741	261	6	None	-	5	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
		4484	261	6	None	-	5	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
		7449	261	6	None	-	5	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
		CHEMBL1194325	261	6	None	-	5	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
		DB08897	261	6	None	-	5	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
		4756	16649	50	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	213	2	2	5	2.7	Nc1ccc(/N=N/c2ccccc2)c(N)n1	10.1038/s41467-023-40064-9
		CHEMBL1201022	16649	50	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	213	2	2	5	2.7	Nc1ccc(/N=N/c2ccccc2)c(N)n1	10.1038/s41467-023-40064-9
		CHEMBL1242	16649	50	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	213	2	2	5	2.7	Nc1ccc(/N=N/c2ccccc2)c(N)n1	10.1038/s41467-023-40064-9
		3949	100614	50	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	468	8	0	5	4.9	COc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c(OC)c1OC	10.1038/s41467-023-40064-9
		CHEMBL29188	100614	50	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	468	8	0	5	4.9	COc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c(OC)c1OC	10.1038/s41467-023-40064-9
		29566	78204	82	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	284	2	2	6	-2.7	O=S1(=O)CCN(CN2CCS(=O)(=O)NC2)CN1	10.1038/s41467-023-40064-9
		CHEMBL2105420	78204	82	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	284	2	2	6	-2.7	O=S1(=O)CCN(CN2CCS(=O)(=O)NC2)CN1	10.1038/s41467-023-40064-9
		17676	7072	29	None	-	3	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
		5281082	7072	29	None	-	3	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
		CHEMBL1085	7072	29	None	-	3	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
		19910	37408	106	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	190	1	1	4	1.8	O=[N+]([O-])c1ccc(O)c2ncccc12	10.1038/s41467-023-40064-9
		CHEMBL1454910	37408	106	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	190	1	1	4	1.8	O=[N+]([O-])c1ccc(O)c2ncccc12	10.1038/s41467-023-40064-9
		4976	203579	29	None	-1	12	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL668	203579	29	None	-1	12	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
		2105	3054	37	None	-	33	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		47811	3054	37	None	-	33	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		48	3054	37	None	-	33	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		CHEMBL531	3054	37	None	-	33	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		DB01186	3054	37	None	-	33	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		6834	205552	45	None	-1	2	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	318	5	0	2	3.9	CN(C)CCC(c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL811	205552	45	None	-1	2	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	318	5	0	2	3.9	CN(C)CCC(c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
		7045767	59108	27	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	203	5	0	4	-1.2	CC(=O)O[C@H](CC(=O)[O-])C[N+](C)(C)C	10.1038/s41467-023-40064-9
		CHEMBL1697733	59108	27	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	203	5	0	4	-1.2	CC(=O)O[C@H](CC(=O)[O-])C[N+](C)(C)C	10.1038/s41467-023-40064-9
		11949652	80512	60	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	426	4	1	7	1.6	Cc1cc(N2CCN([C@@H]3CN[C@H](C(=O)N4CCSC4)C3)CC2)n(-c2ccccc2)n1	10.1038/s41467-023-40064-9
		CHEMBL2147777	80512	60	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	426	4	1	7	1.6	Cc1cc(N2CCN([C@@H]3CN[C@H](C(=O)N4CCSC4)C3)CC2)n(-c2ccccc2)n1	10.1038/s41467-023-40064-9
		44093	48931	94	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	217	3	2	3	0.6	C[C@H](CS)C(=O)N1CCC[C@H]1C(=O)O	10.1038/s41467-023-40064-9
		CHEMBL1560	48931	94	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	217	3	2	3	0.6	C[C@H](CS)C(=O)N1CCC[C@H]1C(=O)O	10.1038/s41467-023-40064-9
		2393	3334	82	None	-	5	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
		5078	3334	82	None	-	5	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
		51	3334	82	None	-	5	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
		CHEMBL905	3334	82	None	-	5	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
		DB00953	3334	82	None	-	5	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
		16960	14487	23	None	-	0	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	318	5	0	2	3.9	CN(C)CC[C@@H](c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL1201287	14487	23	None	-	0	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	318	5	0	2	3.9	CN(C)CC[C@@H](c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
		1816	2540	102	None	-3	18	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
		4205	2540	102	None	-3	18	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
		7241	2540	102	None	-3	18	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
		CHEMBL654	2540	102	None	-3	18	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
		DB00370	2540	102	None	-3	18	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
		19861	207523	50	None	-	1	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL946	207523	50	None	-	1	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
		3926	207241	40	None	-	0	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	491	9	1	3	5.8	Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL92870	207241	40	None	-	0	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	491	9	1	3	5.8	Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
		146015336	53348	111	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	252	2	2	2	2.0	O=C1N=C(O)NC1(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		1775	53348	111	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	252	2	2	2	2.0	O=C1N=C(O)NC1(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL16	53348	111	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	252	2	2	2	2.0	O=C1N=C(O)NC1(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1611	53348	111	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	252	2	2	2	2.0	O=C1N=C(O)NC1(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		1353	1911	93	None	-489	83	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		3559	1911	93	None	-489	83	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		86	1911	93	None	-489	83	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		CHEMBL54	1911	93	None	-489	83	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		DB00502	1911	93	None	-489	83	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		5453	203619	102	None	-	0	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	189	3	0	1	0.2	S=P(N1CC1)(N1CC1)N1CC1	10.1038/s41467-023-40064-9
		CHEMBL671	203619	102	None	-	0	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	189	3	0	1	0.2	S=P(N1CC1)(N1CC1)N1CC1	10.1038/s41467-023-40064-9
		2435	3590	83	None	-95	48	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
		60149	3590	83	None	-95	48	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
		98	3590	83	None	-95	48	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
		CHEMBL12713	3590	83	None	-95	48	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
		DB06144	3590	83	None	-95	48	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
		65866	94264	73	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	611	12	1	8	6.5	COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)CN(C)CCC(c2ccccc2)c2ccccc2)C1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
		CHEMBL250270	94264	73	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	611	12	1	8	6.5	COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)CN(C)CCC(c2ccccc2)c2ccccc2)C1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
		4450	178228	69	None	-	3	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	253	1	0	2	3.2	CN1CCOC(c2ccccc2)c2ccccc2C1	10.1038/s41467-023-40064-9
		CHEMBL465026	178228	69	None	-	3	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	253	1	0	2	3.2	CN1CCOC(c2ccccc2)c2ccccc2C1	10.1038/s41467-023-40064-9
		3947	206395	53	None	-7	16	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		CHEMBL87708	206395	53	None	-7	16	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		2398	954	62	None	-1	29	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		2801	954	62	None	-1	29	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		701	954	62	None	-1	29	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		CHEMBL415	954	62	None	-1	29	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		DB01242	954	62	None	-1	29	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		191	403	98	None	-56	29	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		201	403	98	None	-56	29	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		2170	403	98	None	-56	29	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		CHEMBL1113	403	98	None	-56	29	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		DB00543	403	98	None	-56	29	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		37	778	60	None	-	17	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		460	778	60	None	-	17	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		54746	778	60	None	-	17	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		CHEMBL1201087	778	60	None	-	17	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		DB00248	778	60	None	-	17	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		5904	100392	40	None	-	1	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	334	4	2	4	0.9	CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)O	10.1038/s41467-023-40064-9
		CHEMBL1223	100392	40	None	-	1	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	334	4	2	4	0.9	CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)O	10.1038/s41467-023-40064-9
		CHEMBL29	100392	40	None	-	1	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	334	4	2	4	0.9	CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)O	10.1038/s41467-023-40064-9
		2286	3183	51	None	-2	30	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		4927	3183	51	None	-2	30	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		7282	3183	51	None	-2	30	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		CHEMBL643	3183	51	None	-2	30	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		DB01069	3183	51	None	-2	30	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		103	4153	61	None	-1	53	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		2875	4153	61	None	-1	53	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		5736	4153	61	None	-1	53	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		CHEMBL285802	4153	61	None	-1	53	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		DB09225	4153	61	None	-1	53	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		4011	82408	49	None	6	24	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	10.1038/s41467-023-40064-9
		CHEMBL21731	82408	49	None	6	24	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	10.1038/s41467-023-40064-9
		16363	596	53	None	-	7	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		312	596	53	None	-	7	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		9215	596	53	None	-	7	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL297302	596	53	None	-	7	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		DB12867	596	53	None	-	7	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		4418	34222	85	None	-	6	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
		CHEMBL142635	34222	85	None	-	6	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
		4020	205150	39	None	-	1	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	284	1	1	3	2.6	OC1(c2ccc(Cl)cc2)c2ccccc2C2=NCCN21	10.1038/s41467-023-40064-9
		CHEMBL781	205150	39	None	-	1	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	284	1	1	3	2.6	OC1(c2ccc(Cl)cc2)c2ccccc2C2=NCCN21	10.1038/s41467-023-40064-9
		23480	124090	23	None	-	0	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	281	5	1	1	5.0	CC(CC(c1ccccc1)c1ccccc1)NC(C)(C)C	10.1038/s41467-023-40064-9
		CHEMBL363295	124090	23	None	-	0	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	281	5	1	1	5.0	CC(CC(c1ccccc1)c1ccccc1)NC(C)(C)C	10.1038/s41467-023-40064-9
		1222	881	0	None	-1	2	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		2678	881	0	None	-1	2	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		581	881	0	None	-1	2	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1000	881	0	None	-1	2	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		DB00341	881	0	None	-1	2	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		9801	91585	35	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	329	8	1	1	5.4	CC(Cc1ccccc1)NCCC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL24072	91585	35	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	329	8	1	1	5.4	CC(Cc1ccccc1)NCCC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		5411	204033	89	None	-	2	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	264	8	1	4	2.6	CCCCNc1ccc(C(=O)OCCN(C)C)cc1	10.1038/s41467-023-40064-9
		CHEMBL698	204033	89	None	-	2	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	264	8	1	4	2.6	CCCCNc1ccc(C(=O)OCCN(C)C)cc1	10.1038/s41467-023-40064-9
		135398745	2914	112	None	1	65	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		47	2914	112	None	1	65	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL715	2914	112	None	1	65	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		DB00334	2914	112	None	1	65	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		2762	3863	31	None	-9	2	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
		5587	3863	31	None	-9	2	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
		7318	3863	31	None	-9	2	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
		CHEMBL1241	3863	31	None	-9	2	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
		DB00792	3863	31	None	-9	2	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
		2247	505	81	None	-4	42	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		249	505	81	None	-4	42	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		2603	505	81	None	-4	42	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		CHEMBL296419	505	81	None	-4	42	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		DB00637	505	81	None	-4	42	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		9417	133512	54	None	-	0	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL1524185	133512	54	None	-	0	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL370753	133512	54	None	-	0	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
		11291	98796	25	None	-	2	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	261	1	0	1	3.9	CN1CCC2=C(C1)C(c1ccccc1)c1ccccc12	10.1038/s41467-023-40064-9
		CHEMBL278398	98796	25	None	-	2	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	261	1	0	1	3.9	CN1CCC2=C(C1)C(c1ccccc1)c1ccccc12	10.1038/s41467-023-40064-9
		2712	916	34	None	-5	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	299	1	1	3	3.0	CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl	10.1038/s41467-023-40064-9
		3370	916	34	None	-5	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	299	1	1	3	3.0	CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl	10.1038/s41467-023-40064-9
		594	916	34	None	-5	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	299	1	1	3	3.0	CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl	10.1038/s41467-023-40064-9
		CHEMBL451	916	34	None	-5	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	299	1	1	3	3.0	CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl	10.1038/s41467-023-40064-9
		DB00475	916	34	None	-5	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	299	1	1	3	3.0	CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl	10.1038/s41467-023-40064-9
		1193	1656	108	None	-	0	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	281	3	2	2	4.1	OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
		2447	1656	108	None	-	0	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	281	3	2	2	4.1	OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
		3371	1656	108	None	-	0	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	281	3	2	2	4.1	OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
		CHEMBL23588	1656	108	None	-	0	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	281	3	2	2	4.1	OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
		DB02266	1656	108	None	-	0	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	281	3	2	2	4.1	OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
		135564886	14493	5	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
		135673376	14493	5	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
		137157436	14493	5	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
		145948239	14493	5	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
		71587099	14493	5	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
		CHEMBL1201304	14493	5	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
		1222	1664	49	None	-17	33	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		3396	1664	49	None	-17	33	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		85	1664	49	None	-17	33	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL46516	1664	49	None	-17	33	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		DB04842	1664	49	None	-17	33	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		3180	14473	41	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	289	8	0	3	3.9	CCCCOc1ccc(C(=O)CCN2CCCCC2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1201217	14473	41	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	289	8	0	3	3.9	CCCCOc1ccc(C(=O)CCN2CCCCC2)cc1	10.1038/s41467-023-40064-9
		2794	19380	85	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	472	4	1	4	7.5	CC(C)/N=c1\cc2n(-c3ccc(Cl)cc3)c3ccccc3nc-2cc1Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		CHEMBL1292	19380	85	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	472	4	1	4	7.5	CC(C)/N=c1\cc2n(-c3ccc(Cl)cc3)c3ccccc3nc-2cc1Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		5284616	161627	55	None	-	0	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	914	6	3	13	6.2	CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](O)[C@H](OC)C2)CC(=O)[C@H](C)/C=C(\C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)/C=C/C=C/C=C/1C	10.1038/s41467-023-40064-9
		CHEMBL413	161627	55	None	-	0	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	914	6	3	13	6.2	CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](O)[C@H](OC)C2)CC(=O)[C@H](C)/C=C(\C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)/C=C/C=C/C=C/1C	10.1038/s41467-023-40064-9
		2351	4300	49	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
		CHEMBL1008	4300	49	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
		CHEMBL1257078	4300	49	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
		213046	2385	59	None	-	9	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		4168	2385	59	None	-	9	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		7461	2385	59	None	-	9	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		CHEMBL1237021	2385	59	None	-	9	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		DB08815	2385	59	None	-	9	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		135398735	136968	32	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	822	4	6	15	4.3	CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C	10.1038/s41467-023-40064-9
		136262914	136968	32	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	822	4	6	15	4.3	CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C	10.1038/s41467-023-40064-9
		CHEMBL374478	136968	32	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	822	4	6	15	4.3	CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C	10.1038/s41467-023-40064-9
		202	1508	77	None	-1	30	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		60835	1508	77	None	-1	30	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		972	1508	77	None	-1	30	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL1175	1508	77	None	-1	30	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		DB00476	1508	77	None	-1	30	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		2335	11848	22	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		8478	11848	22	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1182210	11848	22	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL221753	11848	22	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		3547	141373	71	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	291	2	1	4	1.2	O=S(=O)(c1cccc2cnccc12)N1CCCNCC1	10.1038/s41467-023-40064-9
		CHEMBL38380	141373	71	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	291	2	1	4	1.2	O=S(=O)(c1cccc2cnccc12)N1CCCNCC1	10.1038/s41467-023-40064-9
		CHEMBL541388	141373	71	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	291	2	1	4	1.2	O=S(=O)(c1cccc2cnccc12)N1CCCNCC1	10.1038/s41467-023-40064-9
		2179	167518	76	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	393	5	2	5	4.5	COc1cc(NS(C)(=O)=O)ccc1Nc1c2ccccc2nc2ccccc12	10.1038/s41467-023-40064-9
		CHEMBL1256655	167518	76	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	393	5	2	5	4.5	COc1cc(NS(C)(=O)=O)ccc1Nc1c2ccccc2nc2ccccc12	10.1038/s41467-023-40064-9
		CHEMBL43	167518	76	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	393	5	2	5	4.5	COc1cc(NS(C)(=O)=O)ccc1Nc1c2ccccc2nc2ccccc12	10.1038/s41467-023-40064-9
		100	3805	58	None	-7	55	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		2637	3805	58	None	-7	55	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		5452	3805	58	None	-7	55	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		CHEMBL479	3805	58	None	-7	55	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		DB00679	3805	58	None	-7	55	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		2448	99323	70	None	-4	18	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	10.1038/s41467-023-40064-9
		CHEMBL28218	99323	70	None	-4	18	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	10.1038/s41467-023-40064-9
		4642	41986	28	None	-	0	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	344	5	1	5	2.7	CN1CCCN=C1COC(=O)C(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
		CHEMBL1495	41986	28	None	-	0	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human HRH1 in an in vitro assay measured by filtrationBinding affinity towards human HRH1 in an in vitro assay measured by filtration	ChEMBL	344	5	1	5	2.7	CN1CCCN=C1COC(=O)C(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
		135398737	958	93	None	2	89	Human	9.4	pEC50	=	9.4	Binding	Inverse agonist activity at human histamine H1 receptor by R-SAT assayInverse agonist activity at human histamine H1 receptor by R-SAT assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		38	958	93	None	2	89	Human	9.4	pEC50	=	9.4	Binding	Inverse agonist activity at human histamine H1 receptor by R-SAT assayInverse agonist activity at human histamine H1 receptor by R-SAT assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		722	958	93	None	2	89	Human	9.4	pEC50	=	9.4	Binding	Inverse agonist activity at human histamine H1 receptor by R-SAT assayInverse agonist activity at human histamine H1 receptor by R-SAT assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		CHEMBL42	958	93	None	2	89	Human	9.4	pEC50	=	9.4	Binding	Inverse agonist activity at human histamine H1 receptor by R-SAT assayInverse agonist activity at human histamine H1 receptor by R-SAT assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		DB00363	958	93	None	2	89	Human	9.4	pEC50	=	9.4	Binding	Inverse agonist activity at human histamine H1 receptor by R-SAT assayInverse agonist activity at human histamine H1 receptor by R-SAT assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		11327353	165621	0	None	-	0	Guinea pig	6.9	pEC50	=	6.9	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	410	11	2	3	4.9	c1ccc(C(CCc2nc(CCNCCc3ccncc3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		CHEMBL424336	165621	0	None	-	0	Guinea pig	6.9	pEC50	=	6.9	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	410	11	2	3	4.9	c1ccc(C(CCc2nc(CCNCCc3ccncc3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		11201079	46218	0	None	-	0	Guinea pig	6.9	pEC50	=	6.9	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	424	12	2	3	5.3	c1ccc(C(CCc2nc(CCNCCCc3cccnc3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		CHEMBL153474	46218	0	None	-	0	Guinea pig	6.9	pEC50	=	6.9	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	424	12	2	3	5.3	c1ccc(C(CCc2nc(CCNCCCc3cccnc3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		11235688	119852	0	None	-	1	Guinea pig	6.9	pEC50	=	6.9	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	427	13	3	3	5.1	c1ccc(C(CCc2nc(CCNCCCCc3c[nH]cn3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		CHEMBL348656	119852	0	None	-	1	Guinea pig	6.9	pEC50	=	6.9	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	427	13	3	3	5.1	c1ccc(C(CCc2nc(CCNCCCCc3c[nH]cn3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		42625384	169773	0	None	-	1	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	209	4	3	2	-0.2	CC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/jm9000693
		CHEMBL443896	169773	0	None	-	1	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	209	4	3	2	-0.2	CC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/jm9000693
		1204	1932	119	None	-501	24	Human	7.9	pEC50	=	7.9	Binding	Inhibition of human Histamine H1 receptor using [3H]pyrilamineInhibition of human Histamine H1 receptor using [3H]pyrilamine	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm020415q
		1247	1932	119	None	-501	24	Human	7.9	pEC50	=	7.9	Binding	Inhibition of human Histamine H1 receptor using [3H]pyrilamineInhibition of human Histamine H1 receptor using [3H]pyrilamine	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm020415q
		1375	1932	119	None	-501	24	Human	7.9	pEC50	=	7.9	Binding	Inhibition of human Histamine H1 receptor using [3H]pyrilamineInhibition of human Histamine H1 receptor using [3H]pyrilamine	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm020415q
		774	1932	119	None	-501	24	Human	7.9	pEC50	=	7.9	Binding	Inhibition of human Histamine H1 receptor using [3H]pyrilamineInhibition of human Histamine H1 receptor using [3H]pyrilamine	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm020415q
		CHEMBL90	1932	119	None	-501	24	Human	7.9	pEC50	=	7.9	Binding	Inhibition of human Histamine H1 receptor using [3H]pyrilamineInhibition of human Histamine H1 receptor using [3H]pyrilamine	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm020415q
		DB05381	1932	119	None	-501	24	Human	7.9	pEC50	=	7.9	Binding	Inhibition of human Histamine H1 receptor using [3H]pyrilamineInhibition of human Histamine H1 receptor using [3H]pyrilamine	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm020415q
		11407994	46478	0	None	-	0	Guinea pig	7.9	pEC50	=	7.9	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	438	13	2	3	5.7	c1ccc(C(CCc2nc(CCNCCCCc3cccnc3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		CHEMBL153736	46478	0	None	-	0	Guinea pig	7.9	pEC50	=	7.9	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	438	13	2	3	5.7	c1ccc(C(CCc2nc(CCNCCCCc3cccnc3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		11269940	46531	1	None	-	1	Guinea pig	7.9	pEC50	=	7.9	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	413	12	3	3	4.7	c1ccc(C(CCc2nc(CCNCCCc3c[nH]cn3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		CHEMBL153776	46531	1	None	-	1	Guinea pig	7.9	pEC50	=	7.9	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	413	12	3	3	4.7	c1ccc(C(CCc2nc(CCNCCCc3c[nH]cn3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		10410901	119747	0	None	3	2	Guinea pig	7.9	pEC50	=	7.9	Binding	Effective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig AortaEffective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig Aorta	ChEMBL	438	13	2	3	5.7	c1ccc(C(CCc2nc(CCNCCCCc3ccccn3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		CHEMBL347796	119747	0	None	3	2	Guinea pig	7.9	pEC50	=	7.9	Binding	Effective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig AortaEffective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig Aorta	ChEMBL	438	13	2	3	5.7	c1ccc(C(CCc2nc(CCNCCCCc3ccccn3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		11166893	46214	0	None	-	0	Guinea pig	7.8	pEC50	=	7.8	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	452	14	2	3	6.1	c1ccc(C(CCc2nc(CCNCCCCCc3ccccn3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		CHEMBL153468	46214	0	None	-	0	Guinea pig	7.8	pEC50	=	7.8	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	452	14	2	3	6.1	c1ccc(C(CCc2nc(CCNCCCCCc3ccccn3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		10447834	1933	4	None	8	5	Guinea pig	6.8	pEC50	=	6.8	Binding	Effective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig AortaEffective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig Aorta	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm0309147
		4026	1933	4	None	8	5	Guinea pig	6.8	pEC50	=	6.8	Binding	Effective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig AortaEffective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig Aorta	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm0309147
		CHEMBL275507	1933	4	None	8	5	Guinea pig	6.8	pEC50	=	6.8	Binding	Effective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig AortaEffective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig Aorta	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm0309147
		10403687	2511	3	None	-7	5	Rat	6.8	pEC50	=	6.8	Binding	Effective concentration against histamine H1 receptor in rat aortaEffective concentration against histamine H1 receptor in rat aorta	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm0309147
		1205	2511	3	None	-7	5	Rat	6.8	pEC50	=	6.8	Binding	Effective concentration against histamine H1 receptor in rat aortaEffective concentration against histamine H1 receptor in rat aorta	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm0309147
		CHEMBL275035	2511	3	None	-7	5	Rat	6.8	pEC50	=	6.8	Binding	Effective concentration against histamine H1 receptor in rat aortaEffective concentration against histamine H1 receptor in rat aorta	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm0309147
		1204	1932	119	None	-46	24	Guinea pig	6.8	pEC50	=	6.8	Binding	Effective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig AortaEffective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig Aorta	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0309147
		1247	1932	119	None	-46	24	Guinea pig	6.8	pEC50	=	6.8	Binding	Effective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig AortaEffective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig Aorta	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0309147
		1375	1932	119	None	-46	24	Guinea pig	6.8	pEC50	=	6.8	Binding	Effective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig AortaEffective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig Aorta	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0309147
		774	1932	119	None	-46	24	Guinea pig	6.8	pEC50	=	6.8	Binding	Effective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig AortaEffective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig Aorta	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0309147
		CHEMBL90	1932	119	None	-46	24	Guinea pig	6.8	pEC50	=	6.8	Binding	Effective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig AortaEffective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig Aorta	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0309147
		DB05381	1932	119	None	-46	24	Guinea pig	6.8	pEC50	=	6.8	Binding	Effective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig AortaEffective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig Aorta	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0309147
		42626110	179769	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	310	5	4	2	1.6	N/C(=N\C(=O)c1cc2ccccc2[nH]1)NCCCc1c[nH]cn1	10.1021/jm9000693
		CHEMBL474448	179769	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	310	5	4	2	1.6	N/C(=N\C(=O)c1cc2ccccc2[nH]1)NCCCc1c[nH]cn1	10.1021/jm9000693
		10447834	1933	4	None	8	5	Guinea pig	6.7	pEC50	=	6.7	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm0309147
		4026	1933	4	None	8	5	Guinea pig	6.7	pEC50	=	6.7	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm0309147
		CHEMBL275507	1933	4	None	8	5	Guinea pig	6.7	pEC50	=	6.7	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm0309147
		1204	1932	119	None	-501	24	Human	6.7	pEC50	=	6.7	Binding	Activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayActivity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm800841w
		1247	1932	119	None	-501	24	Human	6.7	pEC50	=	6.7	Binding	Activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayActivity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm800841w
		1375	1932	119	None	-501	24	Human	6.7	pEC50	=	6.7	Binding	Activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayActivity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm800841w
		774	1932	119	None	-501	24	Human	6.7	pEC50	=	6.7	Binding	Activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayActivity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm800841w
		CHEMBL90	1932	119	None	-501	24	Human	6.7	pEC50	=	6.7	Binding	Activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayActivity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm800841w
		DB05381	1932	119	None	-501	24	Human	6.7	pEC50	=	6.7	Binding	Activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayActivity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm800841w
		1204	1932	119	None	-501	24	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 or RGS9 assessed as increase in 32Pi level incubated for 20 mins by liquid scintillation counting in presence of [gamma32P]GTPAgonist activity at human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 or RGS9 assessed as increase in 32Pi level incubated for 20 mins by liquid scintillation counting in presence of [gamma32P]GTP	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		1247	1932	119	None	-501	24	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 or RGS9 assessed as increase in 32Pi level incubated for 20 mins by liquid scintillation counting in presence of [gamma32P]GTPAgonist activity at human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 or RGS9 assessed as increase in 32Pi level incubated for 20 mins by liquid scintillation counting in presence of [gamma32P]GTP	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		1375	1932	119	None	-501	24	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 or RGS9 assessed as increase in 32Pi level incubated for 20 mins by liquid scintillation counting in presence of [gamma32P]GTPAgonist activity at human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 or RGS9 assessed as increase in 32Pi level incubated for 20 mins by liquid scintillation counting in presence of [gamma32P]GTP	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		774	1932	119	None	-501	24	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 or RGS9 assessed as increase in 32Pi level incubated for 20 mins by liquid scintillation counting in presence of [gamma32P]GTPAgonist activity at human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 or RGS9 assessed as increase in 32Pi level incubated for 20 mins by liquid scintillation counting in presence of [gamma32P]GTP	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		CHEMBL90	1932	119	None	-501	24	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 or RGS9 assessed as increase in 32Pi level incubated for 20 mins by liquid scintillation counting in presence of [gamma32P]GTPAgonist activity at human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 or RGS9 assessed as increase in 32Pi level incubated for 20 mins by liquid scintillation counting in presence of [gamma32P]GTP	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		DB05381	1932	119	None	-501	24	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 or RGS9 assessed as increase in 32Pi level incubated for 20 mins by liquid scintillation counting in presence of [gamma32P]GTPAgonist activity at human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 or RGS9 assessed as increase in 32Pi level incubated for 20 mins by liquid scintillation counting in presence of [gamma32P]GTP	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.6b00120
		1204	1932	119	None	-501	24	Human	6.7	pEC50	=	6.7	Binding	Activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayActivity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.03.082
		1247	1932	119	None	-501	24	Human	6.7	pEC50	=	6.7	Binding	Activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayActivity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.03.082
		1375	1932	119	None	-501	24	Human	6.7	pEC50	=	6.7	Binding	Activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayActivity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.03.082
		774	1932	119	None	-501	24	Human	6.7	pEC50	=	6.7	Binding	Activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayActivity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.03.082
		CHEMBL90	1932	119	None	-501	24	Human	6.7	pEC50	=	6.7	Binding	Activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayActivity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.03.082
		DB05381	1932	119	None	-501	24	Human	6.7	pEC50	=	6.7	Binding	Activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayActivity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.bmcl.2010.03.082
		1204	1932	119	None	-501	24	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm9000693
		1247	1932	119	None	-501	24	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm9000693
		1375	1932	119	None	-501	24	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm9000693
		774	1932	119	None	-501	24	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm9000693
		CHEMBL90	1932	119	None	-501	24	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm9000693
		DB05381	1932	119	None	-501	24	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm9000693
		1204	1932	119	None	-501	24	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assayAgonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C3MD00245D
		1247	1932	119	None	-501	24	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assayAgonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C3MD00245D
		1375	1932	119	None	-501	24	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assayAgonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C3MD00245D
		774	1932	119	None	-501	24	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assayAgonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C3MD00245D
		CHEMBL90	1932	119	None	-501	24	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assayAgonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C3MD00245D
		DB05381	1932	119	None	-501	24	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assayAgonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assay	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1039/C3MD00245D
		1204	1932	119	None	-46	24	Guinea pig	6.7	pEC50	=	6.7	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0309147
		1247	1932	119	None	-46	24	Guinea pig	6.7	pEC50	=	6.7	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0309147
		1375	1932	119	None	-46	24	Guinea pig	6.7	pEC50	=	6.7	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0309147
		774	1932	119	None	-46	24	Guinea pig	6.7	pEC50	=	6.7	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0309147
		CHEMBL90	1932	119	None	-46	24	Guinea pig	6.7	pEC50	=	6.7	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0309147
		DB05381	1932	119	None	-46	24	Guinea pig	6.7	pEC50	=	6.7	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0309147
		1227	2489	43	None	-2	12	Human	8.6	pEC50	=	8.6	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO-K1 cellsDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/np058114h
		2331	2489	43	None	-2	12	Human	8.6	pEC50	=	8.6	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO-K1 cellsDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/np058114h
		3957	2489	43	None	-2	12	Human	8.6	pEC50	=	8.6	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO-K1 cellsDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/np058114h
		4992	2489	43	None	-2	12	Human	8.6	pEC50	=	8.6	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO-K1 cellsDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/np058114h
		CHEMBL511	2489	43	None	-2	12	Human	8.6	pEC50	=	8.6	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO-K1 cellsDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/np058114h
		DB06691	2489	43	None	-2	12	Human	8.6	pEC50	=	8.6	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO-K1 cellsDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/np058114h
		10364258	45769	0	None	2	2	Guinea pig	7.7	pEC50	=	7.7	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	410	11	2	3	4.9	c1ccc(C(CCc2nc(CCNCCc3ccccn3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		CHEMBL153067	45769	0	None	2	2	Guinea pig	7.7	pEC50	=	7.7	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	410	11	2	3	4.9	c1ccc(C(CCc2nc(CCNCCc3ccccn3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		11475781	46057	0	None	-	0	Guinea pig	7.7	pEC50	=	7.7	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	424	12	2	3	5.3	c1ccc(C(CCc2nc(CCNCCCc3ccccn3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		CHEMBL153321	46057	0	None	-	0	Guinea pig	7.7	pEC50	=	7.7	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	424	12	2	3	5.3	c1ccc(C(CCc2nc(CCNCCCc3ccccn3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		42625386	178353	0	None	-	1	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	237	6	3	2	0.6	CCCC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/jm9000693
		CHEMBL465170	178353	0	None	-	1	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	237	6	3	2	0.6	CCCC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/jm9000693
		11453438	45701	0	None	-	0	Guinea pig	7.6	pEC50	=	7.6	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	438	13	2	3	5.7	c1ccc(C(CCc2nc(CCNCCCCc3ccncc3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		CHEMBL153010	45701	0	None	-	0	Guinea pig	7.6	pEC50	=	7.6	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	438	13	2	3	5.7	c1ccc(C(CCc2nc(CCNCCCCc3ccncc3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		10410901	119747	0	None	-3	2	Rat	6.6	pEC50	=	6.6	Binding	Effective concentration against histamine H1 receptor in rat aortaEffective concentration against histamine H1 receptor in rat aorta	ChEMBL	438	13	2	3	5.7	c1ccc(C(CCc2nc(CCNCCCCc3ccccn3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		CHEMBL347796	119747	0	None	-3	2	Rat	6.6	pEC50	=	6.6	Binding	Effective concentration against histamine H1 receptor in rat aortaEffective concentration against histamine H1 receptor in rat aorta	ChEMBL	438	13	2	3	5.7	c1ccc(C(CCc2nc(CCNCCCCc3ccccn3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		42625304	179100	0	None	-	1	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	237	5	3	2	0.4	CC(C)C(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/jm9000693
		CHEMBL471724	179100	0	None	-	1	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	237	5	3	2	0.4	CC(C)C(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/jm9000693
		11775345	42176	0	None	-	0	Guinea pig	7.6	pEC50	=	7.6	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	452	14	2	3	6.1	c1ccc(C(CCc2nc(CCNCCCCCc3cccnc3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		CHEMBL149684	42176	0	None	-	0	Guinea pig	7.6	pEC50	=	7.6	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	452	14	2	3	6.1	c1ccc(C(CCc2nc(CCNCCCCCc3cccnc3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		11339274	119624	0	None	-	0	Guinea pig	6.6	pEC50	=	6.6	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	424	12	2	3	5.3	c1ccc(C(CCc2nc(CCNCCCc3ccncc3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		CHEMBL346620	119624	0	None	-	0	Guinea pig	6.6	pEC50	=	6.6	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	424	12	2	3	5.3	c1ccc(C(CCc2nc(CCNCCCc3ccncc3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		11741669	96753	0	None	-2	2	Rat	6.5	pEC50	=	6.5	Binding	Effective concentration against histamine H1 receptor in rat aortaEffective concentration against histamine H1 receptor in rat aorta	ChEMBL	399	11	3	3	4.3	c1ccc(C(CCc2nc(CCNCCc3cnc[nH]3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		CHEMBL264491	96753	0	None	-2	2	Rat	6.5	pEC50	=	6.5	Binding	Effective concentration against histamine H1 receptor in rat aortaEffective concentration against histamine H1 receptor in rat aorta	ChEMBL	399	11	3	3	4.3	c1ccc(C(CCc2nc(CCNCCc3cnc[nH]3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		42625303	180766	0	None	-	1	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	223	5	3	2	0.2	CCC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/jm9000693
		CHEMBL475621	180766	0	None	-	1	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation countingAgonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation counting	ChEMBL	223	5	3	2	0.2	CCC(=O)/N=C(\N)NCCCc1c[nH]cn1	10.1021/jm9000693
		10403687	2511	3	None	7	5	Guinea pig	7.4	pEC50	=	7.4	Binding	Effective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig AortaEffective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig Aorta	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm0309147
		1205	2511	3	None	7	5	Guinea pig	7.4	pEC50	=	7.4	Binding	Effective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig AortaEffective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig Aorta	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm0309147
		CHEMBL275035	2511	3	None	7	5	Guinea pig	7.4	pEC50	=	7.4	Binding	Effective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig AortaEffective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig Aorta	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm0309147
		1204	1932	119	None	-309	24	Rat	5.4	pEC50	=	5.4	Binding	Effective concentration against histamine H1 receptor in rat aortaEffective concentration against histamine H1 receptor in rat aorta	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0309147
		1247	1932	119	None	-309	24	Rat	5.4	pEC50	=	5.4	Binding	Effective concentration against histamine H1 receptor in rat aortaEffective concentration against histamine H1 receptor in rat aorta	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0309147
		1375	1932	119	None	-309	24	Rat	5.4	pEC50	=	5.4	Binding	Effective concentration against histamine H1 receptor in rat aortaEffective concentration against histamine H1 receptor in rat aorta	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0309147
		774	1932	119	None	-309	24	Rat	5.4	pEC50	=	5.4	Binding	Effective concentration against histamine H1 receptor in rat aortaEffective concentration against histamine H1 receptor in rat aorta	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0309147
		CHEMBL90	1932	119	None	-309	24	Rat	5.4	pEC50	=	5.4	Binding	Effective concentration against histamine H1 receptor in rat aortaEffective concentration against histamine H1 receptor in rat aorta	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0309147
		DB05381	1932	119	None	-309	24	Rat	5.4	pEC50	=	5.4	Binding	Effective concentration against histamine H1 receptor in rat aortaEffective concentration against histamine H1 receptor in rat aorta	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm0309147
		11741669	96753	0	None	2	2	Guinea pig	8.3	pEC50	=	8.3	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	399	11	3	3	4.3	c1ccc(C(CCc2nc(CCNCCc3cnc[nH]3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		CHEMBL264491	96753	0	None	2	2	Guinea pig	8.3	pEC50	=	8.3	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	399	11	3	3	4.3	c1ccc(C(CCc2nc(CCNCCc3cnc[nH]3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		10364258	45769	0	None	-2	2	Rat	6.3	pEC50	=	6.3	Binding	Effective concentration against histamine H1 receptor in rat aortaEffective concentration against histamine H1 receptor in rat aorta	ChEMBL	410	11	2	3	4.9	c1ccc(C(CCc2nc(CCNCCc3ccccn3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		CHEMBL153067	45769	0	None	-2	2	Rat	6.3	pEC50	=	6.3	Binding	Effective concentration against histamine H1 receptor in rat aortaEffective concentration against histamine H1 receptor in rat aorta	ChEMBL	410	11	2	3	4.9	c1ccc(C(CCc2nc(CCNCCc3ccccn3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		10403687	2511	3	None	7	5	Guinea pig	7.2	pEC50	=	7.2	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm0309147
		1205	2511	3	None	7	5	Guinea pig	7.2	pEC50	=	7.2	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm0309147
		CHEMBL275035	2511	3	None	7	5	Guinea pig	7.2	pEC50	=	7.2	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm0309147
		10410901	119747	0	None	3	2	Guinea pig	8.2	pEC50	=	8.2	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	438	13	2	3	5.7	c1ccc(C(CCc2nc(CCNCCCCc3ccccn3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		CHEMBL347796	119747	0	None	3	2	Guinea pig	8.2	pEC50	=	8.2	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	438	13	2	3	5.7	c1ccc(C(CCc2nc(CCNCCCCc3ccccn3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		46887041	8760	1	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayActivity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay	ChEMBL	313	7	4	3	2.2	C[C@H](CC(=O)NC(=N)NCCCc1c[nH]cn1)c1ccccc1	10.1016/j.bmcl.2010.03.082
		CHEMBL1096428	8760	1	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayActivity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay	ChEMBL	313	7	4	3	2.2	C[C@H](CC(=O)NC(=N)NCCCc1c[nH]cn1)c1ccccc1	10.1016/j.bmcl.2010.03.082
		46887043	8763	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayActivity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay	ChEMBL	319	7	4	3	2.6	C[C@@H](CC(=O)NC(=N)NCCCc1c[nH]cn1)C1CCCCC1	10.1016/j.bmcl.2010.03.082
		CHEMBL1096431	8763	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayActivity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay	ChEMBL	319	7	4	3	2.6	C[C@@H](CC(=O)NC(=N)NCCCc1c[nH]cn1)C1CCCCC1	10.1016/j.bmcl.2010.03.082
		11269875	121004	0	None	-	1	Guinea pig	7.1	pEC50	=	7.1	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	410	11	2	3	4.9	c1ccc(C(CCc2nc(CCNCCc3cccnc3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		CHEMBL356449	121004	0	None	-	1	Guinea pig	7.1	pEC50	=	7.1	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	410	11	2	3	4.9	c1ccc(C(CCc2nc(CCNCCc3cccnc3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		10364258	45769	0	None	2	2	Guinea pig	7.1	pEC50	=	7.1	Binding	Effective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig AortaEffective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig Aorta	ChEMBL	410	11	2	3	4.9	c1ccc(C(CCc2nc(CCNCCc3ccccn3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		CHEMBL153067	45769	0	None	2	2	Guinea pig	7.1	pEC50	=	7.1	Binding	Effective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig AortaEffective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig Aorta	ChEMBL	410	11	2	3	4.9	c1ccc(C(CCc2nc(CCNCCc3ccccn3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		11269875	121004	0	None	-	1	Guinea pig	7.1	pEC50	=	7.1	Binding	Effective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig AortaEffective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig Aorta	ChEMBL	410	11	2	3	4.9	c1ccc(C(CCc2nc(CCNCCc3cccnc3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		CHEMBL356449	121004	0	None	-	1	Guinea pig	7.1	pEC50	=	7.1	Binding	Effective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig AortaEffective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig Aorta	ChEMBL	410	11	2	3	4.9	c1ccc(C(CCc2nc(CCNCCc3cccnc3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		46830167	8761	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayActivity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay	ChEMBL	313	7	4	3	2.2	C[C@@H](CC(=O)NC(=N)NCCCc1c[nH]cn1)c1ccccc1	10.1016/j.bmcl.2010.03.082
		CHEMBL1096429	8761	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayActivity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay	ChEMBL	313	7	4	3	2.2	C[C@@H](CC(=O)NC(=N)NCCCc1c[nH]cn1)c1ccccc1	10.1016/j.bmcl.2010.03.082
		10447834	1933	4	None	-8	5	Rat	6.1	pEC50	=	6.1	Binding	Effective concentration against histamine H1 receptor in rat aortaEffective concentration against histamine H1 receptor in rat aorta	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm0309147
		4026	1933	4	None	-8	5	Rat	6.1	pEC50	=	6.1	Binding	Effective concentration against histamine H1 receptor in rat aortaEffective concentration against histamine H1 receptor in rat aorta	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm0309147
		CHEMBL275507	1933	4	None	-8	5	Rat	6.1	pEC50	=	6.1	Binding	Effective concentration against histamine H1 receptor in rat aortaEffective concentration against histamine H1 receptor in rat aorta	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm0309147
		10374457	28895	2	None	-	2	Human	6.1	pEC50	=	6.1	Binding	Inhibition of human Histamine H1 receptor using [3H]pyrilamineInhibition of human Histamine H1 receptor using [3H]pyrilamine	ChEMBL	123	1	2	2	0.2	N[C@H]1C[C@@H]1c1c[nH]cn1	10.1021/jm020415q
		CHEMBL13795	28895	2	None	-	2	Human	6.1	pEC50	=	6.1	Binding	Inhibition of human Histamine H1 receptor using [3H]pyrilamineInhibition of human Histamine H1 receptor using [3H]pyrilamine	ChEMBL	123	1	2	2	0.2	N[C@H]1C[C@@H]1c1c[nH]cn1	10.1021/jm020415q
		46887042	8762	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayActivity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay	ChEMBL	319	7	4	3	2.6	C[C@H](CC(=O)NC(=N)NCCCc1c[nH]cn1)C1CCCCC1	10.1016/j.bmcl.2010.03.082
		CHEMBL1096430	8762	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayActivity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay	ChEMBL	319	7	4	3	2.6	C[C@H](CC(=O)NC(=N)NCCCc1c[nH]cn1)C1CCCCC1	10.1016/j.bmcl.2010.03.082
		11741669	96753	0	None	2	2	Guinea pig	8.0	pEC50	=	8.0	Binding	Effective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig AortaEffective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig Aorta	ChEMBL	399	11	3	3	4.3	c1ccc(C(CCc2nc(CCNCCc3cnc[nH]3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		CHEMBL264491	96753	0	None	2	2	Guinea pig	8.0	pEC50	=	8.0	Binding	Effective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig AortaEffective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig Aorta	ChEMBL	399	11	3	3	4.3	c1ccc(C(CCc2nc(CCNCCc3cnc[nH]3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		11178495	168668	0	None	-	0	Guinea pig	7.0	pEC50	=	7.0	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	452	14	2	3	6.1	c1ccc(C(CCc2nc(CCNCCCCCc3ccncc3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		CHEMBL436415	168668	0	None	-	0	Guinea pig	7.0	pEC50	=	7.0	Binding	Effective concentration against histamine H1 receptor in guinea pig ileumEffective concentration against histamine H1 receptor in guinea pig ileum	ChEMBL	452	14	2	3	6.1	c1ccc(C(CCc2nc(CCNCCCCCc3ccncc3)c[nH]2)c2ccccc2)cc1	10.1021/jm0309147
		1227	2489	43	None	-2	12	Human	10.9	pIC50	=	10.9	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in HEK293 cellsDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in HEK293 cells	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmc.2016.03.006
		2331	2489	43	None	-2	12	Human	10.9	pIC50	=	10.9	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in HEK293 cellsDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in HEK293 cells	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmc.2016.03.006
		3957	2489	43	None	-2	12	Human	10.9	pIC50	=	10.9	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in HEK293 cellsDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in HEK293 cells	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmc.2016.03.006
		4992	2489	43	None	-2	12	Human	10.9	pIC50	=	10.9	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in HEK293 cellsDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in HEK293 cells	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmc.2016.03.006
		CHEMBL511	2489	43	None	-2	12	Human	10.9	pIC50	=	10.9	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in HEK293 cellsDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in HEK293 cells	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmc.2016.03.006
		DB06691	2489	43	None	-2	12	Human	10.9	pIC50	=	10.9	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in HEK293 cellsDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in HEK293 cells	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmc.2016.03.006
		180	401	56	None	-11	40	Rat	10.7	pIC50	=	10.7	Binding	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1021/jm9910369
		200	401	56	None	-11	40	Rat	10.7	pIC50	=	10.7	Binding	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1021/jm9910369
		2160	401	56	None	-11	40	Rat	10.7	pIC50	=	10.7	Binding	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1021/jm9910369
		CHEMBL629	401	56	None	-11	40	Rat	10.7	pIC50	=	10.7	Binding	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1021/jm9910369
		DB00321	401	56	None	-11	40	Rat	10.7	pIC50	=	10.7	Binding	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1021/jm9910369
		1971	2866	38	None	-9	30	Rat	10.3	pIC50	=	10.3	Binding	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1021/jm9910369
		2404	2866	38	None	-9	30	Rat	10.3	pIC50	=	10.3	Binding	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1021/jm9910369
		4543	2866	38	None	-9	30	Rat	10.3	pIC50	=	10.3	Binding	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1021/jm9910369
		CHEMBL445	2866	38	None	-9	30	Rat	10.3	pIC50	=	10.3	Binding	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1021/jm9910369
		DB00540	2866	38	None	-9	30	Rat	10.3	pIC50	=	10.3	Binding	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1021/jm9910369
		1427	2013	54	None	-1	27	Rat	10.2	pIC50	=	10.2	Binding	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1021/jm9910369
		357	2013	54	None	-1	27	Rat	10.2	pIC50	=	10.2	Binding	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1021/jm9910369
		3696	2013	54	None	-1	27	Rat	10.2	pIC50	=	10.2	Binding	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1021/jm9910369
		CHEMBL11	2013	54	None	-1	27	Rat	10.2	pIC50	=	10.2	Binding	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1021/jm9910369
		DB00458	2013	54	None	-1	27	Rat	10.2	pIC50	=	10.2	Binding	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1021/jm9910369
		76316323	85629	0	None	-	0	Guinea pig	10.2	pIC50	=	10.2	Binding	Inhibition of H1 receptor in Cavia porcellus (guinea pig) ileum assessed as inhibition of histamine-induced contractionInhibition of H1 receptor in Cavia porcellus (guinea pig) ileum assessed as inhibition of histamine-induced contraction	ChEMBL	314	2	1	6	1.6	NC(=O)c1c(N2CCCC2)nc2sc3ccccc3n2c1=O	10.1007/s00044-012-0100-4
		CHEMBL2283398	85629	0	None	-	0	Guinea pig	10.2	pIC50	=	10.2	Binding	Inhibition of H1 receptor in Cavia porcellus (guinea pig) ileum assessed as inhibition of histamine-induced contractionInhibition of H1 receptor in Cavia porcellus (guinea pig) ileum assessed as inhibition of histamine-induced contraction	ChEMBL	314	2	1	6	1.6	NC(=O)c1c(N2CCCC2)nc2sc3ccccc3n2c1=O	10.1007/s00044-012-0100-4
		2398	954	62	None	-	29	Rat	9.7	pIC50	=	9.7	Binding	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1021/jm9910369
		2801	954	62	None	-	29	Rat	9.7	pIC50	=	9.7	Binding	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1021/jm9910369
		701	954	62	None	-	29	Rat	9.7	pIC50	=	9.7	Binding	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1021/jm9910369
		CHEMBL415	954	62	None	-	29	Rat	9.7	pIC50	=	9.7	Binding	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1021/jm9910369
		DB01242	954	62	None	-	29	Rat	9.7	pIC50	=	9.7	Binding	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1021/jm9910369
		13726621	95265	0	None	-	0	Guinea pig	9.6	pIC50	=	9.6	Binding	Inhibition of [3H]mepyramine binding to the histamine receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the histamine receptor in guinea pig cortex	ChEMBL	311	3	0	4	2.2	CN1C[C@@H](CCN2CCC2)Oc2ncc(Cl)cc2C1=S	10.1021/jm00108a012
		CHEMBL25626	95265	0	None	-	0	Guinea pig	9.6	pIC50	=	9.6	Binding	Inhibition of [3H]mepyramine binding to the histamine receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the histamine receptor in guinea pig cortex	ChEMBL	311	3	0	4	2.2	CN1C[C@@H](CCN2CCC2)Oc2ncc(Cl)cc2C1=S	10.1021/jm00108a012
		26987	949	33	None	16	21	Human	9.4	pIC50	=	9.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		6063	949	33	None	16	21	Human	9.4	pIC50	=	9.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		671	949	33	None	16	21	Human	9.4	pIC50	=	9.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		CHEMBL1626	949	33	None	16	21	Human	9.4	pIC50	=	9.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		DB00283	949	33	None	16	21	Human	9.4	pIC50	=	9.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		3158	56267	27	None	40	20	Human	9.2	pIC50	=	9.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
		CHEMBL1628227	56267	27	None	40	20	Human	9.2	pIC50	=	9.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
		2995	204405	53	None	-42	23	Rat	9.1	pIC50	=	9.1	Binding	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1021/jm9910369
		CHEMBL1696	204405	53	None	-42	23	Rat	9.1	pIC50	=	9.1	Binding	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1021/jm9910369
		CHEMBL72	204405	53	None	-42	23	Rat	9.1	pIC50	=	9.1	Binding	Compound tested for its inhibitory activity against Histamine H1 receptorCompound tested for its inhibitory activity against Histamine H1 receptor	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1021/jm9910369
		1227	2489	43	None	-2	12	Human	9.1	pIC50	=	9.1	Binding	Binding affinity to human histamine H1 receptor by radioligand displacement assayBinding affinity to human histamine H1 receptor by radioligand displacement assay	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmc.2013.03.016
		2331	2489	43	None	-2	12	Human	9.1	pIC50	=	9.1	Binding	Binding affinity to human histamine H1 receptor by radioligand displacement assayBinding affinity to human histamine H1 receptor by radioligand displacement assay	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmc.2013.03.016
		3957	2489	43	None	-2	12	Human	9.1	pIC50	=	9.1	Binding	Binding affinity to human histamine H1 receptor by radioligand displacement assayBinding affinity to human histamine H1 receptor by radioligand displacement assay	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmc.2013.03.016
		4992	2489	43	None	-2	12	Human	9.1	pIC50	=	9.1	Binding	Binding affinity to human histamine H1 receptor by radioligand displacement assayBinding affinity to human histamine H1 receptor by radioligand displacement assay	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmc.2013.03.016
		CHEMBL511	2489	43	None	-2	12	Human	9.1	pIC50	=	9.1	Binding	Binding affinity to human histamine H1 receptor by radioligand displacement assayBinding affinity to human histamine H1 receptor by radioligand displacement assay	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmc.2013.03.016
		DB06691	2489	43	None	-2	12	Human	9.1	pIC50	=	9.1	Binding	Binding affinity to human histamine H1 receptor by radioligand displacement assayBinding affinity to human histamine H1 receptor by radioligand displacement assay	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmc.2013.03.016
		1224	1432	83	None	1	13	Guinea pig	9.0	pIC50	=	9	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1021/jm00173a011
		3100	1432	83	None	1	13	Guinea pig	9.0	pIC50	=	9	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1021/jm00173a011
		8980	1432	83	None	1	13	Guinea pig	9.0	pIC50	=	9	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1021/jm00173a011
		916	1432	83	None	1	13	Guinea pig	9.0	pIC50	=	9	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1021/jm00173a011
		CHEMBL657	1432	83	None	1	13	Guinea pig	9.0	pIC50	=	9	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1021/jm00173a011
		DB01075	1432	83	None	1	13	Guinea pig	9.0	pIC50	=	9	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1021/jm00173a011
		1530	2182	50	None	-5	21	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1016/j.bmc.2011.03.003
		3827	2182	50	None	-5	21	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1016/j.bmc.2011.03.003
		7206	2182	50	None	-5	21	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1016/j.bmc.2011.03.003
		CHEMBL534	2182	50	None	-5	21	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1016/j.bmc.2011.03.003
		DB00920	2182	50	None	-5	21	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1016/j.bmc.2011.03.003
		1530	2182	50	None	-5	21	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1016/j.bmcl.2009.03.124
		3827	2182	50	None	-5	21	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1016/j.bmcl.2009.03.124
		7206	2182	50	None	-5	21	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1016/j.bmcl.2009.03.124
		CHEMBL534	2182	50	None	-5	21	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1016/j.bmcl.2009.03.124
		DB00920	2182	50	None	-5	21	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1016/j.bmcl.2009.03.124
		2600	3779	74	None	1	13	Human	9.0	pIC50	=	9	Binding	Inhibition of histamine H1 receptor (unknown origin)Inhibition of histamine H1 receptor (unknown origin)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1021/jm501535r
		2608	3779	74	None	1	13	Human	9.0	pIC50	=	9	Binding	Inhibition of histamine H1 receptor (unknown origin)Inhibition of histamine H1 receptor (unknown origin)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1021/jm501535r
		5405	3779	74	None	1	13	Human	9.0	pIC50	=	9	Binding	Inhibition of histamine H1 receptor (unknown origin)Inhibition of histamine H1 receptor (unknown origin)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1021/jm501535r
		CHEMBL17157	3779	74	None	1	13	Human	9.0	pIC50	=	9	Binding	Inhibition of histamine H1 receptor (unknown origin)Inhibition of histamine H1 receptor (unknown origin)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1021/jm501535r
		DB00342	3779	74	None	1	13	Human	9.0	pIC50	=	9	Binding	Inhibition of histamine H1 receptor (unknown origin)Inhibition of histamine H1 receptor (unknown origin)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1021/jm501535r
		137125256	123051	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Inhibition of recombinant human histamine H1 receptorInhibition of recombinant human histamine H1 receptor	ChEMBL	328	0	1	4	3.3	CN1CCN(C2=Nc3cc(F)ccc3Nc3ccc(F)cc32)CC1	10.1021/acsmedchemlett.5b00102
		CHEMBL3609328	123051	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Inhibition of recombinant human histamine H1 receptorInhibition of recombinant human histamine H1 receptor	ChEMBL	328	0	1	4	3.3	CN1CCN(C2=Nc3cc(F)ccc3Nc3ccc(F)cc32)CC1	10.1021/acsmedchemlett.5b00102
		11976	920	59	None	-	24	Rat	9.0	pIC50	=	9.0	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1021/jm300671m
		667467	920	59	None	-	24	Rat	9.0	pIC50	=	9.0	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1021/jm300671m
		CHEMBL908	920	59	None	-	24	Rat	9.0	pIC50	=	9.0	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1021/jm300671m
		DB01239	920	59	None	-	24	Rat	9.0	pIC50	=	9.0	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1021/jm300671m
		1530	2182	50	None	-5	21	Human	8.9	pIC50	=	8.9	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		3827	2182	50	None	-5	21	Human	8.9	pIC50	=	8.9	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		7206	2182	50	None	-5	21	Human	8.9	pIC50	=	8.9	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		CHEMBL534	2182	50	None	-5	21	Human	8.9	pIC50	=	8.9	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		DB00920	2182	50	None	-5	21	Human	8.9	pIC50	=	8.9	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		44318581	205916	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.	ChEMBL	312	2	0	3	3.5	CN(C)CC1CC2c3ccccc3Cc3cc(F)ccc3N2O1	10.1016/s0960-894x(01)00721-1
		CHEMBL84081	205916	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.	ChEMBL	312	2	0	3	3.5	CN(C)CC1CC2c3ccccc3Cc3cc(F)ccc3N2O1	10.1016/s0960-894x(01)00721-1
		1227	2489	43	None	-2	12	Human	8.9	pIC50	=	8.9	Binding	Percent inhibition against Histamine H1 receptor at 1 uMPercent inhibition against Histamine H1 receptor at 1 uM	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm058018d
		2331	2489	43	None	-2	12	Human	8.9	pIC50	=	8.9	Binding	Percent inhibition against Histamine H1 receptor at 1 uMPercent inhibition against Histamine H1 receptor at 1 uM	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm058018d
		3957	2489	43	None	-2	12	Human	8.9	pIC50	=	8.9	Binding	Percent inhibition against Histamine H1 receptor at 1 uMPercent inhibition against Histamine H1 receptor at 1 uM	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm058018d
		4992	2489	43	None	-2	12	Human	8.9	pIC50	=	8.9	Binding	Percent inhibition against Histamine H1 receptor at 1 uMPercent inhibition against Histamine H1 receptor at 1 uM	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm058018d
		CHEMBL511	2489	43	None	-2	12	Human	8.9	pIC50	=	8.9	Binding	Percent inhibition against Histamine H1 receptor at 1 uMPercent inhibition against Histamine H1 receptor at 1 uM	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm058018d
		DB06691	2489	43	None	-2	12	Human	8.9	pIC50	=	8.9	Binding	Percent inhibition against Histamine H1 receptor at 1 uMPercent inhibition against Histamine H1 receptor at 1 uM	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm058018d
		1227	2489	43	None	-2	12	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]pyrilamine from human recombinant H1 receptor expressed in HEK293 cells measured after 60 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human recombinant H1 receptor expressed in HEK293 cells measured after 60 mins by scintillation counting method	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmc.2016.11.014
		2331	2489	43	None	-2	12	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]pyrilamine from human recombinant H1 receptor expressed in HEK293 cells measured after 60 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human recombinant H1 receptor expressed in HEK293 cells measured after 60 mins by scintillation counting method	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmc.2016.11.014
		3957	2489	43	None	-2	12	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]pyrilamine from human recombinant H1 receptor expressed in HEK293 cells measured after 60 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human recombinant H1 receptor expressed in HEK293 cells measured after 60 mins by scintillation counting method	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmc.2016.11.014
		4992	2489	43	None	-2	12	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]pyrilamine from human recombinant H1 receptor expressed in HEK293 cells measured after 60 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human recombinant H1 receptor expressed in HEK293 cells measured after 60 mins by scintillation counting method	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmc.2016.11.014
		CHEMBL511	2489	43	None	-2	12	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]pyrilamine from human recombinant H1 receptor expressed in HEK293 cells measured after 60 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human recombinant H1 receptor expressed in HEK293 cells measured after 60 mins by scintillation counting method	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmc.2016.11.014
		DB06691	2489	43	None	-2	12	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]pyrilamine from human recombinant H1 receptor expressed in HEK293 cells measured after 60 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human recombinant H1 receptor expressed in HEK293 cells measured after 60 mins by scintillation counting method	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmc.2016.11.014
		1227	2489	43	None	-2	12	Human	8.8	pIC50	=	8.8	Binding	Binding affinity to human histamine H1 receptor by radioligand displacement assayBinding affinity to human histamine H1 receptor by radioligand displacement assay	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.ejmech.2013.01.044
		2331	2489	43	None	-2	12	Human	8.8	pIC50	=	8.8	Binding	Binding affinity to human histamine H1 receptor by radioligand displacement assayBinding affinity to human histamine H1 receptor by radioligand displacement assay	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.ejmech.2013.01.044
		3957	2489	43	None	-2	12	Human	8.8	pIC50	=	8.8	Binding	Binding affinity to human histamine H1 receptor by radioligand displacement assayBinding affinity to human histamine H1 receptor by radioligand displacement assay	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.ejmech.2013.01.044
		4992	2489	43	None	-2	12	Human	8.8	pIC50	=	8.8	Binding	Binding affinity to human histamine H1 receptor by radioligand displacement assayBinding affinity to human histamine H1 receptor by radioligand displacement assay	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.ejmech.2013.01.044
		CHEMBL511	2489	43	None	-2	12	Human	8.8	pIC50	=	8.8	Binding	Binding affinity to human histamine H1 receptor by radioligand displacement assayBinding affinity to human histamine H1 receptor by radioligand displacement assay	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.ejmech.2013.01.044
		DB06691	2489	43	None	-2	12	Human	8.8	pIC50	=	8.8	Binding	Binding affinity to human histamine H1 receptor by radioligand displacement assayBinding affinity to human histamine H1 receptor by radioligand displacement assay	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.ejmech.2013.01.044
		1227	2489	43	None	2	12	Guinea pig	8.8	pIC50	=	8.8	Binding	Inhibition of guinea pig histamine H1 receptorInhibition of guinea pig histamine H1 receptor	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmc.2010.07.034
		2331	2489	43	None	2	12	Guinea pig	8.8	pIC50	=	8.8	Binding	Inhibition of guinea pig histamine H1 receptorInhibition of guinea pig histamine H1 receptor	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmc.2010.07.034
		3957	2489	43	None	2	12	Guinea pig	8.8	pIC50	=	8.8	Binding	Inhibition of guinea pig histamine H1 receptorInhibition of guinea pig histamine H1 receptor	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmc.2010.07.034
		4992	2489	43	None	2	12	Guinea pig	8.8	pIC50	=	8.8	Binding	Inhibition of guinea pig histamine H1 receptorInhibition of guinea pig histamine H1 receptor	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmc.2010.07.034
		CHEMBL511	2489	43	None	2	12	Guinea pig	8.8	pIC50	=	8.8	Binding	Inhibition of guinea pig histamine H1 receptorInhibition of guinea pig histamine H1 receptor	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmc.2010.07.034
		DB06691	2489	43	None	2	12	Guinea pig	8.8	pIC50	=	8.8	Binding	Inhibition of guinea pig histamine H1 receptorInhibition of guinea pig histamine H1 receptor	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmc.2010.07.034
		135	2532	43	None	-1	58	Human	8.8	pIC50	=	8.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		1796	2532	43	None	-1	58	Human	8.8	pIC50	=	8.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		4184	2532	43	None	-1	58	Human	8.8	pIC50	=	8.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		CHEMBL6437	2532	43	None	-1	58	Human	8.8	pIC50	=	8.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		DB06148	2532	43	None	-1	58	Human	8.8	pIC50	=	8.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		1027	1576	73	None	6	2	Guinea pig	8.8	pIC50	=	8.8	Binding	Potency against histamine H1 receptor on guinea pig ileumPotency against histamine H1 receptor on guinea pig ileum	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1021/jm00017a019
		3241	1576	73	None	6	2	Guinea pig	8.8	pIC50	=	8.8	Binding	Potency against histamine H1 receptor on guinea pig ileumPotency against histamine H1 receptor on guinea pig ileum	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1021/jm00017a019
		7176	1576	73	None	6	2	Guinea pig	8.8	pIC50	=	8.8	Binding	Potency against histamine H1 receptor on guinea pig ileumPotency against histamine H1 receptor on guinea pig ileum	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1021/jm00017a019
		CHEMBL1106	1576	73	None	6	2	Guinea pig	8.8	pIC50	=	8.8	Binding	Potency against histamine H1 receptor on guinea pig ileumPotency against histamine H1 receptor on guinea pig ileum	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1021/jm00017a019
		DB00751	1576	73	None	6	2	Guinea pig	8.8	pIC50	=	8.8	Binding	Potency against histamine H1 receptor on guinea pig ileumPotency against histamine H1 receptor on guinea pig ileum	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1021/jm00017a019
		44461456	205749	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Binding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligandBinding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligand	ChEMBL	308	2	0	3	3.8	CN(C)CC1(C)CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
		CHEMBL82714	205749	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Binding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligandBinding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligand	ChEMBL	308	2	0	3	3.8	CN(C)CC1(C)CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
		72548703	161567	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor after 60 mins by scintillation counting analysisDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor after 60 mins by scintillation counting analysis	ChEMBL	583	8	3	6	5.8	CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12	10.1016/j.bmcl.2018.03.093
		CHEMBL4128926	161567	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor after 60 mins by scintillation counting analysisDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor after 60 mins by scintillation counting analysis	ChEMBL	583	8	3	6	5.8	CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12	10.1016/j.bmcl.2018.03.093
		44318554	107079	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.	ChEMBL	312	2	0	3	3.5	CN(C)CC1CC2c3ccccc3Cc3c(F)cccc3N2O1	10.1016/s0960-894x(01)00721-1
		CHEMBL315834	107079	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.	ChEMBL	312	2	0	3	3.5	CN(C)CC1CC2c3ccccc3Cc3c(F)cccc3N2O1	10.1016/s0960-894x(01)00721-1
		1227	2489	43	None	-2	12	Human	8.7	pIC50	=	8.7	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm701575k
		2331	2489	43	None	-2	12	Human	8.7	pIC50	=	8.7	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm701575k
		3957	2489	43	None	-2	12	Human	8.7	pIC50	=	8.7	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm701575k
		4992	2489	43	None	-2	12	Human	8.7	pIC50	=	8.7	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm701575k
		CHEMBL511	2489	43	None	-2	12	Human	8.7	pIC50	=	8.7	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm701575k
		DB06691	2489	43	None	-2	12	Human	8.7	pIC50	=	8.7	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm701575k
		124087	1389	114	None	3	15	Human	8.7	pIC50	=	8.7	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1016/j.bmcl.2019.126712
		7157	1389	114	None	3	15	Human	8.7	pIC50	=	8.7	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1016/j.bmcl.2019.126712
		814	1389	114	None	3	15	Human	8.7	pIC50	=	8.7	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1016/j.bmcl.2019.126712
		CHEMBL1172	1389	114	None	3	15	Human	8.7	pIC50	=	8.7	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1016/j.bmcl.2019.126712
		DB00967	1389	114	None	3	15	Human	8.7	pIC50	=	8.7	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1016/j.bmcl.2019.126712
		1227	2489	43	None	-2	12	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor in HEK293 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor in HEK293 cells after 60 mins by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/acs.jmedchem.6b01422
		2331	2489	43	None	-2	12	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor in HEK293 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor in HEK293 cells after 60 mins by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/acs.jmedchem.6b01422
		3957	2489	43	None	-2	12	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor in HEK293 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor in HEK293 cells after 60 mins by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/acs.jmedchem.6b01422
		4992	2489	43	None	-2	12	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor in HEK293 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor in HEK293 cells after 60 mins by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/acs.jmedchem.6b01422
		CHEMBL511	2489	43	None	-2	12	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor in HEK293 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor in HEK293 cells after 60 mins by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/acs.jmedchem.6b01422
		DB06691	2489	43	None	-2	12	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor in HEK293 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor in HEK293 cells after 60 mins by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/acs.jmedchem.6b01422
		13726596	93948	0	None	-	0	Guinea pig	8.7	pIC50	=	8.7	Binding	Inhibition of [3H]mepyramine binding to the histamine receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the histamine receptor in guinea pig cortex	ChEMBL	299	3	0	4	2.1	CN(C)CC[C@@H]1CN(C)C(=S)c2cc(Cl)cnc2O1	10.1021/jm00108a012
		CHEMBL24835	93948	0	None	-	0	Guinea pig	8.7	pIC50	=	8.7	Binding	Inhibition of [3H]mepyramine binding to the histamine receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the histamine receptor in guinea pig cortex	ChEMBL	299	3	0	4	2.1	CN(C)CC[C@@H]1CN(C)C(=S)c2cc(Cl)cnc2O1	10.1021/jm00108a012
		19426635	205593	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligandBinding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligand	ChEMBL	280	2	1	3	3.1	CNCC1CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
		CHEMBL81485	205593	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligandBinding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligand	ChEMBL	280	2	1	3	3.1	CNCC1CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
		9869791	63926	20	None	-	1	Rat	7.0	pIC50	=	7	Binding	Concentration for 50% inhibition towards central histamine H1 receptor Concentration for 50% inhibition towards central histamine H1 receptor	ChEMBL	480	8	1	7	0.9	CN1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1	10.1016/j.bmcl.2005.01.039
		CHEMBL180632	63926	20	None	-	1	Rat	7.0	pIC50	=	7	Binding	Concentration for 50% inhibition towards central histamine H1 receptor Concentration for 50% inhibition towards central histamine H1 receptor	ChEMBL	480	8	1	7	0.9	CN1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1	10.1016/j.bmcl.2005.01.039
		11453538	84744	0	None	-	0	Guinea pig	7.0	pIC50	=	7	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	442	10	1	6	4.7	CCOCCn1cc(C2CCN(CCOc3ccsc3C(=O)O)CC2)c2ccccc21	10.1021/jm0498203
		CHEMBL222927	84744	0	None	-	0	Guinea pig	7.0	pIC50	=	7	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	442	10	1	6	4.7	CCOCCn1cc(C2CCN(CCOc3ccsc3C(=O)O)CC2)c2ccccc21	10.1021/jm0498203
		11396873	136985	0	None	-	0	Guinea pig	7.0	pIC50	=	7	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	454	10	1	5	4.8	CCOCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2cc(F)ccc21	10.1021/jm0498203
		CHEMBL374585	136985	0	None	-	0	Guinea pig	7.0	pIC50	=	7	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	454	10	1	5	4.8	CCOCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2cc(F)ccc21	10.1021/jm0498203
		1853	3551	38	None	-	1	Human	7.0	pIC50	=	7	Binding	Inhibitory concentration against histamine H1 receptorInhibitory concentration against histamine H1 receptor	ChEMBL	352	0	0	2	4.3	Clc1ccc2c(c1)CCc1c(C2=C2CCN(CC2)C(=O)C)nccc1	10.1021/jm058225d
		60680	3551	38	None	-	1	Human	7.0	pIC50	=	7	Binding	Inhibitory concentration against histamine H1 receptorInhibitory concentration against histamine H1 receptor	ChEMBL	352	0	0	2	4.3	Clc1ccc2c(c1)CCc1c(C2=C2CCN(CC2)C(=O)C)nccc1	10.1021/jm058225d
		CHEMBL10971	3551	38	None	-	1	Human	7.0	pIC50	=	7	Binding	Inhibitory concentration against histamine H1 receptorInhibitory concentration against histamine H1 receptor	ChEMBL	352	0	0	2	4.3	Clc1ccc2c(c1)CCc1c(C2=C2CCN(CC2)C(=O)C)nccc1	10.1021/jm058225d
		1613	2348	53	None	-	44	Rat	6.0	pIC50	=	6	Binding	Binding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligandBinding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligand	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm991005d
		205	2348	53	None	-	44	Rat	6.0	pIC50	=	6	Binding	Binding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligandBinding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligand	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm991005d
		3964	2348	53	None	-	44	Rat	6.0	pIC50	=	6	Binding	Binding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligandBinding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligand	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm991005d
		CHEMBL831	2348	53	None	-	44	Rat	6.0	pIC50	=	6	Binding	Binding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligandBinding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligand	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm991005d
		DB00408	2348	53	None	-	44	Rat	6.0	pIC50	=	6	Binding	Binding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligandBinding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligand	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm991005d
		3689	102771	55	None	-	0	Human	6.0	pIC50	=	6	Binding	Compound was tested for the binding affinity against histamine H1 receptor by using [3H]mepyramine as radioligandCompound was tested for the binding affinity against histamine H1 receptor by using [3H]mepyramine as radioligand	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/jm00114a018
		CHEMBL1372983	102771	55	None	-	0	Human	6.0	pIC50	=	6	Binding	Compound was tested for the binding affinity against histamine H1 receptor by using [3H]mepyramine as radioligandCompound was tested for the binding affinity against histamine H1 receptor by using [3H]mepyramine as radioligand	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/jm00114a018
		CHEMBL305187	102771	55	None	-	0	Human	6.0	pIC50	=	6	Binding	Compound was tested for the binding affinity against histamine H1 receptor by using [3H]mepyramine as radioligandCompound was tested for the binding affinity against histamine H1 receptor by using [3H]mepyramine as radioligand	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/jm00114a018
		11430418	18786	12	None	-	1	Human	6.0	pIC50	=	6	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptorDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor	ChEMBL	432	6	1	7	2.5	Nn1c(CCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2c(c1=O)CCCC2	10.1021/jm1002292
		CHEMBL1278088	18786	12	None	-	1	Human	6.0	pIC50	=	6	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptorDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor	ChEMBL	432	6	1	7	2.5	Nn1c(CCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2c(c1=O)CCCC2	10.1021/jm1002292
		11459394	48166	1	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	251	12	2	2	3.8	NCCCCCCCCCCCCc1c[nH]cn1	10.1021/jm030936t
		CHEMBL155188	48166	1	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	251	12	2	2	3.8	NCCCCCCCCCCCCc1c[nH]cn1	10.1021/jm030936t
		5310982	93612	4	None	-	3	Human	6.0	pIC50	=	6	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	255	3	2	2	2.6	NCCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1	10.1021/jm030936t
		CHEMBL24665	93612	4	None	-	3	Human	6.0	pIC50	=	6	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	255	3	2	2	2.6	NCCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1	10.1021/jm030936t
		107782	14468	18	None	1	5	Human	5.0	pIC50	=	5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	472	4	4	6	2.0	C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)(O)O	nan
		67151996	14468	18	None	1	5	Human	5.0	pIC50	=	5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	472	4	4	6	2.0	C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)(O)O	nan
		CHEMBL1201207	14468	18	None	1	5	Human	5.0	pIC50	=	5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	472	4	4	6	2.0	C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)(O)O	nan
		44461357	104374	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Binding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligandBinding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligand	ChEMBL	330	2	0	4	4.3	CN(C)CC1CC2c3ccccc3Oc3ccc(Cl)cc3N2O1	10.1016/s0960-894x(01)00721-1
		CHEMBL310183	104374	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Binding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligandBinding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligand	ChEMBL	330	2	0	4	4.3	CN(C)CC1CC2c3ccccc3Oc3ccc(Cl)cc3N2O1	10.1016/s0960-894x(01)00721-1
		10205121	66692	0	None	-	0	Guinea pig	7.0	pIC50	=	7.0	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	464	6	1	4	6.5	O=C(O)c1cccc(CN2CCC(c3cn(Cc4ccc(Cl)s4)c4ccccc34)CC2)c1	10.1021/jm0498203
		CHEMBL185489	66692	0	None	-	0	Guinea pig	7.0	pIC50	=	7.0	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	464	6	1	4	6.5	O=C(O)c1cccc(CN2CCC(c3cn(Cc4ccc(Cl)s4)c4ccccc34)CC2)c1	10.1021/jm0498203
		45268185	196107	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	535	8	1	9	2.9	Cn1c(N2CCN(CCCN3c4ccccc4Sc4ccc(CCC(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmcl.2009.03.124
		CHEMBL560917	196107	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	535	8	1	9	2.9	Cn1c(N2CCN(CCCN3c4ccccc4Sc4ccc(CCC(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmcl.2009.03.124
		14762577	4468	0	None	-	0	Guinea pig	6.0	pIC50	=	6.0	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	336	6	1	2	3.7	Cc1ccccc1C(=O)NCCN1CCC(Cc2ccccc2)CC1	10.1021/jm00173a011
		CHEMBL101790	4468	0	None	-	0	Guinea pig	6.0	pIC50	=	6.0	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	336	6	1	2	3.7	Cc1ccccc1C(=O)NCCN1CCC(Cc2ccccc2)CC1	10.1021/jm00173a011
		44318841	106927	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.	ChEMBL	308	2	0	3	3.7	Cc1cccc2c1C1CC(CN(C)C)ON1c1ccccc1C2	10.1016/s0960-894x(01)00721-1
		CHEMBL314795	106927	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.	ChEMBL	308	2	0	3	3.7	Cc1cccc2c1C1CC(CN(C)C)ON1c1ccccc1C2	10.1016/s0960-894x(01)00721-1
		155554175	175693	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	490	6	1	5	5.2	COc1ccc(OCC(O)CN2CCC(=C3c4ccc(Cl)cc4CCc4cccnc43)CC2)cc1	10.1016/j.bmcl.2019.126712
		CHEMBL4581995	175693	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	490	6	1	5	5.2	COc1ccc(OCC(O)CN2CCC(=C3c4ccc(Cl)cc4CCc4cccnc43)CC2)cc1	10.1016/j.bmcl.2019.126712
		9904236	14076	22	None	-	1	Human	5.0	pIC50	=	5.0	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.	ChEMBL	295	0	1	3	3.7	O=C1Cc2ccccc2C(=C2CCNCC2)c2ccsc21	nan
		CHEMBL1197564	14076	22	None	-	1	Human	5.0	pIC50	=	5.0	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.	ChEMBL	295	0	1	3	3.7	O=C1Cc2ccccc2C(=C2CCNCC2)c2ccsc21	nan
		9904236	14076	22	None	-	1	Human	5.0	pIC50	=	5.0	Binding	Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	295	0	1	3	3.7	O=C1Cc2ccccc2C(=C2CCNCC2)c2ccsc21	nan
		CHEMBL1197564	14076	22	None	-	1	Human	5.0	pIC50	=	5.0	Binding	Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	295	0	1	3	3.7	O=C1Cc2ccccc2C(=C2CCNCC2)c2ccsc21	nan
		118162109	186246	11	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of histamine H1 receptor (unknown origin)Inhibition of histamine H1 receptor (unknown origin)	ChEMBL	447	8	3	9	3.1	CC(F)(F)COc1ncncc1CNc1ncc(C#N)c(N[C@@H]2CC[C@H](O)C(C)(C)C2)n1	10.1021/acs.jmedchem.1c00388
		CHEMBL4873647	186246	11	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of histamine H1 receptor (unknown origin)Inhibition of histamine H1 receptor (unknown origin)	ChEMBL	447	8	3	9	3.1	CC(F)(F)COc1ncncc1CNc1ncc(C#N)c(N[C@@H]2CC[C@H](O)C(C)(C)C2)n1	10.1021/acs.jmedchem.1c00388
		736282	78142	12	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	ChEMBL	337	6	1	3	4.2	CN1[C@H](CC(=O)c2ccccc2)CCC[C@@H]1C[C@H](O)c1ccccc1	10.1021/jm300671m
		CHEMBL2103769	78142	12	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	ChEMBL	337	6	1	3	4.2	CN1[C@H](CC(=O)c2ccccc2)CCC[C@@H]1C[C@H](O)c1ccccc1	10.1021/jm300671m
		13726595	99573	0	None	-	0	Guinea pig	4.9	pIC50	=	4.9	Binding	Inhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortex	ChEMBL	299	3	0	4	2.1	CN(C)CC[C@H]1CN(C)C(=S)c2cc(Cl)cnc2O1	10.1021/jm00108a012
		CHEMBL283760	99573	0	None	-	0	Guinea pig	4.9	pIC50	=	4.9	Binding	Inhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortex	ChEMBL	299	3	0	4	2.1	CN(C)CC[C@H]1CN(C)C(=S)c2cc(Cl)cnc2O1	10.1021/jm00108a012
		2726	919	68	None	-2	72	Human	7.9	pIC50	=	7.9	Binding	Binding affinity to histamine H1 receptor (unknown origin) by radioligand binding assayBinding affinity to histamine H1 receptor (unknown origin) by radioligand binding assay	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm400856t
		621	919	68	None	-2	72	Human	7.9	pIC50	=	7.9	Binding	Binding affinity to histamine H1 receptor (unknown origin) by radioligand binding assayBinding affinity to histamine H1 receptor (unknown origin) by radioligand binding assay	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm400856t
		83	919	68	None	-2	72	Human	7.9	pIC50	=	7.9	Binding	Binding affinity to histamine H1 receptor (unknown origin) by radioligand binding assayBinding affinity to histamine H1 receptor (unknown origin) by radioligand binding assay	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm400856t
		CHEMBL71	919	68	None	-2	72	Human	7.9	pIC50	=	7.9	Binding	Binding affinity to histamine H1 receptor (unknown origin) by radioligand binding assayBinding affinity to histamine H1 receptor (unknown origin) by radioligand binding assay	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm400856t
		DB00477	919	68	None	-2	72	Human	7.9	pIC50	=	7.9	Binding	Binding affinity to histamine H1 receptor (unknown origin) by radioligand binding assayBinding affinity to histamine H1 receptor (unknown origin) by radioligand binding assay	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm400856t
		1227	2489	43	None	-2	12	Human	7.9	pIC50	=	7.9	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm030936t
		2331	2489	43	None	-2	12	Human	7.9	pIC50	=	7.9	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm030936t
		3957	2489	43	None	-2	12	Human	7.9	pIC50	=	7.9	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm030936t
		4992	2489	43	None	-2	12	Human	7.9	pIC50	=	7.9	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm030936t
		CHEMBL511	2489	43	None	-2	12	Human	7.9	pIC50	=	7.9	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm030936t
		DB06691	2489	43	None	-2	12	Human	7.9	pIC50	=	7.9	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm030936t
		10026300	167834	17	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligandBinding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligand	ChEMBL	441	2	0	7	3.3	CN1CCN(C2=Nc3ccccc3Oc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1	10.1021/jm991005d
		CHEMBL430798	167834	17	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligandBinding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligand	ChEMBL	441	2	0	7	3.3	CN1CCN(C2=Nc3ccccc3Oc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1	10.1021/jm991005d
		10141470	123557	0	None	-	0	Guinea pig	6.9	pIC50	=	6.9	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	494	8	1	5	6.4	O=C(O)c1ccccc1OCCN1CCC(c2cn(Cc3ccc(Cl)s3)c3ccccc23)CC1	10.1021/jm0498203
		CHEMBL361805	123557	0	None	-	0	Guinea pig	6.9	pIC50	=	6.9	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	494	8	1	5	6.4	O=C(O)c1ccccc1OCCN1CCC(c2cn(Cc3ccc(Cl)s3)c3ccccc23)CC1	10.1021/jm0498203
		44392633	65576	0	None	-	0	Guinea pig	6.9	pIC50	=	6.9	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	454	9	1	4	6.1	CCCCn1cc(C2CCN(CCOc3cc(Cl)ccc3C(=O)O)CC2)c2ccccc21	10.1016/j.bmcl.2004.12.008
		CHEMBL183168	65576	0	None	-	0	Guinea pig	6.9	pIC50	=	6.9	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	454	9	1	4	6.1	CCCCn1cc(C2CCN(CCOc3cc(Cl)ccc3C(=O)O)CC2)c2ccccc21	10.1016/j.bmcl.2004.12.008
		9932752	141983	0	None	-	0	Guinea pig	6.9	pIC50	=	6.9	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	436	8	1	4	5.1	O=C(O)c1ccccc1OCCN1CCC(c2cn(CC3CC3)c3cc(F)ccc23)CC1	10.1021/jm0498203
		CHEMBL387391	141983	0	None	-	0	Guinea pig	6.9	pIC50	=	6.9	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	436	8	1	4	5.1	O=C(O)c1ccccc1OCCN1CCC(c2cn(CC3CC3)c3cc(F)ccc23)CC1	10.1021/jm0498203
		45485061	198754	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptorDisplacement of [3H]pyrilamine from human histamine H1 receptor	ChEMBL	489	5	2	5	5.0	Cc1cc(N(C)C)nc(N[C@H]2CC[C@@H](NC(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)n1	10.1016/j.bmcl.2009.09.003
		CHEMBL583014	198754	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptorDisplacement of [3H]pyrilamine from human histamine H1 receptor	ChEMBL	489	5	2	5	5.0	Cc1cc(N(C)C)nc(N[C@H]2CC[C@@H](NC(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)n1	10.1016/j.bmcl.2009.09.003
		45269073	196388	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	563	7	1	9	3.7	Cn1c(N2CCCN(CCCN3c4ccccc4Sc4ccc(C(C)(C)C(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmcl.2009.03.124
		CHEMBL562676	196388	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	563	7	1	9	3.7	Cn1c(N2CCCN(CCCN3c4ccccc4Sc4ccc(C(C)(C)C(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmcl.2009.03.124
		45269070	196616	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	493	5	1	9	2.2	Cn1c(N2CCN(CCN3c4ccccc4Sc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmcl.2009.03.124
		CHEMBL564168	196616	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	493	5	1	9	2.2	Cn1c(N2CCN(CCN3c4ccccc4Sc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmcl.2009.03.124
		4601	206747	35	None	-1	16	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
		CHEMBL1201023	206747	35	None	-1	16	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
		CHEMBL900	206747	35	None	-1	16	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
		10226501	137874	0	None	-	0	Guinea pig	6.9	pIC50	=	6.9	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	460	7	1	5	5.8	COc1ccc(CN2CCC(c3cn(Cc4cccs4)c4ccccc34)CC2)cc1C(=O)O	10.1021/jm0498203
		CHEMBL376202	137874	0	None	-	0	Guinea pig	6.9	pIC50	=	6.9	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	460	7	1	5	5.8	COc1ccc(CN2CCC(c3cn(Cc4cccs4)c4ccccc34)CC2)cc1C(=O)O	10.1021/jm0498203
		2284	3182	33	None	-10	29	Rat	5.9	pIC50	=	5.9	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1021/jm300671m
		4926	3182	33	None	-10	29	Rat	5.9	pIC50	=	5.9	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1021/jm300671m
		7281	3182	33	None	-10	29	Rat	5.9	pIC50	=	5.9	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1021/jm300671m
		CHEMBL564	3182	33	None	-10	29	Rat	5.9	pIC50	=	5.9	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1021/jm300671m
		DB00420	3182	33	None	-10	29	Rat	5.9	pIC50	=	5.9	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1021/jm300671m
		1197	88	120	None	-	1	Human	5.9	pIC50	=	5.9	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	122	2	1	2	0.6	NCCc1ccccn1	10.1021/jm030936t
		75919	88	120	None	-	1	Human	5.9	pIC50	=	5.9	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	122	2	1	2	0.6	NCCc1ccccn1	10.1021/jm030936t
		CHEMBL32813	88	120	None	-	1	Human	5.9	pIC50	=	5.9	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	122	2	1	2	0.6	NCCc1ccccn1	10.1021/jm030936t
		10890691	44716	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	262	12	1	2	4.5	NCCCCCCCCCCCCc1cccnc1	10.1021/jm030936t
		CHEMBL152122	44716	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	262	12	1	2	4.5	NCCCCCCCCCCCCc1cccnc1	10.1021/jm030936t
		11288570	49000	1	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	265	13	2	2	4.2	NCCCCCCCCCCCCCc1c[nH]cn1	10.1021/jm030936t
		CHEMBL156071	49000	1	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	265	13	2	2	4.2	NCCCCCCCCCCCCCc1c[nH]cn1	10.1021/jm030936t
		2142	3096	58	None	-7585	36	Rat	4.9	pIC50	=	4.9	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm300671m
		4920903	3096	58	None	-7585	36	Rat	4.9	pIC50	=	4.9	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm300671m
		502	3096	58	None	-7585	36	Rat	4.9	pIC50	=	4.9	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm300671m
		5775	3096	58	None	-7585	36	Rat	4.9	pIC50	=	4.9	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm300671m
		CHEMBL597	3096	58	None	-7585	36	Rat	4.9	pIC50	=	4.9	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm300671m
		DB00692	3096	58	None	-7585	36	Rat	4.9	pIC50	=	4.9	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm300671m
		9802248	166243	0	None	-	0	Guinea pig	6.9	pIC50	=	6.9	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	420	9	1	4	5.4	CCCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2ccccc21	10.1021/jm0498203
		CHEMBL426786	166243	0	None	-	0	Guinea pig	6.9	pIC50	=	6.9	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	420	9	1	4	5.4	CCCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2ccccc21	10.1021/jm0498203
		14762597	4343	0	None	-	0	Guinea pig	5.9	pIC50	=	5.9	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	392	4	2	3	3.4	O=C(CCN1CCN2Cc3[nH]c4ccccc4c3CC2C1)Nc1ccccc1F	10.1021/jm00173a011
		CHEMBL101029	4343	0	None	-	0	Guinea pig	5.9	pIC50	=	5.9	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	392	4	2	3	3.4	O=C(CCN1CCN2Cc3[nH]c4ccccc4c3CC2C1)Nc1ccccc1F	10.1021/jm00173a011
		54582401	61998	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	533	7	1	9	2.3	Cn1c(N2CCCN(CCCN3c4ccccc4COc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmc.2011.03.003
		CHEMBL1774493	61998	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	533	7	1	9	2.3	Cn1c(N2CCCN(CCCN3c4ccccc4COc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmc.2011.03.003
		54583384	61999	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	547	7	1	9	2.9	CC(C(=O)O)c1ccc2c(c1)N(CCCN1CCCN(c3cc(=O)n(C)c(=O)n3C)CC1)c1ccccc1CO2	10.1016/j.bmc.2011.03.003
		CHEMBL1774494	61999	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	547	7	1	9	2.9	CC(C(=O)O)c1ccc2c(c1)N(CCCN1CCCN(c3cc(=O)n(C)c(=O)n3C)CC1)c1ccccc1CO2	10.1016/j.bmc.2011.03.003
		11071079	110593	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	496	9	0	3	6.0	O=C(OCCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm010878g
		CHEMBL325516	110593	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	496	9	0	3	6.0	O=C(OCCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm010878g
		135398745	2914	112	None	1	65	Human	7.9	pIC50	=	7.9	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		47	2914	112	None	1	65	Human	7.9	pIC50	=	7.9	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		CHEMBL715	2914	112	None	1	65	Human	7.9	pIC50	=	7.9	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		DB00334	2914	112	None	1	65	Human	7.9	pIC50	=	7.9	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		135398745	2914	112	None	-1	65	Rat	7.9	pIC50	=	7.9	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1073/pnas.0611417104
		47	2914	112	None	-1	65	Rat	7.9	pIC50	=	7.9	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1073/pnas.0611417104
		CHEMBL715	2914	112	None	-1	65	Rat	7.9	pIC50	=	7.9	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1073/pnas.0611417104
		DB00334	2914	112	None	-1	65	Rat	7.9	pIC50	=	7.9	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1073/pnas.0611417104
		44461622	205943	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Binding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligandBinding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligand	ChEMBL	322	4	0	3	4.2	CCN(CC)CC1CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
		CHEMBL84293	205943	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Binding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligandBinding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligand	ChEMBL	322	4	0	3	4.2	CCN(CC)CC1CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
		11476077	136407	0	None	-	0	Guinea pig	6.9	pIC50	=	6.9	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	436	10	1	5	4.5	CCOCCn1cc(C2CCN(Cc3cccc(OCC(=O)O)c3)CC2)c2ccccc21	10.1021/jm0498203
		CHEMBL373534	136407	0	None	-	0	Guinea pig	6.9	pIC50	=	6.9	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	436	10	1	5	4.5	CCOCCn1cc(C2CCN(Cc3cccc(OCC(=O)O)c3)CC2)c2ccccc21	10.1021/jm0498203
		137125241	123063	30	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Selectivity interaction (Receptor panel (Novartis) ) EUB0000164c HRH1Selectivity interaction (Receptor panel (Novartis) ) EUB0000164c HRH1	ChEMBL	479	4	2	4	5.1	CC(C)NC(=O)N1CC[C@H](NC2=Nc3cc(F)ccc3N(CC(F)F)c3ccc(Cl)cc32)C1	10.6019/CHEMBL5212743
		CHEMBL3609372	123063	30	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Selectivity interaction (Receptor panel (Novartis) ) EUB0000164c HRH1Selectivity interaction (Receptor panel (Novartis) ) EUB0000164c HRH1	ChEMBL	479	4	2	4	5.1	CC(C)NC(=O)N1CC[C@H](NC2=Nc3cc(F)ccc3N(CC(F)F)c3ccc(Cl)cc32)C1	10.6019/CHEMBL5212743
		14762603	4196	0	None	-	0	Guinea pig	5.9	pIC50	=	5.9	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	380	5	1	5	2.7	O=C(CCN1CCN2Cc3ccccc3CC2C1)Nc1ccccc1[N+](=O)[O-]	10.1021/jm00173a011
		CHEMBL100169	4196	0	None	-	0	Guinea pig	5.9	pIC50	=	5.9	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	380	5	1	5	2.7	O=C(CCN1CCN2Cc3ccccc3CC2C1)Nc1ccccc1[N+](=O)[O-]	10.1021/jm00173a011
		14762570	4288	3	None	-	0	Guinea pig	5.9	pIC50	=	5.9	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	368	7	1	5	2.1	O=C(NCCN1CCN(Cc2ccccc2)CC1)c1ccccc1[N+](=O)[O-]	10.1021/jm00173a011
		CHEMBL100695	4288	3	None	-	0	Guinea pig	5.9	pIC50	=	5.9	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	368	7	1	5	2.1	O=C(NCCN1CCN(Cc2ccccc2)CC1)c1ccccc1[N+](=O)[O-]	10.1021/jm00173a011
		771426	4384	17	None	-	0	Guinea pig	5.9	pIC50	=	5.9	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	341	6	1	3	3.0	O=C(CCN1CCN(Cc2ccccc2)CC1)Nc1ccccc1F	10.1021/jm00173a011
		CHEMBL101312	4384	17	None	-	0	Guinea pig	5.9	pIC50	=	5.9	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	341	6	1	3	3.0	O=C(CCN1CCN(Cc2ccccc2)CC1)Nc1ccccc1F	10.1021/jm00173a011
		14762602	4171	0	None	-	0	Guinea pig	5.9	pIC50	=	5.9	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	335	4	1	3	2.8	O=C(CCN1CCN2Cc3ccccc3CC2C1)Nc1ccccc1	10.1021/jm00173a011
		CHEMBL100064	4171	0	None	-	0	Guinea pig	5.9	pIC50	=	5.9	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	335	4	1	3	2.8	O=C(CCN1CCN2Cc3ccccc3CC2C1)Nc1ccccc1	10.1021/jm00173a011
		3151	1462	97	None	-41	27	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		945	1462	97	None	-41	27	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		965	1462	97	None	-41	27	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		CHEMBL219916	1462	97	None	-41	27	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		DB01184	1462	97	None	-41	27	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		54581387	62011	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	528	6	1	7	2.8	Cn1c(N2CCCN(CC/C=C3/c4ccccc4CCc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmc.2011.03.003
		CHEMBL1774506	62011	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	528	6	1	7	2.8	Cn1c(N2CCCN(CC/C=C3/c4ccccc4CCc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmc.2011.03.003
		44392585	122612	0	None	-	0	Guinea pig	6.9	pIC50	=	6.9	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	528	8	1	5	7.0	O=C(O)c1ccc(Cl)cc1OCCN1CCC(c2cn(Cc3ccc(Cl)s3)c3ccccc23)CC1	10.1016/j.bmcl.2004.12.008
		CHEMBL360270	122612	0	None	-	0	Guinea pig	6.9	pIC50	=	6.9	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	528	8	1	5	7.0	O=C(O)c1ccc(Cl)cc1OCCN1CCC(c2cn(Cc3ccc(Cl)s3)c3ccccc23)CC1	10.1016/j.bmcl.2004.12.008
		2247	505	81	None	-4	42	Human	7.9	pIC50	=	7.9	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		249	505	81	None	-4	42	Human	7.9	pIC50	=	7.9	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		2603	505	81	None	-4	42	Human	7.9	pIC50	=	7.9	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		CHEMBL296419	505	81	None	-4	42	Human	7.9	pIC50	=	7.9	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		DB00637	505	81	None	-4	42	Human	7.9	pIC50	=	7.9	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		44319119	106967	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.	ChEMBL	324	3	0	4	3.4	COc1ccc2c(c1)C1CC(CN(C)C)ON1c1ccccc1C2	10.1016/s0960-894x(01)00721-1
		CHEMBL315044	106967	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.	ChEMBL	324	3	0	4	3.4	COc1ccc2c(c1)C1CC(CN(C)C)ON1c1ccccc1C2	10.1016/s0960-894x(01)00721-1
		9823337	137264	0	None	-	0	Guinea pig	6.9	pIC50	=	6.9	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	418	8	1	4	5.0	O=C(O)c1ccccc1OCCN1CCC(c2cn(CC3CC3)c3ccccc23)CC1	10.1021/jm0498203
		CHEMBL375208	137264	0	None	-	0	Guinea pig	6.9	pIC50	=	6.9	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	418	8	1	4	5.0	O=C(O)c1ccccc1OCCN1CCC(c2cn(CC3CC3)c3ccccc23)CC1	10.1021/jm0498203
		11362693	141612	0	None	-	0	Guinea pig	6.9	pIC50	=	6.9	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	440	9	1	5	4.4	COCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2ccc(F)cc21	10.1021/jm0498203
		CHEMBL385133	141612	0	None	-	0	Guinea pig	6.9	pIC50	=	6.9	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	440	9	1	5	4.4	COCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2ccc(F)cc21	10.1021/jm0498203
		54581386	61995	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	505	6	1	9	2.0	Cn1c(N2CCN(CCCN3c4ccccc4COc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmc.2011.03.003
		CHEMBL1774490	61995	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	505	6	1	9	2.0	Cn1c(N2CCN(CCCN3c4ccccc4COc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmc.2011.03.003
		9889247	84761	0	None	-	0	Guinea pig	6.8	pIC50	=	6.8	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	436	10	1	5	4.6	CCOCCn1cc(C2CCN(CCOc3cccc(C(=O)O)c3)CC2)c2ccccc21	10.1021/jm0498203
		CHEMBL223024	84761	0	None	-	0	Guinea pig	6.8	pIC50	=	6.8	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	436	10	1	5	4.6	CCOCCn1cc(C2CCN(CCOc3cccc(C(=O)O)c3)CC2)c2ccccc21	10.1021/jm0498203
		10478188	122942	0	None	-	0	Guinea pig	6.8	pIC50	=	6.8	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	436	9	1	5	4.8	CCOCCn1cc(C2CCN(Cc3ccc(OC)c(C(=O)O)c3)CC2)c2ccccc21	10.1021/jm0498203
		CHEMBL360712	122942	0	None	-	0	Guinea pig	6.8	pIC50	=	6.8	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	436	9	1	5	4.8	CCOCCn1cc(C2CCN(Cc3ccc(OC)c(C(=O)O)c3)CC2)c2ccccc21	10.1021/jm0498203
		5624	32693	14	None	-5	10	Human	4.8	pIC50	=	4.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	520	5	1	8	4.2	Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2	nan
		CHEMBL1203324	32693	14	None	-5	10	Human	4.8	pIC50	=	4.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	520	5	1	8	4.2	Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2	nan
		CHEMBL141343	32693	14	None	-5	10	Human	4.8	pIC50	=	4.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	520	5	1	8	4.2	Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2	nan
		1170	1633	75	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Inhibition of histamine H1 receptor (unknown origin)Inhibition of histamine H1 receptor (unknown origin)	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1021/jm501535r
		3348	1633	75	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Inhibition of histamine H1 receptor (unknown origin)Inhibition of histamine H1 receptor (unknown origin)	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1021/jm501535r
		4819	1633	75	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Inhibition of histamine H1 receptor (unknown origin)Inhibition of histamine H1 receptor (unknown origin)	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1021/jm501535r
		74685737	1633	75	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Inhibition of histamine H1 receptor (unknown origin)Inhibition of histamine H1 receptor (unknown origin)	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1021/jm501535r
		CHEMBL914	1633	75	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Inhibition of histamine H1 receptor (unknown origin)Inhibition of histamine H1 receptor (unknown origin)	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1021/jm501535r
		DB00950	1633	75	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Inhibition of histamine H1 receptor (unknown origin)Inhibition of histamine H1 receptor (unknown origin)	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1021/jm501535r
		44318834	106151	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.	ChEMBL	328	2	0	3	4.1	CN(C)CC1CC2c3ccccc3Cc3cccc(Cl)c3N2O1	10.1016/s0960-894x(01)00721-1
		CHEMBL313604	106151	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.	ChEMBL	328	2	0	3	4.1	CN(C)CC1CC2c3ccccc3Cc3cccc(Cl)c3N2O1	10.1016/s0960-894x(01)00721-1
		44318820	206038	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.	ChEMBL	308	2	0	3	3.7	Cc1ccc2c(c1)Cc1ccccc1N1OC(CN(C)C)CC21	10.1016/s0960-894x(01)00721-1
		CHEMBL85155	206038	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.	ChEMBL	308	2	0	3	3.7	Cc1ccc2c(c1)Cc1ccccc1N1OC(CN(C)C)CC21	10.1016/s0960-894x(01)00721-1
		2865	4143	73	None	-1047	53	Rat	6.8	pIC50	=	6.8	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1073/pnas.0611417104
		59	4143	73	None	-1047	53	Rat	6.8	pIC50	=	6.8	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1073/pnas.0611417104
		60854	4143	73	None	-1047	53	Rat	6.8	pIC50	=	6.8	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1073/pnas.0611417104
		CHEMBL708	4143	73	None	-1047	53	Rat	6.8	pIC50	=	6.8	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1073/pnas.0611417104
		DB00246	4143	73	None	-1047	53	Rat	6.8	pIC50	=	6.8	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1073/pnas.0611417104
		10279311	84351	0	None	-	0	Guinea pig	6.8	pIC50	=	6.8	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	512	7	1	5	6.6	COc1ccc(CN2CCC(c3cn(Cc4ccc(Cl)s4)c4cc(F)ccc34)CC2)cc1C(=O)O	10.1021/jm0498203
		CHEMBL221730	84351	0	None	-	0	Guinea pig	6.8	pIC50	=	6.8	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	512	7	1	5	6.6	COc1ccc(CN2CCC(c3cn(Cc4ccc(Cl)s4)c4cc(F)ccc34)CC2)cc1C(=O)O	10.1021/jm0498203
		11212029	84619	0	None	-	0	Guinea pig	6.8	pIC50	=	6.8	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	410	7	1	4	4.5	COCCn1cc(C2CCN(Cc3cccc(C(=O)O)c3)CC2)c2ccc(F)cc21	10.1021/jm0498203
		CHEMBL222142	84619	0	None	-	0	Guinea pig	6.8	pIC50	=	6.8	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	410	7	1	4	4.5	COCCn1cc(C2CCN(Cc3cccc(C(=O)O)c3)CC2)c2ccc(F)cc21	10.1021/jm0498203
		9889248	84730	0	None	-	0	Guinea pig	6.8	pIC50	=	6.8	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	436	10	1	5	4.6	CCOCCn1cc(C2CCN(CCOc3ccc(C(=O)O)cc3)CC2)c2ccccc21	10.1021/jm0498203
		CHEMBL222853	84730	0	None	-	0	Guinea pig	6.8	pIC50	=	6.8	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	436	10	1	5	4.6	CCOCCn1cc(C2CCN(CCOc3ccc(C(=O)O)cc3)CC2)c2ccccc21	10.1021/jm0498203
		11329754	141982	0	None	-	0	Guinea pig	6.8	pIC50	=	6.8	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	514	10	1	5	5.4	CCOCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2cc(Br)ccc21	10.1021/jm0498203
		CHEMBL387390	141982	0	None	-	0	Guinea pig	6.8	pIC50	=	6.8	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	514	10	1	5	5.4	CCOCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2cc(Br)ccc21	10.1021/jm0498203
		1305	511	14	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptorDisplacement of [3H]pyrilamine from human histamine H1 receptor	ChEMBL	425	5	2	5	4.1	O=C(c1ccc(c(c1)F)F)N[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C	10.1016/j.bmcl.2009.09.003
		9934033	511	14	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptorDisplacement of [3H]pyrilamine from human histamine H1 receptor	ChEMBL	425	5	2	5	4.1	O=C(c1ccc(c(c1)F)F)N[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C	10.1016/j.bmcl.2009.09.003
		CHEMBL182150	511	14	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptorDisplacement of [3H]pyrilamine from human histamine H1 receptor	ChEMBL	425	5	2	5	4.1	O=C(c1ccc(c(c1)F)F)N[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C	10.1016/j.bmcl.2009.09.003
		54586253	62000	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	561	7	1	9	3.1	Cn1c(N2CCCN(CCCN3c4ccccc4COc4ccc(C(C)(C)C(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmc.2011.03.003
		CHEMBL1774495	62000	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	561	7	1	9	3.1	Cn1c(N2CCCN(CCCN3c4ccccc4COc4ccc(C(C)(C)C(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmc.2011.03.003
		44461613	104223	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligandBinding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligand	ChEMBL	350	4	0	3	5.0	CC(C)N(CC1CC2c3ccccc3Cc3ccccc3N2O1)C(C)C	10.1016/s0960-894x(01)00721-1
		CHEMBL309904	104223	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligandBinding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligand	ChEMBL	350	4	0	3	5.0	CC(C)N(CC1CC2c3ccccc3Cc3ccccc3N2O1)C(C)C	10.1016/s0960-894x(01)00721-1
		14762593	4679	7	None	-	0	Guinea pig	5.8	pIC50	=	5.8	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	322	6	1	2	4.0	O=C(CCN1CCC(Cc2ccccc2)CC1)Nc1ccccc1	10.1021/jm00173a011
		CHEMBL103303	4679	7	None	-	0	Guinea pig	5.8	pIC50	=	5.8	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	322	6	1	2	4.0	O=C(CCN1CCC(Cc2ccccc2)CC1)Nc1ccccc1	10.1021/jm00173a011
		54587282	62012	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	514	5	1	7	2.9	Cn1c(N2CCCN(CC/C=C3/c4ccccc4CCc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmc.2011.03.003
		CHEMBL1774507	62012	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	514	5	1	7	2.9	Cn1c(N2CCCN(CC/C=C3/c4ccccc4CCc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmc.2011.03.003
		14762579	4398	0	None	-	0	Guinea pig	5.8	pIC50	=	5.8	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	322	6	1	2	3.4	O=C(NCCN1CCC(Cc2ccccc2)CC1)c1ccccc1	10.1021/jm00173a011
		CHEMBL101388	4398	0	None	-	0	Guinea pig	5.8	pIC50	=	5.8	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	322	6	1	2	3.4	O=C(NCCN1CCC(Cc2ccccc2)CC1)c1ccccc1	10.1021/jm00173a011
		11351801	84349	0	None	-	0	Guinea pig	6.8	pIC50	=	6.8	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	466	11	1	6	4.6	CCOCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2cc(OC)ccc21	10.1021/jm0498203
		CHEMBL221716	84349	0	None	-	0	Guinea pig	6.8	pIC50	=	6.8	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	466	11	1	6	4.6	CCOCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2cc(OC)ccc21	10.1021/jm0498203
		12488	1657	56	None	-2	23	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		941361	1657	56	None	-2	23	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		CHEMBL30008	1657	56	None	-2	23	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		DB04841	1657	56	None	-2	23	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		1204	1932	119	None	-501	24	Human	6.8	pIC50	=	6.8	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm030936t
		1247	1932	119	None	-501	24	Human	6.8	pIC50	=	6.8	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm030936t
		1375	1932	119	None	-501	24	Human	6.8	pIC50	=	6.8	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm030936t
		774	1932	119	None	-501	24	Human	6.8	pIC50	=	6.8	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm030936t
		CHEMBL90	1932	119	None	-501	24	Human	6.8	pIC50	=	6.8	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm030936t
		DB05381	1932	119	None	-501	24	Human	6.8	pIC50	=	6.8	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm030936t
		4098	32505	30	None	1	11	Human	7.8	pIC50	=	7.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
		CHEMBL1255739	32505	30	None	1	11	Human	7.8	pIC50	=	7.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
		CHEMBL1411979	32505	30	None	1	11	Human	7.8	pIC50	=	7.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
		44345317	113067	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity against Histamine H1 receptorBinding affinity against Histamine H1 receptor	ChEMBL	295	2	0	4	2.8	CN(C)CC1CC2c3cccnc3Cc3ccccc3N2O1	10.1016/s0960-894x(02)00796-5
		CHEMBL331188	113067	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity against Histamine H1 receptorBinding affinity against Histamine H1 receptor	ChEMBL	295	2	0	4	2.8	CN(C)CC1CC2c3cccnc3Cc3ccccc3N2O1	10.1016/s0960-894x(02)00796-5
		10246054	106544	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.	ChEMBL	330	2	0	3	3.7	CN(C)CC1CC2c3cc(F)ccc3Cc3ccc(F)cc3N2O1	10.1016/s0960-894x(01)00721-1
		CHEMBL314107	106544	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.	ChEMBL	330	2	0	3	3.7	CN(C)CC1CC2c3cc(F)ccc3Cc3ccc(F)cc3N2O1	10.1016/s0960-894x(01)00721-1
		1588	2325	27	None	-35	44	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		28864	2325	27	None	-35	44	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		43	2325	27	None	-35	44	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		CHEMBL157138	2325	27	None	-35	44	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		DB00589	2325	27	None	-35	44	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		45485062	197168	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptorDisplacement of [3H]pyrilamine from human histamine H1 receptor	ChEMBL	367	5	2	5	3.3	Cc1cccc(C(=O)N[C@H]2CC[C@@H](Nc3ncc(C)c(N(C)C)n3)CC2)c1	10.1016/j.bmcl.2009.09.003
		CHEMBL567993	197168	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptorDisplacement of [3H]pyrilamine from human histamine H1 receptor	ChEMBL	367	5	2	5	3.3	Cc1cccc(C(=O)N[C@H]2CC[C@@H](Nc3ncc(C)c(N(C)C)n3)CC2)c1	10.1016/j.bmcl.2009.09.003
		124087	1389	114	None	3	15	Human	4.8	pIC50	=	4.8	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		7157	1389	114	None	3	15	Human	4.8	pIC50	=	4.8	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		814	1389	114	None	3	15	Human	4.8	pIC50	=	4.8	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		CHEMBL1172	1389	114	None	3	15	Human	4.8	pIC50	=	4.8	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		DB00967	1389	114	None	3	15	Human	4.8	pIC50	=	4.8	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		124087	1389	114	None	3	15	Human	4.8	pIC50	=	4.8	Binding	Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		7157	1389	114	None	3	15	Human	4.8	pIC50	=	4.8	Binding	Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		814	1389	114	None	3	15	Human	4.8	pIC50	=	4.8	Binding	Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		CHEMBL1172	1389	114	None	3	15	Human	4.8	pIC50	=	4.8	Binding	Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		DB00967	1389	114	None	3	15	Human	4.8	pIC50	=	4.8	Binding	Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		14762598	4314	0	None	-	0	Guinea pig	5.8	pIC50	=	5.8	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	374	4	2	3	3.2	O=C(CCN1CCN2Cc3[nH]c4ccccc4c3CC2C1)Nc1ccccc1	10.1021/jm00173a011
		CHEMBL100865	4314	0	None	-	0	Guinea pig	5.8	pIC50	=	5.8	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	374	4	2	3	3.2	O=C(CCN1CCN2Cc3[nH]c4ccccc4c3CC2C1)Nc1ccccc1	10.1021/jm00173a011
		4601	206747	35	None	-	16	Rat	6.8	pIC50	=	6.8	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1021/jm300671m
		CHEMBL1201023	206747	35	None	-	16	Rat	6.8	pIC50	=	6.8	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1021/jm300671m
		CHEMBL900	206747	35	None	-	16	Rat	6.8	pIC50	=	6.8	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1021/jm300671m
		11113605	10507	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	480	9	0	2	5.8	O=C(CCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm010878g
		CHEMBL116735	10507	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	480	9	0	2	5.8	O=C(CCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm010878g
		2031	120433	31	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	ChEMBL	311	8	0	3	3.7	CCN(CC)CCOC(=O)C(c1ccccc1)c1ccccc1	10.1021/jm300671m
		CHEMBL353846	120433	31	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	ChEMBL	311	8	0	3	3.7	CCN(CC)CCOC(=O)C(c1ccccc1)c1ccccc1	10.1021/jm300671m
		2726	919	68	None	-2	72	Human	7.8	pIC50	=	7.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		621	919	68	None	-2	72	Human	7.8	pIC50	=	7.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		83	919	68	None	-2	72	Human	7.8	pIC50	=	7.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		CHEMBL71	919	68	None	-2	72	Human	7.8	pIC50	=	7.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		DB00477	919	68	None	-2	72	Human	7.8	pIC50	=	7.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		155536195	172164	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	504	7	1	5	5.6	CCOc1ccccc1OCC(O)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/j.bmcl.2019.126712
		CHEMBL4473399	172164	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	504	7	1	5	5.6	CCOc1ccccc1OCC(O)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/j.bmcl.2019.126712
		1605	2342	117	None	-2	4	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
		3957	2342	117	None	-2	4	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
		7216	2342	117	None	-2	4	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
		CHEMBL998	2342	117	None	-2	4	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
		DB00455	2342	117	None	-2	4	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
		23027035	198547	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptorDisplacement of [3H]pyrilamine from human histamine H1 receptor	ChEMBL	367	5	2	5	3.3	Cc1ccc(C(=O)N[C@H]2CC[C@@H](Nc3ncc(C)c(N(C)C)n3)CC2)cc1	10.1016/j.bmcl.2009.09.003
		CHEMBL578170	198547	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptorDisplacement of [3H]pyrilamine from human histamine H1 receptor	ChEMBL	367	5	2	5	3.3	Cc1ccc(C(=O)N[C@H]2CC[C@@H](Nc3ncc(C)c(N(C)C)n3)CC2)cc1	10.1016/j.bmcl.2009.09.003
		44392612	66685	0	None	-	0	Guinea pig	6.8	pIC50	=	6.8	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	474	9	1	6	5.2	COc1ccc(C(=O)O)c(OCCN2CCC(c3cn(Cc4ccoc4)c4ccccc34)CC2)c1	10.1016/j.bmcl.2004.12.008
		CHEMBL185454	66685	0	None	-	0	Guinea pig	6.8	pIC50	=	6.8	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	474	9	1	6	5.2	COc1ccc(C(=O)O)c(OCCN2CCC(c3cn(Cc4ccoc4)c4ccccc34)CC2)c1	10.1016/j.bmcl.2004.12.008
		126963284	144774	0	None	-	1	Human	4.8	pIC50	=	4.8	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.	ChEMBL	311	1	1	3	4.2	CO[C@H]1Cc2ccccc2C(=C2CCNCC2)c2ccsc21	nan
		CHEMBL3909134	144774	0	None	-	1	Human	4.8	pIC50	=	4.8	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.	ChEMBL	311	1	1	3	4.2	CO[C@H]1Cc2ccccc2C(=C2CCNCC2)c2ccsc21	nan
		121237834	147359	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	297	0	2	3	3.5	O[C@H]1Cc2ccccc2C(=C2CCNCC2)c2ccsc21	nan
		CHEMBL3929465	147359	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	297	0	2	3	3.5	O[C@H]1Cc2ccccc2C(=C2CCNCC2)c2ccsc21	nan
		14762588	4360	2	None	-	0	Guinea pig	5.8	pIC50	=	5.8	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	368	7	1	5	2.7	O=C(CCN1CCN(Cc2ccccc2)CC1)Nc1ccccc1[N+](=O)[O-]	10.1021/jm00173a011
		CHEMBL101122	4360	2	None	-	0	Guinea pig	5.8	pIC50	=	5.8	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	368	7	1	5	2.7	O=C(CCN1CCN(Cc2ccccc2)CC1)Nc1ccccc1[N+](=O)[O-]	10.1021/jm00173a011
		1224	1432	83	None	-2	13	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		3100	1432	83	None	-2	13	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		8980	1432	83	None	-2	13	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		916	1432	83	None	-2	13	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		CHEMBL657	1432	83	None	-2	13	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		DB01075	1432	83	None	-2	13	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		14762599	4197	0	None	-	0	Guinea pig	5.8	pIC50	=	5.8	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	419	5	2	5	3.1	O=C(CCN1CCN2Cc3[nH]c4ccccc4c3CC2C1)Nc1ccccc1[N+](=O)[O-]	10.1021/jm00173a011
		CHEMBL100170	4197	0	None	-	0	Guinea pig	5.8	pIC50	=	5.8	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	419	5	2	5	3.1	O=C(CCN1CCN2Cc3[nH]c4ccccc4c3CC2C1)Nc1ccccc1[N+](=O)[O-]	10.1021/jm00173a011
		2712	916	34	None	-5	4	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	299	1	1	3	3.0	CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl	nan
		3370	916	34	None	-5	4	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	299	1	1	3	3.0	CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl	nan
		594	916	34	None	-5	4	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	299	1	1	3	3.0	CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl	nan
		CHEMBL451	916	34	None	-5	4	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	299	1	1	3	3.0	CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl	nan
		DB00475	916	34	None	-5	4	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	299	1	1	3	3.0	CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl	nan
		10907460	9828	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	521	11	1	3	5.8	CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
		CHEMBL113956	9828	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	521	11	1	3	5.8	CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
		11340290	64364	0	None	-	0	Guinea pig	6.7	pIC50	=	6.7	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	466	11	1	6	4.6	CCOCCn1cc(C2CCN(CCOc3cc(OC)ccc3C(=O)O)CC2)c2ccccc21	10.1016/j.bmcl.2004.12.008
		CHEMBL181278	64364	0	None	-	0	Guinea pig	6.7	pIC50	=	6.7	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	466	11	1	6	4.6	CCOCCn1cc(C2CCN(CCOc3cc(OC)ccc3C(=O)O)CC2)c2ccccc21	10.1016/j.bmcl.2004.12.008
		11282005	66066	0	None	-	0	Guinea pig	6.7	pIC50	=	6.7	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	436	10	1	5	4.6	CCOCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2ccccc21	10.1016/j.bmcl.2004.12.008
		CHEMBL183706	66066	0	None	-	0	Guinea pig	6.7	pIC50	=	6.7	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	436	10	1	5	4.6	CCOCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2ccccc21	10.1016/j.bmcl.2004.12.008
		11730467	11028	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	476	10	0	2	6.0	O=C(CCCc1ccccc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm010878g
		CHEMBL117537	11028	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	476	10	0	2	6.0	O=C(CCCc1ccccc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm010878g
		54586257	62010	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	514	6	1	7	2.5	Cn1c(N2CCN(CC/C=C3/c4ccccc4CCc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmc.2011.03.003
		CHEMBL1774505	62010	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	514	6	1	7	2.5	Cn1c(N2CCN(CC/C=C3/c4ccccc4CCc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmc.2011.03.003
		11430513	84631	0	None	-	0	Guinea pig	6.7	pIC50	=	6.7	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	436	10	1	5	4.5	CCOCCn1cc(C2CCN(Cc3ccccc3OCC(=O)O)CC2)c2ccccc21	10.1021/jm0498203
		CHEMBL222217	84631	0	None	-	0	Guinea pig	6.7	pIC50	=	6.7	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	436	10	1	5	4.5	CCOCCn1cc(C2CCN(Cc3ccccc3OCC(=O)O)CC2)c2ccccc21	10.1021/jm0498203
		19426632	205858	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligandBinding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligand	ChEMBL	266	1	1	3	2.8	NCC1CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
		CHEMBL83731	205858	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligandBinding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligand	ChEMBL	266	1	1	3	2.8	NCC1CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
		1195	46	5	None	-	1	Human	5.7	pIC50	=	5.7	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	221	3	2	2	2.2	NCCc1cnc([nH]1)c1cccc(c1)Cl	10.1021/jm030936t
		14827778	46	5	None	-	1	Human	5.7	pIC50	=	5.7	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	221	3	2	2	2.2	NCCc1cnc([nH]1)c1cccc(c1)Cl	10.1021/jm030936t
		CHEMBL287052	46	5	None	-	1	Human	5.7	pIC50	=	5.7	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	221	3	2	2	2.2	NCCc1cnc([nH]1)c1cccc(c1)Cl	10.1021/jm030936t
		11346501	48264	1	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	279	14	2	2	4.6	NCCCCCCCCCCCCCCc1c[nH]cn1	10.1021/jm030936t
		CHEMBL155314	48264	1	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	279	14	2	2	4.6	NCCCCCCCCCCCCCCc1c[nH]cn1	10.1021/jm030936t
		11264275	119468	2	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	209	9	2	2	2.6	NCCCCCCCCCc1c[nH]cn1	10.1021/jm030936t
		CHEMBL345185	119468	2	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	209	9	2	2	2.6	NCCCCCCCCCc1c[nH]cn1	10.1021/jm030936t
		1164	1630	26	None	-	12	Rat	4.7	pIC50	=	4.7	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	ChEMBL	336	6	0	2	4.1	CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1	10.1021/jm300671m
		1626	1630	26	None	-	12	Rat	4.7	pIC50	=	4.7	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	ChEMBL	336	6	0	2	4.1	CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1	10.1021/jm300671m
		3345	1630	26	None	-	12	Rat	4.7	pIC50	=	4.7	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	ChEMBL	336	6	0	2	4.1	CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1	10.1021/jm300671m
		CHEMBL596	1630	26	None	-	12	Rat	4.7	pIC50	=	4.7	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	ChEMBL	336	6	0	2	4.1	CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1	10.1021/jm300671m
		DB00813	1630	26	None	-	12	Rat	4.7	pIC50	=	4.7	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	ChEMBL	336	6	0	2	4.1	CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1	10.1021/jm300671m
		44290349	178537	0	None	131	2	Rat	8.7	pIC50	=	8.7	Binding	Compound was evaluated for binding activity against [3H]pyrilamine as radioligand for Histamine H1 receptorCompound was evaluated for binding activity against [3H]pyrilamine as radioligand for Histamine H1 receptor	ChEMBL	411	5	2	6	2.1	O=C(c1ccc(F)cc1)C1CCN(CCn2c(=O)[nH]c3cc(O)ccc3c2=O)CC1	10.1021/jm00159a017
		CHEMBL46683	178537	0	None	131	2	Rat	8.7	pIC50	=	8.7	Binding	Compound was evaluated for binding activity against [3H]pyrilamine as radioligand for Histamine H1 receptorCompound was evaluated for binding activity against [3H]pyrilamine as radioligand for Histamine H1 receptor	ChEMBL	411	5	2	6	2.1	O=C(c1ccc(F)cc1)C1CCN(CCn2c(=O)[nH]c3cc(O)ccc3c2=O)CC1	10.1021/jm00159a017
		44319120	205778	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.	ChEMBL	312	2	0	3	3.5	CN(C)CC1CC2c3cccc(F)c3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
		CHEMBL82966	205778	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.	ChEMBL	312	2	0	3	3.5	CN(C)CC1CC2c3cccc(F)c3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
		10381889	107069	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Binding affinity against Histamine H1 receptorBinding affinity against Histamine H1 receptor	ChEMBL	328	2	0	3	4.1	CN(C)CC1CC2c3ccccc3Cc3ccc(Cl)cc3N2O1	10.1016/s0960-894x(02)00796-5
		CHEMBL315772	107069	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Binding affinity against Histamine H1 receptorBinding affinity against Histamine H1 receptor	ChEMBL	328	2	0	3	4.1	CN(C)CC1CC2c3ccccc3Cc3ccc(Cl)cc3N2O1	10.1016/s0960-894x(02)00796-5
		10381889	107069	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.	ChEMBL	328	2	0	3	4.1	CN(C)CC1CC2c3ccccc3Cc3ccc(Cl)cc3N2O1	10.1016/s0960-894x(01)00721-1
		CHEMBL315772	107069	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.	ChEMBL	328	2	0	3	4.1	CN(C)CC1CC2c3ccccc3Cc3ccc(Cl)cc3N2O1	10.1016/s0960-894x(01)00721-1
		44318454	206009	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.	ChEMBL	312	2	0	3	3.5	CN(C)CC1CC2c3ccccc3Cc3ccc(F)cc3N2O1	10.1016/s0960-894x(01)00721-1
		CHEMBL84931	206009	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.	ChEMBL	312	2	0	3	3.5	CN(C)CC1CC2c3ccccc3Cc3ccc(F)cc3N2O1	10.1016/s0960-894x(01)00721-1
		2286	3183	51	None	-2	30	Human	8.5	pIC50	=	8.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		4927	3183	51	None	-2	30	Human	8.5	pIC50	=	8.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		7282	3183	51	None	-2	30	Human	8.5	pIC50	=	8.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		CHEMBL643	3183	51	None	-2	30	Human	8.5	pIC50	=	8.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		DB01069	3183	51	None	-2	30	Human	8.5	pIC50	=	8.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		155518920	170324	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	490	6	1	5	5.2	COc1ccccc1OCC(O)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/j.bmcl.2019.126712
		CHEMBL4446961	170324	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	490	6	1	5	5.2	COc1ccccc1OCC(O)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/j.bmcl.2019.126712
		155541322	173008	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	502	6	1	5	5.4	CC(=O)c1ccccc1OCC(O)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/j.bmcl.2019.126712
		CHEMBL4518271	173008	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	502	6	1	5	5.4	CC(=O)c1ccccc1OCC(O)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/j.bmcl.2019.126712
		10114407	123326	0	None	-	0	Guinea pig	6.7	pIC50	=	6.7	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	444	7	1	5	5.4	COc1ccc(CN2CCC(c3cn(Cc4ccoc4)c4ccccc34)CC2)cc1C(=O)O	10.1016/j.bmcl.2004.12.008
		CHEMBL361625	123326	0	None	-	0	Guinea pig	6.7	pIC50	=	6.7	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	444	7	1	5	5.4	COc1ccc(CN2CCC(c3cn(Cc4ccoc4)c4ccccc34)CC2)cc1C(=O)O	10.1016/j.bmcl.2004.12.008
		44332016	4244	0	None	-	0	Guinea pig	6.7	pIC50	=	6.7	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	261	0	1	2	2.4	ClN1CCN2Cc3[nH]c4ccccc4c3CC2C1	10.1021/jm00173a011
		CHEMBL100442	4244	0	None	-	0	Guinea pig	6.7	pIC50	=	6.7	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	261	0	1	2	2.4	ClN1CCN2Cc3[nH]c4ccccc4c3CC2C1	10.1021/jm00173a011
		13726483	95255	2	None	-	0	Guinea pig	4.7	pIC50	=	4.7	Binding	Inhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortex	ChEMBL	265	3	0	4	1.4	CN(C)CC[C@H]1CN(C)C(=S)c2cccnc2O1	10.1021/jm00108a012
		CHEMBL25622	95255	2	None	-	0	Guinea pig	4.7	pIC50	=	4.7	Binding	Inhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortex	ChEMBL	265	3	0	4	1.4	CN(C)CC[C@H]1CN(C)C(=S)c2cccnc2O1	10.1021/jm00108a012
		44392549	65356	0	None	-	0	Guinea pig	6.7	pIC50	=	6.7	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	450	10	1	5	5.4	CCCCn1cc(C2CCN(CCOc3cc(OC)ccc3C(=O)O)CC2)c2ccccc21	10.1016/j.bmcl.2004.12.008
		CHEMBL182922	65356	0	None	-	0	Guinea pig	6.7	pIC50	=	6.7	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	450	10	1	5	5.4	CCCCn1cc(C2CCN(CCOc3cc(OC)ccc3C(=O)O)CC2)c2ccccc21	10.1016/j.bmcl.2004.12.008
		739984	107204	15	None	-	0	Guinea pig	5.7	pIC50	=	5.7	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	323	6	1	3	2.8	O=C(CCN1CCN(Cc2ccccc2)CC1)Nc1ccccc1	10.1021/jm00173a011
		CHEMBL316616	107204	15	None	-	0	Guinea pig	5.7	pIC50	=	5.7	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	323	6	1	3	2.8	O=C(CCN1CCN(Cc2ccccc2)CC1)Nc1ccccc1	10.1021/jm00173a011
		9822631	122959	0	None	-	0	Guinea pig	6.7	pIC50	=	6.7	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	406	8	1	4	4.8	CCOCCn1cc(C2CCN(Cc3cccc(C(=O)O)c3)CC2)c2ccccc21	10.1021/jm0498203
		CHEMBL360791	122959	0	None	-	0	Guinea pig	6.7	pIC50	=	6.7	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	406	8	1	4	4.8	CCOCCn1cc(C2CCN(Cc3cccc(C(=O)O)c3)CC2)c2ccccc21	10.1021/jm0498203
		11202401	137107	0	None	-	0	Guinea pig	6.7	pIC50	=	6.7	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	478	11	1	6	4.8	CCOCCn1cc(C2CCN(CCOc3ccc(C(C)=O)cc3C(=O)O)CC2)c2ccccc21	10.1021/jm0498203
		CHEMBL374755	137107	0	None	-	0	Guinea pig	6.7	pIC50	=	6.7	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	478	11	1	6	4.8	CCOCCn1cc(C2CCN(CCOc3ccc(C(C)=O)cc3C(=O)O)CC2)c2ccccc21	10.1021/jm0498203
		2600	3779	74	None	1	13	Human	7.7	pIC50	=	7.7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		2608	3779	74	None	1	13	Human	7.7	pIC50	=	7.7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		5405	3779	74	None	1	13	Human	7.7	pIC50	=	7.7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		CHEMBL17157	3779	74	None	1	13	Human	7.7	pIC50	=	7.7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		DB00342	3779	74	None	1	13	Human	7.7	pIC50	=	7.7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		10369004	13688	0	None	-	0	Guinea pig	6.7	pIC50	=	6.7	Binding	Compound is evaluated for in vitro receptor binding affinity against H1 receptorCompound is evaluated for in vitro receptor binding affinity against H1 receptor	ChEMBL	508	7	0	8	2.5	Cn1c(=O)c2c(ncn2CCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)n(C)c1=O	10.1021/jm00020a018
		CHEMBL1194812	13688	0	None	-	0	Guinea pig	6.7	pIC50	=	6.7	Binding	Compound is evaluated for in vitro receptor binding affinity against H1 receptorCompound is evaluated for in vitro receptor binding affinity against H1 receptor	ChEMBL	508	7	0	8	2.5	Cn1c(=O)c2c(ncn2CCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)n(C)c1=O	10.1021/jm00020a018
		CHEMBL553331	13688	0	None	-	0	Guinea pig	6.7	pIC50	=	6.7	Binding	Compound is evaluated for in vitro receptor binding affinity against H1 receptorCompound is evaluated for in vitro receptor binding affinity against H1 receptor	ChEMBL	508	7	0	8	2.5	Cn1c(=O)c2c(ncn2CCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)n(C)c1=O	10.1021/jm00020a018
		11166846	84301	0	None	-	0	Guinea pig	6.7	pIC50	=	6.7	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	450	10	1	5	4.9	CCOCCn1cc(C2CCN(CCOc3ccc(C)cc3C(=O)O)CC2)c2ccccc21	10.1021/jm0498203
		CHEMBL221462	84301	0	None	-	0	Guinea pig	6.7	pIC50	=	6.7	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	450	10	1	5	4.9	CCOCCn1cc(C2CCN(CCOc3ccc(C)cc3C(=O)O)CC2)c2ccccc21	10.1021/jm0498203
		11238716	84292	0	None	-	0	Guinea pig	6.7	pIC50	=	6.7	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	592	10	1	5	6.2	CCOCCn1cc(C2CCN(CCOc3c(Br)cc(Br)cc3C(=O)O)CC2)c2ccccc21	10.1021/jm0498203
		CHEMBL221414	84292	0	None	-	0	Guinea pig	6.7	pIC50	=	6.7	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	592	10	1	5	6.2	CCOCCn1cc(C2CCN(CCOc3c(Br)cc(Br)cc3C(=O)O)CC2)c2ccccc21	10.1021/jm0498203
		10160717	168398	0	None	-	0	Guinea pig	6.7	pIC50	=	6.7	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	444	8	1	5	5.2	O=C(O)c1ccccc1OCCN1CCC(c2cn(Cc3ccoc3)c3ccccc23)CC1	10.1016/j.bmcl.2004.12.008
		CHEMBL434709	168398	0	None	-	0	Guinea pig	6.7	pIC50	=	6.7	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	444	8	1	5	5.2	O=C(O)c1ccccc1OCCN1CCC(c2cn(Cc3ccoc3)c3ccccc23)CC1	10.1016/j.bmcl.2004.12.008
		135398737	958	93	None	-4	89	Rat	7.6	pIC50	=	7.6	Binding	Binding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligandBinding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm991005d
		38	958	93	None	-4	89	Rat	7.6	pIC50	=	7.6	Binding	Binding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligandBinding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm991005d
		722	958	93	None	-4	89	Rat	7.6	pIC50	=	7.6	Binding	Binding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligandBinding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm991005d
		CHEMBL42	958	93	None	-4	89	Rat	7.6	pIC50	=	7.6	Binding	Binding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligandBinding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm991005d
		DB00363	958	93	None	-4	89	Rat	7.6	pIC50	=	7.6	Binding	Binding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligandBinding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm991005d
		45267326	195966	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	535	7	1	9	2.9	Cn1c(N2CCCN(CCCN3c4ccccc4Sc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmcl.2009.03.124
		CHEMBL559665	195966	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	535	7	1	9	2.9	Cn1c(N2CCCN(CCCN3c4ccccc4Sc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmcl.2009.03.124
		45268181	196645	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	521	6	1	9	3.0	Cn1c(N2CCCN(CCCN3c4ccccc4Sc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmcl.2009.03.124
		CHEMBL564370	196645	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	521	6	1	9	3.0	Cn1c(N2CCCN(CCCN3c4ccccc4Sc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmcl.2009.03.124
		135398737	958	93	None	-4	89	Rat	7.6	pIC50	=	7.6	Binding	Inhibitory binding of [3H]mepyramine to histamine H1 receptors in rat brain membranesInhibitory binding of [3H]mepyramine to histamine H1 receptors in rat brain membranes	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9704457
		38	958	93	None	-4	89	Rat	7.6	pIC50	=	7.6	Binding	Inhibitory binding of [3H]mepyramine to histamine H1 receptors in rat brain membranesInhibitory binding of [3H]mepyramine to histamine H1 receptors in rat brain membranes	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9704457
		722	958	93	None	-4	89	Rat	7.6	pIC50	=	7.6	Binding	Inhibitory binding of [3H]mepyramine to histamine H1 receptors in rat brain membranesInhibitory binding of [3H]mepyramine to histamine H1 receptors in rat brain membranes	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9704457
		CHEMBL42	958	93	None	-4	89	Rat	7.6	pIC50	=	7.6	Binding	Inhibitory binding of [3H]mepyramine to histamine H1 receptors in rat brain membranesInhibitory binding of [3H]mepyramine to histamine H1 receptors in rat brain membranes	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9704457
		DB00363	958	93	None	-4	89	Rat	7.6	pIC50	=	7.6	Binding	Inhibitory binding of [3H]mepyramine to histamine H1 receptors in rat brain membranesInhibitory binding of [3H]mepyramine to histamine H1 receptors in rat brain membranes	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9704457
		1530	2182	50	None	-5	21	Human	5.6	pIC50	=	5.6	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		3827	2182	50	None	-5	21	Human	5.6	pIC50	=	5.6	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		7206	2182	50	None	-5	21	Human	5.6	pIC50	=	5.6	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		CHEMBL534	2182	50	None	-5	21	Human	5.6	pIC50	=	5.6	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		DB00920	2182	50	None	-5	21	Human	5.6	pIC50	=	5.6	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		1530	2182	50	None	-5	21	Human	5.6	pIC50	=	5.6	Binding	Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		3827	2182	50	None	-5	21	Human	5.6	pIC50	=	5.6	Binding	Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		7206	2182	50	None	-5	21	Human	5.6	pIC50	=	5.6	Binding	Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		CHEMBL534	2182	50	None	-5	21	Human	5.6	pIC50	=	5.6	Binding	Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		DB00920	2182	50	None	-5	21	Human	5.6	pIC50	=	5.6	Binding	Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		126963283	160963	0	None	-	1	Human	4.6	pIC50	=	4.6	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.	ChEMBL	311	1	1	3	4.2	CO[C@@H]1Cc2ccccc2C(=C2CCNCC2)c2ccsc21	nan
		CHEMBL4115677	160963	0	None	-	1	Human	4.6	pIC50	=	4.6	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.	ChEMBL	311	1	1	3	4.2	CO[C@@H]1Cc2ccccc2C(=C2CCNCC2)c2ccsc21	nan
		11638166	8147	0	None	-	1	Human	4.6	pIC50	=	4.6	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	310	5	0	3	4.6	CC(c1ccncc1)c1c(CCN(C)C)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		CHEMBL1091790	8147	0	None	-	1	Human	4.6	pIC50	=	4.6	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	310	5	0	3	4.6	CC(c1ccncc1)c1c(CCN(C)C)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		11335478	160965	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	297	0	2	3	3.5	O[C@@H]1Cc2ccccc2C(=C2CCNCC2)c2ccsc21	nan
		CHEMBL4115693	160965	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	297	0	2	3	3.5	O[C@@H]1Cc2ccccc2C(=C2CCNCC2)c2ccsc21	nan
		9802248	166243	0	None	-	0	Guinea pig	6.6	pIC50	=	6.6	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	420	9	1	4	5.4	CCCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2ccccc21	10.1016/j.bmcl.2004.12.008
		CHEMBL426786	166243	0	None	-	0	Guinea pig	6.6	pIC50	=	6.6	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	420	9	1	4	5.4	CCCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2ccccc21	10.1016/j.bmcl.2004.12.008
		2274	3173	58	None	-3	31	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		4917	3173	58	None	-3	31	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		7279	3173	58	None	-3	31	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		CHEMBL728	3173	58	None	-3	31	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		DB00433	3173	58	None	-3	31	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		14842833	93303	0	None	-	0	Guinea pig	7.6	pIC50	=	7.6	Binding	Inhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortex	ChEMBL	275	5	0	3	3.2	CN(C)CCC(c1ccccn1)c1ccc(Cl)cn1	10.1021/jm00108a012
		CHEMBL24517	93303	0	None	-	0	Guinea pig	7.6	pIC50	=	7.6	Binding	Inhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortex	ChEMBL	275	5	0	3	3.2	CN(C)CCC(c1ccccn1)c1ccc(Cl)cn1	10.1021/jm00108a012
		44392620	126823	0	None	-	0	Guinea pig	6.6	pIC50	=	6.6	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	524	9	1	6	6.4	COc1ccc(C(=O)O)c(OCCN2CCC(c3cn(Cc4ccc(Cl)s4)c4ccccc34)CC2)c1	10.1016/j.bmcl.2004.12.008
		CHEMBL365450	126823	0	None	-	0	Guinea pig	6.6	pIC50	=	6.6	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	524	9	1	6	6.4	COc1ccc(C(=O)O)c(OCCN2CCC(c3cn(Cc4ccc(Cl)s4)c4ccccc34)CC2)c1	10.1016/j.bmcl.2004.12.008
		10003369	84336	0	None	-	0	Guinea pig	6.6	pIC50	=	6.6	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	440	8	1	5	4.5	COCCn1cc(C2CCN(Cc3ccc(OC)c(C(=O)O)c3)CC2)c2ccc(F)cc21	10.1021/jm0498203
		CHEMBL221678	84336	0	None	-	0	Guinea pig	6.6	pIC50	=	6.6	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	440	8	1	5	4.5	COCCn1cc(C2CCN(Cc3ccc(OC)c(C(=O)O)c3)CC2)c2ccc(F)cc21	10.1021/jm0498203
		2389	3331	118	None	-46	67	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		5073	3331	118	None	-46	67	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		96	3331	118	None	-46	67	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		CHEMBL85	3331	118	None	-46	67	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		DB00734	3331	118	None	-46	67	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		11333854	51605	1	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	237	11	2	2	3.4	NCCCCCCCCCCCc1c[nH]cn1	10.1021/jm030936t
		CHEMBL158352	51605	1	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	237	11	2	2	3.4	NCCCCCCCCCCCc1c[nH]cn1	10.1021/jm030936t
		11241807	51010	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	234	10	1	2	3.7	NCCCCCCCCCCc1cccnc1	10.1021/jm030936t
		CHEMBL157842	51010	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	234	10	1	2	3.7	NCCCCCCCCCCc1cccnc1	10.1021/jm030936t
		11253315	121965	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	234	10	1	2	3.7	NCCCCCCCCCCc1ccncc1	10.1021/jm030936t
		CHEMBL359122	121965	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	234	10	1	2	3.7	NCCCCCCCCCCc1ccncc1	10.1021/jm030936t
		54586252	61997	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	519	7	1	9	2.0	Cn1c(N2CCN(CCCN3c4ccccc4COc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmc.2011.03.003
		CHEMBL1774492	61997	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	519	7	1	9	2.0	Cn1c(N2CCN(CCCN3c4ccccc4COc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmc.2011.03.003
		127049862	140257	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Antagonistic activity at histamine1 receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at histamine1 receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	425	8	1	5	4.4	CNC(=O)c1cccc(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)c1	10.1016/j.bmcl.2016.04.087
		CHEMBL3805559	140257	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Antagonistic activity at histamine1 receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at histamine1 receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	425	8	1	5	4.4	CNC(=O)c1cccc(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)c1	10.1016/j.bmcl.2016.04.087
		44461800	205297	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligandBinding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligand	ChEMBL	336	2	0	4	3.2	c1ccc2c(c1)Cc1ccccc1N1OC(CN3CCOCC3)CC21	10.1016/s0960-894x(01)00721-1
		CHEMBL79249	205297	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligandBinding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligand	ChEMBL	336	2	0	4	3.2	c1ccc2c(c1)Cc1ccccc1N1OC(CN3CCOCC3)CC21	10.1016/s0960-894x(01)00721-1
		1427	2013	54	None	-5	27	Human	7.6	pIC50	=	7.6	Binding	Binding affinity to histamine H1 receptor (unknown origin) by radioligand binding assayBinding affinity to histamine H1 receptor (unknown origin) by radioligand binding assay	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1021/jm400856t
		357	2013	54	None	-5	27	Human	7.6	pIC50	=	7.6	Binding	Binding affinity to histamine H1 receptor (unknown origin) by radioligand binding assayBinding affinity to histamine H1 receptor (unknown origin) by radioligand binding assay	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1021/jm400856t
		3696	2013	54	None	-5	27	Human	7.6	pIC50	=	7.6	Binding	Binding affinity to histamine H1 receptor (unknown origin) by radioligand binding assayBinding affinity to histamine H1 receptor (unknown origin) by radioligand binding assay	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1021/jm400856t
		CHEMBL11	2013	54	None	-5	27	Human	7.6	pIC50	=	7.6	Binding	Binding affinity to histamine H1 receptor (unknown origin) by radioligand binding assayBinding affinity to histamine H1 receptor (unknown origin) by radioligand binding assay	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1021/jm400856t
		DB00458	2013	54	None	-5	27	Human	7.6	pIC50	=	7.6	Binding	Binding affinity to histamine H1 receptor (unknown origin) by radioligand binding assayBinding affinity to histamine H1 receptor (unknown origin) by radioligand binding assay	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1021/jm400856t
		6075	150108	42	None	2	16	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
		CHEMBL395110	150108	42	None	2	16	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
		155545724	173471	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	526	6	1	5	5.5	COc1c(OCC(O)CN2CCC(=C3c4ccc(Cl)cc4CCc4cccnc43)CC2)ccc(F)c1F	10.1016/j.bmcl.2019.126712
		CHEMBL4529928	173471	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	526	6	1	5	5.5	COc1c(OCC(O)CN2CCC(=C3c4ccc(Cl)cc4CCc4cccnc43)CC2)ccc(F)c1F	10.1016/j.bmcl.2019.126712
		44392599	65175	0	None	-	0	Guinea pig	6.6	pIC50	=	6.6	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	390	7	1	3	5.5	CCCCn1cc(C2CCN(Cc3cccc(C(=O)O)c3)CC2)c2ccccc21	10.1016/j.bmcl.2004.12.008
		CHEMBL182474	65175	0	None	-	0	Guinea pig	6.6	pIC50	=	6.6	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	390	7	1	3	5.5	CCCCn1cc(C2CCN(Cc3cccc(C(=O)O)c3)CC2)c2ccccc21	10.1016/j.bmcl.2004.12.008
		1353	1911	93	None	-489	83	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		3559	1911	93	None	-489	83	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		86	1911	93	None	-489	83	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		CHEMBL54	1911	93	None	-489	83	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		DB00502	1911	93	None	-489	83	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		11785584	136964	0	None	-	0	Guinea pig	7.6	pIC50	=	7.6	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	512	8	1	5	6.5	O=C(O)c1ccccc1OCCN1CCC(c2cn(Cc3ccc(Cl)s3)c3cc(F)ccc23)CC1	10.1021/jm0498203
		CHEMBL374459	136964	0	None	-	0	Guinea pig	7.6	pIC50	=	7.6	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	512	8	1	5	6.5	O=C(O)c1ccccc1OCCN1CCC(c2cn(Cc3ccc(Cl)s3)c3cc(F)ccc23)CC1	10.1021/jm0498203
		22322323	196017	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	440	7	1	7	2.7	Cn1c(NCCCN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)cc(=O)n(C)c1=O	10.1016/j.bmcl.2009.03.124
		CHEMBL560120	196017	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	440	7	1	7	2.7	Cn1c(NCCCN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)cc(=O)n(C)c1=O	10.1016/j.bmcl.2009.03.124
		3191	102858	97	None	2	25	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
		CHEMBL305660	102858	97	None	2	25	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
		155549722	173849	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	494	5	1	4	5.8	OC(COc1ccccc1Cl)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/j.bmcl.2019.126712
		CHEMBL4539056	173849	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	494	5	1	4	5.8	OC(COc1ccccc1Cl)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/j.bmcl.2019.126712
		10894144	110559	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	377	7	0	4	3.5	N#Cc1ccc(CCOC(=O)N2CCN(CCCc3ccccc3)CC2)cc1	10.1021/jm010878g
		CHEMBL325258	110559	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	377	7	0	4	3.5	N#Cc1ccc(CCOC(=O)N2CCN(CCCc3ccccc3)CC2)cc1	10.1021/jm010878g
		3038952	108911	2	None	-	0	Guinea pig	6.6	pIC50	=	6.6	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	241	0	1	2	1.8	CN1CCN2Cc3[nH]c4ccccc4c3CC2C1	10.1021/jm00173a011
		CHEMBL321104	108911	2	None	-	0	Guinea pig	6.6	pIC50	=	6.6	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	241	0	1	2	1.8	CN1CCN2Cc3[nH]c4ccccc4c3CC2C1	10.1021/jm00173a011
		76319448	85388	2	None	-	0	Guinea pig	4.5	pIC50	=	4.5	Binding	Inhibition of H1 receptor in Cavia porcellus Hartley (guinea pig) ileum assessed as inhibition of histamine-induced spasms incubated 2 min prior histamine-challengeInhibition of H1 receptor in Cavia porcellus Hartley (guinea pig) ileum assessed as inhibition of histamine-induced spasms incubated 2 min prior histamine-challenge	ChEMBL	221	4	4	4	0.7	CC(CO)(CO)Nc1nc2ccccc2[nH]1	10.1007/s00044-008-9119-y
		CHEMBL2262478	85388	2	None	-	0	Guinea pig	4.5	pIC50	=	4.5	Binding	Inhibition of H1 receptor in Cavia porcellus Hartley (guinea pig) ileum assessed as inhibition of histamine-induced spasms incubated 2 min prior histamine-challengeInhibition of H1 receptor in Cavia porcellus Hartley (guinea pig) ileum assessed as inhibition of histamine-induced spasms incubated 2 min prior histamine-challenge	ChEMBL	221	4	4	4	0.7	CC(CO)(CO)Nc1nc2ccccc2[nH]1	10.1007/s00044-008-9119-y
		1605	2342	117	None	-2	4	Human	6.5	pIC50	=	6.5	Binding	Inhibitory concentration against histamine H1 receptorInhibitory concentration against histamine H1 receptor	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1021/jm058225d
		3957	2342	117	None	-2	4	Human	6.5	pIC50	=	6.5	Binding	Inhibitory concentration against histamine H1 receptorInhibitory concentration against histamine H1 receptor	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1021/jm058225d
		7216	2342	117	None	-2	4	Human	6.5	pIC50	=	6.5	Binding	Inhibitory concentration against histamine H1 receptorInhibitory concentration against histamine H1 receptor	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1021/jm058225d
		CHEMBL998	2342	117	None	-2	4	Human	6.5	pIC50	=	6.5	Binding	Inhibitory concentration against histamine H1 receptorInhibitory concentration against histamine H1 receptor	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1021/jm058225d
		DB00455	2342	117	None	-2	4	Human	6.5	pIC50	=	6.5	Binding	Inhibitory concentration against histamine H1 receptorInhibitory concentration against histamine H1 receptor	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1021/jm058225d
		2812	4779	101	None	-28	34	Human	4.5	pIC50	=	4.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
		CHEMBL104	4779	101	None	-28	34	Human	4.5	pIC50	=	4.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
		2600	3779	74	None	-3	13	Guinea pig	6.5	pIC50	=	6.5	Binding	Inhibitory activity against Tritiated [3H]- mepyramine binding to histamine H1 receptor in guinea pig cerebral cortexInhibitory activity against Tritiated [3H]- mepyramine binding to histamine H1 receptor in guinea pig cerebral cortex	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1021/jm00121a022
		2608	3779	74	None	-3	13	Guinea pig	6.5	pIC50	=	6.5	Binding	Inhibitory activity against Tritiated [3H]- mepyramine binding to histamine H1 receptor in guinea pig cerebral cortexInhibitory activity against Tritiated [3H]- mepyramine binding to histamine H1 receptor in guinea pig cerebral cortex	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1021/jm00121a022
		5405	3779	74	None	-3	13	Guinea pig	6.5	pIC50	=	6.5	Binding	Inhibitory activity against Tritiated [3H]- mepyramine binding to histamine H1 receptor in guinea pig cerebral cortexInhibitory activity against Tritiated [3H]- mepyramine binding to histamine H1 receptor in guinea pig cerebral cortex	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1021/jm00121a022
		CHEMBL17157	3779	74	None	-3	13	Guinea pig	6.5	pIC50	=	6.5	Binding	Inhibitory activity against Tritiated [3H]- mepyramine binding to histamine H1 receptor in guinea pig cerebral cortexInhibitory activity against Tritiated [3H]- mepyramine binding to histamine H1 receptor in guinea pig cerebral cortex	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1021/jm00121a022
		DB00342	3779	74	None	-3	13	Guinea pig	6.5	pIC50	=	6.5	Binding	Inhibitory activity against Tritiated [3H]- mepyramine binding to histamine H1 receptor in guinea pig cerebral cortexInhibitory activity against Tritiated [3H]- mepyramine binding to histamine H1 receptor in guinea pig cerebral cortex	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1021/jm00121a022
		10141470	123557	0	None	-	0	Guinea pig	6.5	pIC50	=	6.5	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	494	8	1	5	6.4	O=C(O)c1ccccc1OCCN1CCC(c2cn(Cc3ccc(Cl)s3)c3ccccc23)CC1	10.1016/j.bmcl.2004.12.008
		CHEMBL361805	123557	0	None	-	0	Guinea pig	6.5	pIC50	=	6.5	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	494	8	1	5	6.4	O=C(O)c1ccccc1OCCN1CCC(c2cn(Cc3ccc(Cl)s3)c3ccccc23)CC1	10.1016/j.bmcl.2004.12.008
		153996	112668	2	None	-	3	Human	8.5	pIC50	=	8.5	Binding	Inhibitory concentration against histamine H1 receptorInhibitory concentration against histamine H1 receptor	ChEMBL	639	10	1	6	5.7	COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1021/jm058225d
		CHEMBL330366	112668	2	None	-	3	Human	8.5	pIC50	=	8.5	Binding	Inhibitory concentration against histamine H1 receptorInhibitory concentration against histamine H1 receptor	ChEMBL	639	10	1	6	5.7	COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1021/jm058225d
		CHEMBL539021	112668	2	None	-	3	Human	8.5	pIC50	=	8.5	Binding	Inhibitory concentration against histamine H1 receptorInhibitory concentration against histamine H1 receptor	ChEMBL	639	10	1	6	5.7	COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1021/jm058225d
		19426644	107174	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Binding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligandBinding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligand	ChEMBL	320	2	0	3	3.9	c1ccc2c(c1)Cc1ccccc1N1OC(CN3CCCC3)CC21	10.1016/s0960-894x(01)00721-1
		CHEMBL316438	107174	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Binding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligandBinding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligand	ChEMBL	320	2	0	3	3.9	c1ccc2c(c1)Cc1ccccc1N1OC(CN3CCCC3)CC21	10.1016/s0960-894x(01)00721-1
		1201549	597	24	None	-1	20	Human	8.5	pIC50	=	8.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		333	597	24	None	-1	20	Human	8.5	pIC50	=	8.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		7601	597	24	None	-1	20	Human	8.5	pIC50	=	8.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		CHEMBL1201203	597	24	None	-1	20	Human	8.5	pIC50	=	8.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		CHEMBL438151	597	24	None	-1	20	Human	8.5	pIC50	=	8.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		DB00245	597	24	None	-1	20	Human	8.5	pIC50	=	8.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		1227	2489	43	None	-2	12	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells after 3 hrsDisplacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells after 3 hrs	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmcl.2013.01.025
		2331	2489	43	None	-2	12	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells after 3 hrsDisplacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells after 3 hrs	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmcl.2013.01.025
		3957	2489	43	None	-2	12	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells after 3 hrsDisplacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells after 3 hrs	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmcl.2013.01.025
		4992	2489	43	None	-2	12	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells after 3 hrsDisplacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells after 3 hrs	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmcl.2013.01.025
		CHEMBL511	2489	43	None	-2	12	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells after 3 hrsDisplacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells after 3 hrs	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmcl.2013.01.025
		DB06691	2489	43	None	-2	12	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells after 3 hrsDisplacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells after 3 hrs	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmcl.2013.01.025
		45269436	196656	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	422	5	0	5	4.3	CN(C1CCOCC1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1	10.1016/j.bmcl.2009.05.086
		CHEMBL564446	196656	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	422	5	0	5	4.3	CN(C1CCOCC1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1	10.1016/j.bmcl.2009.05.086
		135	2532	43	None	-1	58	Human	8.5	pIC50	=	8.5	Binding	Binding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligandBinding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligand	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(01)00721-1
		1796	2532	43	None	-1	58	Human	8.5	pIC50	=	8.5	Binding	Binding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligandBinding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligand	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(01)00721-1
		4184	2532	43	None	-1	58	Human	8.5	pIC50	=	8.5	Binding	Binding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligandBinding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligand	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(01)00721-1
		CHEMBL6437	2532	43	None	-1	58	Human	8.5	pIC50	=	8.5	Binding	Binding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligandBinding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligand	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(01)00721-1
		DB06148	2532	43	None	-1	58	Human	8.5	pIC50	=	8.5	Binding	Binding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligandBinding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligand	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(01)00721-1
		2284	3182	33	None	1	29	Human	8.5	pIC50	=	8.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		4926	3182	33	None	1	29	Human	8.5	pIC50	=	8.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		7281	3182	33	None	1	29	Human	8.5	pIC50	=	8.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		CHEMBL564	3182	33	None	1	29	Human	8.5	pIC50	=	8.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		DB00420	3182	33	None	1	29	Human	8.5	pIC50	=	8.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		11539632	70561	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Inhibitory concentration against histamine H1 receptorInhibitory concentration against histamine H1 receptor	ChEMBL	447	8	1	5	4.8	Cc1cc(OCCN(C)C)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12	10.1021/jm050103y
		CHEMBL194837	70561	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Inhibitory concentration against histamine H1 receptorInhibitory concentration against histamine H1 receptor	ChEMBL	447	8	1	5	4.8	Cc1cc(OCCN(C)C)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12	10.1021/jm050103y
		155568607	176112	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	490	6	1	5	5.2	COc1ccccc1OC[C@H](O)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/j.bmcl.2019.126712
		CHEMBL4591702	176112	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	490	6	1	5	5.2	COc1ccccc1OC[C@H](O)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/j.bmcl.2019.126712
		277	1301	62	None	-2	50	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		2913	1301	62	None	-2	50	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		765	1301	62	None	-2	50	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		CHEMBL516	1301	62	None	-2	50	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		DB00434	1301	62	None	-2	50	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		1227	2489	43	None	-2	12	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		2331	2489	43	None	-2	12	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		3957	2489	43	None	-2	12	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		4992	2489	43	None	-2	12	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		CHEMBL511	2489	43	None	-2	12	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		DB06691	2489	43	None	-2	12	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		44319133	106941	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.	ChEMBL	312	2	0	3	3.5	CN(C)CC1CC2c3cc(F)ccc3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
		CHEMBL314885	106941	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.	ChEMBL	312	2	0	3	3.5	CN(C)CC1CC2c3cc(F)ccc3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
		10103	3416	72	None	25	3	Human	8.4	pIC50	=	8.4	Binding	Inhibitory concentration against histamine H1 receptorInhibitory concentration against histamine H1 receptor	ChEMBL	415	2	0	3	5.6	Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1021/jm058225d
		133017	3416	72	None	25	3	Human	8.4	pIC50	=	8.4	Binding	Inhibitory concentration against histamine H1 receptorInhibitory concentration against histamine H1 receptor	ChEMBL	415	2	0	3	5.6	Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1021/jm058225d
		2413	3416	72	None	25	3	Human	8.4	pIC50	=	8.4	Binding	Inhibitory concentration against histamine H1 receptorInhibitory concentration against histamine H1 receptor	ChEMBL	415	2	0	3	5.6	Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1021/jm058225d
		CHEMBL91397	3416	72	None	25	3	Human	8.4	pIC50	=	8.4	Binding	Inhibitory concentration against histamine H1 receptorInhibitory concentration against histamine H1 receptor	ChEMBL	415	2	0	3	5.6	Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1021/jm058225d
		DB11614	3416	72	None	25	3	Human	8.4	pIC50	=	8.4	Binding	Inhibitory concentration against histamine H1 receptorInhibitory concentration against histamine H1 receptor	ChEMBL	415	2	0	3	5.6	Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1021/jm058225d
		13726485	91424	1	None	-	0	Guinea pig	7.5	pIC50	=	7.5	Binding	Inhibition of [3H]mepyramine binding to the histamine receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the histamine receptor in guinea pig cortex	ChEMBL	265	3	0	4	1.4	CN(C)CC[C@@H]1CN(C)C(=S)c2cccnc2O1	10.1021/jm00108a012
		CHEMBL24031	91424	1	None	-	0	Guinea pig	7.5	pIC50	=	7.5	Binding	Inhibition of [3H]mepyramine binding to the histamine receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the histamine receptor in guinea pig cortex	ChEMBL	265	3	0	4	1.4	CN(C)CC[C@@H]1CN(C)C(=S)c2cccnc2O1	10.1021/jm00108a012
		11247290	136703	0	None	-	0	Guinea pig	6.5	pIC50	=	6.5	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	424	8	1	4	4.9	CCOCCn1cc(C2CCN(Cc3ccc(F)c(C(=O)O)c3)CC2)c2ccccc21	10.1021/jm0498203
		CHEMBL374059	136703	0	None	-	0	Guinea pig	6.5	pIC50	=	6.5	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	424	8	1	4	4.9	CCOCCn1cc(C2CCN(Cc3ccc(F)c(C(=O)O)c3)CC2)c2ccccc21	10.1021/jm0498203
		9918576	207337	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibitory concentration against histamine H1 receptorInhibitory concentration against histamine H1 receptor	ChEMBL	764	14	0	10	7.0	COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC	10.1021/jm058225d
		CHEMBL93556	207337	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibitory concentration against histamine H1 receptorInhibitory concentration against histamine H1 receptor	ChEMBL	764	14	0	10	7.0	COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC	10.1021/jm058225d
		10420190	206760	0	None	-	3	Human	5.5	pIC50	=	5.5	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	195	8	2	2	2.3	NCCCCCCCCc1c[nH]cn1	10.1021/jm030936t
		CHEMBL90063	206760	0	None	-	3	Human	5.5	pIC50	=	5.5	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	195	8	2	2	2.3	NCCCCCCCCc1c[nH]cn1	10.1021/jm030936t
		10660	14416	58	None	2	12	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
		CHEMBL1200406	14416	58	None	2	12	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
		2771	195017	74	None	-2	27	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	nan
		CHEMBL1200781	195017	74	None	-2	27	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	nan
		CHEMBL549	195017	74	None	-2	27	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	nan
		11259138	85012	0	None	-	0	Guinea pig	6.5	pIC50	=	6.5	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	436	10	1	5	4.5	CCOCCn1cc(C2CCN(Cc3ccc(OCC(=O)O)cc3)CC2)c2ccccc21	10.1021/jm0498203
		CHEMBL223882	85012	0	None	-	0	Guinea pig	6.5	pIC50	=	6.5	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	436	10	1	5	4.5	CCOCCn1cc(C2CCN(Cc3ccc(OCC(=O)O)cc3)CC2)c2ccccc21	10.1021/jm0498203
		45272487	196402	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	547	7	1	9	3.4	Cn1c(N2CCCN(CCCN3c4ccccc4Sc4ccc(/C=C\C(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmcl.2009.03.124
		CHEMBL562792	196402	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	547	7	1	9	3.4	Cn1c(N2CCCN(CCCN3c4ccccc4Sc4ccc(/C=C\C(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmcl.2009.03.124
		54582402	62008	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	502	5	1	8	2.3	Cn1c(N2CCN(CC/C=C3/c4ccccc4COc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmc.2011.03.003
		CHEMBL1774503	62008	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	502	5	1	8	2.3	Cn1c(N2CCN(CC/C=C3/c4ccccc4COc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmc.2011.03.003
		11211919	84753	0	None	-	0	Guinea pig	6.5	pIC50	=	6.5	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	406	8	1	4	4.8	CCOCCn1cc(C2CCN(Cc3ccccc3C(=O)O)CC2)c2ccccc21	10.1021/jm0498203
		CHEMBL222984	84753	0	None	-	0	Guinea pig	6.5	pIC50	=	6.5	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	406	8	1	4	4.8	CCOCCn1cc(C2CCN(Cc3ccccc3C(=O)O)CC2)c2ccccc21	10.1021/jm0498203
		10205121	66692	0	None	-	0	Guinea pig	6.5	pIC50	=	6.5	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	464	6	1	4	6.5	O=C(O)c1cccc(CN2CCC(c3cn(Cc4ccc(Cl)s4)c4ccccc34)CC2)c1	10.1016/j.bmcl.2004.12.008
		CHEMBL185489	66692	0	None	-	0	Guinea pig	6.5	pIC50	=	6.5	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	464	6	1	4	6.5	O=C(O)c1cccc(CN2CCC(c3cn(Cc4ccc(Cl)s4)c4ccccc34)CC2)c1	10.1016/j.bmcl.2004.12.008
		11340290	64364	0	None	-	0	Guinea pig	7.5	pIC50	=	7.5	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	466	11	1	6	4.6	CCOCCn1cc(C2CCN(CCOc3cc(OC)ccc3C(=O)O)CC2)c2ccccc21	10.1021/jm0498203
		CHEMBL181278	64364	0	None	-	0	Guinea pig	7.5	pIC50	=	7.5	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	466	11	1	6	4.6	CCOCCn1cc(C2CCN(CCOc3cc(OC)ccc3C(=O)O)CC2)c2ccccc21	10.1021/jm0498203
		14762564	4311	2	None	-	0	Guinea pig	6.5	pIC50	=	6.5	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	449	6	1	3	2.8	O=C(NCCN1CCN(Cc2ccccc2)CC1)c1ccccc1I	10.1021/jm00173a011
		CHEMBL100858	4311	2	None	-	0	Guinea pig	6.5	pIC50	=	6.5	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	449	6	1	3	2.8	O=C(NCCN1CCN(Cc2ccccc2)CC1)c1ccccc1I	10.1021/jm00173a011
		11363750	84630	0	None	-	0	Guinea pig	6.5	pIC50	=	6.5	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	484	8	1	4	5.5	CCOCCn1cc(C2CCN(Cc3cc(C(=O)O)ccc3Br)CC2)c2ccccc21	10.1021/jm0498203
		CHEMBL222214	84630	0	None	-	0	Guinea pig	6.5	pIC50	=	6.5	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	484	8	1	4	5.5	CCOCCn1cc(C2CCN(Cc3cc(C(=O)O)ccc3Br)CC2)c2ccccc21	10.1021/jm0498203
		45270753	195400	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	521	7	1	9	3.0	Cn1c(N2CCN(CCCCN3c4ccccc4Sc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmcl.2009.03.124
		CHEMBL552057	195400	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	521	7	1	9	3.0	Cn1c(N2CCN(CCCCN3c4ccccc4Sc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmcl.2009.03.124
		11659592	8143	0	None	-	1	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	310	5	0	3	4.6	C[C@H](c1cccnc1)c1c(CCN(C)C)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		CHEMBL1091777	8143	0	None	-	1	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	310	5	0	3	4.6	C[C@H](c1cccnc1)c1c(CCN(C)C)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		10161929	137187	0	None	-	0	Guinea pig	6.5	pIC50	=	6.5	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	464	9	1	6	4.4	O=C(O)c1ccccc1OCCN1CCC(c2cn(CCC3OCCO3)c3ccccc23)CC1	10.1021/jm0498203
		CHEMBL374869	137187	0	None	-	0	Guinea pig	6.5	pIC50	=	6.5	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	464	9	1	6	4.4	O=C(O)c1ccccc1OCCN1CCC(c2cn(CCC3OCCO3)c3ccccc23)CC1	10.1021/jm0498203
		149227688	174629	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	544	6	1	5	6.1	OC(COc1ccccc1OC(F)(F)F)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/j.bmcl.2019.126712
		CHEMBL4557928	174629	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	544	6	1	5	6.1	OC(COc1ccccc1OC(F)(F)F)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/j.bmcl.2019.126712
		44566054	187141	2	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]pyrilamine from human histamine receptor subtype 1 expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine receptor subtype 1 expressed in CHO cells	ChEMBL	350	9	0	3	5.1	CCN(CC)CCCCCCn1c2ccccc2c(=O)c2ccccc21	10.1128/aac.00669-07
		CHEMBL491889	187141	2	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]pyrilamine from human histamine receptor subtype 1 expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine receptor subtype 1 expressed in CHO cells	ChEMBL	350	9	0	3	5.1	CCN(CC)CCCCCCn1c2ccccc2c(=O)c2ccccc21	10.1128/aac.00669-07
		213	3853	55	None	-8	44	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		2717	3853	55	None	-8	44	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		5533	3853	55	None	-8	44	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		CHEMBL621	3853	55	None	-8	44	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		DB00656	3853	55	None	-8	44	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		44332061	4415	0	None	-	0	Guinea pig	6.4	pIC50	=	6.4	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	257	1	1	3	1.8	CON1CCN2Cc3[nH]c4ccccc4c3CC2C1	10.1021/jm00173a011
		CHEMBL101490	4415	0	None	-	0	Guinea pig	6.4	pIC50	=	6.4	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	257	1	1	3	1.8	CON1CCN2Cc3[nH]c4ccccc4c3CC2C1	10.1021/jm00173a011
		44392588	66653	0	None	-	0	Guinea pig	6.4	pIC50	=	6.4	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	494	7	1	5	6.5	COc1ccc(CN2CCC(c3cn(Cc4ccc(Cl)s4)c4ccccc34)CC2)cc1C(=O)O	10.1016/j.bmcl.2004.12.008
		CHEMBL185289	66653	0	None	-	0	Guinea pig	6.4	pIC50	=	6.4	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	494	7	1	5	6.5	COc1ccc(CN2CCC(c3cn(Cc4ccc(Cl)s4)c4ccccc34)CC2)cc1C(=O)O	10.1016/j.bmcl.2004.12.008
		10139592	85004	0	None	-	0	Guinea pig	7.4	pIC50	=	7.4	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	462	8	1	5	5.4	O=C(O)c1ccccc1OCCN1CCC(c2cn(Cc3ccco3)c3cc(F)ccc23)CC1	10.1021/jm0498203
		CHEMBL223837	85004	0	None	-	0	Guinea pig	7.4	pIC50	=	7.4	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	462	8	1	5	5.4	O=C(O)c1ccccc1OCCN1CCC(c2cn(Cc3ccco3)c3cc(F)ccc23)CC1	10.1021/jm0498203
		45270750	195305	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	507	6	1	9	2.6	Cn1c(N2CCN(CCCN3c4ccccc4Sc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmcl.2009.03.124
		CHEMBL551457	195305	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	507	6	1	9	2.6	Cn1c(N2CCN(CCCN3c4ccccc4Sc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmcl.2009.03.124
		44319098	205785	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.	ChEMBL	362	2	0	3	4.4	CN(C)CC1CC2c3cccc(C(F)(F)F)c3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
		CHEMBL83073	205785	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.	ChEMBL	362	2	0	3	4.4	CN(C)CC1CC2c3cccc(C(F)(F)F)c3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
		44332031	208113	0	None	-	0	Guinea pig	6.4	pIC50	=	6.4	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	272	1	1	3	1.4	O=[N+]([O-])N1CCN2Cc3[nH]c4ccccc4c3CC2C1	10.1021/jm00173a011
		CHEMBL97938	208113	0	None	-	0	Guinea pig	6.4	pIC50	=	6.4	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	272	1	1	3	1.4	O=[N+]([O-])N1CCN2Cc3[nH]c4ccccc4c3CC2C1	10.1021/jm00173a011
		6726	1280	51	None	3	13	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		7151	1280	51	None	3	13	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		749	1280	51	None	3	13	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		CHEMBL648	1280	51	None	3	13	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		DB01176	1280	51	None	3	13	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		2337	3256	77	None	1	62	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		50	3256	77	None	1	62	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		5002	3256	77	None	1	62	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		CHEMBL716	3256	77	None	1	62	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		DB01224	3256	77	None	1	62	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		2762	3863	31	None	-9	2	Human	7.4	pIC50	=	7.4	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1021/jm030936t
		5587	3863	31	None	-9	2	Human	7.4	pIC50	=	7.4	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1021/jm030936t
		7318	3863	31	None	-9	2	Human	7.4	pIC50	=	7.4	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1021/jm030936t
		CHEMBL1241	3863	31	None	-9	2	Human	7.4	pIC50	=	7.4	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1021/jm030936t
		DB00792	3863	31	None	-9	2	Human	7.4	pIC50	=	7.4	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1021/jm030936t
		10140544	141639	0	None	-	0	Guinea pig	6.4	pIC50	=	6.4	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	478	9	1	6	4.4	O=C(O)c1ccccc1OCCN1CCC(c2cn(CCC3COCCO3)c3ccccc23)CC1	10.1021/jm0498203
		CHEMBL385311	141639	0	None	-	0	Guinea pig	6.4	pIC50	=	6.4	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	478	9	1	6	4.4	O=C(O)c1ccccc1OCCN1CCC(c2cn(CCC3COCCO3)c3ccccc23)CC1	10.1021/jm0498203
		23027211	197250	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptorDisplacement of [3H]pyrilamine from human histamine H1 receptor	ChEMBL	421	5	2	5	4.3	Cc1cc(N(C)C)nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)c(Cl)c3)CC2)n1	10.1016/j.bmcl.2009.09.003
		CHEMBL568400	197250	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptorDisplacement of [3H]pyrilamine from human histamine H1 receptor	ChEMBL	421	5	2	5	4.3	Cc1cc(N(C)C)nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)c(Cl)c3)CC2)n1	10.1016/j.bmcl.2009.09.003
		11231249	50338	1	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	277	11	1	2	4.2	c1nc(CCCCCCCCCCN2CCCC2)c[nH]1	10.1021/jm030936t
		CHEMBL157217	50338	1	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	277	11	1	2	4.2	c1nc(CCCCCCCCCCN2CCCC2)c[nH]1	10.1021/jm030936t
		10264715	50398	1	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	262	12	1	2	4.5	NCCCCCCCCCCCCc1ccncc1	10.1021/jm030936t
		CHEMBL157273	50398	1	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	262	12	1	2	4.5	NCCCCCCCCCCCCc1ccncc1	10.1021/jm030936t
		11358657	44834	1	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	305	13	1	2	4.9	c1nc(CCCCCCCCCCCCN2CCCC2)c[nH]1	10.1021/jm030936t
		CHEMBL152221	44834	1	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	305	13	1	2	4.9	c1nc(CCCCCCCCCCCCN2CCCC2)c[nH]1	10.1021/jm030936t
		45270350	195074	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	434	6	0	4	5.7	CN(CC1CCCCC1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1	10.1016/j.bmcl.2009.05.086
		CHEMBL549598	195074	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	434	6	0	4	5.7	CN(CC1CCCCC1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1	10.1016/j.bmcl.2009.05.086
		155532375	171780	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	490	6	1	5	5.2	COc1ccccc1OC[C@@H](O)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/j.bmcl.2019.126712
		CHEMBL4467816	171780	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	490	6	1	5	5.2	COc1ccccc1OC[C@@H](O)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/j.bmcl.2019.126712
		155557098	174569	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	478	5	1	4	5.3	OC(COc1ccccc1F)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/j.bmcl.2019.126712
		CHEMBL4556553	174569	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	478	5	1	4	5.3	OC(COc1ccccc1F)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/j.bmcl.2019.126712
		180	401	56	None	-1	40	Human	8.3	pIC50	=	8.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		200	401	56	None	-1	40	Human	8.3	pIC50	=	8.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		2160	401	56	None	-1	40	Human	8.3	pIC50	=	8.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		CHEMBL629	401	56	None	-1	40	Human	8.3	pIC50	=	8.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		DB00321	401	56	None	-1	40	Human	8.3	pIC50	=	8.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		135398737	958	93	None	2	89	Human	8.3	pIC50	=	8.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		38	958	93	None	2	89	Human	8.3	pIC50	=	8.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		722	958	93	None	2	89	Human	8.3	pIC50	=	8.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		CHEMBL42	958	93	None	2	89	Human	8.3	pIC50	=	8.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		DB00363	958	93	None	2	89	Human	8.3	pIC50	=	8.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		11753159	547	6	None	-1	2	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	525	5	1	5	4.7	Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl	10.1021/jm300682j
		7679	547	6	None	-1	2	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	525	5	1	5	4.7	Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl	10.1021/jm300682j
		CHEMBL2158814	547	6	None	-1	2	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	525	5	1	5	4.7	Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl	10.1021/jm300682j
		1212	1662	50	None	-41	65	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		204	1662	50	None	-41	65	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		3372	1662	50	None	-41	65	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		CHEMBL726	1662	50	None	-41	65	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		DB00623	1662	50	None	-41	65	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		2337	3256	77	None	-1	62	Rat	7.4	pIC50	=	7.4	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1073/pnas.0611417104
		50	3256	77	None	-1	62	Rat	7.4	pIC50	=	7.4	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1073/pnas.0611417104
		5002	3256	77	None	-1	62	Rat	7.4	pIC50	=	7.4	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1073/pnas.0611417104
		CHEMBL716	3256	77	None	-1	62	Rat	7.4	pIC50	=	7.4	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1073/pnas.0611417104
		DB01224	3256	77	None	-1	62	Rat	7.4	pIC50	=	7.4	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1073/pnas.0611417104
		44189144	195965	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	521	7	1	9	2.5	Cn1c(N2CCN(CCCN3c4ccccc4Sc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmc.2011.03.003
		CHEMBL559664	195965	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	521	7	1	9	2.5	Cn1c(N2CCN(CCCN3c4ccccc4Sc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmc.2011.03.003
		44189144	195965	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	521	7	1	9	2.5	Cn1c(N2CCN(CCCN3c4ccccc4Sc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmcl.2009.03.124
		CHEMBL559664	195965	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	521	7	1	9	2.5	Cn1c(N2CCN(CCCN3c4ccccc4Sc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmcl.2009.03.124
		155526952	171176	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	538	5	1	4	5.9	OC(COc1ccccc1Br)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/j.bmcl.2019.126712
		CHEMBL4458953	171176	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	538	5	1	4	5.9	OC(COc1ccccc1Br)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/j.bmcl.2019.126712
		9822631	122959	0	None	-	0	Guinea pig	6.4	pIC50	=	6.4	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	406	8	1	4	4.8	CCOCCn1cc(C2CCN(Cc3cccc(C(=O)O)c3)CC2)c2ccccc21	10.1016/j.bmcl.2004.12.008
		CHEMBL360791	122959	0	None	-	0	Guinea pig	6.4	pIC50	=	6.4	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	406	8	1	4	4.8	CCOCCn1cc(C2CCN(Cc3cccc(C(=O)O)c3)CC2)c2ccccc21	10.1016/j.bmcl.2004.12.008
		16722760	61996	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	519	6	1	9	2.4	Cn1c(N2CCCN(CCCN3c4ccccc4COc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmc.2011.03.003
		CHEMBL1774491	61996	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	519	6	1	9	2.4	Cn1c(N2CCCN(CCCN3c4ccccc4COc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmc.2011.03.003
		45269933	195295	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	518	7	1	8	3.5	Cn1c(C2=CCN(CCCN3c4ccccc4Sc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmcl.2009.03.124
		CHEMBL551394	195295	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	518	7	1	8	3.5	Cn1c(C2=CCN(CCCN3c4ccccc4Sc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmcl.2009.03.124
		45268186	196530	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	563	8	1	9	3.9	CCC(C(=O)O)c1ccc2c(c1)N(CCCN1CCCN(c3cc(=O)n(C)c(=O)n3C)CC1)c1ccccc1S2	10.1016/j.bmcl.2009.03.124
		CHEMBL563647	196530	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	563	8	1	9	3.9	CCC(C(=O)O)c1ccc2c(c1)N(CCCN1CCCN(c3cc(=O)n(C)c(=O)n3C)CC1)c1ccccc1S2	10.1016/j.bmcl.2009.03.124
		133	2496	52	None	-102	42	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		1723	2496	52	None	-102	42	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		28693	2496	52	None	-102	42	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		CHEMBL19215	2496	52	None	-102	42	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		DB13520	2496	52	None	-102	42	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		155544367	173374	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at human Gq-coupled HRH1 expressed in CHOK1 cells assessed as inhibition in Orexin A-induced beta-arrestin 2 recruitment incubated for 30 mins followed by Orexin A addition and measured after 90 or 180 mins by pathhunter beta-arrestin assayAntagonist activity at human Gq-coupled HRH1 expressed in CHOK1 cells assessed as inhibition in Orexin A-induced beta-arrestin 2 recruitment incubated for 30 mins followed by Orexin A addition and measured after 90 or 180 mins by pathhunter beta-arrestin assay	ChEMBL	508	3	0	4	6.0	CC[C@]12CCCN(C(=O)c3cccc(Br)c3)CCc3c(n(c4ccccc34)C(=O)C1)[C@@H]2OC	10.1021/acs.jmedchem.9b01924
		CHEMBL4527708	173374	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at human Gq-coupled HRH1 expressed in CHOK1 cells assessed as inhibition in Orexin A-induced beta-arrestin 2 recruitment incubated for 30 mins followed by Orexin A addition and measured after 90 or 180 mins by pathhunter beta-arrestin assayAntagonist activity at human Gq-coupled HRH1 expressed in CHOK1 cells assessed as inhibition in Orexin A-induced beta-arrestin 2 recruitment incubated for 30 mins followed by Orexin A addition and measured after 90 or 180 mins by pathhunter beta-arrestin assay	ChEMBL	508	3	0	4	6.0	CC[C@]12CCCN(C(=O)c3cccc(Br)c3)CCc3c(n(c4ccccc34)C(=O)C1)[C@@H]2OC	10.1021/acs.jmedchem.9b01924
		11385692	137049	0	None	-	0	Guinea pig	7.4	pIC50	=	7.4	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	462	8	1	5	5.4	O=C(O)c1ccccc1OCCN1CCC(c2cn(Cc3ccoc3)c3cc(F)ccc23)CC1	10.1021/jm0498203
		CHEMBL374675	137049	0	None	-	0	Guinea pig	7.4	pIC50	=	7.4	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	462	8	1	5	5.4	O=C(O)c1ccccc1OCCN1CCC(c2cn(Cc3ccoc3)c3cc(F)ccc23)CC1	10.1021/jm0498203
		14407121	60085	0	None	-	0	Guinea pig	7.4	pIC50	=	7.4	Binding	Inhibitory activity against Tritiated [3H]- mepyramine binding to histamine H1 receptor in guinea pig cerebral cortexInhibitory activity against Tritiated [3H]- mepyramine binding to histamine H1 receptor in guinea pig cerebral cortex	ChEMBL	473	10	1	5	5.3	COc1cc(C(C)=O)ccc1OCCCN1CCC(C(O)(c2ccccc2)c2ccccc2)CC1	10.1021/jm00121a022
		CHEMBL17390	60085	0	None	-	0	Guinea pig	7.4	pIC50	=	7.4	Binding	Inhibitory activity against Tritiated [3H]- mepyramine binding to histamine H1 receptor in guinea pig cerebral cortexInhibitory activity against Tritiated [3H]- mepyramine binding to histamine H1 receptor in guinea pig cerebral cortex	ChEMBL	473	10	1	5	5.3	COc1cc(C(C)=O)ccc1OCCCN1CCC(C(O)(c2ccccc2)c2ccccc2)CC1	10.1021/jm00121a022
		242	470	124	None	-22	51	Human	6.4	pIC50	=	6.4	Binding	Antagonistic activity at histamine1 receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at histamine1 receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2016.04.087
		34	470	124	None	-22	51	Human	6.4	pIC50	=	6.4	Binding	Antagonistic activity at histamine1 receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at histamine1 receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2016.04.087
		60795	470	124	None	-22	51	Human	6.4	pIC50	=	6.4	Binding	Antagonistic activity at histamine1 receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at histamine1 receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2016.04.087
		CHEMBL1112	470	124	None	-22	51	Human	6.4	pIC50	=	6.4	Binding	Antagonistic activity at histamine1 receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at histamine1 receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2016.04.087
		DB01238	470	124	None	-22	51	Human	6.4	pIC50	=	6.4	Binding	Antagonistic activity at histamine1 receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at histamine1 receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2016.04.087
		14762566	107735	7	None	-	0	Guinea pig	6.4	pIC50	=	6.4	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	401	6	1	3	3.0	O=C(NCCN1CCN(Cc2ccccc2)CC1)c1ccccc1Br	10.1021/jm00173a011
		CHEMBL319123	107735	7	None	-	0	Guinea pig	6.4	pIC50	=	6.4	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	401	6	1	3	3.0	O=C(NCCN1CCN(Cc2ccccc2)CC1)c1ccccc1Br	10.1021/jm00173a011
		14842830	98986	0	None	-	0	Guinea pig	6.4	pIC50	=	6.4	Binding	Inhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortex	ChEMBL	308	5	0	2	4.5	CN(C)CCC(c1ccc(Cl)cc1)c1ccc(Cl)cn1	10.1021/jm00108a012
		CHEMBL279907	98986	0	None	-	0	Guinea pig	6.4	pIC50	=	6.4	Binding	Inhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortex	ChEMBL	308	5	0	2	4.5	CN(C)CCC(c1ccc(Cl)cc1)c1ccc(Cl)cn1	10.1021/jm00108a012
		15181802	12165	0	None	-	0	Guinea pig	7.4	pIC50	=	7.4	Binding	Compound is evaluated for in vitro receptor binding affinity against H1 receptorCompound is evaluated for in vitro receptor binding affinity against H1 receptor	ChEMBL	471	7	0	7	3.4	Cn1c(=O)c2c(ncn2CCCN2CCC(C(c3ccccc3)c3ccccc3)CC2)n(C)c1=O	10.1021/jm00020a018
		CHEMBL1184199	12165	0	None	-	0	Guinea pig	7.4	pIC50	=	7.4	Binding	Compound is evaluated for in vitro receptor binding affinity against H1 receptorCompound is evaluated for in vitro receptor binding affinity against H1 receptor	ChEMBL	471	7	0	7	3.4	Cn1c(=O)c2c(ncn2CCCN2CCC(C(c3ccccc3)c3ccccc3)CC2)n(C)c1=O	10.1021/jm00020a018
		CHEMBL338611	12165	0	None	-	0	Guinea pig	7.4	pIC50	=	7.4	Binding	Compound is evaluated for in vitro receptor binding affinity against H1 receptorCompound is evaluated for in vitro receptor binding affinity against H1 receptor	ChEMBL	471	7	0	7	3.4	Cn1c(=O)c2c(ncn2CCCN2CCC(C(c3ccccc3)c3ccccc3)CC2)n(C)c1=O	10.1021/jm00020a018
		3191	102858	97	None	-	25	Guinea pig	7.4	pIC50	=	7.4	Binding	Compound is evaluated for in vitro receptor binding affinity against H1 receptorCompound is evaluated for in vitro receptor binding affinity against H1 receptor	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	10.1021/jm00020a018
		CHEMBL305660	102858	97	None	-	25	Guinea pig	7.4	pIC50	=	7.4	Binding	Compound is evaluated for in vitro receptor binding affinity against H1 receptorCompound is evaluated for in vitro receptor binding affinity against H1 receptor	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	10.1021/jm00020a018
		3168	9262	92	None	-87	21	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	nan
		CHEMBL1108	9262	92	None	-87	21	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	nan
		11005810	10466	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	517	10	1	4	6.2	N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
		CHEMBL116463	10466	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	517	10	1	4	6.2	N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
		45269062	196512	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	535	8	2	9	3.6	Cn1c(NCCCN2CCC(CN3c4ccccc4Sc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmcl.2009.03.124
		CHEMBL563520	196512	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	535	8	2	9	3.6	Cn1c(NCCCN2CCC(CN3c4ccccc4Sc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmcl.2009.03.124
		9954899	204463	17	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligandBinding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligand	ChEMBL	440	2	1	7	3.3	CN1CCN(C2=Nc3ccccc3Nc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1	10.1021/jm991005d
		CHEMBL72292	204463	17	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligandBinding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligand	ChEMBL	440	2	1	7	3.3	CN1CCN(C2=Nc3ccccc3Nc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1	10.1021/jm991005d
		11189839	84334	0	None	-	0	Guinea pig	7.3	pIC50	=	7.3	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	438	9	1	4	5.5	CCCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2ccc(F)cc21	10.1021/jm0498203
		CHEMBL221664	84334	0	None	-	0	Guinea pig	7.3	pIC50	=	7.3	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	438	9	1	4	5.5	CCCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2ccc(F)cc21	10.1021/jm0498203
		9954899	204463	17	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inhibitory binding of [3H]mepyramine to histamine H1 receptors in rat brain membranesInhibitory binding of [3H]mepyramine to histamine H1 receptors in rat brain membranes	ChEMBL	440	2	1	7	3.3	CN1CCN(C2=Nc3ccccc3Nc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1	10.1021/jm9704457
		CHEMBL72292	204463	17	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inhibitory binding of [3H]mepyramine to histamine H1 receptors in rat brain membranesInhibitory binding of [3H]mepyramine to histamine H1 receptors in rat brain membranes	ChEMBL	440	2	1	7	3.3	CN1CCN(C2=Nc3ccccc3Nc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1	10.1021/jm9704457
		44319134	205993	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.	ChEMBL	362	2	0	3	4.4	CN(C)CC1CC2c3c(cccc3C(F)(F)F)Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
		CHEMBL84810	205993	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.	ChEMBL	362	2	0	3	4.4	CN(C)CC1CC2c3c(cccc3C(F)(F)F)Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
		9979651	84762	0	None	-	0	Guinea pig	6.3	pIC50	=	6.3	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	422	8	1	5	4.4	COCCn1cc(C2CCN(Cc3ccc(OC)c(C(=O)O)c3)CC2)c2ccccc21	10.1021/jm0498203
		CHEMBL223025	84762	0	None	-	0	Guinea pig	6.3	pIC50	=	6.3	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	422	8	1	5	4.4	COCCn1cc(C2CCN(Cc3ccc(OC)c(C(=O)O)c3)CC2)c2ccccc21	10.1021/jm0498203
		10409896	65577	0	None	-	0	Guinea pig	6.3	pIC50	=	6.3	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	420	8	1	4	5.5	CCCCn1cc(C2CCN(Cc3ccc(OC)c(C(=O)O)c3)CC2)c2ccccc21	10.1016/j.bmcl.2004.12.008
		CHEMBL183169	65577	0	None	-	0	Guinea pig	6.3	pIC50	=	6.3	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	420	8	1	4	5.5	CCCCn1cc(C2CCN(Cc3ccc(OC)c(C(=O)O)c3)CC2)c2ccccc21	10.1016/j.bmcl.2004.12.008
		14762590	4489	1	None	-	0	Guinea pig	6.3	pIC50	=	6.3	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	350	7	1	2	4.5	CCc1ccccc1NC(=O)CCN1CCC(Cc2ccccc2)CC1	10.1021/jm00173a011
		CHEMBL101973	4489	1	None	-	0	Guinea pig	6.3	pIC50	=	6.3	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	350	7	1	2	4.5	CCc1ccccc1NC(=O)CCN1CCC(Cc2ccccc2)CC1	10.1021/jm00173a011
		11811722	10065	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	413	5	1	4	4.4	O=C1NCN(c2ccccc2)C12CCN(Cc1cccc(Oc3ccccc3)c1)CC2	10.1021/jm010878g
		CHEMBL115280	10065	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	413	5	1	4	4.4	O=C1NCN(c2ccccc2)C12CCN(Cc1cccc(Oc3ccccc3)c1)CC2	10.1021/jm010878g
		2286	3183	51	None	-2	30	Human	8.3	pIC50	=	8.3	Binding	Binding affinity to histamine H1 receptor (unknown origin) by radioligand binding assayBinding affinity to histamine H1 receptor (unknown origin) by radioligand binding assay	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1021/jm400856t
		4927	3183	51	None	-2	30	Human	8.3	pIC50	=	8.3	Binding	Binding affinity to histamine H1 receptor (unknown origin) by radioligand binding assayBinding affinity to histamine H1 receptor (unknown origin) by radioligand binding assay	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1021/jm400856t
		7282	3183	51	None	-2	30	Human	8.3	pIC50	=	8.3	Binding	Binding affinity to histamine H1 receptor (unknown origin) by radioligand binding assayBinding affinity to histamine H1 receptor (unknown origin) by radioligand binding assay	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1021/jm400856t
		CHEMBL643	3183	51	None	-2	30	Human	8.3	pIC50	=	8.3	Binding	Binding affinity to histamine H1 receptor (unknown origin) by radioligand binding assayBinding affinity to histamine H1 receptor (unknown origin) by radioligand binding assay	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1021/jm400856t
		DB01069	3183	51	None	-2	30	Human	8.3	pIC50	=	8.3	Binding	Binding affinity to histamine H1 receptor (unknown origin) by radioligand binding assayBinding affinity to histamine H1 receptor (unknown origin) by radioligand binding assay	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1021/jm400856t
		1227	2489	43	None	-5	12	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm300671m
		2331	2489	43	None	-5	12	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm300671m
		3957	2489	43	None	-5	12	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm300671m
		4992	2489	43	None	-5	12	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm300671m
		CHEMBL511	2489	43	None	-5	12	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm300671m
		DB06691	2489	43	None	-5	12	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm300671m
		44318842	206108	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.	ChEMBL	308	2	0	3	3.7	Cc1ccc2c(c1)N1OC(CN(C)C)CC1c1ccccc1C2	10.1016/s0960-894x(01)00721-1
		CHEMBL85735	206108	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.	ChEMBL	308	2	0	3	3.7	Cc1ccc2c(c1)N1OC(CN(C)C)CC1c1ccccc1C2	10.1016/s0960-894x(01)00721-1
		1971	2866	38	None	-1	30	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		2404	2866	38	None	-1	30	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		4543	2866	38	None	-1	30	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		CHEMBL445	2866	38	None	-1	30	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		DB00540	2866	38	None	-1	30	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		11247939	137105	0	None	-	0	Guinea pig	6.3	pIC50	=	6.3	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	450	10	1	5	4.9	CCOCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2cccc(C)c21	10.1021/jm0498203
		CHEMBL374754	137105	0	None	-	0	Guinea pig	6.3	pIC50	=	6.3	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	450	10	1	5	4.9	CCOCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2cccc(C)c21	10.1021/jm0498203
		11328514	137858	0	None	-	0	Guinea pig	6.3	pIC50	=	6.3	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	454	10	1	5	4.8	CCOCCn1cc(C2CCN(CCOc3cccc(F)c3C(=O)O)CC2)c2ccccc21	10.1021/jm0498203
		CHEMBL376025	137858	0	None	-	0	Guinea pig	6.3	pIC50	=	6.3	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	454	10	1	5	4.8	CCOCCn1cc(C2CCN(CCOc3cccc(F)c3C(=O)O)CC2)c2ccccc21	10.1021/jm0498203
		11373970	141973	0	None	-	0	Guinea pig	6.3	pIC50	=	6.3	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	436	9	1	5	4.8	CCOCCn1cc(C2CCN(Cc3cccc(C(=O)O)c3)CC2)c2cc(OC)ccc21	10.1021/jm0498203
		CHEMBL387325	141973	0	None	-	0	Guinea pig	6.3	pIC50	=	6.3	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	436	9	1	5	4.8	CCOCCn1cc(C2CCN(Cc3cccc(C(=O)O)c3)CC2)c2cc(OC)ccc21	10.1021/jm0498203
		10263017	207462	2	None	-	3	Human	6.3	pIC50	=	6.3	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	223	10	2	2	3.0	NCCCCCCCCCCc1c[nH]cn1	10.1021/jm030936t
		CHEMBL94249	207462	2	None	-	3	Human	6.3	pIC50	=	6.3	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	223	10	2	2	3.0	NCCCCCCCCCCc1c[nH]cn1	10.1021/jm030936t
		44369359	46881	1	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	255	3	2	2	2.9	NCCc1c[nH]c(-c2ccc(Cl)c(Cl)c2)n1	10.1021/jm030936t
		CHEMBL154068	46881	1	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	255	3	2	2	2.9	NCCc1c[nH]c(-c2ccc(Cl)c(Cl)c2)n1	10.1021/jm030936t
		657255	199084	34	None	-18	15	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	nan
		CHEMBL588119	199084	34	None	-18	15	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	nan
		148123909	170233	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	505	6	1	6	5.1	O=[N+]([O-])c1ccccc1OCC(O)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/j.bmcl.2019.126712
		CHEMBL4445636	170233	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	505	6	1	6	5.1	O=[N+]([O-])c1ccccc1OCC(O)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/j.bmcl.2019.126712
		14762600	164451	0	None	-	0	Guinea pig	6.3	pIC50	=	6.3	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	363	5	1	3	3.3	CCc1ccccc1NC(=O)CCN1CCN2Cc3ccccc3CC2C1	10.1021/jm00173a011
		CHEMBL421393	164451	0	None	-	0	Guinea pig	6.3	pIC50	=	6.3	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	363	5	1	3	3.3	CCc1ccccc1NC(=O)CCN1CCN2Cc3ccccc3CC2C1	10.1021/jm00173a011
		45269063	196186	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	549	8	1	9	3.6	CN(CCCN1CCC(CN2c3ccccc3Sc3ccc(C(=O)O)cc32)CC1)c1cc(=O)n(C)c(=O)n1C	10.1016/j.bmcl.2009.03.124
		CHEMBL561377	196186	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	549	8	1	9	3.6	CN(CCCN1CCC(CN2c3ccccc3Sc3ccc(C(=O)O)cc32)CC1)c1cc(=O)n(C)c(=O)n1C	10.1016/j.bmcl.2009.03.124
		52953079	62001	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	519	6	1	9	2.4	Cn1c(N2CCCN(CCCN3c4cc(C(=O)O)ccc4COc4ccccc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmc.2011.03.003
		CHEMBL1774496	62001	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	519	6	1	9	2.4	Cn1c(N2CCCN(CCCN3c4cc(C(=O)O)ccc4COc4ccccc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmc.2011.03.003
		286016	4416	8	None	-	0	Guinea pig	6.3	pIC50	=	6.3	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	227	0	2	2	1.5	c1ccc2c3c([nH]c2c1)CN1CCNCC1C3	10.1021/jm00173a011
		CHEMBL101491	4416	8	None	-	0	Guinea pig	6.3	pIC50	=	6.3	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	227	0	2	2	1.5	c1ccc2c3c([nH]c2c1)CN1CCNCC1C3	10.1021/jm00173a011
		54586254	62003	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	531	7	1	8	2.6	Cn1c(N2CCCN(CCCN3c4ccccc4CCc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmc.2011.03.003
		CHEMBL1774498	62003	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	531	7	1	8	2.6	Cn1c(N2CCCN(CCCN3c4ccccc4CCc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmc.2011.03.003
		54584335	62006	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	516	6	1	8	2.2	Cn1c(N2CCN(CC/C=C3\c4ccccc4COc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmc.2011.03.003
		CHEMBL1774501	62006	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	516	6	1	8	2.2	Cn1c(N2CCN(CC/C=C3\c4ccccc4COc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmc.2011.03.003
		17964355	126453	0	None	-	0	Guinea pig	6.3	pIC50	=	6.3	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	414	6	1	4	5.4	O=C(O)c1cccc(CN2CCC(c3cn(Cc4ccoc4)c4ccccc34)CC2)c1	10.1016/j.bmcl.2004.12.008
		CHEMBL365197	126453	0	None	-	0	Guinea pig	6.3	pIC50	=	6.3	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	414	6	1	4	5.4	O=C(O)c1cccc(CN2CCC(c3cn(Cc4ccoc4)c4ccccc34)CC2)c1	10.1016/j.bmcl.2004.12.008
		14762591	4216	2	None	-	0	Guinea pig	6.3	pIC50	=	6.3	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	356	6	1	2	4.6	O=C(CCN1CCC(Cc2ccccc2)CC1)Nc1ccccc1Cl	10.1021/jm00173a011
		CHEMBL100276	4216	2	None	-	0	Guinea pig	6.3	pIC50	=	6.3	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	356	6	1	2	4.6	O=C(CCN1CCC(Cc2ccccc2)CC1)Nc1ccccc1Cl	10.1021/jm00173a011
		10298838	168794	0	None	-	0	Guinea pig	6.2	pIC50	=	6.2	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	469	9	1	5	5.2	O=C(O)c1ccccc1OCCN1CCC(c2cn(CCc3ccccn3)c3ccccc23)CC1	10.1021/jm0498203
		CHEMBL437519	168794	0	None	-	0	Guinea pig	6.2	pIC50	=	6.2	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	469	9	1	5	5.2	O=C(O)c1ccccc1OCCN1CCC(c2cn(CCc3ccccn3)c3ccccc23)CC1	10.1021/jm0498203
		22322323	196017	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	440	7	1	7	2.7	Cn1c(NCCCN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)cc(=O)n(C)c1=O	10.1016/j.bmcl.2009.03.124
		CHEMBL560120	196017	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	440	7	1	7	2.7	Cn1c(NCCCN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)cc(=O)n(C)c1=O	10.1016/j.bmcl.2009.03.124
		10917690	207605	1	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibitory concentration against histamine H1 receptorInhibitory concentration against histamine H1 receptor	ChEMBL	471	8	0	5	5.4	COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1	10.1021/jm058225d
		CHEMBL95051	207605	1	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibitory concentration against histamine H1 receptorInhibitory concentration against histamine H1 receptor	ChEMBL	471	8	0	5	5.4	COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1	10.1021/jm058225d
		44318461	205735	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.	ChEMBL	308	2	0	3	3.7	Cc1cccc2c1Cc1ccccc1C1CC(CN(C)C)ON21	10.1016/s0960-894x(01)00721-1
		CHEMBL82635	205735	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.	ChEMBL	308	2	0	3	3.7	Cc1cccc2c1Cc1ccccc1C1CC(CN(C)C)ON21	10.1016/s0960-894x(01)00721-1
		1227	2489	43	None	-2	12	Human	8.2	pIC50	=	8.2	Binding	Displacement of radiolabeled pyrilamine from human histamine H1 receptorDisplacement of radiolabeled pyrilamine from human histamine H1 receptor	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm8007618
		2331	2489	43	None	-2	12	Human	8.2	pIC50	=	8.2	Binding	Displacement of radiolabeled pyrilamine from human histamine H1 receptorDisplacement of radiolabeled pyrilamine from human histamine H1 receptor	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm8007618
		3957	2489	43	None	-2	12	Human	8.2	pIC50	=	8.2	Binding	Displacement of radiolabeled pyrilamine from human histamine H1 receptorDisplacement of radiolabeled pyrilamine from human histamine H1 receptor	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm8007618
		4992	2489	43	None	-2	12	Human	8.2	pIC50	=	8.2	Binding	Displacement of radiolabeled pyrilamine from human histamine H1 receptorDisplacement of radiolabeled pyrilamine from human histamine H1 receptor	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm8007618
		CHEMBL511	2489	43	None	-2	12	Human	8.2	pIC50	=	8.2	Binding	Displacement of radiolabeled pyrilamine from human histamine H1 receptorDisplacement of radiolabeled pyrilamine from human histamine H1 receptor	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm8007618
		DB06691	2489	43	None	-2	12	Human	8.2	pIC50	=	8.2	Binding	Displacement of radiolabeled pyrilamine from human histamine H1 receptorDisplacement of radiolabeled pyrilamine from human histamine H1 receptor	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm8007618
		147863431	175939	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	460	5	1	4	5.2	OC(COc1ccccc1)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/j.bmcl.2019.126712
		CHEMBL4587694	175939	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	460	5	1	4	5.2	OC(COc1ccccc1)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/j.bmcl.2019.126712
		1210	918	51	None	-20	21	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		1213	918	51	None	-20	21	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		2725	918	51	None	-20	21	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		33036	918	51	None	-20	21	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		4411	918	51	None	-20	21	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		616	918	51	None	-20	21	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		6976	918	51	None	-20	21	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		716121	918	51	None	-20	21	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		CHEMBL1201353	918	51	None	-20	21	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		CHEMBL1554789	918	51	None	-20	21	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		CHEMBL505	918	51	None	-20	21	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		DB01114	918	51	None	-20	21	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		DB13679	918	51	None	-20	21	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		9904205	205850	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity against Histamine H1 receptorBinding affinity against Histamine H1 receptor	ChEMBL	294	2	0	3	3.4	CN(C)CC1CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(02)00796-5
		CHEMBL83658	205850	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity against Histamine H1 receptorBinding affinity against Histamine H1 receptor	ChEMBL	294	2	0	3	3.4	CN(C)CC1CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(02)00796-5
		9904205	205850	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.	ChEMBL	294	2	0	3	3.4	CN(C)CC1CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
		CHEMBL83658	205850	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.	ChEMBL	294	2	0	3	3.4	CN(C)CC1CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
		9904205	205850	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligandBinding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligand	ChEMBL	294	2	0	3	3.4	CN(C)CC1CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
		CHEMBL83658	205850	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligandBinding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligand	ChEMBL	294	2	0	3	3.4	CN(C)CC1CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
		16005860	187406	7	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	388	5	1	2	4.8	CC(C)(C)CCN1CC[C@H](CNC(=O)c2cc(Cl)cc(Cl)c2)[C@H](F)C1	10.1021/jm800830n
		CHEMBL493677	187406	7	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	388	5	1	2	4.8	CC(C)(C)CCN1CC[C@H](CNC(=O)c2cc(Cl)cc(Cl)c2)[C@H](F)C1	10.1021/jm800830n
		44461456	205749	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligandBinding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligand	ChEMBL	308	2	0	3	3.8	CN(C)CC1(C)CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
		CHEMBL82714	205749	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligandBinding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligand	ChEMBL	308	2	0	3	3.8	CN(C)CC1(C)CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
		11508317	8140	0	None	-	1	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	336	5	0	3	5.1	C[C@@H](c1ccccn1)c1c(CCN2CCCC2)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		CHEMBL1091774	8140	0	None	-	1	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	336	5	0	3	5.1	C[C@@H](c1ccccn1)c1c(CCN2CCCC2)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		40466858	16155	67	None	-	0	Guinea pig	5.2	pIC50	=	5.2	Binding	Inhibition of H1 receptor in Cavia porcellus Hartley (guinea pig) ileum assessed as inhibition of histamine-induced spasms incubated 2 min prior histamine-challengeInhibition of H1 receptor in Cavia porcellus Hartley (guinea pig) ileum assessed as inhibition of histamine-induced spasms incubated 2 min prior histamine-challenge	ChEMBL	348	6	1	3	4.0	Cc1ccc(/C(=C\CN2CCCC2)c2cccc(/C=C/C(=O)O)n2)cc1	10.1007/s00044-008-9119-y
		5284514	16155	67	None	-	0	Guinea pig	5.2	pIC50	=	5.2	Binding	Inhibition of H1 receptor in Cavia porcellus Hartley (guinea pig) ileum assessed as inhibition of histamine-induced spasms incubated 2 min prior histamine-challengeInhibition of H1 receptor in Cavia porcellus Hartley (guinea pig) ileum assessed as inhibition of histamine-induced spasms incubated 2 min prior histamine-challenge	ChEMBL	348	6	1	3	4.0	Cc1ccc(/C(=C\CN2CCCC2)c2cccc(/C=C/C(=O)O)n2)cc1	10.1007/s00044-008-9119-y
		CHEMBL1224	16155	67	None	-	0	Guinea pig	5.2	pIC50	=	5.2	Binding	Inhibition of H1 receptor in Cavia porcellus Hartley (guinea pig) ileum assessed as inhibition of histamine-induced spasms incubated 2 min prior histamine-challengeInhibition of H1 receptor in Cavia porcellus Hartley (guinea pig) ileum assessed as inhibition of histamine-induced spasms incubated 2 min prior histamine-challenge	ChEMBL	348	6	1	3	4.0	Cc1ccc(/C(=C\CN2CCCC2)c2cccc(/C=C/C(=O)O)n2)cc1	10.1007/s00044-008-9119-y
		136224310	85389	0	None	-	0	Guinea pig	5.2	pIC50	=	5.2	Binding	Inhibition of H1 receptor in Cavia porcellus Hartley (guinea pig) ileum assessed as inhibition of histamine-induced spasms incubated 2 min prior histamine-challengeInhibition of H1 receptor in Cavia porcellus Hartley (guinea pig) ileum assessed as inhibition of histamine-induced spasms incubated 2 min prior histamine-challenge	ChEMBL	227	3	4	5	-1.4	CC(C)(CO)NC=C1C(=O)NC(=O)NC1=O	10.1007/s00044-008-9119-y
		CHEMBL2262481	85389	0	None	-	0	Guinea pig	5.2	pIC50	=	5.2	Binding	Inhibition of H1 receptor in Cavia porcellus Hartley (guinea pig) ileum assessed as inhibition of histamine-induced spasms incubated 2 min prior histamine-challengeInhibition of H1 receptor in Cavia porcellus Hartley (guinea pig) ileum assessed as inhibition of histamine-induced spasms incubated 2 min prior histamine-challenge	ChEMBL	227	3	4	5	-1.4	CC(C)(CO)NC=C1C(=O)NC(=O)NC1=O	10.1007/s00044-008-9119-y
		54586256	62009	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	516	5	1	8	2.7	Cn1c(N2CCCN(CC/C=C3/c4ccccc4COc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmc.2011.03.003
		CHEMBL1774504	62009	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	516	5	1	8	2.7	Cn1c(N2CCCN(CC/C=C3/c4ccccc4COc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmc.2011.03.003
		44271504	59717	0	None	-	0	Guinea pig	7.2	pIC50	=	7.2	Binding	Inhibitory activity against Tritiated [3H]- mepyramine binding to histamine H1 receptor in guinea pig cerebral cortexInhibitory activity against Tritiated [3H]- mepyramine binding to histamine H1 receptor in guinea pig cerebral cortex	ChEMBL	495	9	1	5	5.2	COC(=O)c1ccc(OCCCN2CCC(C(O)(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm00121a022
		CHEMBL17237	59717	0	None	-	0	Guinea pig	7.2	pIC50	=	7.2	Binding	Inhibitory activity against Tritiated [3H]- mepyramine binding to histamine H1 receptor in guinea pig cerebral cortexInhibitory activity against Tritiated [3H]- mepyramine binding to histamine H1 receptor in guinea pig cerebral cortex	ChEMBL	495	9	1	5	5.2	COC(=O)c1ccc(OCCCN2CCC(C(O)(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm00121a022
		11230427	44721	1	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	249	9	1	2	3.4	c1nc(CCCCCCCCN2CCCC2)c[nH]1	10.1021/jm030936t
		CHEMBL152126	44721	1	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	249	9	1	2	3.4	c1nc(CCCCCCCCN2CCCC2)c[nH]1	10.1021/jm030936t
		14762595	4444	0	None	-	0	Guinea pig	6.2	pIC50	=	6.2	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	402	5	2	3	3.8	CCc1ccccc1NC(=O)CCN1CCN2Cc3[nH]c4ccccc4c3CC2C1	10.1021/jm00173a011
		CHEMBL101625	4444	0	None	-	0	Guinea pig	6.2	pIC50	=	6.2	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	402	5	2	3	3.8	CCc1ccccc1NC(=O)CCN1CCN2Cc3[nH]c4ccccc4c3CC2C1	10.1021/jm00173a011
		1210	918	51	None	-20	21	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]pyrilamine from human histamine receptor subtype 1 expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine receptor subtype 1 expressed in CHO cells	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1128/aac.00669-07
		1213	918	51	None	-20	21	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]pyrilamine from human histamine receptor subtype 1 expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine receptor subtype 1 expressed in CHO cells	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1128/aac.00669-07
		2725	918	51	None	-20	21	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]pyrilamine from human histamine receptor subtype 1 expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine receptor subtype 1 expressed in CHO cells	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1128/aac.00669-07
		33036	918	51	None	-20	21	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]pyrilamine from human histamine receptor subtype 1 expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine receptor subtype 1 expressed in CHO cells	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1128/aac.00669-07
		4411	918	51	None	-20	21	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]pyrilamine from human histamine receptor subtype 1 expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine receptor subtype 1 expressed in CHO cells	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1128/aac.00669-07
		616	918	51	None	-20	21	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]pyrilamine from human histamine receptor subtype 1 expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine receptor subtype 1 expressed in CHO cells	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1128/aac.00669-07
		6976	918	51	None	-20	21	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]pyrilamine from human histamine receptor subtype 1 expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine receptor subtype 1 expressed in CHO cells	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1128/aac.00669-07
		716121	918	51	None	-20	21	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]pyrilamine from human histamine receptor subtype 1 expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine receptor subtype 1 expressed in CHO cells	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1128/aac.00669-07
		CHEMBL1201353	918	51	None	-20	21	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]pyrilamine from human histamine receptor subtype 1 expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine receptor subtype 1 expressed in CHO cells	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1128/aac.00669-07
		CHEMBL1554789	918	51	None	-20	21	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]pyrilamine from human histamine receptor subtype 1 expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine receptor subtype 1 expressed in CHO cells	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1128/aac.00669-07
		CHEMBL505	918	51	None	-20	21	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]pyrilamine from human histamine receptor subtype 1 expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine receptor subtype 1 expressed in CHO cells	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1128/aac.00669-07
		DB01114	918	51	None	-20	21	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]pyrilamine from human histamine receptor subtype 1 expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine receptor subtype 1 expressed in CHO cells	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1128/aac.00669-07
		DB13679	918	51	None	-20	21	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]pyrilamine from human histamine receptor subtype 1 expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine receptor subtype 1 expressed in CHO cells	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1128/aac.00669-07
		14762575	4184	0	None	-	0	Guinea pig	6.2	pIC50	=	6.2	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	400	6	1	2	4.1	O=C(NCCN1CCC(Cc2ccccc2)CC1)c1ccccc1Br	10.1021/jm00173a011
		CHEMBL100125	4184	0	None	-	0	Guinea pig	6.2	pIC50	=	6.2	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	400	6	1	2	4.1	O=C(NCCN1CCC(Cc2ccccc2)CC1)c1ccccc1Br	10.1021/jm00173a011
		44461565	104350	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Binding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligandBinding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligand	ChEMBL	322	4	0	3	4.2	CN(C)CCCC1CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
		CHEMBL310018	104350	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Binding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligandBinding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligand	ChEMBL	322	4	0	3	4.2	CN(C)CCCC1CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
		4919	206234	23	None	-	8	Rat	5.2	pIC50	=	5.2	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1021/jm300671m
		CHEMBL86715	206234	23	None	-	8	Rat	5.2	pIC50	=	5.2	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1021/jm300671m
		14762601	108361	1	None	-	0	Guinea pig	6.2	pIC50	=	6.2	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	369	4	1	3	3.4	O=C(CCN1CCN2Cc3ccccc3CC2C1)Nc1ccccc1Cl	10.1021/jm00173a011
		CHEMBL319817	108361	1	None	-	0	Guinea pig	6.2	pIC50	=	6.2	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	369	4	1	3	3.4	O=C(CCN1CCN2Cc3ccccc3CC2C1)Nc1ccccc1Cl	10.1021/jm00173a011
		45267329	196008	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	549	8	1	9	3.3	Cn1c(N2CCCN(CCCN3c4ccccc4Sc4ccc(CCC(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmcl.2009.03.124
		CHEMBL560061	196008	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	549	8	1	9	3.3	Cn1c(N2CCCN(CCCN3c4ccccc4Sc4ccc(CCC(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmcl.2009.03.124
		10478188	122942	0	None	-	0	Guinea pig	6.2	pIC50	=	6.2	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	436	9	1	5	4.8	CCOCCn1cc(C2CCN(Cc3ccc(OC)c(C(=O)O)c3)CC2)c2ccccc21	10.1016/j.bmcl.2004.12.008
		CHEMBL360712	122942	0	None	-	0	Guinea pig	6.2	pIC50	=	6.2	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	436	9	1	5	4.8	CCOCCn1cc(C2CCN(Cc3ccc(OC)c(C(=O)O)c3)CC2)c2ccccc21	10.1016/j.bmcl.2004.12.008
		14762573	4482	2	None	-	0	Guinea pig	5.2	pIC50	=	5.2	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	323	6	1	3	2.2	O=C(NCCN1CCN(Cc2ccccc2)CC1)c1ccccc1	10.1021/jm00173a011
		CHEMBL101927	4482	2	None	-	0	Guinea pig	5.2	pIC50	=	5.2	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	323	6	1	3	2.2	O=C(NCCN1CCN(Cc2ccccc2)CC1)c1ccccc1	10.1021/jm00173a011
		14762568	109222	2	None	-	0	Guinea pig	6.2	pIC50	=	6.2	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	357	6	1	3	2.9	O=C(NCCN1CCN(Cc2ccccc2)CC1)c1ccccc1Cl	10.1021/jm00173a011
		CHEMBL321738	109222	2	None	-	0	Guinea pig	6.2	pIC50	=	6.2	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	357	6	1	3	2.9	O=C(NCCN1CCN(Cc2ccccc2)CC1)c1ccccc1Cl	10.1021/jm00173a011
		44318695	107005	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.	ChEMBL	370	3	0	3	5.1	CN(C)CC1CC2c3ccccc3Cc3ccc(-c4ccccc4)cc3N2O1	10.1016/s0960-894x(01)00721-1
		CHEMBL315308	107005	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.Binding affinity at human cloned Histamine H1 receptor expressed in CHO cells by [3H]pyrilamine displacement.	ChEMBL	370	3	0	3	5.1	CN(C)CC1CC2c3ccccc3Cc3ccc(-c4ccccc4)cc3N2O1	10.1016/s0960-894x(01)00721-1
		16722761	62002	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	517	6	1	8	2.6	Cn1c(N2CCCN(CCCN3c4ccccc4CCc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmc.2011.03.003
		CHEMBL1774497	62002	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	517	6	1	8	2.6	Cn1c(N2CCCN(CCCN3c4ccccc4CCc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmc.2011.03.003
		44392642	65252	0	None	-	0	Guinea pig	7.2	pIC50	=	7.2	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	478	8	1	5	5.9	O=C(O)c1ccc(Cl)cc1OCCN1CCC(c2cn(Cc3ccoc3)c3ccccc23)CC1	10.1016/j.bmcl.2004.12.008
		CHEMBL182758	65252	0	None	-	0	Guinea pig	7.2	pIC50	=	7.2	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	478	8	1	5	5.9	O=C(O)c1ccc(Cl)cc1OCCN1CCC(c2cn(Cc3ccoc3)c3ccccc23)CC1	10.1016/j.bmcl.2004.12.008
		2253940	67254	11	None	-	0	Guinea pig	5.2	pIC50	=	5.2	Binding	Inhibition of H1 receptor in Cavia porcellus Hartley (guinea pig) ileum assessed as inhibition of histamine-induced spasms incubated 2 min prior histamine-challengeInhibition of H1 receptor in Cavia porcellus Hartley (guinea pig) ileum assessed as inhibition of histamine-induced spasms incubated 2 min prior histamine-challenge	ChEMBL	237	2	3	4	0.2	O=C1NC(=O)C(=CNC2CCCCC2)C(=O)N1	10.1007/s00044-008-9119-y
		CHEMBL1880624	67254	11	None	-	0	Guinea pig	5.2	pIC50	=	5.2	Binding	Inhibition of H1 receptor in Cavia porcellus Hartley (guinea pig) ileum assessed as inhibition of histamine-induced spasms incubated 2 min prior histamine-challengeInhibition of H1 receptor in Cavia porcellus Hartley (guinea pig) ileum assessed as inhibition of histamine-induced spasms incubated 2 min prior histamine-challenge	ChEMBL	237	2	3	4	0.2	O=C1NC(=O)C(=CNC2CCCCC2)C(=O)N1	10.1007/s00044-008-9119-y
		14762572	111578	1	None	-	0	Guinea pig	5.2	pIC50	=	5.2	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	337	6	1	3	2.5	Cc1ccccc1C(=O)NCCN1CCN(Cc2ccccc2)CC1	10.1021/jm00173a011
		CHEMBL328170	111578	1	None	-	0	Guinea pig	5.2	pIC50	=	5.2	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	337	6	1	3	2.5	Cc1ccccc1C(=O)NCCN1CCN(Cc2ccccc2)CC1	10.1021/jm00173a011
		100	3805	58	None	-7	55	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		2637	3805	58	None	-7	55	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		5452	3805	58	None	-7	55	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		CHEMBL479	3805	58	None	-7	55	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		DB00679	3805	58	None	-7	55	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		45270755	196736	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	549	7	1	9	3.5	CC(C(=O)O)c1ccc2c(c1)N(CCCN1CCCN(c3cc(=O)n(C)c(=O)n3C)CC1)c1ccccc1S2	10.1016/j.bmcl.2009.03.124
		CHEMBL565083	196736	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	549	7	1	9	3.5	CC(C(=O)O)c1ccc2c(c1)N(CCCN1CCCN(c3cc(=O)n(C)c(=O)n3C)CC1)c1ccccc1S2	10.1016/j.bmcl.2009.03.124
		135515198	104750	8	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligandBinding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligand	ChEMBL	440	2	1	7	3.3	CN1CCN(C2=Nc3cc(OS(=O)(=O)C(F)(F)F)ccc3Nc3ccccc32)CC1	10.1021/jm991005d
		CHEMBL310712	104750	8	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligandBinding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligand	ChEMBL	440	2	1	7	3.3	CN1CCN(C2=Nc3cc(OS(=O)(=O)C(F)(F)F)ccc3Nc3ccccc32)CC1	10.1021/jm991005d
		135515198	104750	8	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inhibitory binding of [3H]mepyramine to histamine H1 receptors in rat brain membranesInhibitory binding of [3H]mepyramine to histamine H1 receptors in rat brain membranes	ChEMBL	440	2	1	7	3.3	CN1CCN(C2=Nc3cc(OS(=O)(=O)C(F)(F)F)ccc3Nc3ccccc32)CC1	10.1021/jm9704457
		CHEMBL310712	104750	8	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inhibitory binding of [3H]mepyramine to histamine H1 receptors in rat brain membranesInhibitory binding of [3H]mepyramine to histamine H1 receptors in rat brain membranes	ChEMBL	440	2	1	7	3.3	CN1CCN(C2=Nc3cc(OS(=O)(=O)C(F)(F)F)ccc3Nc3ccccc32)CC1	10.1021/jm9704457
		1547484	940	74	None	-1	20	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		654	940	74	None	-1	20	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		9072	940	74	None	-1	20	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		CHEMBL43064	940	74	None	-1	20	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		DB00568	940	74	None	-1	20	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		54586255	62004	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	559	7	1	8	3.3	Cn1c(N2CCCN(CCCN3c4ccccc4CCc4ccc(C(C)(C)C(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmc.2011.03.003
		CHEMBL1774499	62004	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	559	7	1	8	3.3	Cn1c(N2CCCN(CCCN3c4ccccc4CCc4ccc(C(C)(C)C(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmc.2011.03.003
		11293983	84291	0	None	-	0	Guinea pig	7.1	pIC50	=	7.1	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	454	10	1	5	4.8	CCOCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2ccc(F)cc21	10.1021/jm0498203
		CHEMBL221413	84291	0	None	-	0	Guinea pig	7.1	pIC50	=	7.1	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	454	10	1	5	4.8	CCOCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2ccc(F)cc21	10.1021/jm0498203
		23027411	198520	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptorDisplacement of [3H]pyrilamine from human histamine H1 receptor	ChEMBL	387	5	2	5	3.7	Cc1cnc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)cc3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
		CHEMBL577912	198520	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptorDisplacement of [3H]pyrilamine from human histamine H1 receptor	ChEMBL	387	5	2	5	3.7	Cc1cnc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)cc3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
		14762584	4357	1	None	-	0	Guinea pig	6.1	pIC50	=	6.1	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	351	7	1	3	3.4	CCc1ccccc1NC(=O)CCN1CCN(Cc2ccccc2)CC1	10.1021/jm00173a011
		CHEMBL101088	4357	1	None	-	0	Guinea pig	6.1	pIC50	=	6.1	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	351	7	1	3	3.4	CCc1ccccc1NC(=O)CCN1CCN(Cc2ccccc2)CC1	10.1021/jm00173a011
		1170	1633	75	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1016/j.bmc.2011.03.003
		3348	1633	75	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1016/j.bmc.2011.03.003
		4819	1633	75	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1016/j.bmc.2011.03.003
		74685737	1633	75	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1016/j.bmc.2011.03.003
		CHEMBL914	1633	75	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1016/j.bmc.2011.03.003
		DB00950	1633	75	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1016/j.bmc.2011.03.003
		1170	1633	75	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1016/j.bmcl.2009.03.124
		3348	1633	75	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1016/j.bmcl.2009.03.124
		4819	1633	75	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1016/j.bmcl.2009.03.124
		74685737	1633	75	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1016/j.bmcl.2009.03.124
		CHEMBL914	1633	75	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1016/j.bmcl.2009.03.124
		DB00950	1633	75	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1016/j.bmcl.2009.03.124
		1170	1633	75	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1016/j.bmcl.2009.03.124
		3348	1633	75	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1016/j.bmcl.2009.03.124
		4819	1633	75	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1016/j.bmcl.2009.03.124
		74685737	1633	75	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1016/j.bmcl.2009.03.124
		CHEMBL914	1633	75	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1016/j.bmcl.2009.03.124
		DB00950	1633	75	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1016/j.bmcl.2009.03.124
		10447834	1933	4	None	-1862	5	Human	6.1	pIC50	=	6.1	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm030936t
		4026	1933	4	None	-1862	5	Human	6.1	pIC50	=	6.1	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm030936t
		CHEMBL275507	1933	4	None	-1862	5	Human	6.1	pIC50	=	6.1	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	10.1021/jm030936t
		11816882	47504	1	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	220	9	1	2	3.3	NCCCCCCCCCc1ccccn1	10.1021/jm030936t
		CHEMBL154566	47504	1	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibitory activity against human Histamine H1 receptorInhibitory activity against human Histamine H1 receptor	ChEMBL	220	9	1	2	3.3	NCCCCCCCCCc1ccccn1	10.1021/jm030936t
		10885636	111016	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	503	9	0	4	5.7	N#Cc1ccc(CCOC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
		CHEMBL326263	111016	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	503	9	0	4	5.7	N#Cc1ccc(CCOC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
		14762576	4465	1	None	-	0	Guinea pig	6.1	pIC50	=	6.1	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	356	6	1	2	4.0	O=C(NCCN1CCC(Cc2ccccc2)CC1)c1ccccc1Cl	10.1021/jm00173a011
		CHEMBL101758	4465	1	None	-	0	Guinea pig	6.1	pIC50	=	6.1	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	356	6	1	2	4.0	O=C(NCCN1CCC(Cc2ccccc2)CC1)c1ccccc1Cl	10.1021/jm00173a011
		173727	60299	15	None	-	0	Guinea pig	8.1	pIC50	=	8.1	Binding	Inhibitory activity against Tritiated [3H]- mepyramine binding to histamine H1 receptor in guinea pig cerebral cortexInhibitory activity against Tritiated [3H]- mepyramine binding to histamine H1 receptor in guinea pig cerebral cortex	ChEMBL	509	10	1	5	5.6	COc1cc(C(C)=O)ccc1OCCCN1CCC(C(O)(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm00121a022
		CHEMBL17436	60299	15	None	-	0	Guinea pig	8.1	pIC50	=	8.1	Binding	Inhibitory activity against Tritiated [3H]- mepyramine binding to histamine H1 receptor in guinea pig cerebral cortexInhibitory activity against Tritiated [3H]- mepyramine binding to histamine H1 receptor in guinea pig cerebral cortex	ChEMBL	509	10	1	5	5.6	COc1cc(C(C)=O)ccc1OCCCN1CCC(C(O)(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm00121a022
		155522480	170649	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	490	6	1	5	5.2	COc1cccc(OCC(O)CN2CCC(=C3c4ccc(Cl)cc4CCc4cccnc43)CC2)c1	10.1016/j.bmcl.2019.126712
		CHEMBL4451332	170649	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	490	6	1	5	5.2	COc1cccc(OCC(O)CN2CCC(=C3c4ccc(Cl)cc4CCc4cccnc43)CC2)c1	10.1016/j.bmcl.2019.126712
		4011	82408	49	None	6	24	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
		CHEMBL21731	82408	49	None	6	24	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
		1210	918	51	None	9	21	Guinea pig	8.1	pIC50	=	8.1	Binding	Inhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortex	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00108a012
		1213	918	51	None	9	21	Guinea pig	8.1	pIC50	=	8.1	Binding	Inhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortex	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00108a012
		2725	918	51	None	9	21	Guinea pig	8.1	pIC50	=	8.1	Binding	Inhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortex	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00108a012
		33036	918	51	None	9	21	Guinea pig	8.1	pIC50	=	8.1	Binding	Inhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortex	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00108a012
		4411	918	51	None	9	21	Guinea pig	8.1	pIC50	=	8.1	Binding	Inhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortex	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00108a012
		616	918	51	None	9	21	Guinea pig	8.1	pIC50	=	8.1	Binding	Inhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortex	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00108a012
		6976	918	51	None	9	21	Guinea pig	8.1	pIC50	=	8.1	Binding	Inhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortex	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00108a012
		716121	918	51	None	9	21	Guinea pig	8.1	pIC50	=	8.1	Binding	Inhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortex	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00108a012
		CHEMBL1201353	918	51	None	9	21	Guinea pig	8.1	pIC50	=	8.1	Binding	Inhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortex	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00108a012
		CHEMBL1554789	918	51	None	9	21	Guinea pig	8.1	pIC50	=	8.1	Binding	Inhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortex	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00108a012
		CHEMBL505	918	51	None	9	21	Guinea pig	8.1	pIC50	=	8.1	Binding	Inhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortex	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00108a012
		DB01114	918	51	None	9	21	Guinea pig	8.1	pIC50	=	8.1	Binding	Inhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortex	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00108a012
		DB13679	918	51	None	9	21	Guinea pig	8.1	pIC50	=	8.1	Binding	Inhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortex	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00108a012
		155549599	173853	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	474	5	1	4	5.5	Cc1ccccc1OCC(O)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/j.bmcl.2019.126712
		CHEMBL4539150	173853	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	474	5	1	4	5.5	Cc1ccccc1OCC(O)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/j.bmcl.2019.126712
		2389	3331	118	None	-346	67	Rat	7.1	pIC50	=	7.1	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1073/pnas.0611417104
		5073	3331	118	None	-346	67	Rat	7.1	pIC50	=	7.1	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1073/pnas.0611417104
		96	3331	118	None	-346	67	Rat	7.1	pIC50	=	7.1	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1073/pnas.0611417104
		CHEMBL85	3331	118	None	-346	67	Rat	7.1	pIC50	=	7.1	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1073/pnas.0611417104
		DB00734	3331	118	None	-346	67	Rat	7.1	pIC50	=	7.1	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1073/pnas.0611417104
		11329753	84563	0	None	-	0	Guinea pig	7.1	pIC50	=	7.1	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	514	10	1	5	5.4	CCOCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2cccc(Br)c21	10.1021/jm0498203
		CHEMBL222083	84563	0	None	-	0	Guinea pig	7.1	pIC50	=	7.1	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	514	10	1	5	5.4	CCOCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2cccc(Br)c21	10.1021/jm0498203
		45267775	196232	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	414	5	0	4	5.3	CN(c1ccccc1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1	10.1016/j.bmcl.2009.05.086
		CHEMBL561690	196232	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	414	5	0	4	5.3	CN(c1ccccc1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1	10.1016/j.bmcl.2009.05.086
		23027245	197128	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptorDisplacement of [3H]pyrilamine from human histamine H1 receptor	ChEMBL	387	5	2	5	3.7	Cc1cc(N(C)C)nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)cc3)CC2)n1	10.1016/j.bmcl.2009.09.003
		CHEMBL567791	197128	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptorDisplacement of [3H]pyrilamine from human histamine H1 receptor	ChEMBL	387	5	2	5	3.7	Cc1cc(N(C)C)nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)cc3)CC2)n1	10.1016/j.bmcl.2009.09.003
		10915140	29474	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of mepyramine binding to Histamine H1 receptorInhibition of mepyramine binding to Histamine H1 receptor	ChEMBL	351	5	0	3	4.2	COC1Cc2ccccc2C2(CCN(CCCc3ccccc3)CC2)O1	10.1021/jm010992z
		CHEMBL138458	29474	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of mepyramine binding to Histamine H1 receptorInhibition of mepyramine binding to Histamine H1 receptor	ChEMBL	351	5	0	3	4.2	COC1Cc2ccccc2C2(CCN(CCCc3ccccc3)CC2)O1	10.1021/jm010992z
		76323071	85391	0	None	-	0	Guinea pig	4.1	pIC50	=	4.1	Binding	Inhibition of H1 receptor in Cavia porcellus Hartley (guinea pig) ileum assessed as inhibition of histamine-induced spasms incubated 2 min prior histamine-challengeInhibition of H1 receptor in Cavia porcellus Hartley (guinea pig) ileum assessed as inhibition of histamine-induced spasms incubated 2 min prior histamine-challenge	ChEMBL	292	7	3	5	0.0	CC(CO)(CO)NCCCN1C(=O)c2ccccc2C1=O	10.1007/s00044-008-9119-y
		CHEMBL2262485	85391	0	None	-	0	Guinea pig	4.1	pIC50	=	4.1	Binding	Inhibition of H1 receptor in Cavia porcellus Hartley (guinea pig) ileum assessed as inhibition of histamine-induced spasms incubated 2 min prior histamine-challengeInhibition of H1 receptor in Cavia porcellus Hartley (guinea pig) ileum assessed as inhibition of histamine-induced spasms incubated 2 min prior histamine-challenge	ChEMBL	292	7	3	5	0.0	CC(CO)(CO)NCCCN1C(=O)c2ccccc2C1=O	10.1007/s00044-008-9119-y
		155545274	174953	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	528	5	1	4	6.2	OC(COc1ccccc1C(F)(F)F)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/j.bmcl.2019.126712
		CHEMBL4565774	174953	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	528	5	1	4	6.2	OC(COc1ccccc1C(F)(F)F)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/j.bmcl.2019.126712
		23027527	196792	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptorDisplacement of [3H]pyrilamine from human histamine H1 receptor	ChEMBL	371	5	2	5	3.1	Cc1cnc(N[C@H]2CC[C@@H](NC(=O)c3ccc(F)cc3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
		CHEMBL565551	196792	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptorDisplacement of [3H]pyrilamine from human histamine H1 receptor	ChEMBL	371	5	2	5	3.1	Cc1cnc(N[C@H]2CC[C@@H](NC(=O)c3ccc(F)cc3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
		46182745	57327	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of radioligand binding to human histamine H1 receptorInhibition of radioligand binding to human histamine H1 receptor	ChEMBL	461	6	1	3	6.2	O=C(O)c1cc(-c2cccc(COc3ccc4c(c3)CN(C3CCCC3)C4=O)c2)ccc1Cl	10.1021/jm3005306
		CHEMBL1651208	57327	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of radioligand binding to human histamine H1 receptorInhibition of radioligand binding to human histamine H1 receptor	ChEMBL	461	6	1	3	6.2	O=C(O)c1cc(-c2cccc(COc3ccc4c(c3)CN(C3CCCC3)C4=O)c2)ccc1Cl	10.1021/jm3005306
		11487026	85015	0	None	-	0	Guinea pig	7.1	pIC50	=	7.1	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	422	9	1	5	4.2	COCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2ccccc21	10.1021/jm0498203
		CHEMBL223889	85015	0	None	-	0	Guinea pig	7.1	pIC50	=	7.1	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	422	9	1	5	4.2	COCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2ccccc21	10.1021/jm0498203
		44461606	105995	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligandBinding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligand	ChEMBL	308	3	0	3	3.8	CN(C)CCC1CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
		CHEMBL313189	105995	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligandBinding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligand	ChEMBL	308	3	0	3	3.8	CN(C)CCC1CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
		14762592	4363	4	None	-	0	Guinea pig	6.1	pIC50	=	6.1	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	340	6	1	2	4.1	O=C(CCN1CCC(Cc2ccccc2)CC1)Nc1ccccc1F	10.1021/jm00173a011
		CHEMBL101133	4363	4	None	-	0	Guinea pig	6.1	pIC50	=	6.1	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	340	6	1	2	4.1	O=C(CCN1CCC(Cc2ccccc2)CC1)Nc1ccccc1F	10.1021/jm00173a011
		1342605	4397	16	None	-	0	Guinea pig	6.1	pIC50	=	6.1	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	357	6	1	3	3.5	O=C(CCN1CCN(Cc2ccccc2)CC1)Nc1ccccc1Cl	10.1021/jm00173a011
		CHEMBL101387	4397	16	None	-	0	Guinea pig	6.1	pIC50	=	6.1	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	357	6	1	3	3.5	O=C(CCN1CCN(Cc2ccccc2)CC1)Nc1ccccc1Cl	10.1021/jm00173a011
		54587281	62005	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	516	6	1	8	2.2	Cn1c(N2CCN(CC/C=C3/c4ccccc4COc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmc.2011.03.003
		CHEMBL1774500	62005	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	516	6	1	8	2.2	Cn1c(N2CCN(CC/C=C3/c4ccccc4COc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmc.2011.03.003
		1224	1432	83	None	-2	13	Human	4.1	pIC50	=	4.1	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		3100	1432	83	None	-2	13	Human	4.1	pIC50	=	4.1	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		8980	1432	83	None	-2	13	Human	4.1	pIC50	=	4.1	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		916	1432	83	None	-2	13	Human	4.1	pIC50	=	4.1	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		CHEMBL657	1432	83	None	-2	13	Human	4.1	pIC50	=	4.1	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		DB01075	1432	83	None	-2	13	Human	4.1	pIC50	=	4.1	Binding	Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.Binding Assay: The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand.	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		1224	1432	83	None	-2	13	Human	4.1	pIC50	=	4.1	Binding	Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		3100	1432	83	None	-2	13	Human	4.1	pIC50	=	4.1	Binding	Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		8980	1432	83	None	-2	13	Human	4.1	pIC50	=	4.1	Binding	Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		916	1432	83	None	-2	13	Human	4.1	pIC50	=	4.1	Binding	Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		CHEMBL657	1432	83	None	-2	13	Human	4.1	pIC50	=	4.1	Binding	Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		DB01075	1432	83	None	-2	13	Human	4.1	pIC50	=	4.1	Binding	Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.Histamine H1 Receptors Binding Assay: Affinities of the test compounds for peripheral human histamine H-1-receptors were assessed using receptor-binding assays. The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determined in the presence of excess unlabeled ligand. [3H]-histamine was used as the ligand in this study and the affinity values were determined according to the Cheng-Prusoff equation.	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		2398	954	62	None	-1	29	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		2801	954	62	None	-1	29	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		701	954	62	None	-1	29	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		CHEMBL415	954	62	None	-1	29	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		DB01242	954	62	None	-1	29	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		11282005	66066	0	None	-	0	Guinea pig	7.1	pIC50	=	7.1	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	436	10	1	5	4.6	CCOCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2ccccc21	10.1021/jm0498203
		CHEMBL183706	66066	0	None	-	0	Guinea pig	7.1	pIC50	=	7.1	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	436	10	1	5	4.6	CCOCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2ccccc21	10.1021/jm0498203
		44392621	66324	0	None	-	0	Guinea pig	7.1	pIC50	=	7.1	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	420	10	0	5	4.7	CCOCCn1cc(C2CCN(CCOc3ccccc3C=O)CC2)c2ccccc21	10.1016/j.bmcl.2004.12.008
		CHEMBL184989	66324	0	None	-	0	Guinea pig	7.1	pIC50	=	7.1	Binding	Inhibitory concentration against histamine-H1 receptorInhibitory concentration against histamine-H1 receptor	ChEMBL	420	10	0	5	4.7	CCOCCn1cc(C2CCN(CCOc3ccccc3C=O)CC2)c2ccccc21	10.1016/j.bmcl.2004.12.008
		2389	3331	118	None	-46	67	Human	6.1	pIC50	=	6.1	Binding	Antagonistic activity at histamine1 receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at histamine1 receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2016.04.087
		5073	3331	118	None	-46	67	Human	6.1	pIC50	=	6.1	Binding	Antagonistic activity at histamine1 receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at histamine1 receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2016.04.087
		96	3331	118	None	-46	67	Human	6.1	pIC50	=	6.1	Binding	Antagonistic activity at histamine1 receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at histamine1 receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2016.04.087
		CHEMBL85	3331	118	None	-46	67	Human	6.1	pIC50	=	6.1	Binding	Antagonistic activity at histamine1 receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at histamine1 receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2016.04.087
		DB00734	3331	118	None	-46	67	Human	6.1	pIC50	=	6.1	Binding	Antagonistic activity at histamine1 receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at histamine1 receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2016.04.087
		21177786	85390	0	None	-	0	Guinea pig	4.1	pIC50	=	4.1	Binding	Inhibition of H1 receptor in Cavia porcellus Hartley (guinea pig) ileum assessed as inhibition of histamine-induced spasms incubated 2 min prior histamine-challengeInhibition of H1 receptor in Cavia porcellus Hartley (guinea pig) ileum assessed as inhibition of histamine-induced spasms incubated 2 min prior histamine-challenge	ChEMBL	225	1	2	5	-1.4	O=C1NC(=O)C(=CN2CCOCC2)C(=O)N1	10.1007/s00044-008-9119-y
		CHEMBL2262482	85390	0	None	-	0	Guinea pig	4.1	pIC50	=	4.1	Binding	Inhibition of H1 receptor in Cavia porcellus Hartley (guinea pig) ileum assessed as inhibition of histamine-induced spasms incubated 2 min prior histamine-challengeInhibition of H1 receptor in Cavia porcellus Hartley (guinea pig) ileum assessed as inhibition of histamine-induced spasms incubated 2 min prior histamine-challenge	ChEMBL	225	1	2	5	-1.4	O=C1NC(=O)C(=CN2CCOCC2)C(=O)N1	10.1007/s00044-008-9119-y
		10273238	84754	0	None	-	0	Guinea pig	7.1	pIC50	=	7.1	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	414	6	1	4	5.4	O=C(O)c1cccc(CN2CCC(c3cn(Cc4ccco4)c4ccccc34)CC2)c1	10.1021/jm0498203
		CHEMBL222985	84754	0	None	-	0	Guinea pig	7.1	pIC50	=	7.1	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	414	6	1	4	5.4	O=C(O)c1cccc(CN2CCC(c3cn(Cc4ccco4)c4ccccc34)CC2)c1	10.1021/jm0498203
		13726622	94578	0	None	-	0	Guinea pig	6.1	pIC50	=	6.1	Binding	Inhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortex	ChEMBL	311	3	0	4	2.2	CN1C[C@H](CCN2CCC2)Oc2ncc(Cl)cc2C1=S	10.1021/jm00108a012
		CHEMBL25198	94578	0	None	-	0	Guinea pig	6.1	pIC50	=	6.1	Binding	Inhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortex	ChEMBL	311	3	0	4	2.2	CN1C[C@H](CCN2CCC2)Oc2ncc(Cl)cc2C1=S	10.1021/jm00108a012
		45273362	196473	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	551	8	1	10	2.8	Cn1c(N2CCCN(CCCN3c4ccccc4Sc4ccc(OCC(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmcl.2009.03.124
		CHEMBL563271	196473	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	ChEMBL	551	8	1	10	2.8	Cn1c(N2CCCN(CCCN3c4ccccc4Sc4ccc(OCC(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmcl.2009.03.124
		135398737	958	93	None	-4	89	Rat	8.1	pIC50	=	8.1	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1073/pnas.0611417104
		38	958	93	None	-4	89	Rat	8.1	pIC50	=	8.1	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1073/pnas.0611417104
		722	958	93	None	-4	89	Rat	8.1	pIC50	=	8.1	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1073/pnas.0611417104
		CHEMBL42	958	93	None	-4	89	Rat	8.1	pIC50	=	8.1	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1073/pnas.0611417104
		DB00363	958	93	None	-4	89	Rat	8.1	pIC50	=	8.1	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1073/pnas.0611417104
		1385580	29276	76	None	-	5	Guinea pig	8.1	pIC50	=	8.1	Binding	Inhibitory activity against Tritiated [3H]- mepyramine binding to Histamine H1 receptor in guinea pig cerebral cortexInhibitory activity against Tritiated [3H]- mepyramine binding to Histamine H1 receptor in guinea pig cerebral cortex	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1021/jm00121a022
		4615	29276	76	None	-	5	Guinea pig	8.1	pIC50	=	8.1	Binding	Inhibitory activity against Tritiated [3H]- mepyramine binding to Histamine H1 receptor in guinea pig cerebral cortexInhibitory activity against Tritiated [3H]- mepyramine binding to Histamine H1 receptor in guinea pig cerebral cortex	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1021/jm00121a022
		CHEMBL13828	29276	76	None	-	5	Guinea pig	8.1	pIC50	=	8.1	Binding	Inhibitory activity against Tritiated [3H]- mepyramine binding to Histamine H1 receptor in guinea pig cerebral cortexInhibitory activity against Tritiated [3H]- mepyramine binding to Histamine H1 receptor in guinea pig cerebral cortex	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1021/jm00121a022
		150575506	172171	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	474	6	0	4	6.2	COc1ccccc1OCCCN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/j.bmcl.2019.126712
		CHEMBL4473466	172171	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Antagonist activity at histamine H1 receptor (unknown origin)Antagonist activity at histamine H1 receptor (unknown origin)	ChEMBL	474	6	0	4	6.2	COc1ccccc1OCCCN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/j.bmcl.2019.126712
		6761	67799	19	None	-1	18	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	nan
		CHEMBL1909072	67799	19	None	-1	18	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	nan
		124087	1389	114	None	3	15	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		7157	1389	114	None	3	15	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		814	1389	114	None	3	15	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		CHEMBL1172	1389	114	None	3	15	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		DB00967	1389	114	None	3	15	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		10202996	84642	0	None	-	0	Guinea pig	7.1	pIC50	=	7.1	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	430	6	1	4	5.8	O=C(O)c1cccc(CN2CCC(c3cn(Cc4cccs4)c4ccccc34)CC2)c1	10.1021/jm0498203
		CHEMBL222372	84642	0	None	-	0	Guinea pig	7.1	pIC50	=	7.1	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	430	6	1	4	5.8	O=C(O)c1cccc(CN2CCC(c3cn(Cc4cccs4)c4ccccc34)CC2)c1	10.1021/jm0498203
		10162727	84618	0	None	-	0	Guinea pig	7.0	pIC50	=	7.0	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	478	7	1	5	6.0	COc1ccc(CN2CCC(c3cn(Cc4cccs4)c4cc(F)ccc34)CC2)cc1C(=O)O	10.1021/jm0498203
		CHEMBL222139	84618	0	None	-	0	Guinea pig	7.0	pIC50	=	7.0	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	478	7	1	5	6.0	COc1ccc(CN2CCC(c3cn(Cc4cccs4)c4cc(F)ccc34)CC2)cc1C(=O)O	10.1021/jm0498203
		54580386	62007	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	530	6	1	8	2.6	Cn1c(N2CCCN(CC/C=C3/c4ccccc4COc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmc.2011.03.003
		CHEMBL1774502	62007	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	ChEMBL	530	6	1	8	2.6	Cn1c(N2CCCN(CC/C=C3/c4ccccc4COc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O	10.1016/j.bmc.2011.03.003
		45484995	198519	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptorDisplacement of [3H]pyrilamine from human histamine H1 receptor	ChEMBL	403	6	2	5	3.5	Cc1cnc(N[C@H]2CC[C@@H](CNC(=O)c3ccc(F)c(F)c3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
		CHEMBL577904	198519	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptorDisplacement of [3H]pyrilamine from human histamine H1 receptor	ChEMBL	403	6	2	5	3.5	Cc1cnc(N[C@H]2CC[C@@H](CNC(=O)c3ccc(F)c(F)c3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
		44332030	111488	0	None	-	0	Guinea pig	6.0	pIC50	=	6.0	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	242	0	2	3	1.1	NN1CCN2Cc3[nH]c4ccccc4c3CC2C1	10.1021/jm00173a011
		CHEMBL327724	111488	0	None	-	0	Guinea pig	6.0	pIC50	=	6.0	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	242	0	2	3	1.1	NN1CCN2Cc3[nH]c4ccccc4c3CC2C1	10.1021/jm00173a011
		2600	3779	74	None	-3	13	Guinea pig	7.0	pIC50	=	7.0	Binding	Compound is evaluated for in vitro receptor binding affinity against H1 receptorCompound is evaluated for in vitro receptor binding affinity against H1 receptor	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1021/jm00020a018
		2608	3779	74	None	-3	13	Guinea pig	7.0	pIC50	=	7.0	Binding	Compound is evaluated for in vitro receptor binding affinity against H1 receptorCompound is evaluated for in vitro receptor binding affinity against H1 receptor	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1021/jm00020a018
		5405	3779	74	None	-3	13	Guinea pig	7.0	pIC50	=	7.0	Binding	Compound is evaluated for in vitro receptor binding affinity against H1 receptorCompound is evaluated for in vitro receptor binding affinity against H1 receptor	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1021/jm00020a018
		CHEMBL17157	3779	74	None	-3	13	Guinea pig	7.0	pIC50	=	7.0	Binding	Compound is evaluated for in vitro receptor binding affinity against H1 receptorCompound is evaluated for in vitro receptor binding affinity against H1 receptor	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1021/jm00020a018
		DB00342	3779	74	None	-3	13	Guinea pig	7.0	pIC50	=	7.0	Binding	Compound is evaluated for in vitro receptor binding affinity against H1 receptorCompound is evaluated for in vitro receptor binding affinity against H1 receptor	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1021/jm00020a018
		14407102	13854	0	None	-	0	Guinea pig	6.0	pIC50	=	6.0	Binding	Inhibitory activity against Tritiated [3H]- mepyramine binding to histamine H1 receptor in guinea pig cerebral cortexInhibitory activity against Tritiated [3H]- mepyramine binding to histamine H1 receptor in guinea pig cerebral cortex	ChEMBL	509	10	1	5	5.6	CCOC(=O)c1ccc(OCCCN2CCC(C(O)(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm00121a022
		CHEMBL1195925	13854	0	None	-	0	Guinea pig	6.0	pIC50	=	6.0	Binding	Inhibitory activity against Tritiated [3H]- mepyramine binding to histamine H1 receptor in guinea pig cerebral cortexInhibitory activity against Tritiated [3H]- mepyramine binding to histamine H1 receptor in guinea pig cerebral cortex	ChEMBL	509	10	1	5	5.6	CCOC(=O)c1ccc(OCCCN2CCC(C(O)(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm00121a022
		CHEMBL555593	13854	0	None	-	0	Guinea pig	6.0	pIC50	=	6.0	Binding	Inhibitory activity against Tritiated [3H]- mepyramine binding to histamine H1 receptor in guinea pig cerebral cortexInhibitory activity against Tritiated [3H]- mepyramine binding to histamine H1 receptor in guinea pig cerebral cortex	ChEMBL	509	10	1	5	5.6	CCOC(=O)c1ccc(OCCCN2CCC(C(O)(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm00121a022
		10139591	84640	0	None	-	0	Guinea pig	7.0	pIC50	=	7.0	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	462	7	1	5	5.5	COc1ccc(CN2CCC(c3cn(Cc4ccoc4)c4cc(F)ccc34)CC2)cc1C(=O)O	10.1021/jm0498203
		CHEMBL222356	84640	0	None	-	0	Guinea pig	7.0	pIC50	=	7.0	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	462	7	1	5	5.5	COc1ccc(CN2CCC(c3cn(Cc4ccoc4)c4cc(F)ccc34)CC2)cc1C(=O)O	10.1021/jm0498203
		14762594	111442	3	None	-	0	Guinea pig	6.0	pIC50	=	6.0	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	352	7	1	3	4.0	COc1ccccc1NC(=O)CCN1CCC(Cc2ccccc2)CC1	10.1021/jm00173a011
		CHEMBL327517	111442	3	None	-	0	Guinea pig	6.0	pIC50	=	6.0	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	352	7	1	3	4.0	COc1ccccc1NC(=O)CCN1CCC(Cc2ccccc2)CC1	10.1021/jm00173a011
		11338659	84302	0	None	-	0	Guinea pig	7.0	pIC50	=	7.0	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	404	8	1	4	4.8	C=CCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2ccccc21	10.1021/jm0498203
		CHEMBL221463	84302	0	None	-	0	Guinea pig	7.0	pIC50	=	7.0	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	404	8	1	4	4.8	C=CCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2ccccc21	10.1021/jm0498203
		127049863	140252	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Antagonistic activity at histamine1 receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at histamine1 receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	443	8	1	5	4.5	CNC(=O)c1cc(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)ccc1F	10.1016/j.bmcl.2016.04.087
		CHEMBL3805518	140252	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Antagonistic activity at histamine1 receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at histamine1 receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	443	8	1	5	4.5	CNC(=O)c1cc(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)ccc1F	10.1016/j.bmcl.2016.04.087
		14762596	4373	0	None	-	0	Guinea pig	6.0	pIC50	=	6.0	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	408	4	2	3	3.9	O=C(CCN1CCN2Cc3[nH]c4ccccc4c3CC2C1)Nc1ccccc1Cl	10.1021/jm00173a011
		CHEMBL101217	4373	0	None	-	0	Guinea pig	6.0	pIC50	=	6.0	Binding	Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileumAntihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum	ChEMBL	408	4	2	3	3.9	O=C(CCN1CCN2Cc3[nH]c4ccccc4c3CC2C1)Nc1ccccc1Cl	10.1021/jm00173a011
		10204866	84736	0	None	-	0	Guinea pig	7.0	pIC50	=	7.0	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	460	8	1	5	5.7	O=C(O)c1ccccc1OCCN1CCC(c2cn(Cc3cccs3)c3ccccc23)CC1	10.1021/jm0498203
		CHEMBL222881	84736	0	None	-	0	Guinea pig	7.0	pIC50	=	7.0	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	460	8	1	5	5.7	O=C(O)c1ccccc1OCCN1CCC(c2cn(Cc3cccs3)c3ccccc23)CC1	10.1021/jm0498203
		10138404	136882	0	None	-	0	Guinea pig	7.0	pIC50	=	7.0	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	444	8	1	5	5.2	O=C(O)c1ccccc1OCCN1CCC(c2cn(Cc3ccco3)c3ccccc23)CC1	10.1021/jm0498203
		CHEMBL374218	136882	0	None	-	0	Guinea pig	7.0	pIC50	=	7.0	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	444	8	1	5	5.2	O=C(O)c1ccccc1OCCN1CCC(c2cn(Cc3ccco3)c3ccccc23)CC1	10.1021/jm0498203
		100	3805	58	None	-23	55	Rat	7.0	pIC50	=	7	Binding	Binding affinity against Histamine H1 receptor was measured using radioligand ([3H]pyrilamine) binding assayBinding affinity against Histamine H1 receptor was measured using radioligand ([3H]pyrilamine) binding assay	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00153a010
		2637	3805	58	None	-23	55	Rat	7.0	pIC50	=	7	Binding	Binding affinity against Histamine H1 receptor was measured using radioligand ([3H]pyrilamine) binding assayBinding affinity against Histamine H1 receptor was measured using radioligand ([3H]pyrilamine) binding assay	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00153a010
		5452	3805	58	None	-23	55	Rat	7.0	pIC50	=	7	Binding	Binding affinity against Histamine H1 receptor was measured using radioligand ([3H]pyrilamine) binding assayBinding affinity against Histamine H1 receptor was measured using radioligand ([3H]pyrilamine) binding assay	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00153a010
		CHEMBL479	3805	58	None	-23	55	Rat	7.0	pIC50	=	7	Binding	Binding affinity against Histamine H1 receptor was measured using radioligand ([3H]pyrilamine) binding assayBinding affinity against Histamine H1 receptor was measured using radioligand ([3H]pyrilamine) binding assay	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00153a010
		DB00679	3805	58	None	-23	55	Rat	7.0	pIC50	=	7	Binding	Binding affinity against Histamine H1 receptor was measured using radioligand ([3H]pyrilamine) binding assayBinding affinity against Histamine H1 receptor was measured using radioligand ([3H]pyrilamine) binding assay	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00153a010
		191	403	98	None	-56	29	Human	7.0	pIC50	=	7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		201	403	98	None	-56	29	Human	7.0	pIC50	=	7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		2170	403	98	None	-56	29	Human	7.0	pIC50	=	7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		CHEMBL1113	403	98	None	-56	29	Human	7.0	pIC50	=	7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		DB00543	403	98	None	-56	29	Human	7.0	pIC50	=	7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		135398745	2914	112	None	1	65	Human	10.1	pKd	=	10.1	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm100064d
		47	2914	112	None	1	65	Human	10.1	pKd	=	10.1	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm100064d
		CHEMBL715	2914	112	None	1	65	Human	10.1	pKd	=	10.1	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm100064d
		DB00334	2914	112	None	1	65	Human	10.1	pKd	=	10.1	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm100064d
		CHEMBL5284242	194615	0	None	56	3	Human	10.0	pKd	=	10	Binding	Antagonist potency at human H1 receptorAntagonist potency at human H1 receptor	ChEMBL	510	11	0	6	4.0	COCCCC(=O)N(C)CCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL5315342	194615	0	None	56	3	Human	10.0	pKd	=	10	Binding	Antagonist potency at human H1 receptorAntagonist potency at human H1 receptor	ChEMBL	510	11	0	6	4.0	COCCCC(=O)N(C)CCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		1228	3866	34	None	5	4	Guinea pig	9.9	pKd	=	9.9	Binding	Potency against histamine H1 receptor on guinea pig ileumPotency against histamine H1 receptor on guinea pig ileum	ChEMBL	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	10.1021/jm00017a019
		2763	3866	34	None	5	4	Guinea pig	9.9	pKd	=	9.9	Binding	Potency against histamine H1 receptor on guinea pig ileumPotency against histamine H1 receptor on guinea pig ileum	ChEMBL	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	10.1021/jm00017a019
		5282443	3866	34	None	5	4	Guinea pig	9.9	pKd	=	9.9	Binding	Potency against histamine H1 receptor on guinea pig ileumPotency against histamine H1 receptor on guinea pig ileum	ChEMBL	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	10.1021/jm00017a019
		CHEMBL855	3866	34	None	5	4	Guinea pig	9.9	pKd	=	9.9	Binding	Potency against histamine H1 receptor on guinea pig ileumPotency against histamine H1 receptor on guinea pig ileum	ChEMBL	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	10.1021/jm00017a019
		DB00427	3866	34	None	5	4	Guinea pig	9.9	pKd	=	9.9	Binding	Potency against histamine H1 receptor on guinea pig ileumPotency against histamine H1 receptor on guinea pig ileum	ChEMBL	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	10.1021/jm00017a019
		CHEMBL5275284	194654	0	None	5	3	Human	9.9	pKd	=	9.9	Binding	Antagonist potency at human H1 receptorAntagonist potency at human H1 receptor	ChEMBL	466	8	1	5	3.9	CC(C)C(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL5315872	194654	0	None	5	3	Human	9.9	pKd	=	9.9	Binding	Antagonist potency at human H1 receptorAntagonist potency at human H1 receptor	ChEMBL	466	8	1	5	3.9	CC(C)C(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL5272464	194625	0	None	11	3	Human	9.8	pKd	=	9.8	Binding	Antagonist potency at human H1 receptorAntagonist potency at human H1 receptor	ChEMBL	480	10	1	5	4.4	CCCNC(=O)CCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL5315453	194625	0	None	11	3	Human	9.8	pKd	=	9.8	Binding	Antagonist potency at human H1 receptorAntagonist potency at human H1 receptor	ChEMBL	480	10	1	5	4.4	CCCNC(=O)CCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		24824726	161109	1	None	2	6	Human	9.7	pKd	=	9.7	Binding	Antagonist potency at human H1 receptorAntagonist potency at human H1 receptor	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL4060529	161109	1	None	2	6	Human	9.7	pKd	=	9.7	Binding	Antagonist potency at human H1 receptorAntagonist potency at human H1 receptor	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL4117079	161109	1	None	2	6	Human	9.7	pKd	=	9.7	Binding	Antagonist potency at human H1 receptorAntagonist potency at human H1 receptor	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL5282336	161109	1	None	2	6	Human	9.7	pKd	=	9.7	Binding	Antagonist potency at human H1 receptorAntagonist potency at human H1 receptor	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL5286389	161109	1	None	2	6	Human	9.7	pKd	=	9.7	Binding	Antagonist potency at human H1 receptorAntagonist potency at human H1 receptor	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		2267	559	71	None	10	7	Human	9.7	pKd	=	9.7	Binding	Antagonist potency at human H1 receptorAntagonist potency at human H1 receptor	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1021/acsmedchemlett.7b00112
		271	559	71	None	10	7	Human	9.7	pKd	=	9.7	Binding	Antagonist potency at human H1 receptorAntagonist potency at human H1 receptor	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1021/acsmedchemlett.7b00112
		7121	559	71	None	10	7	Human	9.7	pKd	=	9.7	Binding	Antagonist potency at human H1 receptorAntagonist potency at human H1 receptor	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1021/acsmedchemlett.7b00112
		CHEMBL639	559	71	None	10	7	Human	9.7	pKd	=	9.7	Binding	Antagonist potency at human H1 receptorAntagonist potency at human H1 receptor	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1021/acsmedchemlett.7b00112
		DB00972	559	71	None	10	7	Human	9.7	pKd	=	9.7	Binding	Antagonist potency at human H1 receptorAntagonist potency at human H1 receptor	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1021/acsmedchemlett.7b00112
		CHEMBL5273244	194616	0	None	63	3	Human	9.7	pKd	=	9.7	Binding	Antagonist potency at human H1 receptorAntagonist potency at human H1 receptor	ChEMBL	468	9	1	6	2.9	COCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL5315364	194616	0	None	63	3	Human	9.7	pKd	=	9.7	Binding	Antagonist potency at human H1 receptorAntagonist potency at human H1 receptor	ChEMBL	468	9	1	6	2.9	COCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL5270515	194609	0	None	39	3	Human	9.6	pKd	=	9.6	Binding	Antagonist potency at human H1 receptorAntagonist potency at human H1 receptor	ChEMBL	452	8	1	5	3.6	CCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL5315265	194609	0	None	39	3	Human	9.6	pKd	=	9.6	Binding	Antagonist potency at human H1 receptorAntagonist potency at human H1 receptor	ChEMBL	452	8	1	5	3.6	CCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		1227	2489	43	None	2	12	Guinea pig	9.5	pKd	=	9.5	Binding	Antagonist activity at histamine H1 receptor in Cavia porcellus (guinea pig) ileum assessed as inhibition of electrically-induced contractionAntagonist activity at histamine H1 receptor in Cavia porcellus (guinea pig) ileum assessed as inhibition of electrically-induced contraction	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1007/s00044-012-0090-2
		2331	2489	43	None	2	12	Guinea pig	9.5	pKd	=	9.5	Binding	Antagonist activity at histamine H1 receptor in Cavia porcellus (guinea pig) ileum assessed as inhibition of electrically-induced contractionAntagonist activity at histamine H1 receptor in Cavia porcellus (guinea pig) ileum assessed as inhibition of electrically-induced contraction	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1007/s00044-012-0090-2
		3957	2489	43	None	2	12	Guinea pig	9.5	pKd	=	9.5	Binding	Antagonist activity at histamine H1 receptor in Cavia porcellus (guinea pig) ileum assessed as inhibition of electrically-induced contractionAntagonist activity at histamine H1 receptor in Cavia porcellus (guinea pig) ileum assessed as inhibition of electrically-induced contraction	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1007/s00044-012-0090-2
		4992	2489	43	None	2	12	Guinea pig	9.5	pKd	=	9.5	Binding	Antagonist activity at histamine H1 receptor in Cavia porcellus (guinea pig) ileum assessed as inhibition of electrically-induced contractionAntagonist activity at histamine H1 receptor in Cavia porcellus (guinea pig) ileum assessed as inhibition of electrically-induced contraction	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1007/s00044-012-0090-2
		CHEMBL511	2489	43	None	2	12	Guinea pig	9.5	pKd	=	9.5	Binding	Antagonist activity at histamine H1 receptor in Cavia porcellus (guinea pig) ileum assessed as inhibition of electrically-induced contractionAntagonist activity at histamine H1 receptor in Cavia porcellus (guinea pig) ileum assessed as inhibition of electrically-induced contraction	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1007/s00044-012-0090-2
		DB06691	2489	43	None	2	12	Guinea pig	9.5	pKd	=	9.5	Binding	Antagonist activity at histamine H1 receptor in Cavia porcellus (guinea pig) ileum assessed as inhibition of electrically-induced contractionAntagonist activity at histamine H1 receptor in Cavia porcellus (guinea pig) ileum assessed as inhibition of electrically-induced contraction	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1007/s00044-012-0090-2
		CHEMBL5276489	194643	0	None	70	3	Human	9.5	pKd	=	9.5	Binding	Antagonist potency at human H1 receptorAntagonist potency at human H1 receptor	ChEMBL	492	8	1	5	4.4	O=C(NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O)C1CCCC1	10.1021/acsmedchemlett.7b00112
		CHEMBL5315725	194643	0	None	70	3	Human	9.5	pKd	=	9.5	Binding	Antagonist potency at human H1 receptorAntagonist potency at human H1 receptor	ChEMBL	492	8	1	5	4.4	O=C(NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O)C1CCCC1	10.1021/acsmedchemlett.7b00112
		24824726	161109	1	None	2	6	Human	9.4	pKd	=	9.4	Binding	Antagonist potency at human histamine H1 receptorAntagonist potency at human histamine H1 receptor	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL4060529	161109	1	None	2	6	Human	9.4	pKd	=	9.4	Binding	Antagonist potency at human histamine H1 receptorAntagonist potency at human histamine H1 receptor	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL4117079	161109	1	None	2	6	Human	9.4	pKd	=	9.4	Binding	Antagonist potency at human histamine H1 receptorAntagonist potency at human histamine H1 receptor	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL5282336	161109	1	None	2	6	Human	9.4	pKd	=	9.4	Binding	Antagonist potency at human histamine H1 receptorAntagonist potency at human histamine H1 receptor	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL5286389	161109	1	None	2	6	Human	9.4	pKd	=	9.4	Binding	Antagonist potency at human histamine H1 receptorAntagonist potency at human histamine H1 receptor	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL5272034	194611	0	None	10	3	Human	9.3	pKd	=	9.3	Binding	Antagonist potency at human H1 receptorAntagonist potency at human H1 receptor	ChEMBL	496	11	1	6	3.6	COCCNC(=O)CCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL5315277	194611	0	None	10	3	Human	9.3	pKd	=	9.3	Binding	Antagonist potency at human H1 receptorAntagonist potency at human H1 receptor	ChEMBL	496	11	1	6	3.6	COCCNC(=O)CCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL5286701	194629	0	None	12	3	Human	9.3	pKd	=	9.3	Binding	Antagonist potency at human H1 receptorAntagonist potency at human H1 receptor	ChEMBL	482	10	1	6	3.3	COCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL5315483	194629	0	None	12	3	Human	9.3	pKd	=	9.3	Binding	Antagonist potency at human H1 receptorAntagonist potency at human H1 receptor	ChEMBL	482	10	1	6	3.3	COCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL5269671	194600	0	None	44	3	Human	9.2	pKd	=	9.2	Binding	Antagonist potency at human H1 receptorAntagonist potency at human H1 receptor	ChEMBL	466	9	1	5	4.0	CCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL5315170	194600	0	None	44	3	Human	9.2	pKd	=	9.2	Binding	Antagonist potency at human H1 receptorAntagonist potency at human H1 receptor	ChEMBL	466	9	1	5	4.0	CCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		1227	2489	43	None	2	12	Guinea pig	9.2	pKd	=	9.2	Binding	Antagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 minsAntagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 mins	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1039/C8MD00527C
		2331	2489	43	None	2	12	Guinea pig	9.2	pKd	=	9.2	Binding	Antagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 minsAntagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 mins	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1039/C8MD00527C
		3957	2489	43	None	2	12	Guinea pig	9.2	pKd	=	9.2	Binding	Antagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 minsAntagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 mins	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1039/C8MD00527C
		4992	2489	43	None	2	12	Guinea pig	9.2	pKd	=	9.2	Binding	Antagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 minsAntagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 mins	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1039/C8MD00527C
		CHEMBL511	2489	43	None	2	12	Guinea pig	9.2	pKd	=	9.2	Binding	Antagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 minsAntagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 mins	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1039/C8MD00527C
		DB06691	2489	43	None	2	12	Guinea pig	9.2	pKd	=	9.2	Binding	Antagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 minsAntagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 mins	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1039/C8MD00527C
		CHEMBL5291469	194640	0	None	70	2	Human	9.1	pKd	=	9.1	Binding	Antagonist potency at human H1 receptorAntagonist potency at human H1 receptor	ChEMBL	508	8	1	6	3.6	O=C(NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O)C1CCOCC1	10.1021/acsmedchemlett.7b00112
		CHEMBL5315702	194640	0	None	70	2	Human	9.1	pKd	=	9.1	Binding	Antagonist potency at human H1 receptorAntagonist potency at human H1 receptor	ChEMBL	508	8	1	6	3.6	O=C(NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O)C1CCOCC1	10.1021/acsmedchemlett.7b00112
		277	1301	62	None	2	50	Guinea pig	9.0	pKd	=	9	Binding	Potency against histamine H1 receptor on guinea pig ileumPotency against histamine H1 receptor on guinea pig ileum	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1021/jm00017a019
		2913	1301	62	None	2	50	Guinea pig	9.0	pKd	=	9	Binding	Potency against histamine H1 receptor on guinea pig ileumPotency against histamine H1 receptor on guinea pig ileum	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1021/jm00017a019
		765	1301	62	None	2	50	Guinea pig	9.0	pKd	=	9	Binding	Potency against histamine H1 receptor on guinea pig ileumPotency against histamine H1 receptor on guinea pig ileum	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1021/jm00017a019
		CHEMBL516	1301	62	None	2	50	Guinea pig	9.0	pKd	=	9	Binding	Potency against histamine H1 receptor on guinea pig ileumPotency against histamine H1 receptor on guinea pig ileum	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1021/jm00017a019
		DB00434	1301	62	None	2	50	Guinea pig	9.0	pKd	=	9	Binding	Potency against histamine H1 receptor on guinea pig ileumPotency against histamine H1 receptor on guinea pig ileum	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1021/jm00017a019
		1227	2489	43	None	2	12	Guinea pig	8.8	pKd	=	8.8	Binding	Antagonist activity at histamine H1 receptor in guinea pig jejunum assessed as reduction in histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig jejunum assessed as reduction in histamine-induced contractions	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmcl.2015.02.037
		2331	2489	43	None	2	12	Guinea pig	8.8	pKd	=	8.8	Binding	Antagonist activity at histamine H1 receptor in guinea pig jejunum assessed as reduction in histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig jejunum assessed as reduction in histamine-induced contractions	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmcl.2015.02.037
		3957	2489	43	None	2	12	Guinea pig	8.8	pKd	=	8.8	Binding	Antagonist activity at histamine H1 receptor in guinea pig jejunum assessed as reduction in histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig jejunum assessed as reduction in histamine-induced contractions	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmcl.2015.02.037
		4992	2489	43	None	2	12	Guinea pig	8.8	pKd	=	8.8	Binding	Antagonist activity at histamine H1 receptor in guinea pig jejunum assessed as reduction in histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig jejunum assessed as reduction in histamine-induced contractions	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmcl.2015.02.037
		CHEMBL511	2489	43	None	2	12	Guinea pig	8.8	pKd	=	8.8	Binding	Antagonist activity at histamine H1 receptor in guinea pig jejunum assessed as reduction in histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig jejunum assessed as reduction in histamine-induced contractions	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmcl.2015.02.037
		DB06691	2489	43	None	2	12	Guinea pig	8.8	pKd	=	8.8	Binding	Antagonist activity at histamine H1 receptor in guinea pig jejunum assessed as reduction in histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig jejunum assessed as reduction in histamine-induced contractions	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmcl.2015.02.037
		11291	98796	25	None	4	2	Guinea pig	8.8	pKd	=	8.8	Binding	Potency against histamine H1 receptor on guinea pig ileumPotency against histamine H1 receptor on guinea pig ileum	ChEMBL	261	1	0	1	3.9	CN1CCC2=C(C1)C(c1ccccc1)c1ccccc12	10.1021/jm00017a019
		CHEMBL278398	98796	25	None	4	2	Guinea pig	8.8	pKd	=	8.8	Binding	Potency against histamine H1 receptor on guinea pig ileumPotency against histamine H1 receptor on guinea pig ileum	ChEMBL	261	1	0	1	3.9	CN1CCC2=C(C1)C(c1ccccc1)c1ccccc12	10.1021/jm00017a019
		24824726	161109	1	None	-2	6	Guinea pig	8.7	pKd	=	8.7	Binding	Antagonist activity at histamine H1 receptor in guinea pig isolated trachea assessed as change in histamine-induced contractionAntagonist activity at histamine H1 receptor in guinea pig isolated trachea assessed as change in histamine-induced contraction	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL4060529	161109	1	None	-2	6	Guinea pig	8.7	pKd	=	8.7	Binding	Antagonist activity at histamine H1 receptor in guinea pig isolated trachea assessed as change in histamine-induced contractionAntagonist activity at histamine H1 receptor in guinea pig isolated trachea assessed as change in histamine-induced contraction	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL4117079	161109	1	None	-2	6	Guinea pig	8.7	pKd	=	8.7	Binding	Antagonist activity at histamine H1 receptor in guinea pig isolated trachea assessed as change in histamine-induced contractionAntagonist activity at histamine H1 receptor in guinea pig isolated trachea assessed as change in histamine-induced contraction	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL5282336	161109	1	None	-2	6	Guinea pig	8.7	pKd	=	8.7	Binding	Antagonist activity at histamine H1 receptor in guinea pig isolated trachea assessed as change in histamine-induced contractionAntagonist activity at histamine H1 receptor in guinea pig isolated trachea assessed as change in histamine-induced contraction	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL5286389	161109	1	None	-2	6	Guinea pig	8.7	pKd	=	8.7	Binding	Antagonist activity at histamine H1 receptor in guinea pig isolated trachea assessed as change in histamine-induced contractionAntagonist activity at histamine H1 receptor in guinea pig isolated trachea assessed as change in histamine-induced contraction	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		11097588	202138	2	None	-	1	Guinea pig	8.7	pKd	=	8.7	Binding	Potency against histamine H1 receptor on guinea pig ileumPotency against histamine H1 receptor on guinea pig ileum	ChEMBL	269	6	0	2	3.7	Cc1ccc([C@H](OCCN(C)C)c2ccccc2)cc1	10.1021/jm00017a019
		CHEMBL609131	202138	2	None	-	1	Guinea pig	8.7	pKd	=	8.7	Binding	Potency against histamine H1 receptor on guinea pig ileumPotency against histamine H1 receptor on guinea pig ileum	ChEMBL	269	6	0	2	3.7	Cc1ccc([C@H](OCCN(C)C)c2ccccc2)cc1	10.1021/jm00017a019
		168279703	191138	0	None	-	1	Human	8.0	pKd	=	8	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1372	37	8	13	7.6	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5188259	191138	0	None	-	1	Human	8.0	pKd	=	8	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1372	37	8	13	7.6	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168279703	191138	0	None	-	1	Human	8.0	pKd	=	8.0	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1372	37	8	13	7.6	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5188259	191138	0	None	-	1	Human	8.0	pKd	=	8.0	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1372	37	8	13	7.6	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168282752	191096	0	None	-	1	Human	8.0	pKd	=	8.0	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1303	32	8	13	7.3	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5187728	191096	0	None	-	1	Human	8.0	pKd	=	8.0	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1303	32	8	13	7.3	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		11826604	39706	0	None	-7585	3	Guinea pig	5.0	pKd	=	5	Binding	Activity at Histamine H1 receptor using functional H1 receptor assay on guinea pig ileumActivity at Histamine H1 receptor using functional H1 receptor assay on guinea pig ileum	ChEMBL	457	10	1	4	6.4	c1ccc2c(NCCCc3ccc(OCCCN4CCCCC4)cc3)c3c(nc2c1)CCCC3	10.1021/jm0110845
		CHEMBL14754	39706	0	None	-7585	3	Guinea pig	5.0	pKd	=	5	Binding	Activity at Histamine H1 receptor using functional H1 receptor assay on guinea pig ileumActivity at Histamine H1 receptor using functional H1 receptor assay on guinea pig ileum	ChEMBL	457	10	1	4	6.4	c1ccc2c(NCCCc3ccc(OCCCN4CCCCC4)cc3)c3c(nc2c1)CCCC3	10.1021/jm0110845
		11004759	43164	1	None	-30902	3	Guinea pig	5.0	pKd	=	5	Binding	Activity at Histamine H1 receptor using functional H1 receptor assay on guinea pig ileumActivity at Histamine H1 receptor using functional H1 receptor assay on guinea pig ileum	ChEMBL	443	9	1	4	6.0	c1ccc2c(NCCc3ccc(OCCCN4CCCCC4)cc3)c3c(nc2c1)CCCC3	10.1021/jm0110845
		CHEMBL15056	43164	1	None	-30902	3	Guinea pig	5.0	pKd	=	5	Binding	Activity at Histamine H1 receptor using functional H1 receptor assay on guinea pig ileumActivity at Histamine H1 receptor using functional H1 receptor assay on guinea pig ileum	ChEMBL	443	9	1	4	6.0	c1ccc2c(NCCc3ccc(OCCCN4CCCCC4)cc3)c3c(nc2c1)CCCC3	10.1021/jm0110845
		44352460	20957	0	None	-707	3	Guinea pig	5.0	pKd	=	5	Binding	Receptor profile was evaluated at Histamine H1 receptor of guinea pig ileumReceptor profile was evaluated at Histamine H1 receptor of guinea pig ileum	ChEMBL	238	8	1	2	3.6	CC(C)(C)CCCCOCCCc1c[nH]cn1	10.1021/jm020910m
		CHEMBL131117	20957	0	None	-707	3	Guinea pig	5.0	pKd	=	5	Binding	Receptor profile was evaluated at Histamine H1 receptor of guinea pig ileumReceptor profile was evaluated at Histamine H1 receptor of guinea pig ileum	ChEMBL	238	8	1	2	3.6	CC(C)(C)CCCCOCCCc1c[nH]cn1	10.1021/jm020910m
		155541141	176664	0	None	-2	2	Guinea pig	7.0	pKd	=	7.0	Binding	Antagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 minsAntagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 mins	ChEMBL	504	16	1	5	4.7	N#C/N=C(\N)N(CCCCN1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccccc1	10.1039/C8MD00527C
		CHEMBL4517581	176664	0	None	-2	2	Guinea pig	7.0	pKd	=	7.0	Binding	Antagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 minsAntagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 mins	ChEMBL	504	16	1	5	4.7	N#C/N=C(\N)N(CCCCN1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccccc1	10.1039/C8MD00527C
		CHEMBL4598140	176664	0	None	-2	2	Guinea pig	7.0	pKd	=	7.0	Binding	Antagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 minsAntagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 mins	ChEMBL	504	16	1	5	4.7	N#C/N=C(\N)N(CCCCN1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccccc1	10.1039/C8MD00527C
		168282752	191096	0	None	-	1	Human	8.0	pKd	=	8.0	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1303	32	8	13	7.3	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5187728	191096	0	None	-	1	Human	8.0	pKd	=	8.0	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1303	32	8	13	7.3	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		90667434	109489	0	None	-	1	Guinea pig	6.0	pKd	=	6.0	Binding	Antagonist activity at guinea pig ileum histamine H1 receptor assessed as inhibition of histamine-induced response after 10 to 15 minsAntagonist activity at guinea pig ileum histamine H1 receptor assessed as inhibition of histamine-induced response after 10 to 15 mins	ChEMBL	313	7	2	3	1.9	CC(CC(=O)/N=C(\N)NCCCn1ccnc1)c1ccccc1	10.1039/C3MD00245D
		CHEMBL3220892	109489	0	None	-	1	Guinea pig	6.0	pKd	=	6.0	Binding	Antagonist activity at guinea pig ileum histamine H1 receptor assessed as inhibition of histamine-induced response after 10 to 15 minsAntagonist activity at guinea pig ileum histamine H1 receptor assessed as inhibition of histamine-induced response after 10 to 15 mins	ChEMBL	313	7	2	3	1.9	CC(CC(=O)/N=C(\N)NCCCn1ccnc1)c1ccccc1	10.1039/C3MD00245D
		168288124	191727	0	None	-	1	Human	7.9	pKd	=	7.9	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1259	31	7	12	6.9	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5197183	191727	0	None	-	1	Human	7.9	pKd	=	7.9	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1259	31	7	12	6.9	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168288124	191727	0	None	-	1	Human	7.9	pKd	=	7.9	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1259	31	7	12	6.9	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5197183	191727	0	None	-	1	Human	7.9	pKd	=	7.9	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1259	31	7	12	6.9	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		155540438	172541	0	None	-7	2	Guinea pig	5.9	pKd	=	5.9	Binding	Antagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions after 15 minsAntagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions after 15 mins	ChEMBL	290	3	1	6	1.3	CN1CCN(c2nc(N)nc(CC3CCCCC3)n2)CC1	10.1016/j.bmc.2019.02.020
		CHEMBL4483783	172541	0	None	-7	2	Guinea pig	5.9	pKd	=	5.9	Binding	Antagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions after 15 minsAntagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions after 15 mins	ChEMBL	290	3	1	6	1.3	CN1CCN(c2nc(N)nc(CC3CCCCC3)n2)CC1	10.1016/j.bmc.2019.02.020
		155561756	176416	0	None	-28	2	Guinea pig	6.9	pKd	=	6.9	Binding	Antagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 minsAntagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 mins	ChEMBL	546	16	2	3	7.3	N=C(N)N(CCCCC1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccc(C(F)(F)F)cc1	10.1039/C8MD00527C
		CHEMBL4585110	176416	0	None	-28	2	Guinea pig	6.9	pKd	=	6.9	Binding	Antagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 minsAntagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 mins	ChEMBL	546	16	2	3	7.3	N=C(N)N(CCCCC1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccc(C(F)(F)F)cc1	10.1039/C8MD00527C
		CHEMBL4596105	176416	0	None	-28	2	Guinea pig	6.9	pKd	=	6.9	Binding	Antagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 minsAntagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 mins	ChEMBL	546	16	2	3	7.3	N=C(N)N(CCCCC1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccc(C(F)(F)F)cc1	10.1039/C8MD00527C
		10902522	18976	0	None	-1000	3	Guinea pig	4.9	pKd	=	4.9	Binding	Receptor profile was evaluated at Histamine H1 receptor of guinea pig ileumReceptor profile was evaluated at Histamine H1 receptor of guinea pig ileum	ChEMBL	295	5	2	3	3.5	CC(C)(C)C(NC(=O)OCCCc1c[nH]cn1)C(C)(C)C	10.1021/jm020910m
		CHEMBL128773	18976	0	None	-1000	3	Guinea pig	4.9	pKd	=	4.9	Binding	Receptor profile was evaluated at Histamine H1 receptor of guinea pig ileumReceptor profile was evaluated at Histamine H1 receptor of guinea pig ileum	ChEMBL	295	5	2	3	3.5	CC(C)(C)C(NC(=O)OCCCc1c[nH]cn1)C(C)(C)C	10.1021/jm020910m
		168284216	190877	0	None	-	1	Human	5.9	pKd	=	5.9	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1112	30	9	12	1.8	Cc1cc(C)n2c1C=C1C=CC(CCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CCN3CCC(Oc4ccccc4Cc4ccccc4)CC3)C(C)C)C(N)=O)=[N+]1[B-]2(F)F	10.1021/acs.jmedchem.2c00125
		CHEMBL5184842	190877	0	None	-	1	Human	5.9	pKd	=	5.9	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1112	30	9	12	1.8	Cc1cc(C)n2c1C=C1C=CC(CCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CCN3CCC(Oc4ccccc4Cc4ccccc4)CC3)C(C)C)C(N)=O)=[N+]1[B-]2(F)F	10.1021/acs.jmedchem.2c00125
		168284216	190877	0	None	-	1	Human	5.9	pKd	=	5.9	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1112	30	9	12	1.8	Cc1cc(C)n2c1C=C1C=CC(CCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CCN3CCC(Oc4ccccc4Cc4ccccc4)CC3)C(C)C)C(N)=O)=[N+]1[B-]2(F)F	10.1021/acs.jmedchem.2c00125
		CHEMBL5184842	190877	0	None	-	1	Human	5.9	pKd	=	5.9	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1112	30	9	12	1.8	Cc1cc(C)n2c1C=C1C=CC(CCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CCN3CCC(Oc4ccccc4Cc4ccccc4)CC3)C(C)C)C(N)=O)=[N+]1[B-]2(F)F	10.1021/acs.jmedchem.2c00125
		168269144	189998	0	None	-	1	Human	7.9	pKd	=	7.9	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1193	28	6	14	6.0	C[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCC(=O)N[C@@H](CCCn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5171227	189998	0	None	-	1	Human	7.9	pKd	=	7.9	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1193	28	6	14	6.0	C[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCC(=O)N[C@@H](CCCn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O	10.1021/acs.jmedchem.2c00125
		25149335	184225	0	None	-	1	Guinea pig	5.9	pKd	=	5.9	Binding	Antagonist activity at guinea pig ileum histamine H1 receptor assessed as inhibition of histamine-induced response after 10 to 15 minsAntagonist activity at guinea pig ileum histamine H1 receptor assessed as inhibition of histamine-induced response after 10 to 15 mins	ChEMBL	313	7	3	2	2.0	CC(CC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1039/C3MD00245D
		CHEMBL483406	184225	0	None	-	1	Guinea pig	5.9	pKd	=	5.9	Binding	Antagonist activity at guinea pig ileum histamine H1 receptor assessed as inhibition of histamine-induced response after 10 to 15 minsAntagonist activity at guinea pig ileum histamine H1 receptor assessed as inhibition of histamine-induced response after 10 to 15 mins	ChEMBL	313	7	3	2	2.0	CC(CC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1039/C3MD00245D
		168269144	189998	0	None	-	1	Human	7.9	pKd	=	7.9	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1193	28	6	14	6.0	C[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCC(=O)N[C@@H](CCCn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5171227	189998	0	None	-	1	Human	7.9	pKd	=	7.9	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1193	28	6	14	6.0	C[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCC(=O)N[C@@H](CCCn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168282405	191207	0	None	-	1	Human	5.8	pKd	=	5.8	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1101	28	7	10	4.5	Cc1cc(C)n2c1C=C1C=CC(CCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCN3CCC(Oc4ccccc4Cc4ccccc4)CC3)C(N)=O)=[N+]1[B-]2(F)F	10.1021/acs.jmedchem.2c00125
		CHEMBL5189492	191207	0	None	-	1	Human	5.8	pKd	=	5.8	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1101	28	7	10	4.5	Cc1cc(C)n2c1C=C1C=CC(CCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCN3CCC(Oc4ccccc4Cc4ccccc4)CC3)C(N)=O)=[N+]1[B-]2(F)F	10.1021/acs.jmedchem.2c00125
		168282405	191207	0	None	-	1	Human	5.8	pKd	=	5.8	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1101	28	7	10	4.5	Cc1cc(C)n2c1C=C1C=CC(CCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCN3CCC(Oc4ccccc4Cc4ccccc4)CC3)C(N)=O)=[N+]1[B-]2(F)F	10.1021/acs.jmedchem.2c00125
		CHEMBL5189492	191207	0	None	-	1	Human	5.8	pKd	=	5.8	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1101	28	7	10	4.5	Cc1cc(C)n2c1C=C1C=CC(CCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCN3CCC(Oc4ccccc4Cc4ccccc4)CC3)C(N)=O)=[N+]1[B-]2(F)F	10.1021/acs.jmedchem.2c00125
		90667234	109473	0	None	-	1	Guinea pig	5.8	pKd	=	5.8	Binding	Antagonist activity at guinea pig ileum histamine H1 receptor assessed as inhibition of histamine-induced response after 10 to 15 minsAntagonist activity at guinea pig ileum histamine H1 receptor assessed as inhibition of histamine-induced response after 10 to 15 mins	ChEMBL	314	7	3	3	1.4	CC(CC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1039/C3MD00245D
		CHEMBL3220635	109473	0	None	-	1	Guinea pig	5.8	pKd	=	5.8	Binding	Antagonist activity at guinea pig ileum histamine H1 receptor assessed as inhibition of histamine-induced response after 10 to 15 minsAntagonist activity at guinea pig ileum histamine H1 receptor assessed as inhibition of histamine-induced response after 10 to 15 mins	ChEMBL	314	7	3	3	1.4	CC(CC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1039/C3MD00245D
		168281594	191269	0	None	-	1	Human	7.8	pKd	=	7.8	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1319	33	9	14	6.2	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5190566	191269	0	None	-	1	Human	7.8	pKd	=	7.8	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1319	33	9	14	6.2	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		102596130	117699	21	None	-	1	Guinea pig	6.8	pKd	=	6.8	Binding	Antagonist activity at histamine H1 receptor in guinea pig jejunum assessed as reduction in histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig jejunum assessed as reduction in histamine-induced contractions	ChEMBL	405	0	0	5	4.0	O=C(N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1)n1cncn1	10.1016/j.bmcl.2015.02.037
		CHEMBL3401455	117699	21	None	-	1	Guinea pig	6.8	pKd	=	6.8	Binding	Antagonist activity at histamine H1 receptor in guinea pig jejunum assessed as reduction in histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig jejunum assessed as reduction in histamine-induced contractions	ChEMBL	405	0	0	5	4.0	O=C(N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1)n1cncn1	10.1016/j.bmcl.2015.02.037
		155554852	176612	0	None	10	2	Guinea pig	6.8	pKd	=	6.8	Binding	Antagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 minsAntagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 mins	ChEMBL	339	11	2	2	4.4	N=C(N)N(CCCCCCCOc1ccccc1)Cc1ccccc1	10.1039/C8MD00527C
		CHEMBL4550675	176612	0	None	10	2	Guinea pig	6.8	pKd	=	6.8	Binding	Antagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 minsAntagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 mins	ChEMBL	339	11	2	2	4.4	N=C(N)N(CCCCCCCOc1ccccc1)Cc1ccccc1	10.1039/C8MD00527C
		CHEMBL4597766	176612	0	None	10	2	Guinea pig	6.8	pKd	=	6.8	Binding	Antagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 minsAntagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 mins	ChEMBL	339	11	2	2	4.4	N=C(N)N(CCCCCCCOc1ccccc1)Cc1ccccc1	10.1039/C8MD00527C
		11437142	202606	2	None	-	1	Guinea pig	6.8	pKd	=	6.8	Binding	Potency against histamine H1 receptor on guinea pig ileumPotency against histamine H1 receptor on guinea pig ileum	ChEMBL	269	6	0	2	3.7	Cc1ccc([C@@H](OCCN(C)C)c2ccccc2)cc1	10.1021/jm00017a019
		CHEMBL612084	202606	2	None	-	1	Guinea pig	6.8	pKd	=	6.8	Binding	Potency against histamine H1 receptor on guinea pig ileumPotency against histamine H1 receptor on guinea pig ileum	ChEMBL	269	6	0	2	3.7	Cc1ccc([C@@H](OCCN(C)C)c2ccccc2)cc1	10.1021/jm00017a019
		168281594	191269	0	None	-	1	Human	7.8	pKd	=	7.8	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1319	33	9	14	6.2	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5190566	191269	0	None	-	1	Human	7.8	pKd	=	7.8	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1319	33	9	14	6.2	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168297910	192453	0	None	-	1	Human	6.8	pKd	=	6.8	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1223	29	7	15	5.0	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5208512	192453	0	None	-	1	Human	6.8	pKd	=	6.8	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1223	29	7	15	5.0	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168297910	192453	0	None	-	1	Human	6.8	pKd	=	6.8	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1223	29	7	15	5.0	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5208512	192453	0	None	-	1	Human	6.8	pKd	=	6.8	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1223	29	7	15	5.0	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O	10.1021/acs.jmedchem.2c00125
		90667235	109474	0	None	-	1	Guinea pig	5.8	pKd	=	5.8	Binding	Antagonist activity at guinea pig ileum histamine H1 receptor assessed as inhibition of histamine-induced response after 10 to 15 minsAntagonist activity at guinea pig ileum histamine H1 receptor assessed as inhibition of histamine-induced response after 10 to 15 mins	ChEMBL	376	8	3	3	2.4	N/C(=N\C(=O)CC(c1ccccc1)c1ccccc1)NCCCc1ncn[nH]1	10.1039/C3MD00245D
		CHEMBL3220636	109474	0	None	-	1	Guinea pig	5.8	pKd	=	5.8	Binding	Antagonist activity at guinea pig ileum histamine H1 receptor assessed as inhibition of histamine-induced response after 10 to 15 minsAntagonist activity at guinea pig ileum histamine H1 receptor assessed as inhibition of histamine-induced response after 10 to 15 mins	ChEMBL	376	8	3	3	2.4	N/C(=N\C(=O)CC(c1ccccc1)c1ccccc1)NCCCc1ncn[nH]1	10.1039/C3MD00245D
		168280897	190786	0	None	-	1	Human	7.8	pKd	=	7.8	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1383	39	10	15	4.9	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5183511	190786	0	None	-	1	Human	7.8	pKd	=	7.8	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1383	39	10	15	4.9	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168280897	190786	0	None	-	1	Human	7.7	pKd	=	7.7	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1383	39	10	15	4.9	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5183511	190786	0	None	-	1	Human	7.7	pKd	=	7.7	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1383	39	10	15	4.9	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168285825	191547	0	None	-	1	Human	7.7	pKd	=	7.7	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1278	31	8	16	4.7	CC(C)[C@H](NC(=O)CCN(C)CC/C=C1\c2ccccc2COc2ccccc21)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5194541	191547	0	None	-	1	Human	7.7	pKd	=	7.7	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1278	31	8	16	4.7	CC(C)[C@H](NC(=O)CCN(C)CC/C=C1\c2ccccc2COc2ccccc21)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168285825	191547	0	None	-	1	Human	7.7	pKd	=	7.7	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1278	31	8	16	4.7	CC(C)[C@H](NC(=O)CCN(C)CC/C=C1\c2ccccc2COc2ccccc21)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5194541	191547	0	None	-	1	Human	7.7	pKd	=	7.7	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1278	31	8	16	4.7	CC(C)[C@H](NC(=O)CCN(C)CC/C=C1\c2ccccc2COc2ccccc21)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168280529	190784	0	None	-	1	Human	7.7	pKd	=	7.7	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1280	32	8	16	4.5	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5183487	190784	0	None	-	1	Human	7.7	pKd	=	7.7	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1280	32	8	16	4.5	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168292310	191974	0	None	-	1	Human	7.7	pKd	=	7.7	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1093	23	5	13	5.7	C[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5201153	191974	0	None	-	1	Human	7.7	pKd	=	7.7	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1093	23	5	13	5.7	C[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O	10.1021/acs.jmedchem.2c00125
		1605	2342	117	None	-2	4	Human	6.7	pKd	=	6.7	Binding	Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayBinding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assay	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1021/acs.jmedchem.0c00483
		3957	2342	117	None	-2	4	Human	6.7	pKd	=	6.7	Binding	Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayBinding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assay	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1021/acs.jmedchem.0c00483
		7216	2342	117	None	-2	4	Human	6.7	pKd	=	6.7	Binding	Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayBinding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assay	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1021/acs.jmedchem.0c00483
		CHEMBL998	2342	117	None	-2	4	Human	6.7	pKd	=	6.7	Binding	Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayBinding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assay	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1021/acs.jmedchem.0c00483
		DB00455	2342	117	None	-2	4	Human	6.7	pKd	=	6.7	Binding	Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayBinding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assay	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1021/acs.jmedchem.0c00483
		4161540	116089	26	None	-	1	Human	6.7	pKd	=	6.7	Binding	Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayBinding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assay	ChEMBL	412	2	1	4	4.4	CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3c(CO)ccnc32)CC1	10.1021/acs.jmedchem.0c00483
		CHEMBL3357022	116089	26	None	-	1	Human	6.7	pKd	=	6.7	Binding	Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayBinding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assay	ChEMBL	412	2	1	4	4.4	CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3c(CO)ccnc32)CC1	10.1021/acs.jmedchem.0c00483
		60150162	173866	0	None	-32	5	Guinea pig	6.7	pKd	=	6.7	Binding	Antagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 5 mins followed by histamine addition during 30 mins equilibration period with washing every 10 minsAntagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 5 mins followed by histamine addition during 30 mins equilibration period with washing every 10 mins	ChEMBL	479	16	2	4	4.8	N=C(N)N(CCCCN1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccccc1	10.1039/C8MD00527C
		CHEMBL4539444	173866	0	None	-32	5	Guinea pig	6.7	pKd	=	6.7	Binding	Antagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 5 mins followed by histamine addition during 30 mins equilibration period with washing every 10 minsAntagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 5 mins followed by histamine addition during 30 mins equilibration period with washing every 10 mins	ChEMBL	479	16	2	4	4.8	N=C(N)N(CCCCN1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccccc1	10.1039/C8MD00527C
		10933521	163465	0	None	-100	3	Guinea pig	5.7	pKd	=	5.7	Binding	Receptor profile was evaluated at Histamine H1 receptor of guinea pig ileumReceptor profile was evaluated at Histamine H1 receptor of guinea pig ileum	ChEMBL	237	6	2	3	1.9	CC(NC(=O)OCCCc1c[nH]cn1)C1CC1	10.1021/jm020910m
		CHEMBL419975	163465	0	None	-100	3	Guinea pig	5.7	pKd	=	5.7	Binding	Receptor profile was evaluated at Histamine H1 receptor of guinea pig ileumReceptor profile was evaluated at Histamine H1 receptor of guinea pig ileum	ChEMBL	237	6	2	3	1.9	CC(NC(=O)OCCCc1c[nH]cn1)C1CC1	10.1021/jm020910m
		10977121	20784	2	None	-3715	3	Guinea pig	4.7	pKd	=	4.7	Binding	Receptor profile was evaluated at Histamine H1 receptor of guinea pig ileumReceptor profile was evaluated at Histamine H1 receptor of guinea pig ileum	ChEMBL	224	7	1	2	3.2	CC(C)(C)CCCOCCCc1c[nH]cn1	10.1021/jm020910m
		CHEMBL130958	20784	2	None	-3715	3	Guinea pig	4.7	pKd	=	4.7	Binding	Receptor profile was evaluated at Histamine H1 receptor of guinea pig ileumReceptor profile was evaluated at Histamine H1 receptor of guinea pig ileum	ChEMBL	224	7	1	2	3.2	CC(C)(C)CCCOCCCc1c[nH]cn1	10.1021/jm020910m
		168280529	190784	0	None	-	1	Human	7.7	pKd	=	7.7	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1280	32	8	16	4.5	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5183487	190784	0	None	-	1	Human	7.7	pKd	=	7.7	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1280	32	8	16	4.5	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168292310	191974	0	None	-	1	Human	7.7	pKd	=	7.7	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1093	23	5	13	5.7	C[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5201153	191974	0	None	-	1	Human	7.7	pKd	=	7.7	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1093	23	5	13	5.7	C[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O	10.1021/acs.jmedchem.2c00125
		12884174	177738	2	None	-	1	Human	6.7	pKd	=	6.7	Binding	Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayBinding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assay	ChEMBL	348	1	0	3	4.2	CCOC(=O)N1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1021/acs.jmedchem.0c00483
		CHEMBL4642460	177738	2	None	-	1	Human	6.7	pKd	=	6.7	Binding	Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayBinding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assay	ChEMBL	348	1	0	3	4.2	CCOC(=O)N1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1021/acs.jmedchem.0c00483
		168269973	189926	0	None	-	1	Human	6.7	pKd	=	6.7	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1166	31	9	13	2.9	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCC1=[N+]2C(=Cc3ccc(-c4cccs4)n3[B-]2(F)F)C=C1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5169978	189926	0	None	-	1	Human	6.7	pKd	=	6.7	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1166	31	9	13	2.9	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCC1=[N+]2C(=Cc3ccc(-c4cccs4)n3[B-]2(F)F)C=C1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168269973	189926	0	None	-	1	Human	6.7	pKd	=	6.7	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1166	31	9	13	2.9	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCC1=[N+]2C(=Cc3ccc(-c4cccs4)n3[B-]2(F)F)C=C1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5169978	189926	0	None	-	1	Human	6.7	pKd	=	6.7	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1166	31	9	13	2.9	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCC1=[N+]2C(=Cc3ccc(-c4cccs4)n3[B-]2(F)F)C=C1)C(N)=O	10.1021/acs.jmedchem.2c00125
		6604035	168075	6	None	-	1	Guinea pig	6.7	pKd	=	6.7	Binding	Inhibition of specific binding of [3H]mepyramine to Histamine 1 receptors in guinea-pigInhibition of specific binding of [3H]mepyramine to Histamine 1 receptors in guinea-pig	ChEMBL	471	8	2	3	6.4	CC(C)(C)c1ccc([C@@H](O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1	10.1016/S0960-894X(00)80261-9
		CHEMBL432527	168075	6	None	-	1	Guinea pig	6.7	pKd	=	6.7	Binding	Inhibition of specific binding of [3H]mepyramine to Histamine 1 receptors in guinea-pigInhibition of specific binding of [3H]mepyramine to Histamine 1 receptors in guinea-pig	ChEMBL	471	8	2	3	6.4	CC(C)(C)c1ccc([C@@H](O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1	10.1016/S0960-894X(00)80261-9
		168280244	190971	0	None	-	1	Human	5.7	pKd	=	5.7	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1462	38	10	17	4.5	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCCCC[N+]1=C(/C=C/C=C/C=C2/N(C)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5186049	190971	0	None	-	1	Human	5.7	pKd	=	5.7	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1462	38	10	17	4.5	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCCCC[N+]1=C(/C=C/C=C/C=C2/N(C)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(N)=O	10.1021/acs.jmedchem.2c00125
		168284928	191384	0	None	-	1	Human	5.7	pKd	=	5.7	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1451	36	8	15	7.2	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCCCC[N+]1=C(/C=C/C=C/C=C2/N(C)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5192377	191384	0	None	-	1	Human	5.7	pKd	=	5.7	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1451	36	8	15	7.2	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCCCC[N+]1=C(/C=C/C=C/C=C2/N(C)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(N)=O	10.1021/acs.jmedchem.2c00125
		168280244	190971	0	None	-	1	Human	5.7	pKd	=	5.7	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1462	38	10	17	4.5	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCCCC[N+]1=C(/C=C/C=C/C=C2/N(C)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5186049	190971	0	None	-	1	Human	5.7	pKd	=	5.7	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1462	38	10	17	4.5	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCCCC[N+]1=C(/C=C/C=C/C=C2/N(C)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(N)=O	10.1021/acs.jmedchem.2c00125
		168284928	191384	0	None	-	1	Human	5.7	pKd	=	5.7	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1451	36	8	15	7.2	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCCCC[N+]1=C(/C=C/C=C/C=C2/N(C)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5192377	191384	0	None	-	1	Human	5.7	pKd	=	5.7	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1451	36	8	15	7.2	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCCCC[N+]1=C(/C=C/C=C/C=C2/N(C)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(N)=O	10.1021/acs.jmedchem.2c00125
		60150166	174724	0	None	-60	5	Guinea pig	6.7	pKd	=	6.7	Binding	Antagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 5 mins followed by histamine addition during 30 mins equilibration period with washing every 10 minsAntagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 5 mins followed by histamine addition during 30 mins equilibration period with washing every 10 mins	ChEMBL	524	17	2	6	4.7	N=C(N)N(CCCCN1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccc([N+](=O)[O-])cc1	10.1039/C8MD00527C
		CHEMBL4560123	174724	0	None	-60	5	Guinea pig	6.7	pKd	=	6.7	Binding	Antagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 5 mins followed by histamine addition during 30 mins equilibration period with washing every 10 minsAntagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 5 mins followed by histamine addition during 30 mins equilibration period with washing every 10 mins	ChEMBL	524	17	2	6	4.7	N=C(N)N(CCCCN1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccc([N+](=O)[O-])cc1	10.1039/C8MD00527C
		156012610	177394	0	None	-	1	Human	6.6	pKd	=	6.6	Binding	Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayBinding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assay	ChEMBL	400	1	0	3	5.4	CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CC(F)c3cccnc32)CC1	10.1021/acs.jmedchem.0c00483
		CHEMBL4638183	177394	0	None	-	1	Human	6.6	pKd	=	6.6	Binding	Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayBinding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assay	ChEMBL	400	1	0	3	5.4	CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CC(F)c3cccnc32)CC1	10.1021/acs.jmedchem.0c00483
		90667227	109468	0	None	-	1	Guinea pig	5.6	pKd	=	5.6	Binding	Antagonist activity at guinea pig ileum histamine H1 receptor assessed as inhibition of histamine-induced response after 10 to 15 minsAntagonist activity at guinea pig ileum histamine H1 receptor assessed as inhibition of histamine-induced response after 10 to 15 mins	ChEMBL	375	8	2	3	2.9	N/C(=N\C(=O)CC(c1ccccc1)c1ccccc1)NCCCn1ccnc1	10.1039/C3MD00245D
		CHEMBL3220628	109468	0	None	-	1	Guinea pig	5.6	pKd	=	5.6	Binding	Antagonist activity at guinea pig ileum histamine H1 receptor assessed as inhibition of histamine-induced response after 10 to 15 minsAntagonist activity at guinea pig ileum histamine H1 receptor assessed as inhibition of histamine-induced response after 10 to 15 mins	ChEMBL	375	8	2	3	2.9	N/C(=N\C(=O)CC(c1ccccc1)c1ccccc1)NCCCn1ccnc1	10.1039/C3MD00245D
		155540201	172908	0	None	-15	5	Guinea pig	6.6	pKd	=	6.6	Binding	Antagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 5 mins followed by histamine addition during 30 mins equilibration period with washing every 10 minsAntagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 5 mins followed by histamine addition during 30 mins equilibration period with washing every 10 mins	ChEMBL	513	16	2	4	5.5	N=C(N)N(CCCCN1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccc(Cl)cc1	10.1039/C8MD00527C
		CHEMBL4516173	172908	0	None	-15	5	Guinea pig	6.6	pKd	=	6.6	Binding	Antagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 5 mins followed by histamine addition during 30 mins equilibration period with washing every 10 minsAntagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 5 mins followed by histamine addition during 30 mins equilibration period with washing every 10 mins	ChEMBL	513	16	2	4	5.5	N=C(N)N(CCCCN1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccc(Cl)cc1	10.1039/C8MD00527C
		124087	1389	114	None	3	15	Human	7.6	pKd	=	7.6	Binding	Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayBinding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assay	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1021/acs.jmedchem.0c00483
		7157	1389	114	None	3	15	Human	7.6	pKd	=	7.6	Binding	Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayBinding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assay	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1021/acs.jmedchem.0c00483
		814	1389	114	None	3	15	Human	7.6	pKd	=	7.6	Binding	Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayBinding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assay	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1021/acs.jmedchem.0c00483
		CHEMBL1172	1389	114	None	3	15	Human	7.6	pKd	=	7.6	Binding	Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayBinding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assay	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1021/acs.jmedchem.0c00483
		DB00967	1389	114	None	3	15	Human	7.6	pKd	=	7.6	Binding	Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayBinding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assay	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1021/acs.jmedchem.0c00483
		10916261	35292	0	None	-30902	3	Guinea pig	5.6	pKd	=	5.6	Binding	Activity at Histamine H1 receptor using functional H1 receptor assay on guinea pig ileumActivity at Histamine H1 receptor using functional H1 receptor assay on guinea pig ileum	ChEMBL	395	7	1	4	5.9	Clc1ccc2c(Nc3ccc(OCCCN4CCCCC4)cc3)ccnc2c1	10.1021/jm0110845
		CHEMBL14364	35292	0	None	-30902	3	Guinea pig	5.6	pKd	=	5.6	Binding	Activity at Histamine H1 receptor using functional H1 receptor assay on guinea pig ileumActivity at Histamine H1 receptor using functional H1 receptor assay on guinea pig ileum	ChEMBL	395	7	1	4	5.9	Clc1ccc2c(Nc3ccc(OCCCN4CCCCC4)cc3)ccnc2c1	10.1021/jm0110845
		9794557	19999	0	None	-83	3	Guinea pig	4.6	pKd	=	4.6	Binding	Receptor profile was evaluated at Histamine H1 receptor of guinea pig ileumReceptor profile was evaluated at Histamine H1 receptor of guinea pig ileum	ChEMBL	227	6	0	2	3.3	CC(C)(C)CCOCCCN1CCCCC1	10.1021/jm020910m
		CHEMBL130331	19999	0	None	-83	3	Guinea pig	4.6	pKd	=	4.6	Binding	Receptor profile was evaluated at Histamine H1 receptor of guinea pig ileumReceptor profile was evaluated at Histamine H1 receptor of guinea pig ileum	ChEMBL	227	6	0	2	3.3	CC(C)(C)CCOCCCN1CCCCC1	10.1021/jm020910m
		156013234	177503	0	None	-	1	Human	6.6	pKd	=	6.6	Binding	Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayBinding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assay	ChEMBL	398	1	1	4	4.4	CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3C(O)Cc3cccnc32)CC1	10.1021/acs.jmedchem.0c00483
		CHEMBL4639563	177503	0	None	-	1	Human	6.6	pKd	=	6.6	Binding	Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayBinding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assay	ChEMBL	398	1	1	4	4.4	CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3C(O)Cc3cccnc32)CC1	10.1021/acs.jmedchem.0c00483
		90667233	109472	0	None	-	1	Guinea pig	5.6	pKd	=	5.6	Binding	Antagonist activity at guinea pig ileum histamine H1 receptor assessed as inhibition of histamine-induced response after 10 to 15 minsAntagonist activity at guinea pig ileum histamine H1 receptor assessed as inhibition of histamine-induced response after 10 to 15 mins	ChEMBL	375	8	3	2	3.0	N/C(=N\C(=O)CC(c1ccccc1)c1ccccc1)NCCCc1cn[nH]c1	10.1039/C3MD00245D
		CHEMBL3220634	109472	0	None	-	1	Guinea pig	5.6	pKd	=	5.6	Binding	Antagonist activity at guinea pig ileum histamine H1 receptor assessed as inhibition of histamine-induced response after 10 to 15 minsAntagonist activity at guinea pig ileum histamine H1 receptor assessed as inhibition of histamine-induced response after 10 to 15 mins	ChEMBL	375	8	3	2	3.0	N/C(=N\C(=O)CC(c1ccccc1)c1ccccc1)NCCCc1cn[nH]c1	10.1039/C3MD00245D
		168281433	190959	0	None	-	1	Human	5.6	pKd	=	5.6	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1214	34	8	11	5.2	Cc1cc(C)n2c1C=C1C=CC(CCC(=O)NCCCCCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCN3CCC(Oc4ccccc4Cc4ccccc4)CC3)C(N)=O)=[N+]1[B-]2(F)F	10.1021/acs.jmedchem.2c00125
		CHEMBL5185960	190959	0	None	-	1	Human	5.6	pKd	=	5.6	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1214	34	8	11	5.2	Cc1cc(C)n2c1C=C1C=CC(CCC(=O)NCCCCCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCN3CCC(Oc4ccccc4Cc4ccccc4)CC3)C(N)=O)=[N+]1[B-]2(F)F	10.1021/acs.jmedchem.2c00125
		168281433	190959	0	None	-	1	Human	5.6	pKd	=	5.6	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1214	34	8	11	5.2	Cc1cc(C)n2c1C=C1C=CC(CCC(=O)NCCCCCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCN3CCC(Oc4ccccc4Cc4ccccc4)CC3)C(N)=O)=[N+]1[B-]2(F)F	10.1021/acs.jmedchem.2c00125
		CHEMBL5185960	190959	0	None	-	1	Human	5.6	pKd	=	5.6	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1214	34	8	11	5.2	Cc1cc(C)n2c1C=C1C=CC(CCC(=O)NCCCCCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCN3CCC(Oc4ccccc4Cc4ccccc4)CC3)C(N)=O)=[N+]1[B-]2(F)F	10.1021/acs.jmedchem.2c00125
		156010880	177143	0	None	-	1	Human	6.6	pKd	=	6.6	Binding	Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayBinding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assay	ChEMBL	432	2	0	3	5.8	CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3c(C(F)F)ccnc32)CC1	10.1021/acs.jmedchem.0c00483
		CHEMBL4633975	177143	0	None	-	1	Human	6.6	pKd	=	6.6	Binding	Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayBinding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assay	ChEMBL	432	2	0	3	5.8	CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3c(C(F)F)ccnc32)CC1	10.1021/acs.jmedchem.0c00483
		168290008	191817	0	None	-	1	Human	7.6	pKd	=	7.6	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1180	27	7	15	4.2	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5198557	191817	0	None	-	1	Human	7.6	pKd	=	7.6	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1180	27	7	15	4.2	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O	10.1021/acs.jmedchem.2c00125
		14637775	178038	25	None	-	1	Human	7.6	pKd	=	7.6	Binding	Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayBinding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assay	ChEMBL	326	0	2	3	3.5	OC1Cc2cc(Cl)ccc2C(=C2CCNCC2)c2ncccc21	10.1021/acs.jmedchem.0c00483
		CHEMBL4647038	178038	25	None	-	1	Human	7.6	pKd	=	7.6	Binding	Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayBinding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assay	ChEMBL	326	0	2	3	3.5	OC1Cc2cc(Cl)ccc2C(=C2CCNCC2)c2ncccc21	10.1021/acs.jmedchem.0c00483
		168290008	191817	0	None	-	1	Human	7.6	pKd	=	7.6	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1180	27	7	15	4.2	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5198557	191817	0	None	-	1	Human	7.6	pKd	=	7.6	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1180	27	7	15	4.2	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O	10.1021/acs.jmedchem.2c00125
		155550732	176629	0	None	-11	3	Guinea pig	6.5	pKd	=	6.5	Binding	Antagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions incubated for 15 minsAntagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions incubated for 15 mins	ChEMBL	323	8	0	2	5.4	c1ccc(-c2ccc(OCCCCCN3CCCCC3)cc2)cc1	10.1016/j.bmc.2017.07.058
		CHEMBL4540849	176629	0	None	-11	3	Guinea pig	6.5	pKd	=	6.5	Binding	Antagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions incubated for 15 minsAntagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions incubated for 15 mins	ChEMBL	323	8	0	2	5.4	c1ccc(-c2ccc(OCCCCCN3CCCCC3)cc2)cc1	10.1016/j.bmc.2017.07.058
		CHEMBL4597895	176629	0	None	-11	3	Guinea pig	6.5	pKd	=	6.5	Binding	Antagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions incubated for 15 minsAntagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions incubated for 15 mins	ChEMBL	323	8	0	2	5.4	c1ccc(-c2ccc(OCCCCCN3CCCCC3)cc2)cc1	10.1016/j.bmc.2017.07.058
		135398737	958	93	None	2	89	Human	8.5	pKd	=	8.5	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm100064d
		38	958	93	None	2	89	Human	8.5	pKd	=	8.5	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm100064d
		722	958	93	None	2	89	Human	8.5	pKd	=	8.5	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm100064d
		CHEMBL42	958	93	None	2	89	Human	8.5	pKd	=	8.5	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm100064d
		DB00363	958	93	None	2	89	Human	8.5	pKd	=	8.5	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm100064d
		168280938	190830	0	None	-	1	Human	8.4	pKd	=	8.4	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1270	33	9	14	4.2	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5184108	190830	0	None	-	1	Human	8.4	pKd	=	8.4	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1270	33	9	14	4.2	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		90667430	109488	0	None	-	1	Guinea pig	5.5	pKd	=	5.5	Binding	Antagonist activity at guinea pig ileum histamine H1 receptor assessed as inhibition of histamine-induced response after 10 to 15 minsAntagonist activity at guinea pig ileum histamine H1 receptor assessed as inhibition of histamine-induced response after 10 to 15 mins	ChEMBL	370	9	2	3	2.9	CC(CC(=O)/N=C(\N)NCCCc1ccc(CN(C)C)o1)c1ccccc1	10.1039/C3MD00245D
		CHEMBL3220888	109488	0	None	-	1	Guinea pig	5.5	pKd	=	5.5	Binding	Antagonist activity at guinea pig ileum histamine H1 receptor assessed as inhibition of histamine-induced response after 10 to 15 minsAntagonist activity at guinea pig ileum histamine H1 receptor assessed as inhibition of histamine-induced response after 10 to 15 mins	ChEMBL	370	9	2	3	2.9	CC(CC(=O)/N=C(\N)NCCCc1ccc(CN(C)C)o1)c1ccccc1	10.1039/C3MD00245D
		2600	3779	74	None	-3	13	Guinea pig	6.5	pKd	=	6.5	Binding	Inhibition of specific binding of [3H]mepyramine to Histamine 1 receptors in guinea-pigInhibition of specific binding of [3H]mepyramine to Histamine 1 receptors in guinea-pig	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1016/S0960-894X(00)80261-9
		2608	3779	74	None	-3	13	Guinea pig	6.5	pKd	=	6.5	Binding	Inhibition of specific binding of [3H]mepyramine to Histamine 1 receptors in guinea-pigInhibition of specific binding of [3H]mepyramine to Histamine 1 receptors in guinea-pig	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1016/S0960-894X(00)80261-9
		5405	3779	74	None	-3	13	Guinea pig	6.5	pKd	=	6.5	Binding	Inhibition of specific binding of [3H]mepyramine to Histamine 1 receptors in guinea-pigInhibition of specific binding of [3H]mepyramine to Histamine 1 receptors in guinea-pig	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1016/S0960-894X(00)80261-9
		CHEMBL17157	3779	74	None	-3	13	Guinea pig	6.5	pKd	=	6.5	Binding	Inhibition of specific binding of [3H]mepyramine to Histamine 1 receptors in guinea-pigInhibition of specific binding of [3H]mepyramine to Histamine 1 receptors in guinea-pig	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1016/S0960-894X(00)80261-9
		DB00342	3779	74	None	-3	13	Guinea pig	6.5	pKd	=	6.5	Binding	Inhibition of specific binding of [3H]mepyramine to Histamine 1 receptors in guinea-pigInhibition of specific binding of [3H]mepyramine to Histamine 1 receptors in guinea-pig	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1016/S0960-894X(00)80261-9
		118729369	117846	0	None	-	1	Guinea pig	6.5	pKd	=	6.5	Binding	Antagonist activity at histamine H1 receptor in guinea pig jejunum assessed as reduction in histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig jejunum assessed as reduction in histamine-induced contractions	ChEMBL	368	0	0	4	4.3	O=C(N1CCC(=C2c3ccccc3C=Cc3ccccc32)CC1)n1cncn1	10.1016/j.bmcl.2015.02.037
		CHEMBL3402827	117846	0	None	-	1	Guinea pig	6.5	pKd	=	6.5	Binding	Antagonist activity at histamine H1 receptor in guinea pig jejunum assessed as reduction in histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig jejunum assessed as reduction in histamine-induced contractions	ChEMBL	368	0	0	4	4.3	O=C(N1CCC(=C2c3ccccc3C=Cc3ccccc32)CC1)n1cncn1	10.1016/j.bmcl.2015.02.037
		11080253	36582	0	None	-2041	3	Guinea pig	5.5	pKd	=	5.5	Binding	Activity at Histamine H1 receptor using functional H1 receptor assay on guinea pig ileumActivity at Histamine H1 receptor using functional H1 receptor assay on guinea pig ileum	ChEMBL	417	11	1	4	5.9	c1ccc2c(NCCCCc3ccc(OCCCN4CCCCC4)cc3)ccnc2c1	10.1021/jm0110845
		CHEMBL14484	36582	0	None	-2041	3	Guinea pig	5.5	pKd	=	5.5	Binding	Activity at Histamine H1 receptor using functional H1 receptor assay on guinea pig ileumActivity at Histamine H1 receptor using functional H1 receptor assay on guinea pig ileum	ChEMBL	417	11	1	4	5.9	c1ccc2c(NCCCCc3ccc(OCCCN4CCCCC4)cc3)ccnc2c1	10.1021/jm0110845
		11748564	18933	0	None	-1584	3	Guinea pig	4.5	pKd	=	4.5	Binding	Receptor profile was evaluated at Histamine H1 receptor of guinea pig ileumReceptor profile was evaluated at Histamine H1 receptor of guinea pig ileum	ChEMBL	299	7	2	3	3.2	O=C(NC(c1ccccc1)C1CC1)OCCCc1c[nH]cn1	10.1021/jm020910m
		CHEMBL128585	18933	0	None	-1584	3	Guinea pig	4.5	pKd	=	4.5	Binding	Receptor profile was evaluated at Histamine H1 receptor of guinea pig ileumReceptor profile was evaluated at Histamine H1 receptor of guinea pig ileum	ChEMBL	299	7	2	3	3.2	O=C(NC(c1ccccc1)C1CC1)OCCCc1c[nH]cn1	10.1021/jm020910m
		60150164	175759	0	None	-107	2	Guinea pig	6.5	pKd	=	6.5	Binding	Antagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 5 mins followed by histamine addition during 30 mins equilibration period with washing every 10 minsAntagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 5 mins followed by histamine addition during 30 mins equilibration period with washing every 10 mins	ChEMBL	547	16	2	4	5.8	N=C(N)N(CCCCN1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccc(C(F)(F)F)cc1	10.1039/C8MD00527C
		CHEMBL4583515	175759	0	None	-107	2	Guinea pig	6.5	pKd	=	6.5	Binding	Antagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 5 mins followed by histamine addition during 30 mins equilibration period with washing every 10 minsAntagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 5 mins followed by histamine addition during 30 mins equilibration period with washing every 10 mins	ChEMBL	547	16	2	4	5.8	N=C(N)N(CCCCN1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccc(C(F)(F)F)cc1	10.1039/C8MD00527C
		11725577	11183	0	None	-26	3	Guinea pig	5.5	pKd	=	5.5	Binding	Potency at histamine H1 receptor subtype, was tested on guinea pig right ileumPotency at histamine H1 receptor subtype, was tested on guinea pig right ileum	ChEMBL	352	7	0	4	4.6	CO/N=C(\C)c1ccc(OCc2ccc(CN3CCCCC3)cc2)cc1	10.1021/jm021084k
		CHEMBL1178642	11183	0	None	-26	3	Guinea pig	5.5	pKd	=	5.5	Binding	Potency at histamine H1 receptor subtype, was tested on guinea pig right ileumPotency at histamine H1 receptor subtype, was tested on guinea pig right ileum	ChEMBL	352	7	0	4	4.6	CO/N=C(\C)c1ccc(OCc2ccc(CN3CCCCC3)cc2)cc1	10.1021/jm021084k
		CHEMBL35869	11183	0	None	-26	3	Guinea pig	5.5	pKd	=	5.5	Binding	Potency at histamine H1 receptor subtype, was tested on guinea pig right ileumPotency at histamine H1 receptor subtype, was tested on guinea pig right ileum	ChEMBL	352	7	0	4	4.6	CO/N=C(\C)c1ccc(OCc2ccc(CN3CCCCC3)cc2)cc1	10.1021/jm021084k
		2600	3779	74	None	-3	13	Guinea pig	7.5	pKd	=	7.5	Binding	Dissociation constant was determined against H1 receptor of guinea pig lung membranes using radioligand binding assays.Dissociation constant was determined against H1 receptor of guinea pig lung membranes using radioligand binding assays.	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1021/jm00013a023
		2608	3779	74	None	-3	13	Guinea pig	7.5	pKd	=	7.5	Binding	Dissociation constant was determined against H1 receptor of guinea pig lung membranes using radioligand binding assays.Dissociation constant was determined against H1 receptor of guinea pig lung membranes using radioligand binding assays.	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1021/jm00013a023
		5405	3779	74	None	-3	13	Guinea pig	7.5	pKd	=	7.5	Binding	Dissociation constant was determined against H1 receptor of guinea pig lung membranes using radioligand binding assays.Dissociation constant was determined against H1 receptor of guinea pig lung membranes using radioligand binding assays.	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1021/jm00013a023
		CHEMBL17157	3779	74	None	-3	13	Guinea pig	7.5	pKd	=	7.5	Binding	Dissociation constant was determined against H1 receptor of guinea pig lung membranes using radioligand binding assays.Dissociation constant was determined against H1 receptor of guinea pig lung membranes using radioligand binding assays.	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1021/jm00013a023
		DB00342	3779	74	None	-3	13	Guinea pig	7.5	pKd	=	7.5	Binding	Dissociation constant was determined against H1 receptor of guinea pig lung membranes using radioligand binding assays.Dissociation constant was determined against H1 receptor of guinea pig lung membranes using radioligand binding assays.	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1021/jm00013a023
		7048803	102303	4	None	-	1	Guinea pig	6.4	pKd	=	6.4	Binding	Inhibition of specific binding of [3H]mepyramine to Histamine 1 receptors in guinea-pigInhibition of specific binding of [3H]mepyramine to Histamine 1 receptors in guinea-pig	ChEMBL	471	8	2	3	6.4	CC(C)(C)c1ccc([C@H](O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1	10.1016/S0960-894X(00)80261-9
		CHEMBL303454	102303	4	None	-	1	Guinea pig	6.4	pKd	=	6.4	Binding	Inhibition of specific binding of [3H]mepyramine to Histamine 1 receptors in guinea-pigInhibition of specific binding of [3H]mepyramine to Histamine 1 receptors in guinea-pig	ChEMBL	471	8	2	3	6.4	CC(C)(C)c1ccc([C@H](O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1	10.1016/S0960-894X(00)80261-9
		90667232	109471	0	None	-	1	Guinea pig	5.4	pKd	=	5.4	Binding	Antagonist activity at guinea pig ileum histamine H1 receptor assessed as inhibition of histamine-induced response after 10 to 15 minsAntagonist activity at guinea pig ileum histamine H1 receptor assessed as inhibition of histamine-induced response after 10 to 15 mins	ChEMBL	313	7	3	2	2.0	CC(CC(=O)/N=C(\N)NCCCc1cn[nH]c1)c1ccccc1	10.1039/C3MD00245D
		CHEMBL3220633	109471	0	None	-	1	Guinea pig	5.4	pKd	=	5.4	Binding	Antagonist activity at guinea pig ileum histamine H1 receptor assessed as inhibition of histamine-induced response after 10 to 15 minsAntagonist activity at guinea pig ileum histamine H1 receptor assessed as inhibition of histamine-induced response after 10 to 15 mins	ChEMBL	313	7	3	2	2.0	CC(CC(=O)/N=C(\N)NCCCc1cn[nH]c1)c1ccccc1	10.1039/C3MD00245D
		10949464	98189	0	None	-5128	3	Guinea pig	5.4	pKd	=	5.4	Binding	Activity at Histamine H1 receptor using functional H1 receptor assay on guinea pig ileumActivity at Histamine H1 receptor using functional H1 receptor assay on guinea pig ileum	ChEMBL	403	10	1	4	5.5	c1ccc2c(NCCCc3ccc(OCCCN4CCCCC4)cc3)ccnc2c1	10.1021/jm0110845
		CHEMBL274041	98189	0	None	-5128	3	Guinea pig	5.4	pKd	=	5.4	Binding	Activity at Histamine H1 receptor using functional H1 receptor assay on guinea pig ileumActivity at Histamine H1 receptor using functional H1 receptor assay on guinea pig ileum	ChEMBL	403	10	1	4	5.5	c1ccc2c(NCCCc3ccc(OCCCN4CCCCC4)cc3)ccnc2c1	10.1021/jm0110845
		44352410	19585	0	None	-10	2	Guinea pig	4.4	pKd	=	4.4	Binding	Receptor profile was evaluated at Histamine H1 receptor of guinea pig ileumReceptor profile was evaluated at Histamine H1 receptor of guinea pig ileum	ChEMBL	270	5	1	3	3.0	CC(NC(=O)OCCCN1CCCCC1)C(C)(C)C	10.1021/jm020910m
		CHEMBL130005	19585	0	None	-10	2	Guinea pig	4.4	pKd	=	4.4	Binding	Receptor profile was evaluated at Histamine H1 receptor of guinea pig ileumReceptor profile was evaluated at Histamine H1 receptor of guinea pig ileum	ChEMBL	270	5	1	3	3.0	CC(NC(=O)OCCCN1CCCCC1)C(C)(C)C	10.1021/jm020910m
		168280938	190830	0	None	-	1	Human	8.4	pKd	=	8.4	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1270	33	9	14	4.2	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5184108	190830	0	None	-	1	Human	8.4	pKd	=	8.4	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1270	33	9	14	4.2	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		1204	1932	119	None	-501	24	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.1c00692
		1247	1932	119	None	-501	24	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.1c00692
		1375	1932	119	None	-501	24	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.1c00692
		774	1932	119	None	-501	24	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.1c00692
		CHEMBL90	1932	119	None	-501	24	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.1c00692
		DB05381	1932	119	None	-501	24	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.1c00692
		119570	3159	96	None	-162	40	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1021/acs.jmedchem.1c00692
		2233	3159	96	None	-162	40	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1021/acs.jmedchem.1c00692
		953	3159	96	None	-162	40	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1021/acs.jmedchem.1c00692
		CHEMBL301265	3159	96	None	-162	40	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1021/acs.jmedchem.1c00692
		DB00413	3159	96	None	-162	40	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1021/acs.jmedchem.1c00692
		168268716	192762	0	None	-1	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	372	3	4	4	3.5	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NC2CCCCC2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5170276	192762	0	None	-1	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	372	3	4	4	3.5	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NC2CCCCC2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221176	192762	0	None	-1	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	372	3	4	4	3.5	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NC2CCCCC2)cc1	10.1021/acs.jmedchem.1c00692
		168268680	192766	0	None	-1	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	662	11	8	8	4.8	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5172675	192766	0	None	-1	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	662	11	8	8	4.8	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221210	192766	0	None	-1	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	662	11	8	8	4.8	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1	10.1021/acs.jmedchem.1c00692
		168268827	192779	0	None	-4	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	450	8	4	4	4.8	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5179906	192779	0	None	-4	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	450	8	4	4	4.8	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221314	192779	0	None	-4	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	450	8	4	4	4.8	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)c1	10.1021/acs.jmedchem.1c00692
		168268853	192785	0	None	-19	6	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	389	8	4	5	1.9	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5180504	192785	0	None	-19	6	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	389	8	4	5	1.9	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221353	192785	0	None	-19	6	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	389	8	4	5	1.9	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
		168273471	192801	0	None	-12	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	596	17	8	10	0.7	N/C(=N\C(=O)NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5173079	192801	0	None	-12	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	596	17	8	10	0.7	N/C(=N\C(=O)NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221433	192801	0	None	-12	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	596	17	8	10	0.7	N/C(=N\C(=O)NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		168273549	192803	0	None	-1	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	436	6	4	4	4.3	Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5174342	192803	0	None	-1	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	436	6	4	4	4.3	Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221438	192803	0	None	-1	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	436	6	4	4	4.3	Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1	10.1021/acs.jmedchem.1c00692
		168273640	192805	0	None	-100	6	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	568	15	8	10	-0.1	N/C(=N\C(=O)NCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5176229	192805	0	None	-100	6	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	568	15	8	10	-0.1	N/C(=N\C(=O)NCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221444	192805	0	None	-100	6	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	568	15	8	10	-0.1	N/C(=N\C(=O)NCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		168273745	192808	0	None	-114	6	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	332	6	4	4	1.5	N/C(=N\C(=O)NCc1ccccc1)NCCCc1cnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5178472	192808	0	None	-114	6	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	332	6	4	4	1.5	N/C(=N\C(=O)NCc1ccccc1)NCCCc1cnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221451	192808	0	None	-114	6	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	332	6	4	4	1.5	N/C(=N\C(=O)NCc1ccccc1)NCCCc1cnc(N)s1	10.1021/acs.jmedchem.1c00692
		168274129	192809	0	None	-16	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	370	12	5	6	1.0	NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5176780	192809	0	None	-16	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	370	12	5	6	1.0	NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221468	192809	0	None	-16	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	370	12	5	6	1.0	NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		168275750	192826	0	None	-72	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	332	6	3	4	1.6	Cc1nnc(CCCN/C(N)=N/C(=O)NCc2ccccc2)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5175558	192826	0	None	-72	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	332	6	3	4	1.6	Cc1nnc(CCCN/C(N)=N/C(=O)NCc2ccccc2)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221581	192826	0	None	-72	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	332	6	3	4	1.6	Cc1nnc(CCCN/C(N)=N/C(=O)NCc2ccccc2)s1	10.1021/acs.jmedchem.1c00692
		168276867	192835	0	None	-1	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	662	11	8	8	4.8	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5174278	192835	0	None	-1	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	662	11	8	8	4.8	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221653	192835	0	None	-1	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	662	11	8	8	4.8	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)c1	10.1021/acs.jmedchem.1c00692
		168277996	192846	0	None	-60	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	380	4	4	4	3.3	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCc2ccccc2)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5173373	192846	0	None	-60	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	380	4	4	4	3.3	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCc2ccccc2)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221736	192846	0	None	-60	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	380	4	4	4	3.3	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCc2ccccc2)c1	10.1021/acs.jmedchem.1c00692
		168278471	192848	0	None	-229	6	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	312	8	4	4	1.5	CCCCCNC(=O)/N=C(\N)NCCCc1cnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5183205	192848	0	None	-229	6	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	312	8	4	4	1.5	CCCCCNC(=O)/N=C(\N)NCCCc1cnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221757	192848	0	None	-229	6	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	312	8	4	4	1.5	CCCCCNC(=O)/N=C(\N)NCCCc1cnc(N)s1	10.1021/acs.jmedchem.1c00692
		168278543	192851	0	None	-2	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	358	4	4	4	1.6	N/C(=N\C(=O)NCc1ccccc1)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		CHEMBL5184846	192851	0	None	-2	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	358	4	4	4	1.6	N/C(=N\C(=O)NCc1ccccc1)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221764	192851	0	None	-2	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	358	4	4	4	1.6	N/C(=N\C(=O)NCc1ccccc1)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		168280339	192865	0	None	3	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	372	8	3	5	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCn1cc(CN(C)C)nn1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5188592	192865	0	None	3	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	372	8	3	5	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCn1cc(CN(C)C)nn1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221885	192865	0	None	3	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	372	8	3	5	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCn1cc(CN(C)C)nn1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		168281536	192881	0	None	-2	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	369	12	4	5	1.7	Cc1nnc(CCCN/C(N)=N/C(=O)NCCCCCCCCN)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5189006	192881	0	None	-2	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	369	12	4	5	1.7	Cc1nnc(CCCN/C(N)=N/C(=O)NCCCCCCCCN)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221966	192881	0	None	-2	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	369	12	4	5	1.7	Cc1nnc(CCCN/C(N)=N/C(=O)NCCCCCCCCN)s1	10.1021/acs.jmedchem.1c00692
		168281746	192882	0	None	-14454	6	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	365	6	4	5	1.6	CC(NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1cccc(F)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5184911	192882	0	None	-14454	6	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	365	6	4	5	1.6	CC(NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1cccc(F)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221974	192882	0	None	-14454	6	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	365	6	4	5	1.6	CC(NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1cccc(F)c1	10.1021/acs.jmedchem.1c00692
		168283097	192893	0	None	-66	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	311	9	4	5	0.8	CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)o1	10.1021/acs.jmedchem.1c00692
		CHEMBL5186770	192893	0	None	-66	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	311	9	4	5	0.8	CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)o1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222043	192893	0	None	-66	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	311	9	4	5	0.8	CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)o1	10.1021/acs.jmedchem.1c00692
		168283321	192895	0	None	-2	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	364	7	4	4	2.3	Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCC(C)C1CCCCC1	10.1021/acs.jmedchem.1c00692
		CHEMBL5183015	192895	0	None	-2	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	364	7	4	4	2.3	Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCC(C)C1CCCCC1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222057	192895	0	None	-2	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	364	7	4	4	2.3	Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCC(C)C1CCCCC1	10.1021/acs.jmedchem.1c00692
		168283536	192900	0	None	-1	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	312	8	3	4	1.6	CCCCCNC(=O)/N=C(/N)NCCCc1nnc(C)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5187758	192900	0	None	-1	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	312	8	3	4	1.6	CCCCCNC(=O)/N=C(/N)NCCCc1nnc(C)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222074	192900	0	None	-1	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	312	8	3	4	1.6	CCCCCNC(=O)/N=C(/N)NCCCc1nnc(C)s1	10.1021/acs.jmedchem.1c00692
		168284289	192906	0	None	-3	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	428	8	4	4	3.1	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		CHEMBL5194860	192906	0	None	-3	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	428	8	4	4	3.1	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222123	192906	0	None	-3	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	428	8	4	4	3.1	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		168284480	192910	0	None	-66	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	330	6	4	4	1.3	Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCc1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5197548	192910	0	None	-66	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	330	6	4	4	1.3	Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCc1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222137	192910	0	None	-66	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	330	6	4	4	1.3	Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCc1ccccc1	10.1021/acs.jmedchem.1c00692
		168286141	192924	0	None	-3	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	450	8	4	4	4.8	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5192993	192924	0	None	-3	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	450	8	4	4	4.8	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222231	192924	0	None	-3	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	450	8	4	4	4.8	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)cc1	10.1021/acs.jmedchem.1c00692
		168286426	192926	0	None	-58	6	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	403	10	4	5	2.3	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5198795	192926	0	None	-58	6	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	403	10	4	5	2.3	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222241	192926	0	None	-58	6	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	403	10	4	5	2.3	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		168290235	192968	0	None	-12882	20	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5201074	192968	0	None	-12882	20	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222491	192968	0	None	-12882	20	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		168290815	192973	0	None	-10232	6	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	327	9	4	5	1.2	CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5200771	192973	0	None	-10232	6	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	327	9	4	5	1.2	CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222529	192973	0	None	-10232	6	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	327	9	4	5	1.2	CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		168291233	192979	0	None	-6	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	373	8	4	5	1.4	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)o2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5200106	192979	0	None	-6	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	373	8	4	5	1.4	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)o2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222556	192979	0	None	-6	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	373	8	4	5	1.4	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)o2)cc1	10.1021/acs.jmedchem.1c00692
		168292954	192997	0	None	-44	6	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	388	8	4	4	2.5	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2cnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5202592	192997	0	None	-44	6	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	388	8	4	4	2.5	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2cnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222660	192997	0	None	-44	6	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	388	8	4	4	2.5	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2cnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
		168294161	193006	0	None	-3	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	360	6	4	4	3.3	CCCCCNC(=O)/N=C(\N)Nc1cccc(-c2sc(N)nc2C)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5204739	193006	0	None	-3	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	360	6	4	4	3.3	CCCCCNC(=O)/N=C(\N)Nc1cccc(-c2sc(N)nc2C)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222742	193006	0	None	-3	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	360	6	4	4	3.3	CCCCCNC(=O)/N=C(\N)Nc1cccc(-c2sc(N)nc2C)c1	10.1021/acs.jmedchem.1c00692
		168294445	193010	0	None	1	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	414	6	4	4	2.6	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCC2CCc3nc(N)sc3C2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5208113	193010	0	None	1	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	414	6	4	4	2.6	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCC2CCc3nc(N)sc3C2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222768	193010	0	None	1	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	414	6	4	4	2.6	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCC2CCc3nc(N)sc3C2)cc1	10.1021/acs.jmedchem.1c00692
		168294166	193014	0	None	-1	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	360	6	4	4	3.3	CCCCCNC(=O)/N=C(\N)Nc1ccc(-c2sc(N)nc2C)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5209081	193014	0	None	-1	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	360	6	4	4	3.3	CCCCCNC(=O)/N=C(\N)Nc1ccc(-c2sc(N)nc2C)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222775	193014	0	None	-1	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	360	6	4	4	3.3	CCCCCNC(=O)/N=C(\N)Nc1ccc(-c2sc(N)nc2C)cc1	10.1021/acs.jmedchem.1c00692
		168294449	193018	0	None	-74	6	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	367	7	4	5	1.9	CC(CNC(=O)/N=C(\N)NCCCc1nnc(N)s1)C1CCCCC1	10.1021/acs.jmedchem.1c00692
		CHEMBL5204599	193018	0	None	-74	6	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	367	7	4	5	1.9	CC(CNC(=O)/N=C(\N)NCCCc1nnc(N)s1)C1CCCCC1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222793	193018	0	None	-74	6	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	367	7	4	5	1.9	CC(CNC(=O)/N=C(\N)NCCCc1nnc(N)s1)C1CCCCC1	10.1021/acs.jmedchem.1c00692
		168294767	193019	0	None	-3235	20	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5207281	193019	0	None	-3235	20	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222802	193019	0	None	-3235	20	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		168294770	193020	0	None	-2	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	436	6	4	4	4.3	Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5208327	193020	0	None	-2	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	436	6	4	4	4.3	Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222806	193020	0	None	-2	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	436	6	4	4	4.3	Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)cc1	10.1021/acs.jmedchem.1c00692
		168294776	193026	0	None	-11	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	366	7	3	4	2.6	Cc1nnc(CCCN/C(N)=N/C(=O)NCC(C)C2CCCCC2)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5209479	193026	0	None	-11	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	366	7	3	4	2.6	Cc1nnc(CCCN/C(N)=N/C(=O)NCC(C)C2CCCCC2)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222831	193026	0	None	-11	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	366	7	3	4	2.6	Cc1nnc(CCCN/C(N)=N/C(=O)NCC(C)C2CCCCC2)s1	10.1021/acs.jmedchem.1c00692
		168295528	193031	0	None	-2951	20	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5206565	193031	0	None	-2951	20	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222872	193031	0	None	-2951	20	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		168294178	193035	0	None	-1	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	414	5	4	4	4.4	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)C2CCCCC2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5205197	193035	0	None	-1	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	414	5	4	4	4.4	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)C2CCCCC2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222887	193035	0	None	-1	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	414	5	4	4	4.4	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)C2CCCCC2)cc1	10.1021/acs.jmedchem.1c00692
		168295541	193040	0	None	-301	6	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	347	6	4	5	1.4	C[C@@H](NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5208845	193040	0	None	-301	6	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	347	6	4	5	1.4	C[C@@H](NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222926	193040	0	None	-301	6	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	347	6	4	5	1.4	C[C@@H](NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		168295543	193041	0	None	-1	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	380	4	4	4	3.3	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCc2ccccc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5209021	193041	0	None	-1	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	380	4	4	4	3.3	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCc2ccccc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222929	193041	0	None	-1	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	380	4	4	4	3.3	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCc2ccccc2)cc1	10.1021/acs.jmedchem.1c00692
		168295803	193045	0	None	-3	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	338	6	4	4	1.6	CCCCCNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		CHEMBL5207206	193045	0	None	-3	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	338	6	4	4	1.6	CCCCCNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222937	193045	0	None	-3	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	338	6	4	4	1.6	CCCCCNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		168294182	193048	0	None	-57	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	314	6	4	2	1.7	C[C@@H](NC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5208722	193048	0	None	-57	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	314	6	4	2	1.7	C[C@@H](NC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222960	193048	0	None	-57	4	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	314	6	4	2	1.7	C[C@@H](NC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		168286984	191392	0	None	-	1	Human	8.3	pKd	=	8.3	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1254	32	8	13	5.2	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5192474	191392	0	None	-	1	Human	8.3	pKd	=	8.3	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1254	32	8	13	5.2	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168289844	191333	0	None	-	1	Human	8.3	pKd	=	8.3	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1284	34	9	14	4.6	CC[C@H](C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5191552	191333	0	None	-	1	Human	8.3	pKd	=	8.3	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1284	34	9	14	4.6	CC[C@H](C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		10744393	71464	0	None	-	1	Human	6.4	pKd	=	6.4	Binding	Dissociation constant against histamine H1 receptorDissociation constant against histamine H1 receptor	ChEMBL	514	8	2	5	4.7	O=C(N[C@H](CN1CCC(OC2c3ccccc3CCc3ccccc32)CC1)C(=O)O)OCc1ccccc1	10.1021/jm058225d
		CHEMBL196220	71464	0	None	-	1	Human	6.4	pKd	=	6.4	Binding	Dissociation constant against histamine H1 receptorDissociation constant against histamine H1 receptor	ChEMBL	514	8	2	5	4.7	O=C(N[C@H](CN1CCC(OC2c3ccccc3CCc3ccccc32)CC1)C(=O)O)OCc1ccccc1	10.1021/jm058225d
		156021916	178190	0	None	-	1	Human	6.4	pKd	=	6.4	Binding	Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayBinding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assay	ChEMBL	398	1	1	4	3.9	CCOC(=O)N1CC/C(=C2/c3ccc(Cl)cc3CCc3cccnc32)C(O)C1	10.1021/acs.jmedchem.0c00483
		CHEMBL4649344	178190	0	None	-	1	Human	6.4	pKd	=	6.4	Binding	Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayBinding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assay	ChEMBL	398	1	1	4	3.9	CCOC(=O)N1CC/C(=C2/c3ccc(Cl)cc3CCc3cccnc32)C(O)C1	10.1021/acs.jmedchem.0c00483
		168269233	189915	0	None	-	1	Human	7.4	pKd	=	7.4	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1205	30	7	11	5.8	Cc1cc(C)n2c1C=C1C=CC(/C=C/c3ccc(OCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc4ccccc4)NC(=O)CCN4CCC(Oc5ccccc5Cc5ccccc5)CC4)C(N)=O)cc3)=[N+]1[B-]2(F)F	10.1021/acs.jmedchem.2c00125
		CHEMBL5169872	189915	0	None	-	1	Human	7.4	pKd	=	7.4	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1205	30	7	11	5.8	Cc1cc(C)n2c1C=C1C=CC(/C=C/c3ccc(OCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc4ccccc4)NC(=O)CCN4CCC(Oc5ccccc5Cc5ccccc5)CC4)C(N)=O)cc3)=[N+]1[B-]2(F)F	10.1021/acs.jmedchem.2c00125
		168269233	189915	0	None	-	1	Human	7.4	pKd	=	7.4	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1205	30	7	11	5.8	Cc1cc(C)n2c1C=C1C=CC(/C=C/c3ccc(OCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc4ccccc4)NC(=O)CCN4CCC(Oc5ccccc5Cc5ccccc5)CC4)C(N)=O)cc3)=[N+]1[B-]2(F)F	10.1021/acs.jmedchem.2c00125
		CHEMBL5169872	189915	0	None	-	1	Human	7.4	pKd	=	7.4	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1205	30	7	11	5.8	Cc1cc(C)n2c1C=C1C=CC(/C=C/c3ccc(OCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc4ccccc4)NC(=O)CCN4CCC(Oc5ccccc5Cc5ccccc5)CC4)C(N)=O)cc3)=[N+]1[B-]2(F)F	10.1021/acs.jmedchem.2c00125
		156016191	177700	2	None	-	1	Human	6.3	pKd	=	6.3	Binding	Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayBinding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assay	ChEMBL	380	1	0	3	5.0	CCOC(=O)N1C=C/C(=C2/c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/acs.jmedchem.0c00483
		CHEMBL4642056	177700	2	None	-	1	Human	6.3	pKd	=	6.3	Binding	Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayBinding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assay	ChEMBL	380	1	0	3	5.0	CCOC(=O)N1C=C/C(=C2/c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/acs.jmedchem.0c00483
		156019460	177943	0	None	-	1	Human	6.3	pKd	=	6.3	Binding	Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayBinding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assay	ChEMBL	398	1	1	4	4.4	CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CC(O)c3cccnc32)CC1	10.1021/acs.jmedchem.0c00483
		CHEMBL4645629	177943	0	None	-	1	Human	6.3	pKd	=	6.3	Binding	Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayBinding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assay	ChEMBL	398	1	1	4	4.4	CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CC(O)c3cccnc32)CC1	10.1021/acs.jmedchem.0c00483
		10936212	11211	1	None	-74	3	Guinea pig	5.3	pKd	=	5.3	Binding	Potency at histamine H1 receptor subtype, was tested on guinea pig right ileumPotency at histamine H1 receptor subtype, was tested on guinea pig right ileum	ChEMBL	323	6	0	3	4.5	CC(=O)c1ccc(OCc2ccc(CN3CCCCC3)cc2)cc1	10.1021/jm021084k
		CHEMBL1178750	11211	1	None	-74	3	Guinea pig	5.3	pKd	=	5.3	Binding	Potency at histamine H1 receptor subtype, was tested on guinea pig right ileumPotency at histamine H1 receptor subtype, was tested on guinea pig right ileum	ChEMBL	323	6	0	3	4.5	CC(=O)c1ccc(OCc2ccc(CN3CCCCC3)cc2)cc1	10.1021/jm021084k
		CHEMBL39603	11211	1	None	-74	3	Guinea pig	5.3	pKd	=	5.3	Binding	Potency at histamine H1 receptor subtype, was tested on guinea pig right ileumPotency at histamine H1 receptor subtype, was tested on guinea pig right ileum	ChEMBL	323	6	0	3	4.5	CC(=O)c1ccc(OCc2ccc(CN3CCCCC3)cc2)cc1	10.1021/jm021084k
		14637770	178097	25	None	-	1	Human	7.3	pKd	=	7.3	Binding	Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayBinding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assay	ChEMBL	326	0	2	3	3.5	OC1Cc2cccnc2C(=C2CCNCC2)c2ccc(Cl)cc21	10.1021/acs.jmedchem.0c00483
		CHEMBL4647890	178097	25	None	-	1	Human	7.3	pKd	=	7.3	Binding	Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayBinding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assay	ChEMBL	326	0	2	3	3.5	OC1Cc2cccnc2C(=C2CCNCC2)c2ccc(Cl)cc21	10.1021/acs.jmedchem.0c00483
		168272779	190564	0	None	-	1	Human	8.3	pKd	=	8.3	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1191	27	6	14	6.2	C[C@H](NC(=O)CCN(C)CC/C=C1\c2ccccc2COc2ccccc21)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCC(=O)N[C@@H](CCCn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5180096	190564	0	None	-	1	Human	8.3	pKd	=	8.3	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1191	27	6	14	6.2	C[C@H](NC(=O)CCN(C)CC/C=C1\c2ccccc2COc2ccccc21)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCC(=O)N[C@@H](CCCn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168283831	190930	0	None	-	1	Human	8.3	pKd	=	8.3	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1256	32	9	14	3.9	C[C@H](NC(=O)[C@@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5185508	190930	0	None	-	1	Human	8.3	pKd	=	8.3	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1256	32	9	14	3.9	C[C@H](NC(=O)[C@@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168289844	191333	0	None	-	1	Human	8.3	pKd	=	8.3	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1284	34	9	14	4.6	CC[C@H](C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5191552	191333	0	None	-	1	Human	8.3	pKd	=	8.3	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1284	34	9	14	4.6	CC[C@H](C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168286984	191392	0	None	-	1	Human	8.3	pKd	=	8.3	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1254	32	8	13	5.2	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5192474	191392	0	None	-	1	Human	8.3	pKd	=	8.3	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1254	32	8	13	5.2	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168283831	190930	0	None	-	1	Human	8.3	pKd	=	8.3	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1256	32	9	14	3.9	C[C@H](NC(=O)[C@@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5185508	190930	0	None	-	1	Human	8.3	pKd	=	8.3	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1256	32	9	14	3.9	C[C@H](NC(=O)[C@@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168272779	190564	0	None	-	1	Human	8.3	pKd	=	8.3	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1191	27	6	14	6.2	C[C@H](NC(=O)CCN(C)CC/C=C1\c2ccccc2COc2ccccc21)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCC(=O)N[C@@H](CCCn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5180096	190564	0	None	-	1	Human	8.3	pKd	=	8.3	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1191	27	6	14	6.2	C[C@H](NC(=O)CCN(C)CC/C=C1\c2ccccc2COc2ccccc21)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCC(=O)N[C@@H](CCCn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168289771	191813	0	None	-	1	Human	8.2	pKd	=	8.2	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1284	34	9	14	4.6	CC(C)C[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5198492	191813	0	None	-	1	Human	8.2	pKd	=	8.2	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1284	34	9	14	4.6	CC(C)C[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168297510	192479	0	None	-	1	Human	8.2	pKd	=	8.2	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1305	32	9	14	6.0	C[C@H](NC(=O)[C@@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5208869	192479	0	None	-	1	Human	8.2	pKd	=	8.2	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1305	32	9	14	6.0	C[C@H](NC(=O)[C@@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		44461723	205955	0	None	398	2	Guinea pig	8.2	pKd	=	8.2	Binding	dissociation constant was determined against H1 receptor of guinea pig lung membranes using radioligand binding assays.dissociation constant was determined against H1 receptor of guinea pig lung membranes using radioligand binding assays.	ChEMBL	519	8	0	8	7.0	O=c1cc(C2N=NN=N2)oc2cc(OCCCN3CCC(=C(c4ccccc4)c4ccccc4)CC3)ccc12	10.1021/jm00013a023
		CHEMBL84407	205955	0	None	398	2	Guinea pig	8.2	pKd	=	8.2	Binding	dissociation constant was determined against H1 receptor of guinea pig lung membranes using radioligand binding assays.dissociation constant was determined against H1 receptor of guinea pig lung membranes using radioligand binding assays.	ChEMBL	519	8	0	8	7.0	O=c1cc(C2N=NN=N2)oc2cc(OCCCN3CCC(=C(c4ccccc4)c4ccccc4)CC3)ccc12	10.1021/jm00013a023
		10435880	205360	0	None	707	2	Guinea pig	8.2	pKd	=	8.2	Binding	Dissociation constant was determined against H1 receptor of guinea pig lung membranes using radioligand binding assays.Dissociation constant was determined against H1 receptor of guinea pig lung membranes using radioligand binding assays.	ChEMBL	495	8	1	5	5.9	O=C(O)c1cc(=O)c2cc(OCCCN3CCC(=C(c4ccccc4)c4ccccc4)CC3)ccc2o1	10.1021/jm00013a023
		CHEMBL79732	205360	0	None	707	2	Guinea pig	8.2	pKd	=	8.2	Binding	Dissociation constant was determined against H1 receptor of guinea pig lung membranes using radioligand binding assays.Dissociation constant was determined against H1 receptor of guinea pig lung membranes using radioligand binding assays.	ChEMBL	495	8	1	5	5.9	O=C(O)c1cc(=O)c2cc(OCCCN3CCC(=C(c4ccccc4)c4ccccc4)CC3)ccc2o1	10.1021/jm00013a023
		10067161	44119	1	None	-30199	3	Guinea pig	5.3	pKd	=	5.3	Binding	Activity at Histamine H1 receptor using functional H1 receptor assay on guinea pig ileumActivity at Histamine H1 receptor using functional H1 receptor assay on guinea pig ileum	ChEMBL	361	7	1	4	5.2	c1ccc2c(Nc3ccc(OCCCN4CCCCC4)cc3)ccnc2c1	10.1021/jm0110845
		CHEMBL15153	44119	1	None	-30199	3	Guinea pig	5.3	pKd	=	5.3	Binding	Activity at Histamine H1 receptor using functional H1 receptor assay on guinea pig ileumActivity at Histamine H1 receptor using functional H1 receptor assay on guinea pig ileum	ChEMBL	361	7	1	4	5.2	c1ccc2c(Nc3ccc(OCCCN4CCCCC4)cc3)ccnc2c1	10.1021/jm0110845
		11107010	18965	2	None	-1000	3	Guinea pig	4.3	pKd	=	4.3	Binding	Receptor profile was evaluated at Histamine H1 receptor of guinea pig ileumReceptor profile was evaluated at Histamine H1 receptor of guinea pig ileum	ChEMBL	224	6	1	2	3.2	CC(CC(C)(C)C)OCCCc1c[nH]cn1	10.1021/jm020910m
		CHEMBL128714	18965	2	None	-1000	3	Guinea pig	4.3	pKd	=	4.3	Binding	Receptor profile was evaluated at Histamine H1 receptor of guinea pig ileumReceptor profile was evaluated at Histamine H1 receptor of guinea pig ileum	ChEMBL	224	6	1	2	3.2	CC(CC(C)(C)C)OCCCc1c[nH]cn1	10.1021/jm020910m
		10956869	63052	0	None	-5128	3	Guinea pig	4.3	pKd	=	4.3	Binding	Receptor profile was evaluated at Histamine H1 receptor of guinea pig ileumReceptor profile was evaluated at Histamine H1 receptor of guinea pig ileum	ChEMBL	279	6	2	3	3.0	C[C@@H](NC(=O)OCCCc1c[nH]cn1)C1CCCCC1	10.1021/jm020910m
		CHEMBL1788247	63052	0	None	-5128	3	Guinea pig	4.3	pKd	=	4.3	Binding	Receptor profile was evaluated at Histamine H1 receptor of guinea pig ileumReceptor profile was evaluated at Histamine H1 receptor of guinea pig ileum	ChEMBL	279	6	2	3	3.0	C[C@@H](NC(=O)OCCCc1c[nH]cn1)C1CCCCC1	10.1021/jm020910m
		156012578	177359	0	None	-	1	Human	7.3	pKd	=	7.3	Binding	Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayBinding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assay	ChEMBL	414	1	2	5	3.5	CCOC(=O)N1C(O)CC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1O	10.1021/acs.jmedchem.0c00483
		CHEMBL4637657	177359	0	None	-	1	Human	7.3	pKd	=	7.3	Binding	Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayBinding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assay	ChEMBL	414	1	2	5	3.5	CCOC(=O)N1C(O)CC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1O	10.1021/acs.jmedchem.0c00483
		168297282	192477	0	None	-	1	Human	5.3	pKd	=	5.3	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1225	36	10	13	2.4	Cc1cc(C)n2c1C=C1C=CC(CCC(=O)NCCCCCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CCN3CCC(Oc4ccccc4Cc4ccccc4)CC3)C(C)C)C(N)=O)=[N+]1[B-]2(F)F	10.1021/acs.jmedchem.2c00125
		CHEMBL5208850	192477	0	None	-	1	Human	5.3	pKd	=	5.3	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1225	36	10	13	2.4	Cc1cc(C)n2c1C=C1C=CC(CCC(=O)NCCCCCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CCN3CCC(Oc4ccccc4Cc4ccccc4)CC3)C(C)C)C(N)=O)=[N+]1[B-]2(F)F	10.1021/acs.jmedchem.2c00125
		168297282	192477	0	None	-	1	Human	5.3	pKd	=	5.3	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1225	36	10	13	2.4	Cc1cc(C)n2c1C=C1C=CC(CCC(=O)NCCCCCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CCN3CCC(Oc4ccccc4Cc4ccccc4)CC3)C(C)C)C(N)=O)=[N+]1[B-]2(F)F	10.1021/acs.jmedchem.2c00125
		CHEMBL5208850	192477	0	None	-	1	Human	5.3	pKd	=	5.3	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1225	36	10	13	2.4	Cc1cc(C)n2c1C=C1C=CC(CCC(=O)NCCCCCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CCN3CCC(Oc4ccccc4Cc4ccccc4)CC3)C(C)C)C(N)=O)=[N+]1[B-]2(F)F	10.1021/acs.jmedchem.2c00125
		277	1301	62	None	-2	50	Human	5.3	pKd	=	5.3	Binding	Dissociation constant against histamine H1 receptorDissociation constant against histamine H1 receptor	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1021/jm058225d
		2913	1301	62	None	-2	50	Human	5.3	pKd	=	5.3	Binding	Dissociation constant against histamine H1 receptorDissociation constant against histamine H1 receptor	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1021/jm058225d
		765	1301	62	None	-2	50	Human	5.3	pKd	=	5.3	Binding	Dissociation constant against histamine H1 receptorDissociation constant against histamine H1 receptor	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1021/jm058225d
		CHEMBL516	1301	62	None	-2	50	Human	5.3	pKd	=	5.3	Binding	Dissociation constant against histamine H1 receptorDissociation constant against histamine H1 receptor	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1021/jm058225d
		DB00434	1301	62	None	-2	50	Human	5.3	pKd	=	5.3	Binding	Dissociation constant against histamine H1 receptorDissociation constant against histamine H1 receptor	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1021/jm058225d
		168289021	191777	0	None	-	1	Human	8.2	pKd	=	8.2	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1272	33	10	15	2.9	C[C@@H](O)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5197990	191777	0	None	-	1	Human	8.2	pKd	=	8.2	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1272	33	10	15	2.9	C[C@@H](O)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168289771	191813	0	None	-	1	Human	8.2	pKd	=	8.2	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1284	34	9	14	4.6	CC(C)C[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5198492	191813	0	None	-	1	Human	8.2	pKd	=	8.2	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1284	34	9	14	4.6	CC(C)C[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168297510	192479	0	None	-	1	Human	8.2	pKd	=	8.2	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1305	32	9	14	6.0	C[C@H](NC(=O)[C@@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5208869	192479	0	None	-	1	Human	8.2	pKd	=	8.2	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1305	32	9	14	6.0	C[C@H](NC(=O)[C@@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		24824726	161109	1	None	2	6	Human	8.2	pKd	=	8.2	Binding	Antagonist activity at histamine H1 receptor in human isolated trachea assessed as change in histamine-induced contractionAntagonist activity at histamine H1 receptor in human isolated trachea assessed as change in histamine-induced contraction	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL4060529	161109	1	None	2	6	Human	8.2	pKd	=	8.2	Binding	Antagonist activity at histamine H1 receptor in human isolated trachea assessed as change in histamine-induced contractionAntagonist activity at histamine H1 receptor in human isolated trachea assessed as change in histamine-induced contraction	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL4117079	161109	1	None	2	6	Human	8.2	pKd	=	8.2	Binding	Antagonist activity at histamine H1 receptor in human isolated trachea assessed as change in histamine-induced contractionAntagonist activity at histamine H1 receptor in human isolated trachea assessed as change in histamine-induced contraction	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL5282336	161109	1	None	2	6	Human	8.2	pKd	=	8.2	Binding	Antagonist activity at histamine H1 receptor in human isolated trachea assessed as change in histamine-induced contractionAntagonist activity at histamine H1 receptor in human isolated trachea assessed as change in histamine-induced contraction	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL5286389	161109	1	None	2	6	Human	8.2	pKd	=	8.2	Binding	Antagonist activity at histamine H1 receptor in human isolated trachea assessed as change in histamine-induced contractionAntagonist activity at histamine H1 receptor in human isolated trachea assessed as change in histamine-induced contraction	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		168289021	191777	0	None	-	1	Human	8.2	pKd	=	8.2	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1272	33	10	15	2.9	C[C@@H](O)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5197990	191777	0	None	-	1	Human	8.2	pKd	=	8.2	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1272	33	10	15	2.9	C[C@@H](O)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168295200	192389	0	None	-	1	Human	8.2	pKd	=	8.2	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1321	33	10	15	5.0	C[C@@H](O)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5207609	192389	0	None	-	1	Human	8.2	pKd	=	8.2	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1321	33	10	15	5.0	C[C@@H](O)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		155539314	176380	0	None	-5	2	Guinea pig	7.2	pKd	=	7.2	Binding	Antagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 minsAntagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 mins	ChEMBL	628	14	4	4	5.0	N=C(N)N(CCCCN1CCN(CCCCN(Cc2ccc(C(F)(F)F)cc2)C(=N)N)CC1)Cc1ccc(C(F)(F)F)cc1	10.1039/C8MD00527C
		CHEMBL4514561	176380	0	None	-5	2	Guinea pig	7.2	pKd	=	7.2	Binding	Antagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 minsAntagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 mins	ChEMBL	628	14	4	4	5.0	N=C(N)N(CCCCN1CCN(CCCCN(Cc2ccc(C(F)(F)F)cc2)C(=N)N)CC1)Cc1ccc(C(F)(F)F)cc1	10.1039/C8MD00527C
		CHEMBL4595855	176380	0	None	-5	2	Guinea pig	7.2	pKd	=	7.2	Binding	Antagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 minsAntagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 mins	ChEMBL	628	14	4	4	5.0	N=C(N)N(CCCCN1CCN(CCCCN(Cc2ccc(C(F)(F)F)cc2)C(=N)N)CC1)Cc1ccc(C(F)(F)F)cc1	10.1039/C8MD00527C
		155553524	176519	0	None	-5	2	Guinea pig	7.2	pKd	=	7.2	Binding	Antagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 minsAntagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 mins	ChEMBL	546	16	2	3	7.3	N=C(N)N(CCCCN1CCC(CCCCCCCOc2ccccc2)CC1)Cc1ccc(C(F)(F)F)cc1	10.1039/C8MD00527C
		CHEMBL4546027	176519	0	None	-5	2	Guinea pig	7.2	pKd	=	7.2	Binding	Antagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 minsAntagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 mins	ChEMBL	546	16	2	3	7.3	N=C(N)N(CCCCN1CCC(CCCCCCCOc2ccccc2)CC1)Cc1ccc(C(F)(F)F)cc1	10.1039/C8MD00527C
		CHEMBL4596938	176519	0	None	-5	2	Guinea pig	7.2	pKd	=	7.2	Binding	Antagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 minsAntagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 mins	ChEMBL	546	16	2	3	7.3	N=C(N)N(CCCCN1CCC(CCCCCCCOc2ccccc2)CC1)Cc1ccc(C(F)(F)F)cc1	10.1039/C8MD00527C
		168283519	191064	0	None	-	1	Human	7.2	pKd	=	7.2	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1216	32	9	13	3.1	Cc1cc(C)n2c1C=C1C=CC(/C=C/c3ccc(OCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CCN4CCC(Oc5ccccc5Cc5ccccc5)CC4)C(C)C)C(N)=O)cc3)=[N+]1[B-]2(F)F	10.1021/acs.jmedchem.2c00125
		CHEMBL5187345	191064	0	None	-	1	Human	7.2	pKd	=	7.2	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1216	32	9	13	3.1	Cc1cc(C)n2c1C=C1C=CC(/C=C/c3ccc(OCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CCN4CCC(Oc5ccccc5Cc5ccccc5)CC4)C(C)C)C(N)=O)cc3)=[N+]1[B-]2(F)F	10.1021/acs.jmedchem.2c00125
		155565680	176245	0	None	-6	2	Guinea pig	7.2	pKd	=	7.2	Binding	Antagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 minsAntagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 mins	ChEMBL	547	16	3	4	5.7	N=C(NCCCCN1CCN(CCCCCCCOc2ccccc2)CC1)NCc1ccc(C(F)(F)F)cc1	10.1039/C8MD00527C
		CHEMBL4579190	176245	0	None	-6	2	Guinea pig	7.2	pKd	=	7.2	Binding	Antagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 minsAntagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 mins	ChEMBL	547	16	3	4	5.7	N=C(NCCCCN1CCN(CCCCCCCOc2ccccc2)CC1)NCc1ccc(C(F)(F)F)cc1	10.1039/C8MD00527C
		CHEMBL4594800	176245	0	None	-6	2	Guinea pig	7.2	pKd	=	7.2	Binding	Antagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 minsAntagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 mins	ChEMBL	547	16	3	4	5.7	N=C(NCCCCN1CCN(CCCCCCCOc2ccccc2)CC1)NCc1ccc(C(F)(F)F)cc1	10.1039/C8MD00527C
		168283519	191064	0	None	-	1	Human	7.2	pKd	=	7.2	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1216	32	9	13	3.1	Cc1cc(C)n2c1C=C1C=CC(/C=C/c3ccc(OCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CCN4CCC(Oc5ccccc5Cc5ccccc5)CC4)C(C)C)C(N)=O)cc3)=[N+]1[B-]2(F)F	10.1021/acs.jmedchem.2c00125
		CHEMBL5187345	191064	0	None	-	1	Human	7.2	pKd	=	7.2	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1216	32	9	13	3.1	Cc1cc(C)n2c1C=C1C=CC(/C=C/c3ccc(OCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CCN4CCC(Oc5ccccc5Cc5ccccc5)CC4)C(C)C)C(N)=O)cc3)=[N+]1[B-]2(F)F	10.1021/acs.jmedchem.2c00125
		168295200	192389	0	None	-	1	Human	8.2	pKd	=	8.2	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1321	33	10	15	5.0	C[C@@H](O)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5207609	192389	0	None	-	1	Human	8.2	pKd	=	8.2	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1321	33	10	15	5.0	C[C@@H](O)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168276508	190266	0	None	-	1	Human	8.1	pKd	=	8.1	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells incubated for 1 hr using furimazine as substrate measured after 5 mins by NanoBRET binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells incubated for 1 hr using furimazine as substrate measured after 5 mins by NanoBRET binding assay	ChEMBL	1140	28	6	11	6.9	C[C@@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](C)C(=O)N[C@H](C)C(=O)NCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1	10.1021/acs.jmedchem.2c00125
		CHEMBL5175488	190266	0	None	-	1	Human	8.1	pKd	=	8.1	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells incubated for 1 hr using furimazine as substrate measured after 5 mins by NanoBRET binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells incubated for 1 hr using furimazine as substrate measured after 5 mins by NanoBRET binding assay	ChEMBL	1140	28	6	11	6.9	C[C@@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](C)C(=O)N[C@H](C)C(=O)NCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1	10.1021/acs.jmedchem.2c00125
		2200	20203	61	None	26	2	Guinea pig	7.1	pKd	=	7.1	Binding	Antagonist activity at H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced ileum contraction measured after 15 minsAntagonist activity at H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced ileum contraction measured after 15 mins	ChEMBL	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	10.1016/j.ejmech.2018.04.043
		CHEMBL1256819	20203	61	None	26	2	Guinea pig	7.1	pKd	=	7.1	Binding	Antagonist activity at H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced ileum contraction measured after 15 minsAntagonist activity at H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced ileum contraction measured after 15 mins	ChEMBL	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	10.1016/j.ejmech.2018.04.043
		CHEMBL1305	20203	61	None	26	2	Guinea pig	7.1	pKd	=	7.1	Binding	Antagonist activity at H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced ileum contraction measured after 15 minsAntagonist activity at H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced ileum contraction measured after 15 mins	ChEMBL	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	10.1016/j.ejmech.2018.04.043
		1605	2342	117	None	1	4	Guinea pig	7.1	pKd	=	7.1	Binding	Antagonist activity at histamine H1 receptor in guinea pig jejunum assessed as reduction in histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig jejunum assessed as reduction in histamine-induced contractions	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1016/j.bmcl.2015.02.037
		3957	2342	117	None	1	4	Guinea pig	7.1	pKd	=	7.1	Binding	Antagonist activity at histamine H1 receptor in guinea pig jejunum assessed as reduction in histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig jejunum assessed as reduction in histamine-induced contractions	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1016/j.bmcl.2015.02.037
		7216	2342	117	None	1	4	Guinea pig	7.1	pKd	=	7.1	Binding	Antagonist activity at histamine H1 receptor in guinea pig jejunum assessed as reduction in histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig jejunum assessed as reduction in histamine-induced contractions	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1016/j.bmcl.2015.02.037
		CHEMBL998	2342	117	None	1	4	Guinea pig	7.1	pKd	=	7.1	Binding	Antagonist activity at histamine H1 receptor in guinea pig jejunum assessed as reduction in histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig jejunum assessed as reduction in histamine-induced contractions	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1016/j.bmcl.2015.02.037
		DB00455	2342	117	None	1	4	Guinea pig	7.1	pKd	=	7.1	Binding	Antagonist activity at histamine H1 receptor in guinea pig jejunum assessed as reduction in histamine-induced contractionsAntagonist activity at histamine H1 receptor in guinea pig jejunum assessed as reduction in histamine-induced contractions	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1016/j.bmcl.2015.02.037
		2200	20203	61	None	26	2	Guinea pig	7.1	pKd	=	7.1	Binding	Antagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions after 15 minsAntagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions after 15 mins	ChEMBL	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	10.1016/j.bmc.2019.02.020
		CHEMBL1256819	20203	61	None	26	2	Guinea pig	7.1	pKd	=	7.1	Binding	Antagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions after 15 minsAntagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions after 15 mins	ChEMBL	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	10.1016/j.bmc.2019.02.020
		CHEMBL1305	20203	61	None	26	2	Guinea pig	7.1	pKd	=	7.1	Binding	Antagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions after 15 minsAntagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions after 15 mins	ChEMBL	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	10.1016/j.bmc.2019.02.020
		2200	20203	61	None	26	2	Guinea pig	7.1	pKd	=	7.1	Binding	Antagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions incubated for 15 minsAntagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions incubated for 15 mins	ChEMBL	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	10.1016/j.bmc.2017.07.058
		CHEMBL1256819	20203	61	None	26	2	Guinea pig	7.1	pKd	=	7.1	Binding	Antagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions incubated for 15 minsAntagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions incubated for 15 mins	ChEMBL	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	10.1016/j.bmc.2017.07.058
		CHEMBL1305	20203	61	None	26	2	Guinea pig	7.1	pKd	=	7.1	Binding	Antagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions incubated for 15 minsAntagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions incubated for 15 mins	ChEMBL	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	10.1016/j.bmc.2017.07.058
		168296109	192423	0	None	-	1	Human	6.1	pKd	=	6.1	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1155	29	7	11	5.6	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCC1=[N+]2C(=Cc3ccc(-c4cccs4)n3[B-]2(F)F)C=C1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5208169	192423	0	None	-	1	Human	6.1	pKd	=	6.1	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1155	29	7	11	5.6	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCC1=[N+]2C(=Cc3ccc(-c4cccs4)n3[B-]2(F)F)C=C1)C(N)=O	10.1021/acs.jmedchem.2c00125
		155567030	176417	0	None	-21	4	Guinea pig	6.1	pKd	=	6.1	Binding	Antagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions incubated for 15 minsAntagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions incubated for 15 mins	ChEMBL	337	8	0	2	5.8	c1ccc(-c2ccc(OCCCCCN3CCCCCC3)cc2)cc1	10.1016/j.bmc.2017.07.058
		CHEMBL4586133	176417	0	None	-21	4	Guinea pig	6.1	pKd	=	6.1	Binding	Antagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions incubated for 15 minsAntagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions incubated for 15 mins	ChEMBL	337	8	0	2	5.8	c1ccc(-c2ccc(OCCCCCN3CCCCCC3)cc2)cc1	10.1016/j.bmc.2017.07.058
		CHEMBL4596108	176417	0	None	-21	4	Guinea pig	6.1	pKd	=	6.1	Binding	Antagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions incubated for 15 minsAntagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions incubated for 15 mins	ChEMBL	337	8	0	2	5.8	c1ccc(-c2ccc(OCCCCCN3CCCCCC3)cc2)cc1	10.1016/j.bmc.2017.07.058
		168296109	192423	0	None	-	1	Human	6.1	pKd	=	6.1	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1155	29	7	11	5.6	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCC1=[N+]2C(=Cc3ccc(-c4cccs4)n3[B-]2(F)F)C=C1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5208169	192423	0	None	-	1	Human	6.1	pKd	=	6.1	Binding	Binding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assayBinding affinity to NLuc-tagged human H1R expressed in HEK293T cells using NanoGlo as substrate preincubated for 2 hrs followed by substrate addition measured after 5 min by NanoBRET saturation binding assay	ChEMBL	1155	29	7	11	5.6	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCC1=[N+]2C(=Cc3ccc(-c4cccs4)n3[B-]2(F)F)C=C1)C(N)=O	10.1021/acs.jmedchem.2c00125
		1278	2150	84	None	-288	8	Guinea pig	6.1	pKd	=	6.1	Binding	Antagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions after 15 minsAntagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions after 15 mins	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmc.2019.02.020
		1279	2150	84	None	-288	8	Guinea pig	6.1	pKd	=	6.1	Binding	Antagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions after 15 minsAntagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions after 15 mins	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmc.2019.02.020
		4908365	2150	84	None	-288	8	Guinea pig	6.1	pKd	=	6.1	Binding	Antagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions after 15 minsAntagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions after 15 mins	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmc.2019.02.020
		CHEMBL129198	2150	84	None	-288	8	Guinea pig	6.1	pKd	=	6.1	Binding	Antagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions after 15 minsAntagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions after 15 mins	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmc.2019.02.020
		155540474	176273	0	None	-10	2	Guinea pig	7.1	pKd	=	7.1	Binding	Antagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 minsAntagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 mins	ChEMBL	479	16	3	4	4.7	N=C(NCCCCN1CCN(CCCCCCCOc2ccccc2)CC1)NCc1ccccc1	10.1039/C8MD00527C
		CHEMBL4482871	176273	0	None	-10	2	Guinea pig	7.1	pKd	=	7.1	Binding	Antagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 minsAntagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 mins	ChEMBL	479	16	3	4	4.7	N=C(NCCCCN1CCN(CCCCCCCOc2ccccc2)CC1)NCc1ccccc1	10.1039/C8MD00527C
		CHEMBL4595050	176273	0	None	-10	2	Guinea pig	7.1	pKd	=	7.1	Binding	Antagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 minsAntagonist activity at histamine H1 receptor in guinea pig ileum preincubated for 10 mins followed by histamine addition during 30 mins equilibration period with washing every 10 mins	ChEMBL	479	16	3	4	4.7	N=C(NCCCCN1CCN(CCCCCCCOc2ccccc2)CC1)NCc1ccccc1	10.1039/C8MD00527C
		10873565	37836	0	None	-1584	3	Guinea pig	6.1	pKd	=	6.1	Binding	Activity at Histamine H1 receptor using functional H1 receptor assay on guinea pig ileumActivity at Histamine H1 receptor using functional H1 receptor assay on guinea pig ileum	ChEMBL	423	9	1	4	5.8	Clc1ccc2c(NCCc3ccc(OCCCN4CCCCC4)cc3)ccnc2c1	10.1021/jm0110845
		CHEMBL14587	37836	0	None	-1584	3	Guinea pig	6.1	pKd	=	6.1	Binding	Activity at Histamine H1 receptor using functional H1 receptor assay on guinea pig ileumActivity at Histamine H1 receptor using functional H1 receptor assay on guinea pig ileum	ChEMBL	423	9	1	4	5.8	Clc1ccc2c(NCCc3ccc(OCCCN4CCCCC4)cc3)ccnc2c1	10.1021/jm0110845
		11048988	40949	0	None	-3981	3	Guinea pig	5.1	pKd	=	5.1	Binding	Activity at Histamine H1 receptor using functional H1 receptor assay on guinea pig ileumActivity at Histamine H1 receptor using functional H1 receptor assay on guinea pig ileum	ChEMBL	471	11	1	4	6.8	c1ccc2c(NCCCCc3ccc(OCCCN4CCCCC4)cc3)c3c(nc2c1)CCCC3	10.1021/jm0110845
		CHEMBL14868	40949	0	None	-3981	3	Guinea pig	5.1	pKd	=	5.1	Binding	Activity at Histamine H1 receptor using functional H1 receptor assay on guinea pig ileumActivity at Histamine H1 receptor using functional H1 receptor assay on guinea pig ileum	ChEMBL	471	11	1	4	6.8	c1ccc2c(NCCCCc3ccc(OCCCN4CCCCC4)cc3)c3c(nc2c1)CCCC3	10.1021/jm0110845
		11046028	152538	0	None	-144	3	Guinea pig	5.1	pKd	=	5.1	Binding	Potency at histamine H1 receptor subtype, was tested on guinea pig right ileumPotency at histamine H1 receptor subtype, was tested on guinea pig right ileum	ChEMBL	338	6	1	4	4.5	C/C(=N\O)c1ccc(OCc2ccc(CN3CCCCC3)cc2)cc1	10.1021/jm021084k
		CHEMBL39716	152538	0	None	-144	3	Guinea pig	5.1	pKd	=	5.1	Binding	Potency at histamine H1 receptor subtype, was tested on guinea pig right ileumPotency at histamine H1 receptor subtype, was tested on guinea pig right ileum	ChEMBL	338	6	1	4	4.5	C/C(=N\O)c1ccc(OCc2ccc(CN3CCCCC3)cc2)cc1	10.1021/jm021084k
		11089134	21404	0	None	-151	3	Guinea pig	5.1	pKd	=	5.1	Binding	Receptor profile was evaluated at Histamine H1 receptor of guinea pig ileumReceptor profile was evaluated at Histamine H1 receptor of guinea pig ileum	ChEMBL	341	7	2	3	4.4	O=C(NC(c1ccccc1)C1CCCCC1)OCCCc1c[nH]cn1	10.1021/jm020910m
		CHEMBL131476	21404	0	None	-151	3	Guinea pig	5.1	pKd	=	5.1	Binding	Receptor profile was evaluated at Histamine H1 receptor of guinea pig ileumReceptor profile was evaluated at Histamine H1 receptor of guinea pig ileum	ChEMBL	341	7	2	3	4.4	O=C(NC(c1ccccc1)C1CCCCC1)OCCCc1c[nH]cn1	10.1021/jm020910m
		9866657	12018	0	None	-512	3	Guinea pig	5.0	pKd	=	5.0	Binding	Potency at histamine H1 receptor subtype, was tested on guinea pig right ileumPotency at histamine H1 receptor subtype, was tested on guinea pig right ileum	ChEMBL	309	6	0	3	4.1	CC(=O)c1ccc(OCc2ccc(CN3CCCC3)cc2)cc1	10.1021/jm021084k
		CHEMBL1183328	12018	0	None	-512	3	Guinea pig	5.0	pKd	=	5.0	Binding	Potency at histamine H1 receptor subtype, was tested on guinea pig right ileumPotency at histamine H1 receptor subtype, was tested on guinea pig right ileum	ChEMBL	309	6	0	3	4.1	CC(=O)c1ccc(OCc2ccc(CN3CCCC3)cc2)cc1	10.1021/jm021084k
		CHEMBL290613	12018	0	None	-512	3	Guinea pig	5.0	pKd	=	5.0	Binding	Potency at histamine H1 receptor subtype, was tested on guinea pig right ileumPotency at histamine H1 receptor subtype, was tested on guinea pig right ileum	ChEMBL	309	6	0	3	4.1	CC(=O)c1ccc(OCc2ccc(CN3CCCC3)cc2)cc1	10.1021/jm021084k
		26987	949	33	None	16	21	Human	10.3	pKi	=	10.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		6063	949	33	None	16	21	Human	10.3	pKi	=	10.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		671	949	33	None	16	21	Human	10.3	pKi	=	10.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		CHEMBL1626	949	33	None	16	21	Human	10.3	pKi	=	10.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		DB00283	949	33	None	16	21	Human	10.3	pKi	=	10.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		3158	56267	27	None	40	20	Human	10.2	pKi	=	10.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
		CHEMBL1628227	56267	27	None	40	20	Human	10.2	pKi	=	10.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
		15749406	12274	0	None	-	1	Guinea pig	9.9	pKi	=	9.9	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	293	3	0	2	4.3	Cc1ccc2c(c1)/C(=C/CCN(C)C)c1ccccc1CO2	10.1021/jm00089a020
		CHEMBL1184758	12274	0	None	-	1	Guinea pig	9.9	pKi	=	9.9	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	293	3	0	2	4.3	Cc1ccc2c(c1)/C(=C/CCN(C)C)c1ccccc1CO2	10.1021/jm00089a020
		CHEMBL366965	12274	0	None	-	1	Guinea pig	9.9	pKi	=	9.9	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	293	3	0	2	4.3	Cc1ccc2c(c1)/C(=C/CCN(C)C)c1ccccc1CO2	10.1021/jm00089a020
		1530	2182	50	None	-5	21	Human	9.9	pKi	=	9.9	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		3827	2182	50	None	-5	21	Human	9.9	pKi	=	9.9	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		7206	2182	50	None	-5	21	Human	9.9	pKi	=	9.9	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		CHEMBL534	2182	50	None	-5	21	Human	9.9	pKi	=	9.9	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		DB00920	2182	50	None	-5	21	Human	9.9	pKi	=	9.9	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		135	2532	43	None	-1	58	Human	9.8	pKi	=	9.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		1796	2532	43	None	-1	58	Human	9.8	pKi	=	9.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		4184	2532	43	None	-1	58	Human	9.8	pKi	=	9.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		CHEMBL6437	2532	43	None	-1	58	Human	9.8	pKi	=	9.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		DB06148	2532	43	None	-1	58	Human	9.8	pKi	=	9.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		1225	1471	26	None	-1	22	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]mepyramine from human H1R expressed in HEK293T cell homogenates incubated for 1 hr by radioligand binding assay based liquid scintillation counterDisplacement of [3H]mepyramine from human H1R expressed in HEK293T cell homogenates incubated for 1 hr by radioligand binding assay based liquid scintillation counter	ChEMBL	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	10.1021/acs.jmedchem.2c00125
		3958	1471	26	None	-1	22	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]mepyramine from human H1R expressed in HEK293T cell homogenates incubated for 1 hr by radioligand binding assay based liquid scintillation counterDisplacement of [3H]mepyramine from human H1R expressed in HEK293T cell homogenates incubated for 1 hr by radioligand binding assay based liquid scintillation counter	ChEMBL	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	10.1021/acs.jmedchem.2c00125
		667477	1471	26	None	-1	22	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]mepyramine from human H1R expressed in HEK293T cell homogenates incubated for 1 hr by radioligand binding assay based liquid scintillation counterDisplacement of [3H]mepyramine from human H1R expressed in HEK293T cell homogenates incubated for 1 hr by radioligand binding assay based liquid scintillation counter	ChEMBL	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	10.1021/acs.jmedchem.2c00125
		CHEMBL860	1471	26	None	-1	22	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]mepyramine from human H1R expressed in HEK293T cell homogenates incubated for 1 hr by radioligand binding assay based liquid scintillation counterDisplacement of [3H]mepyramine from human H1R expressed in HEK293T cell homogenates incubated for 1 hr by radioligand binding assay based liquid scintillation counter	ChEMBL	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	10.1021/acs.jmedchem.2c00125
		DB01142	1471	26	None	-1	22	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]mepyramine from human H1R expressed in HEK293T cell homogenates incubated for 1 hr by radioligand binding assay based liquid scintillation counterDisplacement of [3H]mepyramine from human H1R expressed in HEK293T cell homogenates incubated for 1 hr by radioligand binding assay based liquid scintillation counter	ChEMBL	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	10.1021/acs.jmedchem.2c00125
		3158	56267	27	None	40	20	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1021/jm2011589
		CHEMBL1628227	56267	27	None	40	20	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1021/jm2011589
		1238	203174	24	None	-38	16	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsDisplacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm100652h
		CHEMBL64249	203174	24	None	-38	16	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsDisplacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm100652h
		3158	56267	27	None	40	20	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1021/acs.jmedchem.6b00981
		CHEMBL1628227	56267	27	None	40	20	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1021/acs.jmedchem.6b00981
		46884735	7973	0	None	11481	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	316	5	0	3	4.3	C[C@H](C1=C(CCN(C)C)Cc2cc(F)ccc21)c1nccs1	10.1016/j.bmcl.2010.02.055
		CHEMBL1090527	7973	0	None	11481	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	316	5	0	3	4.3	C[C@H](C1=C(CCN(C)C)Cc2cc(F)ccc21)c1nccs1	10.1016/j.bmcl.2010.02.055
		135398745	2914	112	None	-1	65	Rat	9.5	pKi	=	9.5	Binding	Half-maximal inhibition of [3H]7-OH-DPAT binding to Histamine H1 receptor in rat tissue homogenateHalf-maximal inhibition of [3H]7-OH-DPAT binding to Histamine H1 receptor in rat tissue homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm010982y
		47	2914	112	None	-1	65	Rat	9.5	pKi	=	9.5	Binding	Half-maximal inhibition of [3H]7-OH-DPAT binding to Histamine H1 receptor in rat tissue homogenateHalf-maximal inhibition of [3H]7-OH-DPAT binding to Histamine H1 receptor in rat tissue homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm010982y
		CHEMBL715	2914	112	None	-1	65	Rat	9.5	pKi	=	9.5	Binding	Half-maximal inhibition of [3H]7-OH-DPAT binding to Histamine H1 receptor in rat tissue homogenateHalf-maximal inhibition of [3H]7-OH-DPAT binding to Histamine H1 receptor in rat tissue homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm010982y
		DB00334	2914	112	None	-1	65	Rat	9.5	pKi	=	9.5	Binding	Half-maximal inhibition of [3H]7-OH-DPAT binding to Histamine H1 receptor in rat tissue homogenateHalf-maximal inhibition of [3H]7-OH-DPAT binding to Histamine H1 receptor in rat tissue homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm010982y
		1530	2182	50	None	5	21	Guinea pig	9.5	pKi	=	9.5	Binding	The compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMThe compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1021/jm00089a020
		3827	2182	50	None	5	21	Guinea pig	9.5	pKi	=	9.5	Binding	The compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMThe compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1021/jm00089a020
		7206	2182	50	None	5	21	Guinea pig	9.5	pKi	=	9.5	Binding	The compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMThe compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1021/jm00089a020
		CHEMBL534	2182	50	None	5	21	Guinea pig	9.5	pKi	=	9.5	Binding	The compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMThe compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1021/jm00089a020
		DB00920	2182	50	None	5	21	Guinea pig	9.5	pKi	=	9.5	Binding	The compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMThe compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1021/jm00089a020
		71452601	84207	0	None	100	2	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	434	8	1	5	4.5	N#Cc1cccc(OC[C@@H](O)CCN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1	10.1016/j.bmcl.2012.09.113
		CHEMBL2208424	84207	0	None	100	2	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	434	8	1	5	4.5	N#Cc1cccc(OC[C@@H](O)CCN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1	10.1016/j.bmcl.2012.09.113
		2286	3183	51	None	-2	30	Human	9.5	pKi	=	9.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		4927	3183	51	None	-2	30	Human	9.5	pKi	=	9.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		7282	3183	51	None	-2	30	Human	9.5	pKi	=	9.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		CHEMBL643	3183	51	None	-2	30	Human	9.5	pKi	=	9.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		DB01069	3183	51	None	-2	30	Human	9.5	pKi	=	9.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		1201549	597	24	None	-1	20	Human	9.4	pKi	=	9.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		333	597	24	None	-1	20	Human	9.4	pKi	=	9.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		7601	597	24	None	-1	20	Human	9.4	pKi	=	9.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		CHEMBL1201203	597	24	None	-1	20	Human	9.4	pKi	=	9.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		CHEMBL438151	597	24	None	-1	20	Human	9.4	pKi	=	9.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		DB00245	597	24	None	-1	20	Human	9.4	pKi	=	9.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		31843	163565	83	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	324	0	0	2	4.4	CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/acs.jmedchem.9b00447
		CHEMBL420316	163565	83	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	324	0	0	2	4.4	CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/acs.jmedchem.9b00447
		CHEMBL4551989	163565	83	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	324	0	0	2	4.4	CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/acs.jmedchem.9b00447
		2284	3182	33	None	1	29	Human	9.4	pKi	=	9.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		4926	3182	33	None	1	29	Human	9.4	pKi	=	9.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		7281	3182	33	None	1	29	Human	9.4	pKi	=	9.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		CHEMBL564	3182	33	None	1	29	Human	9.4	pKi	=	9.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		DB00420	3182	33	None	1	29	Human	9.4	pKi	=	9.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		12963076	196625	4	None	162	7	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation counting	ChEMBL	292	5	0	2	4.1	C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm900933k
		CHEMBL564226	196625	4	None	162	7	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation counting	ChEMBL	292	5	0	2	4.1	C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm900933k
		10315110	171857	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	338	1	0	2	4.8	CCN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/acs.jmedchem.9b00447
		CHEMBL4469024	171857	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	338	1	0	2	4.8	CCN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/acs.jmedchem.9b00447
		277	1301	62	None	-2	50	Human	9.4	pKi	=	9.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		2913	1301	62	None	-2	50	Human	9.4	pKi	=	9.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		765	1301	62	None	-2	50	Human	9.4	pKi	=	9.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		CHEMBL516	1301	62	None	-2	50	Human	9.4	pKi	=	9.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		DB00434	1301	62	None	-2	50	Human	9.4	pKi	=	9.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		9839050	112379	0	None	1	9	Human	9.4	pKi	=	9.4	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	293	2	0	2	3.8	CN(C)C[C@H]1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1	10.1021/jm049632c
		CHEMBL329566	112379	0	None	1	9	Human	9.4	pKi	=	9.4	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	293	2	0	2	3.8	CN(C)C[C@H]1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1	10.1021/jm049632c
		1227	2489	43	None	-2	12	Human	9.4	pKi	=	9.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		2331	2489	43	None	-2	12	Human	9.4	pKi	=	9.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		3957	2489	43	None	-2	12	Human	9.4	pKi	=	9.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		4992	2489	43	None	-2	12	Human	9.4	pKi	=	9.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		CHEMBL511	2489	43	None	-2	12	Human	9.4	pKi	=	9.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		DB06691	2489	43	None	-2	12	Human	9.4	pKi	=	9.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		12963076	196625	4	None	162	7	Human	9.4	pKi	=	9.4	Binding	Compound was evaluated for binding affinity towards cloned human histamine H1 receptors stably expressed in CHO-K1 cells using [3H]mepyramineCompound was evaluated for binding affinity towards cloned human histamine H1 receptors stably expressed in CHO-K1 cells using [3H]mepyramine	ChEMBL	292	5	0	2	4.1	C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL564226	196625	4	None	162	7	Human	9.4	pKi	=	9.4	Binding	Compound was evaluated for binding affinity towards cloned human histamine H1 receptors stably expressed in CHO-K1 cells using [3H]mepyramineCompound was evaluated for binding affinity towards cloned human histamine H1 receptors stably expressed in CHO-K1 cells using [3H]mepyramine	ChEMBL	292	5	0	2	4.1	C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		15749404	203414	3	None	-	1	Guinea pig	9.3	pKi	=	9.3	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	323	5	1	3	3.5	CN(C)CC/C=C1\c2ccccc2COc2ccc(CCO)cc21	10.1021/jm00089a020
		CHEMBL65612	203414	3	None	-	1	Guinea pig	9.3	pKi	=	9.3	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	323	5	1	3	3.5	CN(C)CC/C=C1\c2ccccc2COc2ccc(CCO)cc21	10.1021/jm00089a020
		10333104	119589	0	None	43	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cellsDisplacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cells	ChEMBL	265	4	0	1	4.1	CN(C)CCCC1c2ccccc2Cc2ccccc21	10.1016/j.bmc.2009.08.016
		CHEMBL346230	119589	0	None	43	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cellsDisplacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cells	ChEMBL	265	4	0	1	4.1	CN(C)CCCC1c2ccccc2Cc2ccccc21	10.1016/j.bmc.2009.08.016
		11832931	161791	1	None	-	1	Rat	9.3	pKi	=	9.3	Binding	Tested for displacement of H-1 in rat brain by radioligand binding studiesTested for displacement of H-1 in rat brain by radioligand binding studies	ChEMBL	283	3	1	2	3.0	Cc1[nH]cnc1CCC(=O)N1CC(C)(C)c2ccccc21	10.1016/S0960-894X(00)80418-7
		CHEMBL414174	161791	1	None	-	1	Rat	9.3	pKi	=	9.3	Binding	Tested for displacement of H-1 in rat brain by radioligand binding studiesTested for displacement of H-1 in rat brain by radioligand binding studies	ChEMBL	283	3	1	2	3.0	Cc1[nH]cnc1CCC(=O)N1CC(C)(C)c2ccccc21	10.1016/S0960-894X(00)80418-7
		2435	3590	83	None	-95	48	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsDisplacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm100652h
		60149	3590	83	None	-95	48	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsDisplacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm100652h
		98	3590	83	None	-95	48	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsDisplacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm100652h
		CHEMBL12713	3590	83	None	-95	48	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsDisplacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm100652h
		DB06144	3590	83	None	-95	48	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsDisplacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm100652h
		44401164	69816	0	None	-2	9	Human	9.3	pKi	=	9.3	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL193639	69816	0	None	-2	9	Human	9.3	pKi	=	9.3	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		277	1301	62	None	2	50	Guinea pig	9.3	pKi	=	9.3	Binding	Inhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 minInhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 min	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1021/jm00017a019
		2913	1301	62	None	2	50	Guinea pig	9.3	pKi	=	9.3	Binding	Inhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 minInhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 min	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1021/jm00017a019
		765	1301	62	None	2	50	Guinea pig	9.3	pKi	=	9.3	Binding	Inhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 minInhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 min	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1021/jm00017a019
		CHEMBL516	1301	62	None	2	50	Guinea pig	9.3	pKi	=	9.3	Binding	Inhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 minInhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 min	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1021/jm00017a019
		DB00434	1301	62	None	2	50	Guinea pig	9.3	pKi	=	9.3	Binding	Inhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 minInhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 min	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1021/jm00017a019
		9839050	112379	0	None	1	9	Human	9.3	pKi	=	9.3	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	293	2	0	2	3.8	CN(C)C[C@H]1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1	10.1016/j.bmcl.2004.03.069
		CHEMBL329566	112379	0	None	1	9	Human	9.3	pKi	=	9.3	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	293	2	0	2	3.8	CN(C)C[C@H]1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1	10.1016/j.bmcl.2004.03.069
		180	401	56	None	-1	40	Human	9.3	pKi	=	9.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		200	401	56	None	-1	40	Human	9.3	pKi	=	9.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		2160	401	56	None	-1	40	Human	9.3	pKi	=	9.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		CHEMBL629	401	56	None	-1	40	Human	9.3	pKi	=	9.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		DB00321	401	56	None	-1	40	Human	9.3	pKi	=	9.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		135398737	958	93	None	2	89	Human	9.2	pKi	=	9.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		38	958	93	None	2	89	Human	9.2	pKi	=	9.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		722	958	93	None	2	89	Human	9.2	pKi	=	9.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		CHEMBL42	958	93	None	2	89	Human	9.2	pKi	=	9.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		DB00363	958	93	None	2	89	Human	9.2	pKi	=	9.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		42631003	199618	13	None	-2	8	Human	9.2	pKi	=	9.2	Binding	Binding affinity to histamine H1 receptor (unknown origin) assessed as inhibition constantBinding affinity to histamine H1 receptor (unknown origin) assessed as inhibition constant	ChEMBL	304	3	0	2	4.2	Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1	10.1016/j.ejmech.2022.114464
		CHEMBL592752	199618	13	None	-2	8	Human	9.2	pKi	=	9.2	Binding	Binding affinity to histamine H1 receptor (unknown origin) assessed as inhibition constantBinding affinity to histamine H1 receptor (unknown origin) assessed as inhibition constant	ChEMBL	304	3	0	2	4.2	Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1	10.1016/j.ejmech.2022.114464
		44247803	196086	0	None	-4	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation counting	ChEMBL	295	5	0	1	4.3	CN(C)CCC1=C(Cc2ccc(F)cc2)c2ccccc2C1	10.1021/jm900933k
		CHEMBL560741	196086	0	None	-4	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation counting	ChEMBL	295	5	0	1	4.3	CN(C)CCC1=C(Cc2ccc(F)cc2)c2ccccc2C1	10.1021/jm900933k
		44401164	69816	0	None	-2	9	Human	9.2	pKi	=	9.2	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL193639	69816	0	None	-2	9	Human	9.2	pKi	=	9.2	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		103	4153	61	None	-1	53	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human H1 receptorBinding affinity towards human H1 receptor	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm0002432
		2875	4153	61	None	-1	53	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human H1 receptorBinding affinity towards human H1 receptor	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm0002432
		5736	4153	61	None	-1	53	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human H1 receptorBinding affinity towards human H1 receptor	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm0002432
		CHEMBL285802	4153	61	None	-1	53	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human H1 receptorBinding affinity towards human H1 receptor	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm0002432
		DB09225	4153	61	None	-1	53	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human H1 receptorBinding affinity towards human H1 receptor	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm0002432
		44326705	112323	0	None	5	3	Human	9.2	pKi	=	9.2	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	293	2	0	2	3.8	CN(C)C[C@@H]1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1	10.1016/j.bmcl.2004.03.069
		CHEMBL329268	112323	0	None	5	3	Human	9.2	pKi	=	9.2	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	293	2	0	2	3.8	CN(C)C[C@@H]1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1	10.1016/j.bmcl.2004.03.069
		15749405	101063	14	None	-	1	Guinea pig	9.2	pKi	=	9.2	Binding	The compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMThe compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	323	5	1	3	3.5	CN(C)CC/C=C1/c2ccccc2COc2ccc(CCO)cc21	10.1021/jm00089a020
		CHEMBL294777	101063	14	None	-	1	Guinea pig	9.2	pKi	=	9.2	Binding	The compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMThe compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	323	5	1	3	3.5	CN(C)CC/C=C1/c2ccccc2COc2ccc(CCO)cc21	10.1021/jm00089a020
		CHEMBL5270515	194609	0	None	39	3	Human	9.2	pKi	=	9.2	Binding	Antagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysisAntagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysis	ChEMBL	452	8	1	5	3.6	CCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL5315265	194609	0	None	39	3	Human	9.2	pKi	=	9.2	Binding	Antagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysisAntagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysis	ChEMBL	452	8	1	5	3.6	CCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		155519275	170433	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	364	2	0	2	5.1	Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(CC2CC2)CC1	10.1021/acs.jmedchem.9b00447
		CHEMBL4448535	170433	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	364	2	0	2	5.1	Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(CC2CC2)CC1	10.1021/acs.jmedchem.9b00447
		9839081	111646	0	None	1	3	Human	9.2	pKi	=	9.2	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	294	2	0	3	3.4	CN(C)C[C@@H]1C[C@@H]2c3ccccc3Cc3ccccc3N2O1	10.1016/j.bmcl.2004.03.069
		CHEMBL328573	111646	0	None	1	3	Human	9.2	pKi	=	9.2	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	294	2	0	3	3.4	CN(C)C[C@@H]1C[C@@H]2c3ccccc3Cc3ccccc3N2O1	10.1016/j.bmcl.2004.03.069
		21855	84246	42	None	7	6	Human	9.2	pKi	=	9.2	Binding	Compound was evaluated for binding affinity towards cloned human histamine H1 receptors stably expressed in CHO-K1 cells using [3H]mepyramineCompound was evaluated for binding affinity towards cloned human histamine H1 receptors stably expressed in CHO-K1 cells using [3H]mepyramine	ChEMBL	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL22108	84246	42	None	7	6	Human	9.2	pKi	=	9.2	Binding	Compound was evaluated for binding affinity towards cloned human histamine H1 receptors stably expressed in CHO-K1 cells using [3H]mepyramineCompound was evaluated for binding affinity towards cloned human histamine H1 receptors stably expressed in CHO-K1 cells using [3H]mepyramine	ChEMBL	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		44326319	207211	0	None	9	3	Human	9.2	pKi	=	9.2	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	293	2	0	2	3.8	CN(C)CC1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1	10.1016/j.bmcl.2004.03.069
		CHEMBL92667	207211	0	None	9	3	Human	9.2	pKi	=	9.2	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	293	2	0	2	3.8	CN(C)CC1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1	10.1016/j.bmcl.2004.03.069
		46884734	7972	0	None	6	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	341	6	0	4	3.7	COc1nccnc1[C@H](C)C1=C(CCN(C)C)Cc2cc(F)ccc21	10.1016/j.bmcl.2010.02.055
		CHEMBL1090526	7972	0	None	6	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	341	6	0	4	3.7	COc1nccnc1[C@H](C)C1=C(CCN(C)C)Cc2cc(F)ccc21	10.1016/j.bmcl.2010.02.055
		46884734	7972	0	None	6	2	Human	9.2	pKi	=	9.2	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	341	6	0	4	3.7	COc1nccnc1[C@H](C)C1=C(CCN(C)C)Cc2cc(F)ccc21	10.1016/j.bmcl.2010.07.117
		CHEMBL1090526	7972	0	None	6	2	Human	9.2	pKi	=	9.2	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	341	6	0	4	3.7	COc1nccnc1[C@H](C)C1=C(CCN(C)C)Cc2cc(F)ccc21	10.1016/j.bmcl.2010.07.117
		1227	2489	43	None	-2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor in HEK293 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor in HEK293 cells after 60 mins by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/acs.jmedchem.6b01422
		2331	2489	43	None	-2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor in HEK293 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor in HEK293 cells after 60 mins by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/acs.jmedchem.6b01422
		3957	2489	43	None	-2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor in HEK293 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor in HEK293 cells after 60 mins by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/acs.jmedchem.6b01422
		4992	2489	43	None	-2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor in HEK293 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor in HEK293 cells after 60 mins by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/acs.jmedchem.6b01422
		CHEMBL511	2489	43	None	-2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor in HEK293 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor in HEK293 cells after 60 mins by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/acs.jmedchem.6b01422
		DB06691	2489	43	None	-2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor in HEK293 cells after 60 mins by scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor in HEK293 cells after 60 mins by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/acs.jmedchem.6b01422
		1210	918	51	None	-20	21	Human	9.1	pKi	=	9.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		1213	918	51	None	-20	21	Human	9.1	pKi	=	9.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		2725	918	51	None	-20	21	Human	9.1	pKi	=	9.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		33036	918	51	None	-20	21	Human	9.1	pKi	=	9.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		4411	918	51	None	-20	21	Human	9.1	pKi	=	9.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		616	918	51	None	-20	21	Human	9.1	pKi	=	9.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		6976	918	51	None	-20	21	Human	9.1	pKi	=	9.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		716121	918	51	None	-20	21	Human	9.1	pKi	=	9.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		CHEMBL1201353	918	51	None	-20	21	Human	9.1	pKi	=	9.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		CHEMBL1554789	918	51	None	-20	21	Human	9.1	pKi	=	9.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		CHEMBL505	918	51	None	-20	21	Human	9.1	pKi	=	9.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		DB01114	918	51	None	-20	21	Human	9.1	pKi	=	9.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		DB13679	918	51	None	-20	21	Human	9.1	pKi	=	9.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		CHEMBL5269671	194600	0	None	44	3	Human	9.1	pKi	=	9.1	Binding	Antagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysisAntagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysis	ChEMBL	466	9	1	5	4.0	CCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL5315170	194600	0	None	44	3	Human	9.1	pKi	=	9.1	Binding	Antagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysisAntagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysis	ChEMBL	466	9	1	5	4.0	CCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL5272034	194611	0	None	10	3	Human	9.1	pKi	=	9.1	Binding	Antagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysisAntagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysis	ChEMBL	496	11	1	6	3.6	COCCNC(=O)CCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL5315277	194611	0	None	10	3	Human	9.1	pKi	=	9.1	Binding	Antagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysisAntagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysis	ChEMBL	496	11	1	6	3.6	COCCNC(=O)CCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL5286701	194629	0	None	12	3	Human	9.1	pKi	=	9.1	Binding	Antagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysisAntagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysis	ChEMBL	482	10	1	6	3.3	COCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL5315483	194629	0	None	12	3	Human	9.1	pKi	=	9.1	Binding	Antagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysisAntagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysis	ChEMBL	482	10	1	6	3.3	COCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		155567541	175992	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	378	2	0	2	5.5	Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(CC2CCC2)CC1	10.1021/acs.jmedchem.9b00447
		CHEMBL4588983	175992	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	378	2	0	2	5.5	Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(CC2CCC2)CC1	10.1021/acs.jmedchem.9b00447
		46884666	8286	0	None	3019	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	298	5	0	3	4.2	C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1nccs1	10.1016/j.bmcl.2010.02.055
		CHEMBL1092598	8286	0	None	3019	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	298	5	0	3	4.2	C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1nccs1	10.1016/j.bmcl.2010.02.055
		11515387	8301	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	327	6	0	4	3.1	COc1nccnc1CC1=C(CCN(C)C)Cc2cc(F)ccc21	10.1016/j.bmcl.2010.02.055
		CHEMBL1092651	8301	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	327	6	0	4	3.1	COc1nccnc1CC1=C(CCN(C)C)Cc2cc(F)ccc21	10.1016/j.bmcl.2010.02.055
		652557	59458	13	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	330	6	1	5	2.3	O=C(CCN1CCN(Cc2ccccc2)CC1)Nc1nccs1	10.1021/acs.jmedchem.8b00718
		CHEMBL1712377	59458	13	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	330	6	1	5	2.3	O=C(CCN1CCN(Cc2ccccc2)CC1)Nc1nccs1	10.1021/acs.jmedchem.8b00718
		11759212	57892	0	None	40	6	Human	9.1	pKi	=	9.1	Binding	Compound was evaluated for binding affinity towards cloned human histamine H1 receptors stably expressed in CHO-K1 cells using [3H]mepyramineCompound was evaluated for binding affinity towards cloned human histamine H1 receptors stably expressed in CHO-K1 cells using [3H]mepyramine	ChEMBL	326	5	0	2	4.8	CC(C1=C(CCN(C)C)Cc2cc(Cl)ccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL167223	57892	0	None	40	6	Human	9.1	pKi	=	9.1	Binding	Compound was evaluated for binding affinity towards cloned human histamine H1 receptors stably expressed in CHO-K1 cells using [3H]mepyramineCompound was evaluated for binding affinity towards cloned human histamine H1 receptors stably expressed in CHO-K1 cells using [3H]mepyramine	ChEMBL	326	5	0	2	4.8	CC(C1=C(CCN(C)C)Cc2cc(Cl)ccc21)c1ccccn1	10.1021/jm020895l
		135	2532	43	None	-1	58	Guinea pig	9.1	pKi	=	9.1	Binding	Inhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 minInhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 min	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm00017a019
		1796	2532	43	None	-1	58	Guinea pig	9.1	pKi	=	9.1	Binding	Inhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 minInhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 min	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm00017a019
		4184	2532	43	None	-1	58	Guinea pig	9.1	pKi	=	9.1	Binding	Inhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 minInhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 min	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm00017a019
		CHEMBL6437	2532	43	None	-1	58	Guinea pig	9.1	pKi	=	9.1	Binding	Inhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 minInhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 min	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm00017a019
		DB06148	2532	43	None	-1	58	Guinea pig	9.1	pKi	=	9.1	Binding	Inhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 minInhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 min	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm00017a019
		44247935	196577	0	None	-2	3	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation counting	ChEMBL	294	5	0	3	4.1	C[C@@H](c1ccccn1)c1c(CCN(C)C)oc2ccccc12	10.1021/jm900933k
		CHEMBL563920	196577	0	None	-2	3	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation counting	ChEMBL	294	5	0	3	4.1	C[C@@H](c1ccccn1)c1c(CCN(C)C)oc2ccccc12	10.1021/jm900933k
		1210	918	51	None	-20	21	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/j.bmcl.2013.12.024
		1213	918	51	None	-20	21	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/j.bmcl.2013.12.024
		2725	918	51	None	-20	21	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/j.bmcl.2013.12.024
		33036	918	51	None	-20	21	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/j.bmcl.2013.12.024
		4411	918	51	None	-20	21	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/j.bmcl.2013.12.024
		616	918	51	None	-20	21	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/j.bmcl.2013.12.024
		6976	918	51	None	-20	21	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/j.bmcl.2013.12.024
		716121	918	51	None	-20	21	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/j.bmcl.2013.12.024
		CHEMBL1201353	918	51	None	-20	21	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/j.bmcl.2013.12.024
		CHEMBL1554789	918	51	None	-20	21	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/j.bmcl.2013.12.024
		CHEMBL505	918	51	None	-20	21	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/j.bmcl.2013.12.024
		DB01114	918	51	None	-20	21	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/j.bmcl.2013.12.024
		DB13679	918	51	None	-20	21	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/j.bmcl.2013.12.024
		1227	2489	43	None	-2	12	Human	9.0	pKi	=	9.0	Binding	Binding affinity to human histamine H1 receptor by radioligand displacement assayBinding affinity to human histamine H1 receptor by radioligand displacement assay	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.ejmech.2013.01.044
		2331	2489	43	None	-2	12	Human	9.0	pKi	=	9.0	Binding	Binding affinity to human histamine H1 receptor by radioligand displacement assayBinding affinity to human histamine H1 receptor by radioligand displacement assay	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.ejmech.2013.01.044
		3957	2489	43	None	-2	12	Human	9.0	pKi	=	9.0	Binding	Binding affinity to human histamine H1 receptor by radioligand displacement assayBinding affinity to human histamine H1 receptor by radioligand displacement assay	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.ejmech.2013.01.044
		4992	2489	43	None	-2	12	Human	9.0	pKi	=	9.0	Binding	Binding affinity to human histamine H1 receptor by radioligand displacement assayBinding affinity to human histamine H1 receptor by radioligand displacement assay	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.ejmech.2013.01.044
		CHEMBL511	2489	43	None	-2	12	Human	9.0	pKi	=	9.0	Binding	Binding affinity to human histamine H1 receptor by radioligand displacement assayBinding affinity to human histamine H1 receptor by radioligand displacement assay	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.ejmech.2013.01.044
		DB06691	2489	43	None	-2	12	Human	9.0	pKi	=	9.0	Binding	Binding affinity to human histamine H1 receptor by radioligand displacement assayBinding affinity to human histamine H1 receptor by radioligand displacement assay	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.ejmech.2013.01.044
		124087	1389	114	None	3	15	Human	9.0	pKi	=	9.0	Binding	Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsBinding affinity towards human histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1016/j.bmcl.2004.08.060
		7157	1389	114	None	3	15	Human	9.0	pKi	=	9.0	Binding	Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsBinding affinity towards human histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1016/j.bmcl.2004.08.060
		814	1389	114	None	3	15	Human	9.0	pKi	=	9.0	Binding	Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsBinding affinity towards human histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1016/j.bmcl.2004.08.060
		CHEMBL1172	1389	114	None	3	15	Human	9.0	pKi	=	9.0	Binding	Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsBinding affinity towards human histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1016/j.bmcl.2004.08.060
		DB00967	1389	114	None	3	15	Human	9.0	pKi	=	9.0	Binding	Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsBinding affinity towards human histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1016/j.bmcl.2004.08.060
		135398737	958	93	None	2	89	Human	9.0	pKi	=	9	Binding	Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		38	958	93	None	2	89	Human	9.0	pKi	=	9	Binding	Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		722	958	93	None	2	89	Human	9.0	pKi	=	9	Binding	Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		CHEMBL42	958	93	None	2	89	Human	9.0	pKi	=	9	Binding	Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		DB00363	958	93	None	2	89	Human	9.0	pKi	=	9	Binding	Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		46865650	8285	0	None	3715	2	Human	9.0	pKi	=	9	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	323	6	0	4	3.6	COc1nccnc1[C@H](C)C1=C(CCN(C)C)Cc2ccccc21	10.1016/j.bmcl.2010.02.055
		CHEMBL1092597	8285	0	None	3715	2	Human	9.0	pKi	=	9	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	323	6	0	4	3.6	COc1nccnc1[C@H](C)C1=C(CCN(C)C)Cc2ccccc21	10.1016/j.bmcl.2010.02.055
		163091	494	34	None	-6	10	Human	9.0	pKi	=	9	Binding	Binding affinity to H1 histamine receptor (unknown origin)Binding affinity to H1 histamine receptor (unknown origin)	ChEMBL	285	0	0	2	4.3	Clc1ccc2c(c1)[C@H]1CN(C[C@@H]1c1c(O2)cccc1)C	10.1016/j.bmcl.2020.127681
		22	494	34	None	-6	10	Human	9.0	pKi	=	9	Binding	Binding affinity to H1 histamine receptor (unknown origin)Binding affinity to H1 histamine receptor (unknown origin)	ChEMBL	285	0	0	2	4.3	Clc1ccc2c(c1)[C@H]1CN(C[C@@H]1c1c(O2)cccc1)C	10.1016/j.bmcl.2020.127681
		CHEMBL504548	494	34	None	-6	10	Human	9.0	pKi	=	9	Binding	Binding affinity to H1 histamine receptor (unknown origin)Binding affinity to H1 histamine receptor (unknown origin)	ChEMBL	285	0	0	2	4.3	Clc1ccc2c(c1)[C@H]1CN(C[C@@H]1c1c(O2)cccc1)C	10.1016/j.bmcl.2020.127681
		68168663	175695	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	352	1	0	2	5.1	CC(C)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/acs.jmedchem.9b00447
		CHEMBL4582006	175695	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	352	1	0	2	5.1	CC(C)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/acs.jmedchem.9b00447
		15662541	67772	0	None	-	1	Guinea pig	9.0	pKi	=	9	Binding	Inhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranesInhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	322	2	0	3	4.8	c1ccc2c(c1)Sc1ccccc1N2CC12CCN(CC1)CC2	10.1021/jm00017a019
		CHEMBL1908311	67772	0	None	-	1	Guinea pig	9.0	pKi	=	9	Binding	Inhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranesInhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	322	2	0	3	4.8	c1ccc2c(c1)Sc1ccccc1N2CC12CCN(CC1)CC2	10.1021/jm00017a019
		135398737	958	93	None	2	89	Human	9.0	pKi	=	9	Binding	Inhibition of histamine H1 receptor (unknown origin)Inhibition of histamine H1 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm401958n
		38	958	93	None	2	89	Human	9.0	pKi	=	9	Binding	Inhibition of histamine H1 receptor (unknown origin)Inhibition of histamine H1 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm401958n
		722	958	93	None	2	89	Human	9.0	pKi	=	9	Binding	Inhibition of histamine H1 receptor (unknown origin)Inhibition of histamine H1 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm401958n
		CHEMBL42	958	93	None	2	89	Human	9.0	pKi	=	9	Binding	Inhibition of histamine H1 receptor (unknown origin)Inhibition of histamine H1 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm401958n
		DB00363	958	93	None	2	89	Human	9.0	pKi	=	9	Binding	Inhibition of histamine H1 receptor (unknown origin)Inhibition of histamine H1 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm401958n
		4011	82408	49	None	6	24	Human	9.0	pKi	=	9.0	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
		CHEMBL21731	82408	49	None	6	24	Human	9.0	pKi	=	9.0	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
		135398737	958	93	None	2	89	Human	9.0	pKi	=	9.0	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
		38	958	93	None	2	89	Human	9.0	pKi	=	9.0	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
		722	958	93	None	2	89	Human	9.0	pKi	=	9.0	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
		CHEMBL42	958	93	None	2	89	Human	9.0	pKi	=	9.0	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
		DB00363	958	93	None	2	89	Human	9.0	pKi	=	9.0	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
		180	401	56	None	-1	40	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1016/j.bmcl.2008.09.012
		200	401	56	None	-1	40	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1016/j.bmcl.2008.09.012
		2160	401	56	None	-1	40	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1016/j.bmcl.2008.09.012
		CHEMBL629	401	56	None	-1	40	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1016/j.bmcl.2008.09.012
		DB00321	401	56	None	-1	40	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1016/j.bmcl.2008.09.012
		6761	67799	19	None	-1	18	Human	8.9	pKi	=	8.9	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	nan
		CHEMBL1909072	67799	19	None	-1	18	Human	8.9	pKi	=	8.9	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	nan
		124087	1389	114	None	3	15	Human	8.9	pKi	=	8.9	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		7157	1389	114	None	3	15	Human	8.9	pKi	=	8.9	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		814	1389	114	None	3	15	Human	8.9	pKi	=	8.9	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		CHEMBL1172	1389	114	None	3	15	Human	8.9	pKi	=	8.9	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		DB00967	1389	114	None	3	15	Human	8.9	pKi	=	8.9	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		44326442	107120	0	None	14	3	Human	8.9	pKi	=	8.9	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	366	2	0	4	4.0	CN1CCN(CC2C[C@@H]3c4ccccc4Sc4ccccc4[C@H]3O2)CC1	10.1016/j.bmcl.2004.03.069
		CHEMBL316068	107120	0	None	14	3	Human	8.9	pKi	=	8.9	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	366	2	0	4	4.0	CN1CCN(CC2C[C@@H]3c4ccccc4Sc4ccccc4[C@H]3O2)CC1	10.1016/j.bmcl.2004.03.069
		135398745	2914	112	None	1	65	Human	8.9	pKi	=	8.9	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049632c
		47	2914	112	None	1	65	Human	8.9	pKi	=	8.9	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049632c
		CHEMBL715	2914	112	None	1	65	Human	8.9	pKi	=	8.9	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049632c
		DB00334	2914	112	None	1	65	Human	8.9	pKi	=	8.9	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049632c
		44401106	124327	0	None	-1	9	Human	8.9	pKi	=	8.9	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL363581	124327	0	None	-1	9	Human	8.9	pKi	=	8.9	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		44290349	178537	0	None	131	2	Rat	8.9	pKi	=	8.9	Binding	Compound was evaluated for binding activity against [3H]pyrilamine as radioligand for Histamine H1 receptorCompound was evaluated for binding activity against [3H]pyrilamine as radioligand for Histamine H1 receptor	ChEMBL	411	5	2	6	2.1	O=C(c1ccc(F)cc1)C1CCN(CCn2c(=O)[nH]c3cc(O)ccc3c2=O)CC1	10.1021/jm00159a017
		CHEMBL46683	178537	0	None	131	2	Rat	8.9	pKi	=	8.9	Binding	Compound was evaluated for binding activity against [3H]pyrilamine as radioligand for Histamine H1 receptorCompound was evaluated for binding activity against [3H]pyrilamine as radioligand for Histamine H1 receptor	ChEMBL	411	5	2	6	2.1	O=C(c1ccc(F)cc1)C1CCN(CCn2c(=O)[nH]c3cc(O)ccc3c2=O)CC1	10.1021/jm00159a017
		2267	559	71	None	10	7	Human	8.9	pKi	=	8.9	Binding	Antagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysisAntagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysis	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1021/acsmedchemlett.7b00112
		271	559	71	None	10	7	Human	8.9	pKi	=	8.9	Binding	Antagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysisAntagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysis	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1021/acsmedchemlett.7b00112
		7121	559	71	None	10	7	Human	8.9	pKi	=	8.9	Binding	Antagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysisAntagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysis	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1021/acsmedchemlett.7b00112
		CHEMBL639	559	71	None	10	7	Human	8.9	pKi	=	8.9	Binding	Antagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysisAntagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysis	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1021/acsmedchemlett.7b00112
		DB00972	559	71	None	10	7	Human	8.9	pKi	=	8.9	Binding	Antagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysisAntagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysis	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1021/acsmedchemlett.7b00112
		CHEMBL5273244	194616	0	None	63	3	Human	8.9	pKi	=	8.9	Binding	Antagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysisAntagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysis	ChEMBL	468	9	1	6	2.9	COCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL5315364	194616	0	None	63	3	Human	8.9	pKi	=	8.9	Binding	Antagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysisAntagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysis	ChEMBL	468	9	1	6	2.9	COCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		155536963	172238	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	392	2	0	2	5.9	Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(CC2CCCC2)CC1	10.1021/acs.jmedchem.9b00447
		CHEMBL4474226	172238	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	392	2	0	2	5.9	Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(CC2CCCC2)CC1	10.1021/acs.jmedchem.9b00447
		1227	2489	43	None	-2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/acs.jmedchem.6b00981
		2331	2489	43	None	-2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/acs.jmedchem.6b00981
		3957	2489	43	None	-2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/acs.jmedchem.6b00981
		4992	2489	43	None	-2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/acs.jmedchem.6b00981
		CHEMBL511	2489	43	None	-2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/acs.jmedchem.6b00981
		DB06691	2489	43	None	-2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/acs.jmedchem.6b00981
		46884733	7911	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	353	7	0	5	3.6	COc1ccc2c(c1)CC(CCN(C)C)=C2[C@@H](C)c1nccnc1OC	10.1016/j.bmcl.2010.02.055
		CHEMBL1090186	7911	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	353	7	0	5	3.6	COc1ccc2c(c1)CC(CCN(C)C)=C2[C@@H](C)c1nccnc1OC	10.1016/j.bmcl.2010.02.055
		44247806	195668	2	None	14454	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	293	5	0	3	3.5	C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1cnccn1	10.1016/j.bmcl.2010.02.055
		CHEMBL556506	195668	2	None	14454	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	293	5	0	3	3.5	C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1cnccn1	10.1016/j.bmcl.2010.02.055
		44247806	195668	2	None	14454	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	293	5	0	3	3.5	C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1cnccn1	10.1016/j.bmcl.2010.12.053
		CHEMBL556506	195668	2	None	14454	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	293	5	0	3	3.5	C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1cnccn1	10.1016/j.bmcl.2010.12.053
		45272894	195655	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	375	4	0	5	4.3	Fc1ccc(Cn2c(N3CCC(n4ccnc4)CC3)nc3ccccc32)cc1	10.1016/j.bmcl.2009.05.086
		CHEMBL556449	195655	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	375	4	0	5	4.3	Fc1ccc(Cn2c(N3CCC(n4ccnc4)CC3)nc3ccccc32)cc1	10.1016/j.bmcl.2009.05.086
		44247806	195668	2	None	14454	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation counting	ChEMBL	293	5	0	3	3.5	C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1cnccn1	10.1021/jm900933k
		CHEMBL556506	195668	2	None	14454	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation counting	ChEMBL	293	5	0	3	3.5	C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1cnccn1	10.1021/jm900933k
		46884670	8223	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	313	5	0	3	3.6	CN(C)CCC1=C(Cc2cnccn2)c2ccc(Cl)cc2C1	10.1016/j.bmcl.2010.02.055
		CHEMBL1092259	8223	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	313	5	0	3	3.6	CN(C)CCC1=C(Cc2cnccn2)c2ccc(Cl)cc2C1	10.1016/j.bmcl.2010.02.055
		11702114	8299	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	297	5	0	3	3.1	CN(C)CCC1=C(Cc2cnccn2)c2ccc(F)cc2C1	10.1016/j.bmcl.2010.02.055
		CHEMBL1092649	8299	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	297	5	0	3	3.1	CN(C)CCC1=C(Cc2cnccn2)c2ccc(F)cc2C1	10.1016/j.bmcl.2010.02.055
		11186523	127511	0	None	1	9	Human	8.9	pKi	=	8.9	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1C[C@@H]2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL366164	127511	0	None	1	9	Human	8.9	pKi	=	8.9	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1C[C@@H]2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		1027	1576	73	None	6	2	Guinea pig	8.9	pKi	=	8.9	Binding	Inhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 minInhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 min	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1021/jm00017a019
		3241	1576	73	None	6	2	Guinea pig	8.9	pKi	=	8.9	Binding	Inhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 minInhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 min	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1021/jm00017a019
		7176	1576	73	None	6	2	Guinea pig	8.9	pKi	=	8.9	Binding	Inhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 minInhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 min	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1021/jm00017a019
		CHEMBL1106	1576	73	None	6	2	Guinea pig	8.9	pKi	=	8.9	Binding	Inhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 minInhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 min	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1021/jm00017a019
		DB00751	1576	73	None	6	2	Guinea pig	8.9	pKi	=	8.9	Binding	Inhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 minInhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 min	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1021/jm00017a019
		135398745	2914	112	None	1	65	Human	8.8	pKi	=	8.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		47	2914	112	None	1	65	Human	8.8	pKi	=	8.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		CHEMBL715	2914	112	None	1	65	Human	8.8	pKi	=	8.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		DB00334	2914	112	None	1	65	Human	8.8	pKi	=	8.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		46884698	8300	0	None	1318	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	343	6	0	4	3.6	COc1nccnc1CC1=C(CCN(C)C)Cc2cc(Cl)ccc21	10.1016/j.bmcl.2010.02.055
		CHEMBL1092650	8300	0	None	1318	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	343	6	0	4	3.6	COc1nccnc1CC1=C(CCN(C)C)Cc2cc(Cl)ccc21	10.1016/j.bmcl.2010.02.055
		45272876	196503	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	348	4	0	4	3.9	Cc1ccc(Cn2c(N3CCC(N(C)C)CC3)nc3ccccc32)cc1	10.1016/j.bmcl.2009.05.086
		CHEMBL563451	196503	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	348	4	0	4	3.9	Cc1ccc(Cn2c(N3CCC(N(C)C)CC3)nc3ccccc32)cc1	10.1016/j.bmcl.2009.05.086
		44247806	195668	2	None	14454	2	Human	8.8	pKi	=	8.8	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	293	5	0	3	3.5	C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1cnccn1	10.1016/j.bmcl.2010.07.117
		CHEMBL556506	195668	2	None	14454	2	Human	8.8	pKi	=	8.8	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	293	5	0	3	3.5	C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1cnccn1	10.1016/j.bmcl.2010.07.117
		124087	1389	114	None	3	15	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1021/acs.jmedchem.9b00447
		7157	1389	114	None	3	15	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1021/acs.jmedchem.9b00447
		814	1389	114	None	3	15	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1021/acs.jmedchem.9b00447
		CHEMBL1172	1389	114	None	3	15	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1021/acs.jmedchem.9b00447
		DB00967	1389	114	None	3	15	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1021/acs.jmedchem.9b00447
		1227	2489	43	None	-2	12	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells after 3 hrsDisplacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells after 3 hrs	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmcl.2013.01.025
		2331	2489	43	None	-2	12	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells after 3 hrsDisplacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells after 3 hrs	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmcl.2013.01.025
		3957	2489	43	None	-2	12	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells after 3 hrsDisplacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells after 3 hrs	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmcl.2013.01.025
		4992	2489	43	None	-2	12	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells after 3 hrsDisplacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells after 3 hrs	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmcl.2013.01.025
		CHEMBL511	2489	43	None	-2	12	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells after 3 hrsDisplacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells after 3 hrs	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmcl.2013.01.025
		DB06691	2489	43	None	-2	12	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells after 3 hrsDisplacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells after 3 hrs	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmcl.2013.01.025
		1228	3866	34	None	-5	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]pyrilamine from histamine H1 receptorDisplacement of [3H]pyrilamine from histamine H1 receptor	ChEMBL	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	10.1021/np50094a001
		2763	3866	34	None	-5	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]pyrilamine from histamine H1 receptorDisplacement of [3H]pyrilamine from histamine H1 receptor	ChEMBL	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	10.1021/np50094a001
		5282443	3866	34	None	-5	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]pyrilamine from histamine H1 receptorDisplacement of [3H]pyrilamine from histamine H1 receptor	ChEMBL	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	10.1021/np50094a001
		CHEMBL855	3866	34	None	-5	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]pyrilamine from histamine H1 receptorDisplacement of [3H]pyrilamine from histamine H1 receptor	ChEMBL	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	10.1021/np50094a001
		DB00427	3866	34	None	-5	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]pyrilamine from histamine H1 receptorDisplacement of [3H]pyrilamine from histamine H1 receptor	ChEMBL	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	10.1021/np50094a001
		1816	2540	102	None	-3	18	Human	8.8	pKi	=	8.8	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
		4205	2540	102	None	-3	18	Human	8.8	pKi	=	8.8	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
		7241	2540	102	None	-3	18	Human	8.8	pKi	=	8.8	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
		CHEMBL654	2540	102	None	-3	18	Human	8.8	pKi	=	8.8	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
		DB00370	2540	102	None	-3	18	Human	8.8	pKi	=	8.8	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
		2247	505	81	None	-4	42	Human	8.8	pKi	=	8.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		249	505	81	None	-4	42	Human	8.8	pKi	=	8.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		2603	505	81	None	-4	42	Human	8.8	pKi	=	8.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		CHEMBL296419	505	81	None	-4	42	Human	8.8	pKi	=	8.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		DB00637	505	81	None	-4	42	Human	8.8	pKi	=	8.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		1228	3866	34	None	5	4	Guinea pig	8.8	pKi	=	8.8	Binding	Inhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 minInhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 min	ChEMBL	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	10.1021/jm00017a019
		2763	3866	34	None	5	4	Guinea pig	8.8	pKi	=	8.8	Binding	Inhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 minInhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 min	ChEMBL	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	10.1021/jm00017a019
		5282443	3866	34	None	5	4	Guinea pig	8.8	pKi	=	8.8	Binding	Inhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 minInhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 min	ChEMBL	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	10.1021/jm00017a019
		CHEMBL855	3866	34	None	5	4	Guinea pig	8.8	pKi	=	8.8	Binding	Inhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 minInhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 min	ChEMBL	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	10.1021/jm00017a019
		DB00427	3866	34	None	5	4	Guinea pig	8.8	pKi	=	8.8	Binding	Inhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 minInhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 min	ChEMBL	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	10.1021/jm00017a019
		4011	82408	49	None	6	24	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	10.1016/j.bmcl.2008.09.012
		CHEMBL21731	82408	49	None	6	24	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	10.1016/j.bmcl.2008.09.012
		11702115	8304	2	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	297	5	0	3	3.1	CN(C)CCC1=C(Cc2cccnn2)c2ccc(F)cc2C1	10.1016/j.bmcl.2010.02.055
		CHEMBL1092662	8304	2	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	297	5	0	3	3.1	CN(C)CCC1=C(Cc2cccnn2)c2ccc(F)cc2C1	10.1016/j.bmcl.2010.02.055
		11695591	8321	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	328	5	0	3	4.7	C[C@H](c1cccnc1F)c1c(CCN(C)C)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		CHEMBL1092765	8321	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	328	5	0	3	4.7	C[C@H](c1cccnc1F)c1c(CCN(C)C)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		1227	2489	43	None	-2	12	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in HEK-293 cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in HEK-293 cells	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.ejmech.2014.12.045
		2331	2489	43	None	-2	12	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in HEK-293 cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in HEK-293 cells	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.ejmech.2014.12.045
		3957	2489	43	None	-2	12	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in HEK-293 cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in HEK-293 cells	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.ejmech.2014.12.045
		4992	2489	43	None	-2	12	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in HEK-293 cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in HEK-293 cells	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.ejmech.2014.12.045
		CHEMBL511	2489	43	None	-2	12	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in HEK-293 cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in HEK-293 cells	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.ejmech.2014.12.045
		DB06691	2489	43	None	-2	12	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in HEK-293 cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in HEK-293 cells	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.ejmech.2014.12.045
		1227	2489	43	None	-2	12	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]pyrilamine from human recombinant H1 receptor expressed in HEK293 cellsDisplacement of [3H]pyrilamine from human recombinant H1 receptor expressed in HEK293 cells	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm401895u
		2331	2489	43	None	-2	12	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]pyrilamine from human recombinant H1 receptor expressed in HEK293 cellsDisplacement of [3H]pyrilamine from human recombinant H1 receptor expressed in HEK293 cells	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm401895u
		3957	2489	43	None	-2	12	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]pyrilamine from human recombinant H1 receptor expressed in HEK293 cellsDisplacement of [3H]pyrilamine from human recombinant H1 receptor expressed in HEK293 cells	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm401895u
		4992	2489	43	None	-2	12	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]pyrilamine from human recombinant H1 receptor expressed in HEK293 cellsDisplacement of [3H]pyrilamine from human recombinant H1 receptor expressed in HEK293 cells	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm401895u
		CHEMBL511	2489	43	None	-2	12	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]pyrilamine from human recombinant H1 receptor expressed in HEK293 cellsDisplacement of [3H]pyrilamine from human recombinant H1 receptor expressed in HEK293 cells	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm401895u
		DB06691	2489	43	None	-2	12	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]pyrilamine from human recombinant H1 receptor expressed in HEK293 cellsDisplacement of [3H]pyrilamine from human recombinant H1 receptor expressed in HEK293 cells	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm401895u
		135	2532	43	None	-1	58	Human	8.8	pKi	=	8.8	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
		1796	2532	43	None	-1	58	Human	8.8	pKi	=	8.8	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
		4184	2532	43	None	-1	58	Human	8.8	pKi	=	8.8	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
		CHEMBL6437	2532	43	None	-1	58	Human	8.8	pKi	=	8.8	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
		DB06148	2532	43	None	-1	58	Human	8.8	pKi	=	8.8	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
		11702115	8304	2	None	-	1	Human	8.8	pKi	=	8.8	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	297	5	0	3	3.1	CN(C)CCC1=C(Cc2cccnn2)c2ccc(F)cc2C1	10.1016/j.bmcl.2010.07.117
		CHEMBL1092662	8304	2	None	-	1	Human	8.8	pKi	=	8.8	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	297	5	0	3	3.1	CN(C)CCC1=C(Cc2cccnn2)c2ccc(F)cc2C1	10.1016/j.bmcl.2010.07.117
		155539495	172846	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	394	4	0	2	6.2	CCC(CC)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/acs.jmedchem.9b00447
		CHEMBL4514700	172846	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	394	4	0	2	6.2	CCC(CC)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/acs.jmedchem.9b00447
		135398737	958	93	None	2	89	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2008.06.030
		38	958	93	None	2	89	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2008.06.030
		722	958	93	None	2	89	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2008.06.030
		CHEMBL42	958	93	None	2	89	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2008.06.030
		DB00363	958	93	None	2	89	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2008.06.030
		135398737	958	93	None	2	89	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]pyrilamine from human H1 receptor by liquid scintillation countingDisplacement of [3H]pyrilamine from human H1 receptor by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2011.12.019
		38	958	93	None	2	89	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]pyrilamine from human H1 receptor by liquid scintillation countingDisplacement of [3H]pyrilamine from human H1 receptor by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2011.12.019
		722	958	93	None	2	89	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]pyrilamine from human H1 receptor by liquid scintillation countingDisplacement of [3H]pyrilamine from human H1 receptor by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2011.12.019
		CHEMBL42	958	93	None	2	89	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]pyrilamine from human H1 receptor by liquid scintillation countingDisplacement of [3H]pyrilamine from human H1 receptor by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2011.12.019
		DB00363	958	93	None	2	89	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]pyrilamine from human H1 receptor by liquid scintillation countingDisplacement of [3H]pyrilamine from human H1 receptor by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2011.12.019
		45272875	195844	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	352	4	0	4	3.8	CN(C)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1	10.1016/j.bmcl.2009.05.086
		CHEMBL558467	195844	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	352	4	0	4	3.8	CN(C)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1	10.1016/j.bmcl.2009.05.086
		4098	32505	30	None	1	11	Human	8.7	pKi	=	8.7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
		CHEMBL1255739	32505	30	None	1	11	Human	8.7	pKi	=	8.7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
		CHEMBL1411979	32505	30	None	1	11	Human	8.7	pKi	=	8.7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
		44326125	111701	0	None	8	3	Human	8.7	pKi	=	8.7	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	455	4	0	3	5.9	O=C(c1ccc(F)cc1)C1CCN(CC2C[C@@H]3c4ccccc4Cc4ccccc4[C@H]3O2)CC1	10.1016/j.bmcl.2004.03.069
		CHEMBL328662	111701	0	None	8	3	Human	8.7	pKi	=	8.7	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	455	4	0	3	5.9	O=C(c1ccc(F)cc1)C1CCN(CC2C[C@@H]3c4ccccc4Cc4ccccc4[C@H]3O2)CC1	10.1016/j.bmcl.2004.03.069
		2726	919	68	None	-2	72	Human	8.7	pKi	=	8.7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		621	919	68	None	-2	72	Human	8.7	pKi	=	8.7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		83	919	68	None	-2	72	Human	8.7	pKi	=	8.7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		CHEMBL71	919	68	None	-2	72	Human	8.7	pKi	=	8.7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		DB00477	919	68	None	-2	72	Human	8.7	pKi	=	8.7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		134135966	154445	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	281	4	0	2	3.8	CN1CCC(Oc2ccccc2Cc2ccccc2)CC1	10.1021/acs.jmedchem.6b00981
		CHEMBL3906929	154445	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	281	4	0	2	3.8	CN1CCC(Oc2ccccc2Cc2ccccc2)CC1	10.1021/acs.jmedchem.6b00981
		CHEMBL3990109	154445	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	281	4	0	2	3.8	CN1CCC(Oc2ccccc2Cc2ccccc2)CC1	10.1021/acs.jmedchem.6b00981
		18715379	9143	0	None	-	1	Rat	8.0	pKi	=	8	Binding	Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.	ChEMBL	430	0	0	2	5.0	CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cc(Br)cnc32)CC1	10.1016/S0960-894X(00)80290-5
		CHEMBL11001	9143	0	None	-	1	Rat	8.0	pKi	=	8	Binding	Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.	ChEMBL	430	0	0	2	5.0	CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cc(Br)cnc32)CC1	10.1016/S0960-894X(00)80290-5
		10177103	171347	0	None	12	2	Rat	8.0	pKi	=	8	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	ChEMBL	368	9	1	3	4.5	CN(CCCc1c[nH]cn1)CCC(c1ccc(Cl)cc1)c1ccccn1	10.1016/s0960-894x(03)00357-3
		CHEMBL446147	171347	0	None	12	2	Rat	8.0	pKi	=	8	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	ChEMBL	368	9	1	3	4.5	CN(CCCc1c[nH]cn1)CCC(c1ccc(Cl)cc1)c1ccccn1	10.1016/s0960-894x(03)00357-3
		CHEMBL5291469	194640	0	None	70	2	Human	8.0	pKi	=	8	Binding	Antagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysisAntagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysis	ChEMBL	508	8	1	6	3.6	O=C(NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O)C1CCOCC1	10.1021/acsmedchemlett.7b00112
		CHEMBL5315702	194640	0	None	70	2	Human	8.0	pKi	=	8	Binding	Antagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysisAntagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysis	ChEMBL	508	8	1	6	3.6	O=C(NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O)C1CCOCC1	10.1021/acsmedchemlett.7b00112
		2337	3256	77	None	1	62	Human	8.0	pKi	=	8	Binding	Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		50	3256	77	None	1	62	Human	8.0	pKi	=	8	Binding	Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		5002	3256	77	None	1	62	Human	8.0	pKi	=	8	Binding	Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		CHEMBL716	3256	77	None	1	62	Human	8.0	pKi	=	8	Binding	Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		DB01224	3256	77	None	1	62	Human	8.0	pKi	=	8	Binding	Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		14127193	11286	0	None	-	1	Guinea pig	8.0	pKi	=	8	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	351	6	1	3	4.4	CCN(CC)CC/C=C1/c2ccccc2COc2ccc(C(=O)O)cc21	10.1021/jm00089a020
		CHEMBL1179179	11286	0	None	-	1	Guinea pig	8.0	pKi	=	8	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	351	6	1	3	4.4	CCN(CC)CC/C=C1/c2ccccc2COc2ccc(C(=O)O)cc21	10.1021/jm00089a020
		CHEMBL63596	11286	0	None	-	1	Guinea pig	8.0	pKi	=	8	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	351	6	1	3	4.4	CCN(CC)CC/C=C1/c2ccccc2COc2ccc(C(=O)O)cc21	10.1021/jm00089a020
		135398737	958	93	None	2	89	Human	8.0	pKi	=	8	Binding	Binding affinity to H1 histamine receptor (unknown origin) by PDSP assayBinding affinity to H1 histamine receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		38	958	93	None	2	89	Human	8.0	pKi	=	8	Binding	Binding affinity to H1 histamine receptor (unknown origin) by PDSP assayBinding affinity to H1 histamine receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		722	958	93	None	2	89	Human	8.0	pKi	=	8	Binding	Binding affinity to H1 histamine receptor (unknown origin) by PDSP assayBinding affinity to H1 histamine receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		CHEMBL42	958	93	None	2	89	Human	8.0	pKi	=	8	Binding	Binding affinity to H1 histamine receptor (unknown origin) by PDSP assayBinding affinity to H1 histamine receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		DB00363	958	93	None	2	89	Human	8.0	pKi	=	8	Binding	Binding affinity to H1 histamine receptor (unknown origin) by PDSP assayBinding affinity to H1 histamine receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		135398745	2914	112	None	1	65	Human	8.0	pKi	=	8	Binding	Binding affinity to H1 histamine receptor (unknown origin) by PDSP assayBinding affinity to H1 histamine receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
		47	2914	112	None	1	65	Human	8.0	pKi	=	8	Binding	Binding affinity to H1 histamine receptor (unknown origin) by PDSP assayBinding affinity to H1 histamine receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
		CHEMBL715	2914	112	None	1	65	Human	8.0	pKi	=	8	Binding	Binding affinity to H1 histamine receptor (unknown origin) by PDSP assayBinding affinity to H1 histamine receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
		DB00334	2914	112	None	1	65	Human	8.0	pKi	=	8	Binding	Binding affinity to H1 histamine receptor (unknown origin) by PDSP assayBinding affinity to H1 histamine receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
		2337	3256	77	None	1	62	Human	8.0	pKi	=	8	Binding	Binding affinity to H1 histamine receptor (unknown origin) by PDSP assayBinding affinity to H1 histamine receptor (unknown origin) by PDSP assay	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1039/C2MD00311B
		50	3256	77	None	1	62	Human	8.0	pKi	=	8	Binding	Binding affinity to H1 histamine receptor (unknown origin) by PDSP assayBinding affinity to H1 histamine receptor (unknown origin) by PDSP assay	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1039/C2MD00311B
		5002	3256	77	None	1	62	Human	8.0	pKi	=	8	Binding	Binding affinity to H1 histamine receptor (unknown origin) by PDSP assayBinding affinity to H1 histamine receptor (unknown origin) by PDSP assay	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1039/C2MD00311B
		CHEMBL716	3256	77	None	1	62	Human	8.0	pKi	=	8	Binding	Binding affinity to H1 histamine receptor (unknown origin) by PDSP assayBinding affinity to H1 histamine receptor (unknown origin) by PDSP assay	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1039/C2MD00311B
		DB01224	3256	77	None	1	62	Human	8.0	pKi	=	8	Binding	Binding affinity to H1 histamine receptor (unknown origin) by PDSP assayBinding affinity to H1 histamine receptor (unknown origin) by PDSP assay	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1039/C2MD00311B
		1427	2013	54	None	-5	27	Human	8.0	pKi	=	8	Binding	Binding affinity to H1 receptor (unknown origin)Binding affinity to H1 receptor (unknown origin)	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1016/j.bmcl.2020.127493
		357	2013	54	None	-5	27	Human	8.0	pKi	=	8	Binding	Binding affinity to H1 receptor (unknown origin)Binding affinity to H1 receptor (unknown origin)	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1016/j.bmcl.2020.127493
		3696	2013	54	None	-5	27	Human	8.0	pKi	=	8	Binding	Binding affinity to H1 receptor (unknown origin)Binding affinity to H1 receptor (unknown origin)	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1016/j.bmcl.2020.127493
		CHEMBL11	2013	54	None	-5	27	Human	8.0	pKi	=	8	Binding	Binding affinity to H1 receptor (unknown origin)Binding affinity to H1 receptor (unknown origin)	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1016/j.bmcl.2020.127493
		DB00458	2013	54	None	-5	27	Human	8.0	pKi	=	8	Binding	Binding affinity to H1 receptor (unknown origin)Binding affinity to H1 receptor (unknown origin)	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1016/j.bmcl.2020.127493
		1524	2181	96	None	-2	52	Guinea pig	8.0	pKi	=	8	Binding	Binding affinity to guinea pig cerebellum homogenate membrane H1 receptor incubated for 30 minsBinding affinity to guinea pig cerebellum homogenate membrane H1 receptor incubated for 30 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/acs.jmedchem.2c00633
		197	2181	96	None	-2	52	Guinea pig	8.0	pKi	=	8	Binding	Binding affinity to guinea pig cerebellum homogenate membrane H1 receptor incubated for 30 minsBinding affinity to guinea pig cerebellum homogenate membrane H1 receptor incubated for 30 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/acs.jmedchem.2c00633
		3822	2181	96	None	-2	52	Guinea pig	8.0	pKi	=	8	Binding	Binding affinity to guinea pig cerebellum homogenate membrane H1 receptor incubated for 30 minsBinding affinity to guinea pig cerebellum homogenate membrane H1 receptor incubated for 30 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/acs.jmedchem.2c00633
		88	2181	96	None	-2	52	Guinea pig	8.0	pKi	=	8	Binding	Binding affinity to guinea pig cerebellum homogenate membrane H1 receptor incubated for 30 minsBinding affinity to guinea pig cerebellum homogenate membrane H1 receptor incubated for 30 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/acs.jmedchem.2c00633
		CHEMBL51	2181	96	None	-2	52	Guinea pig	8.0	pKi	=	8	Binding	Binding affinity to guinea pig cerebellum homogenate membrane H1 receptor incubated for 30 minsBinding affinity to guinea pig cerebellum homogenate membrane H1 receptor incubated for 30 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/acs.jmedchem.2c00633
		DB12465	2181	96	None	-2	52	Guinea pig	8.0	pKi	=	8	Binding	Binding affinity to guinea pig cerebellum homogenate membrane H1 receptor incubated for 30 minsBinding affinity to guinea pig cerebellum homogenate membrane H1 receptor incubated for 30 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/acs.jmedchem.2c00633
		69260079	81306	2	None	63	2	Human	8.0	pKi	=	8	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	463	6	1	5	4.8	O=C(O)c1cccnc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158834	81306	2	None	63	2	Human	8.0	pKi	=	8	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	463	6	1	5	4.8	O=C(O)c1cccnc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		17867053	99010	0	None	10	3	Rat	8.0	pKi	=	8	Binding	Displacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptorDisplacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptor	ChEMBL	435	5	0	5	4.3	Cn1c(=O)sc2cc(CCN3CCN(Cc4ccc(Cl)cc4Cl)CC3)ccc21	10.1016/s0960-894x(02)00123-3
		CHEMBL280063	99010	0	None	10	3	Rat	8.0	pKi	=	8	Binding	Displacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptorDisplacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptor	ChEMBL	435	5	0	5	4.3	Cn1c(=O)sc2cc(CCN3CCN(Cc4ccc(Cl)cc4Cl)CC3)ccc21	10.1016/s0960-894x(02)00123-3
		59296066	84093	0	None	-5	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	487	7	3	5	3.0	Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)cc2C(F)(F)F)CC1	10.1016/j.bmcl.2012.09.112
		CHEMBL2207663	84093	0	None	-5	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	487	7	3	5	3.0	Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)cc2C(F)(F)F)CC1	10.1016/j.bmcl.2012.09.112
		59295938	84094	0	None	-7	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	521	7	3	5	3.6	Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)cc3C(F)(F)F)CC2)c1Cl	10.1016/j.bmcl.2012.09.112
		CHEMBL2207664	84094	0	None	-7	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	521	7	3	5	3.6	Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)cc3C(F)(F)F)CC2)c1Cl	10.1016/j.bmcl.2012.09.112
		11335419	67100	1	None	11	6	Human	8.0	pKi	=	8	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	295	7	0	2	4.1	c1ccc(Cc2ccccc2OCCCN2CCCC2)cc1	10.1021/acs.jmedchem.6b00981
		CHEMBL187367	67100	1	None	11	6	Human	8.0	pKi	=	8	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	295	7	0	2	4.1	c1ccc(Cc2ccccc2OCCCN2CCCC2)cc1	10.1021/acs.jmedchem.6b00981
		15662541	67772	0	None	-	1	Guinea pig	8.0	pKi	=	8	Binding	Inhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 minInhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 min	ChEMBL	322	2	0	3	4.8	c1ccc2c(c1)Sc1ccccc1N2CC12CCN(CC1)CC2	10.1021/jm00017a019
		CHEMBL1908311	67772	0	None	-	1	Guinea pig	8.0	pKi	=	8	Binding	Inhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 minInhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 min	ChEMBL	322	2	0	3	4.8	c1ccc2c(c1)Sc1ccccc1N2CC12CCN(CC1)CC2	10.1021/jm00017a019
		44450154	95836	0	None	-	1	Human	8.0	pKi	=	8	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	311	4	1	4	2.7	c1ccc([C@@H](Oc2cccc3c2OCC3)[C@H]2CNCCO2)cc1	10.1016/j.bmcl.2008.03.050
		CHEMBL258930	95836	0	None	-	1	Human	8.0	pKi	=	8	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	311	4	1	4	2.7	c1ccc([C@@H](Oc2cccc3c2OCC3)[C@H]2CNCCO2)cc1	10.1016/j.bmcl.2008.03.050
		44449768	96023	0	None	-	1	Human	8.0	pKi	=	8	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	317	5	1	4	2.9	COc1cc(F)ccc1O[C@H](c1ccccc1)[C@H]1CNCCO1	10.1016/j.bmcl.2008.03.050
		CHEMBL259765	96023	0	None	-	1	Human	8.0	pKi	=	8	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	317	5	1	4	2.9	COc1cc(F)ccc1O[C@H](c1ccccc1)[C@H]1CNCCO1	10.1016/j.bmcl.2008.03.050
		44450212	96219	0	None	-	1	Human	8.0	pKi	=	8	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	321	4	1	3	3.6	Fc1ccc(O[C@H](c2ccccc2)[C@H]2CNCCO2)c(Cl)c1	10.1016/j.bmcl.2008.03.050
		CHEMBL260823	96219	0	None	-	1	Human	8.0	pKi	=	8	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	321	4	1	3	3.6	Fc1ccc(O[C@H](c2ccccc2)[C@H]2CNCCO2)c(Cl)c1	10.1016/j.bmcl.2008.03.050
		44450181	96743	0	None	-	1	Human	8.0	pKi	=	8	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	305	4	1	3	3.1	Fc1cccc(O[C@H](c2ccccc2)[C@H]2CNCCO2)c1F	10.1016/j.bmcl.2008.03.050
		CHEMBL264418	96743	0	None	-	1	Human	8.0	pKi	=	8	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	305	4	1	3	3.1	Fc1cccc(O[C@H](c2ccccc2)[C@H]2CNCCO2)c1F	10.1016/j.bmcl.2008.03.050
		44450184	155676	0	None	-	1	Human	8.0	pKi	=	8	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	301	4	1	3	3.2	Cc1cc(F)ccc1O[C@H](c1ccccc1)[C@H]1CNCCO1	10.1016/j.bmcl.2008.03.050
		CHEMBL404956	155676	0	None	-	1	Human	8.0	pKi	=	8	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	301	4	1	3	3.2	Cc1cc(F)ccc1O[C@H](c1ccccc1)[C@H]1CNCCO1	10.1016/j.bmcl.2008.03.050
		10458170	116526	0	None	-	1	Guinea pig	8.0	pKi	=	8	Binding	Inhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptorInhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptor	ChEMBL	487	8	1	4	6.0	O=C(O)Cc1ccc2c(c1)C(SCCN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2	10.1021/jm00055a013
		CHEMBL336198	116526	0	None	-	1	Guinea pig	8.0	pKi	=	8	Binding	Inhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptorInhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptor	ChEMBL	487	8	1	4	6.0	O=C(O)Cc1ccc2c(c1)C(SCCN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2	10.1021/jm00055a013
		51039227	57760	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	323	5	0	3	3.5	FC1CCN(CCC2=C(Cc3cnccn3)c3ccccc3C2)C1	10.1016/j.bmcl.2010.12.053
		CHEMBL1669417	57760	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	323	5	0	3	3.5	FC1CCN(CCC2=C(Cc3cnccn3)c3ccccc3C2)C1	10.1016/j.bmcl.2010.12.053
		22621911	9408	0	None	-	1	Rat	7.0	pKi	=	7	Binding	Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.	ChEMBL	386	0	0	2	4.9	CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cc(Cl)cnc32)CC1	10.1016/S0960-894X(00)80290-5
		CHEMBL11159	9408	0	None	-	1	Rat	7.0	pKi	=	7	Binding	Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.	ChEMBL	386	0	0	2	4.9	CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cc(Cl)cnc32)CC1	10.1016/S0960-894X(00)80290-5
		242	470	124	None	-22	51	Human	7.0	pKi	=	7	Binding	Binding affinity to H1 histamine receptor (unknown origin) by PDSP assayBinding affinity to H1 histamine receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
		34	470	124	None	-22	51	Human	7.0	pKi	=	7	Binding	Binding affinity to H1 histamine receptor (unknown origin) by PDSP assayBinding affinity to H1 histamine receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
		60795	470	124	None	-22	51	Human	7.0	pKi	=	7	Binding	Binding affinity to H1 histamine receptor (unknown origin) by PDSP assayBinding affinity to H1 histamine receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
		CHEMBL1112	470	124	None	-22	51	Human	7.0	pKi	=	7	Binding	Binding affinity to H1 histamine receptor (unknown origin) by PDSP assayBinding affinity to H1 histamine receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
		DB01238	470	124	None	-22	51	Human	7.0	pKi	=	7	Binding	Binding affinity to H1 histamine receptor (unknown origin) by PDSP assayBinding affinity to H1 histamine receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
		2389	3331	118	None	-46	67	Human	7.0	pKi	=	7	Binding	Binding affinity to H1 histamine receptor (unknown origin) by PDSP assayBinding affinity to H1 histamine receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
		5073	3331	118	None	-46	67	Human	7.0	pKi	=	7	Binding	Binding affinity to H1 histamine receptor (unknown origin) by PDSP assayBinding affinity to H1 histamine receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
		96	3331	118	None	-46	67	Human	7.0	pKi	=	7	Binding	Binding affinity to H1 histamine receptor (unknown origin) by PDSP assayBinding affinity to H1 histamine receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
		CHEMBL85	3331	118	None	-46	67	Human	7.0	pKi	=	7	Binding	Binding affinity to H1 histamine receptor (unknown origin) by PDSP assayBinding affinity to H1 histamine receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
		DB00734	3331	118	None	-46	67	Human	7.0	pKi	=	7	Binding	Binding affinity to H1 histamine receptor (unknown origin) by PDSP assayBinding affinity to H1 histamine receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
		66615705	81267	0	None	-19	2	Human	7.0	pKi	=	7	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	508	8	1	4	5.4	O=C(O)[C@H](Cc1ccc(F)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)cc3Cl)CC2)CC1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158779	81267	0	None	-19	2	Human	7.0	pKi	=	7	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	508	8	1	4	5.4	O=C(O)[C@H](Cc1ccc(F)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)cc3Cl)CC2)CC1	10.1016/j.bmcl.2012.08.103
		71453204	81270	0	None	-12	2	Human	7.0	pKi	=	7	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	488	8	1	4	5.0	Cc1cc(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc1Cl	10.1016/j.bmcl.2012.08.103
		CHEMBL2158782	81270	0	None	-12	2	Human	7.0	pKi	=	7	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	488	8	1	4	5.0	Cc1cc(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc1Cl	10.1016/j.bmcl.2012.08.103
		71451392	81274	0	None	-31	2	Human	7.0	pKi	=	7	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	504	8	1	4	5.6	C[C@](Cc1ccccc1)(C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158786	81274	0	None	-31	2	Human	7.0	pKi	=	7	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	504	8	1	4	5.6	C[C@](Cc1ccccc1)(C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		68849581	81289	0	None	-3	2	Human	7.0	pKi	=	7	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	478	7	1	5	4.4	O=C(O)C(c1ccccc1)N1CCO[C@H](CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)C1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158818	81289	0	None	-3	2	Human	7.0	pKi	=	7	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	478	7	1	5	4.4	O=C(O)C(c1ccccc1)N1CCO[C@H](CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)C1	10.1016/j.bmcl.2012.08.103
		69347575	81292	0	None	-10	2	Human	7.0	pKi	=	7	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	476	7	1	4	5.4	O=C(O)[C@@H](c1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158821	81292	0	None	-10	2	Human	7.0	pKi	=	7	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	476	7	1	4	5.4	O=C(O)[C@@H](c1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		71072034	81308	0	None	-3	2	Human	7.0	pKi	=	7	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	490	8	1	4	5.2	O=C(O)[C@@H](Cc1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158836	81308	0	None	-3	2	Human	7.0	pKi	=	7	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	490	8	1	4	5.2	O=C(O)[C@@H](Cc1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		127036932	137348	0	None	-3	22	Human	7.0	pKi	=	7	Binding	Binding affinity to histamine H1 receptor (unknown origin) by competition binding assayBinding affinity to histamine H1 receptor (unknown origin) by competition binding assay	ChEMBL	274	7	1	1	4.0	C=CCN(CC=C)CCc1c[nH]c2ccc(Cl)cc12	10.1016/j.bmcl.2015.12.053
		CHEMBL3752900	137348	0	None	-3	22	Human	7.0	pKi	=	7	Binding	Binding affinity to histamine H1 receptor (unknown origin) by competition binding assayBinding affinity to histamine H1 receptor (unknown origin) by competition binding assay	ChEMBL	274	7	1	1	4.0	C=CCN(CC=C)CCc1c[nH]c2ccc(Cl)cc12	10.1016/j.bmcl.2015.12.053
		127036953	137515	0	None	-10	22	Human	7.0	pKi	=	7	Binding	Binding affinity to histamine H1 receptor (unknown origin) by competition binding assayBinding affinity to histamine H1 receptor (unknown origin) by competition binding assay	ChEMBL	318	7	1	1	4.1	C=CCN(CC=C)CCc1c[nH]c2ccc(Br)cc12	10.1016/j.bmcl.2015.12.053
		CHEMBL3754166	137515	0	None	-10	22	Human	7.0	pKi	=	7	Binding	Binding affinity to histamine H1 receptor (unknown origin) by competition binding assayBinding affinity to histamine H1 receptor (unknown origin) by competition binding assay	ChEMBL	318	7	1	1	4.1	C=CCN(CC=C)CCc1c[nH]c2ccc(Br)cc12	10.1016/j.bmcl.2015.12.053
		59296085	84209	0	None	2	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	506	8	2	7	3.1	CS(=O)(=O)c1ccc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)s1	10.1016/j.bmcl.2012.09.113
		CHEMBL2208426	84209	0	None	2	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	506	8	2	7	3.1	CS(=O)(=O)c1ccc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)s1	10.1016/j.bmcl.2012.09.113
		57397301	67880	0	None	-13	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	560	11	1	6	4.6	COc1ccc(CN(CCN(C)CCN2CCN(C(=O)c3cc4cc(Cl)ccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		CHEMBL1910382	67880	0	None	-13	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	560	11	1	6	4.6	COc1ccc(CN(CCN(C)CCN2CCN(C(=O)c3cc4cc(Cl)ccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		12660328	13406	16	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	241	6	1	2	2.9	CNCCOc1ccccc1Cc1ccccc1	10.1021/acs.jmedchem.6b00981
		CHEMBL1192719	13406	16	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	241	6	1	2	2.9	CNCCOc1ccccc1Cc1ccccc1	10.1021/acs.jmedchem.6b00981
		CHEMBL3953343	13406	16	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	241	6	1	2	2.9	CNCCOc1ccccc1Cc1ccccc1	10.1021/acs.jmedchem.6b00981
		242	470	124	None	-23	51	Guinea pig	7.0	pKi	=	7	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm070516u
		34	470	124	None	-23	51	Guinea pig	7.0	pKi	=	7	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm070516u
		60795	470	124	None	-23	51	Guinea pig	7.0	pKi	=	7	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm070516u
		CHEMBL1112	470	124	None	-23	51	Guinea pig	7.0	pKi	=	7	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm070516u
		DB01238	470	124	None	-23	51	Guinea pig	7.0	pKi	=	7	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm070516u
		23102733	82233	0	None	-1	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	511	6	1	5	4.0	O=C(NS(=O)(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1)c1ccccc1	10.1016/j.bmcl.2012.08.124
		CHEMBL2171015	82233	0	None	-1	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	511	6	1	5	4.0	O=C(NS(=O)(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1)c1ccccc1	10.1016/j.bmcl.2012.08.124
		71458869	82241	0	None	2	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	506	7	1	5	4.6	O=C(O)COc1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1	10.1016/j.bmcl.2012.08.124
		CHEMBL2171022	82241	0	None	2	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	506	7	1	5	4.6	O=C(O)COc1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1	10.1016/j.bmcl.2012.08.124
		11709314	104111	0	None	-100	2	Human	6.0	pKi	=	6	Binding	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced effect by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced effect by FLIPR assay	ChEMBL	307	5	0	2	4.1	c1ccc(COc2ccc3c(c2)CCN(CC2CC2)CC3)cc1	10.1016/j.bmcl.2013.09.089
		CHEMBL3094114	104111	0	None	-100	2	Human	6.0	pKi	=	6	Binding	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced effect by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced effect by FLIPR assay	ChEMBL	307	5	0	2	4.1	c1ccc(COc2ccc3c(c2)CCN(CC2CC2)CC3)cc1	10.1016/j.bmcl.2013.09.089
		10067368	104132	0	None	-100	2	Human	6.0	pKi	=	6	Binding	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced effect by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced effect by FLIPR assay	ChEMBL	364	6	0	3	4.5	c1ccc(N2CCc3ccc(OCCCN4CCCCC4)cc3CC2)cc1	10.1016/j.bmcl.2013.09.089
		CHEMBL3094214	104132	0	None	-100	2	Human	6.0	pKi	=	6	Binding	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced effect by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced effect by FLIPR assay	ChEMBL	364	6	0	3	4.5	c1ccc(N2CCc3ccc(OCCCN4CCCCC4)cc3CC2)cc1	10.1016/j.bmcl.2013.09.089
		10064805	102376	0	None	-54	4	Human	6.0	pKi	=	6	Binding	Compound was tested for its binding affinity towards human H1 receptorCompound was tested for its binding affinity towards human H1 receptor	ChEMBL	323	4	1	3	4.4	CN1CCCC1CCNc1c2c(nc3ccccc13)CCCCC2	10.1016/s0960-894x(03)00356-1
		CHEMBL303824	102376	0	None	-54	4	Human	6.0	pKi	=	6	Binding	Compound was tested for its binding affinity towards human H1 receptorCompound was tested for its binding affinity towards human H1 receptor	ChEMBL	323	4	1	3	4.4	CN1CCCC1CCNc1c2c(nc3ccccc13)CCCCC2	10.1016/s0960-894x(03)00356-1
		33630	178957	99	None	-13	28	Human	6.0	pKi	=	6	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]Pyrilamine from human H1 receptor expressed in HEK cells by radioligand binding assay	ChEMBL	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		CHEMBL47050	178957	99	None	-13	28	Human	6.0	pKi	=	6	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]Pyrilamine from human H1 receptor expressed in HEK cells by radioligand binding assay	ChEMBL	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		71454295	84079	0	None	-1258	7	Human	6.0	pKi	=	6	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation counting analysisDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation counting analysis	ChEMBL	536	8	0	6	5.5	COc1ccccc1N1CCN(Cc2cc(CN3CCN(c4ccccc4OC)CC3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		CHEMBL2207641	84079	0	None	-1258	7	Human	6.0	pKi	=	6	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation counting analysisDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation counting analysis	ChEMBL	536	8	0	6	5.5	COc1ccccc1N1CCN(Cc2cc(CN3CCN(c4ccccc4OC)CC3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		17963199	82270	0	None	-1	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	493	5	1	5	3.7	Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(F)c(F)c4)CC3)CC2)cc1	10.1016/j.bmcl.2012.08.124
		CHEMBL2171050	82270	0	None	-1	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	493	5	1	5	3.7	Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(F)c(F)c4)CC3)CC2)cc1	10.1016/j.bmcl.2012.08.124
		25025581	201996	0	None	-15	8	Human	6.0	pKi	=	6	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	285	4	1	2	3.1	CCOC[C@H]1[C@@H]2CNC[C@@]21c1ccc(Cl)c(Cl)c1	10.1021/jm901818u
		CHEMBL608151	201996	0	None	-15	8	Human	6.0	pKi	=	6	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	285	4	1	2	3.1	CCOC[C@H]1[C@@H]2CNC[C@@]21c1ccc(Cl)c(Cl)c1	10.1021/jm901818u
		10060425	54935	0	None	-758	2	Guinea pig	5.0	pKi	=	5	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	245	5	2	3	2.6	O=C(Nc1ccccc1)OCCCc1c[nH]cn1	10.1021/jm9507688
		CHEMBL16142	54935	0	None	-758	2	Guinea pig	5.0	pKi	=	5	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	245	5	2	3	2.6	O=C(Nc1ccccc1)OCCCc1c[nH]cn1	10.1021/jm9507688
		14554146	119119	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	354	0	0	2	3.9	CC(=O)N1CCC(=C2c3cc(F)c(F)cc3CCc3cccnc32)CC1	10.1021/jm00105a069
		CHEMBL342747	119119	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	354	0	0	2	3.9	CC(=O)N1CCC(=C2c3cc(F)c(F)cc3CCc3cccnc32)CC1	10.1021/jm00105a069
		44334265	109683	0	None	-50	3	Human	5.0	pKi	=	5	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	368	8	1	6	2.0	CC(=O)c1ccc(OCCCN2CC[C@H](NC(=O)c3cnccn3)C2)cc1	10.1016/s0960-894x(02)00685-6
		CHEMBL322695	109683	0	None	-50	3	Human	5.0	pKi	=	5	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	368	8	1	6	2.0	CC(=O)c1ccc(OCCCN2CC[C@H](NC(=O)c3cnccn3)C2)cc1	10.1016/s0960-894x(02)00685-6
		44304295	202869	0	None	-2290	3	Human	5.0	pKi	=	5	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	357	8	1	5	1.5	O=C1C[C@@H](N2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)CC2)N1	10.1016/s0960-894x(02)00310-4
		CHEMBL62596	202869	0	None	-2290	3	Human	5.0	pKi	=	5	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	357	8	1	5	1.5	O=C1C[C@@H](N2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)CC2)N1	10.1016/s0960-894x(02)00310-4
		44304331	203121	0	None	-2187	3	Human	5.0	pKi	=	5	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	449	11	1	5	3.2	N[C@H](CCc1ccccc1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		CHEMBL64059	203121	0	None	-2187	3	Human	5.0	pKi	=	5	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	449	11	1	5	3.2	N[C@H](CCc1ccccc1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		44304303	203329	0	None	-776	3	Human	5.0	pKi	=	5	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	371	8	1	5	1.6	O=C(c1ccc(OCCCN2CCN(C(=O)[C@@H]3CCN3)CC2)cc1)C1CC1	10.1016/s0960-894x(02)00310-4
		CHEMBL64896	203329	0	None	-776	3	Human	5.0	pKi	=	5	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	371	8	1	5	1.6	O=C(c1ccc(OCCCN2CCN(C(=O)[C@@H]3CCN3)CC2)cc1)C1CC1	10.1016/s0960-894x(02)00310-4
		26191740	151582	9	None	-	1	Human	5.0	pKi	=	5	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	267	4	1	2	3.4	c1ccc(Cc2ccc(OC3CCNCC3)cc2)cc1	10.1021/acs.jmedchem.6b00981
		CHEMBL3963375	151582	9	None	-	1	Human	5.0	pKi	=	5	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	267	4	1	2	3.4	c1ccc(Cc2ccc(OC3CCNCC3)cc2)cc1	10.1021/acs.jmedchem.6b00981
		11623756	8142	0	None	-	1	Human	5.0	pKi	=	5	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	310	5	0	3	4.6	CC(c1cccnc1)c1c(CCN(C)C)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		CHEMBL1091776	8142	0	None	-	1	Human	5.0	pKi	=	5	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	310	5	0	3	4.6	CC(c1cccnc1)c1c(CCN(C)C)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		10731042	98650	0	None	-194	2	Guinea pig	4.0	pKi	=	4	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	274	6	3	4	1.9	Nc1ccc(CNC(=O)OCCCc2c[nH]cn2)cc1	10.1021/jm9507688
		CHEMBL277285	98650	0	None	-194	2	Guinea pig	4.0	pKi	=	4	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	274	6	3	4	1.9	Nc1ccc(CNC(=O)OCCCc2c[nH]cn2)cc1	10.1021/jm9507688
		44304311	200293	0	None	-17378	3	Human	4.0	pKi	=	4	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	442	10	1	7	2.2	N[C@H](Cc1nccs1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		CHEMBL59733	200293	0	None	-17378	3	Human	4.0	pKi	=	4	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	442	10	1	7	2.2	N[C@H](Cc1nccs1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		44304067	201283	0	None	-43651	3	Human	4.0	pKi	=	4	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	359	9	1	5	1.4	CNCC(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		CHEMBL60401	201283	0	None	-43651	3	Human	4.0	pKi	=	4	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	359	9	1	5	1.4	CNCC(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		44334521	107836	0	None	-85	3	Human	4.0	pKi	=	4	Binding	Binding affinity towards human Histamine H1 receptor (For compound 11)Binding affinity towards human Histamine H1 receptor (For compound 11)	ChEMBL	262	6	1	4	1.7	CC(=O)c1ccc(OCCCN2CC[C@H](N)C2)cc1	10.1016/s0960-894x(02)00685-6
		CHEMBL319231	107836	0	None	-85	3	Human	4.0	pKi	=	4	Binding	Binding affinity towards human Histamine H1 receptor (For compound 11)Binding affinity towards human Histamine H1 receptor (For compound 11)	ChEMBL	262	6	1	4	1.7	CC(=O)c1ccc(OCCCN2CC[C@H](N)C2)cc1	10.1016/s0960-894x(02)00685-6
		118709751	113541	0	None	-776	10	Human	6.0	pKi	=	6	Binding	Displacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation countingDisplacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccccc1F	10.1016/j.bmcl.2014.07.018
		CHEMBL3321792	113541	0	None	-776	10	Human	6.0	pKi	=	6	Binding	Displacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation countingDisplacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccccc1F	10.1016/j.bmcl.2014.07.018
		46882664	5717	0	None	-2	5	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	494	8	2	8	3.6	CCOc1cc(CN2CCC(Nc3nc4cc(Cl)c(S(N)(=O)=O)cc4o3)CC2)ccc1OC	10.1016/j.bmcl.2009.09.024
		CHEMBL1078240	5717	0	None	-2	5	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	494	8	2	8	3.6	CCOc1cc(CN2CCC(Nc3nc4cc(Cl)c(S(N)(=O)=O)cc4o3)CC2)ccc1OC	10.1016/j.bmcl.2009.09.024
		11545813	181194	0	None	-24	7	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	400	6	0	3	5.2	O=C(CCCN1C2CCC1CN(c1ccc(Cl)cc1)CC2)c1ccc(F)cc1	10.1016/j.bmc.2008.06.030
		CHEMBL476109	181194	0	None	-24	7	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	400	6	0	3	5.2	O=C(CCCN1C2CCC1CN(c1ccc(Cl)cc1)CC2)c1ccc(F)cc1	10.1016/j.bmc.2008.06.030
		168284748	191648	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	742	19	6	8	1.7	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5196026	191648	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	742	19	6	8	1.7	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		44304308	102485	0	None	-40	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	432	8	0	5	3.7	CCOC(=O)N1CCN(CCCOc2ccc(C(=O)c3cccc(F)c3F)cc2)CC1	10.1016/s0960-894x(02)00309-8
		CHEMBL304027	102485	0	None	-40	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	432	8	0	5	3.7	CCOC(=O)N1CCN(CCCOc2ccc(C(=O)c3cccc(F)c3F)cc2)CC1	10.1016/s0960-894x(02)00309-8
		168284748	191648	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	742	19	6	8	1.7	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5196026	191648	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	742	19	6	8	1.7	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		44304357	200610	0	None	-851	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	415	9	1	5	3.0	CC(C)(C)C[C@@H](N)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		CHEMBL59931	200610	0	None	-851	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	415	9	1	5	3.0	CC(C)(C)C[C@@H](N)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		164614907	184584	0	None	-323	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	378	6	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccc(F)cc1	10.1016/j.ejmech.2021.113190
		CHEMBL4848697	184584	0	None	-323	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	378	6	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccc(F)cc1	10.1016/j.ejmech.2021.113190
		44267109	7171	0	None	-	1	Rat	6.0	pKi	=	6.0	Binding	Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.	ChEMBL	366	0	0	2	4.6	CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3ccc(C)nc32)CC1	10.1016/S0960-894X(00)80290-5
		CHEMBL10855	7171	0	None	-	1	Rat	6.0	pKi	=	6.0	Binding	Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.	ChEMBL	366	0	0	2	4.6	CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3ccc(C)nc32)CC1	10.1016/S0960-894X(00)80290-5
		21830793	91835	10	None	-6760	45	Human	6.0	pKi	=	6.0	Binding	Binding affinity to histamine H1 receptor (unknown origin)Binding affinity to histamine H1 receptor (unknown origin)	ChEMBL	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	10.1016/j.bmc.2013.05.050
		CHEMBL2413154	91835	10	None	-6760	45	Human	6.0	pKi	=	6.0	Binding	Binding affinity to histamine H1 receptor (unknown origin)Binding affinity to histamine H1 receptor (unknown origin)	ChEMBL	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	10.1016/j.bmc.2013.05.050
		44304246	202651	0	None	-12	3	Human	7.0	pKi	=	7.0	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	426	11	0	5	4.6	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3occc3C)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL61396	202651	0	None	-12	3	Human	7.0	pKi	=	7.0	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	426	11	0	5	4.6	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3occc3C)CC2)cc1	10.1016/s0960-894x(02)00309-8
		44304310	203274	0	None	-141	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	415	10	0	4	4.1	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)N3CCCC3)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL64667	203274	0	None	-141	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	415	10	0	4	4.1	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)N3CCCC3)CC2)cc1	10.1016/s0960-894x(02)00309-8
		168281746	192882	0	None	-14454	6	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	365	6	4	5	1.6	CC(NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1cccc(F)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5184911	192882	0	None	-14454	6	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	365	6	4	5	1.6	CC(NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1cccc(F)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221974	192882	0	None	-14454	6	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	365	6	4	5	1.6	CC(NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1cccc(F)c1	10.1021/acs.jmedchem.1c00692
		71712245	110310	0	None	-43651	2	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	377	7	0	6	3.9	Cc1nnc(-c2cccnc2)n1-c1ccc(OCCCN2CCCCC2)cc1	10.1016/j.ejmech.2014.03.014
		CHEMBL3238445	110310	0	None	-43651	2	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	377	7	0	6	3.9	Cc1nnc(-c2cccnc2)n1-c1ccc(OCCCN2CCCCC2)cc1	10.1016/j.ejmech.2014.03.014
		56835171	69740	0	None	-645	9	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human H1 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H1 receptor expressed in HEK cell membranes	ChEMBL	295	2	2	6	1.9	Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935574	69740	0	None	-645	9	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human H1 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H1 receptor expressed in HEK cell membranes	ChEMBL	295	2	2	6	1.9	Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1	10.1016/j.bmcl.2011.10.104
		132060752	162926	0	None	-3	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-Pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	437	7	0	6	3.4	CCOC(=O)CCN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1	10.1016/j.ejmech.2018.02.024
		CHEMBL4174189	162926	0	None	-3	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-Pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	437	7	0	6	3.4	CCOC(=O)CCN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1	10.1016/j.ejmech.2018.02.024
		44304457	203213	0	None	-354	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	376	10	0	5	3.6	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)OC)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL64408	203213	0	None	-354	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	376	10	0	5	3.6	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)OC)CC2)cc1	10.1016/s0960-894x(02)00309-8
		127026017	137358	0	None	12	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	415	5	1	6	3.6	COc1ccc(CNc2nc3c(c(N4CCN(C)CC4)n2)-c2ccccc2CC3)cc1	10.1016/j.bmcl.2015.12.035
		CHEMBL3752972	137358	0	None	12	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	415	5	1	6	3.6	COc1ccc(CNc2nc3c(c(N4CCN(C)CC4)n2)-c2ccccc2CC3)cc1	10.1016/j.bmcl.2015.12.035
		12192007	168408	44	None	-407	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	191	2	2	2	0.8	N[C@@H](C(=O)O)C1Cc2ccccc2C1	10.1016/s0960-894x(02)00310-4
		CHEMBL434785	168408	44	None	-407	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	191	2	2	2	0.8	N[C@@H](C(=O)O)C1Cc2ccccc2C1	10.1016/s0960-894x(02)00310-4
		168275750	192826	0	None	-72	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	332	6	3	4	1.6	Cc1nnc(CCCN/C(N)=N/C(=O)NCc2ccccc2)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5175558	192826	0	None	-72	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	332	6	3	4	1.6	Cc1nnc(CCCN/C(N)=N/C(=O)NCc2ccccc2)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221581	192826	0	None	-72	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	332	6	3	4	1.6	Cc1nnc(CCCN/C(N)=N/C(=O)NCc2ccccc2)s1	10.1021/acs.jmedchem.1c00692
		867637	55187	4	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	291	5	1	4	3.0	C=CCn1c(=N)n(CC(=O)c2ccccc2)c2ccccc21	10.1021/jm2011589
		CHEMBL1617548	55187	4	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	291	5	1	4	3.0	C=CCn1c(=N)n(CC(=O)c2ccccc2)c2ccccc21	10.1021/jm2011589
		164612037	185377	0	None	-204173	20	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1016/j.ejmech.2021.113190
		CHEMBL4860528	185377	0	None	-204173	20	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1016/j.ejmech.2021.113190
		44288874	101095	0	None	-107	7	Human	7.0	pKi	=	7.0	Binding	Selectivity screen against human Histamine H1 receptorSelectivity screen against human Histamine H1 receptor	ChEMBL	528	7	2	4	4.2	CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3F)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1	10.1016/s0960-894x(99)00696-4
		CHEMBL295001	101095	0	None	-107	7	Human	7.0	pKi	=	7.0	Binding	Selectivity screen against human Histamine H1 receptorSelectivity screen against human Histamine H1 receptor	ChEMBL	528	7	2	4	4.2	CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3F)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1	10.1016/s0960-894x(99)00696-4
		168287539	191559	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding affinity to H1 receptor (unknown origin)Binding affinity to H1 receptor (unknown origin)	ChEMBL	392	7	2	4	3.7	CCOc1ccc(F)cc1NC(=O)c1cc(C)ccc1NS(=O)(=O)C1CC1	10.1021/acsmedchemlett.2c00100
		CHEMBL5194692	191559	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding affinity to H1 receptor (unknown origin)Binding affinity to H1 receptor (unknown origin)	ChEMBL	392	7	2	4	3.7	CCOc1ccc(F)cc1NC(=O)c1cc(C)ccc1NS(=O)(=O)C1CC1	10.1021/acsmedchemlett.2c00100
		53326724	57753	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	332	7	0	4	3.8	C[C@H](C1=C(CCN(C)CCC#N)Cc2ccccc21)c1cnccn1	10.1016/j.bmcl.2010.12.053
		CHEMBL1669410	57753	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	332	7	0	4	3.8	C[C@H](C1=C(CCN(C)CCC#N)Cc2ccccc21)c1cnccn1	10.1016/j.bmcl.2010.12.053
		23381046	66754	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsBinding affinity towards human histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	548	10	2	5	4.7	NC(=O)N(O)CCC#Cc1ccc(OCCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1016/j.bmcl.2004.08.060
		CHEMBL185825	66754	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsBinding affinity towards human histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	548	10	2	5	4.7	NC(=O)N(O)CCC#Cc1ccc(OCCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1016/j.bmcl.2004.08.060
		168269382	189920	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	818	21	6	8	3.1	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5169902	189920	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	818	21	6	8	3.1	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		44304438	203168	0	None	-100	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	420	13	0	5	4.1	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)CSCC)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL64235	203168	0	None	-100	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	420	13	0	5	4.1	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)CSCC)CC2)cc1	10.1016/s0960-894x(02)00309-8
		3570228	69033	67	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	213	4	1	2	3.0	NCCc1ccccc1Oc1ccccc1	10.1021/jm2011589
		CHEMBL1923535	69033	67	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	213	4	1	2	3.0	NCCc1ccccc1Oc1ccccc1	10.1021/jm2011589
		141485890	173280	0	None	-	1	Guinea pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysisDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysis	ChEMBL	331	6	0	4	1.7	CCN1CCN(CCCOc2ccc3c(c2)C(=O)N(C)CC3)CC1	10.1016/j.bmcl.2019.04.015
		CHEMBL4525456	173280	0	None	-	1	Guinea pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysisDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysis	ChEMBL	331	6	0	4	1.7	CCN1CCN(CCCOc2ccc3c(c2)C(=O)N(C)CC3)CC1	10.1016/j.bmcl.2019.04.015
		2337	3256	77	None	1	62	Human	8.0	pKi	=	8.0	Binding	Binding affinity to H1 histamine receptor (unknown origin)Binding affinity to H1 histamine receptor (unknown origin)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1016/j.bmcl.2020.127681
		50	3256	77	None	1	62	Human	8.0	pKi	=	8.0	Binding	Binding affinity to H1 histamine receptor (unknown origin)Binding affinity to H1 histamine receptor (unknown origin)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1016/j.bmcl.2020.127681
		5002	3256	77	None	1	62	Human	8.0	pKi	=	8.0	Binding	Binding affinity to H1 histamine receptor (unknown origin)Binding affinity to H1 histamine receptor (unknown origin)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1016/j.bmcl.2020.127681
		CHEMBL716	3256	77	None	1	62	Human	8.0	pKi	=	8.0	Binding	Binding affinity to H1 histamine receptor (unknown origin)Binding affinity to H1 histamine receptor (unknown origin)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1016/j.bmcl.2020.127681
		DB01224	3256	77	None	1	62	Human	8.0	pKi	=	8.0	Binding	Binding affinity to H1 histamine receptor (unknown origin)Binding affinity to H1 histamine receptor (unknown origin)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1016/j.bmcl.2020.127681
		15749427	102059	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	323	4	1	3	3.2	CN(C)C/C=C1\c2ccccc2COc2ccc(CC(=O)O)cc21	10.1021/jm300682j
		CHEMBL302005	102059	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	323	4	1	3	3.2	CN(C)C/C=C1\c2ccccc2COc2ccc(CC(=O)O)cc21	10.1021/jm300682j
		191	403	98	None	-56	29	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		201	403	98	None	-56	29	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		2170	403	98	None	-56	29	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		CHEMBL1113	403	98	None	-56	29	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		DB00543	403	98	None	-56	29	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		11544156	194901	0	None	-123	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation counting	ChEMBL	313	5	0	2	4.7	CN(C)CCc1sc2ccccc2c1Cc1ccc(F)cc1	10.1021/jm900933k
		CHEMBL540982	194901	0	None	-123	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation counting	ChEMBL	313	5	0	2	4.7	CN(C)CCc1sc2ccccc2c1Cc1ccc(F)cc1	10.1021/jm900933k
		15749427	102059	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Inhibition constant against histamine H1 receptorInhibition constant against histamine H1 receptor	ChEMBL	323	4	1	3	3.2	CN(C)C/C=C1\c2ccccc2COc2ccc(CC(=O)O)cc21	10.1021/jm058225d
		CHEMBL302005	102059	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Inhibition constant against histamine H1 receptorInhibition constant against histamine H1 receptor	ChEMBL	323	4	1	3	3.2	CN(C)C/C=C1\c2ccccc2COc2ccc(CC(=O)O)cc21	10.1021/jm058225d
		15749427	102059	0	None	-1	2	Guinea pig	8.0	pKi	=	8.0	Binding	Inhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptorInhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptor	ChEMBL	323	4	1	3	3.2	CN(C)C/C=C1\c2ccccc2COc2ccc(CC(=O)O)cc21	10.1021/jm00055a013
		CHEMBL302005	102059	0	None	-1	2	Guinea pig	8.0	pKi	=	8.0	Binding	Inhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptorInhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptor	ChEMBL	323	4	1	3	3.2	CN(C)C/C=C1\c2ccccc2COc2ccc(CC(=O)O)cc21	10.1021/jm00055a013
		15749427	102059	0	None	-1	2	Guinea pig	8.0	pKi	=	8.0	Binding	The compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMThe compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	323	4	1	3	3.2	CN(C)C/C=C1\c2ccccc2COc2ccc(CC(=O)O)cc21	10.1021/jm00089a020
		CHEMBL302005	102059	0	None	-1	2	Guinea pig	8.0	pKi	=	8.0	Binding	The compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMThe compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	323	4	1	3	3.2	CN(C)C/C=C1\c2ccccc2COc2ccc(CC(=O)O)cc21	10.1021/jm00089a020
		46884668	8289	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	293	5	0	3	3.3	Cc1ccc2c(c1)CC(CCN(C)C)=C2Cc1cnccn1	10.1016/j.bmcl.2010.02.055
		CHEMBL1092600	8289	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	293	5	0	3	3.3	Cc1ccc2c(c1)CC(CCN(C)C)=C2Cc1cnccn1	10.1016/j.bmcl.2010.02.055
		24769156	116217	0	None	-181	4	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	388	7	1	4	3.6	O=C(NCCCCN1CCN(c2ccccc2)CC1)c1ccc2ncccc2c1	10.1021/jm501119j
		CHEMBL3358509	116217	0	None	-181	4	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	388	7	1	4	3.6	O=C(NCCCCN1CCN(c2ccccc2)CC1)c1ccc2ncccc2c1	10.1021/jm501119j
		168269382	189920	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	818	21	6	8	3.1	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5169902	189920	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	818	21	6	8	3.1	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		16006492	97469	7	None	-275	6	Human	6.0	pKi	=	6.0	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	195	0	2	3	2.0	CC1NC(N)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.080
		CHEMBL270177	97469	7	None	-275	6	Human	6.0	pKi	=	6.0	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	195	0	2	3	2.0	CC1NC(N)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.080
		44334037	4446	0	None	-199	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	450	9	1	7	3.7	CC(=O)c1ccc(OCCCN2CC[C@H](NC(=O)c3csc(-c4cccnc4)n3)C2)cc1	10.1016/s0960-894x(02)00685-6
		CHEMBL101634	4446	0	None	-199	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	450	9	1	7	3.7	CC(=O)c1ccc(OCCCN2CC[C@H](NC(=O)c3csc(-c4cccnc4)n3)C2)cc1	10.1016/s0960-894x(02)00685-6
		95339350	162882	1	None	3	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	277	4	0	4	1.9	COC[C@@H](C)N1CCN(c2cccc(F)c2C#N)CC1	10.1021/acs.jmedchem.8b00718
		CHEMBL4173442	162882	1	None	3	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	277	4	0	4	1.9	COC[C@@H](C)N1CCN(c2cccc(F)c2C#N)CC1	10.1021/acs.jmedchem.8b00718
		141485895	175197	0	None	-	1	Guinea pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysisDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysis	ChEMBL	304	5	1	4	1.2	CN1CCc2ccc(OCCCN3CCC(O)C3)cc2C1=O	10.1016/j.bmcl.2019.04.015
		CHEMBL4570965	175197	0	None	-	1	Guinea pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysisDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysis	ChEMBL	304	5	1	4	1.2	CN1CCc2ccc(OCCCN3CCC(O)C3)cc2C1=O	10.1016/j.bmcl.2019.04.015
		112936251	137266	1	None	-1	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	359	5	1	5	3.5	CN1CCN(c2cc(-c3ccccc3)nc(NCc3ccccc3)n2)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL3752085	137266	1	None	-1	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	359	5	1	5	3.5	CN1CCN(c2cc(-c3ccccc3)nc(NCc3ccccc3)n2)CC1	10.1016/j.bmcl.2015.12.035
		44304991	203061	0	None	-891	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	424	12	0	5	3.6	CCCCCC(=O)c1ccc(OCCCN2CCN(S(=O)(=O)C(C)C)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL63631	203061	0	None	-891	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	424	12	0	5	3.6	CCCCCC(=O)c1ccc(OCCCN2CCN(S(=O)(=O)C(C)C)CC2)cc1	10.1016/s0960-894x(02)00309-8
		71525679	89726	0	None	-794	6	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human histamine H1 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H1 receptor expressed in HEK cells	ChEMBL	272	3	2	6	1.0	CCc1cnc2c(N3CC[C@@H](NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376801	89726	0	None	-794	6	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]histamine from human histamine H1 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H1 receptor expressed in HEK cells	ChEMBL	272	3	2	6	1.0	CCc1cnc2c(N3CC[C@@H](NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		57334553	90475	0	None	-3715	13	Guinea pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysisDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysis	ChEMBL	484	7	0	6	6.1	Cc1cc(=O)oc2c(Cl)c(OCCCCN3CCC(c4noc5cc(F)ccc45)CC3)ccc12	10.1021/jm400408r
		CHEMBL2387229	90475	0	None	-3715	13	Guinea pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysisDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysis	ChEMBL	484	7	0	6	6.1	Cc1cc(=O)oc2c(Cl)c(OCCCCN3CCC(c4noc5cc(F)ccc45)CC3)ccc12	10.1021/jm400408r
		44324800	206948	0	None	-371	7	Human	7.0	pKi	=	7.0	Binding	Inhibition of [3H]pyrilamine binding to Histamine H1 receptorInhibition of [3H]pyrilamine binding to Histamine H1 receptor	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CO2	10.1021/jm049619s
		CHEMBL91157	206948	0	None	-371	7	Human	7.0	pKi	=	7.0	Binding	Inhibition of [3H]pyrilamine binding to Histamine H1 receptorInhibition of [3H]pyrilamine binding to Histamine H1 receptor	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CO2	10.1021/jm049619s
		94496003	162865	1	None	-20	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	331	5	1	5	2.8	C[C@H](CNc1cncc(Cl)n1)N1CCN(c2ccccc2)CC1	10.1021/acs.jmedchem.8b00718
		CHEMBL4173176	162865	1	None	-20	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	331	5	1	5	2.8	C[C@H](CNc1cncc(Cl)n1)N1CCN(c2ccccc2)CC1	10.1021/acs.jmedchem.8b00718
		5048	3133	64	None	-109	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	10.1016/j.ejmech.2014.03.014
		8924	3133	64	None	-109	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	10.1016/j.ejmech.2014.03.014
		9948102	3133	64	None	-109	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	10.1016/j.ejmech.2014.03.014
		CHEMBL462605	3133	64	None	-109	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	10.1016/j.ejmech.2014.03.014
		DB11642	3133	64	None	-109	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	10.1016/j.ejmech.2014.03.014
		21533446	70155	0	None	-30	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation countingDisplacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation counting	ChEMBL	379	6	1	3	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCSc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
		CHEMBL1940403	70155	0	None	-30	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation countingDisplacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation counting	ChEMBL	379	6	1	3	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCSc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
		44267115	9903	0	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.	ChEMBL	394	1	0	3	4.5	CC(=O)c1cnc2c(c1)CCc1cc(Cl)ccc1C2=C1CCN(C(C)=O)CC1	10.1016/S0960-894X(00)80290-5
		CHEMBL11435	9903	0	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.	ChEMBL	394	1	0	3	4.5	CC(=O)c1cnc2c(c1)CCc1cc(Cl)ccc1C2=C1CCN(C(C)=O)CC1	10.1016/S0960-894X(00)80290-5
		107782	14468	18	None	1	5	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	472	4	4	6	2.0	C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)(O)O	nan
		67151996	14468	18	None	1	5	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	472	4	4	6	2.0	C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)(O)O	nan
		CHEMBL1201207	14468	18	None	1	5	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	472	4	4	6	2.0	C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)(O)O	nan
		127026019	137460	0	None	6	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	378	2	0	6	1.7	CN1CCN(c2nc3c(c(N4CCN(C)CC4)n2)-c2ccccc2CC3)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL3753705	137460	0	None	6	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	378	2	0	6	1.7	CN1CCN(c2nc3c(c(N4CCN(C)CC4)n2)-c2ccccc2CC3)CC1	10.1016/j.bmcl.2015.12.035
		168276112	190272	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	790	19	6	8	3.2	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5175594	190272	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	790	19	6	8	3.2	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168276112	190272	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	790	19	6	8	3.2	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5175594	190272	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	790	19	6	8	3.2	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		45815848	162304	5	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	330	4	0	5	3.2	CC(C)(C)c1nc(CN2CCN(Cc3ccccn3)CC2)cs1	10.1021/acs.jmedchem.8b00718
		CHEMBL4164366	162304	5	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	330	4	0	5	3.2	CC(C)(C)c1nc(CN2CCN(Cc3ccccn3)CC2)cs1	10.1021/acs.jmedchem.8b00718
		46884600	7719	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	293	5	0	3	3.3	Cc1cncc(CC2=C(CCN(C)C)Cc3ccccc32)n1	10.1016/j.bmcl.2010.02.055
		CHEMBL1088882	7719	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	293	5	0	3	3.3	Cc1cncc(CC2=C(CCN(C)C)Cc3ccccc32)n1	10.1016/j.bmcl.2010.02.055
		11277528	170102	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity for H1 histamine receptor expressed in CHO cellsBinding affinity for H1 histamine receptor expressed in CHO cells	ChEMBL	282	0	1	5	1.6	Cn1ccc2c1C(=O)Cn1ccnc1C2=C1CCNCC1	10.1021/jm049495j
		CHEMBL444353	170102	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity for H1 histamine receptor expressed in CHO cellsBinding affinity for H1 histamine receptor expressed in CHO cells	ChEMBL	282	0	1	5	1.6	Cn1ccc2c1C(=O)Cn1ccnc1C2=C1CCNCC1	10.1021/jm049495j
		15749426	11284	0	None	-	1	Guinea pig	7.9	pKi	=	7.9	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	309	3	1	3	3.3	CN(C)C/C=C1\c2ccccc2COc2ccc(C(=O)O)cc21	10.1021/jm00089a020
		CHEMBL1179173	11284	0	None	-	1	Guinea pig	7.9	pKi	=	7.9	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	309	3	1	3	3.3	CN(C)C/C=C1\c2ccccc2COc2ccc(C(=O)O)cc21	10.1021/jm00089a020
		CHEMBL63424	11284	0	None	-	1	Guinea pig	7.9	pKi	=	7.9	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	309	3	1	3	3.3	CN(C)C/C=C1\c2ccccc2COc2ccc(C(=O)O)cc21	10.1021/jm00089a020
		6603950	203324	9	None	-19	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsDisplacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	344	1	0	3	4.3	CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm100652h
		CHEMBL64875	203324	9	None	-19	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsDisplacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	344	1	0	3	4.3	CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm100652h
		11580426	7944	3	None	117	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	310	5	0	3	4.6	CC(c1ccccn1)c1c(CCN(C)C)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		CHEMBL1090432	7944	3	None	117	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	310	5	0	3	4.6	CC(c1ccccn1)c1c(CCN(C)C)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		10028980	24697	0	None	-	1	Guinea pig	7.9	pKi	=	7.9	Binding	Inhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptorInhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptor	ChEMBL	501	9	1	4	6.4	O=C(O)CCc1ccc2c(c1)C(SCCN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2	10.1021/jm00055a013
		CHEMBL134377	24697	0	None	-	1	Guinea pig	7.9	pKi	=	7.9	Binding	Inhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptorInhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptor	ChEMBL	501	9	1	4	6.4	O=C(O)CCc1ccc2c(c1)C(SCCN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2	10.1021/jm00055a013
		135398737	958	93	None	-2	89	Guinea pig	7.9	pKi	=	7.9	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates after 60 mins by liquid scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates after 60 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2015.09.045
		38	958	93	None	-2	89	Guinea pig	7.9	pKi	=	7.9	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates after 60 mins by liquid scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates after 60 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2015.09.045
		722	958	93	None	-2	89	Guinea pig	7.9	pKi	=	7.9	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates after 60 mins by liquid scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates after 60 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2015.09.045
		CHEMBL42	958	93	None	-2	89	Guinea pig	7.9	pKi	=	7.9	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates after 60 mins by liquid scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates after 60 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2015.09.045
		DB00363	958	93	None	-2	89	Guinea pig	7.9	pKi	=	7.9	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates after 60 mins by liquid scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates after 60 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2015.09.045
		49836410	18735	0	None	3	4	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation countingDisplacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation counting	ChEMBL	393	2	1	2	4.5	O=C(O)C1(F)CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
		CHEMBL1277678	18735	0	None	3	4	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation countingDisplacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation counting	ChEMBL	393	2	1	2	4.5	O=C(O)C1(F)CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
		11437142	202606	2	None	-	1	Guinea pig	7.9	pKi	=	7.9	Binding	Inhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranesInhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	269	6	0	2	3.7	Cc1ccc([C@@H](OCCN(C)C)c2ccccc2)cc1	10.1021/jm00017a019
		CHEMBL612084	202606	2	None	-	1	Guinea pig	7.9	pKi	=	7.9	Binding	Inhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranesInhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes	ChEMBL	269	6	0	2	3.7	Cc1ccc([C@@H](OCCN(C)C)c2ccccc2)cc1	10.1021/jm00017a019
		11097588	202138	2	None	-	1	Guinea pig	7.9	pKi	=	7.9	Binding	Inhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 minInhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 min	ChEMBL	269	6	0	2	3.7	Cc1ccc([C@H](OCCN(C)C)c2ccccc2)cc1	10.1021/jm00017a019
		CHEMBL609131	202138	2	None	-	1	Guinea pig	7.9	pKi	=	7.9	Binding	Inhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 minInhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 min	ChEMBL	269	6	0	2	3.7	Cc1ccc([C@H](OCCN(C)C)c2ccccc2)cc1	10.1021/jm00017a019
		16202149	80633	1	None	3	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	556	10	1	4	6.8	CC1(C)CCCN(CCCOc2ccc(C3CCN(C(=O)c4ccc(CCC(=O)O)c5ccccc45)CC3)cc2)C1	10.1021/jm100064d
		CHEMBL2151156	80633	1	None	3	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	556	10	1	4	6.8	CC1(C)CCCN(CCCOc2ccc(C3CCN(C(=O)c4ccc(CCC(=O)O)c5ccccc45)CC3)cc2)C1	10.1021/jm100064d
		71450777	84203	0	None	63	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	404	7	0	4	5.2	N#Cc1cccc(OCCCN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1	10.1016/j.bmcl.2012.09.113
		CHEMBL2208420	84203	0	None	63	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	404	7	0	4	5.2	N#Cc1cccc(OCCCN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1	10.1016/j.bmcl.2012.09.113
		59295926	84218	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	474	7	2	6	3.6	O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1cnnc2ccccc12	10.1016/j.bmcl.2012.09.113
		CHEMBL2208435	84218	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	474	7	2	6	3.6	O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1cnnc2ccccc12	10.1016/j.bmcl.2012.09.113
		59295984	84011	0	None	-3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	487	7	3	5	3.3	Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3cc(F)ccc23)CC1	10.1016/j.bmcl.2012.09.112
		CHEMBL2207279	84011	0	None	-3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	487	7	3	5	3.3	Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3cc(F)ccc23)CC1	10.1016/j.bmcl.2012.09.112
		59296033	84018	0	None	-15	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	596	9	3	7	2.7	CN(C)S(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1	10.1016/j.bmcl.2012.09.112
		CHEMBL2207286	84018	0	None	-15	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	596	9	3	7	2.7	CN(C)S(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1	10.1016/j.bmcl.2012.09.112
		71459762	84091	0	None	-7	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	452	8	3	5	3.2	O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]nc1C1CC1	10.1016/j.bmcl.2012.09.112
		CHEMBL2207661	84091	0	None	-7	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	452	8	3	5	3.2	O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]nc1C1CC1	10.1016/j.bmcl.2012.09.112
		7077	66959	27	None	3	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	255	6	0	2	3.2	CN(C)CCOc1ccccc1Cc1ccccc1	10.1021/acs.jmedchem.6b00981
		CHEMBL186720	66959	27	None	3	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	255	6	0	2	3.2	CN(C)CCOc1ccccc1Cc1ccccc1	10.1021/acs.jmedchem.6b00981
		CHEMBL3925724	66959	27	None	3	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	255	6	0	2	3.2	CN(C)CCOc1ccccc1Cc1ccccc1	10.1021/acs.jmedchem.6b00981
		3359700	143095	2	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	309	7	0	2	4.5	c1ccc(Cc2ccccc2OCCCN2CCCCC2)cc1	10.1021/acs.jmedchem.6b00981
		CHEMBL3895427	143095	2	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	309	7	0	2	4.5	c1ccc(Cc2ccccc2OCCCN2CCCCC2)cc1	10.1021/acs.jmedchem.6b00981
		11742610	207029	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	415	2	0	3	5.6	Cc1ccncc1CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/acs.jmedchem.9b00447
		CHEMBL91565	207029	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	415	2	0	3	5.6	Cc1ccncc1CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/acs.jmedchem.9b00447
		144950987	179970	0	None	95	6	Human	6.9	pKi	=	6.9	Binding	Binding affinity to H1 receptor (unknown origin)Binding affinity to H1 receptor (unknown origin)	ChEMBL	292	3	0	2	3.4	CN(C)CCN1C(=O)c2ccccc2/C=C\c2ccccc21	10.1016/j.bmcl.2020.127493
		CHEMBL4746800	179970	0	None	95	6	Human	6.9	pKi	=	6.9	Binding	Binding affinity to H1 receptor (unknown origin)Binding affinity to H1 receptor (unknown origin)	ChEMBL	292	3	0	2	3.4	CN(C)CCN1C(=O)c2ccccc2/C=C\c2ccccc21	10.1016/j.bmcl.2020.127493
		46884154	8325	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	340	6	0	4	4.6	COc1ccc(C(C)c2c(CCN(C)C)sc3ccccc23)cn1	10.1016/j.bmcl.2010.01.134
		CHEMBL1092812	8325	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	340	6	0	4	4.6	COc1ccc(C(C)c2c(CCN(C)C)sc3ccccc23)cn1	10.1016/j.bmcl.2010.01.134
		14885639	118569	0	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	351	1	0	2	5.4	CC(=O)C1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/jm00105a069
		CHEMBL341584	118569	0	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	351	1	0	2	5.4	CC(=O)C1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/jm00105a069
		44352308	117487	0	None	-1479	12	Rat	4.9	pKi	=	4.9	Binding	Binding affinity towards rat histamine H1 receptor was determined using [3H]pyrilamine as radioligandBinding affinity towards rat histamine H1 receptor was determined using [3H]pyrilamine as radioligand	ChEMBL	339	5	2	2	4.0	Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C	10.1021/jm0155190
		CHEMBL339980	117487	0	None	-1479	12	Rat	4.9	pKi	=	4.9	Binding	Binding affinity towards rat histamine H1 receptor was determined using [3H]pyrilamine as radioligandBinding affinity towards rat histamine H1 receptor was determined using [3H]pyrilamine as radioligand	ChEMBL	339	5	2	2	4.0	Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C	10.1021/jm0155190
		44304382	203302	0	None	-125	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	403	11	1	4	4.0	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)NC(C)C)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL64773	203302	0	None	-125	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	403	11	1	4	4.0	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)NC(C)C)CC2)cc1	10.1016/s0960-894x(02)00309-8
		164627774	186565	0	None	-2	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	344	3	4	4	1.4	N/C(=N\C(=O)NCc1ccccc1)NC1CCc2nc(N)sc2C1	10.1016/j.ejmech.2021.113190
		CHEMBL4878215	186565	0	None	-2	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	344	3	4	4	1.4	N/C(=N\C(=O)NCc1ccccc1)NC1CCc2nc(N)sc2C1	10.1016/j.ejmech.2021.113190
		44304030	200962	0	None	-91	3	Human	4.9	pKi	=	4.9	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	511	11	1	5	4.4	N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		CHEMBL60189	200962	0	None	-91	3	Human	4.9	pKi	=	4.9	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	511	11	1	5	4.4	N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		118709750	113540	0	None	-109	9	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation countingDisplacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1cccc(F)c1	10.1016/j.bmcl.2014.07.018
		CHEMBL3321791	113540	0	None	-109	9	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation countingDisplacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1cccc(F)c1	10.1016/j.bmcl.2014.07.018
		155564280	175423	0	None	-	1	Guinea pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysisDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysis	ChEMBL	290	4	0	4	1.0	CN1CCc2ccc(OCCN3CCOCC3)cc2C1=O	10.1016/j.bmcl.2019.04.015
		CHEMBL4576048	175423	0	None	-	1	Guinea pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysisDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysis	ChEMBL	290	4	0	4	1.0	CN1CCc2ccc(OCCN3CCOCC3)cc2C1=O	10.1016/j.bmcl.2019.04.015
		45485525	197799	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation counting	ChEMBL	337	7	1	2	4.8	Cc1ccc(CCCCN2CCC(C(O)c3ccccc3)CC2)cc1	10.1016/j.bmcl.2009.07.047
		CHEMBL572034	197799	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation counting	ChEMBL	337	7	1	2	4.8	Cc1ccc(CCCCN2CCC(C(O)c3ccccc3)CC2)cc1	10.1016/j.bmcl.2009.07.047
		46884239	8436	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	299	5	0	4	3.8	CC(c1c(CCN(C)C)sc2ccccc12)n1ccnc1	10.1016/j.bmcl.2010.01.134
		CHEMBL1093607	8436	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	299	5	0	4	3.8	CC(c1c(CCN(C)C)sc2ccccc12)n1ccnc1	10.1016/j.bmcl.2010.01.134
		57345619	70464	0	None	-13	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-Pyrilamine from human histamine H1 receptor by liquid scintillation counterDisplacement of [3H]-Pyrilamine from human histamine H1 receptor by liquid scintillation counter	ChEMBL	360	6	0	2	5.0	Fc1ccc(CCCCN2CCCN(c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmc.2012.01.022
		CHEMBL1946253	70464	0	None	-13	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-Pyrilamine from human histamine H1 receptor by liquid scintillation counterDisplacement of [3H]-Pyrilamine from human histamine H1 receptor by liquid scintillation counter	ChEMBL	360	6	0	2	5.0	Fc1ccc(CCCCN2CCCN(c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmc.2012.01.022
		28390601	162972	0	None	-2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	377	4	0	5	3.9	Cc1oc(-c2ccco2)nc1CN1CCN([C@@H]2CCc3ccccc3C2)CC1	10.1021/acs.jmedchem.8b00718
		CHEMBL4175018	162972	0	None	-2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	377	4	0	5	3.9	Cc1oc(-c2ccco2)nc1CN1CCN([C@@H]2CCc3ccccc3C2)CC1	10.1021/acs.jmedchem.8b00718
		69347707	81305	1	None	5	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	476	7	1	4	5.4	O=C(O)c1ccc(CN2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158833	81305	1	None	5	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	476	7	1	4	5.4	O=C(O)c1ccc(CN2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1	10.1016/j.bmcl.2012.08.103
		71072057	81312	0	None	-5	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	508	8	1	4	5.4	O=C(O)[C@H](Cc1cccc(F)c1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158840	81312	0	None	-5	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	508	8	1	4	5.4	O=C(O)[C@H](Cc1cccc(F)c1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		24839550	137315	14	None	-2	15	Human	6.9	pKi	=	6.9	Binding	Binding affinity to histamine H1 receptor (unknown origin) by competition binding assayBinding affinity to histamine H1 receptor (unknown origin) by competition binding assay	ChEMBL	240	7	1	1	3.4	C=CCN(CC=C)CCc1c[nH]c2ccccc12	10.1016/j.bmcl.2015.12.053
		CHEMBL3752576	137315	14	None	-2	15	Human	6.9	pKi	=	6.9	Binding	Binding affinity to histamine H1 receptor (unknown origin) by competition binding assayBinding affinity to histamine H1 receptor (unknown origin) by competition binding assay	ChEMBL	240	7	1	1	3.4	C=CCN(CC=C)CCc1c[nH]c2ccccc12	10.1016/j.bmcl.2015.12.053
		59296094	84099	0	None	-31	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	480	7	3	6	2.7	N#Cc1ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccccc34)CC2)cc1Cl	10.1016/j.bmcl.2012.09.112
		CHEMBL2207669	84099	0	None	-31	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	480	7	3	6	2.7	N#Cc1ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccccc34)CC2)cc1Cl	10.1016/j.bmcl.2012.09.112
		9954003	71700	24	None	-251	9	Guinea pig	6.9	pKi	=	6.9	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	422	5	2	4	3.8	C[C@H]1Oc2c(cccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)NC1=O	10.1021/jm070516u
		CHEMBL196514	71700	24	None	-251	9	Guinea pig	6.9	pKi	=	6.9	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	422	5	2	4	3.8	C[C@H]1Oc2c(cccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)NC1=O	10.1021/jm070516u
		71462389	82243	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	476	5	1	4	4.8	O=C(O)c1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1	10.1016/j.bmcl.2012.08.124
		CHEMBL2171024	82243	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	476	5	1	4	4.8	O=C(O)c1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1	10.1016/j.bmcl.2012.08.124
		17963141	82268	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	491	5	1	5	4.1	Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)cc4)CC3)CC2)cc1	10.1016/j.bmcl.2012.08.124
		CHEMBL2171049	82268	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	491	5	1	5	4.1	Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)cc4)CC3)CC2)cc1	10.1016/j.bmcl.2012.08.124
		168296182	192227	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	808	21	7	9	1.8	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5204985	192227	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	808	21	7	9	1.8	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		9971374	104126	0	None	-316	2	Human	5.9	pKi	=	5.9	Binding	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced effect by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced effect by FLIPR assay	ChEMBL	288	5	1	3	2.6	c1cc2c(cc1OCCCN1CCCCC1)CCNCC2	10.1016/j.bmcl.2013.09.089
		CHEMBL3094130	104126	0	None	-316	2	Human	5.9	pKi	=	5.9	Binding	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced effect by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced effect by FLIPR assay	ChEMBL	288	5	1	3	2.6	c1cc2c(cc1OCCCN1CCCCC1)CCNCC2	10.1016/j.bmcl.2013.09.089
		50898777	56440	0	None	-11748	8	Human	5.9	pKi	=	5.9	Binding	Binding affinity to Histamine receptor H1Binding affinity to Histamine receptor H1	ChEMBL	441	9	1	6	3.6	COC(=O)CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1	10.1016/j.bmc.2010.10.011
		CHEMBL1632158	56440	0	None	-11748	8	Human	5.9	pKi	=	5.9	Binding	Binding affinity to Histamine receptor H1Binding affinity to Histamine receptor H1	ChEMBL	441	9	1	6	3.6	COC(=O)CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1	10.1016/j.bmc.2010.10.011
		71461541	84220	0	None	-15	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	513	9	3	6	2.7	CS(=O)(=O)c1ccccc1C(=O)NCC(O)CNC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1	10.1016/j.bmcl.2012.09.113
		CHEMBL2208437	84220	0	None	-15	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	513	9	3	6	2.7	CS(=O)(=O)c1ccccc1C(=O)NCC(O)CNC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1	10.1016/j.bmcl.2012.09.113
		50878551	90745	61	None	-21	18	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
		CHEMBL2391541	90745	61	None	-21	18	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
		10662264	56494	0	None	-812	2	Guinea pig	4.9	pKi	=	4.9	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	304	7	2	5	2.2	O=C(NCc1ccc([N+](=O)[O-])cc1)OCCCc1c[nH]cn1	10.1021/jm9507688
		CHEMBL16338	56494	0	None	-812	2	Guinea pig	4.9	pKi	=	4.9	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	304	7	2	5	2.2	O=C(NCc1ccc([N+](=O)[O-])cc1)OCCCc1c[nH]cn1	10.1021/jm9507688
		10660952	98123	0	None	-190	2	Guinea pig	4.9	pKi	=	4.9	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	287	7	1	3	3.0	CCN(Cc1ccccc1)C(=O)OCCCc1c[nH]cn1	10.1021/jm9507688
		CHEMBL273549	98123	0	None	-190	2	Guinea pig	4.9	pKi	=	4.9	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	287	7	1	3	3.0	CCN(Cc1ccccc1)C(=O)OCCCc1c[nH]cn1	10.1021/jm9507688
		10732219	98944	0	None	-602	2	Guinea pig	4.9	pKi	=	4.9	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	290	6	2	5	2.5	O=C(Nc1cccc([N+](=O)[O-])c1)OCCCc1c[nH]cn1	10.1021/jm9507688
		CHEMBL279617	98944	0	None	-602	2	Guinea pig	4.9	pKi	=	4.9	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	290	6	2	5	2.5	O=C(Nc1cccc([N+](=O)[O-])c1)OCCCc1c[nH]cn1	10.1021/jm9507688
		1204	1932	119	None	-46	24	Guinea pig	4.9	pKi	=	4.9	Binding	Binding affinity against H1 receptor of guinea pig by the displacement of [3H]mepyramine, bound to membranes of CHO cellsBinding affinity against H1 receptor of guinea pig by the displacement of [3H]mepyramine, bound to membranes of CHO cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm00002a008
		1247	1932	119	None	-46	24	Guinea pig	4.9	pKi	=	4.9	Binding	Binding affinity against H1 receptor of guinea pig by the displacement of [3H]mepyramine, bound to membranes of CHO cellsBinding affinity against H1 receptor of guinea pig by the displacement of [3H]mepyramine, bound to membranes of CHO cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm00002a008
		1375	1932	119	None	-46	24	Guinea pig	4.9	pKi	=	4.9	Binding	Binding affinity against H1 receptor of guinea pig by the displacement of [3H]mepyramine, bound to membranes of CHO cellsBinding affinity against H1 receptor of guinea pig by the displacement of [3H]mepyramine, bound to membranes of CHO cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm00002a008
		774	1932	119	None	-46	24	Guinea pig	4.9	pKi	=	4.9	Binding	Binding affinity against H1 receptor of guinea pig by the displacement of [3H]mepyramine, bound to membranes of CHO cellsBinding affinity against H1 receptor of guinea pig by the displacement of [3H]mepyramine, bound to membranes of CHO cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm00002a008
		CHEMBL90	1932	119	None	-46	24	Guinea pig	4.9	pKi	=	4.9	Binding	Binding affinity against H1 receptor of guinea pig by the displacement of [3H]mepyramine, bound to membranes of CHO cellsBinding affinity against H1 receptor of guinea pig by the displacement of [3H]mepyramine, bound to membranes of CHO cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm00002a008
		DB05381	1932	119	None	-46	24	Guinea pig	4.9	pKi	=	4.9	Binding	Binding affinity against H1 receptor of guinea pig by the displacement of [3H]mepyramine, bound to membranes of CHO cellsBinding affinity against H1 receptor of guinea pig by the displacement of [3H]mepyramine, bound to membranes of CHO cells	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/jm00002a008
		44304560	102763	0	None	-9549	3	Human	4.9	pKi	=	4.9	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	371	8	1	5	1.6	O=C(c1ccc(OCCCN2CCN(C(=O)[C@H]3CCN3)CC2)cc1)C1CC1	10.1016/s0960-894x(02)00310-4
		CHEMBL305144	102763	0	None	-9549	3	Human	4.9	pKi	=	4.9	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	371	8	1	5	1.6	O=C(c1ccc(OCCCN2CCN(C(=O)[C@H]3CCN3)CC2)cc1)C1CC1	10.1016/s0960-894x(02)00310-4
		10422468	204158	0	None	-630	3	Guinea pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]mepyramine bound to membranes of CHO cells expressing guinea pig H1 receptorsDisplacement of [3H]mepyramine bound to membranes of CHO cells expressing guinea pig H1 receptors	ChEMBL	254	7	3	2	2.4	CC(C)/N=C(\S)NCCCCCc1c[nH]cn1	10.1021/jm00012a025
		CHEMBL70603	204158	0	None	-630	3	Guinea pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]mepyramine bound to membranes of CHO cells expressing guinea pig H1 receptorsDisplacement of [3H]mepyramine bound to membranes of CHO cells expressing guinea pig H1 receptors	ChEMBL	254	7	3	2	2.4	CC(C)/N=C(\S)NCCCCCc1c[nH]cn1	10.1021/jm00012a025
		1204	1932	119	None	-501	24	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor N7.45S mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor N7.45S mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1038/nchembio714
		1247	1932	119	None	-501	24	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor N7.45S mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor N7.45S mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1038/nchembio714
		1375	1932	119	None	-501	24	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor N7.45S mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor N7.45S mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1038/nchembio714
		774	1932	119	None	-501	24	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor N7.45S mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor N7.45S mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1038/nchembio714
		CHEMBL90	1932	119	None	-501	24	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor N7.45S mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor N7.45S mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1038/nchembio714
		DB05381	1932	119	None	-501	24	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor N7.45S mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor N7.45S mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1038/nchembio714
		164620678	186019	0	None	-199	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	374	7	4	4	2.7	CCC(NC(=O)/N=C(\N)NCCCc1sc(N)nc1C)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4870510	186019	0	None	-199	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	374	7	4	4	2.7	CCC(NC(=O)/N=C(\N)NCCCc1sc(N)nc1C)c1ccccc1	10.1016/j.ejmech.2021.113190
		168296182	192227	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	808	21	7	9	1.8	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5204985	192227	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	808	21	7	9	1.8	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		155567030	176417	0	None	-37	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta scintillation counter methodDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta scintillation counter method	ChEMBL	337	8	0	2	5.8	c1ccc(-c2ccc(OCCCCCN3CCCCCC3)cc2)cc1	10.1016/j.bmc.2017.07.058
		CHEMBL4586133	176417	0	None	-37	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta scintillation counter methodDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta scintillation counter method	ChEMBL	337	8	0	2	5.8	c1ccc(-c2ccc(OCCCCCN3CCCCCC3)cc2)cc1	10.1016/j.bmc.2017.07.058
		CHEMBL4596108	176417	0	None	-37	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta scintillation counter methodDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta scintillation counter method	ChEMBL	337	8	0	2	5.8	c1ccc(-c2ccc(OCCCCCN3CCCCCC3)cc2)cc1	10.1016/j.bmc.2017.07.058
		18337331	116091	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting method	ChEMBL	410	2	0	3	5.5	CC(C)COC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/jm501086v
		CHEMBL3357035	116091	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting method	ChEMBL	410	2	0	3	5.5	CC(C)COC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/jm501086v
		57403525	70154	0	None	-85	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation countingDisplacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation counting	ChEMBL	361	6	1	2	4.8	OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
		CHEMBL1940402	70154	0	None	-85	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation countingDisplacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation counting	ChEMBL	361	6	1	2	4.8	OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
		168295543	193041	0	None	-1	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	380	4	4	4	3.3	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCc2ccccc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5209021	193041	0	None	-1	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	380	4	4	4	3.3	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCc2ccccc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222929	193041	0	None	-1	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	380	4	4	4	3.3	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCc2ccccc2)cc1	10.1021/acs.jmedchem.1c00692
		57390695	70467	0	None	3	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-Pyrilamine from human histamine H1 receptor by liquid scintillation counterDisplacement of [3H]-Pyrilamine from human histamine H1 receptor by liquid scintillation counter	ChEMBL	427	7	0	5	5.5	O=C(CCCCN1CCCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1	10.1016/j.bmc.2012.01.022
		CHEMBL1946257	70467	0	None	3	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-Pyrilamine from human histamine H1 receptor by liquid scintillation counterDisplacement of [3H]-Pyrilamine from human histamine H1 receptor by liquid scintillation counter	ChEMBL	427	7	0	5	5.5	O=C(CCCCN1CCCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1	10.1016/j.bmc.2012.01.022
		127035062	136451	0	None	-44	19	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]Pyrilamine from human H1 Histamine receptors stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]Pyrilamine from human H1 Histamine receptors stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
		CHEMBL3735756	136451	0	None	-44	19	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]Pyrilamine from human H1 Histamine receptors stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]Pyrilamine from human H1 Histamine receptors stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
		53322959	57750	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	325	7	0	3	3.9	C[C@H](C1=C(CCN(C)CCF)Cc2ccccc21)c1cnccn1	10.1016/j.bmcl.2010.12.053
		CHEMBL1669408	57750	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	325	7	0	3	3.9	C[C@H](C1=C(CCN(C)CCF)Cc2ccccc21)c1cnccn1	10.1016/j.bmcl.2010.12.053
		11493620	8268	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	328	5	0	3	4.7	C[C@@H](c1ccc(F)cn1)c1c(CCN(C)C)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		CHEMBL1092495	8268	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	328	5	0	3	4.7	C[C@@H](c1ccc(F)cn1)c1c(CCN(C)C)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		76332519	105477	0	None	-1	4	Guinea pig	7.9	pKi	=	7.9	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenate after 60 mins by liquid scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenate after 60 mins by liquid scintillation counting	ChEMBL	510	7	0	6	6.3	O=c1oc2c(Cl)c(OCCCCN3CCC(c4noc5cc(F)ccc45)CC3)ccc2c2c1CCC2	10.1016/j.ejmech.2014.01.012
		CHEMBL3120697	105477	0	None	-1	4	Guinea pig	7.9	pKi	=	7.9	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenate after 60 mins by liquid scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenate after 60 mins by liquid scintillation counting	ChEMBL	510	7	0	6	6.3	O=c1oc2c(Cl)c(OCCCCN3CCC(c4noc5cc(F)ccc45)CC3)ccc2c2c1CCC2	10.1016/j.ejmech.2014.01.012
		53324167	57767	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	370	7	0	4	4.5	C[C@H](C1=C(CCN(C)Cc2ccccn2)Cc2ccccc21)c1cnccn1	10.1016/j.bmcl.2010.12.053
		CHEMBL1669424	57767	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	370	7	0	4	4.5	C[C@H](C1=C(CCN(C)Cc2ccccn2)Cc2ccccc21)c1cnccn1	10.1016/j.bmcl.2010.12.053
		44334036	167792	0	None	-323	3	Human	4.9	pKi	=	4.9	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	391	8	1	5	3.0	CC(=O)c1ccc(OCCCN2CC[C@H](NC(=O)c3ccc(C#N)cc3)C2)cc1	10.1016/s0960-894x(02)00685-6
		CHEMBL430502	167792	0	None	-323	3	Human	4.9	pKi	=	4.9	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	391	8	1	5	3.0	CC(=O)c1ccc(OCCCN2CC[C@H](NC(=O)c3ccc(C#N)cc3)C2)cc1	10.1016/s0960-894x(02)00685-6
		168271050	189932	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	774	19	5	7	3.5	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5170060	189932	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	774	19	5	7	3.5	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168271050	189932	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	774	19	5	7	3.5	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5170060	189932	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	774	19	5	7	3.5	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL4576555	214017	5	None	-1	19	Human	5.9	pKi	=	5.9	Binding	GPCRScan assay: inhibition of H1GPCRScan assay: inhibition of H1	ChEMBL		None	None	None		CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5cc(C(C)(C)C)cc(C(C)(C)C)c5)ccc4n3)cc2)CC1	10.6019/CHEMBL4507307
		168268827	192779	0	None	-4	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	450	8	4	4	4.8	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5179906	192779	0	None	-4	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	450	8	4	4	4.8	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221314	192779	0	None	-4	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	450	8	4	4	4.8	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)c1	10.1021/acs.jmedchem.1c00692
		72138721	162229	3	None	-3	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	349	6	1	5	2.9	Fc1ccccc1N1CCN(CCCNc2cncc(Cl)n2)CC1	10.1021/acs.jmedchem.8b00718
		CHEMBL4163265	162229	3	None	-3	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	349	6	1	5	2.9	Fc1ccccc1N1CCN(CCCNc2cncc(Cl)n2)CC1	10.1021/acs.jmedchem.8b00718
		168268853	192785	0	None	-19	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	389	8	4	5	1.9	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5180504	192785	0	None	-19	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	389	8	4	5	1.9	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221353	192785	0	None	-19	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	389	8	4	5	1.9	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
		164624107	185722	0	None	-29	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	402	9	4	4	2.8	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)CCc1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4865765	185722	0	None	-29	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	402	9	4	4	2.8	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)CCc1ccccc1	10.1016/j.ejmech.2021.113190
		44304990	203062	0	None	-363	3	Human	4.9	pKi	=	4.9	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	483	12	0	6	4.1	CCCCCC(=O)c1ccc(OCCCN2CCN(S(=O)(=O)c3ccc(C#N)cc3)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL63632	203062	0	None	-363	3	Human	4.9	pKi	=	4.9	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	483	12	0	6	4.1	CCCCCC(=O)c1ccc(OCCCN2CCN(S(=O)(=O)c3ccc(C#N)cc3)CC2)cc1	10.1016/s0960-894x(02)00309-8
		44304066	202765	0	None	-309	3	Human	4.9	pKi	=	4.9	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	449	11	1	5	3.0	CN[C@H](Cc1ccccc1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		CHEMBL62050	202765	0	None	-309	3	Human	4.9	pKi	=	4.9	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	449	11	1	5	3.0	CN[C@H](Cc1ccccc1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		73347825	92540	0	None	1	3	Human	5.9	pKi	=	5.9	Binding	Inhibition of histamine H1 receptor (unknown origin) by PDSP assayInhibition of histamine H1 receptor (unknown origin) by PDSP assay	ChEMBL	311	5	1	3	2.9	COc1ccc(CN[C@H]2C3C4CC5C6C4CC3C6C52)cc1OC	10.1016/j.bmc.2013.07.045
		CHEMBL2432046	92540	0	None	1	3	Human	5.9	pKi	=	5.9	Binding	Inhibition of histamine H1 receptor (unknown origin) by PDSP assayInhibition of histamine H1 receptor (unknown origin) by PDSP assay	ChEMBL	311	5	1	3	2.9	COc1ccc(CN[C@H]2C3C4CC5C6C4CC3C6C52)cc1OC	10.1016/j.bmc.2013.07.045
		18715381	97351	0	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.	ChEMBL	386	0	0	2	4.9	CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3ccc(Cl)nc32)CC1	10.1016/S0960-894X(00)80290-5
		CHEMBL269460	97351	0	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.	ChEMBL	386	0	0	2	4.9	CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3ccc(Cl)nc32)CC1	10.1016/S0960-894X(00)80290-5
		CHEMBL4520788	213975	10	None	-63	25	Human	5.9	pKi	=	5.9	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a HRH1Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a HRH1	ChEMBL		None	None	None		CNCc1ccccc1-c1csc([C@H](C)Nc2nc(C)nc3cc(OC)c(OC)cc23)c1	10.6019/CHEMBL5212743
		44373221	54388	0	None	3	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cellsDisplacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cells	ChEMBL	223	2	1	1	3.1	NCCC1c2ccccc2Cc2ccccc21	10.1016/j.bmc.2009.08.016
		CHEMBL160893	54388	0	None	3	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cellsDisplacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cells	ChEMBL	223	2	1	1	3.1	NCCC1c2ccccc2Cc2ccccc21	10.1016/j.bmc.2009.08.016
		46882180	5841	0	None	-5	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	482	7	2	7	3.7	CCOc1cc(CN2CCC(Nc3nc4cc(Cl)c(S(N)(=O)=O)cc4o3)CC2)ccc1F	10.1016/j.bmcl.2009.09.024
		CHEMBL1079180	5841	0	None	-5	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	482	7	2	7	3.7	CCOc1cc(CN2CCC(Nc3nc4cc(Cl)c(S(N)(=O)=O)cc4o3)CC2)ccc1F	10.1016/j.bmcl.2009.09.024
		9923147	5049	0	None	-2238	4	Human	4.9	pKi	=	4.9	Binding	Binding affinity at human cortical Histamine 1 receptorBinding affinity at human cortical Histamine 1 receptor	ChEMBL	321	6	1	4	3.0	N#Cc1ccc(-c2ccc(OCCCN3CC[C@@H](N)C3)cc2)cc1	10.1016/s0960-894x(02)00648-0
		CHEMBL105267	5049	0	None	-2238	4	Human	4.9	pKi	=	4.9	Binding	Binding affinity at human cortical Histamine 1 receptorBinding affinity at human cortical Histamine 1 receptor	ChEMBL	321	6	1	4	3.0	N#Cc1ccc(-c2ccc(OCCCN3CC[C@@H](N)C3)cc2)cc1	10.1016/s0960-894x(02)00648-0
		44326321	207796	0	None	2	3	Human	7.9	pKi	=	7.9	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	295	2	0	3	4.0	CN(C)CC1C[C@@H]2c3ccccc3Oc3ccccc3[C@H]2O1	10.1016/j.bmcl.2004.03.069
		CHEMBL96158	207796	0	None	2	3	Human	7.9	pKi	=	7.9	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	295	2	0	3	4.0	CN(C)CC1C[C@@H]2c3ccccc3Oc3ccccc3[C@H]2O1	10.1016/j.bmcl.2004.03.069
		2389	3331	118	None	-46	67	Human	7.9	pKi	=	7.9	Binding	Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		5073	3331	118	None	-46	67	Human	7.9	pKi	=	7.9	Binding	Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		96	3331	118	None	-46	67	Human	7.9	pKi	=	7.9	Binding	Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		CHEMBL85	3331	118	None	-46	67	Human	7.9	pKi	=	7.9	Binding	Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		DB00734	3331	118	None	-46	67	Human	7.9	pKi	=	7.9	Binding	Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		10382839	116552	0	None	-	1	Guinea pig	7.9	pKi	=	7.9	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	343	5	1	4	3.7	CN(C)CCSC1c2ccccc2COc2ccc(C(=O)O)cc21	10.1021/jm00089a020
		CHEMBL336317	116552	0	None	-	1	Guinea pig	7.9	pKi	=	7.9	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	343	5	1	4	3.7	CN(C)CCSC1c2ccccc2COc2ccc(C(=O)O)cc21	10.1021/jm00089a020
		CHEMBL538750	116552	0	None	-	1	Guinea pig	7.9	pKi	=	7.9	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	343	5	1	4	3.7	CN(C)CCSC1c2ccccc2COc2ccc(C(=O)O)cc21	10.1021/jm00089a020
		1222	881	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsBinding affinity towards human histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1016/j.bmcl.2004.08.060
		2678	881	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsBinding affinity towards human histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1016/j.bmcl.2004.08.060
		581	881	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsBinding affinity towards human histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1016/j.bmcl.2004.08.060
		CHEMBL1000	881	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsBinding affinity towards human histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1016/j.bmcl.2004.08.060
		DB00341	881	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsBinding affinity towards human histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1016/j.bmcl.2004.08.060
		12992627	67247	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsBinding affinity towards human histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	570	7	2	5	5.7	NC(=O)N(O)CCC#Cc1ccc(OCCCN2CCC(=C3c4ccc(Cl)cc4CCc4cccnc43)CC2)cc1	10.1016/j.bmcl.2004.08.060
		CHEMBL188021	67247	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsBinding affinity towards human histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	570	7	2	5	5.7	NC(=O)N(O)CCC#Cc1ccc(OCCCN2CCC(=C3c4ccc(Cl)cc4CCc4cccnc43)CC2)cc1	10.1016/j.bmcl.2004.08.060
		135398737	958	93	None	-4	89	Rat	7.9	pKi	=	7.9	Binding	Half-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenateHalf-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm010982y
		38	958	93	None	-4	89	Rat	7.9	pKi	=	7.9	Binding	Half-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenateHalf-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm010982y
		722	958	93	None	-4	89	Rat	7.9	pKi	=	7.9	Binding	Half-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenateHalf-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm010982y
		CHEMBL42	958	93	None	-4	89	Rat	7.9	pKi	=	7.9	Binding	Half-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenateHalf-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm010982y
		DB00363	958	93	None	-4	89	Rat	7.9	pKi	=	7.9	Binding	Half-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenateHalf-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm010982y
		1222	881	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cellsIn vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1016/j.bmcl.2004.02.005
		2678	881	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cellsIn vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1016/j.bmcl.2004.02.005
		581	881	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cellsIn vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1016/j.bmcl.2004.02.005
		CHEMBL1000	881	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cellsIn vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1016/j.bmcl.2004.02.005
		DB00341	881	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cellsIn vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1016/j.bmcl.2004.02.005
		1222	881	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Inhibition constant against histamine H1 receptorInhibition constant against histamine H1 receptor	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1021/jm058225d
		2678	881	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Inhibition constant against histamine H1 receptorInhibition constant against histamine H1 receptor	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1021/jm058225d
		581	881	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Inhibition constant against histamine H1 receptorInhibition constant against histamine H1 receptor	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1021/jm058225d
		CHEMBL1000	881	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Inhibition constant against histamine H1 receptorInhibition constant against histamine H1 receptor	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1021/jm058225d
		DB00341	881	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Inhibition constant against histamine H1 receptorInhibition constant against histamine H1 receptor	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1021/jm058225d
		44401042	124829	0	None	-3	9	Human	7.9	pKi	=	7.9	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	329	2	0	3	4.6	CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL364270	124829	0	None	-3	9	Human	7.9	pKi	=	7.9	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	329	2	0	3	4.6	CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1	10.1021/jm049632c
		10344845	24883	0	None	-	1	Guinea pig	7.9	pKi	=	7.9	Binding	Inhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptorInhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptor	ChEMBL	474	7	1	5	4.9	O=C(O)c1ccc2c(c1)C(SCCN1CCN(Cc3ccccc3)CC1)c1ccccc1CO2	10.1021/jm00055a013
		CHEMBL134543	24883	0	None	-	1	Guinea pig	7.9	pKi	=	7.9	Binding	Inhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptorInhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptor	ChEMBL	474	7	1	5	4.9	O=C(O)c1ccc2c(c1)C(SCCN1CCN(Cc3ccccc3)CC1)c1ccccc1CO2	10.1021/jm00055a013
		45272878	195861	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	448	7	0	6	4.4	COc1ccc(Cn2c(N3CCC(N(C)CC4CCOCC4)CC3)nc3ccccc32)cc1	10.1016/j.bmcl.2009.05.086
		CHEMBL558663	195861	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	448	7	0	6	4.4	COc1ccc(Cn2c(N3CCC(N(C)CC4CCOCC4)CC3)nc3ccccc32)cc1	10.1016/j.bmcl.2009.05.086
		45270330	196447	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	434	7	1	6	4.1	COc1ccc(Cn2c(N3CCC(NCC4CCOCC4)CC3)nc3ccccc32)cc1	10.1016/j.bmcl.2009.05.086
		CHEMBL563055	196447	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	434	7	1	6	4.1	COc1ccc(Cn2c(N3CCC(NCC4CCOCC4)CC3)nc3ccccc32)cc1	10.1016/j.bmcl.2009.05.086
		25184832	18695	0	None	2	5	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation countingDisplacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation counting	ChEMBL	349	2	1	3	3.8	O=C(O)C1CN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)C1	10.1021/jm100856p
		CHEMBL1277312	18695	0	None	2	5	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation countingDisplacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation counting	ChEMBL	349	2	1	3	3.8	O=C(O)C1CN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)C1	10.1021/jm100856p
		1224	1432	83	None	-2	13	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1016/j.bmcl.2011.09.001
		3100	1432	83	None	-2	13	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1016/j.bmcl.2011.09.001
		8980	1432	83	None	-2	13	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1016/j.bmcl.2011.09.001
		916	1432	83	None	-2	13	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1016/j.bmcl.2011.09.001
		CHEMBL657	1432	83	None	-2	13	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1016/j.bmcl.2011.09.001
		DB01075	1432	83	None	-2	13	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1016/j.bmcl.2011.09.001
		44343629	159949	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	327	1	1	3	2.4	O=C1CN(C2c3ccc(Cl)cc3CCc3cccnc32)CCN1	10.1016/s0960-894x(98)00626-x
		CHEMBL410734	159949	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	327	1	1	3	2.4	O=C1CN(C2c3ccc(Cl)cc3CCc3cccnc32)CCN1	10.1016/s0960-894x(98)00626-x
		10474964	130471	0	None	-181	7	Rat	6.9	pKi	=	6.9	Binding	Inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat cortexInhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat cortex	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
		CHEMBL368061	130471	0	None	-181	7	Rat	6.9	pKi	=	6.9	Binding	Inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat cortexInhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat cortex	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
		CHEMBL5206021	130471	0	None	-181	7	Rat	6.9	pKi	=	6.9	Binding	Inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat cortexInhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat cortex	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
		46782362	150451	27	None	-10	2	Human	6.9	pKi	=	6.9	Binding	Radioligand Binding Assay: The pharmacological profile of metopimazine, metopimazine acid (MPZA), domperidone, and metoclopramide were assessed by radioligand binding and by a functional antagonist assay. For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in buffer. The assay was terminated by rapid filtration, and the bound radioactive signal was determined by liquid scintillation counting.Radioligand Binding Assay: The pharmacological profile of metopimazine, metopimazine acid (MPZA), domperidone, and metoclopramide were assessed by radioligand binding and by a functional antagonist assay. For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in buffer. The assay was terminated by rapid filtration, and the bound radioactive signal was determined by liquid scintillation counting.	ChEMBL	446	6	1	6	3.9	CS(=O)(=O)c1ccc2c(c1)N(CCCN1CCC(C(=O)O)CC1)c1ccccc1S2	nan
		CHEMBL3954123	150451	27	None	-10	2	Human	6.9	pKi	=	6.9	Binding	Radioligand Binding Assay: The pharmacological profile of metopimazine, metopimazine acid (MPZA), domperidone, and metoclopramide were assessed by radioligand binding and by a functional antagonist assay. For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in buffer. The assay was terminated by rapid filtration, and the bound radioactive signal was determined by liquid scintillation counting.Radioligand Binding Assay: The pharmacological profile of metopimazine, metopimazine acid (MPZA), domperidone, and metoclopramide were assessed by radioligand binding and by a functional antagonist assay. For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in buffer. The assay was terminated by rapid filtration, and the bound radioactive signal was determined by liquid scintillation counting.	ChEMBL	446	6	1	6	3.9	CS(=O)(=O)c1ccc2c(c1)N(CCCN1CCC(C(=O)O)CC1)c1ccccc1S2	nan
		11121216	30139	0	None	-707	14	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards Histamine H1 receptorBinding affinity towards Histamine H1 receptor	ChEMBL	335	1	1	2	3.0	C[C@@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
		CHEMBL138989	30139	0	None	-707	14	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards Histamine H1 receptorBinding affinity towards Histamine H1 receptor	ChEMBL	335	1	1	2	3.0	C[C@@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
		71456045	84073	0	None	-1995	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation counting analysisDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation counting analysis	ChEMBL	362	5	1	4	3.6	COc1ccccc1N1CCN(Cc2cc(CO)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		CHEMBL2207635	84073	0	None	-1995	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation counting analysisDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation counting analysis	ChEMBL	362	5	1	4	3.6	COc1ccccc1N1CCN(Cc2cc(CO)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		44334214	4615	0	None	-2344	3	Human	4.9	pKi	=	4.9	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	427	9	1	6	2.6	CC(=O)c1ccc(OCCCN2CC[C@H](NS(=O)(=O)c3ccc(C#N)cc3)C2)cc1	10.1016/s0960-894x(02)00685-6
		CHEMBL102840	4615	0	None	-2344	3	Human	4.9	pKi	=	4.9	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	427	9	1	6	2.6	CC(=O)c1ccc(OCCCN2CC[C@H](NS(=O)(=O)c3ccc(C#N)cc3)C2)cc1	10.1016/s0960-894x(02)00685-6
		44304090	202950	0	None	-301	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	360	8	0	5	2.8	CCOC(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00309-8
		CHEMBL62948	202950	0	None	-301	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	360	8	0	5	2.8	CCOC(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00309-8
		53245590	92399	43	None	-3	4	Human	5.9	pKi	=	5.9	Binding	Binding affinity to histamine H1 receptor (unknown origin)Binding affinity to histamine H1 receptor (unknown origin)	ChEMBL	420	6	0	7	3.9	COc1cc2nc(C3CC3)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC	10.1021/ml400176n
		CHEMBL2431120	92399	43	None	-3	4	Human	5.9	pKi	=	5.9	Binding	Binding affinity to histamine H1 receptor (unknown origin)Binding affinity to histamine H1 receptor (unknown origin)	ChEMBL	420	6	0	7	3.9	COc1cc2nc(C3CC3)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC	10.1021/ml400176n
		16726095	84637	2	None	-1	4	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]pyrilamine from rat cortex histamine H1 receptorDisplacement of [3H]pyrilamine from rat cortex histamine H1 receptor	ChEMBL	379	5	1	4	3.4	COC(=O)C1(c2ccc(C)cc2)CC1CN1CCC(O)(c2ccccc2)CC1	10.1021/jm0611197
		CHEMBL222301	84637	2	None	-1	4	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]pyrilamine from rat cortex histamine H1 receptorDisplacement of [3H]pyrilamine from rat cortex histamine H1 receptor	ChEMBL	379	5	1	4	3.4	COC(=O)C1(c2ccc(C)cc2)CC1CN1CCC(O)(c2ccccc2)CC1	10.1021/jm0611197
		127051844	140847	0	None	-125	9	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	322	6	1	3	2.8	NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3819427	140847	0	None	-125	9	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	322	6	1	3	2.8	NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		4601	206747	35	None	-1	16	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
		CHEMBL1201023	206747	35	None	-1	16	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
		CHEMBL900	206747	35	None	-1	16	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
		168276867	192835	0	None	-1	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	662	11	8	8	4.8	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5174278	192835	0	None	-1	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	662	11	8	8	4.8	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221653	192835	0	None	-1	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	662	11	8	8	4.8	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)c1	10.1021/acs.jmedchem.1c00692
		44304068	102347	0	None	-89	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	441	10	1	5	3.5	N[C@H](CC1CCCCC1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		CHEMBL303737	102347	0	None	-89	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	441	10	1	5	3.5	N[C@H](CC1CCCCC1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		44304760	202901	0	None	-234	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	431	13	1	5	3.7	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@H](N)CC(C)C)CC2)cc1	10.1016/s0960-894x(02)00310-4
		CHEMBL62741	202901	0	None	-234	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	431	13	1	5	3.7	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@H](N)CC(C)C)CC2)cc1	10.1016/s0960-894x(02)00310-4
		9906978	42711	2	None	-28	12	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	361	6	1	3	4.0	O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1	10.1016/j.bmc.2008.06.030
		CHEMBL150161	42711	2	None	-28	12	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	361	6	1	3	4.0	O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1	10.1016/j.bmc.2008.06.030
		9906978	42711	2	None	-28	12	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human cloned histamine H1 receptor by radioligand binding assayBinding affinity to human cloned histamine H1 receptor by radioligand binding assay	ChEMBL	361	6	1	3	4.0	O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1	10.1016/j.bmcl.2006.03.057
		CHEMBL150161	42711	2	None	-28	12	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human cloned histamine H1 receptor by radioligand binding assayBinding affinity to human cloned histamine H1 receptor by radioligand binding assay	ChEMBL	361	6	1	3	4.0	O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1	10.1016/j.bmcl.2006.03.057
		118721930	116094	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting method	ChEMBL	394	3	0	2	5.4	CCCCC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/jm501086v
		CHEMBL3357043	116094	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting method	ChEMBL	394	3	0	2	5.4	CCCCC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/jm501086v
		44335428	4984	0	None	-1	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	358	7	1	5	2.6	CCOC(=O)N1CCN(CCCOc2ccc(-c3c[nH]cn3)cc2)CC1	10.1016/s0960-894x(02)00648-0
		CHEMBL104947	4984	0	None	-1	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	358	7	1	5	2.6	CCOC(=O)N1CCN(CCCOc2ccc(-c3c[nH]cn3)cc2)CC1	10.1016/s0960-894x(02)00648-0
		2865	4143	73	None	-58	53	Human	7.8	pKi	=	7.8	Binding	Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	nan
		59	4143	73	None	-58	53	Human	7.8	pKi	=	7.8	Binding	Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	nan
		60854	4143	73	None	-58	53	Human	7.8	pKi	=	7.8	Binding	Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	nan
		CHEMBL708	4143	73	None	-58	53	Human	7.8	pKi	=	7.8	Binding	Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	nan
		DB00246	4143	73	None	-58	53	Human	7.8	pKi	=	7.8	Binding	Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	nan
		46884641	7914	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	279	5	0	3	3.0	CN(C)CCC1=C(Cc2ncccn2)c2ccccc2C1	10.1016/j.bmcl.2010.02.055
		CHEMBL1090198	7914	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	279	5	0	3	3.0	CN(C)CCC1=C(Cc2ncccn2)c2ccccc2C1	10.1016/j.bmcl.2010.02.055
		12765746	102280	4	None	-69	9	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsDisplacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	344	1	0	3	4.3	CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm100652h
		CHEMBL303313	102280	4	None	-69	9	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsDisplacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	344	1	0	3	4.3	CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm100652h
		11696813	187918	12	None	-3	9	Guinea pig	7.8	pKi	=	7.8	Binding	Displacement of [3H]pyrilamine from histamine H1 receptor in guinea pig cerebellumDisplacement of [3H]pyrilamine from histamine H1 receptor in guinea pig cerebellum	ChEMBL	391	7	1	4	4.1	Cc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1	10.1021/jm800689g
		CHEMBL496739	187918	12	None	-3	9	Guinea pig	7.8	pKi	=	7.8	Binding	Displacement of [3H]pyrilamine from histamine H1 receptor in guinea pig cerebellumDisplacement of [3H]pyrilamine from histamine H1 receptor in guinea pig cerebellum	ChEMBL	391	7	1	4	4.1	Cc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1	10.1021/jm800689g
		44404954	135265	0	None	1	3	Guinea pig	7.8	pKi	=	7.8	Binding	Inhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptorInhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptor	ChEMBL	453	6	1	3	5.6	O=C(O)Cc1ccc2c(c1)/C(=C\CN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2	10.1021/jm00055a013
		CHEMBL372588	135265	0	None	1	3	Guinea pig	7.8	pKi	=	7.8	Binding	Inhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptorInhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptor	ChEMBL	453	6	1	3	5.6	O=C(O)Cc1ccc2c(c1)/C(=C\CN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2	10.1021/jm00055a013
		15749429	202913	0	None	-	1	Guinea pig	7.8	pKi	=	7.8	Binding	The compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMThe compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	351	6	1	3	4.0	CN(C)CC/C=C1/c2ccccc2COc2ccc(CCC(=O)O)cc21	10.1021/jm00089a020
		CHEMBL62790	202913	0	None	-	1	Guinea pig	7.8	pKi	=	7.8	Binding	The compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMThe compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	351	6	1	3	4.0	CN(C)CC/C=C1/c2ccccc2COc2ccc(CCC(=O)O)cc21	10.1021/jm00089a020
		53326727	57770	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	377	7	0	4	4.3	C[C@H](C1=C(CCN(C)CC2CCOCC2)Cc2ccccc21)c1cnccn1	10.1016/j.bmcl.2010.12.053
		CHEMBL1669427	57770	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	377	7	0	4	4.3	C[C@H](C1=C(CCN(C)CC2CCOCC2)Cc2ccccc21)c1cnccn1	10.1016/j.bmcl.2010.12.053
		9914506	81257	0	None	-3	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	515	8	1	5	5.1	N#Cc1ccccc1C[C@@H](C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158769	81257	0	None	-3	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	515	8	1	5	5.1	N#Cc1ccccc1C[C@@H](C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		71072052	81259	0	None	-1	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	515	8	1	5	5.1	N#Cc1ccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158771	81259	0	None	-1	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	515	8	1	5	5.1	N#Cc1ccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1	10.1016/j.bmcl.2012.08.103
		71072081	81261	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	504	8	1	4	5.6	Cc1cccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158773	81261	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	504	8	1	4	5.6	Cc1cccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1	10.1016/j.bmcl.2012.08.103
		71449584	81296	1	None	1	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	476	7	1	4	5.4	O=C(O)Cc1ccccc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158825	81296	1	None	1	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	476	7	1	4	5.4	O=C(O)Cc1ccccc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		69272932	81299	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	492	8	1	5	5.2	O=C(O)COc1ccccc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158828	81299	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	492	8	1	5	5.2	O=C(O)COc1ccccc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		17747460	61329	12	None	-19	4	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	640	14	0	6	7.8	O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1	10.1021/jm100064d
		CHEMBL1767164	61329	12	None	-19	4	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	640	14	0	6	7.8	O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1	10.1021/jm100064d
		59296114	84208	0	None	12	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	480	7	2	6	3.4	O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1cn2cc(F)ccc2n1	10.1016/j.bmcl.2012.09.113
		CHEMBL2208425	84208	0	None	12	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	480	7	2	6	3.4	O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1cn2cc(F)ccc2n1	10.1016/j.bmcl.2012.09.113
		59296111	84087	0	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	480	7	3	5	3.4	O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]nc1C(F)(F)F	10.1016/j.bmcl.2012.09.112
		CHEMBL2207658	84087	0	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	480	7	3	5	3.4	O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]nc1C(F)(F)F	10.1016/j.bmcl.2012.09.112
		23722970	69020	21	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	267	4	1	2	3.4	c1ccc(Cc2ccccc2OC2CCNCC2)cc1	10.1021/acs.jmedchem.6b00981
		CHEMBL1923521	69020	21	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	267	4	1	2	3.4	c1ccc(Cc2ccccc2OC2CCNCC2)cc1	10.1021/acs.jmedchem.6b00981
		CHEMBL3977546	69020	21	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	267	4	1	2	3.4	c1ccc(Cc2ccccc2OC2CCNCC2)cc1	10.1021/acs.jmedchem.6b00981
		44396235	168537	1	None	23	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	281	6	0	2	3.8	c1ccc(Cc2ccccc2OCCN2CCCC2)cc1	10.1021/acs.jmedchem.6b00981
		CHEMBL435505	168537	1	None	23	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	281	6	0	2	3.8	c1ccc(Cc2ccccc2OCCN2CCCC2)cc1	10.1021/acs.jmedchem.6b00981
		2865	4143	73	None	-17	53	Guinea pig	7.8	pKi	=	7.8	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm070516u
		59	4143	73	None	-17	53	Guinea pig	7.8	pKi	=	7.8	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm070516u
		60854	4143	73	None	-17	53	Guinea pig	7.8	pKi	=	7.8	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm070516u
		CHEMBL708	4143	73	None	-17	53	Guinea pig	7.8	pKi	=	7.8	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm070516u
		DB00246	4143	73	None	-17	53	Guinea pig	7.8	pKi	=	7.8	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm070516u
		136229178	82244	0	None	19	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	516	5	1	6	4.5	O=C(c1ccc(-c2noc(=O)[nH]2)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.124
		CHEMBL2171025	82244	0	None	19	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	516	5	1	6	4.5	O=C(c1ccc(-c2noc(=O)[nH]2)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.124
		71451671	82247	0	None	31	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	519	8	2	5	5.0	O=C(O)CCNc1ccccc1C(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.124
		CHEMBL2171028	82247	0	None	31	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	519	8	2	5	5.0	O=C(O)CCNc1ccccc1C(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.124
		17963153	82265	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	525	5	1	5	4.7	Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)cc4Cl)CC3)CC2)cc1	10.1016/j.bmcl.2012.08.124
		CHEMBL2171046	82265	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	525	5	1	5	4.7	Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)cc4Cl)CC3)CC2)cc1	10.1016/j.bmcl.2012.08.124
		10324985	76781	8	None	-112	17	Human	6.8	pKi	=	6.8	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
		CHEMBL199824	76781	8	None	-112	17	Human	6.8	pKi	=	6.8	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
		CHEMBL2068762	76781	8	None	-112	17	Human	6.8	pKi	=	6.8	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
		9913604	204586	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cellsIn vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	492	7	2	5	4.4	NC(=O)N(O)CCC#Cc1ccc(CN2CCN([C@H](c3ccccc3)c3ccc(Cl)cc3)CC2)o1	10.1016/j.bmcl.2004.02.005
		CHEMBL73135	204586	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cellsIn vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	492	7	2	5	4.4	NC(=O)N(O)CCC#Cc1ccc(CN2CCN([C@H](c3ccccc3)c3ccc(Cl)cc3)CC2)o1	10.1016/j.bmcl.2004.02.005
		9913604	204586	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Inhibition constant against histamine H1 receptorInhibition constant against histamine H1 receptor	ChEMBL	492	7	2	5	4.4	NC(=O)N(O)CCC#Cc1ccc(CN2CCN([C@H](c3ccccc3)c3ccc(Cl)cc3)CC2)o1	10.1021/jm058225d
		CHEMBL73135	204586	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Inhibition constant against histamine H1 receptorInhibition constant against histamine H1 receptor	ChEMBL	492	7	2	5	4.4	NC(=O)N(O)CCC#Cc1ccc(CN2CCN([C@H](c3ccccc3)c3ccc(Cl)cc3)CC2)o1	10.1021/jm058225d
		14885627	114820	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	352	0	0	2	4.3	CC(=O)N1CCC(=C2c3cc(Cl)ccc3CCc3cccnc32)CC1	10.1021/jm00105a069
		CHEMBL334127	114820	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	352	0	0	2	4.3	CC(=O)N1CCC(=C2c3cc(Cl)ccc3CCc3cccnc32)CC1	10.1021/jm00105a069
		44334368	109217	0	None	-301	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	506	10	1	5	3.9	O=C(c1ccc(OCCCN2CC[C@H](NS(=O)(=O)c3ccc(Br)cc3)C2)cc1)C1CC1	10.1016/s0960-894x(02)00685-6
		CHEMBL321709	109217	0	None	-301	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	506	10	1	5	3.9	O=C(c1ccc(OCCCN2CC[C@H](NS(=O)(=O)c3ccc(Br)cc3)C2)cc1)C1CC1	10.1016/s0960-894x(02)00685-6
		9848303	111580	0	None	-501	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsDisplacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	487	6	1	6	3.8	Cn1cc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)nn1	10.1021/jm100652h
		CHEMBL328187	111580	0	None	-501	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsDisplacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	487	6	1	6	3.8	Cn1cc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)nn1	10.1021/jm100652h
		168276544	190321	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	742	19	6	8	1.8	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5176319	190321	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	742	19	6	8	1.8	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168276544	190321	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	742	19	6	8	1.8	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5176319	190321	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	742	19	6	8	1.8	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		44304318	203261	0	None	-234	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	373	9	1	5	1.8	C[C@@H](CN)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		CHEMBL64608	203261	0	None	-234	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	373	9	1	5	1.8	C[C@@H](CN)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		118721928	116092	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting method	ChEMBL	378	1	0	2	4.8	C/C=C/C(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/jm501086v
		CHEMBL3357041	116092	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting method	ChEMBL	378	1	0	2	4.8	C/C=C/C(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/jm501086v
		1621	2429	17	None	-301	45	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards Histamine H1 receptorBinding affinity towards Histamine H1 receptor	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
		17	2429	17	None	-301	45	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards Histamine H1 receptorBinding affinity towards Histamine H1 receptor	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
		5761	2429	17	None	-301	45	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards Histamine H1 receptorBinding affinity towards Histamine H1 receptor	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
		CHEMBL263881	2429	17	None	-301	45	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards Histamine H1 receptorBinding affinity towards Histamine H1 receptor	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
		DB04829	2429	17	None	-301	45	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards Histamine H1 receptorBinding affinity towards Histamine H1 receptor	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
		45485535	197621	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation counting	ChEMBL	399	7	1	2	5.6	Cc1ccc(CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1	10.1016/j.bmcl.2009.07.047
		CHEMBL570695	197621	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation counting	ChEMBL	399	7	1	2	5.6	Cc1ccc(CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1	10.1016/j.bmcl.2009.07.047
		3151	1462	97	None	-41	27	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		945	1462	97	None	-41	27	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		965	1462	97	None	-41	27	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		CHEMBL219916	1462	97	None	-41	27	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		DB01184	1462	97	None	-41	27	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		44395741	181581	0	None	-10	10	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	360	6	0	3	4.3	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2008.06.030
		CHEMBL476935	181581	0	None	-10	10	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	360	6	0	3	4.3	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2008.06.030
		CHEMBL558392	181581	0	None	-10	10	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	360	6	0	3	4.3	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2008.06.030
		44307779	203559	0	None	-1348	4	Human	4.8	pKi	=	4.8	Binding	Compound was tested for its binding affinity towards human H1 receptorCompound was tested for its binding affinity towards human H1 receptor	ChEMBL	332	2	0	2	4.7	C(#Cc1c2c(nc3ccccc13)CCCCC2)CCN1CCCCC1	10.1016/s0960-894x(03)00356-1
		CHEMBL66660	203559	0	None	-1348	4	Human	4.8	pKi	=	4.8	Binding	Compound was tested for its binding affinity towards human H1 receptorCompound was tested for its binding affinity towards human H1 receptor	ChEMBL	332	2	0	2	4.7	C(#Cc1c2c(nc3ccccc13)CCCCC2)CCN1CCCCC1	10.1016/s0960-894x(03)00356-1
		168279725	191155	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	728	19	6	8	1.5	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5188589	191155	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	728	19	6	8	1.5	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168292703	192060	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	726	18	5	7	2.9	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5202570	192060	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	726	18	5	7	2.9	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		44335387	108550	0	None	-5	4	Human	6.8	pKi	=	6.8	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	393	7	0	5	3.8	CCOC(=O)N1CCN(CCCOc2ccc(-c3ccc(C#N)cc3)cc2)CC1	10.1016/s0960-894x(02)00648-0
		CHEMBL320178	108550	0	None	-5	4	Human	6.8	pKi	=	6.8	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	393	7	0	5	3.8	CCOC(=O)N1CCN(CCCOc2ccc(-c3ccc(C#N)cc3)cc2)CC1	10.1016/s0960-894x(02)00648-0
		11444350	81265	0	None	-7	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	558	8	1	4	6.3	O=C(O)[C@H](Cc1cccc(C(F)(F)F)c1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158777	81265	0	None	-7	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	558	8	1	4	6.3	O=C(O)[C@H](Cc1cccc(C(F)(F)F)c1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		71451391	81269	0	None	-12	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	472	8	1	4	4.5	Cc1cc(F)ccc1OC1CCN(CC2CCN([C@@H](Cc3ccc(F)cc3)C(=O)O)CC2)CC1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158781	81269	0	None	-12	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	472	8	1	4	4.5	Cc1cc(F)ccc1OC1CCN(CC2CCN([C@@H](Cc3ccc(F)cc3)C(=O)O)CC2)CC1	10.1016/j.bmcl.2012.08.103
		16040671	81279	0	None	-56	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	502	8	1	4	5.4	Cc1cc(Cl)ccc1OC1CCN(CC2CCN([C@@](C)(Cc3ccc(F)cc3)C(=O)O)CC2)CC1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158791	81279	0	None	-56	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	502	8	1	4	5.4	Cc1cc(Cl)ccc1OC1CCN(CC2CCN([C@@](C)(Cc3ccc(F)cc3)C(=O)O)CC2)CC1	10.1016/j.bmcl.2012.08.103
		127051843	140751	0	None	-7	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	0	3	3.6	N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3818200	140751	0	None	-7	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	0	3	3.6	N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		168279725	191155	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	728	19	6	8	1.5	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5188589	191155	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	728	19	6	8	1.5	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168292703	192060	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	726	18	5	7	2.9	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5202570	192060	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	726	18	5	7	2.9	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		44267106	98490	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.	ChEMBL	368	0	1	3	4.0	CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cc(O)cnc32)CC1	10.1016/S0960-894X(00)80290-5
		CHEMBL275993	98490	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.	ChEMBL	368	0	1	3	4.0	CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cc(O)cnc32)CC1	10.1016/S0960-894X(00)80290-5
		44304325	201678	0	None	-74	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	389	11	1	4	3.6	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)NCC)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL60620	201678	0	None	-74	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	389	11	1	4	3.6	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)NCC)CC2)cc1	10.1016/s0960-894x(02)00309-8
		10473209	62674	3	None	-6456	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	352	4	1	5	2.6	CNC(=O)c1cnc(Oc2ccc3c(c2)CCN(C2CCC2)CC3)cn1	10.1016/j.bmcl.2013.09.090
		CHEMBL1783890	62674	3	None	-6456	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	352	4	1	5	2.6	CNC(=O)c1cnc(Oc2ccc3c(c2)CCN(C2CCC2)CC3)cn1	10.1016/j.bmcl.2013.09.090
		127051844	140847	0	None	-125	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	322	6	1	3	2.8	NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3819427	140847	0	None	-125	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	322	6	1	3	2.8	NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		9974306	204474	0	None	-199	4	Guinea pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]mepyramine bound to membranes of CHO cells expressing guinea pig H1 receptorsDisplacement of [3H]mepyramine bound to membranes of CHO cells expressing guinea pig H1 receptors	ChEMBL	336	8	3	2	3.4	S=C(NCCCCCc1c[nH]cn1)NCc1ccc(Cl)cc1	10.1021/jm00012a025
		CHEMBL72372	204474	0	None	-199	4	Guinea pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]mepyramine bound to membranes of CHO cells expressing guinea pig H1 receptorsDisplacement of [3H]mepyramine bound to membranes of CHO cells expressing guinea pig H1 receptors	ChEMBL	336	8	3	2	3.4	S=C(NCCCCCc1c[nH]cn1)NCc1ccc(Cl)cc1	10.1021/jm00012a025
		2061019	55103	17	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	227	5	1	2	2.6	NCCOc1ccccc1Cc1ccccc1	10.1021/acs.jmedchem.6b00981
		CHEMBL1616890	55103	17	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	227	5	1	2	2.6	NCCOc1ccccc1Cc1ccccc1	10.1021/acs.jmedchem.6b00981
		CHEMBL3916710	55103	17	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	227	5	1	2	2.6	NCCOc1ccccc1Cc1ccccc1	10.1021/acs.jmedchem.6b00981
		134142912	154522	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	267	4	1	2	3.4	c1ccc(Cc2cccc(OC3CCNCC3)c2)cc1	10.1021/acs.jmedchem.6b00981
		CHEMBL3913361	154522	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	267	4	1	2	3.4	c1ccc(Cc2cccc(OC3CCNCC3)c2)cc1	10.1021/acs.jmedchem.6b00981
		CHEMBL3990797	154522	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	267	4	1	2	3.4	c1ccc(Cc2cccc(OC3CCNCC3)c2)cc1	10.1021/acs.jmedchem.6b00981
		10802230	56559	0	None	-389	2	Guinea pig	4.8	pKi	=	4.8	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	273	6	1	3	2.6	CN(Cc1ccccc1)C(=O)OCCCc1c[nH]cn1	10.1021/jm9507688
		CHEMBL16404	56559	0	None	-389	2	Guinea pig	4.8	pKi	=	4.8	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	273	6	1	3	2.6	CN(Cc1ccccc1)C(=O)OCCCc1c[nH]cn1	10.1021/jm9507688
		10358195	57460	0	None	-1023	2	Guinea pig	4.8	pKi	=	4.8	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	313	5	2	3	3.6	O=C(Nc1ccc(C(F)(F)F)cc1)OCCCc1c[nH]cn1	10.1021/jm9507688
		CHEMBL16565	57460	0	None	-1023	2	Guinea pig	4.8	pKi	=	4.8	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	313	5	2	3	3.6	O=C(Nc1ccc(C(F)(F)F)cc1)OCCCc1c[nH]cn1	10.1021/jm9507688
		10520238	57564	0	None	-1288	2	Guinea pig	4.8	pKi	=	4.8	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	327	6	2	3	3.3	O=C(NCc1ccc(C(F)(F)F)cc1)OCCCc1c[nH]cn1	10.1021/jm9507688
		CHEMBL16654	57564	0	None	-1288	2	Guinea pig	4.8	pKi	=	4.8	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	327	6	2	3	3.3	O=C(NCc1ccc(C(F)(F)F)cc1)OCCCc1c[nH]cn1	10.1021/jm9507688
		10708894	98633	0	None	-1202	2	Guinea pig	4.8	pKi	=	4.8	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	293	6	2	3	2.9	O=C(NCc1ccc(Cl)cc1)OCCCc1c[nH]cn1	10.1021/jm9507688
		CHEMBL277149	98633	0	None	-1202	2	Guinea pig	4.8	pKi	=	4.8	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	293	6	2	3	2.9	O=C(NCc1ccc(Cl)cc1)OCCCc1c[nH]cn1	10.1021/jm9507688
		10466840	204481	0	None	-1584	4	Guinea pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]mepyramine bound to membranes of CHO cells expressing guinea pig H1 receptorsDisplacement of [3H]mepyramine bound to membranes of CHO cells expressing guinea pig H1 receptors	ChEMBL	240	7	3	2	2.0	CC/N=C(\S)NCCCCCc1c[nH]cn1	10.1021/jm00012a025
		CHEMBL72424	204481	0	None	-1584	4	Guinea pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]mepyramine bound to membranes of CHO cells expressing guinea pig H1 receptorsDisplacement of [3H]mepyramine bound to membranes of CHO cells expressing guinea pig H1 receptors	ChEMBL	240	7	3	2	2.0	CC/N=C(\S)NCCCCCc1c[nH]cn1	10.1021/jm00012a025
		164627020	186408	0	None	-363	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	422	7	4	4	3.4	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(c1ccccc1)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4876025	186408	0	None	-363	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	422	7	4	4	3.4	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(c1ccccc1)c1ccccc1	10.1016/j.ejmech.2021.113190
		25271818	12967	58	None	-1	2	Guinea pig	7.8	pKi	=	7.8	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	337	5	1	3	3.6	CN(C)CC/C=C1/c2ccccc2COc2ccc(CC(=O)O)cc21	10.1021/jm00089a020
		5281071	12967	58	None	-1	2	Guinea pig	7.8	pKi	=	7.8	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	337	5	1	3	3.6	CN(C)CC/C=C1/c2ccccc2COc2ccc(CC(=O)O)cc21	10.1021/jm00089a020
		CHEMBL1189432	12967	58	None	-1	2	Guinea pig	7.8	pKi	=	7.8	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	337	5	1	3	3.6	CN(C)CC/C=C1/c2ccccc2COc2ccc(CC(=O)O)cc21	10.1021/jm00089a020
		CHEMBL1719	12967	58	None	-1	2	Guinea pig	7.8	pKi	=	7.8	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	337	5	1	3	3.6	CN(C)CC/C=C1/c2ccccc2COc2ccc(CC(=O)O)cc21	10.1021/jm00089a020
		44622869	197717	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation counting	ChEMBL	371	5	1	2	5.1	Cc1ccc(CN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1	10.1016/j.bmcl.2009.07.047
		CHEMBL571390	197717	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation counting	ChEMBL	371	5	1	2	5.1	Cc1ccc(CN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1	10.1016/j.bmcl.2009.07.047
		71151588	118258	0	None	-1584	10	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in HEK-293 cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in HEK-293 cells	ChEMBL	518	9	1	7	3.6	NC(=O)c1ccccc1OCCCN1CCN(c2cccc3c2ccn3S(=O)(=O)c2ccccc2)CC1	10.1016/j.ejmech.2014.12.045
		CHEMBL3409256	118258	0	None	-1584	10	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in HEK-293 cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in HEK-293 cells	ChEMBL	518	9	1	7	3.6	NC(=O)c1ccccc1OCCCN1CCN(c2cccc3c2ccn3S(=O)(=O)c2ccccc2)CC1	10.1016/j.ejmech.2014.12.045
		14885632	21003	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	348	1	0	3	3.6	COc1ccc2c(c1)CCc1cccnc1C2=C1CCN(C(C)=O)CC1	10.1021/jm00105a069
		CHEMBL131155	21003	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	348	1	0	3	3.6	COc1ccc2c(c1)CCc1cccnc1C2=C1CCN(C(C)=O)CC1	10.1021/jm00105a069
		44334235	4631	0	None	-1445	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	442	10	1	5	3.4	Cc1ccccc1S(=O)(=O)N[C@H]1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)C1	10.1016/s0960-894x(02)00685-6
		CHEMBL102929	4631	0	None	-1445	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	442	10	1	5	3.4	Cc1ccccc1S(=O)(=O)N[C@H]1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)C1	10.1016/s0960-894x(02)00685-6
		53318873	57764	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	360	7	0	5	4.1	C[C@H](C1=C(CCN(C)Cc2ncco2)Cc2ccccc21)c1cnccn1	10.1016/j.bmcl.2010.12.053
		CHEMBL1669421	57764	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	360	7	0	5	4.1	C[C@H](C1=C(CCN(C)Cc2ncco2)Cc2ccccc21)c1cnccn1	10.1016/j.bmcl.2010.12.053
		44335389	5167	0	None	3	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity at human cortical Histamine 1 receptorBinding affinity at human cortical Histamine 1 receptor	ChEMBL	413	8	0	6	3.8	CCOC(=O)N1CCN(CCCOc2ccc(-c3ccccc3[N+](=O)[O-])cc2)CC1	10.1016/s0960-894x(02)00648-0
		CHEMBL105952	5167	0	None	3	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity at human cortical Histamine 1 receptorBinding affinity at human cortical Histamine 1 receptor	ChEMBL	413	8	0	6	3.8	CCOC(=O)N1CCN(CCCOc2ccc(-c3ccccc3[N+](=O)[O-])cc2)CC1	10.1016/s0960-894x(02)00648-0
		168277076	190474	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	755	21	6	8	2.3	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5178882	190474	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	755	21	6	8	2.3	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		44304014	100785	0	None	-1905	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	431	10	1	6	2.3	CC(C)(C)OC[C@@H](N)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		CHEMBL293033	100785	0	None	-1905	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	431	10	1	6	2.3	CC(C)(C)OC[C@@H](N)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		168277076	190474	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	755	21	6	8	2.3	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5178882	190474	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	755	21	6	8	2.3	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		155528188	171321	0	None	-	1	Guinea pig	6.8	pKi	=	6.8	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysisDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysis	ChEMBL	316	5	0	3	3.0	CC1CCCCN1CCCOc1ccc2c(c1)C(=O)N(C)CC2	10.1016/j.bmcl.2019.04.015
		CHEMBL4461154	171321	0	None	-	1	Guinea pig	6.8	pKi	=	6.8	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysisDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysis	ChEMBL	316	5	0	3	3.0	CC1CCCCN1CCCOc1ccc2c(c1)C(=O)N(C)CC2	10.1016/j.bmcl.2019.04.015
		44304475	202767	0	None	-309	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	348	8	0	5	2.8	CCOC(=O)N1CCN(CCCOc2ccc(C(=O)CC)cc2)CC1	10.1016/s0960-894x(02)00309-8
		CHEMBL62066	202767	0	None	-309	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	348	8	0	5	2.8	CCOC(=O)N1CCN(CCCOc2ccc(C(=O)CC)cc2)CC1	10.1016/s0960-894x(02)00309-8
		164611757	184903	0	None	-22	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	402	8	4	4	2.8	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2sc(N)nc2C)cc1	10.1016/j.ejmech.2021.113190
		CHEMBL4853107	184903	0	None	-22	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	402	8	4	4	2.8	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2sc(N)nc2C)cc1	10.1016/j.ejmech.2021.113190
		44304451	102290	0	None	-977	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	417	12	1	5	3.3	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@H](N)C(C)C)CC2)cc1	10.1016/s0960-894x(02)00310-4
		CHEMBL303369	102290	0	None	-977	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	417	12	1	5	3.3	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@H](N)C(C)C)CC2)cc1	10.1016/s0960-894x(02)00310-4
		71525681	89728	0	None	-2041	6	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H1 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H1 receptor expressed in HEK cells	ChEMBL	298	3	2	6	1.7	CNC1CN(c2nc(N)nc3cc(C4CCCC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376803	89728	0	None	-2041	6	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]histamine from human histamine H1 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H1 receptor expressed in HEK cells	ChEMBL	298	3	2	6	1.7	CNC1CN(c2nc(N)nc3cc(C4CCCC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		71528209	86972	0	None	-257	7	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	465	6	0	3	5.8	CC1=CC(C)=[N+]2C1=C(c1ccc(OCCCN3CCCCC3)cc1)c1c(C)cc(C)n1[B-]2(F)F	10.1021/ml300383n
		CHEMBL2323582	86972	0	None	-257	7	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	465	6	0	3	5.8	CC1=CC(C)=[N+]2C1=C(c1ccc(OCCCN3CCCCC3)cc1)c1c(C)cc(C)n1[B-]2(F)F	10.1021/ml300383n
		44209480	70170	0	None	-151	11	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]pyrilamine from human H1 receptor by liquid scintillation countingDisplacement of [3H]pyrilamine from human H1 receptor by liquid scintillation counting	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2011.12.019
		CHEMBL1940418	70170	0	None	-151	11	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]pyrilamine from human H1 receptor by liquid scintillation countingDisplacement of [3H]pyrilamine from human H1 receptor by liquid scintillation counting	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2011.12.019
		3015863	199757	10	None	1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cellsDisplacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cells	ChEMBL	225	5	1	1	3.6	NCCCC(c1ccccc1)c1ccccc1	10.1016/j.bmc.2009.08.016
		CHEMBL593734	199757	10	None	1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cellsDisplacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cells	ChEMBL	225	5	1	1	3.6	NCCCC(c1ccccc1)c1ccccc1	10.1016/j.bmc.2009.08.016
		57402471	67876	0	None	-15	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	469	8	1	5	4.0	COc1ccc(CN(CCN2CCN(C(=O)c3cc4ccccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		CHEMBL1910378	67876	0	None	-15	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	469	8	1	5	4.0	COc1ccc(CN(CCN2CCN(C(=O)c3cc4ccccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		44304415	202028	0	None	-7079	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	505	13	2	7	3.2	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@@H](CO)NC(=O)OC(C)(C)C)CC2)cc1	10.1016/s0960-894x(02)00310-4
		CHEMBL60837	202028	0	None	-7079	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	505	13	2	7	3.2	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@@H](CO)NC(=O)OC(C)(C)C)CC2)cc1	10.1016/s0960-894x(02)00310-4
		44304431	202941	0	None	-724	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	566	14	1	7	4.9	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@@H](Cc3ccncc3)NC(=O)OC(C)(C)C)CC2)cc1	10.1016/s0960-894x(02)00310-4
		CHEMBL62903	202941	0	None	-724	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	566	14	1	7	4.9	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@@H](Cc3ccncc3)NC(=O)OC(C)(C)C)CC2)cc1	10.1016/s0960-894x(02)00310-4
		164619208	185662	0	None	-588	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	378	6	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccccc1F	10.1016/j.ejmech.2021.113190
		CHEMBL4864852	185662	0	None	-588	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	378	6	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccccc1F	10.1016/j.ejmech.2021.113190
		135398737	958	93	None	2	89	Human	7.8	pKi	=	7.8	Binding	Binding affinity against histamine H1 receptorBinding affinity against histamine H1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0002432
		38	958	93	None	2	89	Human	7.8	pKi	=	7.8	Binding	Binding affinity against histamine H1 receptorBinding affinity against histamine H1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0002432
		722	958	93	None	2	89	Human	7.8	pKi	=	7.8	Binding	Binding affinity against histamine H1 receptorBinding affinity against histamine H1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0002432
		CHEMBL42	958	93	None	2	89	Human	7.8	pKi	=	7.8	Binding	Binding affinity against histamine H1 receptorBinding affinity against histamine H1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0002432
		DB00363	958	93	None	2	89	Human	7.8	pKi	=	7.8	Binding	Binding affinity against histamine H1 receptorBinding affinity against histamine H1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0002432
		46884155	8326	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	324	5	0	3	4.9	Cc1ncccc1[C@@H](C)c1c(CCN(C)C)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		CHEMBL1092813	8326	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	324	5	0	3	4.9	Cc1ncccc1[C@@H](C)c1c(CCN(C)C)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		10075223	23190	0	None	-	1	Guinea pig	7.8	pKi	=	7.8	Binding	Inhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptorInhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptor	ChEMBL	515	8	1	4	6.7	CC(C)(C(=O)O)c1ccc2c(c1)C(SCCN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2	10.1021/jm00055a013
		CHEMBL133127	23190	0	None	-	1	Guinea pig	7.8	pKi	=	7.8	Binding	Inhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptorInhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptor	ChEMBL	515	8	1	4	6.7	CC(C)(C(=O)O)c1ccc2c(c1)C(SCCN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2	10.1021/jm00055a013
		44389302	122933	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity for human Histamine H1 receptor in CHO K1 cellsBinding affinity for human Histamine H1 receptor in CHO K1 cells	ChEMBL	653	13	1	6	7.3	O=C(OCc1ccccc1)N(O)CCC#Cc1ccc(OCCCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1016/j.bmcl.2004.12.023
		CHEMBL360666	122933	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity for human Histamine H1 receptor in CHO K1 cellsBinding affinity for human Histamine H1 receptor in CHO K1 cells	ChEMBL	653	13	1	6	7.3	O=C(OCc1ccccc1)N(O)CCC#Cc1ccc(OCCCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1016/j.bmcl.2004.12.023
		135356876	174074	0	None	7	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human H1 histamine receptor expressed in HEK cells by PDSP assayBinding affinity to human H1 histamine receptor expressed in HEK cells by PDSP assay	ChEMBL	464	5	2	6	5.5	O=C(O)c1cc(-c2ccc(C3CCNCC3)cc2)cc(-n2cc(-c3ccc(Cl)s3)nn2)c1	10.1021/acs.jmedchem.6b00044
		CHEMBL4544251	174074	0	None	7	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human H1 histamine receptor expressed in HEK cells by PDSP assayBinding affinity to human H1 histamine receptor expressed in HEK cells by PDSP assay	ChEMBL	464	5	2	6	5.5	O=C(O)c1cc(-c2ccc(C3CCNCC3)cc2)cc(-n2cc(-c3ccc(Cl)s3)nn2)c1	10.1021/acs.jmedchem.6b00044
		14554127	113325	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting method	ChEMBL	380	2	0	2	5.1	CCCC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/jm501086v
		CHEMBL331603	113325	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting method	ChEMBL	380	2	0	2	5.1	CCCC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/jm501086v
		5624	32693	14	None	-5	10	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	520	5	1	8	4.2	Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2	nan
		CHEMBL1203324	32693	14	None	-5	10	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	520	5	1	8	4.2	Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2	nan
		CHEMBL141343	32693	14	None	-5	10	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	520	5	1	8	4.2	Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2	nan
		57345617	70456	0	None	-186	7	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-Pyrilamine from human histamine H1 receptor by liquid scintillation counterDisplacement of [3H]-Pyrilamine from human histamine H1 receptor by liquid scintillation counter	ChEMBL	387	6	1	2	5.3	OC1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2CCCCc1ccc(F)cc1	10.1016/j.bmc.2012.01.022
		CHEMBL1946123	70456	0	None	-186	7	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-Pyrilamine from human histamine H1 receptor by liquid scintillation counterDisplacement of [3H]-Pyrilamine from human histamine H1 receptor by liquid scintillation counter	ChEMBL	387	6	1	2	5.3	OC1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2CCCCc1ccc(F)cc1	10.1016/j.bmc.2012.01.022
		76518514	113537	0	None	-186	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation countingDisplacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation counting	ChEMBL	387	6	1	2	5.3	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
		CHEMBL3321788	113537	0	None	-186	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation countingDisplacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation counting	ChEMBL	387	6	1	2	5.3	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
		168290077	191413	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	786	21	7	9	1.3	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5192678	191413	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	786	21	7	9	1.3	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		44304319	202634	0	None	-194	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	373	9	1	5	1.8	C[C@H](CN)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		CHEMBL61288	202634	0	None	-194	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	373	9	1	5	1.8	C[C@H](CN)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		132075278	162644	0	None	-30	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-Pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	308	3	0	3	3.1	c1ccc(CN2CCc3cc(N4CCOCC4)ccc3C2)cc1	10.1016/j.ejmech.2018.02.024
		CHEMBL4169752	162644	0	None	-30	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-Pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	308	3	0	3	3.1	c1ccc(CN2CCc3cc(N4CCOCC4)ccc3C2)cc1	10.1016/j.ejmech.2018.02.024
		168290077	191413	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	786	21	7	9	1.3	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5192678	191413	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	786	21	7	9	1.3	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		10354158	52138	0	None	-5	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cellsDisplacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cells	ChEMBL	237	3	1	1	3.5	NCCCC1c2ccccc2Cc2ccccc21	10.1016/j.bmc.2009.08.016
		CHEMBL158780	52138	0	None	-5	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cellsDisplacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cells	ChEMBL	237	3	1	1	3.5	NCCCC1c2ccccc2Cc2ccccc21	10.1016/j.bmc.2009.08.016
		155536609	172219	0	None	-	1	Guinea pig	6.8	pKi	=	6.8	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysisDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysis	ChEMBL	316	5	0	4	1.7	CN1CCc2ccc(OCCCN3CCC(=O)CC3)cc2C1=O	10.1016/j.bmcl.2019.04.015
		CHEMBL4474007	172219	0	None	-	1	Guinea pig	6.8	pKi	=	6.8	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysisDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysis	ChEMBL	316	5	0	4	1.7	CN1CCc2ccc(OCCCN3CCC(=O)CC3)cc2C1=O	10.1016/j.bmcl.2019.04.015
		127051843	140751	0	None	-7	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	0	3	3.6	N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3818200	140751	0	None	-7	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	0	3	3.6	N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		44304288	102207	0	None	-831	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	386	11	0	4	3.8	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)C3CC3)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL302886	102207	0	None	-831	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	386	11	0	4	3.8	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)C3CC3)CC2)cc1	10.1016/s0960-894x(02)00309-8
		46967967	120817	5	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	299	4	0	4	3.4	c1cnc2c(c1)cc([C@@H]1CCCO1)n2CCN1CCCCC1	10.1021/jm2011589
		CHEMBL3557423	120817	5	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	299	4	0	4	3.4	c1cnc2c(c1)cc([C@@H]1CCCO1)n2CCN1CCCCC1	10.1021/jm2011589
		12488	1657	56	None	-2	23	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		941361	1657	56	None	-2	23	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		CHEMBL30008	1657	56	None	-2	23	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		DB04841	1657	56	None	-2	23	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		132356	14677	1	None	-	1	Guinea pig	7.8	pKi	=	7.8	Binding	Inhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptorInhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptor	ChEMBL	473	7	1	4	6.1	O=C(O)c1ccc2c(c1)C(SCCN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2	10.1021/jm00055a013
		CHEMBL1205688	14677	1	None	-	1	Guinea pig	7.8	pKi	=	7.8	Binding	Inhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptorInhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptor	ChEMBL	473	7	1	4	6.1	O=C(O)c1ccc2c(c1)C(SCCN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2	10.1021/jm00055a013
		CHEMBL133778	14677	1	None	-	1	Guinea pig	7.8	pKi	=	7.8	Binding	Inhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptorInhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptor	ChEMBL	473	7	1	4	6.1	O=C(O)c1ccc2c(c1)C(SCCN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2	10.1021/jm00055a013
		135458410	167189	0	None	-3	6	Human	7.7	pKi	=	7.7	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	293	2	2	3	3.5	CC1NC(NCC(F)F)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.078
		CHEMBL429136	167189	0	None	-3	6	Human	7.7	pKi	=	7.7	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	293	2	2	3	3.5	CC1NC(NCC(F)F)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.078
		45272070	195284	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	375	4	0	5	4.3	Fc1ccc(Cn2c(N3CCC(n4cccn4)CC3)nc3ccccc32)cc1	10.1016/j.bmcl.2009.05.086
		CHEMBL551347	195284	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	375	4	0	5	4.3	Fc1ccc(Cn2c(N3CCC(n4cccn4)CC3)nc3ccccc32)cc1	10.1016/j.bmcl.2009.05.086
		4806	4008	88	None	-5	13	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
		7351	4008	88	None	-5	13	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
		9966051	4008	88	None	-5	13	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
		CHEMBL2104993	4008	88	None	-5	13	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
		DB09068	4008	88	None	-5	13	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
		44312748	204765	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cellsIn vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	496	7	2	5	3.8	NC(=O)N(O)CCC#C[C@H]1CC[C@H](CN2CCN([C@H](c3ccccc3)c3ccc(Cl)cc3)CC2)O1	10.1016/j.bmcl.2004.02.005
		CHEMBL74688	204765	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cellsIn vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	496	7	2	5	3.8	NC(=O)N(O)CCC#C[C@H]1CC[C@H](CN2CCN([C@H](c3ccccc3)c3ccc(Cl)cc3)CC2)O1	10.1016/j.bmcl.2004.02.005
		44335185	107391	0	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	446	7	0	4	4.7	CCOC(=O)N1CCN(CCCOc2ccc(-c3ccc(Br)cc3)cc2)CC1	10.1016/s0960-894x(02)00648-0
		CHEMBL317900	107391	0	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	446	7	0	4	4.7	CCOC(=O)N1CCN(CCCOc2ccc(-c3ccc(Br)cc3)cc2)CC1	10.1016/s0960-894x(02)00648-0
		168294445	193010	0	None	1	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	414	6	4	4	2.6	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCC2CCc3nc(N)sc3C2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5208113	193010	0	None	1	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	414	6	4	4	2.6	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCC2CCc3nc(N)sc3C2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222768	193010	0	None	1	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	414	6	4	4	2.6	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCC2CCc3nc(N)sc3C2)cc1	10.1021/acs.jmedchem.1c00692
		168273471	192801	0	None	-12	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	596	17	8	10	0.7	N/C(=N\C(=O)NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5173079	192801	0	None	-12	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	596	17	8	10	0.7	N/C(=N\C(=O)NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221433	192801	0	None	-12	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	596	17	8	10	0.7	N/C(=N\C(=O)NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		168273549	192803	0	None	-1	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	436	6	4	4	4.3	Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5174342	192803	0	None	-1	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	436	6	4	4	4.3	Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221438	192803	0	None	-1	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	436	6	4	4	4.3	Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1	10.1021/acs.jmedchem.1c00692
		76325295	105476	0	None	-234	4	Guinea pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenate after 60 mins by liquid scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenate after 60 mins by liquid scintillation counting	ChEMBL	490	7	0	6	5.9	Cc1c(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)ccc2c3c(c(=O)oc12)CCC3	10.1016/j.ejmech.2014.01.012
		CHEMBL3120696	105476	0	None	-234	4	Guinea pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenate after 60 mins by liquid scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenate after 60 mins by liquid scintillation counting	ChEMBL	490	7	0	6	5.9	Cc1c(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)ccc2c3c(c(=O)oc12)CCC3	10.1016/j.ejmech.2014.01.012
		168288713	191377	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	799	23	7	9	2.0	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5192305	191377	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	799	23	7	9	2.0	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168288713	191377	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	799	23	7	9	2.0	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5192305	191377	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	799	23	7	9	2.0	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		127026018	137492	0	None	3	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	399	5	1	5	3.6	CN1CCN(c2nc(NCCc3ccccc3)nc3c2-c2ccccc2CC3)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL3753985	137492	0	None	3	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	399	5	1	5	3.6	CN1CCN(c2nc(NCCc3ccccc3)nc3c2-c2ccccc2CC3)CC1	10.1016/j.bmcl.2015.12.035
		95198280	162091	0	None	-1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	351	5	1	5	3.4	Cc1oc(-c2ccc3ccccc3c2)nc1CN1CCO[C@H](CCN)C1	10.1021/acs.jmedchem.8b00718
		CHEMBL4160967	162091	0	None	-1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	351	5	1	5	3.4	Cc1oc(-c2ccc3ccccc3c2)nc1CN1CCO[C@H](CCN)C1	10.1021/acs.jmedchem.8b00718
		57403981	70495	0	None	-14	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-Pyrilamine from human histamine H1 receptor by liquid scintillation counterDisplacement of [3H]-Pyrilamine from human histamine H1 receptor by liquid scintillation counter	ChEMBL	426	6	1	4	5.8	OC1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2CCCCc1nc2ccccc2s1	10.1016/j.bmc.2012.01.022
		CHEMBL1946745	70495	0	None	-14	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-Pyrilamine from human histamine H1 receptor by liquid scintillation counterDisplacement of [3H]-Pyrilamine from human histamine H1 receptor by liquid scintillation counter	ChEMBL	426	6	1	4	5.8	OC1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2CCCCc1nc2ccccc2s1	10.1016/j.bmc.2012.01.022
		11653679	181191	1	None	-28	11	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	374	6	0	3	4.7	O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2008.06.030
		CHEMBL476108	181191	1	None	-28	11	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	374	6	0	3	4.7	O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2008.06.030
		10251906	2743	18	None	-1548	8	Human	6.7	pKi	=	6.7	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	427	8	1	4	3.6	IC1=CC(=C(C=C1OC)CCNCC2=C(C=CC=C2)OC)OC	10.1016/j.bmc.2008.04.050
		13550	2743	18	None	-1548	8	Human	6.7	pKi	=	6.7	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	427	8	1	4	3.6	IC1=CC(=C(C=C1OC)CCNCC2=C(C=CC=C2)OC)OC	10.1016/j.bmc.2008.04.050
		CHEMBL1908863	2743	18	None	-1548	8	Human	6.7	pKi	=	6.7	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	427	8	1	4	3.6	IC1=CC(=C(C=C1OC)CCNCC2=C(C=CC=C2)OC)OC	10.1016/j.bmc.2008.04.050
		44313266	204613	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cellsDisplacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cells	ChEMBL	223	2	1	1	2.9	CNCC1c2ccccc2Cc2ccccc21	10.1016/j.bmc.2009.08.016
		CHEMBL73307	204613	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cellsDisplacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cells	ChEMBL	223	2	1	1	2.9	CNCC1c2ccccc2Cc2ccccc21	10.1016/j.bmc.2009.08.016
		9842252	131443	18	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity for H1 histamine receptor expressed in CHO cellsBinding affinity for H1 histamine receptor expressed in CHO cells	ChEMBL	296	1	2	4	1.2	NC(=O)c1cnc2n1CCc1ccccc1C21CCNCC1	10.1021/jm049495j
		CHEMBL369075	131443	18	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity for H1 histamine receptor expressed in CHO cellsBinding affinity for H1 histamine receptor expressed in CHO cells	ChEMBL	296	1	2	4	1.2	NC(=O)c1cnc2n1CCc1ccccc1C21CCNCC1	10.1021/jm049495j
		CHEMBL539843	131443	18	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity for H1 histamine receptor expressed in CHO cellsBinding affinity for H1 histamine receptor expressed in CHO cells	ChEMBL	296	1	2	4	1.2	NC(=O)c1cnc2n1CCc1ccccc1C21CCNCC1	10.1021/jm049495j
		2389	3331	118	None	-46	67	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmc.2008.06.030
		5073	3331	118	None	-46	67	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmc.2008.06.030
		96	3331	118	None	-46	67	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmc.2008.06.030
		CHEMBL85	3331	118	None	-46	67	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmc.2008.06.030
		DB00734	3331	118	None	-46	67	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmc.2008.06.030
		2337	3256	77	None	1	62	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm030480f
		50	3256	77	None	1	62	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm030480f
		5002	3256	77	None	1	62	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm030480f
		CHEMBL716	3256	77	None	1	62	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm030480f
		DB01224	3256	77	None	1	62	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm030480f
		9872445	66779	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsBinding affinity towards human histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	556	6	2	5	5.3	NC(=O)N(O)CCC#Cc1ccc(OCCN2CCC(=C3c4ccc(Cl)cc4CCc4cccnc43)CC2)cc1	10.1016/j.bmcl.2004.08.060
		CHEMBL185905	66779	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsBinding affinity towards human histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	556	6	2	5	5.3	NC(=O)N(O)CCC#Cc1ccc(OCCN2CCC(=C3c4ccc(Cl)cc4CCc4cccnc43)CC2)cc1	10.1016/j.bmcl.2004.08.060
		1588	2325	27	None	-35	44	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		28864	2325	27	None	-35	44	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		43	2325	27	None	-35	44	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		CHEMBL157138	2325	27	None	-35	44	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		DB00589	2325	27	None	-35	44	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		56820088	162118	4	None	169	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	340	4	0	6	3.5	c1ccc(-c2nc(CN3CCCN(c4nccs4)CC3)co2)cc1	10.1021/acs.jmedchem.8b00718
		CHEMBL4161436	162118	4	None	169	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	340	4	0	6	3.5	c1ccc(-c2nc(CN3CCCN(c4nccs4)CC3)co2)cc1	10.1021/acs.jmedchem.8b00718
		59652086	114592	0	None	85	2	Human	7.7	pKi	=	7.7	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000726a HRH1Selectivity interaction (GPCR panel (PDSP screen)) EUB0000726a HRH1	ChEMBL	448	8	2	6	3.6	COc1cccc(CNC(=O)c2nc3scc(CN(C)Cc4ccccc4)c3c(=O)[nH]2)c1	10.6019/CHEMBL5212743
		CHEMBL3337895	114592	0	None	85	2	Human	7.7	pKi	=	7.7	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000726a HRH1Selectivity interaction (GPCR panel (PDSP screen)) EUB0000726a HRH1	ChEMBL	448	8	2	6	3.6	COc1cccc(CNC(=O)c2nc3scc(CN(C)Cc4ccccc4)c3c(=O)[nH]2)c1	10.6019/CHEMBL5212743
		44288945	168915	0	None	-47	7	Human	7.7	pKi	=	7.7	Binding	Selectivity screen against human Histamine H1 receptorSelectivity screen against human Histamine H1 receptor	ChEMBL	485	7	2	3	4.4	CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1	10.1016/s0960-894x(99)00696-4
		CHEMBL43860	168915	0	None	-47	7	Human	7.7	pKi	=	7.7	Binding	Selectivity screen against human Histamine H1 receptorSelectivity screen against human Histamine H1 receptor	ChEMBL	485	7	2	3	4.4	CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1	10.1016/s0960-894x(99)00696-4
		57334102	90508	0	None	-5	5	Guinea pig	7.7	pKi	=	7.7	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysisDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysis	ChEMBL	450	7	0	6	5.4	Cc1cc(=O)oc2cc(OCCCCN3CCC(c4noc5cc(F)ccc45)CC3)ccc12	10.1021/jm400408r
		CHEMBL2387260	90508	0	None	-5	5	Guinea pig	7.7	pKi	=	7.7	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysisDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysis	ChEMBL	450	7	0	6	5.4	Cc1cc(=O)oc2cc(OCCCCN3CCC(c4noc5cc(F)ccc45)CC3)ccc12	10.1021/jm400408r
		71462102	81288	0	None	6	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	478	7	1	5	4.4	O=C(O)C(c1ccccc1)N1CCO[C@@H](CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)C1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158817	81288	0	None	6	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	478	7	1	5	4.4	O=C(O)C(c1ccccc1)N1CCO[C@@H](CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)C1	10.1016/j.bmcl.2012.08.103
		71456725	81298	1	None	1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	476	7	1	4	5.4	O=C(O)Cc1ccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158827	81298	1	None	1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	476	7	1	4	5.4	O=C(O)Cc1ccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1	10.1016/j.bmcl.2012.08.103
		71463288	84204	0	None	6	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	441	8	1	5	5.0	COc1cccc(SC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1	10.1016/j.bmcl.2012.09.113
		CHEMBL2208421	84204	0	None	6	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	441	8	1	5	5.0	COc1cccc(SC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1	10.1016/j.bmcl.2012.09.113
		59296064	84206	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	447	7	2	5	3.5	N#Cc1cccc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1	10.1016/j.bmcl.2012.09.113
		CHEMBL2208423	84206	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	447	7	2	5	3.5	N#Cc1cccc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1	10.1016/j.bmcl.2012.09.113
		59296000	84215	0	None	-7	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	478	6	3	6	3.1	O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)n1c(=O)[nH]c2ccccc21	10.1016/j.bmcl.2012.09.113
		CHEMBL2208432	84215	0	None	-7	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	478	6	3	6	3.1	O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)n1c(=O)[nH]c2ccccc21	10.1016/j.bmcl.2012.09.113
		59295982	84014	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	568	8	4	7	2.1	NS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1	10.1016/j.bmcl.2012.09.112
		CHEMBL2207282	84014	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	568	8	4	7	2.1	NS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1	10.1016/j.bmcl.2012.09.112
		59295925	84101	0	None	-2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	567	8	3	7	2.9	CS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1	10.1016/j.bmcl.2012.09.112
		CHEMBL2207671	84101	0	None	-2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	567	8	3	7	2.9	CS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1	10.1016/j.bmcl.2012.09.112
		71723301	91009	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	392	1	0	2	6.1	Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(C2CCCCC2)CC1	10.1021/acs.jmedchem.9b00447
		CHEMBL2396897	91009	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	392	1	0	2	6.1	Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(C2CCCCC2)CC1	10.1021/acs.jmedchem.9b00447
		25147772	173409	9	None	-6	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in NIH3T3 cellsDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in NIH3T3 cells	ChEMBL	373	4	1	6	3.7	CN1CCN(c2nc(NCc3cccs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL452847	173409	9	None	-6	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in NIH3T3 cellsDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in NIH3T3 cells	ChEMBL	373	4	1	6	3.7	CN1CCN(c2nc(NCc3cccs3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		134151839	152978	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	323	7	0	2	4.9	c1ccc(Cc2ccccc2OCCCN2CCCCCC2)cc1	10.1021/acs.jmedchem.6b00981
		CHEMBL3975229	152978	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	323	7	0	2	4.9	c1ccc(Cc2ccccc2OCCCN2CCCCCC2)cc1	10.1021/acs.jmedchem.6b00981
		49836637	18678	0	None	1	4	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation countingDisplacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation counting	ChEMBL	375	2	1	3	4.5	O=C(O)C1=CCN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)CC1	10.1021/jm100856p
		CHEMBL1277126	18678	0	None	1	4	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation countingDisplacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation counting	ChEMBL	375	2	1	3	4.5	O=C(O)C1=CCN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)CC1	10.1021/jm100856p
		71458868	82232	0	None	-6	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	568	6	1	6	4.8	Cc1c(Cl)ccc(OC2CCN(C3CCN(C(=O)NS(=O)(=O)c4ccc(N(C)C)cc4)CC3)CC2)c1Cl	10.1016/j.bmcl.2012.08.124
		CHEMBL2171014	82232	0	None	-6	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	568	6	1	6	4.8	Cc1c(Cl)ccc(OC2CCN(C3CCN(C(=O)NS(=O)(=O)c4ccc(N(C)C)cc4)CC3)CC2)c1Cl	10.1016/j.bmcl.2012.08.124
		17963363	82254	0	None	-2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	545	5	1	5	5.1	O=C(NS(=O)(=O)c1ccc(Cl)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.124
		CHEMBL2171035	82254	0	None	-2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	545	5	1	5	5.1	O=C(NS(=O)(=O)c1ccc(Cl)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.124
		17963196	82255	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	541	6	1	6	4.4	COc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1	10.1016/j.bmcl.2012.08.124
		CHEMBL2171036	82255	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	541	6	1	6	4.4	COc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1	10.1016/j.bmcl.2012.08.124
		17963258	82256	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	554	6	1	6	4.5	CN(C)c1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1	10.1016/j.bmcl.2012.08.124
		CHEMBL2171037	82256	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	554	6	1	6	4.5	CN(C)c1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1	10.1016/j.bmcl.2012.08.124
		17963332	82259	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	541	6	1	6	4.4	COc1ccccc1S(=O)(=O)NC(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.124
		CHEMBL2171040	82259	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	541	6	1	6	4.4	COc1ccccc1S(=O)(=O)NC(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.124
		17963336	82263	0	None	5	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	536	5	1	6	4.3	N#Cc1cccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1	10.1016/j.bmcl.2012.08.124
		CHEMBL2171044	82263	0	None	5	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	536	5	1	6	4.3	N#Cc1cccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1	10.1016/j.bmcl.2012.08.124
		17963201	82266	0	None	-31	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	539	5	1	5	5.0	Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(C)c4Cl)CC3)CC2)cc1	10.1016/j.bmcl.2012.08.124
		CHEMBL2171047	82266	0	None	-31	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	539	5	1	5	5.0	Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(C)c4Cl)CC3)CC2)cc1	10.1016/j.bmcl.2012.08.124
		14885626	32172	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	414	1	0	2	5.6	O=C(c1ccccc1)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/jm00105a069
		CHEMBL140924	32172	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	414	1	0	2	5.6	O=C(c1ccccc1)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/jm00105a069
		14885631	34940	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	332	0	0	2	3.9	CC(=O)N1CCC(=C2c3ccc(C)cc3CCc3cccnc32)CC1	10.1021/jm00105a069
		CHEMBL143242	34940	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	332	0	0	2	3.9	CC(=O)N1CCC(=C2c3ccc(C)cc3CCc3cccnc32)CC1	10.1021/jm00105a069
		135986088	178115	0	None	-57	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	543	7	1	6	6.5	Clc1ccc2c(c1)N=C(N1CCN(Cc3ccc(OCCCN4CCCCC4)cc3)CC1)c1ccccc1N2	10.1016/j.bmcl.2008.09.012
		CHEMBL464811	178115	0	None	-57	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	543	7	1	6	6.5	Clc1ccc2c(c1)N=C(N1CCN(Cc3ccc(OCCCN4CCCCC4)cc3)CC1)c1ccccc1N2	10.1016/j.bmcl.2008.09.012
		44312371	105483	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cellsIn vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	492	6	2	5	4.4	CC(C#Cc1ccc(CN2CCN([C@H](c3ccccc3)c3ccc(Cl)cc3)CC2)o1)N(O)C(N)=O	10.1016/j.bmcl.2004.02.005
		CHEMBL312082	105483	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cellsIn vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	492	6	2	5	4.4	CC(C#Cc1ccc(CN2CCN([C@H](c3ccccc3)c3ccc(Cl)cc3)CC2)o1)N(O)C(N)=O	10.1016/j.bmcl.2004.02.005
		CHEMBL4576555	214017	5	None	-1	19	Human	5.7	pKi	=	5.7	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000705a HRH1Selectivity interaction (GPCR panel (PDSP screen)) EUB0000705a HRH1	ChEMBL		None	None	None		CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5cc(C(C)(C)C)cc(C(C)(C)C)c5)ccc4n3)cc2)CC1	10.6019/CHEMBL5212743
		CHEMBL4576555	214017	5	None	-1	19	Human	5.7	pKi	=	5.7	Binding	GPCRScan assay: inhibition of H1GPCRScan assay: inhibition of H1	ChEMBL		None	None	None		CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5cc(C(C)(C)C)cc(C(C)(C)C)c5)ccc4n3)cc2)CC1	10.6019/CHEMBL4507307
		44304558	101019	0	None	-602	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	374	11	0	4	3.8	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)CC)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL294502	101019	0	None	-602	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	374	11	0	4	3.8	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)CC)CC2)cc1	10.1016/s0960-894x(02)00309-8
		4023	198	24	None	-660	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	349	7	0	4	3.6	N#Cc1ccc(cc1)c1ccc(cc1)OCCCN1CC[C@H](C1)N(C)C	10.1016/s0960-894x(02)00648-0
		9884746	198	24	None	-660	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	349	7	0	4	3.6	N#Cc1ccc(cc1)c1ccc(cc1)OCCCN1CC[C@H](C1)N(C)C	10.1016/s0960-894x(02)00648-0
		CHEMBL319000	198	24	None	-660	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	349	7	0	4	3.6	N#Cc1ccc(cc1)c1ccc(cc1)OCCCN1CC[C@H](C1)N(C)C	10.1016/s0960-894x(02)00648-0
		127026016	137489	0	None	13	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	385	4	1	5	3.6	CN1CCN(c2nc(NCc3ccccc3)nc3c2-c2ccccc2CC3)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL3753967	137489	0	None	13	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	385	4	1	5	3.6	CN1CCN(c2nc(NCc3ccccc3)nc3c2-c2ccccc2CC3)CC1	10.1016/j.bmcl.2015.12.035
		649745	31482	54	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	303	3	1	7	0.5	C1CCN(c2nc(N3CCCC3)nc(N3CCNCC3)n2)C1	10.1021/jm2011589
		CHEMBL1403257	31482	54	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	303	3	1	7	0.5	C1CCN(c2nc(N3CCCC3)nc(N3CCNCC3)n2)C1	10.1021/jm2011589
		44304450	202867	0	None	-239	3	Human	4.7	pKi	=	4.7	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	417	12	1	5	3.3	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@@H](N)C(C)C)CC2)cc1	10.1016/s0960-894x(02)00310-4
		CHEMBL62592	202867	0	None	-239	3	Human	4.7	pKi	=	4.7	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	417	12	1	5	3.3	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@@H](N)C(C)C)CC2)cc1	10.1016/s0960-894x(02)00310-4
		162665485	182357	0	None	-58	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-pyrilamine from human H1 histamine receptor expressed in human HEK293 cellsDisplacement of [3H]-pyrilamine from human H1 histamine receptor expressed in human HEK293 cells	ChEMBL	468	4	0	3	5.3	C[C@H]1CN(CC[C@H]2CC[C@H](N3C(=O)[C@H]4[C@H]5CC[C@H](C5)[C@H]4C3=O)CC2)CCc2ccc(Cl)cc21	10.1016/j.bmcl.2020.127681
		CHEMBL4784751	182357	0	None	-58	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-pyrilamine from human H1 histamine receptor expressed in human HEK293 cellsDisplacement of [3H]-pyrilamine from human H1 histamine receptor expressed in human HEK293 cells	ChEMBL	468	4	0	3	5.3	C[C@H]1CN(CC[C@H]2CC[C@H](N3C(=O)[C@H]4[C@H]5CC[C@H](C5)[C@H]4C3=O)CC2)CCc2ccc(Cl)cc21	10.1016/j.bmcl.2020.127681
		112936357	137359	1	None	18	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	373	6	1	5	3.6	CN1CCN(c2nc(NCCc3ccccc3)cc(-c3ccccc3)n2)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL3752978	137359	1	None	18	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	373	6	1	5	3.6	CN1CCN(c2nc(NCCc3ccccc3)cc(-c3ccccc3)n2)CC1	10.1016/j.bmcl.2015.12.035
		127035837	137417	0	None	5	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	403	4	1	5	3.7	CN1CCN(c2nc(NCc3ccc(F)cc3)nc3c2CCc2ccccc2-3)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL3753334	137417	0	None	5	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	403	4	1	5	3.7	CN1CCN(c2nc(NCc3ccc(F)cc3)nc3c2CCc2ccccc2-3)CC1	10.1016/j.bmcl.2015.12.035
		164626370	186473	0	None	-1	6	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	338	6	4	4	1.8	CCCCCCNC(=O)/N=C(\N)NC1CCc2nc(N)sc2C1	10.1016/j.ejmech.2021.113190
		CHEMBL4876799	186473	0	None	-1	6	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	338	6	4	4	1.8	CCCCCCNC(=O)/N=C(\N)NC1CCc2nc(N)sc2C1	10.1016/j.ejmech.2021.113190
		18382725	116090	27	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting method	ChEMBL	412	2	0	4	4.9	CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cc(OC)cnc32)CC1	10.1021/jm501086v
		CHEMBL3357024	116090	27	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting method	ChEMBL	412	2	0	4	4.9	CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cc(OC)cnc32)CC1	10.1021/jm501086v
		10398175	180091	7	None	-6	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cellsDisplacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cells	ChEMBL	209	1	1	1	2.7	NCC1c2ccccc2Cc2ccccc21	10.1016/j.bmc.2009.08.016
		CHEMBL47482	180091	7	None	-6	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cellsDisplacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cells	ChEMBL	209	1	1	1	2.7	NCC1c2ccccc2Cc2ccccc21	10.1016/j.bmc.2009.08.016
		162644910	179411	0	None	-18	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cell membranes co-expressing RGS4 measured after 60 mins by scintillation counting analysisDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cell membranes co-expressing RGS4 measured after 60 mins by scintillation counting analysis	ChEMBL	407	7	0	4	5.0	Clc1cccc(-c2ccc(OCCCN3CCN(c4ccncc4)CC3)cc2)c1	10.1016/j.ejmech.2020.113041
		CHEMBL4740135	179411	0	None	-18	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cell membranes co-expressing RGS4 measured after 60 mins by scintillation counting analysisDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cell membranes co-expressing RGS4 measured after 60 mins by scintillation counting analysis	ChEMBL	407	7	0	4	5.0	Clc1cccc(-c2ccc(OCCCN3CCN(c4ccncc4)CC3)cc2)c1	10.1016/j.ejmech.2020.113041
		46882181	5681	0	None	1	5	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	536	10	2	8	5.1	CCOc1cc(CN2CCC(Nc3nc4cc(NS(=O)(=O)c5ccccc5)ccc4o3)CC2)ccc1OC	10.1016/j.bmcl.2009.09.024
		CHEMBL1077908	5681	0	None	1	5	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	536	10	2	8	5.1	CCOc1cc(CN2CCC(Nc3nc4cc(NS(=O)(=O)c5ccccc5)ccc4o3)CC2)ccc1OC	10.1016/j.bmcl.2009.09.024
		66615691	81277	0	None	-125	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	518	8	1	4	5.9	Cc1c(OC2CCN(CC3CCN([C@@](C)(Cc4ccccc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl	10.1016/j.bmcl.2012.08.103
		CHEMBL2158789	81277	0	None	-125	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	518	8	1	4	5.9	Cc1c(OC2CCN(CC3CCN([C@@](C)(Cc4ccccc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl	10.1016/j.bmcl.2012.08.103
		59296109	84211	0	None	-12	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	500	8	2	6	3.0	CS(=O)(=O)c1ccccc1C(=O)NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1	10.1016/j.bmcl.2012.09.113
		CHEMBL2208428	84211	0	None	-12	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	500	8	2	6	3.0	CS(=O)(=O)c1ccccc1C(=O)NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1	10.1016/j.bmcl.2012.09.113
		127051845	140729	0	None	-12	9	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	309	6	0	3	3.7	COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3817898	140729	0	None	-12	9	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	309	6	0	3	3.7	COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		71462391	82251	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	554	6	1	6	3.9	CS(=O)(=O)c1cccc(C(=O)N2CC[C@@H](N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)[C@H](C(=O)O)C2)c1	10.1016/j.bmcl.2012.08.124
		CHEMBL2171032	82251	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	554	6	1	6	3.9	CS(=O)(=O)c1cccc(C(=O)N2CC[C@@H](N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)[C@H](C(=O)O)C2)c1	10.1016/j.bmcl.2012.08.124
		46881463	7218	0	None	-501	5	Human	5.7	pKi	=	5.7	Binding	Activity at histamine H1 receptorActivity at histamine H1 receptor	ChEMBL	293	3	1	2	2.7	O=C1N(CC2CCCCN2)CCN1c1cccc(Cl)c1	10.1016/j.bmcl.2010.01.090
		CHEMBL1085672	7218	0	None	-501	5	Human	5.7	pKi	=	5.7	Binding	Activity at histamine H1 receptorActivity at histamine H1 receptor	ChEMBL	293	3	1	2	2.7	O=C1N(CC2CCCCN2)CCN1c1cccc(Cl)c1	10.1016/j.bmcl.2010.01.090
		9798145	104133	0	None	-3981	2	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced effect by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced effect by FLIPR assay	ChEMBL	342	7	0	3	3.8	c1cc2c(cc1OCCCN1CCCCC1)CCN(CC1CC1)CC2	10.1016/j.bmcl.2013.09.089
		CHEMBL3094215	104133	0	None	-3981	2	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced effect by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced effect by FLIPR assay	ChEMBL	342	7	0	3	3.8	c1cc2c(cc1OCCCN1CCCCC1)CCN(CC1CC1)CC2	10.1016/j.bmcl.2013.09.089
		10429386	104134	0	None	-3981	2	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced effect by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced effect by FLIPR assay	ChEMBL	372	7	0	4	3.5	c1cc2c(cc1OCCCN1CCCCC1)CCN(CC1CCCO1)CC2	10.1016/j.bmcl.2013.09.089
		CHEMBL3094216	104134	0	None	-3981	2	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced effect by FLIPR assayAntagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced effect by FLIPR assay	ChEMBL	372	7	0	4	3.5	c1cc2c(cc1OCCCN1CCCCC1)CCN(CC1CCCO1)CC2	10.1016/j.bmcl.2013.09.089
		44304294	202963	0	None	-9	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	485	10	1	5	3.9	N[C@H](Cc1cccc2ccccc12)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		CHEMBL63003	202963	0	None	-9	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	485	10	1	5	3.9	N[C@H](Cc1cccc2ccccc12)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		10565409	52189	0	None	-977	2	Guinea pig	4.7	pKi	=	4.7	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	290	6	2	5	2.5	O=C(Nc1ccc([N+](=O)[O-])cc1)OCCCc1c[nH]cn1	10.1021/jm9507688
		CHEMBL15883	52189	0	None	-977	2	Guinea pig	4.7	pKi	=	4.7	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	290	6	2	5	2.5	O=C(Nc1ccc([N+](=O)[O-])cc1)OCCCc1c[nH]cn1	10.1021/jm9507688
		5250783	169387	3	None	-1995	3	Guinea pig	4.7	pKi	=	4.7	Binding	Displacement of [3H]mepyramine bound to membranes of CHO cells expressing guinea pig H1 receptorsDisplacement of [3H]mepyramine bound to membranes of CHO cells expressing guinea pig H1 receptors	ChEMBL	226	6	3	2	1.6	C/N=C(\S)NCCCCCc1c[nH]cn1	10.1021/jm00012a025
		CHEMBL44220	169387	3	None	-1995	3	Guinea pig	4.7	pKi	=	4.7	Binding	Displacement of [3H]mepyramine bound to membranes of CHO cells expressing guinea pig H1 receptorsDisplacement of [3H]mepyramine bound to membranes of CHO cells expressing guinea pig H1 receptors	ChEMBL	226	6	3	2	1.6	C/N=C(\S)NCCCCCc1c[nH]cn1	10.1021/jm00012a025
		1204	1932	119	None	-501	24	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor N7.45C mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor N7.45C mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1038/nchembio714
		1247	1932	119	None	-501	24	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor N7.45C mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor N7.45C mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1038/nchembio714
		1375	1932	119	None	-501	24	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor N7.45C mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor N7.45C mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1038/nchembio714
		774	1932	119	None	-501	24	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor N7.45C mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor N7.45C mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1038/nchembio714
		CHEMBL90	1932	119	None	-501	24	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor N7.45C mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor N7.45C mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1038/nchembio714
		DB05381	1932	119	None	-501	24	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor N7.45C mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor N7.45C mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1038/nchembio714
		1210	918	51	None	-9	21	Rat	8.7	pKi	=	8.7	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/s0960-894x(03)00357-3
		1213	918	51	None	-9	21	Rat	8.7	pKi	=	8.7	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/s0960-894x(03)00357-3
		2725	918	51	None	-9	21	Rat	8.7	pKi	=	8.7	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/s0960-894x(03)00357-3
		33036	918	51	None	-9	21	Rat	8.7	pKi	=	8.7	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/s0960-894x(03)00357-3
		4411	918	51	None	-9	21	Rat	8.7	pKi	=	8.7	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/s0960-894x(03)00357-3
		616	918	51	None	-9	21	Rat	8.7	pKi	=	8.7	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/s0960-894x(03)00357-3
		6976	918	51	None	-9	21	Rat	8.7	pKi	=	8.7	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/s0960-894x(03)00357-3
		716121	918	51	None	-9	21	Rat	8.7	pKi	=	8.7	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/s0960-894x(03)00357-3
		CHEMBL1201353	918	51	None	-9	21	Rat	8.7	pKi	=	8.7	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/s0960-894x(03)00357-3
		CHEMBL1554789	918	51	None	-9	21	Rat	8.7	pKi	=	8.7	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/s0960-894x(03)00357-3
		CHEMBL505	918	51	None	-9	21	Rat	8.7	pKi	=	8.7	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/s0960-894x(03)00357-3
		DB01114	918	51	None	-9	21	Rat	8.7	pKi	=	8.7	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/s0960-894x(03)00357-3
		DB13679	918	51	None	-9	21	Rat	8.7	pKi	=	8.7	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/s0960-894x(03)00357-3
		135398745	2914	112	None	1	65	Human	8.7	pKi	=	8.7	Binding	Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		47	2914	112	None	1	65	Human	8.7	pKi	=	8.7	Binding	Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		CHEMBL715	2914	112	None	1	65	Human	8.7	pKi	=	8.7	Binding	Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		DB00334	2914	112	None	1	65	Human	8.7	pKi	=	8.7	Binding	Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		1400	1957	70	None	2	3	Human	8.7	pKi	=	8.7	Binding	Binding affinity to histamine H1 receptor (unknown origin)Binding affinity to histamine H1 receptor (unknown origin)	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1016/j.bmcl.2018.04.059
		3658	1957	70	None	2	3	Human	8.7	pKi	=	8.7	Binding	Binding affinity to histamine H1 receptor (unknown origin)Binding affinity to histamine H1 receptor (unknown origin)	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1016/j.bmcl.2018.04.059
		7199	1957	70	None	2	3	Human	8.7	pKi	=	8.7	Binding	Binding affinity to histamine H1 receptor (unknown origin)Binding affinity to histamine H1 receptor (unknown origin)	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1016/j.bmcl.2018.04.059
		91513	1957	70	None	2	3	Human	8.7	pKi	=	8.7	Binding	Binding affinity to histamine H1 receptor (unknown origin)Binding affinity to histamine H1 receptor (unknown origin)	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1016/j.bmcl.2018.04.059
		CHEMBL896	1957	70	None	2	3	Human	8.7	pKi	=	8.7	Binding	Binding affinity to histamine H1 receptor (unknown origin)Binding affinity to histamine H1 receptor (unknown origin)	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1016/j.bmcl.2018.04.059
		DB00557	1957	70	None	2	3	Human	8.7	pKi	=	8.7	Binding	Binding affinity to histamine H1 receptor (unknown origin)Binding affinity to histamine H1 receptor (unknown origin)	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1016/j.bmcl.2018.04.059
		135398745	2914	112	None	1	65	Human	8.7	pKi	=	8.7	Binding	Inhibition of histamine H1 receptor (unknown origin)Inhibition of histamine H1 receptor (unknown origin)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm401958n
		47	2914	112	None	1	65	Human	8.7	pKi	=	8.7	Binding	Inhibition of histamine H1 receptor (unknown origin)Inhibition of histamine H1 receptor (unknown origin)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm401958n
		CHEMBL715	2914	112	None	1	65	Human	8.7	pKi	=	8.7	Binding	Inhibition of histamine H1 receptor (unknown origin)Inhibition of histamine H1 receptor (unknown origin)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm401958n
		DB00334	2914	112	None	1	65	Human	8.7	pKi	=	8.7	Binding	Inhibition of histamine H1 receptor (unknown origin)Inhibition of histamine H1 receptor (unknown origin)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm401958n
		2247	505	81	None	-4	42	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1016/j.bmcl.2011.09.001
		249	505	81	None	-4	42	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1016/j.bmcl.2011.09.001
		2603	505	81	None	-4	42	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1016/j.bmcl.2011.09.001
		CHEMBL296419	505	81	None	-4	42	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1016/j.bmcl.2011.09.001
		DB00637	505	81	None	-4	42	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1016/j.bmcl.2011.09.001
		1227	2489	43	None	-2	12	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm2011589
		2331	2489	43	None	-2	12	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm2011589
		3957	2489	43	None	-2	12	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm2011589
		4992	2489	43	None	-2	12	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm2011589
		CHEMBL511	2489	43	None	-2	12	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm2011589
		DB06691	2489	43	None	-2	12	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm2011589
		11688223	8302	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	313	5	0	3	3.6	CN(C)CCC1=C(Cc2cccnn2)c2ccc(Cl)cc2C1	10.1016/j.bmcl.2010.02.055
		CHEMBL1092652	8302	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	313	5	0	3	3.6	CN(C)CCC1=C(Cc2cccnn2)c2ccc(Cl)cc2C1	10.1016/j.bmcl.2010.02.055
		135398737	958	93	None	2	89	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030480f
		38	958	93	None	2	89	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030480f
		722	958	93	None	2	89	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030480f
		CHEMBL42	958	93	None	2	89	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030480f
		DB00363	958	93	None	2	89	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030480f
		155561547	175656	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	364	1	0	2	5.3	Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(C2CCC2)CC1	10.1021/acs.jmedchem.9b00447
		CHEMBL4581343	175656	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	364	1	0	2	5.3	Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(C2CCC2)CC1	10.1021/acs.jmedchem.9b00447
		46884639	7725	0	None	6918	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	309	6	0	4	3.0	COc1nccnc1CC1=C(CCN(C)C)Cc2ccccc21	10.1016/j.bmcl.2010.02.055
		CHEMBL1088900	7725	0	None	6918	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	309	6	0	4	3.0	COc1nccnc1CC1=C(CCN(C)C)Cc2ccccc21	10.1016/j.bmcl.2010.02.055
		46884736	7974	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	312	5	0	3	4.5	Cc1ccc2c(c1)CC(CCN(C)C)=C2[C@@H](C)c1nccs1	10.1016/j.bmcl.2010.02.055
		CHEMBL1090528	7974	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	312	5	0	3	4.5	Cc1ccc2c(c1)CC(CCN(C)C)=C2[C@@H](C)c1nccs1	10.1016/j.bmcl.2010.02.055
		45272046	195161	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	396	7	0	5	3.8	COCCN(C)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1	10.1016/j.bmcl.2009.05.086
		CHEMBL550337	195161	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	396	7	0	5	3.8	COCCN(C)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1	10.1016/j.bmcl.2009.05.086
		1227	2489	43	None	-2	12	Human	8.7	pKi	=	8.7	Binding	Displacement of radiolabeled pyrilamine from human histamine H1 receptorDisplacement of radiolabeled pyrilamine from human histamine H1 receptor	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm8007618
		2331	2489	43	None	-2	12	Human	8.7	pKi	=	8.7	Binding	Displacement of radiolabeled pyrilamine from human histamine H1 receptorDisplacement of radiolabeled pyrilamine from human histamine H1 receptor	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm8007618
		3957	2489	43	None	-2	12	Human	8.7	pKi	=	8.7	Binding	Displacement of radiolabeled pyrilamine from human histamine H1 receptorDisplacement of radiolabeled pyrilamine from human histamine H1 receptor	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm8007618
		4992	2489	43	None	-2	12	Human	8.7	pKi	=	8.7	Binding	Displacement of radiolabeled pyrilamine from human histamine H1 receptorDisplacement of radiolabeled pyrilamine from human histamine H1 receptor	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm8007618
		CHEMBL511	2489	43	None	-2	12	Human	8.7	pKi	=	8.7	Binding	Displacement of radiolabeled pyrilamine from human histamine H1 receptorDisplacement of radiolabeled pyrilamine from human histamine H1 receptor	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm8007618
		DB06691	2489	43	None	-2	12	Human	8.7	pKi	=	8.7	Binding	Displacement of radiolabeled pyrilamine from human histamine H1 receptorDisplacement of radiolabeled pyrilamine from human histamine H1 receptor	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1021/jm8007618
		44326390	207847	0	None	11	3	Human	8.6	pKi	=	8.6	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	335	2	0	3	3.5	c1ccc2c(c1)Cc1ccccc1[C@H]1CC(CN3CCOCC3)O[C@H]21	10.1016/j.bmcl.2004.03.069
		CHEMBL96429	207847	0	None	11	3	Human	8.6	pKi	=	8.6	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	335	2	0	3	3.5	c1ccc2c(c1)Cc1ccccc1[C@H]1CC(CN3CCOCC3)O[C@H]21	10.1016/j.bmcl.2004.03.069
		135398737	958	93	None	2	89	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2008.09.012
		38	958	93	None	2	89	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2008.09.012
		722	958	93	None	2	89	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2008.09.012
		CHEMBL42	958	93	None	2	89	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2008.09.012
		DB00363	958	93	None	2	89	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2008.09.012
		15595033	195075	20	None	416	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	338	4	1	4	3.4	CNC1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1	10.1016/j.bmcl.2009.05.086
		CHEMBL549599	195075	20	None	416	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	338	4	1	4	3.4	CNC1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1	10.1016/j.bmcl.2009.05.086
		45272877	195845	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	364	5	0	5	3.6	COc1ccc(Cn2c(N3CCC(N(C)C)CC3)nc3ccccc32)cc1	10.1016/j.bmcl.2009.05.086
		CHEMBL558468	195845	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	364	5	0	5	3.6	COc1ccc(Cn2c(N3CCC(N(C)C)CC3)nc3ccccc32)cc1	10.1016/j.bmcl.2009.05.086
		45268662	195950	0	None	37	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	442	7	0	4	5.4	CN(CCc1ccccc1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1	10.1016/j.bmcl.2009.05.086
		CHEMBL559557	195950	0	None	37	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	442	7	0	4	5.4	CN(CCc1ccccc1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1	10.1016/j.bmcl.2009.05.086
		46865978	8439	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	328	6	0	4	4.2	COc1ccc2c(c1)CC(CCN(C)C)=C2[C@@H](C)c1nccs1	10.1016/j.bmcl.2010.02.055
		CHEMBL1093623	8439	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	328	6	0	4	4.2	COc1ccc2c(c1)CC(CCN(C)C)=C2[C@@H](C)c1nccs1	10.1016/j.bmcl.2010.02.055
		49782792	17911	0	None	-7	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsDisplacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	381	3	1	4	3.3	CC(=O)NCc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2	10.1021/jm100652h
		CHEMBL1259174	17911	0	None	-7	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsDisplacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	381	3	1	4	3.3	CC(=O)NCc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2	10.1021/jm100652h
		59296081	84083	0	None	-7	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	608	9	3	7	2.9	O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(S(=O)(=O)N3CCC3)ccc12	10.1016/j.bmcl.2012.09.112
		CHEMBL2207654	84083	0	None	-7	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	608	9	3	7	2.9	O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(S(=O)(=O)N3CCC3)ccc12	10.1016/j.bmcl.2012.09.112
		59295978	84085	0	None	-1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	507	7	3	5	3.6	O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2c(F)cccc12	10.1016/j.bmcl.2012.09.112
		CHEMBL2207656	84085	0	None	-1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	507	7	3	5	3.6	O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2c(F)cccc12	10.1016/j.bmcl.2012.09.112
		59295968	84086	0	None	-3	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	487	7	3	5	3.3	Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3c(F)cccc23)CC1	10.1016/j.bmcl.2012.09.112
		CHEMBL2207657	84086	0	None	-3	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	487	7	3	5	3.3	Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3c(F)cccc23)CC1	10.1016/j.bmcl.2012.09.112
		155556183	174488	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	406	2	0	2	6.3	Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(CC2CCCCC2)CC1	10.1021/acs.jmedchem.9b00447
		CHEMBL4554533	174488	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	406	2	0	2	6.3	Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(CC2CCCCC2)CC1	10.1021/acs.jmedchem.9b00447
		134134675	154583	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	315	4	0	2	4.4	CN1CCC(Oc2ccccc2Cc2ccc(Cl)cc2)CC1	10.1021/acs.jmedchem.6b00981
		CHEMBL3905009	154583	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	315	4	0	2	4.4	CN1CCC(Oc2ccccc2Cc2ccc(Cl)cc2)CC1	10.1021/acs.jmedchem.6b00981
		CHEMBL3991348	154583	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	315	4	0	2	4.4	CN1CCC(Oc2ccccc2Cc2ccc(Cl)cc2)CC1	10.1021/acs.jmedchem.6b00981
		17963227	82231	0	None	39	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	539	5	0	5	5.1	Cc1ccc(S(=O)(=O)N(C)C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1	10.1016/j.bmcl.2012.08.124
		CHEMBL2171013	82231	0	None	39	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	539	5	0	5	5.1	Cc1ccc(S(=O)(=O)N(C)C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1	10.1016/j.bmcl.2012.08.124
		2600	3779	74	None	1	13	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		2608	3779	74	None	1	13	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		5405	3779	74	None	1	13	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		CHEMBL17157	3779	74	None	1	13	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		DB00342	3779	74	None	1	13	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		136152971	95357	0	None	-1	6	Human	8.6	pKi	=	8.6	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	293	2	2	3	3.5	C[C@@H]1NC(NCC(F)F)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.078
		CHEMBL256694	95357	0	None	-1	6	Human	8.6	pKi	=	8.6	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	293	2	2	3	3.5	C[C@@H]1NC(NCC(F)F)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.078
		2389	3331	118	None	-46	67	Human	8.6	pKi	=	8.6	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm030480f
		5073	3331	118	None	-46	67	Human	8.6	pKi	=	8.6	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm030480f
		96	3331	118	None	-46	67	Human	8.6	pKi	=	8.6	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm030480f
		CHEMBL85	3331	118	None	-46	67	Human	8.6	pKi	=	8.6	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm030480f
		DB00734	3331	118	None	-46	67	Human	8.6	pKi	=	8.6	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm030480f
		46884732	7910	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	337	6	0	4	3.9	COc1nccnc1[C@H](C)C1=C(CCN(C)C)Cc2cc(C)ccc21	10.1016/j.bmcl.2010.02.055
		CHEMBL1090176	7910	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	337	6	0	4	3.9	COc1nccnc1[C@H](C)C1=C(CCN(C)C)Cc2cc(C)ccc21	10.1016/j.bmcl.2010.02.055
		46884152	8252	0	None	812	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	328	5	0	3	4.7	C[C@@H](c1ncccc1F)c1c(CCN(C)C)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		CHEMBL1092377	8252	0	None	812	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	328	5	0	3	4.7	C[C@@H](c1ncccc1F)c1c(CCN(C)C)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		10102	2546	88	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	10.1016/j.bmcl.2009.05.086
		1824	2546	88	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	10.1016/j.bmcl.2009.05.086
		65906	2546	88	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	10.1016/j.bmcl.2009.05.086
		CHEMBL94454	2546	88	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	10.1016/j.bmcl.2009.05.086
		DB12523	2546	88	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	10.1016/j.bmcl.2009.05.086
		9857902	60804	0	None	6	5	Rat	8.6	pKi	=	8.6	Binding	In vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamineIn vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamine	ChEMBL	311	1	0	4	3.5	Cc1ccc2n1C=C(N1CCN(C)CC1)c1ccccc1S2	10.1021/jm0309811
		CHEMBL176169	60804	0	None	6	5	Rat	8.6	pKi	=	8.6	Binding	In vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamineIn vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamine	ChEMBL	311	1	0	4	3.5	Cc1ccc2n1C=C(N1CCN(C)CC1)c1ccccc1S2	10.1021/jm0309811
		9796255	129048	0	None	-2	8	Rat	8.6	pKi	=	8.6	Binding	In vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamineIn vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamine	ChEMBL	297	1	0	4	3.2	CN1CCN(C2=Cn3cccc3Sc3ccccc32)CC1	10.1021/jm0309811
		CHEMBL367045	129048	0	None	-2	8	Rat	8.6	pKi	=	8.6	Binding	In vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamineIn vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamine	ChEMBL	297	1	0	4	3.2	CN1CCN(C2=Cn3cccc3Sc3ccccc32)CC1	10.1021/jm0309811
		46884732	7910	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	337	6	0	4	3.9	COc1nccnc1[C@H](C)C1=C(CCN(C)C)Cc2cc(C)ccc21	10.1016/j.bmcl.2010.07.117
		CHEMBL1090176	7910	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	337	6	0	4	3.9	COc1nccnc1[C@H](C)C1=C(CCN(C)C)Cc2cc(C)ccc21	10.1016/j.bmcl.2010.07.117
		2274	3173	58	None	-3	31	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		4917	3173	58	None	-3	31	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		7279	3173	58	None	-3	31	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		CHEMBL728	3173	58	None	-3	31	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		DB00433	3173	58	None	-3	31	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		53318872	57756	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	305	5	0	3	3.5	c1ccc2c(c1)CC(CCN1CCCC1)=C2Cc1cnccn1	10.1016/j.bmcl.2010.12.053
		CHEMBL1669413	57756	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	305	5	0	3	3.5	c1ccc2c(c1)CC(CCN1CCCC1)=C2Cc1cnccn1	10.1016/j.bmcl.2010.12.053
		135398745	2914	112	None	1	65	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmc.2008.06.030
		47	2914	112	None	1	65	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmc.2008.06.030
		CHEMBL715	2914	112	None	1	65	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmc.2008.06.030
		DB00334	2914	112	None	1	65	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmc.2008.06.030
		45273833	195888	0	None	977	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	420	5	0	4	5.5	CN(C1CCCCC1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1	10.1016/j.bmcl.2009.05.086
		CHEMBL558933	195888	0	None	977	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	420	5	0	4	5.5	CN(C1CCCCC1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1	10.1016/j.bmcl.2009.05.086
		2389	3331	118	None	-46	67	Human	8.5	pKi	=	8.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		5073	3331	118	None	-46	67	Human	8.5	pKi	=	8.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		96	3331	118	None	-46	67	Human	8.5	pKi	=	8.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		CHEMBL85	3331	118	None	-46	67	Human	8.5	pKi	=	8.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		DB00734	3331	118	None	-46	67	Human	8.5	pKi	=	8.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		46884200	8322	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	344	5	0	3	5.2	C[C@H](c1cccnc1Cl)c1c(CCN(C)C)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		CHEMBL1092766	8322	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	344	5	0	3	5.2	C[C@H](c1cccnc1Cl)c1c(CCN(C)C)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		11695811	8391	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	340	6	0	4	4.6	COc1ncccc1[C@@H](C)c1c(CCN(C)C)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		CHEMBL1093294	8391	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	340	6	0	4	4.6	COc1ncccc1[C@@H](C)c1c(CCN(C)C)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		45272890	195901	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	409	7	0	5	3.7	CN(C)CCN(C)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1	10.1016/j.bmcl.2009.05.086
		CHEMBL559061	195901	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	409	7	0	5	3.7	CN(C)CCN(C)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1	10.1016/j.bmcl.2009.05.086
		135398737	958	93	None	-4	89	Rat	8.5	pKi	=	8.5	Binding	In vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamineIn vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamine	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0309811
		38	958	93	None	-4	89	Rat	8.5	pKi	=	8.5	Binding	In vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamineIn vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamine	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0309811
		722	958	93	None	-4	89	Rat	8.5	pKi	=	8.5	Binding	In vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamineIn vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamine	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0309811
		CHEMBL42	958	93	None	-4	89	Rat	8.5	pKi	=	8.5	Binding	In vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamineIn vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamine	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0309811
		DB00363	958	93	None	-4	89	Rat	8.5	pKi	=	8.5	Binding	In vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamineIn vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamine	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0309811
		44266958	97241	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.	ChEMBL	382	1	1	3	3.8	CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cc(CO)cnc32)CC1	10.1016/S0960-894X(00)80290-5
		CHEMBL268695	97241	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.	ChEMBL	382	1	1	3	3.8	CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cc(CO)cnc32)CC1	10.1016/S0960-894X(00)80290-5
		11485192	203123	0	None	-	1	Guinea pig	7.7	pKi	=	7.7	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	323	4	1	3	3.7	CN(C)CC/C=C1/c2ccccc2COc2ccc(C(=O)O)cc21	10.1021/jm00089a020
		CHEMBL64067	203123	0	None	-	1	Guinea pig	7.7	pKi	=	7.7	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	323	4	1	3	3.7	CN(C)CC/C=C1/c2ccccc2COc2ccc(C(=O)O)cc21	10.1021/jm00089a020
		2389	3331	118	None	-46	67	Human	7.7	pKi	=	7.7	Binding	Binding affinity to H1 histamine receptor (unknown origin)Binding affinity to H1 histamine receptor (unknown origin)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2020.127681
		5073	3331	118	None	-46	67	Human	7.7	pKi	=	7.7	Binding	Binding affinity to H1 histamine receptor (unknown origin)Binding affinity to H1 histamine receptor (unknown origin)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2020.127681
		96	3331	118	None	-46	67	Human	7.7	pKi	=	7.7	Binding	Binding affinity to H1 histamine receptor (unknown origin)Binding affinity to H1 histamine receptor (unknown origin)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2020.127681
		CHEMBL85	3331	118	None	-46	67	Human	7.7	pKi	=	7.7	Binding	Binding affinity to H1 histamine receptor (unknown origin)Binding affinity to H1 histamine receptor (unknown origin)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2020.127681
		DB00734	3331	118	None	-46	67	Human	7.7	pKi	=	7.7	Binding	Binding affinity to H1 histamine receptor (unknown origin)Binding affinity to H1 histamine receptor (unknown origin)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2020.127681
		9419	35922	35	None	125	6	Human	7.7	pKi	=	7.7	Binding	Binding affinity to H1 receptor (unknown origin)Binding affinity to H1 receptor (unknown origin)	ChEMBL	295	3	0	3	3.0	CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21	10.1016/j.bmcl.2020.127493
		CHEMBL1442422	35922	35	None	125	6	Human	7.7	pKi	=	7.7	Binding	Binding affinity to H1 receptor (unknown origin)Binding affinity to H1 receptor (unknown origin)	ChEMBL	295	3	0	3	3.0	CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21	10.1016/j.bmcl.2020.127493
		71450058	82574	0	None	37	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	453	6	1	3	5.6	O=C(O)Cc1ccc2c(c1)/C(=C/CN1CCCC(Cc3ccccc3)C1)c1ccccc1CO2	10.1021/jm300682j
		CHEMBL2178582	82574	0	None	37	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	453	6	1	3	5.6	O=C(O)Cc1ccc2c(c1)/C(=C/CN1CCCC(Cc3ccccc3)C1)c1ccccc1CO2	10.1021/jm300682j
		1224	1432	83	None	-2	13	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		3100	1432	83	None	-2	13	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		8980	1432	83	None	-2	13	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		916	1432	83	None	-2	13	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		CHEMBL657	1432	83	None	-2	13	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		DB01075	1432	83	None	-2	13	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		1605	2342	117	None	-2	4	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
		3957	2342	117	None	-2	4	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
		7216	2342	117	None	-2	4	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
		CHEMBL998	2342	117	None	-2	4	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
		DB00455	2342	117	None	-2	4	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
		9863340	162027	0	None	-5	4	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptorDisplacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptor	ChEMBL	352	4	0	4	4.0	Cn1c(=O)sc2cc(CCN3CCC(c4ccccc4)CC3)ccc21	10.1016/s0960-894x(02)00123-3
		CHEMBL415985	162027	0	None	-5	4	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptorDisplacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptor	ChEMBL	352	4	0	4	4.0	Cn1c(=O)sc2cc(CCN3CCC(c4ccccc4)CC3)ccc21	10.1016/s0960-894x(02)00123-3
		45485473	197335	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation counting	ChEMBL	457	9	1	4	5.4	COC(=O)c1ccc(CCCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1	10.1016/j.bmcl.2009.07.047
		CHEMBL568892	197335	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation counting	ChEMBL	457	9	1	4	5.4	COC(=O)c1ccc(CCCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1	10.1016/j.bmcl.2009.07.047
		44404954	135265	0	None	-1	3	Human	7.7	pKi	=	7.7	Binding	Inhibition constant against histamine H1 receptorInhibition constant against histamine H1 receptor	ChEMBL	453	6	1	3	5.6	O=C(O)Cc1ccc2c(c1)/C(=C\CN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2	10.1021/jm058225d
		CHEMBL372588	135265	0	None	-1	3	Human	7.7	pKi	=	7.7	Binding	Inhibition constant against histamine H1 receptorInhibition constant against histamine H1 receptor	ChEMBL	453	6	1	3	5.6	O=C(O)Cc1ccc2c(c1)/C(=C\CN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2	10.1021/jm058225d
		9937936	23115	0	None	-	1	Guinea pig	7.7	pKi	=	7.7	Binding	Inhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptorInhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptor	ChEMBL	453	6	1	3	5.6	O=C(O)Cc1ccc2c(c1)/C(=C/CN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2	10.1021/jm00055a013
		CHEMBL133080	23115	0	None	-	1	Guinea pig	7.7	pKi	=	7.7	Binding	Inhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptorInhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptor	ChEMBL	453	6	1	3	5.6	O=C(O)Cc1ccc2c(c1)/C(=C/CN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2	10.1021/jm00055a013
		10049865	24748	0	None	-	1	Guinea pig	7.7	pKi	=	7.7	Binding	Inhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptorInhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptor	ChEMBL	459	6	1	4	6.0	O=C(O)c1ccc2c(c1)C(SCCN1CCC(c3ccccc3)CC1)c1ccccc1CO2	10.1021/jm00055a013
		CHEMBL134424	24748	0	None	-	1	Guinea pig	7.7	pKi	=	7.7	Binding	Inhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptorInhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptor	ChEMBL	459	6	1	4	6.0	O=C(O)c1ccc2c(c1)C(SCCN1CCC(c3ccccc3)CC1)c1ccccc1CO2	10.1021/jm00055a013
		44326405	111585	0	None	6	3	Human	7.7	pKi	=	7.7	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	309	2	0	3	3.8	CN(C)CC1C[C@@H]2c3ccccc3COc3ccccc3[C@H]2O1	10.1016/j.bmcl.2004.03.069
		CHEMBL328209	111585	0	None	6	3	Human	7.7	pKi	=	7.7	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	309	2	0	3	3.8	CN(C)CC1C[C@@H]2c3ccccc3COc3ccccc3[C@H]2O1	10.1016/j.bmcl.2004.03.069
		71212556	143562	0	None	-7	6	Human	7.7	pKi	=	7.7	Binding	Scintillation Proximity Assay: [3H]-Pyrilamine binding experiments are carried out in SPA (scintillation proximity assay) 96-well format. Membranes used in this assay are prepared from HEK-293 cells stably expressing recombinant H1 receptor (human). The incubation is initiated by the addition of a mixture of WGA PVT SPA beads (1 mg/well, Perkin Elmer (MA, USA) RPNQ0001) and 3 μg membranes to assay buffer (67 mM Tris; pH 7.6) containing 3.5 nM [3H]-Pyrilamine and varying concentrations of the test compound (10 point concentration response curves). Non-specific binding is determined in the presence of 10 μM Triprolidine. Samples are incubated for 4 hr. at room temperature (22° C.) and then read in a Microbeta Trilux.Scintillation Proximity Assay: [3H]-Pyrilamine binding experiments are carried out in SPA (scintillation proximity assay) 96-well format. Membranes used in this assay are prepared from HEK-293 cells stably expressing recombinant H1 receptor (human). The incubation is initiated by the addition of a mixture of WGA PVT SPA beads (1 mg/well, Perkin Elmer (MA, USA) RPNQ0001) and 3 μg membranes to assay buffer (67 mM Tris; pH 7.6) containing 3.5 nM [3H]-Pyrilamine and varying concentrations of the test compound (10 point concentration response curves). Non-specific binding is determined in the presence of 10 μM Triprolidine. Samples are incubated for 4 hr. at room temperature (22° C.) and then read in a Microbeta Trilux.	ChEMBL	433	3	1	6	4.6	Cc1ccc2c(c1)Oc1sc(Cl)cc1C(N1CCN(CC(C)(C)C(=O)O)CC1)=N2	nan
		CHEMBL3899169	143562	0	None	-7	6	Human	7.7	pKi	=	7.7	Binding	Scintillation Proximity Assay: [3H]-Pyrilamine binding experiments are carried out in SPA (scintillation proximity assay) 96-well format. Membranes used in this assay are prepared from HEK-293 cells stably expressing recombinant H1 receptor (human). The incubation is initiated by the addition of a mixture of WGA PVT SPA beads (1 mg/well, Perkin Elmer (MA, USA) RPNQ0001) and 3 μg membranes to assay buffer (67 mM Tris; pH 7.6) containing 3.5 nM [3H]-Pyrilamine and varying concentrations of the test compound (10 point concentration response curves). Non-specific binding is determined in the presence of 10 μM Triprolidine. Samples are incubated for 4 hr. at room temperature (22° C.) and then read in a Microbeta Trilux.Scintillation Proximity Assay: [3H]-Pyrilamine binding experiments are carried out in SPA (scintillation proximity assay) 96-well format. Membranes used in this assay are prepared from HEK-293 cells stably expressing recombinant H1 receptor (human). The incubation is initiated by the addition of a mixture of WGA PVT SPA beads (1 mg/well, Perkin Elmer (MA, USA) RPNQ0001) and 3 μg membranes to assay buffer (67 mM Tris; pH 7.6) containing 3.5 nM [3H]-Pyrilamine and varying concentrations of the test compound (10 point concentration response curves). Non-specific binding is determined in the presence of 10 μM Triprolidine. Samples are incubated for 4 hr. at room temperature (22° C.) and then read in a Microbeta Trilux.	ChEMBL	433	3	1	6	4.6	Cc1ccc2c(c1)Oc1sc(Cl)cc1C(N1CCN(CC(C)(C)C(=O)O)CC1)=N2	nan
		524022	31644	1	None	-	1	Rat	5.7	pKi	=	5.7	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	318	0	0	2	3.6	CC(=O)N1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1021/jm00105a069
		CHEMBL140483	31644	1	None	-	1	Rat	5.7	pKi	=	5.7	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	318	0	0	2	3.6	CC(=O)N1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1021/jm00105a069
		71452695	78683	0	None	-5011	3	Human	4.7	pKi	=	4.7	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	453	10	1	6	3.0	N#Cc1ccc(S(=O)(=O)N[C@H]2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)C2)cc1	10.1016/s0960-894x(02)00685-6
		CHEMBL2112451	78683	0	None	-5011	3	Human	4.7	pKi	=	4.7	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	453	10	1	6	3.0	N#Cc1ccc(S(=O)(=O)N[C@H]2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)C2)cc1	10.1016/s0960-894x(02)00685-6
		44270248	47973	0	None	-	1	Rat	4.7	pKi	=	4.7	Binding	Displacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptorDisplacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptor	ChEMBL	305	3	1	5	1.8	C[C@H]1CN(CCc2ccc3c(c2)sc(=O)n3C)C[C@@H](C)N1	10.1016/s0960-894x(02)00123-3
		CHEMBL15499	47973	0	None	-	1	Rat	4.7	pKi	=	4.7	Binding	Displacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptorDisplacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptor	ChEMBL	305	3	1	5	1.8	C[C@H]1CN(CCc2ccc3c(c2)sc(=O)n3C)C[C@@H](C)N1	10.1016/s0960-894x(02)00123-3
		10156707	202642	0	None	-6	2	Rat	6.7	pKi	=	6.7	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	ChEMBL	381	9	3	3	4.6	N=C(CCCc1c[nH]cn1)NCCC(c1ccc(Cl)cc1)c1ccccn1	10.1016/s0960-894x(03)00357-3
		CHEMBL61348	202642	0	None	-6	2	Rat	6.7	pKi	=	6.7	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	ChEMBL	381	9	3	3	4.6	N=C(CCCc1c[nH]cn1)NCCC(c1ccc(Cl)cc1)c1ccccn1	10.1016/s0960-894x(03)00357-3
		10456093	197509	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation counting	ChEMBL	443	9	2	3	5.4	O=C(O)c1ccc(CCCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1	10.1016/j.bmcl.2009.07.047
		CHEMBL570033	197509	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation counting	ChEMBL	443	9	2	3	5.4	O=C(O)c1ccc(CCCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1	10.1016/j.bmcl.2009.07.047
		44304377	202777	0	None	-112	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	424	11	0	6	3.5	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3cnccn3)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL62115	202777	0	None	-112	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	424	11	0	6	3.5	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3cnccn3)CC2)cc1	10.1016/s0960-894x(02)00309-8
		44591134	176200	0	None	-169	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	535	11	0	5	7.7	CN(CCCN1c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
		CHEMBL459373	176200	0	None	-169	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	535	11	0	5	7.7	CN(CCCN1c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
		2712	916	34	None	-5	4	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	299	1	1	3	3.0	CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl	nan
		3370	916	34	None	-5	4	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	299	1	1	3	3.0	CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl	nan
		594	916	34	None	-5	4	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	299	1	1	3	3.0	CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl	nan
		CHEMBL451	916	34	None	-5	4	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	299	1	1	3	3.0	CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl	nan
		DB00475	916	34	None	-5	4	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	299	1	1	3	3.0	CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl	nan
		44304309	169216	0	None	-3	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	414	8	0	5	3.6	CCOC(=O)N1CCN(CCCOc2ccc(C(=O)c3ccc(F)cc3)cc2)CC1	10.1016/s0960-894x(02)00309-8
		CHEMBL440864	169216	0	None	-3	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	414	8	0	5	3.6	CCOC(=O)N1CCN(CCCOc2ccc(C(=O)c3ccc(F)cc3)cc2)CC1	10.1016/s0960-894x(02)00309-8
		44304211	102197	0	None	-6918	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	373	9	1	5	1.9	CC[C@@H](N)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		CHEMBL302829	102197	0	None	-6918	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	373	9	1	5	1.9	CC[C@@H](N)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		127035835	137285	0	None	-1	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	385	4	1	5	3.6	CN1CCN(c2nc(NCc3ccccc3)nc3c2CCc2ccccc2-3)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL3752270	137285	0	None	-1	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	385	4	1	5	3.6	CN1CCN(c2nc(NCc3ccccc3)nc3c2CCc2ccccc2-3)CC1	10.1016/j.bmcl.2015.12.035
		71519674	89729	0	None	-2454	5	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H1 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H1 receptor expressed in HEK cells	ChEMBL	270	3	2	6	0.9	CNC1CN(c2nc(N)nc3cc(C4CC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376804	89729	0	None	-2454	5	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]histamine from human histamine H1 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H1 receptor expressed in HEK cells	ChEMBL	270	3	2	6	0.9	CNC1CN(c2nc(N)nc3cc(C4CC4)cnc23)C1	10.1016/j.bmcl.2013.02.091
		14554138	110662	37	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	338	1	0	2	3.9	O=CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/jm00105a069
		CHEMBL325909	110662	37	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	338	1	0	2	3.9	O=CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/jm00105a069
		2337	3256	77	None	1	62	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human H1 receptorBinding affinity towards human H1 receptor	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm0002432
		50	3256	77	None	1	62	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human H1 receptorBinding affinity towards human H1 receptor	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm0002432
		5002	3256	77	None	1	62	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human H1 receptorBinding affinity towards human H1 receptor	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm0002432
		CHEMBL716	3256	77	None	1	62	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human H1 receptorBinding affinity towards human H1 receptor	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm0002432
		DB01224	3256	77	None	1	62	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human H1 receptorBinding affinity towards human H1 receptor	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm0002432
		57334707	90476	0	None	-4	5	Guinea pig	7.7	pKi	=	7.7	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysisDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysis	ChEMBL	464	7	0	6	5.7	Cc1cc(=O)oc2c(C)c(OCCCCN3CCC(c4noc5cc(F)ccc45)CC3)ccc12	10.1021/jm400408r
		CHEMBL2387230	90476	0	None	-4	5	Guinea pig	7.7	pKi	=	7.7	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysisDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysis	ChEMBL	464	7	0	6	5.7	Cc1cc(=O)oc2c(C)c(OCCCCN3CCC(c4noc5cc(F)ccc45)CC3)ccc12	10.1021/jm400408r
		56966478	105468	0	None	1	4	Guinea pig	7.7	pKi	=	7.7	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenate after 60 mins by liquid scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenate after 60 mins by liquid scintillation counting	ChEMBL	476	7	0	6	5.6	O=c1oc2cc(OCCCCN3CCC(c4noc5cc(F)ccc45)CC3)ccc2c2c1CCC2	10.1016/j.ejmech.2014.01.012
		CHEMBL3120688	105468	0	None	1	4	Guinea pig	7.7	pKi	=	7.7	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenate after 60 mins by liquid scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenate after 60 mins by liquid scintillation counting	ChEMBL	476	7	0	6	5.6	O=c1oc2cc(OCCCCN3CCC(c4noc5cc(F)ccc45)CC3)ccc2c2c1CCC2	10.1016/j.ejmech.2014.01.012
		9844271	130682	1	None	-1	5	Rat	7.7	pKi	=	7.7	Binding	Half-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenateHalf-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN([C@@H]2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		CHEMBL368324	130682	1	None	-1	5	Rat	7.7	pKi	=	7.7	Binding	Half-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenateHalf-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN([C@@H]2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		9844271	130682	1	None	-1	5	Rat	7.7	pKi	=	7.7	Binding	In vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamineIn vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamine	ChEMBL	333	1	0	4	3.6	CN1CCN([C@@H]2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm0309811
		CHEMBL368324	130682	1	None	-1	5	Rat	7.7	pKi	=	7.7	Binding	In vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamineIn vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamine	ChEMBL	333	1	0	4	3.6	CN1CCN([C@@H]2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm0309811
		2389	3331	118	None	-52	67	Guinea pig	7.7	pKi	=	7.7	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysisDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysis	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm400408r
		5073	3331	118	None	-52	67	Guinea pig	7.7	pKi	=	7.7	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysisDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysis	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm400408r
		96	3331	118	None	-52	67	Guinea pig	7.7	pKi	=	7.7	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysisDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysis	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm400408r
		CHEMBL85	3331	118	None	-52	67	Guinea pig	7.7	pKi	=	7.7	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysisDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysis	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm400408r
		DB00734	3331	118	None	-52	67	Guinea pig	7.7	pKi	=	7.7	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysisDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysis	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm400408r
		44267047	9405	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.	ChEMBL	398	1	0	3	5.0	CSc1cnc2c(c1)CCc1cc(Cl)ccc1C2=C1CCN(C(C)=O)CC1	10.1016/S0960-894X(00)80290-5
		CHEMBL11158	9405	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.	ChEMBL	398	1	0	3	5.0	CSc1cnc2c(c1)CCc1cc(Cl)ccc1C2=C1CCN(C(C)=O)CC1	10.1016/S0960-894X(00)80290-5
		1353	1911	93	None	-602	83	Rat	5.7	pKi	=	5.7	Binding	Compound was tested for the binding affinity against rat cortical H1 receptor by Radio ligand [3H]pyrilamine binding assay.Compound was tested for the binding affinity against rat cortical H1 receptor by Radio ligand [3H]pyrilamine binding assay.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
		3559	1911	93	None	-602	83	Rat	5.7	pKi	=	5.7	Binding	Compound was tested for the binding affinity against rat cortical H1 receptor by Radio ligand [3H]pyrilamine binding assay.Compound was tested for the binding affinity against rat cortical H1 receptor by Radio ligand [3H]pyrilamine binding assay.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
		86	1911	93	None	-602	83	Rat	5.7	pKi	=	5.7	Binding	Compound was tested for the binding affinity against rat cortical H1 receptor by Radio ligand [3H]pyrilamine binding assay.Compound was tested for the binding affinity against rat cortical H1 receptor by Radio ligand [3H]pyrilamine binding assay.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
		CHEMBL54	1911	93	None	-602	83	Rat	5.7	pKi	=	5.7	Binding	Compound was tested for the binding affinity against rat cortical H1 receptor by Radio ligand [3H]pyrilamine binding assay.Compound was tested for the binding affinity against rat cortical H1 receptor by Radio ligand [3H]pyrilamine binding assay.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
		DB00502	1911	93	None	-602	83	Rat	5.7	pKi	=	5.7	Binding	Compound was tested for the binding affinity against rat cortical H1 receptor by Radio ligand [3H]pyrilamine binding assay.Compound was tested for the binding affinity against rat cortical H1 receptor by Radio ligand [3H]pyrilamine binding assay.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
		57401706	70171	0	None	-37	11	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]pyrilamine from human H1 receptor by liquid scintillation countingDisplacement of [3H]pyrilamine from human H1 receptor by liquid scintillation counting	ChEMBL	331	6	0	4	3.5	Fc1ccc(SCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2011.12.019
		CHEMBL1940419	70171	0	None	-37	11	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]pyrilamine from human H1 receptor by liquid scintillation countingDisplacement of [3H]pyrilamine from human H1 receptor by liquid scintillation counting	ChEMBL	331	6	0	4	3.5	Fc1ccc(SCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2011.12.019
		57398985	67883	0	None	-16	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	569	12	2	7	4.4	COc1ccc(CN(CCN(C)CC(C)Nc2ccc3[nH]c(C(=O)N4CCN(C)CC4)cc3c2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		CHEMBL1910385	67883	0	None	-16	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	569	12	2	7	4.4	COc1ccc(CN(CCN(C)CC(C)Nc2ccc3[nH]c(C(=O)N4CCN(C)CC4)cc3c2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		168268680	192766	0	None	-1	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	662	11	8	8	4.8	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5172675	192766	0	None	-1	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	662	11	8	8	4.8	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221210	192766	0	None	-1	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	662	11	8	8	4.8	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1	10.1021/acs.jmedchem.1c00692
		44304437	100996	0	None	-371	3	Human	4.7	pKi	=	4.7	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	404	11	1	5	3.1	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)C(C)(C)O)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL294349	100996	0	None	-371	3	Human	4.7	pKi	=	4.7	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	404	11	1	5	3.1	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)C(C)(C)O)CC2)cc1	10.1016/s0960-894x(02)00309-8
		44304393	105957	0	None	-218	3	Human	4.7	pKi	=	4.7	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	517	13	1	6	4.9	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)CC2)cc1	10.1016/s0960-894x(02)00310-4
		CHEMBL312958	105957	0	None	-218	3	Human	4.7	pKi	=	4.7	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	517	13	1	6	4.9	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)CC2)cc1	10.1016/s0960-894x(02)00310-4
		164622330	185862	0	None	-870	6	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	360	6	4	4	2.3	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)N[C@@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4867962	185862	0	None	-870	6	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	360	6	4	4	2.3	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)N[C@@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4531334	213985	31	None	-	1	Human	5.7	pKi	=	5.7	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000321b HRH1Selectivity interaction (GPCR panel (PDSP screen)) EUB0000321b HRH1	ChEMBL		None	None	None		CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5ccncc5)ccc4n3)cc2)CC1	10.6019/CHEMBL5212743
		127051845	140729	0	None	-12	9	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	309	6	0	3	3.7	COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3817898	140729	0	None	-12	9	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	309	6	0	3	3.7	COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		10066369	120258	0	None	-8	6	Human	6.7	pKi	=	6.7	Binding	Compound was evaluated for binding affinity towards cloned human histamine H1 receptors stably expressed in CHO-K1 cells using [3H]mepyramineCompound was evaluated for binding affinity towards cloned human histamine H1 receptors stably expressed in CHO-K1 cells using [3H]mepyramine	ChEMBL	348	7	0	2	5.7	CC(C1=C(CCN(C(C)C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL352375	120258	0	None	-8	6	Human	6.7	pKi	=	6.7	Binding	Compound was evaluated for binding affinity towards cloned human histamine H1 receptors stably expressed in CHO-K1 cells using [3H]mepyramineCompound was evaluated for binding affinity towards cloned human histamine H1 receptors stably expressed in CHO-K1 cells using [3H]mepyramine	ChEMBL	348	7	0	2	5.7	CC(C1=C(CCN(C(C)C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		44304516	165356	0	None	-512	3	Human	4.7	pKi	=	4.7	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	357	8	1	5	1.5	O=C1C[C@H](N2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)CC2)N1	10.1016/s0960-894x(02)00310-4
		CHEMBL423666	165356	0	None	-512	3	Human	4.7	pKi	=	4.7	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	357	8	1	5	1.5	O=C1C[C@H](N2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)CC2)N1	10.1016/s0960-894x(02)00310-4
		44304013	202894	0	None	-416	3	Human	4.7	pKi	=	4.7	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	401	8	1	5	2.6	CC(C)(C)[C@@H](N)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		CHEMBL62716	202894	0	None	-416	3	Human	4.7	pKi	=	4.7	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	401	8	1	5	2.6	CC(C)(C)[C@@H](N)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		164621681	185580	0	None	-173	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	444	7	4	5	3.2	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccc(OC(F)(F)F)cc1	10.1016/j.ejmech.2021.113190
		CHEMBL4863523	185580	0	None	-173	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	444	7	4	5	3.2	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccc(OC(F)(F)F)cc1	10.1016/j.ejmech.2021.113190
		11230971	123065	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity for H1 histamine receptor expressed in CHO cellsBinding affinity for H1 histamine receptor expressed in CHO cells	ChEMBL	268	0	1	4	2.0	Cn1ccc2c1CCn1ccnc1C2=C1CCNCC1	10.1021/jm049495j
		CHEMBL360953	123065	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity for H1 histamine receptor expressed in CHO cellsBinding affinity for H1 histamine receptor expressed in CHO cells	ChEMBL	268	0	1	4	2.0	Cn1ccc2c1CCn1ccnc1C2=C1CCNCC1	10.1021/jm049495j
		135446209	9585	58	None	-2	3	Human	7.7	pKi	=	7.7	Binding	In vitro binding affinity of compound against histamine H1 neuronal receptorIn vitro binding affinity of compound against histamine H1 neuronal receptor	ChEMBL	298	0	2	5	3.1	Cc1cc2c(s1)Nc1ccccc1N=C2N1CCNCC1	10.1016/S0960-894X(96)00567-7
		CHEMBL1125	9585	58	None	-2	3	Human	7.7	pKi	=	7.7	Binding	In vitro binding affinity of compound against histamine H1 neuronal receptorIn vitro binding affinity of compound against histamine H1 neuronal receptor	ChEMBL	298	0	2	5	3.1	Cc1cc2c(s1)Nc1ccccc1N=C2N1CCNCC1	10.1016/S0960-894X(96)00567-7
		2389	3331	118	None	-52	67	Guinea pig	7.6	pKi	=	7.6	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenate after 60 mins by liquid scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenate after 60 mins by liquid scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2014.01.012
		5073	3331	118	None	-52	67	Guinea pig	7.6	pKi	=	7.6	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenate after 60 mins by liquid scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenate after 60 mins by liquid scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2014.01.012
		96	3331	118	None	-52	67	Guinea pig	7.6	pKi	=	7.6	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenate after 60 mins by liquid scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenate after 60 mins by liquid scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2014.01.012
		CHEMBL85	3331	118	None	-52	67	Guinea pig	7.6	pKi	=	7.6	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenate after 60 mins by liquid scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenate after 60 mins by liquid scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2014.01.012
		DB00734	3331	118	None	-52	67	Guinea pig	7.6	pKi	=	7.6	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenate after 60 mins by liquid scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenate after 60 mins by liquid scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2014.01.012
		90469115	185842	4	None	-72	17	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	410	3	1	6	3.0	O=S(=O)(c1cccc(F)c1)n1ccc2c(N3CCNCC3)nc3ccccc3c21	10.1021/acs.jmedchem.1c00224
		CHEMBL4867565	185842	4	None	-72	17	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	410	3	1	6	3.0	O=S(=O)(c1cccc(F)c1)n1ccc2c(N3CCNCC3)nc3ccccc3c21	10.1021/acs.jmedchem.1c00224
		10575070	67881	0	None	79	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	439	7	1	3	4.7	O=C(c1cc2ccccc2[nH]1)N1CCN(CCOC(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2011.09.001
		CHEMBL1910383	67881	0	None	79	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	439	7	1	3	4.7	O=C(c1cc2ccccc2[nH]1)N1CCN(CCOC(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2011.09.001
		44304387	202928	0	None	-446	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	334	7	0	5	2.4	CCOC(=O)N1CCN(CCCOc2ccc(C(C)=O)cc2)CC1	10.1016/s0960-894x(02)00309-8
		CHEMBL62840	202928	0	None	-446	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	334	7	0	5	2.4	CCOC(=O)N1CCN(CCCOc2ccc(C(C)=O)cc2)CC1	10.1016/s0960-894x(02)00309-8
		44304244	203176	0	None	-141	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	372	12	0	4	4.2	CCCCCC(=O)c1ccc(OCCCN2CCN(CC3CC3)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL64253	203176	0	None	-141	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	372	12	0	4	4.2	CCCCCC(=O)c1ccc(OCCCN2CCN(CC3CC3)CC2)cc1	10.1016/s0960-894x(02)00309-8
		90654503	110312	0	None	-29	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	483	9	1	4	4.9	O=C1NC(c2ccccc2)(c2ccccc2)C(=O)N1Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.ejmech.2014.03.014
		CHEMBL3238447	110312	0	None	-29	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	483	9	1	4	4.9	O=C1NC(c2ccccc2)(c2ccccc2)C(=O)N1Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.ejmech.2014.03.014
		44304741	202917	0	None	-223	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	466	13	1	6	3.3	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@@H](N)Cc3ccncc3)CC2)cc1	10.1016/s0960-894x(02)00310-4
		CHEMBL62808	202917	0	None	-223	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	466	13	1	6	3.3	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@@H](N)Cc3ccncc3)CC2)cc1	10.1016/s0960-894x(02)00310-4
		57402933	69026	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	260	4	2	3	2.1	CNCC(O)CN1c2ccccc2C2CCCCC21	10.1021/jm2011589
		CHEMBL1923528	69026	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	260	4	2	3	2.1	CNCC(O)CN1c2ccccc2C2CCCCC21	10.1021/jm2011589
		155537890	172341	0	None	8	2	Guinea pig	7.6	pKi	=	7.6	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysisDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysis	ChEMBL	302	5	0	3	2.6	CN1CCc2ccc(OCCCN3CCCCC3)cc2C1=O	10.1016/j.bmcl.2019.04.015
		CHEMBL4475658	172341	0	None	8	2	Guinea pig	7.6	pKi	=	7.6	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysisDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysis	ChEMBL	302	5	0	3	2.6	CN1CCc2ccc(OCCCN3CCCCC3)cc2C1=O	10.1016/j.bmcl.2019.04.015
		11154555	800	62	None	-56	12	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-pyrilamine from human H1 histamine receptor expressed in human HEK293 cellsDisplacement of [3H]-pyrilamine from human H1 histamine receptor expressed in human HEK293 cells	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2020.127681
		5037	800	62	None	-56	12	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-pyrilamine from human H1 histamine receptor expressed in human HEK293 cellsDisplacement of [3H]-pyrilamine from human H1 histamine receptor expressed in human HEK293 cells	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2020.127681
		7671	800	62	None	-56	12	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-pyrilamine from human H1 histamine receptor expressed in human HEK293 cellsDisplacement of [3H]-pyrilamine from human H1 histamine receptor expressed in human HEK293 cells	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2020.127681
		CHEMBL2028019	800	62	None	-56	12	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-pyrilamine from human H1 histamine receptor expressed in human HEK293 cellsDisplacement of [3H]-pyrilamine from human H1 histamine receptor expressed in human HEK293 cells	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2020.127681
		CHEMBL3085826	800	62	None	-56	12	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-pyrilamine from human H1 histamine receptor expressed in human HEK293 cellsDisplacement of [3H]-pyrilamine from human H1 histamine receptor expressed in human HEK293 cells	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2020.127681
		DB06016	800	62	None	-56	12	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-pyrilamine from human H1 histamine receptor expressed in human HEK293 cellsDisplacement of [3H]-pyrilamine from human H1 histamine receptor expressed in human HEK293 cells	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2020.127681
		44267053	6462	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.	ChEMBL	428	1	0	2	5.9	CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cc(-c4ccccc4)cnc32)CC1	10.1016/S0960-894X(00)80290-5
		CHEMBL10826	6462	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.	ChEMBL	428	1	0	2	5.9	CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cc(-c4ccccc4)cnc32)CC1	10.1016/S0960-894X(00)80290-5
		44267061	98228	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.	ChEMBL	366	0	0	2	4.6	CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3c(C)ccnc32)CC1	10.1016/S0960-894X(00)80290-5
		CHEMBL274357	98228	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.	ChEMBL	366	0	0	2	4.6	CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3c(C)ccnc32)CC1	10.1016/S0960-894X(00)80290-5
		44334212	4629	0	None	-501	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	456	11	1	5	3.7	CCc1ccc(S(=O)(=O)N[C@H]2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)C2)cc1	10.1016/s0960-894x(02)00685-6
		CHEMBL102925	4629	0	None	-501	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	456	11	1	5	3.7	CCc1ccc(S(=O)(=O)N[C@H]2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)C2)cc1	10.1016/s0960-894x(02)00685-6
		44334369	5014	0	None	-436	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	484	10	1	5	4.4	CC(C)(C)c1ccc(S(=O)(=O)N[C@H]2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)C2)cc1	10.1016/s0960-894x(02)00685-6
		CHEMBL105071	5014	0	None	-436	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	484	10	1	5	4.4	CC(C)(C)c1ccc(S(=O)(=O)N[C@H]2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)C2)cc1	10.1016/s0960-894x(02)00685-6
		44275807	98970	0	None	-2137	10	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards human histaminergic (H1) receptorBinding affinity towards human histaminergic (H1) receptor	ChEMBL	422	7	0	4	4.5	C[C@H]1CC[C@H](C)N1CCCOc1ccc(-c2ccc(C(=O)N3CCOCC3)cc2)cc1	10.1016/s0960-894x(03)00118-5
		CHEMBL27979	98970	0	None	-2137	10	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards human histaminergic (H1) receptorBinding affinity towards human histaminergic (H1) receptor	ChEMBL	422	7	0	4	4.5	C[C@H]1CC[C@H](C)N1CCCOc1ccc(-c2ccc(C(=O)N3CCOCC3)cc2)cc1	10.1016/s0960-894x(03)00118-5
		164608815	184454	0	None	-58	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	380	7	4	4	2.8	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)C1CCCCC1	10.1016/j.ejmech.2021.113190
		CHEMBL4846638	184454	0	None	-58	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	380	7	4	4	2.8	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)C1CCCCC1	10.1016/j.ejmech.2021.113190
		53359025	62353	0	None	-25	5	Human	5.6	pKi	=	5.6	Binding	Binding affinity to Histamine H1 receptorBinding affinity to Histamine H1 receptor	ChEMBL	339	5	1	3	2.5	O=C(CCCN1C2C3C4CC5C6C4C2C6C1(O)C53)c1ccc(F)cc1	10.1016/j.bmcl.2012.08.046
		CHEMBL1779058	62353	0	None	-25	5	Human	5.6	pKi	=	5.6	Binding	Binding affinity to Histamine H1 receptorBinding affinity to Histamine H1 receptor	ChEMBL	339	5	1	3	2.5	O=C(CCCN1C2C3C4CC5C6C4C2C6C1(O)C53)c1ccc(F)cc1	10.1016/j.bmcl.2012.08.046
		53324553	56855	0	None	-3	10	Human	5.6	pKi	=	5.6	Binding	Inhibition of H1 receptorInhibition of H1 receptor	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmcl.2010.11.075
		CHEMBL1643900	56855	0	None	-3	10	Human	5.6	pKi	=	5.6	Binding	Inhibition of H1 receptorInhibition of H1 receptor	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmcl.2010.11.075
		53324553	56855	0	None	-3	10	Human	5.6	pKi	=	5.6	Binding	Inhibition of histamine H1 receptor (unknown origin) by PDSP assayInhibition of histamine H1 receptor (unknown origin) by PDSP assay	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmc.2013.07.045
		CHEMBL1643900	56855	0	None	-3	10	Human	5.6	pKi	=	5.6	Binding	Inhibition of histamine H1 receptor (unknown origin) by PDSP assayInhibition of histamine H1 receptor (unknown origin) by PDSP assay	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmc.2013.07.045
		1204	1932	119	None	-501	24	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.1c00692
		1247	1932	119	None	-501	24	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.1c00692
		1375	1932	119	None	-501	24	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.1c00692
		774	1932	119	None	-501	24	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.1c00692
		CHEMBL90	1932	119	None	-501	24	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.1c00692
		DB05381	1932	119	None	-501	24	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.1c00692
		1204	1932	119	None	-501	24	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.ejmech.2021.113190
		1247	1932	119	None	-501	24	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.ejmech.2021.113190
		1375	1932	119	None	-501	24	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.ejmech.2021.113190
		774	1932	119	None	-501	24	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.ejmech.2021.113190
		CHEMBL90	1932	119	None	-501	24	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.ejmech.2021.113190
		DB05381	1932	119	None	-501	24	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1016/j.ejmech.2021.113190
		168269877	190027	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	783	22	6	8	3.0	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5171683	190027	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	783	22	6	8	3.0	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		164622259	185730	0	None	-2290	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	336	6	4	5	1.4	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCc1ccco1	10.1016/j.ejmech.2021.113190
		CHEMBL4865965	185730	0	None	-2290	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	336	6	4	5	1.4	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCc1ccco1	10.1016/j.ejmech.2021.113190
		168269877	190027	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	783	22	6	8	3.0	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5171683	190027	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	783	22	6	8	3.0	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		15749417	102097	0	None	-	1	Guinea pig	7.6	pKi	=	7.6	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	323	4	1	3	3.7	CN(C)CC/C=C1/c2ccccc2COc2cc(C(=O)O)ccc21	10.1021/jm00089a020
		CHEMBL302215	102097	0	None	-	1	Guinea pig	7.6	pKi	=	7.6	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	323	4	1	3	3.7	CN(C)CC/C=C1/c2ccccc2COc2cc(C(=O)O)ccc21	10.1021/jm00089a020
		53321494	57749	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	311	7	0	3	3.3	CN(CCF)CCC1=C(Cc2cnccn2)c2ccccc2C1	10.1016/j.bmcl.2010.12.053
		CHEMBL1669407	57749	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	311	7	0	3	3.3	CN(CCF)CCC1=C(Cc2cnccn2)c2ccccc2C1	10.1016/j.bmcl.2010.12.053
		53318874	57769	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	371	7	0	5	3.9	C[C@H](C1=C(CCN(C)Cc2cnccn2)Cc2ccccc21)c1cnccn1	10.1016/j.bmcl.2010.12.053
		CHEMBL1669426	57769	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	371	7	0	5	3.9	C[C@H](C1=C(CCN(C)Cc2cnccn2)Cc2ccccc21)c1cnccn1	10.1016/j.bmcl.2010.12.053
		18715382	8955	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.	ChEMBL	386	0	0	2	4.9	CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3c(Cl)ccnc32)CC1	10.1016/S0960-894X(00)80290-5
		CHEMBL10981	8955	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.	ChEMBL	386	0	0	2	4.9	CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3c(Cl)ccnc32)CC1	10.1016/S0960-894X(00)80290-5
		46216770	199269	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]Pyrilamine from human cloned histamine H1 receptorDisplacement of [3H]Pyrilamine from human cloned histamine H1 receptor	ChEMBL	313	5	1	1	4.6	c1ccc(CCNCC2c3ccccc3Cc3ccccc32)cc1	10.1016/j.bmcl.2009.12.064
		CHEMBL590241	199269	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]Pyrilamine from human cloned histamine H1 receptorDisplacement of [3H]Pyrilamine from human cloned histamine H1 receptor	ChEMBL	313	5	1	1	4.6	c1ccc(CCNCC2c3ccccc3Cc3ccccc32)cc1	10.1016/j.bmcl.2009.12.064
		10066369	120258	0	None	-8	6	Human	5.6	pKi	=	5.6	Binding	Compound was evaluated for binding affinity towards cloned human histamine H1 receptors stably expressed in CHO-K1 cells using [3H]mepyramineCompound was evaluated for binding affinity towards cloned human histamine H1 receptors stably expressed in CHO-K1 cells using [3H]mepyramine	ChEMBL	348	7	0	2	5.7	CC(C1=C(CCN(C(C)C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL352375	120258	0	None	-8	6	Human	5.6	pKi	=	5.6	Binding	Compound was evaluated for binding affinity towards cloned human histamine H1 receptors stably expressed in CHO-K1 cells using [3H]mepyramineCompound was evaluated for binding affinity towards cloned human histamine H1 receptors stably expressed in CHO-K1 cells using [3H]mepyramine	ChEMBL	348	7	0	2	5.7	CC(C1=C(CCN(C(C)C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		164614841	185274	0	None	-691	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	388	7	4	4	3.0	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(c1ccccc1)C(C)C	10.1016/j.ejmech.2021.113190
		CHEMBL4858849	185274	0	None	-691	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	388	7	4	4	3.0	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(c1ccccc1)C(C)C	10.1016/j.ejmech.2021.113190
		164628701	186467	0	None	-144	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	338	5	4	4	1.9	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC1CCCCC1	10.1016/j.ejmech.2021.113190
		CHEMBL4876743	186467	0	None	-144	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	338	5	4	4	1.9	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC1CCCCC1	10.1016/j.ejmech.2021.113190
		72152558	162404	5	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	331	5	1	5	2.7	Cc1cccc(N2CCN(CCNc3cncc(Cl)n3)CC2)c1	10.1021/acs.jmedchem.8b00718
		CHEMBL4165881	162404	5	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	331	5	1	5	2.7	Cc1cccc(N2CCN(CCNc3cncc(Cl)n3)CC2)c1	10.1021/acs.jmedchem.8b00718
		657255	199084	34	None	-18	15	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	nan
		CHEMBL588119	199084	34	None	-18	15	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	nan
		53317595	57759	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	341	5	0	3	3.8	FC1(F)CCN(CCC2=C(Cc3cnccn3)c3ccccc3C2)C1	10.1016/j.bmcl.2010.12.053
		CHEMBL1669416	57759	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	341	5	0	3	3.8	FC1(F)CCN(CCC2=C(Cc3cnccn3)c3ccccc3C2)C1	10.1016/j.bmcl.2010.12.053
		60785	205893	48	None	-204	7	Guinea pig	7.6	pKi	=	7.6	Binding	Binding constant against histamine H1 receptor (in vivo)Binding constant against histamine H1 receptor (in vivo)	ChEMBL	425	5	0	4	3.7	O=S1(=O)c2cccc3cccc(c23)N1CCCN1CCN(c2ccc(F)cc2)CC1	10.1021/jm00112a025
		CHEMBL83894	205893	48	None	-204	7	Guinea pig	7.6	pKi	=	7.6	Binding	Binding constant against histamine H1 receptor (in vivo)Binding constant against histamine H1 receptor (in vivo)	ChEMBL	425	5	0	4	3.7	O=S1(=O)c2cccc3cccc(c23)N1CCCN1CCN(c2ccc(F)cc2)CC1	10.1021/jm00112a025
		14248602	54442	0	None	21	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cellsDisplacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cells	ChEMBL	237	2	0	1	3.3	CN(C)CC1c2ccccc2Cc2ccccc21	10.1016/j.bmc.2009.08.016
		CHEMBL160933	54442	0	None	21	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cellsDisplacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cells	ChEMBL	237	2	0	1	3.3	CN(C)CC1c2ccccc2Cc2ccccc21	10.1016/j.bmc.2009.08.016
		242	470	124	None	-22	51	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-pyrilamine from human histamine H1 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2021.113931
		34	470	124	None	-22	51	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-pyrilamine from human histamine H1 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2021.113931
		60795	470	124	None	-22	51	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-pyrilamine from human histamine H1 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2021.113931
		CHEMBL1112	470	124	None	-22	51	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-pyrilamine from human histamine H1 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2021.113931
		DB01238	470	124	None	-22	51	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-pyrilamine from human histamine H1 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2021.113931
		242	470	124	None	-22	51	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2016.05.053
		34	470	124	None	-22	51	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2016.05.053
		60795	470	124	None	-22	51	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2016.05.053
		CHEMBL1112	470	124	None	-22	51	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2016.05.053
		DB01238	470	124	None	-22	51	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2016.05.053
		71072115	81258	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	515	8	1	5	5.1	N#Cc1cccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158770	81258	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	515	8	1	5	5.1	N#Cc1cccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1	10.1016/j.bmcl.2012.08.103
		69348078	81291	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	476	7	1	4	5.4	O=C(O)[C@H](c1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158820	81291	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	476	7	1	4	5.4	O=C(O)[C@H](c1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		59296048	84016	0	None	-6	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	582	9	4	7	2.4	CNS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1	10.1016/j.bmcl.2012.09.112
		CHEMBL2207284	84016	0	None	-6	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	582	9	4	7	2.4	CNS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1	10.1016/j.bmcl.2012.09.112
		59295914	84084	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	638	9	4	8	2.2	CC1(O)CN(S(=O)(=O)c2ccc3c(C(=O)NC[C@@H](O)CN4CCC(Oc5ccc(Cl)c(Cl)c5)CC4)c[nH]c(=O)c3c2)C1	10.1016/j.bmcl.2012.09.112
		CHEMBL2207655	84084	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	638	9	4	8	2.2	CC1(O)CN(S(=O)(=O)c2ccc3c(C(=O)NC[C@@H](O)CN4CCC(Oc5ccc(Cl)c(Cl)c5)CC4)c[nH]c(=O)c3c2)C1	10.1016/j.bmcl.2012.09.112
		59296100	84088	0	None	-7	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	460	7	3	5	3.0	Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]nc2C(F)(F)F)CC1	10.1016/j.bmcl.2012.09.112
		CHEMBL2207659	84088	0	None	-7	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	460	7	3	5	3.0	Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]nc2C(F)(F)F)CC1	10.1016/j.bmcl.2012.09.112
		44396220	125423	1	None	1	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	295	6	0	2	4.1	c1ccc(Cc2ccccc2OCCN2CCCCC2)cc1	10.1021/acs.jmedchem.6b00981
		CHEMBL364565	125423	1	None	1	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	295	6	0	2	4.1	c1ccc(Cc2ccccc2OCCN2CCCCC2)cc1	10.1021/acs.jmedchem.6b00981
		134145957	154511	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	296	4	0	1	3.9	C[N+]1(C)CCC(Oc2ccccc2Cc2ccccc2)CC1	10.1021/acs.jmedchem.6b00981
		CHEMBL3944629	154511	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	296	4	0	1	3.9	C[N+]1(C)CCC(Oc2ccccc2Cc2ccccc2)CC1	10.1021/acs.jmedchem.6b00981
		CHEMBL3990701	154511	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	296	4	0	1	3.9	C[N+]1(C)CCC(Oc2ccccc2Cc2ccccc2)CC1	10.1021/acs.jmedchem.6b00981
		23102749	82234	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	525	6	1	5	4.3	Cc1c(Cl)ccc(OC2CCN(C3CCN(S(=O)(=O)NC(=O)c4ccccc4)CC3)CC2)c1Cl	10.1016/j.bmcl.2012.08.124
		CHEMBL2171016	82234	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	525	6	1	5	4.3	Cc1c(Cl)ccc(OC2CCN(C3CCN(S(=O)(=O)NC(=O)c4ccccc4)CC3)CC2)c1Cl	10.1016/j.bmcl.2012.08.124
		22397445	82239	0	None	-2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	499	4	1	4	5.0	O=C(c1c[nH]c(=O)c2ccccc12)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.124
		CHEMBL2171020	82239	0	None	-2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	499	4	1	4	5.0	O=C(c1c[nH]c(=O)c2ccccc12)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.124
		69826668	82240	0	None	-5	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	524	5	0	5	4.9	Cc1c(Cl)ccc(OC2CCN(C3CCN(C(=O)c4cccc(S(C)(=O)=O)c4)CC3)CC2)c1Cl	10.1016/j.bmcl.2012.08.124
		CHEMBL2171021	82240	0	None	-5	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	524	5	0	5	4.9	Cc1c(Cl)ccc(OC2CCN(C3CCN(C(=O)c4cccc(S(C)(=O)=O)c4)CC3)CC2)c1Cl	10.1016/j.bmcl.2012.08.124
		71449857	82242	0	None	10	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	476	5	1	4	4.8	O=C(O)c1ccccc1C(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.124
		CHEMBL2171023	82242	0	None	10	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	476	5	1	4	4.8	O=C(O)c1ccccc1C(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.124
		71453505	82260	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	554	6	1	6	4.5	CN(C)c1ccccc1S(=O)(=O)NC(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.124
		CHEMBL2171041	82260	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	554	6	1	6	4.5	CN(C)c1ccccc1S(=O)(=O)NC(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.124
		17963226	82267	0	None	-3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	505	5	1	5	4.4	Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)cc4C)CC3)CC2)cc1	10.1016/j.bmcl.2012.08.124
		CHEMBL2171048	82267	0	None	-3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	505	5	1	5	4.4	Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)cc4C)CC3)CC2)cc1	10.1016/j.bmcl.2012.08.124
		44343573	111057	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	369	2	0	3	3.5	CCC(=O)N1CCN(C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/s0960-894x(98)00626-x
		CHEMBL326289	111057	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	369	2	0	3	3.5	CCC(=O)N1CCN(C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/s0960-894x(98)00626-x
		44334406	4863	0	None	-660	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	462	10	1	5	3.8	O=C(c1ccc(OCCCN2CC[C@H](NS(=O)(=O)c3ccc(Cl)cc3)C2)cc1)C1CC1	10.1016/s0960-894x(02)00685-6
		CHEMBL104344	4863	0	None	-660	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	462	10	1	5	3.8	O=C(c1ccc(OCCCN2CC[C@H](NS(=O)(=O)c3ccc(Cl)cc3)C2)cc1)C1CC1	10.1016/s0960-894x(02)00685-6
		10472143	119277	0	None	-5623	16	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards Histamine H1 receptorBinding affinity towards Histamine H1 receptor	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
		CHEMBL343755	119277	0	None	-5623	16	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards Histamine H1 receptorBinding affinity towards Histamine H1 receptor	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
		59295960	84097	0	None	-12	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	532	8	4	6	2.6	NC(=O)c1c(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccccc34)CC2)ccc(Cl)c1Cl	10.1016/j.bmcl.2012.09.112
		CHEMBL2207667	84097	0	None	-12	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	532	8	4	6	2.6	NC(=O)c1c(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccccc34)CC2)ccc(Cl)c1Cl	10.1016/j.bmcl.2012.09.112
		59296041	84100	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	558	8	3	8	2.1	CS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(C#N)c(Cl)c4)CC3)c[nH]c(=O)c2c1	10.1016/j.bmcl.2012.09.112
		CHEMBL2207670	84100	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	558	8	3	8	2.1	CS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(C#N)c(Cl)c4)CC3)c[nH]c(=O)c2c1	10.1016/j.bmcl.2012.09.112
		18722998	154474	2	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	191	2	0	2	2.2	CN1CCC(Oc2ccccc2)CC1	10.1021/acs.jmedchem.6b00981
		CHEMBL3983211	154474	2	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	191	2	0	2	2.2	CN1CCC(Oc2ccccc2)CC1	10.1021/acs.jmedchem.6b00981
		CHEMBL3990343	154474	2	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	191	2	0	2	2.2	CN1CCC(Oc2ccccc2)CC1	10.1021/acs.jmedchem.6b00981
		46881468	6859	0	None	-10	3	Human	5.6	pKi	=	5.6	Binding	Activity at histamine H1 receptorActivity at histamine H1 receptor	ChEMBL	245	3	1	3	1.9	c1ccc(N2CCN(CC3CCCCN3)C2)cc1	10.1016/j.bmcl.2010.01.090
		CHEMBL1084132	6859	0	None	-10	3	Human	5.6	pKi	=	5.6	Binding	Activity at histamine H1 receptorActivity at histamine H1 receptor	ChEMBL	245	3	1	3	1.9	c1ccc(N2CCN(CC3CCCCN3)C2)cc1	10.1016/j.bmcl.2010.01.090
		10420190	206760	0	None	-2	3	Guinea pig	5.6	pKi	=	5.6	Binding	Binding affinity against H1 receptor of guinea pig by the displacement of [3H]mepyramine, bound to membranes of CHO cellsBinding affinity against H1 receptor of guinea pig by the displacement of [3H]mepyramine, bound to membranes of CHO cells	ChEMBL	195	8	2	2	2.3	NCCCCCCCCc1c[nH]cn1	10.1021/jm00002a008
		CHEMBL90063	206760	0	None	-2	3	Guinea pig	5.6	pKi	=	5.6	Binding	Binding affinity against H1 receptor of guinea pig by the displacement of [3H]mepyramine, bound to membranes of CHO cellsBinding affinity against H1 receptor of guinea pig by the displacement of [3H]mepyramine, bound to membranes of CHO cells	ChEMBL	195	8	2	2	2.3	NCCCCCCCCc1c[nH]cn1	10.1021/jm00002a008
		11533362	80632	0	None	-7943	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	497	6	0	6	3.4	CS(=O)(=O)c1ccc(C(=O)N2CCN(c3ccc(OC4CCN(C5CCC5)CC4)cc3)CC2)cc1	10.1021/jm100064d
		CHEMBL2151155	80632	0	None	-7943	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	497	6	0	6	3.4	CS(=O)(=O)c1ccc(C(=O)N2CCN(c3ccc(OC4CCN(C5CCC5)CC4)cc3)CC2)cc1	10.1021/jm100064d
		9976892	103954	42	None	-10715	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	377	4	0	4	4.0	O=C1CCCN1c1ccc(Oc2ccc3c(c2)CCN(C2CCC2)CC3)nc1	10.1016/j.bmcl.2013.09.090
		CHEMBL3092650	103954	42	None	-10715	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	377	4	0	4	4.0	O=C1CCCN1c1ccc(Oc2ccc3c(c2)CCN(C2CCC2)CC3)nc1	10.1016/j.bmcl.2013.09.090
		168292954	192997	0	None	-44	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	388	8	4	4	2.5	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2cnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5202592	192997	0	None	-44	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	388	8	4	4	2.5	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2cnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222660	192997	0	None	-44	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	388	8	4	4	2.5	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2cnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
		10039772	104361	0	None	-100	3	Guinea pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]mepyramine bound to membranes of CHO cells expressing guinea pig H1 receptorsDisplacement of [3H]mepyramine bound to membranes of CHO cells expressing guinea pig H1 receptors	ChEMBL	288	7	3	2	3.1	S=C(NCCCCCc1c[nH]cn1)Nc1ccccc1	10.1021/jm00012a025
		CHEMBL310087	104361	0	None	-100	3	Guinea pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]mepyramine bound to membranes of CHO cells expressing guinea pig H1 receptorsDisplacement of [3H]mepyramine bound to membranes of CHO cells expressing guinea pig H1 receptors	ChEMBL	288	7	3	2	3.1	S=C(NCCCCCc1c[nH]cn1)Nc1ccccc1	10.1021/jm00012a025
		112936341	137474	1	None	12	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	359	5	1	5	3.5	CN1CCN(c2nc(NCc3ccccc3)cc(-c3ccccc3)n2)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL3753849	137474	1	None	12	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	359	5	1	5	3.5	CN1CCN(c2nc(NCc3ccccc3)cc(-c3ccccc3)n2)CC1	10.1016/j.bmcl.2015.12.035
		10711079	98741	0	None	-1318	2	Guinea pig	4.6	pKi	=	4.6	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	323	5	2	3	3.4	O=C(Nc1ccc(Br)cc1)OCCCc1c[nH]cn1	10.1021/jm9507688
		CHEMBL277989	98741	0	None	-1318	2	Guinea pig	4.6	pKi	=	4.6	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	323	5	2	3	3.4	O=C(Nc1ccc(Br)cc1)OCCCc1c[nH]cn1	10.1021/jm9507688
		155515780	170024	0	None	-	1	Guinea pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysisDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysis	ChEMBL	318	6	0	4	1.8	CCN1CCc2ccc(OCCCN3CCOCC3)cc2C1=O	10.1016/j.bmcl.2019.04.015
		CHEMBL4442619	170024	0	None	-	1	Guinea pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysisDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysis	ChEMBL	318	6	0	4	1.8	CCN1CCc2ccc(OCCCN3CCOCC3)cc2C1=O	10.1016/j.bmcl.2019.04.015
		9947477	199968	0	None	-25	2	Rat	6.6	pKi	=	6.6	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	ChEMBL	368	10	2	3	4.6	Clc1ccc(C(CCNCCCCc2c[nH]cn2)c2ccccn2)cc1	10.1016/s0960-894x(03)00357-3
		CHEMBL59512	199968	0	None	-25	2	Rat	6.6	pKi	=	6.6	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	ChEMBL	368	10	2	3	4.6	Clc1ccc(C(CCNCCCCc2c[nH]cn2)c2ccccn2)cc1	10.1016/s0960-894x(03)00357-3
		95214051	162423	0	None	1	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	331	6	2	5	1.7	O=C(CO)NC[C@H]1CCN(Cc2csc(-c3ccccc3)n2)C1	10.1021/acs.jmedchem.8b00718
		CHEMBL4166178	162423	0	None	1	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	331	6	2	5	1.7	O=C(CO)NC[C@H]1CCN(Cc2csc(-c3ccccc3)n2)C1	10.1021/acs.jmedchem.8b00718
		44478385	5776	6	None	-446	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cellsDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells	ChEMBL	342	9	3	4	2.5	N#C/N=C(/NCCCCc1c[nH]cn1)NCCSc1ccccc1	10.1021/jm900526h
		CHEMBL1078642	5776	6	None	-446	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cellsDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells	ChEMBL	342	9	3	4	2.5	N#C/N=C(/NCCCCc1c[nH]cn1)NCCSc1ccccc1	10.1021/jm900526h
		164611474	185452	0	None	-407	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	366	6	4	5	2.4	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1cccs1	10.1016/j.ejmech.2021.113190
		CHEMBL4861704	185452	0	None	-407	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	366	6	4	5	2.4	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1cccs1	10.1016/j.ejmech.2021.113190
		9906978	42711	2	None	-28	12	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	361	6	1	3	4.0	O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1	10.1016/j.bmc.2008.06.030
		CHEMBL150161	42711	2	None	-28	12	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	361	6	1	3	4.0	O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1	10.1016/j.bmc.2008.06.030
		9906978	42711	2	None	-28	12	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human cloned histamine H1 receptor by radioligand binding assayBinding affinity to human cloned histamine H1 receptor by radioligand binding assay	ChEMBL	361	6	1	3	4.0	O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1	10.1016/j.bmcl.2006.03.057
		CHEMBL150161	42711	2	None	-28	12	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human cloned histamine H1 receptor by radioligand binding assayBinding affinity to human cloned histamine H1 receptor by radioligand binding assay	ChEMBL	361	6	1	3	4.0	O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1	10.1016/j.bmcl.2006.03.057
		9850828	169902	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsBinding affinity towards human histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	562	11	2	5	5.0	NC(=O)N(O)CCC#Cc1ccc(OCCCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1016/j.bmcl.2004.08.060
		CHEMBL444083	169902	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsBinding affinity towards human histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	562	11	2	5	5.0	NC(=O)N(O)CCC#Cc1ccc(OCCCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1016/j.bmcl.2004.08.060
		155547818	173568	0	None	2	2	Guinea pig	7.6	pKi	=	7.6	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysisDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysis	ChEMBL	302	5	0	3	2.6	CC1CCCN1CCCOc1ccc2c(c1)C(=O)N(C)CC2	10.1016/j.bmcl.2019.04.015
		CHEMBL4532574	173568	0	None	2	2	Guinea pig	7.6	pKi	=	7.6	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysisDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysis	ChEMBL	302	5	0	3	2.6	CC1CCCN1CCCOc1ccc2c(c1)C(=O)N(C)CC2	10.1016/j.bmcl.2019.04.015
		44449794	158262	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	333	5	1	4	3.5	COc1cc(Cl)ccc1O[C@H](c1ccccc1)[C@H]1CNCCO1	10.1016/j.bmcl.2008.03.050
		CHEMBL408868	158262	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	333	5	1	4	3.5	COc1cc(Cl)ccc1O[C@H](c1ccccc1)[C@H]1CNCCO1	10.1016/j.bmcl.2008.03.050
		11848679	89244	0	None	-204	6	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	489	9	3	9	2.9	CCOc1cc(CN2CCC(Nc3nc4cc(S(N)(=O)=O)ccc4o3)CC2)cc(OCC)c1N	10.1016/j.bmcl.2009.09.024
		CHEMBL236788	89244	0	None	-204	6	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	489	9	3	9	2.9	CCOc1cc(CN2CCC(Nc3nc4cc(S(N)(=O)=O)ccc4o3)CC2)cc(OCC)c1N	10.1016/j.bmcl.2009.09.024
		146025727	171685	0	None	-97	27	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4466483	171685	0	None	-97	27	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		71456046	84075	0	None	-1737	7	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation counting analysisDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation counting analysis	ChEMBL	389	6	0	4	4.2	COc1ccccc1N1CCN(Cc2cc(CN(C)C)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		CHEMBL2207637	84075	0	None	-1737	7	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation counting analysisDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation counting analysis	ChEMBL	389	6	0	4	4.2	COc1ccccc1N1CCN(Cc2cc(CN(C)C)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		44209472	70172	2	None	-144	11	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]pyrilamine from human H1 receptor by liquid scintillation countingDisplacement of [3H]pyrilamine from human H1 receptor by liquid scintillation counting	ChEMBL	315	6	0	4	2.8	Fc1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2011.12.019
		CHEMBL1940420	70172	2	None	-144	11	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]pyrilamine from human H1 receptor by liquid scintillation countingDisplacement of [3H]pyrilamine from human H1 receptor by liquid scintillation counting	ChEMBL	315	6	0	4	2.8	Fc1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2011.12.019
		1072350	69027	5	None	-4	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	269	3	0	5	2.2	c1ccc2c(c1)nc1n(CCN3CCCCC3)cnn21	10.1021/jm2011589
		CHEMBL1923529	69027	5	None	-4	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	269	3	0	5	2.2	c1ccc2c(c1)nc1n(CCN3CCCCC3)cnn21	10.1021/jm2011589
		44304978	167889	0	None	-1230	3	Human	4.6	pKi	=	4.6	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	396	11	0	5	2.8	CCCCCC(=O)c1ccc(OCCCN2CCN(S(C)(=O)=O)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL431172	167889	0	None	-1230	3	Human	4.6	pKi	=	4.6	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	396	11	0	5	2.8	CCCCCC(=O)c1ccc(OCCCN2CCN(S(C)(=O)=O)CC2)cc1	10.1016/s0960-894x(02)00309-8
		46230651	200508	0	None	-125	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]Pyrilamine from human cloned histamine H1 receptorDisplacement of [3H]Pyrilamine from human cloned histamine H1 receptor	ChEMBL	289	2	1	2	3.8	COc1ccc2c3c(ccc2c1)Cc1ccccc1C3CN	10.1016/j.bmcl.2009.12.064
		CHEMBL598753	200508	0	None	-125	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]Pyrilamine from human cloned histamine H1 receptorDisplacement of [3H]Pyrilamine from human cloned histamine H1 receptor	ChEMBL	289	2	1	2	3.8	COc1ccc2c3c(ccc2c1)Cc1ccccc1C3CN	10.1016/j.bmcl.2009.12.064
		164585622	184928	0	None	1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity to H1 receptor (unknown origin)Binding affinity to H1 receptor (unknown origin)	ChEMBL	506	6	2	7	5.5	O=C(O)c1cc(-c2ccc(-c3cc(CO)on3)cc2)cc(-n2cc(-c3ccc(C(F)(F)F)cc3)nn2)c1	10.1021/acs.jmedchem.1c00164
		CHEMBL4853466	184928	0	None	1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity to H1 receptor (unknown origin)Binding affinity to H1 receptor (unknown origin)	ChEMBL	506	6	2	7	5.5	O=C(O)c1cc(-c2ccc(-c3cc(CO)on3)cc2)cc(-n2cc(-c3ccc(C(F)(F)F)cc3)nn2)c1	10.1021/acs.jmedchem.1c00164
		24740863	89158	0	None	-3	6	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	385	6	1	5	5.0	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1Cl	10.1016/j.bmcl.2009.09.024
		CHEMBL236610	89158	0	None	-3	6	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	385	6	1	5	5.0	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1Cl	10.1016/j.bmcl.2009.09.024
		56781741	162635	4	None	1	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	337	6	0	6	3.0	Cc1cc(C)n(C2CN(CCCc3nc(-c4ccccc4)no3)C2)n1	10.1021/acs.jmedchem.8b00718
		CHEMBL4169603	162635	4	None	1	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	337	6	0	6	3.0	Cc1cc(C)n(C2CN(CCCc3nc(-c4ccccc4)no3)C2)n1	10.1021/acs.jmedchem.8b00718
		168291233	192979	0	None	-6	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	373	8	4	5	1.4	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)o2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5200106	192979	0	None	-6	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	373	8	4	5	1.4	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)o2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222556	192979	0	None	-6	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	373	8	4	5	1.4	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)o2)cc1	10.1021/acs.jmedchem.1c00692
		44326298	207909	0	None	3	3	Human	7.6	pKi	=	7.6	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	293	2	0	2	3.8	CN(C)CC1C[C@H]2c3ccccc3Cc3ccccc3[C@H]2O1	10.1016/j.bmcl.2004.03.069
		CHEMBL96732	207909	0	None	3	3	Human	7.6	pKi	=	7.6	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	293	2	0	2	3.8	CN(C)CC1C[C@H]2c3ccccc3Cc3ccccc3[C@H]2O1	10.1016/j.bmcl.2004.03.069
		1170	1633	75	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation counting	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1016/j.bmcl.2009.07.047
		3348	1633	75	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation counting	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1016/j.bmcl.2009.07.047
		4819	1633	75	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation counting	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1016/j.bmcl.2009.07.047
		74685737	1633	75	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation counting	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1016/j.bmcl.2009.07.047
		CHEMBL914	1633	75	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation counting	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1016/j.bmcl.2009.07.047
		DB00950	1633	75	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation counting	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1016/j.bmcl.2009.07.047
		44335237	5121	0	None	3	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	407	7	0	5	4.1	CCOC(=O)N1CCN(CCCOc2ccc(-c3ccc(C#N)cc3C)cc2)CC1	10.1016/s0960-894x(02)00648-0
		CHEMBL105669	5121	0	None	3	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	407	7	0	5	4.1	CCOC(=O)N1CCN(CCCOc2ccc(-c3ccc(C#N)cc3C)cc2)CC1	10.1016/s0960-894x(02)00648-0
		11963995	91865	0	None	-15	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	387	6	1	4	3.8	CCOc1cc(CN2CCC(NC(=O)c3cncc(C)c3)CC2)ccc1Cl	10.1021/jm701144e
		CHEMBL241329	91865	0	None	-15	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	387	6	1	4	3.8	CCOc1cc(CN2CCC(NC(=O)c3cncc(C)c3)CC2)ccc1Cl	10.1021/jm701144e
		49783209	17609	0	None	-1380	26	Guinea pig	5.6	pKi	=	5.6	Binding	Binding affinity to guinea pig histamine H1 receptorBinding affinity to guinea pig histamine H1 receptor	ChEMBL	396	7	1	6	3.8	CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1	10.1021/jm100668r
		CHEMBL1258223	17609	0	None	-1380	26	Guinea pig	5.6	pKi	=	5.6	Binding	Binding affinity to guinea pig histamine H1 receptorBinding affinity to guinea pig histamine H1 receptor	ChEMBL	396	7	1	6	3.8	CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1	10.1021/jm100668r
		409544	202914	4	None	-194	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	390	11	0	5	4.0	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)OCC)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL62803	202914	4	None	-194	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	390	11	0	5	4.0	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)OCC)CC2)cc1	10.1016/s0960-894x(02)00309-8
		44304383	203303	0	None	-27	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	418	12	0	5	4.6	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)OCC(C)C)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL64775	203303	0	None	-27	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	418	12	0	5	4.6	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)OCC(C)C)CC2)cc1	10.1016/s0960-894x(02)00309-8
		44335559	109709	0	None	-162	4	Human	6.6	pKi	=	6.6	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	334	6	0	3	4.7	CC1CCCN(CCCOc2ccc(-c3ccc(C#N)cc3)cc2)C1	10.1016/s0960-894x(02)00648-0
		CHEMBL322873	109709	0	None	-162	4	Human	6.6	pKi	=	6.6	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	334	6	0	3	4.7	CC1CCCN(CCCOc2ccc(-c3ccc(C#N)cc3)cc2)C1	10.1016/s0960-894x(02)00648-0
		79698	202192	95	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cellsDisplacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cells	ChEMBL	211	4	1	1	3.2	NCCC(c1ccccc1)c1ccccc1	10.1016/j.bmc.2009.08.016
		CHEMBL609579	202192	95	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cellsDisplacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cells	ChEMBL	211	4	1	1	3.2	NCCC(c1ccccc1)c1ccccc1	10.1016/j.bmc.2009.08.016
		25450664	161996	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	392	6	0	6	3.9	COC(=O)c1ccc(-c2nc(CN(C)C[C@@H]3Cc4ccccc4O3)c(C)o2)cc1	10.1021/acs.jmedchem.8b00718
		CHEMBL4159365	161996	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	392	6	0	6	3.9	COC(=O)c1ccc(-c2nc(CN(C)C[C@@H]3Cc4ccccc4O3)c(C)o2)cc1	10.1021/acs.jmedchem.8b00718
		242	470	124	None	-22	51	Human	7.6	pKi	=	7.6	Binding	Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
		34	470	124	None	-22	51	Human	7.6	pKi	=	7.6	Binding	Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
		60795	470	124	None	-22	51	Human	7.6	pKi	=	7.6	Binding	Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
		CHEMBL1112	470	124	None	-22	51	Human	7.6	pKi	=	7.6	Binding	Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
		DB01238	470	124	None	-22	51	Human	7.6	pKi	=	7.6	Binding	Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
		53322839	57766	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	373	7	0	5	3.8	C[C@H](C1=C(CCN(C)Cc2nccn2C)Cc2ccccc21)c1cnccn1	10.1016/j.bmcl.2010.12.053
		CHEMBL1669423	57766	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	373	7	0	5	3.8	C[C@H](C1=C(CCN(C)Cc2nccn2C)Cc2ccccc21)c1cnccn1	10.1016/j.bmcl.2010.12.053
		11808040	168395	0	None	-2	6	Human	7.5	pKi	=	7.5	Binding	Compound was evaluated for binding affinity towards cloned human histamine H1 receptors stably expressed in CHO-K1 cells using [3H]mepyramineCompound was evaluated for binding affinity towards cloned human histamine H1 receptors stably expressed in CHO-K1 cells using [3H]mepyramine	ChEMBL	278	4	0	2	3.8	CC(C1=C(CN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL434684	168395	0	None	-2	6	Human	7.5	pKi	=	7.5	Binding	Compound was evaluated for binding affinity towards cloned human histamine H1 receptors stably expressed in CHO-K1 cells using [3H]mepyramineCompound was evaluated for binding affinity towards cloned human histamine H1 receptors stably expressed in CHO-K1 cells using [3H]mepyramine	ChEMBL	278	4	0	2	3.8	CC(C1=C(CN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		46929647	16758	0	None	-19	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	355	5	2	3	4.3	FC(F)(F)c1ccc(SC[C@H](c2c[nH]cn2)C2CCNCC2)cc1	10.1021/jm100643t
		CHEMBL1243394	16758	0	None	-19	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	355	5	2	3	4.3	FC(F)(F)c1ccc(SC[C@H](c2c[nH]cn2)C2CCNCC2)cc1	10.1021/jm100643t
		28357663	162144	2	None	1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	301	5	0	3	3.3	Cc1ccn(CCN2CCC(Cc3ccccc3F)CC2)n1	10.1021/acs.jmedchem.8b00718
		CHEMBL4161837	162144	2	None	1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	301	5	0	3	3.3	Cc1ccn(CCN2CCC(Cc3ccccc3F)CC2)n1	10.1021/acs.jmedchem.8b00718
		49841846	69738	0	None	-812	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human H1 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H1 receptor expressed in HEK cell membranes	ChEMBL	325	2	1	6	2.7	CN1CCN(c2nc(N)nc3cc(-c4ccsc4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935572	69738	0	None	-812	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]histamine from human H1 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H1 receptor expressed in HEK cell membranes	ChEMBL	325	2	1	6	2.7	CN1CCN(c2nc(N)nc3cc(-c4ccsc4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
		10451094	202473	0	None	-56234	3	Human	4.6	pKi	=	4.6	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	359	9	1	5	1.5	NCCC(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		CHEMBL61120	202473	0	None	-56234	3	Human	4.6	pKi	=	4.6	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	359	9	1	5	1.5	NCCC(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		127038376	136783	0	None	-323	5	Guinea pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellumDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum	ChEMBL	502	6	0	7	4.2	O=[N+]([O-])c1ccc(S(=O)(=O)N2CCC(CN3CCC(c4noc5cc(F)ccc45)CC3)CC2)cc1	10.1039/C4MD00578C
		CHEMBL3741292	136783	0	None	-323	5	Guinea pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellumDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum	ChEMBL	502	6	0	7	4.2	O=[N+]([O-])c1ccc(S(=O)(=O)N2CCC(CN3CCC(c4noc5cc(F)ccc45)CC3)CC2)cc1	10.1039/C4MD00578C
		44304751	101023	0	None	-7	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	422	11	0	4	4.7	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3ccccc3)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL294519	101023	0	None	-7	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	422	11	0	4	4.7	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3ccccc3)CC2)cc1	10.1016/s0960-894x(02)00309-8
		44335225	164155	0	None	-190	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	347	6	1	4	3.1	N#Cc1ccc(-c2ccc(OCCCN3CC4CNCC4C3)cc2)cc1	10.1016/s0960-894x(02)00648-0
		CHEMBL421026	164155	0	None	-190	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	347	6	1	4	3.1	N#Cc1ccc(-c2ccc(OCCCN3CC4CNCC4C3)cc2)cc1	10.1016/s0960-894x(02)00648-0
		168294178	193035	0	None	-1	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	414	5	4	4	4.4	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)C2CCCCC2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5205197	193035	0	None	-1	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	414	5	4	4	4.4	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)C2CCCCC2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222887	193035	0	None	-1	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	414	5	4	4	4.4	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)C2CCCCC2)cc1	10.1021/acs.jmedchem.1c00692
		164627241	186429	0	None	-95	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	438	6	4	4	3.1	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccc(Br)cc1	10.1016/j.ejmech.2021.113190
		CHEMBL4876267	186429	0	None	-95	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	438	6	4	4	3.1	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccc(Br)cc1	10.1016/j.ejmech.2021.113190
		164627189	186321	0	None	-275	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	298	6	4	4	1.0	CCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1016/j.ejmech.2021.113190
		CHEMBL4874758	186321	0	None	-275	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	298	6	4	4	1.0	CCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1016/j.ejmech.2021.113190
		118721929	116093	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting method	ChEMBL	394	2	0	2	5.3	CC(C)CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/jm501086v
		CHEMBL3357042	116093	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting method	ChEMBL	394	2	0	2	5.3	CC(C)CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/jm501086v
		162645254	179683	3	None	-371	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cell membranes co-expressing RGS4 measured after 60 mins by scintillation counting analysisDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cell membranes co-expressing RGS4 measured after 60 mins by scintillation counting analysis	ChEMBL	398	7	0	5	4.2	N#Cc1ccc(-c2ccc(OCCCN3CCN(c4ccncc4)CC3)cc2)cc1	10.1016/j.ejmech.2020.113041
		CHEMBL4743583	179683	3	None	-371	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cell membranes co-expressing RGS4 measured after 60 mins by scintillation counting analysisDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cell membranes co-expressing RGS4 measured after 60 mins by scintillation counting analysis	ChEMBL	398	7	0	5	4.2	N#Cc1ccc(-c2ccc(OCCCN3CCN(c4ccncc4)CC3)cc2)cc1	10.1016/j.ejmech.2020.113041
		24841480	183899	0	None	-14	20	Human	7.5	pKi	=	7.5	Binding	Antagonist activity at histamine H1 receptor (unknown origin) by PDSP assayAntagonist activity at histamine H1 receptor (unknown origin) by PDSP assay	ChEMBL	340	3	0	4	4.5	O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
		CHEMBL481153	183899	0	None	-14	20	Human	7.5	pKi	=	7.5	Binding	Antagonist activity at histamine H1 receptor (unknown origin) by PDSP assayAntagonist activity at histamine H1 receptor (unknown origin) by PDSP assay	ChEMBL	340	3	0	4	4.5	O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
		9928323	11937	0	None	-	1	Guinea pig	7.5	pKi	=	7.5	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	349	5	1	3	4.1	CN(C)CC/C=C1/c2ccccc2COc2ccc(/C=C/C(=O)O)cc21	10.1021/jm00089a020
		CHEMBL1182766	11937	0	None	-	1	Guinea pig	7.5	pKi	=	7.5	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	349	5	1	3	4.1	CN(C)CC/C=C1/c2ccccc2COc2ccc(/C=C/C(=O)O)cc21	10.1021/jm00089a020
		CHEMBL264979	11937	0	None	-	1	Guinea pig	7.5	pKi	=	7.5	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	349	5	1	3	4.1	CN(C)CC/C=C1/c2ccccc2COc2ccc(/C=C/C(=O)O)cc21	10.1021/jm00089a020
		44326433	207858	0	None	1	3	Human	7.5	pKi	=	7.5	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	409	3	0	2	6.1	c1ccc(C2CCN(CC3C[C@@H]4c5ccccc5Cc5ccccc5[C@H]4O3)CC2)cc1	10.1016/j.bmcl.2004.03.069
		CHEMBL96471	207858	0	None	1	3	Human	7.5	pKi	=	7.5	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	409	3	0	2	6.1	c1ccc(C2CCN(CC3C[C@@H]4c5ccccc5Cc5ccccc5[C@H]4O3)CC2)cc1	10.1016/j.bmcl.2004.03.069
		23551948	110396	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	341	2	0	3	2.7	O=CN1CCN(C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/s0960-894x(98)00626-x
		CHEMBL324336	110396	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	341	2	0	3	2.7	O=CN1CCN(C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/s0960-894x(98)00626-x
		162647537	179804	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity to H1 receptor (unknown origin)Binding affinity to H1 receptor (unknown origin)	ChEMBL	294	3	0	2	3.0	CN(C)CCN1C(=O)c2ccccc2CCc2ccccc21	10.1016/j.bmcl.2020.127493
		CHEMBL4744893	179804	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity to H1 receptor (unknown origin)Binding affinity to H1 receptor (unknown origin)	ChEMBL	294	3	0	2	3.0	CN(C)CCN1C(=O)c2ccccc2CCc2ccccc21	10.1016/j.bmcl.2020.127493
		14885640	16778	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	340	3	0	2	4.1	CC(=O)N(C)CC/C=C1\c2ccc(Cl)cc2CCc2cccnc21	10.1021/jm00105a069
		CHEMBL124466	16778	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	340	3	0	2	4.1	CC(=O)N(C)CC/C=C1\c2ccc(Cl)cc2CCc2cccnc21	10.1021/jm00105a069
		9928224	134357	0	None	-1621	3	Guinea pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-alpha-methylhistamine from histamine H1 receptor in guinea pig brainDisplacement of [3H]N-alpha-methylhistamine from histamine H1 receptor in guinea pig brain	ChEMBL	346	6	2	3	3.3	O=C(CCN1CCC(Cc2c[nH]cn2)CC1)Nc1ccc(Cl)cc1	10.1016/j.bmcl.2005.09.076
		CHEMBL371730	134357	0	None	-1621	3	Guinea pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-alpha-methylhistamine from histamine H1 receptor in guinea pig brainDisplacement of [3H]N-alpha-methylhistamine from histamine H1 receptor in guinea pig brain	ChEMBL	346	6	2	3	3.3	O=C(CCN1CCC(Cc2c[nH]cn2)CC1)Nc1ccc(Cl)cc1	10.1016/j.bmcl.2005.09.076
		14885629	34978	0	None	-	1	Rat	5.5	pKi	=	5.5	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	336	0	0	2	3.8	CC(=O)N1CCC(=C2c3cc(F)ccc3CCc3cccnc32)CC1	10.1021/jm00105a069
		CHEMBL143272	34978	0	None	-	1	Rat	5.5	pKi	=	5.5	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	336	0	0	2	3.8	CC(=O)N1CCC(=C2c3cc(F)ccc3CCc3cccnc32)CC1	10.1021/jm00105a069
		162653991	180547	0	None	-245	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-pyrilamine from human H1 histamine receptor expressed in human HEK293 cellsDisplacement of [3H]-pyrilamine from human H1 histamine receptor expressed in human HEK293 cells	ChEMBL	470	4	0	3	6.0	C[C@H]1CN(CC[C@H]2CC[C@H](N3C(=O)CC4(CCCC4)CC3=O)CC2)CCc2ccc(Cl)cc21	10.1016/j.bmcl.2020.127681
		CHEMBL4753808	180547	0	None	-245	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-pyrilamine from human H1 histamine receptor expressed in human HEK293 cellsDisplacement of [3H]-pyrilamine from human H1 histamine receptor expressed in human HEK293 cells	ChEMBL	470	4	0	3	6.0	C[C@H]1CN(CC[C@H]2CC[C@H](N3C(=O)CC4(CCCC4)CC3=O)CC2)CCc2ccc(Cl)cc21	10.1016/j.bmcl.2020.127681
		10347051	67161	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsBinding affinity towards human histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	534	9	2	5	4.3	NC(=O)N(O)CCC#Cc1ccc(OCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1016/j.bmcl.2004.08.060
		CHEMBL187637	67161	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsBinding affinity towards human histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	534	9	2	5	4.3	NC(=O)N(O)CCC#Cc1ccc(OCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1016/j.bmcl.2004.08.060
		44591135	190177	0	None	-190	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	532	10	0	4	8.0	CN(CC/C=C1\c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
		CHEMBL517407	190177	0	None	-190	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	532	10	0	4	8.0	CN(CC/C=C1\c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
		90654501	110309	0	None	-31622	3	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	314	6	0	5	3.1	Cc1nnc(C)n1-c1ccc(OCCCN2CCCCC2)cc1	10.1016/j.ejmech.2014.03.014
		CHEMBL3238444	110309	0	None	-31622	3	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	314	6	0	5	3.1	Cc1nnc(C)n1-c1ccc(OCCCN2CCCCC2)cc1	10.1016/j.ejmech.2014.03.014
		132060734	163124	0	None	3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-Pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	391	5	0	4	4.0	C=C(C)CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1	10.1016/j.ejmech.2018.02.024
		CHEMBL4177497	163124	0	None	3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-Pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	391	5	0	4	4.0	C=C(C)CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1	10.1016/j.ejmech.2018.02.024
		44326427	107516	0	None	144	3	Human	8.5	pKi	=	8.5	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	348	2	0	3	3.5	CN1CCN(CC2C[C@@H]3c4ccccc4Cc4ccccc4[C@H]3O2)CC1	10.1016/j.bmcl.2004.03.069
		CHEMBL318659	107516	0	None	144	3	Human	8.5	pKi	=	8.5	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	348	2	0	3	3.5	CN1CCN(CC2C[C@@H]3c4ccccc4Cc4ccccc4[C@H]3O2)CC1	10.1016/j.bmcl.2004.03.069
		2247	505	81	None	-4	42	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards histamine H1 receptorBinding affinity towards histamine H1 receptor	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1021/jm0205651
		249	505	81	None	-4	42	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards histamine H1 receptorBinding affinity towards histamine H1 receptor	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1021/jm0205651
		2603	505	81	None	-4	42	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards histamine H1 receptorBinding affinity towards histamine H1 receptor	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1021/jm0205651
		CHEMBL296419	505	81	None	-4	42	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards histamine H1 receptorBinding affinity towards histamine H1 receptor	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1021/jm0205651
		DB00637	505	81	None	-4	42	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards histamine H1 receptorBinding affinity towards histamine H1 receptor	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1021/jm0205651
		10361564	51292	0	None	1	3	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptorDisplacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptor	ChEMBL	366	5	0	4	4.1	Cn1c(=O)sc2cc(CCN3CCC(Cc4ccccc4)CC3)ccc21	10.1016/s0960-894x(02)00123-3
		CHEMBL15809	51292	0	None	1	3	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptorDisplacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptor	ChEMBL	366	5	0	4	4.1	Cn1c(=O)sc2cc(CCN3CCC(Cc4ccccc4)CC3)ccc21	10.1016/s0960-894x(02)00123-3
		10399921	119805	0	None	4	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cellsDisplacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cells	ChEMBL	251	4	1	1	3.7	CNCCCC1c2ccccc2Cc2ccccc21	10.1016/j.bmc.2009.08.016
		CHEMBL348302	119805	0	None	4	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cellsDisplacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cells	ChEMBL	251	4	1	1	3.7	CNCCCC1c2ccccc2Cc2ccccc21	10.1016/j.bmc.2009.08.016
		46884731	7909	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	323	6	0	4	3.6	COc1ccc2c(c1)CC(CCN(C)C)=C2[C@@H](C)c1cnccn1	10.1016/j.bmcl.2010.02.055
		CHEMBL1090175	7909	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	323	6	0	4	3.6	COc1ccc2c(c1)CC(CCN(C)C)=C2[C@@H](C)c1cnccn1	10.1016/j.bmcl.2010.02.055
		46884667	8287	0	None	1174	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	312	5	0	3	4.5	Cc1csc([C@H](C)C2=C(CCN(C)C)Cc3ccccc32)n1	10.1016/j.bmcl.2010.02.055
		CHEMBL1092599	8287	0	None	1174	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	312	5	0	3	4.5	Cc1csc([C@H](C)C2=C(CCN(C)C)Cc3ccccc32)n1	10.1016/j.bmcl.2010.02.055
		6075	150108	42	None	2	16	Human	8.5	pKi	=	8.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
		CHEMBL395110	150108	42	None	2	16	Human	8.5	pKi	=	8.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
		24824726	161109	1	None	2	6	Human	8.5	pKi	=	8.5	Binding	Antagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysisAntagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysis	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL4060529	161109	1	None	2	6	Human	8.5	pKi	=	8.5	Binding	Antagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysisAntagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysis	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL4117079	161109	1	None	2	6	Human	8.5	pKi	=	8.5	Binding	Antagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysisAntagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysis	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL5282336	161109	1	None	2	6	Human	8.5	pKi	=	8.5	Binding	Antagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysisAntagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysis	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL5286389	161109	1	None	2	6	Human	8.5	pKi	=	8.5	Binding	Antagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysisAntagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysis	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL5284242	194615	0	None	56	3	Human	8.5	pKi	=	8.5	Binding	Antagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysisAntagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysis	ChEMBL	510	11	0	6	4.0	COCCCC(=O)N(C)CCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL5315342	194615	0	None	56	3	Human	8.5	pKi	=	8.5	Binding	Antagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysisAntagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysis	ChEMBL	510	11	0	6	4.0	COCCCC(=O)N(C)CCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		75306277	109254	0	None	-1	23	Human	8.5	pKi	=	8.5	Binding	Binding affinity to H1 histamine receptor (unknown origin) by PDSP assayBinding affinity to H1 histamine receptor (unknown origin) by PDSP assay	ChEMBL	308	0	0	3	4.2	CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3	10.1039/C2MD00311B
		CHEMBL3217984	109254	0	None	-1	23	Human	8.5	pKi	=	8.5	Binding	Binding affinity to H1 histamine receptor (unknown origin) by PDSP assayBinding affinity to H1 histamine receptor (unknown origin) by PDSP assay	ChEMBL	308	0	0	3	4.2	CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3	10.1039/C2MD00311B
		71463287	84202	0	None	79	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	420	7	1	5	4.1	N#Cc1cccc(OC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1	10.1016/j.bmcl.2012.09.113
		CHEMBL2208419	84202	0	None	79	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	420	7	1	5	4.1	N#Cc1cccc(OC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1	10.1016/j.bmcl.2012.09.113
		155515934	170015	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	402	2	0	4	4.7	Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(Cc2ncccn2)CC1	10.1021/acs.jmedchem.9b00447
		CHEMBL4442502	170015	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	402	2	0	4	4.7	Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(Cc2ncccn2)CC1	10.1021/acs.jmedchem.9b00447
		89474811	172906	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	401	2	0	3	5.3	Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(Cc2ccccn2)CC1	10.1021/acs.jmedchem.9b00447
		CHEMBL4516137	172906	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	401	2	0	3	5.3	Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(Cc2ccccn2)CC1	10.1021/acs.jmedchem.9b00447
		155567448	175982	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	350	1	0	2	4.9	Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(C2CC2)CC1	10.1021/acs.jmedchem.9b00447
		CHEMBL4588726	175982	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	350	1	0	2	4.9	Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(C2CC2)CC1	10.1021/acs.jmedchem.9b00447
		4671324	13196	2	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	269	7	0	2	3.6	CN(C)CCCOc1ccccc1Cc1ccccc1	10.1021/acs.jmedchem.6b00981
		CHEMBL1191054	13196	2	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	269	7	0	2	3.6	CN(C)CCCOc1ccccc1Cc1ccccc1	10.1021/acs.jmedchem.6b00981
		CHEMBL3955589	13196	2	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	269	7	0	2	3.6	CN(C)CCCOc1ccccc1Cc1ccccc1	10.1021/acs.jmedchem.6b00981
		45268653	195729	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	382	6	1	5	3.1	CN(CCO)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1	10.1016/j.bmcl.2009.05.086
		CHEMBL557210	195729	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	382	6	1	5	3.1	CN(CCO)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1	10.1016/j.bmcl.2009.05.086
		3191	102858	97	None	2	25	Human	8.5	pKi	=	8.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
		CHEMBL305660	102858	97	None	2	25	Human	8.5	pKi	=	8.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
		103	4153	61	None	-1	53	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm030480f
		2875	4153	61	None	-1	53	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm030480f
		5736	4153	61	None	-1	53	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm030480f
		CHEMBL285802	4153	61	None	-1	53	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm030480f
		DB09225	4153	61	None	-1	53	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm030480f
		69314950	78660	0	None	4	3	Human	8.5	pKi	=	8.5	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	279	2	1	2	3.4	CNC[C@@H]1C[C@H]2c3ccccc3Cc3ccccc3[C@@H]2O1	10.1016/j.bmcl.2004.03.069
		CHEMBL2112371	78660	0	None	4	3	Human	8.5	pKi	=	8.5	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	279	2	1	2	3.4	CNC[C@@H]1C[C@H]2c3ccccc3Cc3ccccc3[C@@H]2O1	10.1016/j.bmcl.2004.03.069
		135398745	2914	112	None	1	65	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm030480f
		47	2914	112	None	1	65	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm030480f
		CHEMBL715	2914	112	None	1	65	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm030480f
		DB00334	2914	112	None	1	65	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm030480f
		70941112	175390	5	None	117	2	Guinea pig	8.4	pKi	=	8.4	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysisDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysis	ChEMBL	288	6	1	3	2.3	NC(=O)c1ccc(OCCCN2C[C@H]3CCC[C@H]3C2)cc1	10.1016/j.bmcl.2019.04.015
		CHEMBL4575319	175390	5	None	117	2	Guinea pig	8.4	pKi	=	8.4	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysisDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysis	ChEMBL	288	6	1	3	2.3	NC(=O)c1ccc(OCCCN2C[C@H]3CCC[C@H]3C2)cc1	10.1016/j.bmcl.2019.04.015
		49782791	17910	0	None	-8	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsDisplacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	381	3	1	4	3.3	CC(=O)NCc1ccc2c(c1)[C@H](N1CCN(C)CC1)Cc1ccccc1S2	10.1021/jm100652h
		CHEMBL1259173	17910	0	None	-8	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsDisplacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	381	3	1	4	3.3	CC(=O)NCc1ccc2c(c1)[C@H](N1CCN(C)CC1)Cc1ccccc1S2	10.1021/jm100652h
		45271167	195364	0	None	977	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	428	6	0	4	5.3	CN(Cc1ccccc1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1	10.1016/j.bmcl.2009.05.086
		CHEMBL551888	195364	0	None	977	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	428	6	0	4	5.3	CN(Cc1ccccc1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1	10.1016/j.bmcl.2009.05.086
		9850828	169902	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity for recombinant human Histamine H1 receptor expressed in CHO K1 cellsBinding affinity for recombinant human Histamine H1 receptor expressed in CHO K1 cells	ChEMBL	562	11	2	5	5.0	NC(=O)N(O)CCC#Cc1ccc(OCCCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1016/j.bmcl.2004.12.023
		CHEMBL444083	169902	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity for recombinant human Histamine H1 receptor expressed in CHO K1 cellsBinding affinity for recombinant human Histamine H1 receptor expressed in CHO K1 cells	ChEMBL	562	11	2	5	5.0	NC(=O)N(O)CCC#Cc1ccc(OCCCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1016/j.bmcl.2004.12.023
		44326407	207159	0	None	23	3	Human	8.4	pKi	=	8.4	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	378	4	1	4	2.8	OCCN1CCN(CC2C[C@@H]3c4ccccc4Cc4ccccc4[C@H]3O2)CC1	10.1016/j.bmcl.2004.03.069
		CHEMBL92337	207159	0	None	23	3	Human	8.4	pKi	=	8.4	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	378	4	1	4	2.8	OCCN1CCN(CC2C[C@@H]3c4ccccc4Cc4ccccc4[C@H]3O2)CC1	10.1016/j.bmcl.2004.03.069
		44326690	111472	0	None	7	3	Human	8.4	pKi	=	8.4	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	293	2	0	2	3.8	CN(C)C[C@@H]1C[C@H]2c3ccccc3Cc3ccccc3[C@@H]2O1	10.1016/j.bmcl.2004.03.069
		CHEMBL327651	111472	0	None	7	3	Human	8.4	pKi	=	8.4	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	293	2	0	2	3.8	CN(C)C[C@@H]1C[C@H]2c3ccccc3Cc3ccccc3[C@@H]2O1	10.1016/j.bmcl.2004.03.069
		11976	920	59	None	-4	24	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1016/j.bmcl.2008.09.012
		667467	920	59	None	-4	24	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1016/j.bmcl.2008.09.012
		CHEMBL908	920	59	None	-4	24	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1016/j.bmcl.2008.09.012
		DB01239	920	59	None	-4	24	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1016/j.bmcl.2008.09.012
		135398737	958	93	None	-2	89	Guinea pig	8.4	pKi	=	8.4	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysisDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm400408r
		38	958	93	None	-2	89	Guinea pig	8.4	pKi	=	8.4	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysisDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm400408r
		722	958	93	None	-2	89	Guinea pig	8.4	pKi	=	8.4	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysisDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm400408r
		CHEMBL42	958	93	None	-2	89	Guinea pig	8.4	pKi	=	8.4	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysisDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm400408r
		DB00363	958	93	None	-2	89	Guinea pig	8.4	pKi	=	8.4	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysisDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm400408r
		19861	207523	50	None	-	1	Rat	8.4	pKi	=	8.4	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1021/jm00105a069
		CHEMBL946	207523	50	None	-	1	Rat	8.4	pKi	=	8.4	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1021/jm00105a069
		46884063	8141	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	322	5	0	3	4.7	C[C@@H](c1ccccn1)c1c(CCN2CCC2)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		CHEMBL1091775	8141	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	322	5	0	3	4.7	C[C@@H](c1ccccn1)c1c(CCN2CCC2)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		44250284	195222	0	None	1230	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	436	6	0	5	4.6	CN(CC1CCOCC1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1	10.1016/j.bmcl.2009.05.086
		CHEMBL550818	195222	0	None	1230	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	436	6	0	5	4.6	CN(CC1CCOCC1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1	10.1016/j.bmcl.2009.05.086
		44250284	195222	0	None	1230	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation counting	ChEMBL	436	6	0	5	4.6	CN(CC1CCOCC1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1	10.1016/j.bmcl.2010.03.027
		CHEMBL550818	195222	0	None	1230	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation counting	ChEMBL	436	6	0	5	4.6	CN(CC1CCOCC1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1	10.1016/j.bmcl.2010.03.027
		CHEMBL5276489	194643	0	None	70	3	Human	8.4	pKi	=	8.4	Binding	Antagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysisAntagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysis	ChEMBL	492	8	1	5	4.4	O=C(NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O)C1CCCC1	10.1021/acsmedchemlett.7b00112
		CHEMBL5315725	194643	0	None	70	3	Human	8.4	pKi	=	8.4	Binding	Antagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysisAntagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysis	ChEMBL	492	8	1	5	4.4	O=C(NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O)C1CCCC1	10.1021/acsmedchemlett.7b00112
		CHEMBL5275284	194654	0	None	5	3	Human	8.4	pKi	=	8.4	Binding	Antagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysisAntagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysis	ChEMBL	466	8	1	5	3.9	CC(C)C(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL5315872	194654	0	None	5	3	Human	8.4	pKi	=	8.4	Binding	Antagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysisAntagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysis	ChEMBL	466	8	1	5	3.9	CC(C)C(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		9870185	84096	0	None	-2	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	489	7	3	5	3.5	O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2ccccc12	10.1016/j.bmcl.2012.09.113
		CHEMBL2207666	84096	0	None	-2	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	489	7	3	5	3.5	O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2ccccc12	10.1016/j.bmcl.2012.09.113
		59296104	84216	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	503	7	2	5	3.8	CN(C[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)C(=O)c1c[nH]c(=O)c2ccccc12	10.1016/j.bmcl.2012.09.113
		CHEMBL2208433	84216	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	503	7	2	5	3.8	CN(C[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)C(=O)c1c[nH]c(=O)c2ccccc12	10.1016/j.bmcl.2012.09.113
		59295994	84217	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	489	7	3	5	3.5	O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1cc(=O)[nH]c2ccccc12	10.1016/j.bmcl.2012.09.113
		CHEMBL2208434	84217	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	489	7	3	5	3.5	O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1cc(=O)[nH]c2ccccc12	10.1016/j.bmcl.2012.09.113
		59296090	84092	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	507	7	3	5	3.3	O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)cc1C(F)(F)F	10.1016/j.bmcl.2012.09.112
		CHEMBL2207662	84092	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	507	7	3	5	3.3	O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)cc1C(F)(F)F	10.1016/j.bmcl.2012.09.112
		9870185	84096	0	None	-2	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	489	7	3	5	3.5	O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2ccccc12	10.1016/j.bmcl.2012.09.112
		CHEMBL2207666	84096	0	None	-2	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	489	7	3	5	3.5	O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2ccccc12	10.1016/j.bmcl.2012.09.112
		10103	3416	72	None	25	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	415	2	0	3	5.6	Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1021/acs.jmedchem.9b00447
		133017	3416	72	None	25	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	415	2	0	3	5.6	Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1021/acs.jmedchem.9b00447
		2413	3416	72	None	25	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	415	2	0	3	5.6	Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1021/acs.jmedchem.9b00447
		CHEMBL91397	3416	72	None	25	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	415	2	0	3	5.6	Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1021/acs.jmedchem.9b00447
		DB11614	3416	72	None	25	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	415	2	0	3	5.6	Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1021/acs.jmedchem.9b00447
		155523802	170857	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	400	2	0	2	5.9	Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(Cc2ccccc2)CC1	10.1021/acs.jmedchem.9b00447
		CHEMBL4454015	170857	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	400	2	0	2	5.9	Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(Cc2ccccc2)CC1	10.1021/acs.jmedchem.9b00447
		155537274	172263	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	378	1	0	2	5.7	Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(C2CCCC2)CC1	10.1021/acs.jmedchem.9b00447
		CHEMBL4474559	172263	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	378	1	0	2	5.7	Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(C2CCCC2)CC1	10.1021/acs.jmedchem.9b00447
		168276508	190266	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]mepyramine from human H1R expressed in HEK293T cells by radioligand competition binding assayDisplacement of [3H]mepyramine from human H1R expressed in HEK293T cells by radioligand competition binding assay	ChEMBL	1140	28	6	11	6.9	C[C@@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](C)C(=O)N[C@H](C)C(=O)NCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1	10.1021/acs.jmedchem.2c00125
		CHEMBL5175488	190266	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]mepyramine from human H1R expressed in HEK293T cells by radioligand competition binding assayDisplacement of [3H]mepyramine from human H1R expressed in HEK293T cells by radioligand competition binding assay	ChEMBL	1140	28	6	11	6.9	C[C@@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](C)C(=O)N[C@H](C)C(=O)NCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1	10.1021/acs.jmedchem.2c00125
		44395497	66832	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsBinding affinity towards human histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	560	11	2	5	5.4	NC(=O)N(O)CCC#Cc1ccc(OCCCCN2CCN([C@H](c3ccccc3)c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmcl.2004.08.060
		CHEMBL186125	66832	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsBinding affinity towards human histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	560	11	2	5	5.4	NC(=O)N(O)CCC#Cc1ccc(OCCCCN2CCN([C@H](c3ccccc3)c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmcl.2004.08.060
		9998826	120477	0	None	-69	5	Rat	7.5	pKi	=	7.5	Binding	Inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat cortexInhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat cortex	ChEMBL	363	5	1	3	3.1	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccccc1	10.1021/jm950759z
		CHEMBL354210	120477	0	None	-69	5	Rat	7.5	pKi	=	7.5	Binding	Inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat cortexInhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat cortex	ChEMBL	363	5	1	3	3.1	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccccc1	10.1021/jm950759z
		72152556	162938	4	None	-2	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	335	5	1	5	2.5	Fc1ccc(N2CCN(CCNc3cncc(Cl)n3)CC2)cc1	10.1021/acs.jmedchem.8b00718
		CHEMBL4174330	162938	4	None	-2	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	335	5	1	5	2.5	Fc1ccc(N2CCN(CCNc3cncc(Cl)n3)CC2)cc1	10.1021/acs.jmedchem.8b00718
		44288769	101148	0	None	-275	7	Human	6.5	pKi	=	6.5	Binding	Selectivity screen against human Histamine H1 receptorSelectivity screen against human Histamine H1 receptor	ChEMBL	542	7	1	4	4.5	CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3F)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C	10.1016/s0960-894x(99)00696-4
		CHEMBL295395	101148	0	None	-275	7	Human	6.5	pKi	=	6.5	Binding	Selectivity screen against human Histamine H1 receptorSelectivity screen against human Histamine H1 receptor	ChEMBL	542	7	1	4	4.5	CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3F)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C	10.1016/s0960-894x(99)00696-4
		9958732	165991	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsBinding affinity towards human histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	532	9	2	5	4.6	NC(=O)N(O)CCC#Cc1ccc(OCCN2CCN([C@H](c3ccccc3)c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmcl.2004.08.060
		CHEMBL425358	165991	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsBinding affinity towards human histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	532	9	2	5	4.6	NC(=O)N(O)CCC#Cc1ccc(OCCN2CCN([C@H](c3ccccc3)c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmcl.2004.08.060
		127052294	140302	0	None	-15	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid scintillation counting method	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3806079	140302	0	None	-15	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid scintillation counting method	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		168290397	191971	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	770	20	6	8	2.5	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](Cc1ccccc1)C(N)=O)C(C)C	10.1021/acs.jmedchem.2c00125
		CHEMBL5201087	191971	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	770	20	6	8	2.5	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](Cc1ccccc1)C(N)=O)C(C)C	10.1021/acs.jmedchem.2c00125
		44304385	203178	0	None	-61	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	404	11	0	5	4.4	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)OC(C)C)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL64259	203178	0	None	-61	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	404	11	0	5	4.4	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)OC(C)C)CC2)cc1	10.1016/s0960-894x(02)00309-8
		168281536	192881	0	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	369	12	4	5	1.7	Cc1nnc(CCCN/C(N)=N/C(=O)NCCCCCCCCN)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5189006	192881	0	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	369	12	4	5	1.7	Cc1nnc(CCCN/C(N)=N/C(=O)NCCCCCCCCN)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221966	192881	0	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	369	12	4	5	1.7	Cc1nnc(CCCN/C(N)=N/C(=O)NCCCCCCCCN)s1	10.1021/acs.jmedchem.1c00692
		168290397	191971	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	770	20	6	8	2.5	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](Cc1ccccc1)C(N)=O)C(C)C	10.1021/acs.jmedchem.2c00125
		CHEMBL5201087	191971	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	770	20	6	8	2.5	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](Cc1ccccc1)C(N)=O)C(C)C	10.1021/acs.jmedchem.2c00125
		11753159	547	6	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	525	5	1	5	4.7	Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl	10.1016/j.bmcl.2012.08.103
		7679	547	6	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	525	5	1	5	4.7	Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl	10.1016/j.bmcl.2012.08.103
		CHEMBL2158814	547	6	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	525	5	1	5	4.7	Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl	10.1016/j.bmcl.2012.08.103
		68938028	81260	0	None	-6	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	504	8	1	4	5.6	Cc1ccccc1C[C@@H](C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158772	81260	0	None	-6	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	504	8	1	4	5.6	Cc1ccccc1C[C@@H](C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		12001832	81272	0	None	-63	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	522	8	1	4	5.7	Cc1c(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl	10.1016/j.bmcl.2012.08.103
		CHEMBL2158784	81272	0	None	-63	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	522	8	1	4	5.7	Cc1c(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl	10.1016/j.bmcl.2012.08.103
		66615627	81278	0	None	-158	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	536	8	1	4	6.1	Cc1c(OC2CCN(CC3CCN([C@@](C)(Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl	10.1016/j.bmcl.2012.08.103
		CHEMBL2158790	81278	0	None	-158	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	536	8	1	4	6.1	Cc1c(OC2CCN(CC3CCN([C@@](C)(Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl	10.1016/j.bmcl.2012.08.103
		71460419	81310	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	524	8	1	4	5.9	O=C(O)[C@H](Cc1ccc(Cl)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158838	81310	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	524	8	1	4	5.9	O=C(O)[C@H](Cc1ccc(Cl)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		59295939	84213	0	None	-12	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	461	7	3	4	4.1	O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c2ccccc12	10.1016/j.bmcl.2012.09.113
		CHEMBL2208430	84213	0	None	-12	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	461	7	3	4	4.1	O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c2ccccc12	10.1016/j.bmcl.2012.09.113
		1222	881	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor S3.36C mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor S3.36C mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/nchembio714
		2678	881	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor S3.36C mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor S3.36C mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/nchembio714
		581	881	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor S3.36C mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor S3.36C mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/nchembio714
		CHEMBL1000	881	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor S3.36C mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor S3.36C mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/nchembio714
		DB00341	881	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor S3.36C mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor S3.36C mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/nchembio714
		1222	881	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor S3.36T mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor S3.36T mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/nchembio714
		2678	881	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor S3.36T mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor S3.36T mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/nchembio714
		581	881	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor S3.36T mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor S3.36T mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/nchembio714
		CHEMBL1000	881	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor S3.36T mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor S3.36T mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/nchembio714
		DB00341	881	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor S3.36T mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor S3.36T mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/nchembio714
		12660330	154590	3	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	255	7	1	2	3.3	CNCCCOc1ccccc1Cc1ccccc1	10.1021/acs.jmedchem.6b00981
		CHEMBL3964404	154590	3	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	255	7	1	2	3.3	CNCCCOc1ccccc1Cc1ccccc1	10.1021/acs.jmedchem.6b00981
		CHEMBL3991396	154590	3	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	255	7	1	2	3.3	CNCCCOc1ccccc1Cc1ccccc1	10.1021/acs.jmedchem.6b00981
		9888211	21416	13	None	-39	10	Guinea pig	7.5	pKi	=	7.5	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	417	6	1	3	4.5	O=C1c2ccccc2C(=O)N1CCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1	10.1021/jm070516u
		CHEMBL131495	21416	13	None	-39	10	Guinea pig	7.5	pKi	=	7.5	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	417	6	1	3	4.5	O=C1c2ccccc2C(=O)N1CCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1	10.1021/jm070516u
		11753159	547	6	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	525	5	1	5	4.7	Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl	10.1016/j.bmcl.2012.08.124
		7679	547	6	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	525	5	1	5	4.7	Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl	10.1016/j.bmcl.2012.08.124
		CHEMBL2158814	547	6	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	525	5	1	5	4.7	Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl	10.1016/j.bmcl.2012.08.124
		71462390	82245	0	None	6	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	500	5	1	6	4.3	O=C(c1ccc(-c2nn[nH]n2)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.124
		CHEMBL2171026	82245	0	None	6	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	500	5	1	6	4.3	O=C(c1ccc(-c2nn[nH]n2)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.124
		17963315	82252	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	511	5	1	5	4.4	O=C(NS(=O)(=O)c1ccccc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.124
		CHEMBL2171033	82252	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	511	5	1	5	4.4	O=C(NS(=O)(=O)c1ccccc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.124
		71455217	82261	0	None	3	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	525	5	1	5	4.7	Cc1cccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1	10.1016/j.bmcl.2012.08.124
		CHEMBL2171042	82261	0	None	3	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	525	5	1	5	4.7	Cc1cccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1	10.1016/j.bmcl.2012.08.124
		95338888	162526	1	None	1	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	286	5	0	3	4.1	CCCc1nc(CN2CC[C@H](c3ccccc3)C2)cs1	10.1021/acs.jmedchem.8b00718
		CHEMBL4167807	162526	1	None	1	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	286	5	0	3	4.1	CCCc1nc(CN2CC[C@H](c3ccccc3)C2)cs1	10.1021/acs.jmedchem.8b00718
		14554145	30890	0	None	-	1	Rat	5.5	pKi	=	5.5	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	386	0	0	2	4.9	CC(=O)N1CCC(=C2c3cc(Cl)c(Cl)cc3CCc3cccnc32)CC1	10.1021/jm00105a069
		CHEMBL139760	30890	0	None	-	1	Rat	5.5	pKi	=	5.5	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	386	0	0	2	4.9	CC(=O)N1CCC(=C2c3cc(Cl)c(Cl)cc3CCc3cccnc32)CC1	10.1021/jm00105a069
		9549064	98011	3	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity to histamine H1 (unknown origin)Binding affinity to histamine H1 (unknown origin)	ChEMBL	318	5	0	4	3.9	CCCc1ccc2c(c1)sc(=O)n2CCN1CCCCCC1	10.1007/s00044-005-0131-1
		CHEMBL272899	98011	3	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity to histamine H1 (unknown origin)Binding affinity to histamine H1 (unknown origin)	ChEMBL	318	5	0	4	3.9	CCCc1ccc2c(c1)sc(=O)n2CCN1CCCCCC1	10.1007/s00044-005-0131-1
		1605	2342	117	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting method	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1021/jm501086v
		3957	2342	117	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting method	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1021/jm501086v
		7216	2342	117	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting method	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1021/jm501086v
		CHEMBL998	2342	117	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting method	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1021/jm501086v
		DB00455	2342	117	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting method	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1021/jm501086v
		162669496	182595	0	None	-45	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-pyrilamine from human H1 histamine receptor expressed in human HEK293 cellsDisplacement of [3H]-pyrilamine from human H1 histamine receptor expressed in human HEK293 cells	ChEMBL	466	4	0	3	5.1	C[C@H]1CN(CC[C@H]2CC[C@H](N3C(=O)[C@H]4[C@H]5C=C[C@H](C5)[C@H]4C3=O)CC2)CCc2ccc(Cl)cc21	10.1016/j.bmcl.2020.127681
		CHEMBL4788140	182595	0	None	-45	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-pyrilamine from human H1 histamine receptor expressed in human HEK293 cellsDisplacement of [3H]-pyrilamine from human H1 histamine receptor expressed in human HEK293 cells	ChEMBL	466	4	0	3	5.1	C[C@H]1CN(CC[C@H]2CC[C@H](N3C(=O)[C@H]4[C@H]5C=C[C@H](C5)[C@H]4C3=O)CC2)CCc2ccc(Cl)cc21	10.1016/j.bmcl.2020.127681
		122196381	124295	0	None	-295	5	Guinea pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates after 60 mins by liquid scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates after 60 mins by liquid scintillation counting	ChEMBL	485	8	0	6	6.3	Fc1ccc2c(C3CCN(CCCOc4ccc(Cc5nc6ccccc6o5)cc4)CC3)noc2c1	10.1016/j.bmcl.2015.09.045
		CHEMBL3634821	124295	0	None	-295	5	Guinea pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates after 60 mins by liquid scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates after 60 mins by liquid scintillation counting	ChEMBL	485	8	0	6	6.3	Fc1ccc2c(C3CCN(CCCOc4ccc(Cc5nc6ccccc6o5)cc4)CC3)noc2c1	10.1016/j.bmcl.2015.09.045
		71454365	84201	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	465	8	2	6	4.6	O[C@@H](CNC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1)COc1ccc2ncsc2c1	10.1016/j.bmcl.2012.09.113
		CHEMBL2208418	84201	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	465	8	2	6	4.6	O[C@@H](CNC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1)COc1ccc2ncsc2c1	10.1016/j.bmcl.2012.09.113
		17178058	146487	26	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	253	3	1	2	3.5	c1ccc(-c2ccccc2OC2CCNCC2)cc1	10.1021/acs.jmedchem.6b00981
		CHEMBL3922367	146487	26	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	253	3	1	2	3.5	c1ccc(-c2ccccc2OC2CCNCC2)cc1	10.1021/acs.jmedchem.6b00981
		20252868	154482	1	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	241	6	1	2	3.0	NCCCOc1ccccc1Cc1ccccc1	10.1021/acs.jmedchem.6b00981
		CHEMBL3981091	154482	1	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	241	6	1	2	3.0	NCCCOc1ccccc1Cc1ccccc1	10.1021/acs.jmedchem.6b00981
		CHEMBL3990430	154482	1	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	241	6	1	2	3.0	NCCCOc1ccccc1Cc1ccccc1	10.1021/acs.jmedchem.6b00981
		44270793	51343	0	None	-30	2	Guinea pig	5.5	pKi	=	5.5	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	328	6	2	4	2.9	O=C(NN1CCC(c2ccccc2)CC1)OCCCc1c[nH]cn1	10.1021/jm9507688
		CHEMBL15813	51343	0	None	-30	2	Guinea pig	5.5	pKi	=	5.5	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	328	6	2	4	2.9	O=C(NN1CCC(c2ccccc2)CC1)OCCCc1c[nH]cn1	10.1021/jm9507688
		155536080	172114	0	None	-21	10	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-Pyrilamine from human recombinant histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Pyrilamine from human recombinant histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	219	2	1	2	2.9	CC[C@H]1c2cc(OC)ccc2CC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
		CHEMBL4472703	172114	0	None	-21	10	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-Pyrilamine from human recombinant histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Pyrilamine from human recombinant histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	219	2	1	2	2.9	CC[C@H]1c2cc(OC)ccc2CC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
		11723317	102894	0	None	-100	3	Guinea pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]mepyramine bound to membranes of CHO cells expressing guinea pig H1 receptorsDisplacement of [3H]mepyramine bound to membranes of CHO cells expressing guinea pig H1 receptors	ChEMBL	316	9	3	2	2.8	S=C(NCCCCCc1c[nH]cn1)NCCc1ccccc1	10.1021/jm00012a025
		CHEMBL305929	102894	0	None	-100	3	Guinea pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]mepyramine bound to membranes of CHO cells expressing guinea pig H1 receptorsDisplacement of [3H]mepyramine bound to membranes of CHO cells expressing guinea pig H1 receptors	ChEMBL	316	9	3	2	2.8	S=C(NCCCCCc1c[nH]cn1)NCCc1ccccc1	10.1021/jm00012a025
		10015196	103620	0	None	-158	3	Guinea pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]mepyramine bound to membranes of CHO cells expressing guinea pig H1 receptorsDisplacement of [3H]mepyramine bound to membranes of CHO cells expressing guinea pig H1 receptors	ChEMBL	254	8	3	2	2.4	CCC/N=C(\S)NCCCCCc1c[nH]cn1	10.1021/jm00012a025
		CHEMBL308717	103620	0	None	-158	3	Guinea pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]mepyramine bound to membranes of CHO cells expressing guinea pig H1 receptorsDisplacement of [3H]mepyramine bound to membranes of CHO cells expressing guinea pig H1 receptors	ChEMBL	254	8	3	2	2.4	CCC/N=C(\S)NCCCCCc1c[nH]cn1	10.1021/jm00012a025
		10803416	54615	0	None	-1023	2	Guinea pig	4.5	pKi	=	4.5	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	290	6	2	5	2.5	O=C(Nc1ccccc1[N+](=O)[O-])OCCCc1c[nH]cn1	10.1021/jm9507688
		CHEMBL16109	54615	0	None	-1023	2	Guinea pig	4.5	pKi	=	4.5	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	290	6	2	5	2.5	O=C(Nc1ccccc1[N+](=O)[O-])OCCCc1c[nH]cn1	10.1021/jm9507688
		1204	1932	119	None	-501	24	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor N7.45Q mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor N7.45Q mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1038/nchembio714
		1247	1932	119	None	-501	24	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor N7.45Q mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor N7.45Q mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1038/nchembio714
		1375	1932	119	None	-501	24	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor N7.45Q mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor N7.45Q mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1038/nchembio714
		774	1932	119	None	-501	24	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor N7.45Q mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor N7.45Q mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1038/nchembio714
		CHEMBL90	1932	119	None	-501	24	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor N7.45Q mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor N7.45Q mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1038/nchembio714
		DB05381	1932	119	None	-501	24	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor N7.45Q mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor N7.45Q mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1038/nchembio714
		90654502	110311	0	None	-741	2	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	319	9	2	4	1.9	C[C@H](NCc1ccc(OCCCN2CCCCC2)cc1)C(N)=O	10.1016/j.ejmech.2014.03.014
		CHEMBL3238446	110311	0	None	-741	2	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	319	9	2	4	1.9	C[C@H](NCc1ccc(OCCCN2CCCCC2)cc1)C(N)=O	10.1016/j.ejmech.2014.03.014
		53317594	57751	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	318	6	0	4	3.4	C[C@H](C1=C(CCN(C)CC#N)Cc2ccccc21)c1cnccn1	10.1016/j.bmcl.2010.12.053
		CHEMBL1669409	57751	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	318	6	0	4	3.4	C[C@H](C1=C(CCN(C)CC#N)Cc2ccccc21)c1cnccn1	10.1016/j.bmcl.2010.12.053
		155544150	173334	0	None	8	2	Guinea pig	7.5	pKi	=	7.5	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysisDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysis	ChEMBL	316	5	0	3	2.8	CC1CCN(CCCOc2ccc3c(c2)C(=O)N(C)CC3)CC1	10.1016/j.bmcl.2019.04.015
		CHEMBL4526723	173334	0	None	8	2	Guinea pig	7.5	pKi	=	7.5	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysisDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysis	ChEMBL	316	5	0	3	2.8	CC1CCN(CCCOc2ccc3c(c2)C(=O)N(C)CC3)CC1	10.1016/j.bmcl.2019.04.015
		72152555	162730	5	None	1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	345	7	1	5	3.1	Clc1cncc(NCCCCN2CCN(c3ccccc3)CC2)n1	10.1021/acs.jmedchem.8b00718
		CHEMBL4171171	162730	5	None	1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	345	7	1	5	3.1	Clc1cncc(NCCCCN2CCN(c3ccccc3)CC2)n1	10.1021/acs.jmedchem.8b00718
		44326320	112819	0	None	2	3	Human	7.5	pKi	=	7.5	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	295	2	0	3	4.0	CN(C)CC1C[C@H]2c3ccccc3Oc3ccccc3[C@H]2O1	10.1016/j.bmcl.2004.03.069
		CHEMBL330713	112819	0	None	2	3	Human	7.5	pKi	=	7.5	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	295	2	0	3	4.0	CN(C)CC1C[C@H]2c3ccccc3Oc3ccccc3[C@H]2O1	10.1016/j.bmcl.2004.03.069
		1853	3551	38	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.	ChEMBL	352	0	0	2	4.3	Clc1ccc2c(c1)CCc1c(C2=C2CCN(CC2)C(=O)C)nccc1	10.1016/S0960-894X(00)80290-5
		60680	3551	38	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.	ChEMBL	352	0	0	2	4.3	Clc1ccc2c(c1)CCc1c(C2=C2CCN(CC2)C(=O)C)nccc1	10.1016/S0960-894X(00)80290-5
		CHEMBL10971	3551	38	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.	ChEMBL	352	0	0	2	4.3	Clc1ccc2c(c1)CCc1c(C2=C2CCN(CC2)C(=O)C)nccc1	10.1016/S0960-894X(00)80290-5
		1853	3551	38	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	352	0	0	2	4.3	Clc1ccc2c(c1)CCc1c(C2=C2CCN(CC2)C(=O)C)nccc1	10.1016/s0960-894x(98)00626-x
		60680	3551	38	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	352	0	0	2	4.3	Clc1ccc2c(c1)CCc1c(C2=C2CCN(CC2)C(=O)C)nccc1	10.1016/s0960-894x(98)00626-x
		CHEMBL10971	3551	38	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	352	0	0	2	4.3	Clc1ccc2c(c1)CCc1c(C2=C2CCN(CC2)C(=O)C)nccc1	10.1016/s0960-894x(98)00626-x
		1853	3551	38	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	352	0	0	2	4.3	Clc1ccc2c(c1)CCc1c(C2=C2CCN(CC2)C(=O)C)nccc1	10.1021/jm00105a069
		60680	3551	38	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	352	0	0	2	4.3	Clc1ccc2c(c1)CCc1c(C2=C2CCN(CC2)C(=O)C)nccc1	10.1021/jm00105a069
		CHEMBL10971	3551	38	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	352	0	0	2	4.3	Clc1ccc2c(c1)CCc1c(C2=C2CCN(CC2)C(=O)C)nccc1	10.1021/jm00105a069
		45485498	197671	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation counting	ChEMBL	231	5	0	1	3.8	Cc1ccc(CCCCN2CCCCC2)cc1	10.1016/j.bmcl.2009.07.047
		CHEMBL571073	197671	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation counting	ChEMBL	231	5	0	1	3.8	Cc1ccc(CCCCN2CCCCC2)cc1	10.1016/j.bmcl.2009.07.047
		46884062	8359	0	None	-	1	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	296	5	1	3	4.2	CNCCc1sc2ccccc2c1[C@@H](C)c1ccccn1	10.1016/j.bmcl.2010.01.134
		CHEMBL1093044	8359	0	None	-	1	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	296	5	1	3	4.2	CNCCc1sc2ccccc2c1[C@@H](C)c1ccccn1	10.1016/j.bmcl.2010.01.134
		95339542	162030	1	None	-1	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	286	4	0	3	4.3	CC(C)c1nc(CN2CC[C@H](c3ccccc3)C2)cs1	10.1021/acs.jmedchem.8b00718
		CHEMBL4159893	162030	1	None	-1	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	286	4	0	3	4.3	CC(C)c1nc(CN2CC[C@H](c3ccccc3)C2)cs1	10.1021/acs.jmedchem.8b00718
		1353	1911	93	None	-489	83	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		3559	1911	93	None	-489	83	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		86	1911	93	None	-489	83	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		CHEMBL54	1911	93	None	-489	83	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		DB00502	1911	93	None	-489	83	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		44335571	5272	0	None	-128	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	322	6	0	4	3.3	N#Cc1ccc(-c2ccc(OCCCN3CCOCC3)cc2)cc1	10.1016/s0960-894x(02)00648-0
		CHEMBL106483	5272	0	None	-128	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	322	6	0	4	3.3	N#Cc1ccc(-c2ccc(OCCCN3CCOCC3)cc2)cc1	10.1016/s0960-894x(02)00648-0
		40011786	69028	3	None	-32	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	282	2	0	4	2.7	c1ccc2c(N3CCN(C4CCCC4)CC3)ncnc2c1	10.1021/jm2011589
		CHEMBL1923530	69028	3	None	-32	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	282	2	0	4	2.7	c1ccc2c(N3CCN(C4CCCC4)CC3)ncnc2c1	10.1021/jm2011589
		25491778	162665	1	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	378	6	0	5	5.1	CO[C@@H]1CCCN(Cc2nc(-c3cccc(Oc4ccccc4)c3)oc2C)C1	10.1021/acs.jmedchem.8b00718
		CHEMBL4170001	162665	1	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	378	6	0	5	5.1	CO[C@@H]1CCCN(Cc2nc(-c3cccc(Oc4ccccc4)c3)oc2C)C1	10.1021/acs.jmedchem.8b00718
		11023546	78478	0	None	2	4	Rat	7.5	pKi	=	7.5	Binding	Half-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenateHalf-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN([C@H]2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		CHEMBL2111783	78478	0	None	2	4	Rat	7.5	pKi	=	7.5	Binding	Half-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenateHalf-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN([C@H]2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		2389	3331	118	None	-46	67	Human	7.5	pKi	=	7.5	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
		5073	3331	118	None	-46	67	Human	7.5	pKi	=	7.5	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
		96	3331	118	None	-46	67	Human	7.5	pKi	=	7.5	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
		CHEMBL85	3331	118	None	-46	67	Human	7.5	pKi	=	7.5	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
		DB00734	3331	118	None	-46	67	Human	7.5	pKi	=	7.5	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
		44401194	71295	0	None	-4	7	Human	7.5	pKi	=	7.5	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	313	2	0	3	4.1	CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL195706	71295	0	None	-4	7	Human	7.5	pKi	=	7.5	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	313	2	0	3	4.1	CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		56835171	69740	0	None	-204	9	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from mouse H1RDisplacement of [3H]histamine from mouse H1R	ChEMBL	295	2	2	6	1.9	Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935574	69740	0	None	-204	9	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]histamine from mouse H1RDisplacement of [3H]histamine from mouse H1R	ChEMBL	295	2	2	6	1.9	Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1	10.1016/j.bmcl.2011.10.104
		44304412	201648	0	None	-223	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	517	13	1	6	4.9	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@H](NC(=O)OC(C)(C)C)C(C)C)CC2)cc1	10.1016/s0960-894x(02)00310-4
		CHEMBL60598	201648	0	None	-223	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	517	13	1	6	4.9	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@H](NC(=O)OC(C)(C)C)C(C)C)CC2)cc1	10.1016/s0960-894x(02)00310-4
		44304753	203195	0	None	-363	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	466	13	1	6	3.3	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@H](N)Cc3ccncc3)CC2)cc1	10.1016/s0960-894x(02)00310-4
		CHEMBL64321	203195	0	None	-363	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	466	13	1	6	3.3	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@H](N)Cc3ccncc3)CC2)cc1	10.1016/s0960-894x(02)00310-4
		112936267	137295	1	None	2	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	373	6	1	5	3.6	CN1CCN(c2cc(-c3ccccc3)nc(NCCc3ccccc3)n2)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL3752383	137295	1	None	2	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	373	6	1	5	3.6	CN1CCN(c2cc(-c3ccccc3)nc(NCCc3ccccc3)n2)CC1	10.1016/j.bmcl.2015.12.035
		132060776	162402	0	None	-1	16	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-Pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	419	4	0	4	4.4	O=C(OCc1ccccc1)N1CCc2ccc(N3CCN(C4CCCC4)CC3)cc2C1	10.1016/j.ejmech.2018.02.024
		CHEMBL4165863	162402	0	None	-1	16	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-Pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	419	4	0	4	4.4	O=C(OCc1ccccc1)N1CCc2ccc(N3CCN(C4CCCC4)CC3)cc2C1	10.1016/j.ejmech.2018.02.024
		168296769	192332	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	758	20	7	9	0.8	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5206578	192332	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	758	20	7	9	0.8	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		44304256	168019	0	None	-123	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	360	12	0	4	4.2	CCCCCC(=O)c1ccc(OCCCN2CCN(CCC)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL432144	168019	0	None	-123	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	360	12	0	4	4.2	CCCCCC(=O)c1ccc(OCCCN2CCN(CCC)CC2)cc1	10.1016/s0960-894x(02)00309-8
		127035836	137518	0	None	5	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	399	4	1	5	3.9	Cc1ccc(CNc2nc3c(c(N4CCN(C)CC4)n2)CCc2ccccc2-3)cc1	10.1016/j.bmcl.2015.12.035
		CHEMBL3754176	137518	0	None	5	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	399	4	1	5	3.9	Cc1ccc(CNc2nc3c(c(N4CCN(C)CC4)n2)CCc2ccccc2-3)cc1	10.1016/j.bmcl.2015.12.035
		71525678	89725	0	None	-3548	6	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human histamine H1 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H1 receptor expressed in HEK cells	ChEMBL	258	3	2	6	0.6	CCc1cnc2c(N3CC(NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		CHEMBL2376800	89725	0	None	-3548	6	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]histamine from human histamine H1 receptor expressed in HEK cellsDisplacement of [3H]histamine from human histamine H1 receptor expressed in HEK cells	ChEMBL	258	3	2	6	0.6	CCc1cnc2c(N3CC(NC)C3)nc(N)nc2c1	10.1016/j.bmcl.2013.02.091
		129103322	167373	0	None	-53	6	Guinea pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by liquid scintillation countingDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by liquid scintillation counting	ChEMBL	463	6	1	5	4.5	O=C1CCc2cc(C(O)CCCN3CCC(c4noc5cc(F)ccc45)CC3)cc3c2N1CC3	10.1021/acs.jmedchem.8b01096
		CHEMBL4294799	167373	0	None	-53	6	Guinea pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by liquid scintillation countingDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by liquid scintillation counting	ChEMBL	463	6	1	5	4.5	O=C1CCc2cc(C(O)CCCN3CCC(c4noc5cc(F)ccc45)CC3)cc3c2N1CC3	10.1021/acs.jmedchem.8b01096
		168296769	192332	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	758	20	7	9	0.8	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5206578	192332	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	758	20	7	9	0.8	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		2812	4779	101	None	-28	34	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
		CHEMBL104	4779	101	None	-28	34	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
		44335384	4638	0	None	-489	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	334	6	0	3	4.9	CC1CCCCN1CCCOc1ccc(-c2ccc(C#N)cc2)cc1	10.1016/s0960-894x(02)00648-0
		CHEMBL102984	4638	0	None	-489	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	334	6	0	3	4.9	CC1CCCCN1CCCOc1ccc(-c2ccc(C#N)cc2)cc1	10.1016/s0960-894x(02)00648-0
		44304277	100947	0	None	-457	3	Human	4.5	pKi	=	4.5	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	401	10	1	5	2.4	CN[C@@H](C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1)C(C)C	10.1016/s0960-894x(02)00310-4
		CHEMBL294087	100947	0	None	-457	3	Human	4.5	pKi	=	4.5	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	401	10	1	5	2.4	CN[C@@H](C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1)C(C)C	10.1016/s0960-894x(02)00310-4
		46884638	7724	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	293	5	0	3	3.3	Cc1cnc(CC2=C(CCN(C)C)Cc3ccccc32)cn1	10.1016/j.bmcl.2010.02.055
		CHEMBL1088899	7724	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	293	5	0	3	3.3	Cc1cnc(CC2=C(CCN(C)C)Cc3ccccc32)cn1	10.1016/j.bmcl.2010.02.055
		155566038	175742	0	None	26	2	Guinea pig	7.5	pKi	=	7.5	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysisDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysis	ChEMBL	318	5	1	4	1.5	CN1CCc2ccc(OCCCN3CCC(O)CC3)cc2C1=O	10.1016/j.bmcl.2019.04.015
		CHEMBL4583183	175742	0	None	26	2	Guinea pig	7.5	pKi	=	7.5	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysisDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysis	ChEMBL	318	5	1	4	1.5	CN1CCc2ccc(OCCCN3CCC(O)CC3)cc2C1=O	10.1016/j.bmcl.2019.04.015
		51111982	162578	6	None	1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	344	5	0	4	3.2	N#Cc1c(CN2CCN(CCc3ccccc3)CC2)cn2ccccc12	10.1021/acs.jmedchem.8b00718
		CHEMBL4168691	162578	6	None	1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	344	5	0	4	3.2	N#Cc1c(CN2CCN(CCc3ccccc3)CC2)cn2ccccc12	10.1021/acs.jmedchem.8b00718
		11623845	8323	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	316	5	0	4	4.6	CC(c1nccs1)c1c(CCN(C)C)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		CHEMBL1092767	8323	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	316	5	0	4	4.6	CC(c1nccs1)c1c(CCN(C)C)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		1605	2342	117	None	-2	4	Rat	6.5	pKi	=	6.5	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1021/jm00105a069
		3957	2342	117	None	-2	4	Rat	6.5	pKi	=	6.5	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1021/jm00105a069
		7216	2342	117	None	-2	4	Rat	6.5	pKi	=	6.5	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1021/jm00105a069
		CHEMBL998	2342	117	None	-2	4	Rat	6.5	pKi	=	6.5	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1021/jm00105a069
		DB00455	2342	117	None	-2	4	Rat	6.5	pKi	=	6.5	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1021/jm00105a069
		CHEMBL5274312	193809	0	None	-3	5	Human	5.5	pKi	=	5.5	Binding	Binding affinity to histamine H1 receptor (unknown origin)Binding affinity to histamine H1 receptor (unknown origin)	ChEMBL	383	4	0	3	5.0	CC[Si](C#Cc1cccc2c1OC(C(F)(F)F)C([N+](=O)[O-])=C2)(CC)CC	10.1016/j.bmcl.2022.128981
		44335351	5067	0	None	-1	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity at human cortical Histamine 1 receptorBinding affinity at human cortical Histamine 1 receptor	ChEMBL	402	7	0	4	4.6	CCOC(=O)N1CCN(CCCOc2ccc(-c3ccc(Cl)cc3)cc2)CC1	10.1016/s0960-894x(02)00648-0
		CHEMBL105385	5067	0	None	-1	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity at human cortical Histamine 1 receptorBinding affinity at human cortical Histamine 1 receptor	ChEMBL	402	7	0	4	4.6	CCOC(=O)N1CCN(CCCOc2ccc(-c3ccc(Cl)cc3)cc2)CC1	10.1016/s0960-894x(02)00648-0
		44304021	102795	0	None	-9	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	374	8	0	5	3.4	CCOC(=O)N1CCN(CCCOc2ccc(C(=O)C=C(C)C)cc2)CC1	10.1016/s0960-894x(02)00309-8
		CHEMBL305313	102795	0	None	-9	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	374	8	0	5	3.4	CCOC(=O)N1CCN(CCCOc2ccc(C(=O)C=C(C)C)cc2)CC1	10.1016/s0960-894x(02)00309-8
		10069595	203128	0	None	-112	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	400	11	0	4	4.2	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)C3CCC3)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL64100	203128	0	None	-112	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	400	11	0	4	4.2	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)C3CCC3)CC2)cc1	10.1016/s0960-894x(02)00309-8
		44335350	5080	0	None	-1	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	398	8	0	5	3.9	CCOC(=O)N1CCN(CCCOc2ccc(-c3ccc(OC)cc3)cc2)CC1	10.1016/s0960-894x(02)00648-0
		CHEMBL105483	5080	0	None	-1	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	398	8	0	5	3.9	CCOC(=O)N1CCN(CCCOc2ccc(-c3ccc(OC)cc3)cc2)CC1	10.1016/s0960-894x(02)00648-0
		44335336	4558	0	None	-27	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human cortical Histamine 1 receptorBinding affinity at human cortical Histamine 1 receptor	ChEMBL	335	6	1	4	3.4	N#Cc1ccc(-c2ccc(OCCCN3CCC(N)CC3)cc2)cc1	10.1016/s0960-894x(02)00648-0
		CHEMBL102452	4558	0	None	-27	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human cortical Histamine 1 receptorBinding affinity at human cortical Histamine 1 receptor	ChEMBL	335	6	1	4	3.4	N#Cc1ccc(-c2ccc(OCCCN3CCC(N)CC3)cc2)cc1	10.1016/s0960-894x(02)00648-0
		25109291	191386	10	None	-83176	8	Human	5.5	pKi	=	5.5	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	327	1	2	6	1.7	Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1	10.1021/jm8007618
		CHEMBL519240	191386	10	None	-83176	8	Human	5.5	pKi	=	5.5	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	327	1	2	6	1.7	Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1	10.1021/jm8007618
		168273640	192805	0	None	-100	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	568	15	8	10	-0.1	N/C(=N\C(=O)NCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5176229	192805	0	None	-100	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	568	15	8	10	-0.1	N/C(=N\C(=O)NCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221444	192805	0	None	-100	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	568	15	8	10	-0.1	N/C(=N\C(=O)NCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		44304012	202832	0	None	-18620	3	Human	4.5	pKi	=	4.5	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	389	11	1	5	2.7	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@@H](C)N)CC2)cc1	10.1016/s0960-894x(02)00310-4
		CHEMBL62421	202832	0	None	-18620	3	Human	4.5	pKi	=	4.5	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	389	11	1	5	2.7	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@@H](C)N)CC2)cc1	10.1016/s0960-894x(02)00310-4
		44289035	100514	0	None	-186	7	Human	6.5	pKi	=	6.5	Binding	Selectivity screen against human Histamine H1 receptorSelectivity screen against human Histamine H1 receptor	ChEMBL	524	7	1	4	4.4	CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C	10.1016/s0960-894x(99)00696-4
		CHEMBL291166	100514	0	None	-186	7	Human	6.5	pKi	=	6.5	Binding	Selectivity screen against human Histamine H1 receptorSelectivity screen against human Histamine H1 receptor	ChEMBL	524	7	1	4	4.4	CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C	10.1016/s0960-894x(99)00696-4
		50985821	176218	31	None	-2	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity to H1 receptor (unknown origin) by radioligand displacement assayBinding affinity to H1 receptor (unknown origin) by radioligand displacement assay	ChEMBL	474	5	2	5	6.2	N=c1c2c(-c3ccccc3)c(-c3ccccc3)n(Cc3ccccc3)c2ncn1[C@H]1CC[C@H](O)CC1	10.1021/acs.jmedchem.2c00204
		CHEMBL4594433	176218	31	None	-2	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity to H1 receptor (unknown origin) by radioligand displacement assayBinding affinity to H1 receptor (unknown origin) by radioligand displacement assay	ChEMBL	474	5	2	5	6.2	N=c1c2c(-c3ccccc3)c(-c3ccccc3)n(Cc3ccccc3)c2ncn1[C@H]1CC[C@H](O)CC1	10.1021/acs.jmedchem.2c00204
		44343572	10286	0	None	-	1	Rat	5.4	pKi	=	5.4	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	383	3	0	3	3.9	CCCC(=O)N1CCN(C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/s0960-894x(98)00626-x
		CHEMBL116144	10286	0	None	-	1	Rat	5.4	pKi	=	5.4	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	383	3	0	3	3.9	CCCC(=O)N1CCN(C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/s0960-894x(98)00626-x
		71457970	78470	0	None	-	1	Rat	5.4	pKi	=	5.4	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	355	1	0	3	3.1	CC(=O)N1CCN([C@@H]2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/s0960-894x(98)00626-x
		CHEMBL2111767	78470	0	None	-	1	Rat	5.4	pKi	=	5.4	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	355	1	0	3	3.1	CC(=O)N1CCN([C@@H]2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/s0960-894x(98)00626-x
		19918406	111359	0	None	-	1	Rat	5.4	pKi	=	5.4	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	367	1	0	3	3.2	O=C1CCC2CN(C3c4ccc(Cl)cc4CCc4cccnc43)CCN12	10.1016/s0960-894x(98)00626-x
		CHEMBL326978	111359	0	None	-	1	Rat	5.4	pKi	=	5.4	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	367	1	0	3	3.2	O=C1CCC2CN(C3c4ccc(Cl)cc4CCc4cccnc43)CCN12	10.1016/s0960-894x(98)00626-x
		11848625	5792	0	None	-38	6	Human	5.4	pKi	=	5.4	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	451	8	1	7	4.9	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)cc(OC2CCOCC2)c1	10.1016/j.bmcl.2009.09.024
		CHEMBL1078745	5792	0	None	-38	6	Human	5.4	pKi	=	5.4	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	451	8	1	7	4.9	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)cc(OC2CCOCC2)c1	10.1016/j.bmcl.2009.09.024
		44334407	109085	0	None	-1202	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	462	10	1	5	3.8	O=C(c1ccc(OCCCN2CC[C@H](NS(=O)(=O)c3cccc(Cl)c3)C2)cc1)C1CC1	10.1016/s0960-894x(02)00685-6
		CHEMBL321320	109085	0	None	-1202	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	462	10	1	5	3.8	O=C(c1ccc(OCCCN2CC[C@H](NS(=O)(=O)c3cccc(Cl)c3)C2)cc1)C1CC1	10.1016/s0960-894x(02)00685-6
		56835171	69740	0	None	-223	9	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from rat H1RDisplacement of [3H]histamine from rat H1R	ChEMBL	295	2	2	6	1.9	Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935574	69740	0	None	-223	9	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]histamine from rat H1RDisplacement of [3H]histamine from rat H1R	ChEMBL	295	2	2	6	1.9	Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1	10.1016/j.bmcl.2011.10.104
		127052465	140731	0	None	-97	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	340	5	0	3	3.6	O=C1c2ccccc2C(=O)N1CCCCN1CCC2CCCCC2C1	10.1016/j.bmc.2016.05.053
		CHEMBL3817911	140731	0	None	-97	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	340	5	0	3	3.6	O=C1c2ccccc2C(=O)N1CCCCN1CCC2CCCCC2C1	10.1016/j.bmc.2016.05.053
		127052465	140731	0	None	-97	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	340	5	0	3	3.6	O=C1c2ccccc2C(=O)N1CCCCN1CCC2CCCCC2C1	10.1016/j.bmc.2016.05.053
		CHEMBL3817911	140731	0	None	-97	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	340	5	0	3	3.6	O=C1c2ccccc2C(=O)N1CCCCN1CCC2CCCCC2C1	10.1016/j.bmc.2016.05.053
		162662563	182046	0	None	-61	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cell membranes co-expressing RGS4 measured after 60 mins by scintillation counting analysisDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cell membranes co-expressing RGS4 measured after 60 mins by scintillation counting analysis	ChEMBL	391	7	0	4	4.5	Fc1ccc(-c2ccc(OCCCN3CCN(c4ccncc4)CC3)cc2)cc1	10.1016/j.ejmech.2020.113041
		CHEMBL4781093	182046	0	None	-61	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cell membranes co-expressing RGS4 measured after 60 mins by scintillation counting analysisDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cell membranes co-expressing RGS4 measured after 60 mins by scintillation counting analysis	ChEMBL	391	7	0	4	4.5	Fc1ccc(-c2ccc(OCCCN3CCN(c4ccncc4)CC3)cc2)cc1	10.1016/j.ejmech.2020.113041
		1605	2342	117	None	-2	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity for H1 histamine receptor expressed in CHO cellsBinding affinity for H1 histamine receptor expressed in CHO cells	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1021/jm049495j
		3957	2342	117	None	-2	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity for H1 histamine receptor expressed in CHO cellsBinding affinity for H1 histamine receptor expressed in CHO cells	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1021/jm049495j
		7216	2342	117	None	-2	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity for H1 histamine receptor expressed in CHO cellsBinding affinity for H1 histamine receptor expressed in CHO cells	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1021/jm049495j
		CHEMBL998	2342	117	None	-2	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity for H1 histamine receptor expressed in CHO cellsBinding affinity for H1 histamine receptor expressed in CHO cells	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1021/jm049495j
		DB00455	2342	117	None	-2	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity for H1 histamine receptor expressed in CHO cellsBinding affinity for H1 histamine receptor expressed in CHO cells	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1021/jm049495j
		10660	14416	58	None	2	12	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
		CHEMBL1200406	14416	58	None	2	12	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
		44343938	113063	0	None	-	1	Rat	5.4	pKi	=	5.4	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	320	1	0	2	3.0	CC(=O)N1CCN(C2c3ccccc3CCc3ccccc32)CC1	10.1016/s0960-894x(98)00626-x
		CHEMBL331159	113063	0	None	-	1	Rat	5.4	pKi	=	5.4	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	320	1	0	2	3.0	CC(=O)N1CCN(C2c3ccccc3CCc3ccccc32)CC1	10.1016/s0960-894x(98)00626-x
		44334035	110045	0	None	-741	3	Human	4.4	pKi	=	4.4	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	476	10	1	7	4.1	O=C(N[C@H]1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)C1)c1csc(-c2cccnc2)n1	10.1016/s0960-894x(02)00685-6
		CHEMBL323517	110045	0	None	-741	3	Human	4.4	pKi	=	4.4	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	476	10	1	7	4.1	O=C(N[C@H]1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)C1)c1csc(-c2cccnc2)n1	10.1016/s0960-894x(02)00685-6
		2771	195017	74	None	-2	27	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	nan
		CHEMBL1200781	195017	74	None	-2	27	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	nan
		CHEMBL549	195017	74	None	-2	27	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	nan
		168277300	190180	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	754	19	5	7	3.5	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O)C(C)C	10.1021/acs.jmedchem.2c00125
		CHEMBL5174142	190180	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	754	19	5	7	3.5	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O)C(C)C	10.1021/acs.jmedchem.2c00125
		10268636	5283	0	None	-436	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	335	7	1	4	3.3	CN[C@@H]1CCN(CCCOc2ccc(-c3ccc(C#N)cc3)cc2)C1	10.1016/s0960-894x(02)00648-0
		CHEMBL106545	5283	0	None	-436	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	335	7	1	4	3.3	CN[C@@H]1CCN(CCCOc2ccc(-c3ccc(C#N)cc3)cc2)C1	10.1016/s0960-894x(02)00648-0
		44335222	163456	0	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	369	7	0	5	3.3	CCOC(=O)N1CCN(CCCOc2ccc(-c3ccncc3)cc2)CC1	10.1016/s0960-894x(02)00648-0
		CHEMBL419912	163456	0	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	369	7	0	5	3.3	CCOC(=O)N1CCN(CCCOc2ccc(-c3ccncc3)cc2)CC1	10.1016/s0960-894x(02)00648-0
		168294166	193014	0	None	-1	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	360	6	4	4	3.3	CCCCCNC(=O)/N=C(\N)Nc1ccc(-c2sc(N)nc2C)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5209081	193014	0	None	-1	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	360	6	4	4	3.3	CCCCCNC(=O)/N=C(\N)Nc1ccc(-c2sc(N)nc2C)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222775	193014	0	None	-1	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	360	6	4	4	3.3	CCCCCNC(=O)/N=C(\N)Nc1ccc(-c2sc(N)nc2C)cc1	10.1021/acs.jmedchem.1c00692
		44304329	203227	0	None	-1230	3	Human	4.4	pKi	=	4.4	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	385	8	1	5	1.9	O=C(c1ccc(OCCCN2CCN(C(=O)[C@H]3CCCN3)CC2)cc1)C1CC1	10.1016/s0960-894x(02)00310-4
		CHEMBL64461	203227	0	None	-1230	3	Human	4.4	pKi	=	4.4	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	385	8	1	5	1.9	O=C(c1ccc(OCCCN2CCN(C(=O)[C@H]3CCCN3)CC2)cc1)C1CC1	10.1016/s0960-894x(02)00310-4
		168277300	190180	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	754	19	5	7	3.5	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O)C(C)C	10.1021/acs.jmedchem.2c00125
		CHEMBL5174142	190180	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	754	19	5	7	3.5	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O)C(C)C	10.1021/acs.jmedchem.2c00125
		71450550	83807	0	None	-7	16	Human	5.4	pKi	=	5.4	Binding	Binding affinity to Histamine H1 receptorBinding affinity to Histamine H1 receptor	ChEMBL	309	4	1	3	2.0	COc1ccccc1CCN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
		CHEMBL2205836	83807	0	None	-7	16	Human	5.4	pKi	=	5.4	Binding	Binding affinity to Histamine H1 receptorBinding affinity to Histamine H1 receptor	ChEMBL	309	4	1	3	2.0	COc1ccccc1CCN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
		44455426	155149	0	None	-5	12	Human	6.4	pKi	=	6.4	Binding	Inhibition of human cloned histamine H1 receptor by competitive binding experimentInhibition of human cloned histamine H1 receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		CHEMBL402143	155149	0	None	-5	12	Human	6.4	pKi	=	6.4	Binding	Inhibition of human cloned histamine H1 receptor by competitive binding experimentInhibition of human cloned histamine H1 receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		9894665	103813	1	None	-114	8	Guinea pig	7.4	pKi	=	7.4	Binding	Binding affinity towards histamine H1 receptor was determined in guinea pig brain using [3H]pyrilamine as radioligandBinding affinity towards histamine H1 receptor was determined in guinea pig brain using [3H]pyrilamine as radioligand	ChEMBL	585	10	2	8	3.3	CC(C)Oc1ccccc1N1CCN(C[C@@H](O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(N(C)C)cc2)C3=O)CC1	10.1021/jm9905918
		CHEMBL309106	103813	1	None	-114	8	Guinea pig	7.4	pKi	=	7.4	Binding	Binding affinity towards histamine H1 receptor was determined in guinea pig brain using [3H]pyrilamine as radioligandBinding affinity towards histamine H1 receptor was determined in guinea pig brain using [3H]pyrilamine as radioligand	ChEMBL	585	10	2	8	3.3	CC(C)Oc1ccccc1N1CCN(C[C@@H](O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(N(C)C)cc2)C3=O)CC1	10.1021/jm9905918
		46884119	8150	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	328	5	0	3	4.7	CC(c1cccc(F)n1)c1c(CCN(C)C)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		CHEMBL1091793	8150	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	328	5	0	3	4.7	CC(c1cccc(F)n1)c1c(CCN(C)C)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		57334404	90512	0	None	-3	5	Guinea pig	7.4	pKi	=	7.4	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysisDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysis	ChEMBL	512	8	0	6	6.8	O=c1cc(-c2ccccc2)c2ccc(OCCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2o1	10.1021/jm400408r
		CHEMBL2387265	90512	0	None	-3	5	Guinea pig	7.4	pKi	=	7.4	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysisDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysis	ChEMBL	512	8	0	6	6.8	O=c1cc(-c2ccccc2)c2ccc(OCCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2o1	10.1021/jm400408r
		2389	3331	118	None	-52	67	Guinea pig	7.4	pKi	=	7.4	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates after 60 mins by liquid scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates after 60 mins by liquid scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2015.09.045
		5073	3331	118	None	-52	67	Guinea pig	7.4	pKi	=	7.4	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates after 60 mins by liquid scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates after 60 mins by liquid scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2015.09.045
		96	3331	118	None	-52	67	Guinea pig	7.4	pKi	=	7.4	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates after 60 mins by liquid scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates after 60 mins by liquid scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2015.09.045
		CHEMBL85	3331	118	None	-52	67	Guinea pig	7.4	pKi	=	7.4	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates after 60 mins by liquid scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates after 60 mins by liquid scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2015.09.045
		DB00734	3331	118	None	-52	67	Guinea pig	7.4	pKi	=	7.4	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates after 60 mins by liquid scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates after 60 mins by liquid scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2015.09.045
		44335368	5050	0	None	2	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity at human cortical Histamine 1 receptorBinding affinity at human cortical Histamine 1 receptor	ChEMBL	393	7	0	5	3.8	CCOC(=O)N1CCN(CCCOc2ccc(-c3cccc(C#N)c3)cc2)CC1	10.1016/s0960-894x(02)00648-0
		CHEMBL105268	5050	0	None	2	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity at human cortical Histamine 1 receptorBinding affinity at human cortical Histamine 1 receptor	ChEMBL	393	7	0	5	3.8	CCOC(=O)N1CCN(CCCOc2ccc(-c3cccc(C#N)c3)cc2)CC1	10.1016/s0960-894x(02)00648-0
		44304282	203113	0	None	-1	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	410	8	0	5	3.8	CCOC(=O)N1CCN(CCCOc2ccc(C(=O)c3cccc(C)c3)cc2)CC1	10.1016/s0960-894x(02)00309-8
		CHEMBL64021	203113	0	None	-1	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	410	8	0	5	3.8	CCOC(=O)N1CCN(CCCOc2ccc(C(=O)c3cccc(C)c3)cc2)CC1	10.1016/s0960-894x(02)00309-8
		11808247	18075	0	None	-4	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	285	5	0	2	3.7	Fc1ccc(OCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL126667	18075	0	None	-4	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	285	5	0	2	3.7	Fc1ccc(OCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3819366	18075	0	None	-4	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	285	5	0	2	3.7	Fc1ccc(OCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		127052294	140302	0	None	-15	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid scintillation counting method	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3806079	140302	0	None	-15	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid scintillation counting method	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		164610892	185198	0	None	-53	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	394	8	4	4	3.2	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)CC1CCCCC1	10.1016/j.ejmech.2021.113190
		CHEMBL4857560	185198	0	None	-53	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	394	8	4	4	3.2	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)CC1CCCCC1	10.1016/j.ejmech.2021.113190
		11808247	18075	0	None	-4	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	285	5	0	2	3.7	Fc1ccc(OCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL126667	18075	0	None	-4	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	285	5	0	2	3.7	Fc1ccc(OCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3819366	18075	0	None	-4	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	285	5	0	2	3.7	Fc1ccc(OCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		71452382	83794	0	None	-120	10	Human	5.4	pKi	=	5.4	Binding	Binding affinity to Histamine H1 receptorBinding affinity to Histamine H1 receptor	ChEMBL	309	4	1	3	2.0	COc1ccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1	10.1016/j.bmcl.2012.08.046
		CHEMBL2205812	83794	0	None	-120	10	Human	5.4	pKi	=	5.4	Binding	Binding affinity to Histamine H1 receptorBinding affinity to Histamine H1 receptor	ChEMBL	309	4	1	3	2.0	COc1ccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1	10.1016/j.bmcl.2012.08.046
		1353	1911	93	None	-602	83	Rat	6.4	pKi	=	6.4	Binding	Half-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenateHalf-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenate	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm010982y
		3559	1911	93	None	-602	83	Rat	6.4	pKi	=	6.4	Binding	Half-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenateHalf-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenate	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm010982y
		86	1911	93	None	-602	83	Rat	6.4	pKi	=	6.4	Binding	Half-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenateHalf-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenate	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm010982y
		CHEMBL54	1911	93	None	-602	83	Rat	6.4	pKi	=	6.4	Binding	Half-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenateHalf-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenate	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm010982y
		DB00502	1911	93	None	-602	83	Rat	6.4	pKi	=	6.4	Binding	Half-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenateHalf-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenate	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm010982y
		1353	1911	93	None	-602	83	Rat	6.4	pKi	=	6.4	Binding	In vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamineIn vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamine	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm0309811
		3559	1911	93	None	-602	83	Rat	6.4	pKi	=	6.4	Binding	In vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamineIn vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamine	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm0309811
		86	1911	93	None	-602	83	Rat	6.4	pKi	=	6.4	Binding	In vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamineIn vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamine	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm0309811
		CHEMBL54	1911	93	None	-602	83	Rat	6.4	pKi	=	6.4	Binding	In vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamineIn vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamine	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm0309811
		DB00502	1911	93	None	-602	83	Rat	6.4	pKi	=	6.4	Binding	In vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamineIn vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamine	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm0309811
		46882224	6348	0	None	-354	5	Human	4.4	pKi	=	4.4	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	543	10	1	9	4.7	CCOc1cc(CN2CCC(Nc3nc4cc(S(=O)(=O)CC)ccc4o3)CC2)cc(OC2CCOCC2)c1	10.1016/j.bmcl.2009.09.024
		CHEMBL1082036	6348	0	None	-354	5	Human	4.4	pKi	=	4.4	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	543	10	1	9	4.7	CCOc1cc(CN2CCC(Nc3nc4cc(S(=O)(=O)CC)ccc4o3)CC2)cc(OC2CCOCC2)c1	10.1016/j.bmcl.2009.09.024
		20293994	199815	8	None	1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cellsDisplacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cells	ChEMBL	239	6	1	1	3.8	CNCCCC(c1ccccc1)c1ccccc1	10.1016/j.bmc.2009.08.016
		CHEMBL594138	199815	8	None	1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cellsDisplacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cells	ChEMBL	239	6	1	1	3.8	CNCCCC(c1ccccc1)c1ccccc1	10.1016/j.bmc.2009.08.016
		11393516	5172	0	None	-467	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	335	6	1	4	3.3	N#Cc1ccc(-c2ccc(OCCCN3CCCNCC3)cc2)cc1	10.1016/s0960-894x(02)00648-0
		CHEMBL105967	5172	0	None	-467	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	335	6	1	4	3.3	N#Cc1ccc(-c2ccc(OCCCN3CCCNCC3)cc2)cc1	10.1016/s0960-894x(02)00648-0
		69355600	78685	0	None	-954	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	336	6	1	4	3.5	C[C@@]1(O)CCN(CCCOc2ccc(-c3ccc(C#N)cc3)cc2)C1	10.1016/s0960-894x(02)00648-0
		CHEMBL2112461	78685	0	None	-954	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	336	6	1	4	3.5	C[C@@]1(O)CCN(CCCOc2ccc(-c3ccc(C#N)cc3)cc2)C1	10.1016/s0960-894x(02)00648-0
		168278543	192851	0	None	-2	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	358	4	4	4	1.6	N/C(=N\C(=O)NCc1ccccc1)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		CHEMBL5184846	192851	0	None	-2	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	358	4	4	4	1.6	N/C(=N\C(=O)NCc1ccccc1)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221764	192851	0	None	-2	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	358	4	4	4	1.6	N/C(=N\C(=O)NCc1ccccc1)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		168284289	192906	0	None	-3	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	428	8	4	4	3.1	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		CHEMBL5194860	192906	0	None	-3	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	428	8	4	4	3.1	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222123	192906	0	None	-3	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	428	8	4	4	3.1	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		44301729	200942	0	None	-1	2	Rat	7.4	pKi	=	7.4	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	ChEMBL	382	11	2	3	5.0	Clc1ccc(C(CCNCCCCCc2c[nH]cn2)c2ccccn2)cc1	10.1016/s0960-894x(03)00357-3
		CHEMBL60175	200942	0	None	-1	2	Rat	7.4	pKi	=	7.4	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	ChEMBL	382	11	2	3	5.0	Clc1ccc(C(CCNCCCCCc2c[nH]cn2)c2ccccn2)cc1	10.1016/s0960-894x(03)00357-3
		141485892	170978	0	None	4	2	Guinea pig	7.4	pKi	=	7.4	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysisDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysis	ChEMBL	288	5	0	3	2.2	CN1CCc2ccc(OCCCN3CCCC3)cc2C1=O	10.1016/j.bmcl.2019.04.015
		CHEMBL4456092	170978	0	None	4	2	Guinea pig	7.4	pKi	=	7.4	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysisDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysis	ChEMBL	288	5	0	3	2.2	CN1CCc2ccc(OCCCN3CCCC3)cc2C1=O	10.1016/j.bmcl.2019.04.015
		44622872	197716	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation counting	ChEMBL	413	8	1	2	6.0	Cc1ccc(CCCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1	10.1016/j.bmcl.2009.07.047
		CHEMBL571389	197716	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation counting	ChEMBL	413	8	1	2	6.0	Cc1ccc(CCCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1	10.1016/j.bmcl.2009.07.047
		66615619	81271	0	None	-79	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	522	8	1	4	5.7	Cc1c(Cl)ccc(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)c1Cl	10.1016/j.bmcl.2012.08.103
		CHEMBL2158783	81271	0	None	-79	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	522	8	1	4	5.7	Cc1c(Cl)ccc(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)c1Cl	10.1016/j.bmcl.2012.08.103
		71462103	81302	1	None	2	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	492	8	1	5	5.2	O=C(O)COc1ccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158830	81302	1	None	2	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	492	8	1	5	5.2	O=C(O)COc1ccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1	10.1016/j.bmcl.2012.08.103
		59296099	84090	0	None	-50	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	494	7	3	5	3.7	Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]nc3C(F)(F)F)CC2)c1Cl	10.1016/j.bmcl.2012.09.112
		CHEMBL2207660	84090	0	None	-50	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	494	7	3	5	3.7	Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]nc3C(F)(F)F)CC2)c1Cl	10.1016/j.bmcl.2012.09.112
		2337	3256	77	None	-1	62	Guinea pig	7.4	pKi	=	7.4	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm070516u
		50	3256	77	None	-1	62	Guinea pig	7.4	pKi	=	7.4	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm070516u
		5002	3256	77	None	-1	62	Guinea pig	7.4	pKi	=	7.4	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm070516u
		CHEMBL716	3256	77	None	-1	62	Guinea pig	7.4	pKi	=	7.4	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm070516u
		DB01224	3256	77	None	-1	62	Guinea pig	7.4	pKi	=	7.4	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm070516u
		71449859	82248	0	None	10	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	600	10	1	8	5.1	O=C(O)CCCCn1nnc(-c2ccc(C(=O)N3CCC(N4CCC(Oc5ccc(Cl)c(Cl)c5)CC4)CC3)cc2)n1	10.1016/j.bmcl.2012.08.124
		CHEMBL2171029	82248	0	None	10	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	600	10	1	8	5.1	O=C(O)CCCCn1nnc(-c2ccc(C(=O)N3CCC(N4CCC(Oc5ccc(Cl)c(Cl)c5)CC4)CC3)cc2)n1	10.1016/j.bmcl.2012.08.124
		17963347	82264	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	579	5	1	5	5.4	O=C(NS(=O)(=O)c1cccc(C(F)(F)F)c1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.124
		CHEMBL2171045	82264	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	579	5	1	5	5.4	O=C(NS(=O)(=O)c1cccc(C(F)(F)F)c1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.124
		11702578	8148	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	324	5	0	3	4.9	Cc1ccnc(C(C)c2c(CCN(C)C)sc3ccccc23)c1	10.1016/j.bmcl.2010.01.134
		CHEMBL1091791	8148	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	324	5	0	3	4.9	Cc1ccnc(C(C)c2c(CCN(C)C)sc3ccccc23)c1	10.1016/j.bmcl.2010.01.134
		25212275	174421	0	None	-9332	6	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	682	13	0	8	7.4	O=C(OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1)c1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
		CHEMBL455288	174421	0	None	-9332	6	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	682	13	0	8	7.4	O=C(OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1)c1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
		10436842	100256	0	None	-501	7	Human	6.4	pKi	=	6.4	Binding	Selectivity screen against human Histamine H1 receptorSelectivity screen against human Histamine H1 receptor	ChEMBL	524	7	1	4	4.6	CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C	10.1016/s0960-894x(99)00696-4
		CHEMBL288772	100256	0	None	-501	7	Human	6.4	pKi	=	6.4	Binding	Selectivity screen against human Histamine H1 receptorSelectivity screen against human Histamine H1 receptor	ChEMBL	524	7	1	4	4.6	CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C	10.1016/s0960-894x(99)00696-4
		44304247	202809	0	None	-38	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	412	11	0	5	4.3	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3ccco3)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL62312	202809	0	None	-38	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	412	11	0	5	4.3	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3ccco3)CC2)cc1	10.1016/s0960-894x(02)00309-8
		71451390	81266	0	None	-7	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	474	8	1	4	4.7	O=C(O)[C@H](Cc1ccc(F)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158778	81266	0	None	-7	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	474	8	1	4	4.7	O=C(O)[C@H](Cc1ccc(F)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		1353	1911	93	None	-213	83	Guinea pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm070516u
		3559	1911	93	None	-213	83	Guinea pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm070516u
		86	1911	93	None	-213	83	Guinea pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm070516u
		CHEMBL54	1911	93	None	-213	83	Guinea pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm070516u
		DB00502	1911	93	None	-213	83	Guinea pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm070516u
		44304291	202852	0	None	-891	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	388	11	0	4	4.0	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)C(C)C)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL62527	202852	0	None	-891	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	388	11	0	4	4.0	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)C(C)C)CC2)cc1	10.1016/s0960-894x(02)00309-8
		44335238	5089	0	None	-1862	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	348	6	0	3	5.3	CC1CCCC(C)N1CCCOc1ccc(-c2ccc(C#N)cc2)cc1	10.1016/s0960-894x(02)00648-0
		CHEMBL105515	5089	0	None	-1862	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	348	6	0	3	5.3	CC1CCCC(C)N1CCCOc1ccc(-c2ccc(C#N)cc2)cc1	10.1016/s0960-894x(02)00648-0
		168294182	193048	0	None	-57	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	314	6	4	2	1.7	C[C@@H](NC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5208722	193048	0	None	-57	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	314	6	4	2	1.7	C[C@@H](NC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222960	193048	0	None	-57	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	314	6	4	2	1.7	C[C@@H](NC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		10017820	204195	0	None	-199	3	Guinea pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]mepyramine bound to membranes of CHO cells expressing guinea pig H1 receptorsDisplacement of [3H]mepyramine bound to membranes of CHO cells expressing guinea pig H1 receptors	ChEMBL	302	8	3	2	2.8	S=C(NCCCCCc1c[nH]cn1)NCc1ccccc1	10.1021/jm00012a025
		CHEMBL70811	204195	0	None	-199	3	Guinea pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]mepyramine bound to membranes of CHO cells expressing guinea pig H1 receptorsDisplacement of [3H]mepyramine bound to membranes of CHO cells expressing guinea pig H1 receptors	ChEMBL	302	8	3	2	2.8	S=C(NCCCCCc1c[nH]cn1)NCc1ccccc1	10.1021/jm00012a025
		18878	144203	90	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	177	2	1	2	1.8	c1ccc(OC2CCNCC2)cc1	10.1021/acs.jmedchem.6b00981
		CHEMBL3904359	144203	90	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	177	2	1	2	1.8	c1ccc(OC2CCNCC2)cc1	10.1021/acs.jmedchem.6b00981
		10686633	56532	0	None	-1621	2	Guinea pig	4.4	pKi	=	4.4	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	313	5	2	3	3.6	O=C(Nc1ccccc1C(F)(F)F)OCCCc1c[nH]cn1	10.1021/jm9507688
		CHEMBL16373	56532	0	None	-1621	2	Guinea pig	4.4	pKi	=	4.4	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	313	5	2	3	3.6	O=C(Nc1ccccc1C(F)(F)F)OCCCc1c[nH]cn1	10.1021/jm9507688
		10682710	57493	1	None	-3801	2	Guinea pig	4.4	pKi	=	4.4	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	259	6	2	3	2.3	O=C(NCc1ccccc1)OCCCc1c[nH]cn1	10.1021/jm9507688
		CHEMBL16592	57493	1	None	-3801	2	Guinea pig	4.4	pKi	=	4.4	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	259	6	2	3	2.3	O=C(NCc1ccccc1)OCCCc1c[nH]cn1	10.1021/jm9507688
		10474353	58777	0	None	-4168	2	Guinea pig	4.4	pKi	=	4.4	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	371	5	2	3	3.2	O=C(Nc1ccc(I)cc1)OCCCc1c[nH]cn1	10.1021/jm9507688
		CHEMBL16874	58777	0	None	-4168	2	Guinea pig	4.4	pKi	=	4.4	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	371	5	2	3	3.2	O=C(Nc1ccc(I)cc1)OCCCc1c[nH]cn1	10.1021/jm9507688
		1204	1932	119	None	-501	24	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor S3.36C mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor S3.36C mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1038/nchembio714
		1247	1932	119	None	-501	24	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor S3.36C mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor S3.36C mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1038/nchembio714
		1375	1932	119	None	-501	24	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor S3.36C mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor S3.36C mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1038/nchembio714
		774	1932	119	None	-501	24	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor S3.36C mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor S3.36C mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1038/nchembio714
		CHEMBL90	1932	119	None	-501	24	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor S3.36C mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor S3.36C mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1038/nchembio714
		DB05381	1932	119	None	-501	24	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor S3.36C mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor S3.36C mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1038/nchembio714
		2775690	93011	53	None	-15	6	Human	6.4	pKi	=	6.4	Binding	Binding affinity to histamine H1 receptor (unknown origin)Binding affinity to histamine H1 receptor (unknown origin)	ChEMBL	295	1	1	3	3.0	Cc1ccc2nc(C(F)(F)F)cc(N3CCNCC3)c2c1	10.1021/ml400312j
		CHEMBL2441619	93011	53	None	-15	6	Human	6.4	pKi	=	6.4	Binding	Binding affinity to histamine H1 receptor (unknown origin)Binding affinity to histamine H1 receptor (unknown origin)	ChEMBL	295	1	1	3	3.0	Cc1ccc2nc(C(F)(F)F)cc(N3CCNCC3)c2c1	10.1021/ml400312j
		11265950	195913	0	None	-6	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	279	5	0	3	3.0	CN(C)CCC1=C(Cc2cnccn2)c2ccccc2C1	10.1016/j.bmcl.2010.02.055
		CHEMBL559251	195913	0	None	-6	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	279	5	0	3	3.0	CN(C)CCC1=C(Cc2cnccn2)c2ccccc2C1	10.1016/j.bmcl.2010.02.055
		11265950	195913	0	None	-6	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	279	5	0	3	3.0	CN(C)CCC1=C(Cc2cnccn2)c2ccccc2C1	10.1016/j.bmcl.2010.12.053
		CHEMBL559251	195913	0	None	-6	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	279	5	0	3	3.0	CN(C)CCC1=C(Cc2cnccn2)c2ccccc2C1	10.1016/j.bmcl.2010.12.053
		11265950	195913	0	None	-6	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation counting	ChEMBL	279	5	0	3	3.0	CN(C)CCC1=C(Cc2cnccn2)c2ccccc2C1	10.1021/jm900933k
		CHEMBL559251	195913	0	None	-6	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation counting	ChEMBL	279	5	0	3	3.0	CN(C)CCC1=C(Cc2cnccn2)c2ccccc2C1	10.1021/jm900933k
		11580427	196610	11	None	1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation counting	ChEMBL	310	5	0	3	4.6	C[C@@H](c1ccccn1)c1c(CCN(C)C)sc2ccccc12	10.1021/jm900933k
		CHEMBL564144	196610	11	None	1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation counting	ChEMBL	310	5	0	3	4.6	C[C@@H](c1ccccn1)c1c(CCN(C)C)sc2ccccc12	10.1021/jm900933k
		11465618	102398	23	None	-14	19	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]pyrilamine from recombinant human H1 receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]pyrilamine from recombinant human H1 receptor measured after 60 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
		CHEMBL3039528	102398	23	None	-14	19	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]pyrilamine from recombinant human H1 receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]pyrilamine from recombinant human H1 receptor measured after 60 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
		CHEMBL5191141	102398	23	None	-14	19	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]pyrilamine from recombinant human H1 receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]pyrilamine from recombinant human H1 receptor measured after 60 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
		44312705	103098	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cellsIn vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	454	7	2	5	4.1	NC(=O)N(O)Cc1ccc(CN2CCN([C@H](c3ccccc3)c3ccc(Cl)cc3)CC2)o1	10.1016/j.bmcl.2004.02.005
		CHEMBL307609	103098	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cellsIn vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	454	7	2	5	4.1	NC(=O)N(O)Cc1ccc(CN2CCN([C@H](c3ccccc3)c3ccc(Cl)cc3)CC2)o1	10.1016/j.bmcl.2004.02.005
		11580427	196610	11	None	1	2	Human	8.4	pKi	=	8.4	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	310	5	0	3	4.6	C[C@@H](c1ccccn1)c1c(CCN(C)C)sc2ccccc12	10.1016/j.bmcl.2010.07.117
		CHEMBL564144	196610	11	None	1	2	Human	8.4	pKi	=	8.4	Binding	Inhibition of histamine H1 receptorInhibition of histamine H1 receptor	ChEMBL	310	5	0	3	4.6	C[C@@H](c1ccccn1)c1c(CCN(C)C)sc2ccccc12	10.1016/j.bmcl.2010.07.117
		46884699	8305	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	307	5	0	3	3.9	Cc1ccc2c(c1)CC(CCN(C)C)=C2[C@@H](C)c1cnccn1	10.1016/j.bmcl.2010.02.055
		CHEMBL1092663	8305	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	307	5	0	3	3.9	Cc1ccc2c(c1)CC(CCN(C)C)=C2[C@@H](C)c1cnccn1	10.1016/j.bmcl.2010.02.055
		14127191	11297	0	None	-	1	Guinea pig	8.4	pKi	=	8.4	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	323	4	1	3	3.7	CN(C)CC/C=C1\c2ccccc2COc2ccc(C(=O)O)cc21	10.1021/jm00089a020
		CHEMBL1179239	11297	0	None	-	1	Guinea pig	8.4	pKi	=	8.4	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	323	4	1	3	3.7	CN(C)CC/C=C1\c2ccccc2COc2ccc(C(=O)O)cc21	10.1021/jm00089a020
		CHEMBL65822	11297	0	None	-	1	Guinea pig	8.4	pKi	=	8.4	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	323	4	1	3	3.7	CN(C)CC/C=C1\c2ccccc2COc2ccc(C(=O)O)cc21	10.1021/jm00089a020
		15749428	100876	0	None	-	1	Guinea pig	8.4	pKi	=	8.4	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	351	6	1	3	4.0	CN(C)CC/C=C1\c2ccccc2COc2ccc(CCC(=O)O)cc21	10.1021/jm00089a020
		CHEMBL293652	100876	0	None	-	1	Guinea pig	8.4	pKi	=	8.4	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	351	6	1	3	4.0	CN(C)CC/C=C1\c2ccccc2COc2ccc(CCC(=O)O)cc21	10.1021/jm00089a020
		9805944	56227	37	None	-6	9	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptorDisplacement of [3H]pyrilamine from human histamine H1 receptor	ChEMBL	462	7	2	3	4.7	CNC(=O)C(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1	10.1021/jm800510m
		CHEMBL1627	56227	37	None	-6	9	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptorDisplacement of [3H]pyrilamine from human histamine H1 receptor	ChEMBL	462	7	2	3	4.7	CNC(=O)C(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1	10.1021/jm800510m
		2726	919	68	None	-2	72	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2008.09.012
		621	919	68	None	-2	72	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2008.09.012
		83	919	68	None	-2	72	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2008.09.012
		CHEMBL71	919	68	None	-2	72	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2008.09.012
		DB00477	919	68	None	-2	72	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2008.09.012
		44326336	111413	0	None	5	3	Human	8.4	pKi	=	8.4	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	311	2	0	3	4.3	CN(C)CC1C[C@@H]2c3ccccc3Sc3ccccc3[C@H]2O1	10.1016/j.bmcl.2004.03.069
		CHEMBL327306	111413	0	None	5	3	Human	8.4	pKi	=	8.4	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	311	2	0	3	4.3	CN(C)CC1C[C@@H]2c3ccccc3Sc3ccccc3[C@H]2O1	10.1016/j.bmcl.2004.03.069
		53320189	57755	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	291	5	0	3	3.1	c1ccc2c(c1)CC(CCN1CCC1)=C2Cc1cnccn1	10.1016/j.bmcl.2010.12.053
		CHEMBL1669412	57755	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	291	5	0	3	3.1	c1ccc2c(c1)CC(CCN1CCC1)=C2Cc1cnccn1	10.1016/j.bmcl.2010.12.053
		9949441	114461	0	None	2	5	Rat	8.4	pKi	=	8.4	Binding	Half-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenateHalf-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenate	ChEMBL	331	2	0	4	3.5	CCN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		CHEMBL333455	114461	0	None	2	5	Rat	8.4	pKi	=	8.4	Binding	Half-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenateHalf-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenate	ChEMBL	331	2	0	4	3.5	CCN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		135398745	2914	112	None	-1	65	Rat	8.4	pKi	=	8.4	Binding	In vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamineIn vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamine	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm0309811
		47	2914	112	None	-1	65	Rat	8.4	pKi	=	8.4	Binding	In vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamineIn vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamine	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm0309811
		CHEMBL715	2914	112	None	-1	65	Rat	8.4	pKi	=	8.4	Binding	In vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamineIn vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamine	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm0309811
		DB00334	2914	112	None	-1	65	Rat	8.4	pKi	=	8.4	Binding	In vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamineIn vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamine	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm0309811
		44401243	168494	0	None	-1	9	Human	8.4	pKi	=	8.4	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	329	2	0	3	4.6	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL435301	168494	0	None	-1	9	Human	8.4	pKi	=	8.4	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	329	2	0	3	4.6	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1	10.1021/jm049632c
		46830289	8360	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	299	5	0	4	3.8	C[C@H](c1c(CCN(C)C)sc2ccccc12)n1cccn1	10.1016/j.bmcl.2010.01.134
		CHEMBL1093058	8360	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	299	5	0	4	3.8	C[C@H](c1c(CCN(C)C)sc2ccccc12)n1cccn1	10.1016/j.bmcl.2010.01.134
		6726	1280	51	None	3	13	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		7151	1280	51	None	3	13	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		749	1280	51	None	3	13	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		CHEMBL648	1280	51	None	3	13	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		DB01176	1280	51	None	3	13	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		1210	918	51	None	-20	21	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/j.bmcl.2013.12.024
		1213	918	51	None	-20	21	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/j.bmcl.2013.12.024
		2725	918	51	None	-20	21	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/j.bmcl.2013.12.024
		33036	918	51	None	-20	21	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/j.bmcl.2013.12.024
		4411	918	51	None	-20	21	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/j.bmcl.2013.12.024
		616	918	51	None	-20	21	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/j.bmcl.2013.12.024
		6976	918	51	None	-20	21	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/j.bmcl.2013.12.024
		716121	918	51	None	-20	21	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/j.bmcl.2013.12.024
		CHEMBL1201353	918	51	None	-20	21	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/j.bmcl.2013.12.024
		CHEMBL1554789	918	51	None	-20	21	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/j.bmcl.2013.12.024
		CHEMBL505	918	51	None	-20	21	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/j.bmcl.2013.12.024
		DB01114	918	51	None	-20	21	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/j.bmcl.2013.12.024
		DB13679	918	51	None	-20	21	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/j.bmcl.2013.12.024
		1227	2489	43	None	-2	12	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmcl.2011.09.001
		2331	2489	43	None	-2	12	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmcl.2011.09.001
		3957	2489	43	None	-2	12	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmcl.2011.09.001
		4992	2489	43	None	-2	12	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmcl.2011.09.001
		CHEMBL511	2489	43	None	-2	12	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmcl.2011.09.001
		DB06691	2489	43	None	-2	12	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1016/j.bmcl.2011.09.001
		49782794	17916	0	None	-16	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsDisplacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	409	4	1	4	4.0	CC(C)C(=O)NCc1ccc2c(c1)[C@H](N1CCN(C)CC1)Cc1ccccc1S2	10.1021/jm100652h
		CHEMBL1259189	17916	0	None	-16	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsDisplacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	409	4	1	4	4.0	CC(C)C(=O)NCc1ccc2c(c1)[C@H](N1CCN(C)CC1)Cc1ccccc1S2	10.1021/jm100652h
		45272889	195900	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	422	6	1	5	4.2	Fc1ccc(Cn2c(N3CCC(NCC4CCOCC4)CC3)nc3ccccc32)cc1	10.1016/j.bmcl.2009.05.086
		CHEMBL559060	195900	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	422	6	1	5	4.2	Fc1ccc(Cn2c(N3CCC(NCC4CCOCC4)CC3)nc3ccccc32)cc1	10.1016/j.bmcl.2009.05.086
		2337	3256	77	None	1	62	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		50	3256	77	None	1	62	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		5002	3256	77	None	1	62	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		CHEMBL716	3256	77	None	1	62	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		DB01224	3256	77	None	1	62	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		25056048	102613	0	None	-	1	Guinea pig	8.3	pKi	=	8.3	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	351	6	1	3	4.0	CN(C)CCC/C=C1/c2ccccc2COc2ccc(CC(=O)O)cc21	10.1021/jm00089a020
		CHEMBL304185	102613	0	None	-	1	Guinea pig	8.3	pKi	=	8.3	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	351	6	1	3	4.0	CN(C)CCC/C=C1/c2ccccc2COc2ccc(CC(=O)O)cc21	10.1021/jm00089a020
		46884201	8145	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	316	5	0	4	4.6	C[C@@H](c1cscn1)c1c(CCN(C)C)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		CHEMBL1091782	8145	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	316	5	0	4	4.6	C[C@@H](c1cscn1)c1c(CCN(C)C)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		11023546	78478	0	None	2	4	Rat	8.3	pKi	=	8.3	Binding	Half-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenateHalf-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN([C@H]2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		CHEMBL2111783	78478	0	None	2	4	Rat	8.3	pKi	=	8.3	Binding	Half-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenateHalf-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN([C@H]2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		1212	1662	50	None	-41	65	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		204	1662	50	None	-41	65	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		3372	1662	50	None	-41	65	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		CHEMBL726	1662	50	None	-41	65	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		DB00623	1662	50	None	-41	65	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		49836299	18744	0	None	10	5	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation countingDisplacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation counting	ChEMBL	375	2	1	2	4.4	O=C(O)C1CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
		CHEMBL1277770	18744	0	None	10	5	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation countingDisplacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation counting	ChEMBL	375	2	1	2	4.4	O=C(O)C1CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
		46889258	7541	0	None	316	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation counting	ChEMBL	302	6	0	5	2.2	CCOCCn1c(N2CC[C@H](N(C)C)C2)nc2ccccc21	10.1016/j.bmcl.2010.03.027
		CHEMBL1087493	7541	0	None	316	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation counting	ChEMBL	302	6	0	5	2.2	CCOCCn1c(N2CC[C@H](N(C)C)C2)nc2ccccc21	10.1016/j.bmcl.2010.03.027
		51039226	57768	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	370	7	0	4	4.5	C[C@H](C1=C(CCN(C)Cc2ccncc2)Cc2ccccc21)c1cnccn1	10.1016/j.bmcl.2010.12.053
		CHEMBL1669425	57768	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	370	7	0	4	4.5	C[C@H](C1=C(CCN(C)Cc2ccncc2)Cc2ccccc21)c1cnccn1	10.1016/j.bmcl.2010.12.053
		44267118	9698	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.	ChEMBL	396	1	1	3	4.3	CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cc(C(C)O)cnc32)CC1	10.1016/S0960-894X(00)80290-5
		CHEMBL11313	9698	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.	ChEMBL	396	1	1	3	4.3	CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cc(C(C)O)cnc32)CC1	10.1016/S0960-894X(00)80290-5
		17867054	48941	0	None	-1	4	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptorDisplacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptor	ChEMBL	435	5	0	5	4.3	Cn1c(=O)sc2cc(CCN3CCN(Cc4ccc(Cl)c(Cl)c4)CC3)ccc21	10.1016/s0960-894x(02)00123-3
		CHEMBL15601	48941	0	None	-1	4	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptorDisplacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptor	ChEMBL	435	5	0	5	4.3	Cn1c(=O)sc2cc(CCN3CCN(Cc4ccc(Cl)c(Cl)c4)CC3)ccc21	10.1016/s0960-894x(02)00123-3
		137646281	157806	0	None	-91	17	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-pyrilamine from recombinant human H1 receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-pyrilamine from recombinant human H1 receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	423	8	0	7	3.8	COc1ccccc1N1CCN(CCCSc2nnc(-c3ccccc3)n2C)CC1	10.1021/acs.jmedchem.9b00412
		CHEMBL4083252	157806	0	None	-91	17	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-pyrilamine from recombinant human H1 receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-pyrilamine from recombinant human H1 receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	423	8	0	7	3.8	COc1ccccc1N1CCN(CCCSc2nnc(-c3ccccc3)n2C)CC1	10.1021/acs.jmedchem.9b00412
		72152557	163072	5	None	-1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	331	6	1	5	2.8	Clc1cncc(NCCCN2CCN(c3ccccc3)CC2)n1	10.1021/acs.jmedchem.8b00718
		CHEMBL4176490	163072	5	None	-1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	331	6	1	5	2.8	Clc1cncc(NCCCN2CCN(c3ccccc3)CC2)n1	10.1021/acs.jmedchem.8b00718
		1212	1662	50	None	-41	65	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2008.09.012
		204	1662	50	None	-41	65	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2008.09.012
		3372	1662	50	None	-41	65	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2008.09.012
		CHEMBL726	1662	50	None	-41	65	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2008.09.012
		DB00623	1662	50	None	-41	65	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2008.09.012
		25212276	190066	0	None	-112	6	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	508	11	0	3	7.4	CN(CCCC12CCC(c3ccccc31)c1ccccc12)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
		CHEMBL517244	190066	0	None	-112	6	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	508	11	0	3	7.4	CN(CCCC12CCC(c3ccccc31)c1ccccc12)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
		2600	3779	74	None	1	13	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1016/j.bmcl.2009.07.047
		2608	3779	74	None	1	13	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1016/j.bmcl.2009.07.047
		5405	3779	74	None	1	13	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1016/j.bmcl.2009.07.047
		CHEMBL17157	3779	74	None	1	13	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1016/j.bmcl.2009.07.047
		DB00342	3779	74	None	1	13	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1016/j.bmcl.2009.07.047
		44308991	163497	0	None	-8	2	Guinea pig	7.4	pKi	=	7.4	Binding	Evaluated for the percent binding affinity against H1 receptor by an H1 histamine-mediated bronchospasmEvaluated for the percent binding affinity against H1 receptor by an H1 histamine-mediated bronchospasm	ChEMBL	435	12	1	5	3.8	O=S(=O)(c1ccc(Cl)cc1)N(CCCCc1c[nH]cn1)CCCCn1ccnc1	10.1016/s0960-894x(98)00379-5
		CHEMBL420181	163497	0	None	-8	2	Guinea pig	7.4	pKi	=	7.4	Binding	Evaluated for the percent binding affinity against H1 receptor by an H1 histamine-mediated bronchospasmEvaluated for the percent binding affinity against H1 receptor by an H1 histamine-mediated bronchospasm	ChEMBL	435	12	1	5	3.8	O=S(=O)(c1ccc(Cl)cc1)N(CCCCc1c[nH]cn1)CCCCn1ccnc1	10.1016/s0960-894x(98)00379-5
		168296738	192269	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	714	18	6	8	1.2	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5205682	192269	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	714	18	6	8	1.2	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168296738	192269	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	714	18	6	8	1.2	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5205682	192269	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	714	18	6	8	1.2	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		9818650	203525	0	None	-1621	4	Human	5.4	pKi	=	5.4	Binding	Compound was tested for its binding affinity towards human H1 receptorCompound was tested for its binding affinity towards human H1 receptor	ChEMBL	323	5	1	3	4.4	c1ccc2c(NCCCN3CCCC3)c3c(nc2c1)CCCCC3	10.1016/s0960-894x(03)00356-1
		CHEMBL66388	203525	0	None	-1621	4	Human	5.4	pKi	=	5.4	Binding	Compound was tested for its binding affinity towards human H1 receptorCompound was tested for its binding affinity towards human H1 receptor	ChEMBL	323	5	1	3	4.4	c1ccc2c(NCCCN3CCCC3)c3c(nc2c1)CCCCC3	10.1016/s0960-894x(03)00356-1
		162664702	182210	0	None	-29	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cell membranes co-expressing RGS4 measured after 60 mins by scintillation counting analysisDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cell membranes co-expressing RGS4 measured after 60 mins by scintillation counting analysis	ChEMBL	407	7	0	4	5.0	Clc1ccc(-c2ccc(OCCCN3CCN(c4ccncc4)CC3)cc2)cc1	10.1016/j.ejmech.2020.113041
		CHEMBL4783066	182210	0	None	-29	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cell membranes co-expressing RGS4 measured after 60 mins by scintillation counting analysisDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cell membranes co-expressing RGS4 measured after 60 mins by scintillation counting analysis	ChEMBL	407	7	0	4	5.0	Clc1ccc(-c2ccc(OCCCN3CCN(c4ccncc4)CC3)cc2)cc1	10.1016/j.ejmech.2020.113041
		53326712	57748	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	307	7	0	3	3.8	CCCN(C)CCC1=C(Cc2cnccn2)c2ccccc2C1	10.1016/j.bmcl.2010.12.053
		CHEMBL1669406	57748	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	307	7	0	3	3.8	CCCN(C)CCC1=C(Cc2cnccn2)c2ccccc2C1	10.1016/j.bmcl.2010.12.053
		10480204	116527	0	None	-	1	Guinea pig	7.4	pKi	=	7.4	Binding	Inhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptorInhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptor	ChEMBL	478	6	1	5	5.1	O=C(O)c1ccc2c(c1)C(SCCN1CCN(c3ccc(F)cc3)CC1)c1ccccc1CO2	10.1021/jm00055a013
		CHEMBL336204	116527	0	None	-	1	Guinea pig	7.4	pKi	=	7.4	Binding	Inhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptorInhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptor	ChEMBL	478	6	1	5	5.1	O=C(O)c1ccc2c(c1)C(SCCN1CCN(c3ccc(F)cc3)CC1)c1ccccc1CO2	10.1021/jm00055a013
		2389	3331	118	None	-52	67	Guinea pig	7.4	pKi	=	7.4	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellumDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C4MD00578C
		5073	3331	118	None	-52	67	Guinea pig	7.4	pKi	=	7.4	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellumDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C4MD00578C
		96	3331	118	None	-52	67	Guinea pig	7.4	pKi	=	7.4	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellumDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C4MD00578C
		CHEMBL85	3331	118	None	-52	67	Guinea pig	7.4	pKi	=	7.4	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellumDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C4MD00578C
		DB00734	3331	118	None	-52	67	Guinea pig	7.4	pKi	=	7.4	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellumDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C4MD00578C
		1605	2342	117	None	-2	4	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsBinding affinity towards human histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1016/j.bmcl.2004.08.060
		3957	2342	117	None	-2	4	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsBinding affinity towards human histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1016/j.bmcl.2004.08.060
		7216	2342	117	None	-2	4	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsBinding affinity towards human histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1016/j.bmcl.2004.08.060
		CHEMBL998	2342	117	None	-2	4	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsBinding affinity towards human histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1016/j.bmcl.2004.08.060
		DB00455	2342	117	None	-2	4	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsBinding affinity towards human histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1016/j.bmcl.2004.08.060
		13091358	70455	0	None	-1023	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-Pyrilamine from human histamine H1 receptor by liquid scintillation counterDisplacement of [3H]-Pyrilamine from human histamine H1 receptor by liquid scintillation counter	ChEMBL	389	6	1	3	4.8	OC1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2CCCOc1ccc(F)cc1	10.1016/j.bmc.2012.01.022
		CHEMBL1946122	70455	0	None	-1023	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-Pyrilamine from human histamine H1 receptor by liquid scintillation counterDisplacement of [3H]-Pyrilamine from human histamine H1 receptor by liquid scintillation counter	ChEMBL	389	6	1	3	4.8	OC1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2CCCOc1ccc(F)cc1	10.1016/j.bmc.2012.01.022
		13091356	113538	0	None	-1023	8	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation countingDisplacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation counting	ChEMBL	389	6	1	3	4.8	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCOc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
		CHEMBL3321789	113538	0	None	-1023	8	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation countingDisplacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation counting	ChEMBL	389	6	1	3	4.8	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCOc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
		44304376	202970	0	None	-7	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	423	11	0	5	4.1	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3ccccn3)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL63036	202970	0	None	-7	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	423	11	0	5	4.1	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3ccccn3)CC2)cc1	10.1016/s0960-894x(02)00309-8
		10455457	203403	0	None	-707	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	431	10	0	5	3.3	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)N3CCOCC3)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL65518	203403	0	None	-707	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	431	10	0	5	3.3	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)N3CCOCC3)CC2)cc1	10.1016/s0960-894x(02)00309-8
		112936352	137494	1	None	17	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	389	6	1	6	3.5	COc1ccc(CNc2cc(-c3ccccc3)nc(N3CCN(C)CC3)n2)cc1	10.1016/j.bmcl.2015.12.035
		CHEMBL3754008	137494	1	None	17	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	389	6	1	6	3.5	COc1ccc(CNc2cc(-c3ccccc3)nc(N3CCN(C)CC3)n2)cc1	10.1016/j.bmcl.2015.12.035
		873049	69029	8	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	269	3	0	5	2.2	c1ccc2c(c1)n(CCN1CCCCC1)c1ncnn21	10.1021/jm2011589
		CHEMBL1923531	69029	8	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	269	3	0	5	2.2	c1ccc2c(c1)n(CCN1CCCCC1)c1ncnn21	10.1021/jm2011589
		73353884	92322	0	None	-3	8	Human	5.4	pKi	=	5.4	Binding	Inhibition of histamine H1 receptor (unknown origin) by PDSP assayInhibition of histamine H1 receptor (unknown origin) by PDSP assay	ChEMBL	295	3	1	3	2.7	c1cc2c(cc1CN[C@H]1C3C4CC5C6C4CC3C6C51)OCO2	10.1016/j.bmc.2013.07.045
		CHEMBL2429890	92322	0	None	-3	8	Human	5.4	pKi	=	5.4	Binding	Inhibition of histamine H1 receptor (unknown origin) by PDSP assayInhibition of histamine H1 receptor (unknown origin) by PDSP assay	ChEMBL	295	3	1	3	2.7	c1cc2c(cc1CN[C@H]1C3C4CC5C6C4CC3C6C51)OCO2	10.1016/j.bmc.2013.07.045
		213	3853	55	None	-8	44	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		2717	3853	55	None	-8	44	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		5533	3853	55	None	-8	44	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		CHEMBL621	3853	55	None	-8	44	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		DB00656	3853	55	None	-8	44	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		9864676	127808	0	None	-2	5	Rat	7.4	pKi	=	7.4	Binding	Inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat cortexInhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat cortex	ChEMBL	380	6	0	3	4.5	O=C(CCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
		CHEMBL366388	127808	0	None	-2	5	Rat	7.4	pKi	=	7.4	Binding	Inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat cortexInhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat cortex	ChEMBL	380	6	0	3	4.5	O=C(CCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
		44401105	69576	0	None	-4	9	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	373	2	0	3	4.7	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Br)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL193435	69576	0	None	-4	9	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	373	2	0	3	4.7	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Br)cc3[C@H]2O1	10.1021/jm049632c
		10000169	22222	0	None	-	1	Guinea pig	7.4	pKi	=	7.4	Binding	Inhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptorInhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptor	ChEMBL	385	5	1	5	3.4	O=C(O)c1ccc2c(c1)C(SCCN1CCOCC1)c1ccccc1CO2	10.1021/jm00055a013
		CHEMBL132306	22222	0	None	-	1	Guinea pig	7.4	pKi	=	7.4	Binding	Inhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptorInhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptor	ChEMBL	385	5	1	5	3.4	O=C(O)c1ccc2c(c1)C(SCCN1CCOCC1)c1ccccc1CO2	10.1021/jm00055a013
		129103161	167070	0	None	-588	13	Guinea pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by liquid scintillation countingDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by liquid scintillation counting	ChEMBL	461	6	0	5	4.6	O=C(CCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2	10.1021/acs.jmedchem.8b01096
		CHEMBL4289498	167070	0	None	-588	13	Guinea pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by liquid scintillation countingDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by liquid scintillation counting	ChEMBL	461	6	0	5	4.6	O=C(CCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2	10.1021/acs.jmedchem.8b01096
		162657344	180932	0	None	-489	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cell membranes co-expressing RGS4 measured after 60 mins by scintillation counting analysisDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cell membranes co-expressing RGS4 measured after 60 mins by scintillation counting analysis	ChEMBL	388	8	1	5	4.4	c1ccc(Nc2ccc(OCCCN3CCN(c4ccncc4)CC3)cc2)cc1	10.1016/j.ejmech.2020.113041
		CHEMBL4758080	180932	0	None	-489	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cell membranes co-expressing RGS4 measured after 60 mins by scintillation counting analysisDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cell membranes co-expressing RGS4 measured after 60 mins by scintillation counting analysis	ChEMBL	388	8	1	5	4.4	c1ccc(Nc2ccc(OCCCN3CCN(c4ccncc4)CC3)cc2)cc1	10.1016/j.ejmech.2020.113041
		162666847	182457	0	None	-239	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cell membranes co-expressing RGS4 measured after 60 mins by scintillation counting analysisDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cell membranes co-expressing RGS4 measured after 60 mins by scintillation counting analysis	ChEMBL	387	8	0	4	4.3	c1ccc(Cc2ccc(OCCCN3CCN(c4ccncc4)CC3)cc2)cc1	10.1016/j.ejmech.2020.113041
		CHEMBL4786308	182457	0	None	-239	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cell membranes co-expressing RGS4 measured after 60 mins by scintillation counting analysisDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cell membranes co-expressing RGS4 measured after 60 mins by scintillation counting analysis	ChEMBL	387	8	0	4	4.3	c1ccc(Cc2ccc(OCCCN3CCN(c4ccncc4)CC3)cc2)cc1	10.1016/j.ejmech.2020.113041
		95232163	163089	1	None	-2	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	338	7	1	5	1.5	O[C@@H](COC[C@@H]1CCCO1)CN1CCN(c2ccccc2F)CC1	10.1021/acs.jmedchem.8b00718
		CHEMBL4176800	163089	1	None	-2	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	338	7	1	5	1.5	O[C@@H](COC[C@@H]1CCCO1)CN1CCN(c2ccccc2F)CC1	10.1021/acs.jmedchem.8b00718
		44304304	170063	0	None	-67	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	423	9	0	6	3.5	CCOC(=O)N1CCN(CCCOc2ccc(C(=O)/C=C/c3cccnc3)cc2)CC1	10.1016/s0960-894x(02)00309-8
		CHEMBL444307	170063	0	None	-67	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	423	9	0	6	3.5	CCOC(=O)N1CCN(CCCOc2ccc(C(=O)/C=C/c3cccnc3)cc2)CC1	10.1016/s0960-894x(02)00309-8
		44335558	110070	0	None	-43	4	Human	6.4	pKi	=	6.4	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	334	6	0	3	4.7	CC1CCN(CCCOc2ccc(-c3ccc(C#N)cc3)cc2)CC1	10.1016/s0960-894x(02)00648-0
		CHEMBL323562	110070	0	None	-43	4	Human	6.4	pKi	=	6.4	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	334	6	0	3	4.7	CC1CCN(CCCOc2ccc(-c3ccc(C#N)cc3)cc2)CC1	10.1016/s0960-894x(02)00648-0
		3300652	69022	35	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	263	1	2	5	2.3	NC1=NC(c2ccccc2)n2c(nc3ccccc32)N1	10.1021/jm2011589
		CHEMBL1923523	69022	35	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	263	1	2	5	2.3	NC1=NC(c2ccccc2)n2c(nc3ccccc32)N1	10.1021/jm2011589
		44304032	201487	0	None	-95	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	413	11	0	6	3.7	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3cnco3)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL60509	201487	0	None	-95	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	413	11	0	6	3.7	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3cnco3)CC2)cc1	10.1016/s0960-894x(02)00309-8
		129103315	167122	0	None	-5	6	Guinea pig	7.4	pKi	=	7.4	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by liquid scintillation countingDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by liquid scintillation counting	ChEMBL	477	7	1	5	4.9	O=C1CCc2cc(C(O)CCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc3c2N1CC3	10.1021/acs.jmedchem.8b01096
		CHEMBL4290311	167122	0	None	-5	6	Guinea pig	7.4	pKi	=	7.4	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by liquid scintillation countingDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by liquid scintillation counting	ChEMBL	477	7	1	5	4.9	O=C1CCc2cc(C(O)CCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc3c2N1CC3	10.1021/acs.jmedchem.8b01096
		127041705	136676	0	None	-1	5	Guinea pig	7.4	pKi	=	7.4	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellumDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum	ChEMBL	525	5	0	5	5.3	O=S(=O)(c1ccc(C(F)(F)F)cc1)N1CCC(CN2CCC(c3noc4cc(F)ccc34)CC2)CC1	10.1039/C4MD00578C
		CHEMBL3740256	136676	0	None	-1	5	Guinea pig	7.4	pKi	=	7.4	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellumDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum	ChEMBL	525	5	0	5	5.3	O=S(=O)(c1ccc(C(F)(F)F)cc1)N1CCC(CN2CCC(c3noc4cc(F)ccc34)CC2)CC1	10.1039/C4MD00578C
		44267139	9371	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.	ChEMBL	382	1	0	3	4.3	COc1cnc2c(c1)CCc1cc(Cl)ccc1C2=C1CCN(C(C)=O)CC1	10.1016/S0960-894X(00)80290-5
		CHEMBL11136	9371	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.	ChEMBL	382	1	0	3	4.3	COc1cnc2c(c1)CCc1cc(Cl)ccc1C2=C1CCN(C(C)=O)CC1	10.1016/S0960-894X(00)80290-5
		44568347	191651	0	None	-20	15	Human	6.4	pKi	=	6.4	Binding	Antagonist activity at histamine H1 receptor (unknown origin) by PDSP assayAntagonist activity at histamine H1 receptor (unknown origin) by PDSP assay	ChEMBL	356	6	0	4	5.2	CCN(CC)CCCOC(=O)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
		CHEMBL519609	191651	0	None	-20	15	Human	6.4	pKi	=	6.4	Binding	Antagonist activity at histamine H1 receptor (unknown origin) by PDSP assayAntagonist activity at histamine H1 receptor (unknown origin) by PDSP assay	ChEMBL	356	6	0	4	5.2	CCN(CC)CCCOC(=O)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
		162655547	180796	0	None	20	5	Human	6.4	pKi	=	6.4	Binding	Binding affinity to H1 receptor (unknown origin)Binding affinity to H1 receptor (unknown origin)	ChEMBL	306	4	0	2	3.8	CN(C)CCCN1C(=O)c2ccccc2/C=C\c2ccccc21	10.1016/j.bmcl.2020.127493
		CHEMBL4756446	180796	0	None	20	5	Human	6.4	pKi	=	6.4	Binding	Binding affinity to H1 receptor (unknown origin)Binding affinity to H1 receptor (unknown origin)	ChEMBL	306	4	0	2	3.8	CN(C)CCCN1C(=O)c2ccccc2/C=C\c2ccccc21	10.1016/j.bmcl.2020.127493
		44334503	4995	0	None	-281	3	Human	4.4	pKi	=	4.4	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	349	9	3	6	0.2	CC(=O)c1ccc(OCCCN2CC[C@H](NC(=O)[C@@H](N)CO)C2)cc1	10.1016/s0960-894x(02)00685-6
		CHEMBL104994	4995	0	None	-281	3	Human	4.4	pKi	=	4.4	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	349	9	3	6	0.2	CC(=O)c1ccc(OCCCN2CC[C@H](NC(=O)[C@@H](N)CO)C2)cc1	10.1016/s0960-894x(02)00685-6
		44335407	171844	0	None	-1	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	452	8	0	5	4.8	CCOC(=O)N1CCN(CCCOc2ccc(-c3ccc(OC(F)(F)F)cc3)cc2)CC1	10.1016/s0960-894x(02)00648-0
		CHEMBL446885	171844	0	None	-1	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	452	8	0	5	4.8	CCOC(=O)N1CCN(CCCOc2ccc(-c3ccc(OC(F)(F)F)cc3)cc2)CC1	10.1016/s0960-894x(02)00648-0
		168280835	190722	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	818	20	6	8	3.8	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5182490	190722	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	818	20	6	8	3.8	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168293792	192177	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	834	21	7	9	2.8	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5204037	192177	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	834	21	7	9	2.8	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		44304293	202962	0	None	-15	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	491	10	1	6	4.0	N[C@H](Cc1cc2ccccc2s1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		CHEMBL63002	202962	0	None	-15	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	491	10	1	6	4.0	N[C@H](Cc1cc2ccccc2s1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		168280835	190722	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	818	20	6	8	3.8	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5182490	190722	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	818	20	6	8	3.8	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168293792	192177	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	834	21	7	9	2.8	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5204037	192177	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	834	21	7	9	2.8	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		44582678	181574	0	None	-3	10	Human	6.4	pKi	=	6.4	Binding	Inhibition of human cloned histamine H1 receptor by competitive binding experimentInhibition of human cloned histamine H1 receptor by competitive binding experiment	ChEMBL	401	9	1	4	4.3	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
		CHEMBL476839	181574	0	None	-3	10	Human	6.4	pKi	=	6.4	Binding	Inhibition of human cloned histamine H1 receptor by competitive binding experimentInhibition of human cloned histamine H1 receptor by competitive binding experiment	ChEMBL	401	9	1	4	4.3	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
		71937057	119575	3	None	-1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	341	6	2	4	2.0	Cc1cccc(N2CCN(CCCNC(=O)c3cn[nH]c3C)CC2)c1	10.1021/acs.jmedchem.8b00718
		CHEMBL3461530	119575	3	None	-1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	341	6	2	4	2.0	Cc1cccc(N2CCN(CCCNC(=O)c3cn[nH]c3C)CC2)c1	10.1021/acs.jmedchem.8b00718
		1353	1911	93	None	-489	83	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2008.06.030
		3559	1911	93	None	-489	83	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2008.06.030
		86	1911	93	None	-489	83	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2008.06.030
		CHEMBL54	1911	93	None	-489	83	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2008.06.030
		DB00502	1911	93	None	-489	83	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2008.06.030
		1353	1911	93	None	-489	83	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation countingDisplacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2014.07.018
		3559	1911	93	None	-489	83	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation countingDisplacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2014.07.018
		86	1911	93	None	-489	83	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation countingDisplacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2014.07.018
		CHEMBL54	1911	93	None	-489	83	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation countingDisplacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2014.07.018
		DB00502	1911	93	None	-489	83	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation countingDisplacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2014.07.018
		1353	1911	93	None	-489	83	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]pyrilamine from human H1 receptor by liquid scintillation countingDisplacement of [3H]pyrilamine from human H1 receptor by liquid scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2011.12.019
		3559	1911	93	None	-489	83	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]pyrilamine from human H1 receptor by liquid scintillation countingDisplacement of [3H]pyrilamine from human H1 receptor by liquid scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2011.12.019
		86	1911	93	None	-489	83	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]pyrilamine from human H1 receptor by liquid scintillation countingDisplacement of [3H]pyrilamine from human H1 receptor by liquid scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2011.12.019
		CHEMBL54	1911	93	None	-489	83	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]pyrilamine from human H1 receptor by liquid scintillation countingDisplacement of [3H]pyrilamine from human H1 receptor by liquid scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2011.12.019
		DB00502	1911	93	None	-489	83	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]pyrilamine from human H1 receptor by liquid scintillation countingDisplacement of [3H]pyrilamine from human H1 receptor by liquid scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2011.12.019
		44334781	5406	0	None	-1513	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	458	11	1	6	3.1	COc1ccc(S(=O)(=O)N[C@H]2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)C2)cc1	10.1016/s0960-894x(02)00685-6
		CHEMBL107162	5406	0	None	-1513	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	458	11	1	6	3.1	COc1ccc(S(=O)(=O)N[C@H]2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)C2)cc1	10.1016/s0960-894x(02)00685-6
		20659961	116095	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting method	ChEMBL	434	2	0	2	6.2	O=C(CC1CCCCC1)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/jm501086v
		CHEMBL3357045	116095	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting method	ChEMBL	434	2	0	2	6.2	O=C(CC1CCCCC1)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/jm501086v
		71449142	79518	0	None	-7	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	442	9	0	6	4.2	CCOC(=O)N1CCN(CCCOc2ccc(C(=O)c3ccc(SC)cc3)cc2)CC1	10.1016/s0960-894x(02)00309-8
		CHEMBL2113738	79518	0	None	-7	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	442	9	0	6	4.2	CCOC(=O)N1CCN(CCCOc2ccc(C(=O)c3ccc(SC)cc3)cc2)CC1	10.1016/s0960-894x(02)00309-8
		44335430	5297	0	None	-1	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	374	7	0	5	4.0	CCOC(=O)N1CCN(CCCOc2ccc(-c3cccs3)cc2)CC1	10.1016/s0960-894x(02)00648-0
		CHEMBL106602	5297	0	None	-1	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	374	7	0	5	4.0	CCOC(=O)N1CCN(CCCOc2ccc(-c3cccs3)cc2)CC1	10.1016/s0960-894x(02)00648-0
		9880208	4924	0	None	-537	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity at human cortical Histamine 1 receptorBinding affinity at human cortical Histamine 1 receptor	ChEMBL	322	6	1	4	3.1	N#Cc1ccc(-c2ccc(OCCCN3CC[C@@H](O)C3)cc2)cc1	10.1016/s0960-894x(02)00648-0
		CHEMBL104669	4924	0	None	-537	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity at human cortical Histamine 1 receptorBinding affinity at human cortical Histamine 1 receptor	ChEMBL	322	6	1	4	3.1	N#Cc1ccc(-c2ccc(OCCCN3CC[C@@H](O)C3)cc2)cc1	10.1016/s0960-894x(02)00648-0
		164622153	185568	0	None	-95	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	394	6	4	4	3.0	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccc(Cl)cc1	10.1016/j.ejmech.2021.113190
		CHEMBL4863347	185568	0	None	-95	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	394	6	4	4	3.0	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccc(Cl)cc1	10.1016/j.ejmech.2021.113190
		164610824	185110	0	None	-30	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	452	8	4	4	3.6	Cc1nc(N)sc1CCCN/C(N)=N/C(=S)NCC(c1ccccc1)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4856200	185110	0	None	-30	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	452	8	4	4	3.6	Cc1nc(N)sc1CCCN/C(N)=N/C(=S)NCC(c1ccccc1)c1ccccc1	10.1016/j.ejmech.2021.113190
		44334025	4547	0	None	-1202	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	462	10	1	5	3.8	O=C(c1ccc(OCCCN2CC[C@H](NS(=O)(=O)c3ccccc3Cl)C2)cc1)C1CC1	10.1016/s0960-894x(02)00685-6
		CHEMBL102384	4547	0	None	-1202	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	462	10	1	5	3.8	O=C(c1ccc(OCCCN2CC[C@H](NS(=O)(=O)c3ccccc3Cl)C2)cc1)C1CC1	10.1016/s0960-894x(02)00685-6
		44304223	200389	0	None	-48	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	374	12	0	4	4.5	CCCCCC(=O)c1ccc(OCCCN2CCN(CC(C)C)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL59798	200389	0	None	-48	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	374	12	0	4	4.5	CCCCCC(=O)c1ccc(OCCCN2CCN(CC(C)C)CC2)cc1	10.1016/s0960-894x(02)00309-8
		57390225	67882	0	None	-53	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	469	9	2	5	4.1	COc1ccc(CN(CCN[C@H]2CCN(C(=O)c3cc4ccccc4[nH]3)C2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		CHEMBL1910384	67882	0	None	-53	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	469	9	2	5	4.1	COc1ccc(CN(CCN[C@H]2CCN(C(=O)c3cc4ccccc4[nH]3)C2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		44304049	102138	0	None	-165	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	421	9	1	5	2.9	N[C@@H](C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1)c1ccccc1	10.1016/s0960-894x(02)00310-4
		CHEMBL302468	102138	0	None	-165	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	421	9	1	5	2.9	N[C@@H](C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1)c1ccccc1	10.1016/s0960-894x(02)00310-4
		17156312	69030	14	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	215	4	1	2	3.4	CC(C)NCc1ccc(-c2ccccc2)o1	10.1021/jm2011589
		CHEMBL1923532	69030	14	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	215	4	1	2	3.4	CC(C)NCc1ccc(-c2ccccc2)o1	10.1021/jm2011589
		44304003	203134	0	None	-1584	3	Human	4.3	pKi	=	4.3	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	384	9	1	6	1.4	N#CC[C@@H](N)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		CHEMBL64124	203134	0	None	-1584	3	Human	4.3	pKi	=	4.3	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	384	9	1	6	1.4	N#CC[C@@H](N)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		164609493	184436	0	None	-2630	6	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	350	6	4	5	1.9	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccco1	10.1016/j.ejmech.2021.113190
		CHEMBL4846380	184436	0	None	-2630	6	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	350	6	4	5	1.9	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccco1	10.1016/j.ejmech.2021.113190
		162676676	183589	0	None	-223	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cell membranes co-expressing RGS4 measured after 60 mins by scintillation counting analysisDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cell membranes co-expressing RGS4 measured after 60 mins by scintillation counting analysis	ChEMBL	389	8	0	5	4.5	c1ccc(Oc2ccc(OCCCN3CCN(c4ccncc4)CC3)cc2)cc1	10.1016/j.ejmech.2020.113041
		CHEMBL4800672	183589	0	None	-223	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cell membranes co-expressing RGS4 measured after 60 mins by scintillation counting analysisDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cell membranes co-expressing RGS4 measured after 60 mins by scintillation counting analysis	ChEMBL	389	8	0	5	4.5	c1ccc(Oc2ccc(OCCCN3CCN(c4ccncc4)CC3)cc2)cc1	10.1016/j.ejmech.2020.113041
		60165681	75356	0	None	-1	6	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]Pyrilamine from human H1 histamine receptor by liquid scintillation assayDisplacement of [3H]Pyrilamine from human H1 histamine receptor by liquid scintillation assay	ChEMBL	413	7	0	5	5.1	O=C(CCCCN1CCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
		CHEMBL2037528	75356	0	None	-1	6	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]Pyrilamine from human H1 histamine receptor by liquid scintillation assayDisplacement of [3H]Pyrilamine from human H1 histamine receptor by liquid scintillation assay	ChEMBL	413	7	0	5	5.1	O=C(CCCCN1CCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
		2389	3331	118	None	-52	67	Guinea pig	7.3	pKi	=	7.3	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by liquid scintillation countingDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by liquid scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/acs.jmedchem.8b01096
		5073	3331	118	None	-52	67	Guinea pig	7.3	pKi	=	7.3	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by liquid scintillation countingDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by liquid scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/acs.jmedchem.8b01096
		96	3331	118	None	-52	67	Guinea pig	7.3	pKi	=	7.3	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by liquid scintillation countingDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by liquid scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/acs.jmedchem.8b01096
		CHEMBL85	3331	118	None	-52	67	Guinea pig	7.3	pKi	=	7.3	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by liquid scintillation countingDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by liquid scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/acs.jmedchem.8b01096
		DB00734	3331	118	None	-52	67	Guinea pig	7.3	pKi	=	7.3	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by liquid scintillation countingDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by liquid scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/acs.jmedchem.8b01096
		44324737	207238	0	None	-158	5	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]pyrilamine binding to Histamine H1 receptorInhibition of [3H]pyrilamine binding to Histamine H1 receptor	ChEMBL	473	6	0	7	3.8	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(Cc4ccc5ccccc5c4)CC3)[C@@H]1CO2	10.1021/jm049619s
		CHEMBL92860	207238	0	None	-158	5	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]pyrilamine binding to Histamine H1 receptorInhibition of [3H]pyrilamine binding to Histamine H1 receptor	ChEMBL	473	6	0	7	3.8	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(Cc4ccc5ccccc5c4)CC3)[C@@H]1CO2	10.1021/jm049619s
		53326725	57758	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	327	5	0	3	3.4	FC1(F)CN(CCC2=C(Cc3cnccn3)c3ccccc3C2)C1	10.1016/j.bmcl.2010.12.053
		CHEMBL1669415	57758	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	327	5	0	3	3.4	FC1(F)CN(CCC2=C(Cc3cnccn3)c3ccccc3C2)C1	10.1016/j.bmcl.2010.12.053
		118721934	116096	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting method	ChEMBL	423	3	1	3	4.6	CC(C)C[C@@H](N)C(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/jm501086v
		CHEMBL3357049	116096	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in Sf9 cells by scintillation counting method	ChEMBL	423	3	1	3	4.6	CC(C)C[C@@H](N)C(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/jm501086v
		44304320	163274	0	None	-1862	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	373	9	1	5	1.9	CC[C@H](N)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		CHEMBL418666	163274	0	None	-1862	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	373	9	1	5	1.9	CC[C@H](N)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		44304449	200499	0	None	-323	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	531	14	1	6	5.3	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@@H](CC(C)C)NC(=O)OC(C)(C)C)CC2)cc1	10.1016/s0960-894x(02)00310-4
		CHEMBL59870	200499	0	None	-323	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	531	14	1	6	5.3	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@@H](CC(C)C)NC(=O)OC(C)(C)C)CC2)cc1	10.1016/s0960-894x(02)00310-4
		44304348	100602	0	None	-11748	3	Human	4.3	pKi	=	4.3	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	387	10	1	5	2.3	CCC[C@@H](N)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		CHEMBL291821	100602	0	None	-11748	3	Human	4.3	pKi	=	4.3	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	387	10	1	5	2.3	CCC[C@@H](N)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		44304056	102724	1	None	-5370	3	Human	4.3	pKi	=	4.3	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	401	10	1	5	2.6	CC(C)N[C@H](C)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		CHEMBL304888	102724	1	None	-5370	3	Human	4.3	pKi	=	4.3	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	401	10	1	5	2.6	CC(C)N[C@H](C)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		44304462	202882	0	None	-6606	3	Human	4.3	pKi	=	4.3	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	405	12	2	6	1.7	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@H](N)CO)CC2)cc1	10.1016/s0960-894x(02)00310-4
		CHEMBL62660	202882	0	None	-6606	3	Human	4.3	pKi	=	4.3	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	405	12	2	6	1.7	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@H](N)CO)CC2)cc1	10.1016/s0960-894x(02)00310-4
		44304316	203133	0	None	-389	3	Human	4.3	pKi	=	4.3	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	485	8	0	6	3.6	CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		CHEMBL64120	203133	0	None	-389	3	Human	4.3	pKi	=	4.3	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	485	8	0	6	3.6	CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		1278	2150	84	None	-1778	8	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.09.001
		1279	2150	84	None	-1778	8	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.09.001
		4908365	2150	84	None	-1778	8	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.09.001
		CHEMBL129198	2150	84	None	-1778	8	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1016/j.bmcl.2011.09.001
		164610289	185133	0	None	-77	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	438	7	4	4	3.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=S)NC(c1ccccc1)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4856602	185133	0	None	-77	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	438	7	4	4	3.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=S)NC(c1ccccc1)c1ccccc1	10.1016/j.ejmech.2021.113190
		2865	4143	73	None	-58	53	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.bmc.2008.06.030
		59	4143	73	None	-58	53	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.bmc.2008.06.030
		60854	4143	73	None	-58	53	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.bmc.2008.06.030
		CHEMBL708	4143	73	None	-58	53	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.bmc.2008.06.030
		DB00246	4143	73	None	-58	53	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.bmc.2008.06.030
		10411944	22228	0	None	-	1	Guinea pig	7.3	pKi	=	7.3	Binding	Inhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptorInhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptor	ChEMBL	460	6	1	5	4.9	O=C(O)c1ccc2c(c1)C(SCCN1CCN(c3ccccc3)CC1)c1ccccc1CO2	10.1021/jm00055a013
		CHEMBL132311	22228	0	None	-	1	Guinea pig	7.3	pKi	=	7.3	Binding	Inhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptorInhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptor	ChEMBL	460	6	1	5	4.9	O=C(O)c1ccc2c(c1)C(SCCN1CCN(c3ccccc3)CC1)c1ccccc1CO2	10.1021/jm00055a013
		44326124	106955	0	None	1	3	Human	7.3	pKi	=	7.3	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	427	3	0	3	6.6	c1ccc(C2CCN(CC3C[C@@H]4c5ccccc5Sc5ccccc5[C@H]4O3)CC2)cc1	10.1016/j.bmcl.2004.03.069
		CHEMBL314968	106955	0	None	1	3	Human	7.3	pKi	=	7.3	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	427	3	0	3	6.6	c1ccc(C2CCN(CC3C[C@@H]4c5ccccc5Sc5ccccc5[C@H]4O3)CC2)cc1	10.1016/j.bmcl.2004.03.069
		73213195	104459	0	None	-1	12	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
		CHEMBL3104092	104459	0	None	-1	12	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
		44326219	207158	0	None	-8	3	Human	6.3	pKi	=	6.3	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	444	3	0	3	5.7	Clc1cccc(N2CCN(CC3C[C@@H]4c5ccccc5Cc5ccccc5[C@H]4O3)CC2)c1	10.1016/j.bmcl.2004.03.069
		CHEMBL92333	207158	0	None	-8	3	Human	6.3	pKi	=	6.3	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	444	3	0	3	5.7	Clc1cccc(N2CCN(CC3C[C@@H]4c5ccccc5Cc5ccccc5[C@H]4O3)CC2)c1	10.1016/j.bmcl.2004.03.069
		73355415	92533	0	None	-23	13	Human	5.3	pKi	=	5.3	Binding	Inhibition of histamine H1 receptor (unknown origin) by PDSP assayInhibition of histamine H1 receptor (unknown origin) by PDSP assay	ChEMBL	277	3	1	1	2.1	C1C2C3CC4C2C2C1C3[C@H](NCC13C5C6C7C5C1C7C63)C42	10.1016/j.bmc.2013.07.045
		CHEMBL2432039	92533	0	None	-23	13	Human	5.3	pKi	=	5.3	Binding	Inhibition of histamine H1 receptor (unknown origin) by PDSP assayInhibition of histamine H1 receptor (unknown origin) by PDSP assay	ChEMBL	277	3	1	1	2.1	C1C2C3CC4C2C2C1C3[C@H](NCC13C5C6C7C5C1C7C63)C42	10.1016/j.bmc.2013.07.045
		44304269	100544	0	None	-75	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	423	11	0	5	4.1	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3ccncc3)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL291394	100544	0	None	-75	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	423	11	0	5	4.1	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3ccncc3)CC2)cc1	10.1016/s0960-894x(02)00309-8
		53325600	57763	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	376	7	0	5	4.6	C[C@H](C1=C(CCN(C)Cc2nccs2)Cc2ccccc21)c1cnccn1	10.1016/j.bmcl.2010.12.053
		CHEMBL1669420	57763	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	376	7	0	5	4.6	C[C@H](C1=C(CCN(C)Cc2nccs2)Cc2ccccc21)c1cnccn1	10.1016/j.bmcl.2010.12.053
		14554129	10535	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	366	1	0	2	4.7	CCC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/jm00105a069
		CHEMBL116935	10535	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	366	1	0	2	4.7	CCC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/jm00105a069
		46929648	16759	0	None	3	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	355	5	2	3	4.3	FC(F)(F)c1ccc(SC[C@@H](c2c[nH]cn2)C2CCNCC2)cc1	10.1021/jm100643t
		CHEMBL1243395	16759	0	None	3	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	355	5	2	3	4.3	FC(F)(F)c1ccc(SC[C@@H](c2c[nH]cn2)C2CCNCC2)cc1	10.1021/jm100643t
		73213195	104459	0	None	-1	12	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
		CHEMBL3104092	104459	0	None	-1	12	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
		44521012	199979	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cellsDisplacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cells	ChEMBL	237	3	1	1	3.3	CNCCC1c2ccccc2Cc2ccccc21	10.1016/j.bmc.2009.08.016
		CHEMBL595158	199979	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cellsDisplacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cells	ChEMBL	237	3	1	1	3.3	CNCCC1c2ccccc2Cc2ccccc21	10.1016/j.bmc.2009.08.016
		133	2496	52	None	-102	42	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		1723	2496	52	None	-102	42	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		28693	2496	52	None	-102	42	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		CHEMBL19215	2496	52	None	-102	42	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		DB13520	2496	52	None	-102	42	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		132060743	162236	0	None	-1	13	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-Pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	351	3	0	4	3.1	CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1	10.1016/j.ejmech.2018.02.024
		CHEMBL4163428	162236	0	None	-1	13	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-Pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	351	3	0	4	3.1	CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1	10.1016/j.ejmech.2018.02.024
		164620704	186083	0	None	-33	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	416	8	4	4	3.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)c1ccc(C(C)C)cc1	10.1016/j.ejmech.2021.113190
		CHEMBL4871482	186083	0	None	-33	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	416	8	4	4	3.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)c1ccc(C(C)C)cc1	10.1016/j.ejmech.2021.113190
		44343626	114149	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	341	1	0	3	2.7	CN1CCN(C2c3ccc(Cl)cc3CCc3cccnc32)CC1=O	10.1016/s0960-894x(98)00626-x
		CHEMBL332936	114149	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	341	1	0	3	2.7	CN1CCN(C2c3ccc(Cl)cc3CCc3cccnc32)CC1=O	10.1016/s0960-894x(98)00626-x
		53321512	57757	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	309	5	0	3	3.1	FC1CN(CCC2=C(Cc3cnccn3)c3ccccc3C2)C1	10.1016/j.bmcl.2010.12.053
		CHEMBL1669414	57757	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	309	5	0	3	3.1	FC1CN(CCC2=C(Cc3cnccn3)c3ccccc3C2)C1	10.1016/j.bmcl.2010.12.053
		71459761	84080	0	None	-81	7	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation counting analysisDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation counting analysis	ChEMBL	540	7	0	5	6.1	COc1ccccc1N1CCN(Cc2cc(CN3CCN(c4ccc(Cl)cc4)CC3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		CHEMBL2207642	84080	0	None	-81	7	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation counting analysisDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation counting analysis	ChEMBL	540	7	0	5	6.1	COc1ccccc1N1CCN(Cc2cc(CN3CCN(c4ccc(Cl)cc4)CC3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		10326069	39296	1	None	-27	9	Human	6.3	pKi	=	6.3	Binding	Binding affinity for recombinant human Histamine H1 receptor using [3H]pyrilamine as radioligand.Binding affinity for recombinant human Histamine H1 receptor using [3H]pyrilamine as radioligand.	ChEMBL	589	10	3	8	3.3	CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980506g
		CHEMBL147077	39296	1	None	-27	9	Human	6.3	pKi	=	6.3	Binding	Binding affinity for recombinant human Histamine H1 receptor using [3H]pyrilamine as radioligand.Binding affinity for recombinant human Histamine H1 receptor using [3H]pyrilamine as radioligand.	ChEMBL	589	10	3	8	3.3	CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980506g
		25055258	12056	0	None	-	1	Guinea pig	8.3	pKi	=	8.3	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	349	4	1	3	4.2	O=C(O)c1ccc2c(c1)/C(=C\CCN1CCCC1)c1ccccc1CO2	10.1021/jm00089a020
		CHEMBL1183550	12056	0	None	-	1	Guinea pig	8.3	pKi	=	8.3	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	349	4	1	3	4.2	O=C(O)c1ccc2c(c1)/C(=C\CCN1CCCC1)c1ccccc1CO2	10.1021/jm00089a020
		CHEMBL304223	12056	0	None	-	1	Guinea pig	8.3	pKi	=	8.3	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	349	4	1	3	4.2	O=C(O)c1ccc2c(c1)/C(=C\CCN1CCCC1)c1ccccc1CO2	10.1021/jm00089a020
		135398737	958	93	None	-4	89	Rat	8.3	pKi	=	8.3	Binding	Compound was tested for the binding affinity against rat cortical H1 receptor by radioligand [3H]-pyrilamine binding assay.Compound was tested for the binding affinity against rat cortical H1 receptor by radioligand [3H]-pyrilamine binding assay.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
		38	958	93	None	-4	89	Rat	8.3	pKi	=	8.3	Binding	Compound was tested for the binding affinity against rat cortical H1 receptor by radioligand [3H]-pyrilamine binding assay.Compound was tested for the binding affinity against rat cortical H1 receptor by radioligand [3H]-pyrilamine binding assay.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
		722	958	93	None	-4	89	Rat	8.3	pKi	=	8.3	Binding	Compound was tested for the binding affinity against rat cortical H1 receptor by radioligand [3H]-pyrilamine binding assay.Compound was tested for the binding affinity against rat cortical H1 receptor by radioligand [3H]-pyrilamine binding assay.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
		CHEMBL42	958	93	None	-4	89	Rat	8.3	pKi	=	8.3	Binding	Compound was tested for the binding affinity against rat cortical H1 receptor by radioligand [3H]-pyrilamine binding assay.Compound was tested for the binding affinity against rat cortical H1 receptor by radioligand [3H]-pyrilamine binding assay.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
		DB00363	958	93	None	-4	89	Rat	8.3	pKi	=	8.3	Binding	Compound was tested for the binding affinity against rat cortical H1 receptor by radioligand [3H]-pyrilamine binding assay.Compound was tested for the binding affinity against rat cortical H1 receptor by radioligand [3H]-pyrilamine binding assay.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
		49782998	17917	0	None	-31	5	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsDisplacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	409	4	1	4	4.0	CC(C)C(=O)NCc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2	10.1021/jm100652h
		CHEMBL1259190	17917	0	None	-31	5	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsDisplacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	409	4	1	4	4.0	CC(C)C(=O)NCc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2	10.1021/jm100652h
		46884120	8056	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	340	6	0	4	4.6	COc1cccnc1[C@H](C)c1c(CCN(C)C)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		CHEMBL1091069	8056	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	340	6	0	4	4.6	COc1cccnc1[C@H](C)c1c(CCN(C)C)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		44389293	128805	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity for human Histamine H1 receptor in CHO K1 cellsBinding affinity for human Histamine H1 receptor in CHO K1 cells	ChEMBL	577	11	1	6	5.7	COC(=O)N(O)CCC#Cc1ccc(OCCCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1016/j.bmcl.2004.12.023
		CHEMBL366925	128805	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity for human Histamine H1 receptor in CHO K1 cellsBinding affinity for human Histamine H1 receptor in CHO K1 cells	ChEMBL	577	11	1	6	5.7	COC(=O)N(O)CCC#Cc1ccc(OCCCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1016/j.bmcl.2004.12.023
		CHEMBL5272464	194625	0	None	11	3	Human	8.3	pKi	=	8.3	Binding	Antagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysisAntagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysis	ChEMBL	480	10	1	5	4.4	CCCNC(=O)CCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		CHEMBL5315453	194625	0	None	11	3	Human	8.3	pKi	=	8.3	Binding	Antagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysisAntagonist activity against recombinant human H1 receptor expressed in CHO cells incubated for 30 mins by FLIPR analysis	ChEMBL	480	10	1	5	4.4	CCCNC(=O)CCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
		69260946	81294	1	None	19	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	462	6	1	4	5.5	O=C(O)c1cccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158823	81294	1	None	19	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	462	6	1	4	5.5	O=C(O)c1cccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1	10.1016/j.bmcl.2012.08.103
		69274365	81297	1	None	7	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	476	7	1	4	5.4	O=C(O)Cc1cccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158826	81297	1	None	7	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	476	7	1	4	5.4	O=C(O)Cc1cccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1	10.1016/j.bmcl.2012.08.103
		71449585	81300	0	None	7	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	492	8	1	5	5.2	O=C(O)COc1cccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158829	81300	0	None	7	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	492	8	1	5	5.2	O=C(O)COc1cccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1	10.1016/j.bmcl.2012.08.103
		59295969	84017	0	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	608	10	4	7	2.9	O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(S(=O)(=O)NC3CC3)ccc12	10.1016/j.bmcl.2012.09.112
		CHEMBL2207285	84017	0	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	608	10	4	7	2.9	O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(S(=O)(=O)NC3CC3)ccc12	10.1016/j.bmcl.2012.09.112
		71454296	84095	0	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	521	7	2	6	3.3	Cn1cc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c(C(F)(F)F)cc1=O	10.1016/j.bmcl.2012.09.112
		CHEMBL2207665	84095	0	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	521	7	2	6	3.3	Cn1cc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c(C(F)(F)F)cc1=O	10.1016/j.bmcl.2012.09.112
		155521446	170583	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	402	2	0	4	4.7	Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(Cc2ccncn2)CC1	10.1021/acs.jmedchem.9b00447
		CHEMBL4450560	170583	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	402	2	0	4	4.7	Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(Cc2ccncn2)CC1	10.1021/acs.jmedchem.9b00447
		10069660	206908	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	401	2	0	3	5.3	Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(Cc2cccnc2)CC1	10.1021/acs.jmedchem.9b00447
		CHEMBL90893	206908	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	401	2	0	3	5.3	Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(Cc2cccnc2)CC1	10.1021/acs.jmedchem.9b00447
		28125512	203423	25	None	-	1	Guinea pig	8.3	pKi	=	8.3	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	337	5	1	3	3.6	CN(C)CC/C=C1\c2ccccc2COc2ccc(CC(=O)O)cc21	10.1021/jm00089a020
		5284599	203423	25	None	-	1	Guinea pig	8.3	pKi	=	8.3	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	337	5	1	3	3.6	CN(C)CC/C=C1\c2ccccc2COc2ccc(CC(=O)O)cc21	10.1021/jm00089a020
		CHEMBL65699	203423	25	None	-	1	Guinea pig	8.3	pKi	=	8.3	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	337	5	1	3	3.6	CN(C)CC/C=C1\c2ccccc2COc2ccc(CC(=O)O)cc21	10.1021/jm00089a020
		46884202	8202	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	316	5	0	4	4.6	C[C@@H](c1cncs1)c1c(CCN(C)C)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		CHEMBL1092118	8202	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	316	5	0	4	4.6	C[C@@H](c1cncs1)c1c(CCN(C)C)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		2865	4143	73	None	-58	53	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm030480f
		59	4143	73	None	-58	53	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm030480f
		60854	4143	73	None	-58	53	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm030480f
		CHEMBL708	4143	73	None	-58	53	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm030480f
		DB00246	4143	73	None	-58	53	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm030480f
		49836528	18658	0	None	5	5	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation countingDisplacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation counting	ChEMBL	373	2	1	2	4.0	O=C(O)[C@]12C[C@H]1CN(C1CC[C@]3(Cc4ccccc4Cc4ccccc43)C1)C2	10.1021/jm100856p
		CHEMBL1276947	18658	0	None	5	5	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation countingDisplacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation counting	ChEMBL	373	2	1	2	4.0	O=C(O)[C@]12C[C@H]1CN(C1CC[C@]3(Cc4ccccc4Cc4ccccc43)C1)C2	10.1021/jm100856p
		57393730	67884	0	None	-1	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	579	8	2	6	5.0	O=C(c1cc2ccccc2[nH]1)N1CCN(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)CC1	10.1016/j.bmcl.2011.09.001
		CHEMBL1910386	67884	0	None	-1	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	579	8	2	6	5.0	O=C(c1cc2ccccc2[nH]1)N1CCN(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)CC1	10.1016/j.bmcl.2011.09.001
		1210	918	51	None	-9	21	Rat	8.3	pKi	=	8.3	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/s0960-894x(98)00626-x
		1213	918	51	None	-9	21	Rat	8.3	pKi	=	8.3	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/s0960-894x(98)00626-x
		2725	918	51	None	-9	21	Rat	8.3	pKi	=	8.3	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/s0960-894x(98)00626-x
		33036	918	51	None	-9	21	Rat	8.3	pKi	=	8.3	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/s0960-894x(98)00626-x
		4411	918	51	None	-9	21	Rat	8.3	pKi	=	8.3	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/s0960-894x(98)00626-x
		616	918	51	None	-9	21	Rat	8.3	pKi	=	8.3	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/s0960-894x(98)00626-x
		6976	918	51	None	-9	21	Rat	8.3	pKi	=	8.3	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/s0960-894x(98)00626-x
		716121	918	51	None	-9	21	Rat	8.3	pKi	=	8.3	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/s0960-894x(98)00626-x
		CHEMBL1201353	918	51	None	-9	21	Rat	8.3	pKi	=	8.3	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/s0960-894x(98)00626-x
		CHEMBL1554789	918	51	None	-9	21	Rat	8.3	pKi	=	8.3	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/s0960-894x(98)00626-x
		CHEMBL505	918	51	None	-9	21	Rat	8.3	pKi	=	8.3	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/s0960-894x(98)00626-x
		DB01114	918	51	None	-9	21	Rat	8.3	pKi	=	8.3	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/s0960-894x(98)00626-x
		DB13679	918	51	None	-9	21	Rat	8.3	pKi	=	8.3	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1016/s0960-894x(98)00626-x
		1210	918	51	None	-9	21	Rat	8.3	pKi	=	8.3	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00105a069
		1213	918	51	None	-9	21	Rat	8.3	pKi	=	8.3	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00105a069
		2725	918	51	None	-9	21	Rat	8.3	pKi	=	8.3	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00105a069
		33036	918	51	None	-9	21	Rat	8.3	pKi	=	8.3	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00105a069
		4411	918	51	None	-9	21	Rat	8.3	pKi	=	8.3	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00105a069
		616	918	51	None	-9	21	Rat	8.3	pKi	=	8.3	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00105a069
		6976	918	51	None	-9	21	Rat	8.3	pKi	=	8.3	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00105a069
		716121	918	51	None	-9	21	Rat	8.3	pKi	=	8.3	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00105a069
		CHEMBL1201353	918	51	None	-9	21	Rat	8.3	pKi	=	8.3	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00105a069
		CHEMBL1554789	918	51	None	-9	21	Rat	8.3	pKi	=	8.3	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00105a069
		CHEMBL505	918	51	None	-9	21	Rat	8.3	pKi	=	8.3	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00105a069
		DB01114	918	51	None	-9	21	Rat	8.3	pKi	=	8.3	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00105a069
		DB13679	918	51	None	-9	21	Rat	8.3	pKi	=	8.3	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm00105a069
		135398745	2914	112	None	1	65	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human H1 receptorBinding affinity towards human H1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm0002432
		47	2914	112	None	1	65	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human H1 receptorBinding affinity towards human H1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm0002432
		CHEMBL715	2914	112	None	1	65	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human H1 receptorBinding affinity towards human H1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm0002432
		DB00334	2914	112	None	1	65	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human H1 receptorBinding affinity towards human H1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm0002432
		49836633	18659	0	None	1	5	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation countingDisplacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation counting	ChEMBL	347	2	1	2	3.6	O=C(O)C1CN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
		CHEMBL1276948	18659	0	None	1	5	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation countingDisplacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation counting	ChEMBL	347	2	1	2	3.6	O=C(O)C1CN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
		15749431	100995	0	None	-	1	Guinea pig	8.2	pKi	=	8.2	Binding	The compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMThe compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	337	5	1	3	4.1	CN(C)CCC/C=C1/c2ccccc2COc2ccc(C(=O)O)cc21	10.1021/jm00089a020
		CHEMBL294345	100995	0	None	-	1	Guinea pig	8.2	pKi	=	8.2	Binding	The compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMThe compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	337	5	1	3	4.1	CN(C)CCC/C=C1/c2ccccc2COc2ccc(C(=O)O)cc21	10.1021/jm00089a020
		1971	2866	38	None	-1	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		2404	2866	38	None	-1	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		4543	2866	38	None	-1	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		CHEMBL445	2866	38	None	-1	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		DB00540	2866	38	None	-1	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		1222	881	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Histamine H1 receptor in CHO K1 cellsBinding affinity for human Histamine H1 receptor in CHO K1 cells	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1016/j.bmcl.2004.12.023
		2678	881	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Histamine H1 receptor in CHO K1 cellsBinding affinity for human Histamine H1 receptor in CHO K1 cells	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1016/j.bmcl.2004.12.023
		581	881	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Histamine H1 receptor in CHO K1 cellsBinding affinity for human Histamine H1 receptor in CHO K1 cells	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1016/j.bmcl.2004.12.023
		CHEMBL1000	881	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Histamine H1 receptor in CHO K1 cellsBinding affinity for human Histamine H1 receptor in CHO K1 cells	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1016/j.bmcl.2004.12.023
		DB00341	881	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Histamine H1 receptor in CHO K1 cellsBinding affinity for human Histamine H1 receptor in CHO K1 cells	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1016/j.bmcl.2004.12.023
		11376787	63380	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Histamine H1 receptor in CHO K1 cellsBinding affinity for human Histamine H1 receptor in CHO K1 cells	ChEMBL	591	12	1	6	6.1	CCOC(=O)N(O)CCC#Cc1ccc(OCCCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1016/j.bmcl.2004.12.023
		CHEMBL179590	63380	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Histamine H1 receptor in CHO K1 cellsBinding affinity for human Histamine H1 receptor in CHO K1 cells	ChEMBL	591	12	1	6	6.1	CCOC(=O)N(O)CCC#Cc1ccc(OCCCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1016/j.bmcl.2004.12.023
		1214	2068	54	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity for H1 histamine receptor expressed in CHO cellsBinding affinity for H1 histamine receptor expressed in CHO cells	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1	10.1021/jm049495j
		1549000	2068	54	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity for H1 histamine receptor expressed in CHO cellsBinding affinity for H1 histamine receptor expressed in CHO cells	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1	10.1021/jm049495j
		1566	2068	54	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity for H1 histamine receptor expressed in CHO cellsBinding affinity for H1 histamine receptor expressed in CHO cells	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1	10.1021/jm049495j
		28145931	2068	54	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity for H1 histamine receptor expressed in CHO cellsBinding affinity for H1 histamine receptor expressed in CHO cells	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1	10.1021/jm049495j
		CHEMBL1201191	2068	54	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity for H1 histamine receptor expressed in CHO cellsBinding affinity for H1 histamine receptor expressed in CHO cells	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1	10.1021/jm049495j
		DB06282	2068	54	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity for H1 histamine receptor expressed in CHO cellsBinding affinity for H1 histamine receptor expressed in CHO cells	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1	10.1021/jm049495j
		2865	4143	73	None	-58	53	Human	7.3	pKi	=	7.3	Binding	Binding affinity to H1 histamine receptor (unknown origin)Binding affinity to H1 histamine receptor (unknown origin)	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.bmcl.2020.127681
		59	4143	73	None	-58	53	Human	7.3	pKi	=	7.3	Binding	Binding affinity to H1 histamine receptor (unknown origin)Binding affinity to H1 histamine receptor (unknown origin)	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.bmcl.2020.127681
		60854	4143	73	None	-58	53	Human	7.3	pKi	=	7.3	Binding	Binding affinity to H1 histamine receptor (unknown origin)Binding affinity to H1 histamine receptor (unknown origin)	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.bmcl.2020.127681
		CHEMBL708	4143	73	None	-58	53	Human	7.3	pKi	=	7.3	Binding	Binding affinity to H1 histamine receptor (unknown origin)Binding affinity to H1 histamine receptor (unknown origin)	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.bmcl.2020.127681
		DB00246	4143	73	None	-58	53	Human	7.3	pKi	=	7.3	Binding	Binding affinity to H1 histamine receptor (unknown origin)Binding affinity to H1 histamine receptor (unknown origin)	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.bmcl.2020.127681
		12992629	122599	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsBinding affinity towards human histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	584	8	2	5	6.1	NC(=O)N(O)CCC#Cc1ccc(OCCCCN2CCC(=C3c4ccc(Cl)cc4CCc4cccnc43)CC2)cc1	10.1016/j.bmcl.2004.08.060
		CHEMBL360202	122599	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsBinding affinity towards human histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	584	8	2	5	6.1	NC(=O)N(O)CCC#Cc1ccc(OCCCCN2CCC(=C3c4ccc(Cl)cc4CCc4cccnc43)CC2)cc1	10.1016/j.bmcl.2004.08.060
		21509921	104458	0	None	-4	24	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)	ChEMBL	288	0	0	2	3.7	CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1	10.1016/j.bmcl.2013.12.024
		CHEMBL3104091	104458	0	None	-4	24	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)	ChEMBL	288	0	0	2	3.7	CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1	10.1016/j.bmcl.2013.12.024
		9870460	102859	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cellsIn vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	496	7	2	5	3.8	NC(=O)N(O)CCC#C[C@@H]1CC[C@@H](CN2CCN([C@H](c3ccccc3)c3ccc(Cl)cc3)CC2)O1	10.1016/j.bmcl.2004.02.005
		CHEMBL305662	102859	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cellsIn vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	496	7	2	5	3.8	NC(=O)N(O)CCC#C[C@@H]1CC[C@@H](CN2CCN([C@H](c3ccccc3)c3ccc(Cl)cc3)CC2)O1	10.1016/j.bmcl.2004.02.005
		71462100	81280	0	None	-39	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	502	8	1	4	5.4	Cc1cc(OC2CCN(CC3CCN([C@@](C)(Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc1Cl	10.1016/j.bmcl.2012.08.103
		CHEMBL2158792	81280	0	None	-39	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	502	8	1	4	5.4	Cc1cc(OC2CCN(CC3CCN([C@@](C)(Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc1Cl	10.1016/j.bmcl.2012.08.103
		10005242	81290	0	None	-3	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	476	7	1	4	5.4	O=C(O)C(c1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158819	81290	0	None	-3	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	476	7	1	4	5.4	O=C(O)C(c1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		69347980	81304	1	None	5	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	476	7	1	4	5.4	O=C(O)c1cccc(CN2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158832	81304	1	None	5	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	476	7	1	4	5.4	O=C(O)c1cccc(CN2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1	10.1016/j.bmcl.2012.08.103
		71072040	81307	0	None	-5	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	490	8	1	4	5.2	O=C(O)[C@H](Cc1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158835	81307	0	None	-5	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	490	8	1	4	5.2	O=C(O)[C@H](Cc1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		71072044	81309	0	None	-5	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	524	8	1	4	5.9	O=C(O)[C@H](Cc1ccccc1Cl)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158837	81309	0	None	-5	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	524	8	1	4	5.9	O=C(O)[C@H](Cc1ccccc1Cl)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		71072050	81311	0	None	-5	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	508	8	1	4	5.4	O=C(O)[C@H](Cc1ccccc1F)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158839	81311	0	None	-5	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	508	8	1	4	5.4	O=C(O)[C@H](Cc1ccccc1F)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		71072118	81313	0	None	-5	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	508	8	1	4	5.4	O=C(O)[C@H](Cc1ccc(F)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158841	81313	0	None	-5	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	508	8	1	4	5.4	O=C(O)[C@H](Cc1ccc(F)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		59295946	84013	0	None	-5	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	612	11	5	8	1.7	O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(S(=O)(=O)NCCO)ccc12	10.1016/j.bmcl.2012.09.112
		CHEMBL2207281	84013	0	None	-5	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	612	11	5	8	1.7	O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(S(=O)(=O)NCCO)ccc12	10.1016/j.bmcl.2012.09.112
		59295974	84102	0	None	-19	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	581	8	3	7	3.2	Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4cc(S(C)(=O)=O)ccc34)CC2)c1Cl	10.1016/j.bmcl.2012.09.112
		CHEMBL2207672	84102	0	None	-19	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	581	8	3	7	3.2	Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4cc(S(C)(=O)=O)ccc34)CC2)c1Cl	10.1016/j.bmcl.2012.09.112
		21509921	104458	0	None	-4	24	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)	ChEMBL	288	0	0	2	3.7	CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1	10.1016/j.bmcl.2013.12.024
		CHEMBL3104091	104458	0	None	-4	24	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)Displacement of [3H]Pyrilamine from histamine H1 receptor (unknown origin)	ChEMBL	288	0	0	2	3.7	CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1	10.1016/j.bmcl.2013.12.024
		1222	881	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor S3.36A mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor S3.36A mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/nchembio714
		2678	881	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor S3.36A mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor S3.36A mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/nchembio714
		581	881	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor S3.36A mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor S3.36A mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/nchembio714
		CHEMBL1000	881	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor S3.36A mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor S3.36A mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/nchembio714
		DB00341	881	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor S3.36A mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor S3.36A mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/nchembio714
		1222	881	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]mepyramine from human wild-type histamine H1 receptor expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human wild-type histamine H1 receptor expressed in COS-7 cells by liquid scintillation counting	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/nchembio714
		2678	881	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]mepyramine from human wild-type histamine H1 receptor expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human wild-type histamine H1 receptor expressed in COS-7 cells by liquid scintillation counting	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/nchembio714
		581	881	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]mepyramine from human wild-type histamine H1 receptor expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human wild-type histamine H1 receptor expressed in COS-7 cells by liquid scintillation counting	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/nchembio714
		CHEMBL1000	881	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]mepyramine from human wild-type histamine H1 receptor expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human wild-type histamine H1 receptor expressed in COS-7 cells by liquid scintillation counting	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/nchembio714
		DB00341	881	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]mepyramine from human wild-type histamine H1 receptor expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human wild-type histamine H1 receptor expressed in COS-7 cells by liquid scintillation counting	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/nchembio714
		2726	919	68	None	-6	72	Guinea pig	7.3	pKi	=	7.3	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm070516u
		621	919	68	None	-6	72	Guinea pig	7.3	pKi	=	7.3	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm070516u
		83	919	68	None	-6	72	Guinea pig	7.3	pKi	=	7.3	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm070516u
		CHEMBL71	919	68	None	-6	72	Guinea pig	7.3	pKi	=	7.3	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm070516u
		DB00477	919	68	None	-6	72	Guinea pig	7.3	pKi	=	7.3	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm070516u
		17963208	82253	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	529	5	1	5	4.5	O=C(NS(=O)(=O)c1ccc(F)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.124
		CHEMBL2171034	82253	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	529	5	1	5	4.5	O=C(NS(=O)(=O)c1ccc(F)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.124
		17963334	82257	0	None	-2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	525	5	1	5	4.7	Cc1ccccc1S(=O)(=O)NC(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.124
		CHEMBL2171038	82257	0	None	-2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	525	5	1	5	4.7	Cc1ccccc1S(=O)(=O)NC(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.124
		71457010	82258	0	None	-10	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	545	5	1	5	5.1	O=C(NS(=O)(=O)c1ccccc1Cl)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.124
		CHEMBL2171039	82258	0	None	-10	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	545	5	1	5	5.1	O=C(NS(=O)(=O)c1ccccc1Cl)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.124
		10143016	82273	0	None	3	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	525	6	1	5	4.5	O=C(NS(=O)(=O)Cc1ccccc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.124
		CHEMBL2171215	82273	0	None	3	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	525	6	1	5	4.5	O=C(NS(=O)(=O)Cc1ccccc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.124
		10947658	28702	0	None	-457	16	Human	6.3	pKi	=	6.3	Binding	Binding affinity against Histamine H1 receptorBinding affinity against Histamine H1 receptor	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
		CHEMBL137781	28702	0	None	-457	16	Human	6.3	pKi	=	6.3	Binding	Binding affinity against Histamine H1 receptorBinding affinity against Histamine H1 receptor	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
		9826801	107937	0	None	-2187	11	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsDisplacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	488	6	1	7	3.2	Cn1nnc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1	10.1021/jm100652h
		CHEMBL319352	107937	0	None	-2187	11	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsDisplacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	488	6	1	7	3.2	Cn1nnc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1	10.1021/jm100652h
		10414153	21539	0	None	-	1	Guinea pig	6.3	pKi	=	6.3	Binding	Inhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptorInhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptor	ChEMBL	515	6	2	7	5.5	O=C(O)c1ccc2c(c1)C(SCCN1CCC(n3c(O)nc4ccccc43)CC1)c1ccccc1CO2	10.1021/jm00055a013
		CHEMBL131648	21539	0	None	-	1	Guinea pig	6.3	pKi	=	6.3	Binding	Inhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptorInhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptor	ChEMBL	515	6	2	7	5.5	O=C(O)c1ccc2c(c1)C(SCCN1CCC(n3c(O)nc4ccccc43)CC1)c1ccccc1CO2	10.1021/jm00055a013
		14885641	115088	0	None	-	1	Rat	5.3	pKi	=	5.3	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	317	0	0	1	4.2	CC(=O)N1CCC(=C2c3ccccc3CCc3ccccc32)CC1	10.1021/jm00105a069
		CHEMBL334318	115088	0	None	-	1	Rat	5.3	pKi	=	5.3	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	317	0	0	1	4.2	CC(=O)N1CCC(=C2c3ccccc3CCc3ccccc32)CC1	10.1021/jm00105a069
		46882182	5921	0	None	-95	5	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	567	11	1	9	4.7	CCOc1cc(CN2CCC(Nc3nc4cc(S(=O)(=O)N(C)C)ccc4o3)CC2)cc(OCC)c1-n1cccc1	10.1016/j.bmcl.2009.09.024
		CHEMBL1079686	5921	0	None	-95	5	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	567	11	1	9	4.7	CCOc1cc(CN2CCC(Nc3nc4cc(S(=O)(=O)N(C)C)ccc4o3)CC2)cc(OCC)c1-n1cccc1	10.1016/j.bmcl.2009.09.024
		168288633	191778	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	712	18	5	7	2.5	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5198008	191778	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	712	18	5	7	2.5	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		44304091	202951	0	None	-63	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	432	14	0	5	5.2	CCCCCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)OCC)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL62949	202951	0	None	-63	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	432	14	0	5	5.2	CCCCCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)OCC)CC2)cc1	10.1016/s0960-894x(02)00309-8
		44335463	4455	0	None	-8	4	Human	6.3	pKi	=	6.3	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	357	7	1	4	3.2	CCOC(=O)N1CCN(CCCOc2ccc(-c3cc[nH]c3)cc2)CC1	10.1016/s0960-894x(02)00648-0
		CHEMBL101692	4455	0	None	-8	4	Human	6.3	pKi	=	6.3	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	357	7	1	4	3.2	CCOC(=O)N1CCN(CCCOc2ccc(-c3cc[nH]c3)cc2)CC1	10.1016/s0960-894x(02)00648-0
		66615606	81273	0	None	-398	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	513	8	1	5	4.9	Cc1c(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc(C#N)c1Cl	10.1016/j.bmcl.2012.08.103
		CHEMBL2158785	81273	0	None	-398	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	513	8	1	5	4.9	Cc1c(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc(C#N)c1Cl	10.1016/j.bmcl.2012.08.103
		50878551	90745	61	None	-21	18	Human	6.3	pKi	=	6.3	Binding	Binding affinity to histamine H1 receptor (unknown origin) by competition binding assayBinding affinity to histamine H1 receptor (unknown origin) by competition binding assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2015.12.053
		CHEMBL2391541	90745	61	None	-21	18	Human	6.3	pKi	=	6.3	Binding	Binding affinity to histamine H1 receptor (unknown origin) by competition binding assayBinding affinity to histamine H1 receptor (unknown origin) by competition binding assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2015.12.053
		71459825	84200	0	None	-3	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	433	8	2	5	3.9	N#Cc1ccc(OC[C@@H](O)CNC2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)cc1	10.1016/j.bmcl.2012.09.113
		CHEMBL2208417	84200	0	None	-3	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	433	8	2	5	3.9	N#Cc1ccc(OC[C@@H](O)CNC2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)cc1	10.1016/j.bmcl.2012.09.113
		71452602	84219	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	433	8	2	5	3.9	N#Cc1cccc(OC[C@@H](O)CNC2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)c1	10.1016/j.bmcl.2012.09.113
		CHEMBL2208436	84219	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	433	8	2	5	3.9	N#Cc1cccc(OC[C@@H](O)CNC2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)c1	10.1016/j.bmcl.2012.09.113
		59296098	84098	0	None	-15	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	446	7	3	6	2.0	N#Cc1ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccccc34)CC2)cc1	10.1016/j.bmcl.2012.09.112
		CHEMBL2207668	84098	0	None	-15	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	446	7	3	6	2.0	N#Cc1ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccccc34)CC2)cc1	10.1016/j.bmcl.2012.09.112
		168288633	191778	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	712	18	5	7	2.5	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5198008	191778	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	712	18	5	7	2.5	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		18672441	95395	0	None	-691	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human cortical Histamine 1 receptorBinding affinity at human cortical Histamine 1 receptor	ChEMBL	306	6	0	3	4.1	N#Cc1ccc(-c2ccc(OCCCN3CCCC3)cc2)cc1	10.1016/s0960-894x(02)00648-0
		CHEMBL25688	95395	0	None	-691	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human cortical Histamine 1 receptorBinding affinity at human cortical Histamine 1 receptor	ChEMBL	306	6	0	3	4.1	N#Cc1ccc(-c2ccc(OCCCN3CCCC3)cc2)cc1	10.1016/s0960-894x(02)00648-0
		168290815	192973	0	None	-10232	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	327	9	4	5	1.2	CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5200771	192973	0	None	-10232	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	327	9	4	5	1.2	CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222529	192973	0	None	-10232	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	327	9	4	5	1.2	CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		10802229	56556	0	None	-794	2	Guinea pig	4.3	pKi	=	4.3	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	273	6	2	3	2.8	C[C@@H](NC(=O)OCCCc1c[nH]cn1)c1ccccc1	10.1021/jm9507688
		CHEMBL16401	56556	0	None	-794	2	Guinea pig	4.3	pKi	=	4.3	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	273	6	2	3	2.8	C[C@@H](NC(=O)OCCCc1c[nH]cn1)c1ccccc1	10.1021/jm9507688
		10729448	56564	0	None	-1584	2	Guinea pig	4.3	pKi	=	4.3	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	251	6	2	3	2.3	O=C(NCC1CCCC1)OCCCc1c[nH]cn1	10.1021/jm9507688
		CHEMBL16407	56564	0	None	-1584	2	Guinea pig	4.3	pKi	=	4.3	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	251	6	2	3	2.3	O=C(NCC1CCCC1)OCCCc1c[nH]cn1	10.1021/jm9507688
		10588560	96574	0	None	-2089	2	Guinea pig	4.3	pKi	=	4.3	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	277	6	2	3	2.4	O=C(NCc1ccc(F)cc1)OCCCc1c[nH]cn1	10.1021/jm9507688
		CHEMBL263070	96574	0	None	-2089	2	Guinea pig	4.3	pKi	=	4.3	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	277	6	2	3	2.4	O=C(NCc1ccc(F)cc1)OCCCc1c[nH]cn1	10.1021/jm9507688
		10852027	98688	0	None	-3890	2	Guinea pig	4.3	pKi	=	4.3	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	304	7	2	5	2.2	O=C(NCc1cccc([N+](=O)[O-])c1)OCCCc1c[nH]cn1	10.1021/jm9507688
		CHEMBL277537	98688	0	None	-3890	2	Guinea pig	4.3	pKi	=	4.3	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	304	7	2	5	2.2	O=C(NCc1cccc([N+](=O)[O-])c1)OCCCc1c[nH]cn1	10.1021/jm9507688
		57345618	70459	0	None	-7	6	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-Pyrilamine from human histamine H1 receptor by liquid scintillation counterDisplacement of [3H]-Pyrilamine from human histamine H1 receptor by liquid scintillation counter	ChEMBL	362	6	0	3	4.5	Fc1ccc(OCCCN2CCCN(c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmc.2012.01.022
		CHEMBL1946126	70459	0	None	-7	6	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-Pyrilamine from human histamine H1 receptor by liquid scintillation counterDisplacement of [3H]-Pyrilamine from human histamine H1 receptor by liquid scintillation counter	ChEMBL	362	6	0	3	4.5	Fc1ccc(OCCCN2CCCN(c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmc.2012.01.022
		44582675	189701	0	None	-8	15	Human	6.3	pKi	=	6.3	Binding	Inhibition of human cloned histamine H1 receptor by competitive binding experimentInhibition of human cloned histamine H1 receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1[C@H](O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		CHEMBL515472	189701	0	None	-8	15	Human	6.3	pKi	=	6.3	Binding	Inhibition of human cloned histamine H1 receptor by competitive binding experimentInhibition of human cloned histamine H1 receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1[C@H](O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		14554127	113325	0	None	3	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	380	2	0	2	5.1	CCCC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/jm00105a069
		CHEMBL331603	113325	0	None	3	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	380	2	0	2	5.1	CCCC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/jm00105a069
		2865	4143	73	None	-58	53	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human H1 receptorBinding affinity towards human H1 receptor	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm0002432
		59	4143	73	None	-58	53	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human H1 receptorBinding affinity towards human H1 receptor	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm0002432
		60854	4143	73	None	-58	53	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human H1 receptorBinding affinity towards human H1 receptor	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm0002432
		CHEMBL708	4143	73	None	-58	53	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human H1 receptorBinding affinity towards human H1 receptor	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm0002432
		DB00246	4143	73	None	-58	53	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human H1 receptorBinding affinity towards human H1 receptor	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm0002432
		73346042	91834	5	None	-5128	17	Human	6.3	pKi	=	6.3	Binding	Binding affinity to histamine H1 receptor (unknown origin)Binding affinity to histamine H1 receptor (unknown origin)	ChEMBL	405	9	0	8	0.9	Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O	10.1016/j.bmc.2013.05.050
		CHEMBL2413153	91834	5	None	-5128	17	Human	6.3	pKi	=	6.3	Binding	Binding affinity to histamine H1 receptor (unknown origin)Binding affinity to histamine H1 receptor (unknown origin)	ChEMBL	405	9	0	8	0.9	Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O	10.1016/j.bmc.2013.05.050
		168269172	190002	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	684	17	5	7	1.8	C[C@H](NC(=O)CNC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5171289	190002	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	684	17	5	7	1.8	C[C@H](NC(=O)CNC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168286426	192926	0	None	-58	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	403	10	4	5	2.3	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5198795	192926	0	None	-58	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	403	10	4	5	2.3	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222241	192926	0	None	-58	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	403	10	4	5	2.3	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		164618508	185932	0	None	-165	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	374	6	4	4	2.7	Cc1ccc(C(C)NC(=O)/N=C(\N)NCCCc2sc(N)nc2C)cc1	10.1016/j.ejmech.2021.113190
		CHEMBL4869194	185932	0	None	-165	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	374	6	4	4	2.7	Cc1ccc(C(C)NC(=O)/N=C(\N)NCCCc2sc(N)nc2C)cc1	10.1016/j.ejmech.2021.113190
		168269172	190002	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	684	17	5	7	1.8	C[C@H](NC(=O)CNC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5171289	190002	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	684	17	5	7	1.8	C[C@H](NC(=O)CNC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		83632	5180	7	None	1	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cellsDisplacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cells	ChEMBL	225	4	0	1	3.4	CN(C)CC(c1ccccc1)c1ccccc1	10.1016/j.bmc.2009.08.016
		CHEMBL10602	5180	7	None	1	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cellsDisplacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cells	ChEMBL	225	4	0	1	3.4	CN(C)CC(c1ccccc1)c1ccccc1	10.1016/j.bmc.2009.08.016
		60165413	75360	0	None	-15	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]Pyrilamine from human H1 histamine receptor by liquid scintillation assayDisplacement of [3H]Pyrilamine from human H1 histamine receptor by liquid scintillation assay	ChEMBL	378	7	0	4	5.5	O=C(CCCCN1CCC(c2ccccc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
		CHEMBL2037531	75360	0	None	-15	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]Pyrilamine from human H1 histamine receptor by liquid scintillation assayDisplacement of [3H]Pyrilamine from human H1 histamine receptor by liquid scintillation assay	ChEMBL	378	7	0	4	5.5	O=C(CCCCN1CCC(c2ccccc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
		11848677	148352	0	None	-1	5	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	460	8	2	8	3.0	CCOc1cc(CN2CCC(Nc3nc4cc(S(N)(=O)=O)ccc4o3)CC2)ccc1OC	10.1016/j.bmcl.2009.09.024
		CHEMBL393718	148352	0	None	-1	5	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	460	8	2	8	3.0	CCOc1cc(CN2CCC(Nc3nc4cc(S(N)(=O)=O)ccc4o3)CC2)ccc1OC	10.1016/j.bmcl.2009.09.024
		10341609	200270	0	None	-117	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	412	11	1	5	3.4	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3c[nH]cn3)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL59715	200270	0	None	-117	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	412	11	1	5	3.4	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3c[nH]cn3)CC2)cc1	10.1016/s0960-894x(02)00309-8
		168274129	192809	0	None	-16	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	370	12	5	6	1.0	NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5176780	192809	0	None	-16	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	370	12	5	6	1.0	NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221468	192809	0	None	-16	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	370	12	5	6	1.0	NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		168294770	193020	0	None	-2	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	436	6	4	4	4.3	Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5208327	193020	0	None	-2	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	436	6	4	4	4.3	Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222806	193020	0	None	-2	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	436	6	4	4	4.3	Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)cc1	10.1021/acs.jmedchem.1c00692
		168295803	193045	0	None	-3	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	338	6	4	4	1.6	CCCCCNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		CHEMBL5207206	193045	0	None	-3	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	338	6	4	4	1.6	CCCCCNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222937	193045	0	None	-3	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	338	6	4	4	1.6	CCCCCNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.1c00692
		112936262	137276	1	None	-3	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	389	6	1	6	3.5	COc1ccc(CNc2nc(-c3ccccc3)cc(N3CCN(C)CC3)n2)cc1	10.1016/j.bmcl.2015.12.035
		CHEMBL3752195	137276	1	None	-3	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	389	6	1	6	3.5	COc1ccc(CNc2nc(-c3ccccc3)cc(N3CCN(C)CC3)n2)cc1	10.1016/j.bmcl.2015.12.035
		164620139	185788	0	None	-60	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	436	8	4	4	3.4	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(c1ccccc1)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4866734	185788	0	None	-60	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	436	8	4	4	3.4	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(c1ccccc1)c1ccccc1	10.1016/j.ejmech.2021.113190
		164608941	184383	0	None	-123	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	390	7	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=S)NC[C@@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4845733	184383	0	None	-123	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	390	7	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=S)NC[C@@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		3168	9262	92	None	-87	21	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	nan
		CHEMBL1108	9262	92	None	-87	21	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	nan
		17590280	69023	6	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	264	4	1	2	3.5	Cc1cccc2c(CCN)cn(Cc3ccccc3)c12	10.1021/jm2011589
		CHEMBL1923524	69023	6	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	264	4	1	2	3.5	Cc1cccc2c(CCN)cn(Cc3ccccc3)c12	10.1021/jm2011589
		168295528	193031	0	None	-2951	20	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5206565	193031	0	None	-2951	20	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222872	193031	0	None	-2951	20	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		4440801	168284	9	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	298	3	1	6	1.5	OCCN1CCN(c2ncnc3c2oc2ccccc23)CC1	10.1021/jm2011589
		CHEMBL434001	168284	9	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	298	3	1	6	1.5	OCCN1CCN(c2ncnc3c2oc2ccccc23)CC1	10.1021/jm2011589
		12016525	202915	0	None	-2630	3	Human	4.3	pKi	=	4.3	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	359	8	1	5	1.5	C[C@H](N)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		CHEMBL62804	202915	0	None	-2630	3	Human	4.3	pKi	=	4.3	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	359	8	1	5	1.5	C[C@H](N)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		164611143	184716	0	None	-234	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	414	6	4	4	2.9	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(c1ccccc1)C(F)(F)F	10.1016/j.ejmech.2021.113190
		CHEMBL4850448	184716	0	None	-234	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	414	6	4	4	2.9	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(c1ccccc1)C(F)(F)F	10.1016/j.ejmech.2021.113190
		9830741	207856	1	None	-275	6	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards Histamine H1 receptor in human brain tissue preparation, using [3H]rauwolscine as radioligand.Binding affinity towards Histamine H1 receptor in human brain tissue preparation, using [3H]rauwolscine as radioligand.	ChEMBL	475	6	1	4	5.0	C[C@@H]1OC(=O)N(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@H]1c1ccc(F)c(F)c1	10.1021/jm000085e
		CHEMBL96467	207856	1	None	-275	6	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards Histamine H1 receptor in human brain tissue preparation, using [3H]rauwolscine as radioligand.Binding affinity towards Histamine H1 receptor in human brain tissue preparation, using [3H]rauwolscine as radioligand.	ChEMBL	475	6	1	4	5.0	C[C@@H]1OC(=O)N(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@H]1c1ccc(F)c(F)c1	10.1021/jm000085e
		122196373	124287	0	None	-2	5	Guinea pig	7.3	pKi	=	7.3	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates after 60 mins by liquid scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates after 60 mins by liquid scintillation counting	ChEMBL	471	7	0	6	6.4	Fc1ccc2c(C3CCN(CCCOc4ccc(-c5nc6ccccc6o5)cc4)CC3)noc2c1	10.1016/j.bmcl.2015.09.045
		CHEMBL3634813	124287	0	None	-2	5	Guinea pig	7.3	pKi	=	7.3	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates after 60 mins by liquid scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates after 60 mins by liquid scintillation counting	ChEMBL	471	7	0	6	6.4	Fc1ccc2c(C3CCN(CCCOc4ccc(-c5nc6ccccc6o5)cc4)CC3)noc2c1	10.1016/j.bmcl.2015.09.045
		46929554	16754	0	None	-31	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	349	5	1	3	4.7	FC(F)(F)c1ccc(SCC(c2ccncc2)c2c[nH]cn2)cc1	10.1021/jm100643t
		CHEMBL1243367	16754	0	None	-31	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	349	5	1	3	4.7	FC(F)(F)c1ccc(SCC(c2ccncc2)c2c[nH]cn2)cc1	10.1021/jm100643t
		1854	3552	7	None	-	1	Rat	5.3	pKi	=	5.3	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	355	1	0	3	3.1	Clc1ccc2c(c1)CCc1c(C2N2CCN(CC2)C(=O)C)nccc1	10.1016/s0960-894x(98)00626-x
		9950564	3552	7	None	-	1	Rat	5.3	pKi	=	5.3	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	355	1	0	3	3.1	Clc1ccc2c(c1)CCc1c(C2N2CCN(CC2)C(=O)C)nccc1	10.1016/s0960-894x(98)00626-x
		CHEMBL326821	3552	7	None	-	1	Rat	5.3	pKi	=	5.3	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	355	1	0	3	3.1	Clc1ccc2c(c1)CCc1c(C2N2CCN(CC2)C(=O)C)nccc1	10.1016/s0960-894x(98)00626-x
		141485889	171198	0	None	-	1	Guinea pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysisDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysis	ChEMBL	290	7	0	3	2.4	CCN(CC)CCCOc1ccc2c(c1)C(=O)N(C)CC2	10.1016/j.bmcl.2019.04.015
		CHEMBL4459304	171198	0	None	-	1	Guinea pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysisDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysis	ChEMBL	290	7	0	3	2.4	CCN(CC)CCCOc1ccc2c(c1)C(=O)N(C)CC2	10.1016/j.bmcl.2019.04.015
		9906447	195577	2	None	-7585	13	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human recombinant H1 receptorBinding affinity to human recombinant H1 receptor	ChEMBL	351	5	0	3	4.8	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc(F)cc3)ccc2o1	10.1021/jm201690h
		CHEMBL2031738	195577	2	None	-7585	13	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human recombinant H1 receptorBinding affinity to human recombinant H1 receptor	ChEMBL	351	5	0	3	4.8	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc(F)cc3)ccc2o1	10.1021/jm201690h
		CHEMBL555146	195577	2	None	-7585	13	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human recombinant H1 receptorBinding affinity to human recombinant H1 receptor	ChEMBL	351	5	0	3	4.8	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc(F)cc3)ccc2o1	10.1021/jm201690h
		25147772	173409	9	None	-6	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	373	4	1	6	3.7	CN1CCN(c2nc(NCc3cccs3)c3cc(Cl)ccc3n2)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL452847	173409	9	None	-6	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	373	4	1	6	3.7	CN1CCN(c2nc(NCc3cccs3)c3cc(Cl)ccc3n2)CC1	10.1016/j.bmcl.2015.12.035
		168274690	190538	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	770	20	6	8	2.3	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5179725	190538	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	770	20	6	8	2.3	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		71681209	90272	0	None	-138	5	Guinea pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysisDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysis	ChEMBL	464	7	0	6	5.7	Cc1c(C)c2ccc(OCCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2oc1=O	10.1021/jm400408r
		CHEMBL2385102	90272	0	None	-138	5	Guinea pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysisDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysis	ChEMBL	464	7	0	6	5.7	Cc1c(C)c2ccc(OCCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2oc1=O	10.1021/jm400408r
		44304327	200882	0	None	-1380	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	535	11	1	6	4.3	CC(C)(C)OC(=O)N[C@H](Cc1ccccc1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		CHEMBL60143	200882	0	None	-1380	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	535	11	1	6	4.3	CC(C)(C)OC(=O)N[C@H](Cc1ccccc1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		168268716	192762	0	None	-1	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	372	3	4	4	3.5	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NC2CCCCC2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5170276	192762	0	None	-1	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	372	3	4	4	3.5	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NC2CCCCC2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221176	192762	0	None	-1	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	372	3	4	4	3.5	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NC2CCCCC2)cc1	10.1021/acs.jmedchem.1c00692
		168274690	190538	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	770	20	6	8	2.3	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5179725	190538	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	770	20	6	8	2.3	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		10051425	204666	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cellsIn vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	494	7	2	5	4.0	NC(=O)N(O)CCC#Cc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)o1	10.1016/j.bmcl.2004.02.005
		CHEMBL73706	204666	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cellsIn vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	494	7	2	5	4.0	NC(=O)N(O)CCC#Cc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)o1	10.1016/j.bmcl.2004.02.005
		44334782	5425	0	None	-1318	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	442	10	1	5	3.4	Cc1ccc(S(=O)(=O)N[C@H]2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)C2)cc1	10.1016/s0960-894x(02)00685-6
		CHEMBL107293	5425	0	None	-1318	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	442	10	1	5	3.4	Cc1ccc(S(=O)(=O)N[C@H]2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)C2)cc1	10.1016/s0960-894x(02)00685-6
		71457844	84076	0	None	-2884	7	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation counting analysisDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation counting analysis	ChEMBL	429	6	0	4	5.1	COc1ccccc1N1CCN(Cc2cc(CN3CCCCC3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		CHEMBL2207638	84076	0	None	-2884	7	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation counting analysisDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation counting analysis	ChEMBL	429	6	0	4	5.1	COc1ccccc1N1CCN(Cc2cc(CN3CCCCC3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		73349359	92543	0	None	-8	8	Human	5.3	pKi	=	5.3	Binding	Inhibition of histamine H1 receptor (unknown origin) by PDSP assayInhibition of histamine H1 receptor (unknown origin) by PDSP assay	ChEMBL	341	6	1	4	2.9	COc1cc(CN[C@H]2C3C4CC5C6C4CC3C6C52)cc(OC)c1OC	10.1016/j.bmc.2013.07.045
		CHEMBL2432051	92543	0	None	-8	8	Human	5.3	pKi	=	5.3	Binding	Inhibition of histamine H1 receptor (unknown origin) by PDSP assayInhibition of histamine H1 receptor (unknown origin) by PDSP assay	ChEMBL	341	6	1	4	2.9	COc1cc(CN[C@H]2C3C4CC5C6C4CC3C6C52)cc(OC)c1OC	10.1016/j.bmc.2013.07.045
		44591012	175580	0	None	-114	6	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	522	10	0	3	6.6	CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
		CHEMBL457957	175580	0	None	-114	6	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	522	10	0	3	6.6	CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
		44304439	102798	0	None	-5	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	436	12	0	4	4.6	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)Cc3ccccc3)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL305338	102798	0	None	-5	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	436	12	0	4	4.6	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)Cc3ccccc3)CC2)cc1	10.1016/s0960-894x(02)00309-8
		44304245	203328	0	None	-13	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	425	11	0	5	4.0	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3cccn3C)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL64884	203328	0	None	-13	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	425	11	0	5	4.0	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3cccn3C)CC2)cc1	10.1016/s0960-894x(02)00309-8
		44334281	4759	0	None	-181	3	Human	4.3	pKi	=	4.3	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	433	9	2	6	2.8	CC(=O)c1ccc(OCCCN2CC[C@H](NC(=O)[C@@H](C)NC(=O)OC(C)(C)C)C2)cc1	10.1016/s0960-894x(02)00685-6
		CHEMBL103828	4759	0	None	-181	3	Human	4.3	pKi	=	4.3	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	433	9	2	6	2.8	CC(=O)c1ccc(OCCCN2CC[C@H](NC(=O)[C@@H](C)NC(=O)OC(C)(C)C)C2)cc1	10.1016/s0960-894x(02)00685-6
		168281024	190915	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	741	19	6	8	1.1	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5185247	190915	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	741	19	6	8	1.1	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		44304459	172600	0	None	-151	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	418	13	0	5	4.8	CCCCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)OCC)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL449040	172600	0	None	-151	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	418	13	0	5	4.8	CCCCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)OCC)CC2)cc1	10.1016/s0960-894x(02)00309-8
		44304283	203173	0	None	-42	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	452	8	0	5	4.8	CCOC(=O)N1CCN(CCCOc2ccc(C(=O)c3ccc(C(C)(C)C)cc3)cc2)CC1	10.1016/s0960-894x(02)00309-8
		CHEMBL64247	203173	0	None	-42	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	452	8	0	5	4.8	CCOC(=O)N1CCN(CCCOc2ccc(C(=O)c3ccc(C(C)(C)C)cc3)cc2)CC1	10.1016/s0960-894x(02)00309-8
		10472082	5141	0	None	-831	4	Human	6.3	pKi	=	6.3	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	334	6	0	3	4.9	C[C@@H]1CC[C@@H](C)N1CCCOc1ccc(-c2ccc(C#N)cc2)cc1	10.1016/s0960-894x(02)00648-0
		CHEMBL105762	5141	0	None	-831	4	Human	6.3	pKi	=	6.3	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	334	6	0	3	4.9	C[C@@H]1CC[C@@H](C)N1CCCOc1ccc(-c2ccc(C#N)cc2)cc1	10.1016/s0960-894x(02)00648-0
		168281024	190915	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	741	19	6	8	1.1	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5185247	190915	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	741	19	6	8	1.1	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		9923186	107542	0	None	-288	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human cortical Histamine 1 receptorBinding affinity at human cortical Histamine 1 receptor	ChEMBL	322	6	1	4	3.1	N#Cc1ccc(-c2ccc(OCCCN3CC[C@H](O)C3)cc2)cc1	10.1016/s0960-894x(02)00648-0
		CHEMBL318801	107542	0	None	-288	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human cortical Histamine 1 receptorBinding affinity at human cortical Histamine 1 receptor	ChEMBL	322	6	1	4	3.1	N#Cc1ccc(-c2ccc(OCCCN3CC[C@H](O)C3)cc2)cc1	10.1016/s0960-894x(02)00648-0
		168273745	192808	0	None	-114	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	332	6	4	4	1.5	N/C(=N\C(=O)NCc1ccccc1)NCCCc1cnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5178472	192808	0	None	-114	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	332	6	4	4	1.5	N/C(=N\C(=O)NCc1ccccc1)NCCCc1cnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221451	192808	0	None	-114	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	332	6	4	4	1.5	N/C(=N\C(=O)NCc1ccccc1)NCCCc1cnc(N)s1	10.1021/acs.jmedchem.1c00692
		2435	3590	83	None	-95	48	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm030480f
		60149	3590	83	None	-95	48	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm030480f
		98	3590	83	None	-95	48	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm030480f
		CHEMBL12713	3590	83	None	-95	48	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm030480f
		DB06144	3590	83	None	-95	48	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm030480f
		44304399	203193	0	None	-28	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	418	13	0	5	4.8	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)OCCCC)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL64317	203193	0	None	-28	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	418	13	0	5	4.8	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)OCCCC)CC2)cc1	10.1016/s0960-894x(02)00309-8
		44335456	4553	0	None	-18	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	336	6	1	4	3.5	N#Cc1ccc(-c2ccc(OCCCN3CCC(O)CC3)cc2)cc1	10.1016/s0960-894x(02)00648-0
		CHEMBL102416	4553	0	None	-18	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	336	6	1	4	3.5	N#Cc1ccc(-c2ccc(OCCCN3CCC(O)CC3)cc2)cc1	10.1016/s0960-894x(02)00648-0
		127036978	137281	0	None	-1	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	415	5	1	6	3.6	COc1ccc(CNc2nc3c(c(N4CCN(C)CC4)n2)CCc2ccccc2-3)cc1	10.1016/j.bmcl.2015.12.035
		CHEMBL3752225	137281	0	None	-1	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	415	5	1	6	3.6	COc1ccc(CNc2nc3c(c(N4CCN(C)CC4)n2)CCc2ccccc2-3)cc1	10.1016/j.bmcl.2015.12.035
		2600	3779	74	None	1	13	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards histamine H1 receptorBinding affinity towards histamine H1 receptor	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1021/jm0205651
		2608	3779	74	None	1	13	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards histamine H1 receptorBinding affinity towards histamine H1 receptor	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1021/jm0205651
		5405	3779	74	None	1	13	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards histamine H1 receptorBinding affinity towards histamine H1 receptor	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1021/jm0205651
		CHEMBL17157	3779	74	None	1	13	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards histamine H1 receptorBinding affinity towards histamine H1 receptor	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1021/jm0205651
		DB00342	3779	74	None	1	13	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards histamine H1 receptorBinding affinity towards histamine H1 receptor	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1021/jm0205651
		10474964	130471	0	None	-181	7	Rat	7.2	pKi	=	7.2	Binding	Inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat cortexInhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat cortex	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
		CHEMBL368061	130471	0	None	-181	7	Rat	7.2	pKi	=	7.2	Binding	Inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat cortexInhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat cortex	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
		CHEMBL5206021	130471	0	None	-181	7	Rat	7.2	pKi	=	7.2	Binding	Inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat cortexInhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat cortex	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
		9827677	168422	0	None	-288	7	Human	7.2	pKi	=	7.2	Binding	Selectivity screen against human Histamine H1 receptorSelectivity screen against human Histamine H1 receptor	ChEMBL	510	7	2	4	4.2	CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1	10.1016/s0960-894x(99)00696-4
		CHEMBL43491	168422	0	None	-288	7	Human	7.2	pKi	=	7.2	Binding	Selectivity screen against human Histamine H1 receptorSelectivity screen against human Histamine H1 receptor	ChEMBL	510	7	2	4	4.2	CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1	10.1016/s0960-894x(99)00696-4
		71212556	143562	0	None	-7	6	Human	7.2	pKi	=	7.2	Binding	Scintillation Proximity Assay: [3H]-Pyrilamine binding experiments are carried out in SPA (scintillation proximity assay) 96-well format. Membranes used in this assay are prepared from HEK-293 cells stably expressing recombinant H1 receptor (human). The incubation is initiated by the addition of a mixture of WGA PVT SPA beads (1 mg/well, Perkin Elmer (MA, USA) RPNQ0001) and 3 μg membranes to assay buffer (67 mM Tris; pH 7.6) containing 3.5 nM [3H]-Pyrilamine and varying concentrations of the test compound (10 point concentration response curves). Non-specific binding is determined in the presence of 10 μM Triprolidine. Samples are incubated for 4 hr. at room temperature (22° C.) and then read in a Microbeta Trilux.Scintillation Proximity Assay: [3H]-Pyrilamine binding experiments are carried out in SPA (scintillation proximity assay) 96-well format. Membranes used in this assay are prepared from HEK-293 cells stably expressing recombinant H1 receptor (human). The incubation is initiated by the addition of a mixture of WGA PVT SPA beads (1 mg/well, Perkin Elmer (MA, USA) RPNQ0001) and 3 μg membranes to assay buffer (67 mM Tris; pH 7.6) containing 3.5 nM [3H]-Pyrilamine and varying concentrations of the test compound (10 point concentration response curves). Non-specific binding is determined in the presence of 10 μM Triprolidine. Samples are incubated for 4 hr. at room temperature (22° C.) and then read in a Microbeta Trilux.	ChEMBL	433	3	1	6	4.6	Cc1ccc2c(c1)Oc1sc(Cl)cc1C(N1CCN(CC(C)(C)C(=O)O)CC1)=N2	nan
		CHEMBL3899169	143562	0	None	-7	6	Human	7.2	pKi	=	7.2	Binding	Scintillation Proximity Assay: [3H]-Pyrilamine binding experiments are carried out in SPA (scintillation proximity assay) 96-well format. Membranes used in this assay are prepared from HEK-293 cells stably expressing recombinant H1 receptor (human). The incubation is initiated by the addition of a mixture of WGA PVT SPA beads (1 mg/well, Perkin Elmer (MA, USA) RPNQ0001) and 3 μg membranes to assay buffer (67 mM Tris; pH 7.6) containing 3.5 nM [3H]-Pyrilamine and varying concentrations of the test compound (10 point concentration response curves). Non-specific binding is determined in the presence of 10 μM Triprolidine. Samples are incubated for 4 hr. at room temperature (22° C.) and then read in a Microbeta Trilux.Scintillation Proximity Assay: [3H]-Pyrilamine binding experiments are carried out in SPA (scintillation proximity assay) 96-well format. Membranes used in this assay are prepared from HEK-293 cells stably expressing recombinant H1 receptor (human). The incubation is initiated by the addition of a mixture of WGA PVT SPA beads (1 mg/well, Perkin Elmer (MA, USA) RPNQ0001) and 3 μg membranes to assay buffer (67 mM Tris; pH 7.6) containing 3.5 nM [3H]-Pyrilamine and varying concentrations of the test compound (10 point concentration response curves). Non-specific binding is determined in the presence of 10 μM Triprolidine. Samples are incubated for 4 hr. at room temperature (22° C.) and then read in a Microbeta Trilux.	ChEMBL	433	3	1	6	4.6	Cc1ccc2c(c1)Oc1sc(Cl)cc1C(N1CCN(CC(C)(C)C(=O)O)CC1)=N2	nan
		51002362	82622	0	None	3	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	448	5	1	7	3.8	COc1ccc(S(=O)(=O)n2cc(C)c3cc(Cl)cnc32)cc1NC1CCN(C)CC1	10.1021/jm300955x
		CHEMBL2179222	82622	0	None	3	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	448	5	1	7	3.8	COc1ccc(S(=O)(=O)n2cc(C)c3cc(Cl)cnc32)cc1NC1CCN(C)CC1	10.1021/jm300955x
		164618283	184544	0	None	-158	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	390	7	4	5	2.4	COc1ccc(C(C)NC(=O)/N=C(\N)NCCCc2sc(N)nc2C)cc1	10.1016/j.ejmech.2021.113190
		CHEMBL4848026	184544	0	None	-158	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	390	7	4	5	2.4	COc1ccc(C(C)NC(=O)/N=C(\N)NCCCc2sc(N)nc2C)cc1	10.1016/j.ejmech.2021.113190
		164614645	185132	0	None	-57	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	402	8	4	4	3.0	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(c1ccccc1)C(C)C	10.1016/j.ejmech.2021.113190
		CHEMBL4856572	185132	0	None	-57	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	402	8	4	4	3.0	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(c1ccccc1)C(C)C	10.1016/j.ejmech.2021.113190
		11530223	8149	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	340	6	0	4	4.6	COc1cccc(C(C)c2c(CCN(C)C)sc3ccccc23)n1	10.1016/j.bmcl.2010.01.134
		CHEMBL1091792	8149	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	340	6	0	4	4.6	COc1cccc(C(C)c2c(CCN(C)C)sc3ccccc23)n1	10.1016/j.bmcl.2010.01.134
		45273828	195834	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	374	4	0	4	4.9	Fc1ccc(Cn2c(N3CCC(n4cccc4)CC3)nc3ccccc32)cc1	10.1016/j.bmcl.2009.05.086
		CHEMBL558339	195834	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	374	4	0	4	4.9	Fc1ccc(Cn2c(N3CCC(n4cccc4)CC3)nc3ccccc32)cc1	10.1016/j.bmcl.2009.05.086
		10343536	4962	0	None	-3715	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	446	10	1	5	3.2	O=C(c1ccc(OCCCN2CC[C@H](NS(=O)(=O)c3cccc(F)c3)C2)cc1)C1CC1	10.1016/s0960-894x(02)00685-6
		CHEMBL104809	4962	0	None	-3715	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	446	10	1	5	3.2	O=C(c1ccc(OCCCN2CC[C@H](NS(=O)(=O)c3cccc(F)c3)C2)cc1)C1CC1	10.1016/s0960-894x(02)00685-6
		132060746	163070	0	None	-3	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-Pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	405	4	0	4	4.4	O=C(OCc1ccccc1)N1Cc2ccc(N3CCN(C4CCCC4)CC3)cc2C1	10.1016/j.ejmech.2018.02.024
		CHEMBL4176474	163070	0	None	-3	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-Pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	405	4	0	4	4.4	O=C(OCc1ccccc1)N1Cc2ccc(N3CCN(C4CCCC4)CC3)cc2C1	10.1016/j.ejmech.2018.02.024
		91864602	140738	0	None	-169	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	313	5	0	2	4.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3818047	140738	0	None	-169	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	313	5	0	2	4.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.05.053
		44301676	199197	0	None	8	2	Rat	8.2	pKi	=	8.2	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	ChEMBL	396	11	1	3	5.3	CN(CCCCCc1c[nH]cn1)CCC(c1ccc(Cl)cc1)c1ccccn1	10.1016/s0960-894x(03)00357-3
		CHEMBL58973	199197	0	None	8	2	Rat	8.2	pKi	=	8.2	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	ChEMBL	396	11	1	3	5.3	CN(CCCCCc1c[nH]cn1)CCC(c1ccc(Cl)cc1)c1ccccn1	10.1016/s0960-894x(03)00357-3
		44326357	111609	0	None	2	3	Human	8.2	pKi	=	8.2	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	308	2	0	3	3.9	CN(C)CC1C[C@@H]2c3ccccc3N(C)c3ccccc3[C@H]2O1	10.1016/j.bmcl.2004.03.069
		CHEMBL328356	111609	0	None	2	3	Human	8.2	pKi	=	8.2	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	308	2	0	3	3.9	CN(C)CC1C[C@@H]2c3ccccc3N(C)c3ccccc3[C@H]2O1	10.1016/j.bmcl.2004.03.069
		5074	3332	80	None	-10	30	Guinea pig	8.2	pKi	=	8.2	Binding	Binding constant against histamine H1 receptor (in vitro)Binding constant against histamine H1 receptor (in vitro)	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm00112a025
		97	3332	80	None	-10	30	Guinea pig	8.2	pKi	=	8.2	Binding	Binding constant against histamine H1 receptor (in vitro)Binding constant against histamine H1 receptor (in vitro)	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm00112a025
		CHEMBL267777	3332	80	None	-10	30	Guinea pig	8.2	pKi	=	8.2	Binding	Binding constant against histamine H1 receptor (in vitro)Binding constant against histamine H1 receptor (in vitro)	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm00112a025
		DB12693	3332	80	None	-10	30	Guinea pig	8.2	pKi	=	8.2	Binding	Binding constant against histamine H1 receptor (in vitro)Binding constant against histamine H1 receptor (in vitro)	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm00112a025
		44521013	199793	0	None	13	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cellsDisplacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cells	ChEMBL	251	3	0	1	3.7	CN(C)CCC1c2ccccc2Cc2ccccc21	10.1016/j.bmc.2009.08.016
		CHEMBL593988	199793	0	None	13	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cellsDisplacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cells	ChEMBL	251	3	0	1	3.7	CN(C)CCC1c2ccccc2Cc2ccccc21	10.1016/j.bmc.2009.08.016
		23722970	69020	21	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	267	4	1	2	3.4	c1ccc(Cc2ccccc2OC2CCNCC2)cc1	10.1021/jm2011589
		CHEMBL1923521	69020	21	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	267	4	1	2	3.4	c1ccc(Cc2ccccc2OC2CCNCC2)cc1	10.1021/jm2011589
		CHEMBL3977546	69020	21	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	267	4	1	2	3.4	c1ccc(Cc2ccccc2OC2CCNCC2)cc1	10.1021/jm2011589
		135515431	4247	34	None	3	3	Human	8.2	pKi	=	8.2	Binding	In vitro binding affinity of compound against histamine H1 neuronal receptorIn vitro binding affinity of compound against histamine H1 neuronal receptor	ChEMBL	328	1	2	6	2.6	CN1CCN(C2=Nc3ccccc3Nc3sc(CO)cc32)CC1	10.1016/S0960-894X(96)00567-7
		CHEMBL100454	4247	34	None	3	3	Human	8.2	pKi	=	8.2	Binding	In vitro binding affinity of compound against histamine H1 neuronal receptorIn vitro binding affinity of compound against histamine H1 neuronal receptor	ChEMBL	328	1	2	6	2.6	CN1CCN(C2=Nc3ccccc3Nc3sc(CO)cc32)CC1	10.1016/S0960-894X(96)00567-7
		15749430	102513	0	None	-	1	Guinea pig	8.2	pKi	=	8.2	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	337	5	1	3	4.1	CN(C)CCC/C=C1\c2ccccc2COc2ccc(C(=O)O)cc21	10.1021/jm00089a020
		CHEMBL304042	102513	0	None	-	1	Guinea pig	8.2	pKi	=	8.2	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	337	5	1	3	4.1	CN(C)CCC/C=C1\c2ccccc2COc2ccc(C(=O)O)cc21	10.1021/jm00089a020
		69262172	81293	1	None	-3	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	462	6	1	4	5.5	O=C(O)c1ccccc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158822	81293	1	None	-3	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	462	6	1	4	5.5	O=C(O)c1ccccc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		59296010	84214	0	None	-3	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	490	7	3	6	2.9	O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1n[nH]c(=O)c2ccccc12	10.1016/j.bmcl.2012.09.113
		CHEMBL2208431	84214	0	None	-3	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	490	7	3	6	2.9	O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1n[nH]c(=O)c2ccccc12	10.1016/j.bmcl.2012.09.113
		59295958	84012	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	507	7	3	5	3.6	O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2ccc(F)cc12	10.1016/j.bmcl.2012.09.112
		CHEMBL2207280	84012	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	507	7	3	5	3.6	O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2ccc(F)cc12	10.1016/j.bmcl.2012.09.112
		23722970	69020	21	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	267	4	1	2	3.4	c1ccc(Cc2ccccc2OC2CCNCC2)cc1	10.1021/jm2011589
		CHEMBL1923521	69020	21	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	267	4	1	2	3.4	c1ccc(Cc2ccccc2OC2CCNCC2)cc1	10.1021/jm2011589
		CHEMBL3977546	69020	21	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	267	4	1	2	3.4	c1ccc(Cc2ccccc2OC2CCNCC2)cc1	10.1021/jm2011589
		134132469	154561	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	301	4	1	2	4.1	Clc1ccc(Cc2ccccc2OC2CCNCC2)cc1	10.1021/acs.jmedchem.6b00981
		CHEMBL3910939	154561	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	301	4	1	2	4.1	Clc1ccc(Cc2ccccc2OC2CCNCC2)cc1	10.1021/acs.jmedchem.6b00981
		CHEMBL3991161	154561	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	301	4	1	2	4.1	Clc1ccc(Cc2ccccc2OC2CCNCC2)cc1	10.1021/acs.jmedchem.6b00981
		134155595	154595	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	267	6	0	2	3.4	c1ccc(Cc2ccccc2OCCN2CCC2)cc1	10.1021/acs.jmedchem.6b00981
		CHEMBL3962094	154595	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	267	6	0	2	3.4	c1ccc(Cc2ccccc2OCCN2CCC2)cc1	10.1021/acs.jmedchem.6b00981
		CHEMBL3991444	154595	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	267	6	0	2	3.4	c1ccc(Cc2ccccc2OCCN2CCC2)cc1	10.1021/acs.jmedchem.6b00981
		135398745	2914	112	None	-2	65	Guinea pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm070516u
		47	2914	112	None	-2	65	Guinea pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm070516u
		CHEMBL715	2914	112	None	-2	65	Guinea pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm070516u
		DB00334	2914	112	None	-2	65	Guinea pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm070516u
		11291	98796	25	None	4	2	Guinea pig	8.2	pKi	=	8.2	Binding	Inhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 minInhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 min	ChEMBL	261	1	0	1	3.9	CN1CCC2=C(C1)C(c1ccccc1)c1ccccc12	10.1021/jm00017a019
		CHEMBL278398	98796	25	None	4	2	Guinea pig	8.2	pKi	=	8.2	Binding	Inhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 minInhibition of [3H]mepyramine binding with histamine H1 receptor in guinea pig cerebellum membranes after 30 min	ChEMBL	261	1	0	1	3.9	CN1CCC2=C(C1)C(c1ccccc1)c1ccccc12	10.1021/jm00017a019
		5255691	11014	1	None	-	1	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	313	1	1	3	2.8	Clc1ccc2c(c1)CCc1cccnc1C2N1CCNCC1	10.1016/s0960-894x(98)00626-x
		CHEMBL117406	11014	1	None	-	1	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	313	1	1	3	2.8	Clc1ccc2c(c1)CCc1cccnc1C2N1CCNCC1	10.1016/s0960-894x(98)00626-x
		44343920	12790	0	None	-	1	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	327	1	0	3	3.2	CN1CCN(C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/s0960-894x(98)00626-x
		CHEMBL118807	12790	0	None	-	1	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	327	1	0	3	3.2	CN1CCN(C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/s0960-894x(98)00626-x
		155554396	174617	0	None	158	2	Guinea pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysisDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysis	ChEMBL	304	5	0	4	1.4	CN1CCc2ccc(OCCCN3CCOCC3)cc2C1=O	10.1016/j.bmcl.2019.04.015
		CHEMBL4557586	174617	0	None	158	2	Guinea pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysisDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysis	ChEMBL	304	5	0	4	1.4	CN1CCc2ccc(OCCCN3CCOCC3)cc2C1=O	10.1016/j.bmcl.2019.04.015
		45270339	195398	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	406	4	0	4	4.2	O=C1CCCCN1C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1	10.1016/j.bmcl.2009.05.086
		CHEMBL552026	195398	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	406	4	0	4	4.2	O=C1CCCCN1C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1	10.1016/j.bmcl.2009.05.086
		11393666	192986	0	None	-16	19	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]pyrilamine from recombinant human H1 receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]pyrilamine from recombinant human H1 receptor measured after 60 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
		CHEMBL5201983	192986	0	None	-16	19	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]pyrilamine from recombinant human H1 receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]pyrilamine from recombinant human H1 receptor measured after 60 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
		CHEMBL5222597	192986	0	None	-16	19	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]pyrilamine from recombinant human H1 receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]pyrilamine from recombinant human H1 receptor measured after 60 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
		53322838	57762	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	375	7	0	4	5.2	C[C@H](C1=C(CCN(C)Cc2cccs2)Cc2ccccc21)c1cnccn1	10.1016/j.bmcl.2010.12.053
		CHEMBL1669419	57762	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	375	7	0	4	5.2	C[C@H](C1=C(CCN(C)Cc2cccs2)Cc2ccccc21)c1cnccn1	10.1016/j.bmcl.2010.12.053
		135398737	958	93	None	-2	89	Guinea pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenate after 60 mins by liquid scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenate after 60 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2014.01.012
		38	958	93	None	-2	89	Guinea pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenate after 60 mins by liquid scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenate after 60 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2014.01.012
		722	958	93	None	-2	89	Guinea pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenate after 60 mins by liquid scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenate after 60 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2014.01.012
		CHEMBL42	958	93	None	-2	89	Guinea pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenate after 60 mins by liquid scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenate after 60 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2014.01.012
		DB00363	958	93	None	-2	89	Guinea pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenate after 60 mins by liquid scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenate after 60 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2014.01.012
		45272895	195657	18	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	389	4	0	5	4.6	Cc1cnn(C2CCN(c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)c1	10.1016/j.bmcl.2009.05.086
		CHEMBL556450	195657	18	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	389	4	0	5	4.6	Cc1cnn(C2CCN(c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)c1	10.1016/j.bmcl.2009.05.086
		45272895	195657	18	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation counting	ChEMBL	389	4	0	5	4.6	Cc1cnn(C2CCN(c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)c1	10.1016/j.bmcl.2010.03.027
		CHEMBL556450	195657	18	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation counting	ChEMBL	389	4	0	5	4.6	Cc1cnn(C2CCN(c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)c1	10.1016/j.bmcl.2010.03.027
		9980189	115227	0	None	-	1	Guinea pig	8.2	pKi	=	8.2	Binding	Inhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptorInhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptor	ChEMBL	431	5	1	4	5.2	O=C(O)c1ccc2c(c1)C(SCCN1CCc3ccccc3C1)c1ccccc1CO2	10.1021/jm00055a013
		CHEMBL334678	115227	0	None	-	1	Guinea pig	8.2	pKi	=	8.2	Binding	Inhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptorInhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptor	ChEMBL	431	5	1	4	5.2	O=C(O)c1ccc2c(c1)C(SCCN1CCc3ccccc3C1)c1ccccc1CO2	10.1021/jm00055a013
		44304402	201212	0	None	-3	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	415	12	0	6	4.5	CCCCCC(=O)c1ccc(OCCCN2CCN(Cc3nccs3)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL60360	201212	0	None	-3	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	415	12	0	6	4.5	CCCCCC(=O)c1ccc(OCCCN2CCN(Cc3nccs3)CC2)cc1	10.1016/s0960-894x(02)00309-8
		23562970	100913	0	None	-10	2	Rat	6.2	pKi	=	6.2	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	ChEMBL	340	8	2	3	3.8	Clc1ccc(C(CCNCCc2c[nH]cn2)c2ccccn2)cc1	10.1016/s0960-894x(03)00357-3
		CHEMBL293895	100913	0	None	-10	2	Rat	6.2	pKi	=	6.2	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	ChEMBL	340	8	2	3	3.8	Clc1ccc(C(CCNCCc2c[nH]cn2)c2ccccn2)cc1	10.1016/s0960-894x(03)00357-3
		1204	1932	119	None	-501	24	Human	5.2	pKi	=	5.2	Binding	Binding affinity to histamine H1 receptor (unknown origin)Binding affinity to histamine H1 receptor (unknown origin)	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		1247	1932	119	None	-501	24	Human	5.2	pKi	=	5.2	Binding	Binding affinity to histamine H1 receptor (unknown origin)Binding affinity to histamine H1 receptor (unknown origin)	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		1375	1932	119	None	-501	24	Human	5.2	pKi	=	5.2	Binding	Binding affinity to histamine H1 receptor (unknown origin)Binding affinity to histamine H1 receptor (unknown origin)	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		774	1932	119	None	-501	24	Human	5.2	pKi	=	5.2	Binding	Binding affinity to histamine H1 receptor (unknown origin)Binding affinity to histamine H1 receptor (unknown origin)	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		CHEMBL90	1932	119	None	-501	24	Human	5.2	pKi	=	5.2	Binding	Binding affinity to histamine H1 receptor (unknown origin)Binding affinity to histamine H1 receptor (unknown origin)	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		DB05381	1932	119	None	-501	24	Human	5.2	pKi	=	5.2	Binding	Binding affinity to histamine H1 receptor (unknown origin)Binding affinity to histamine H1 receptor (unknown origin)	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1021/acs.jmedchem.5b00516
		10339767	53188	0	None	-602	3	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptorDisplacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptor	ChEMBL	380	6	0	4	4.8	Cn1c(=O)sc2cc(CCCCN3CCC(c4ccccc4)CC3)ccc21	10.1016/s0960-894x(02)00123-3
		CHEMBL15986	53188	0	None	-602	3	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptorDisplacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptor	ChEMBL	380	6	0	4	4.8	Cn1c(=O)sc2cc(CCCCN3CCC(c4ccccc4)CC3)ccc21	10.1016/s0960-894x(02)00123-3
		44333987	108549	0	None	-66	3	Human	4.2	pKi	=	4.2	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	433	9	2	6	2.8	CC(=O)c1ccc(OCCCN2CC[C@H](NC(=O)[C@H](C)NC(=O)OC(C)(C)C)C2)cc1	10.1016/s0960-894x(02)00685-6
		CHEMBL320174	108549	0	None	-66	3	Human	4.2	pKi	=	4.2	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	433	9	2	6	2.8	CC(=O)c1ccc(OCCCN2CC[C@H](NC(=O)[C@H](C)NC(=O)OC(C)(C)C)C2)cc1	10.1016/s0960-894x(02)00685-6
		44304088	202387	0	None	-23	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	402	8	0	5	4.0	CCOC(=O)N1CCN(CCCOc2ccc(C(=O)C3CCCCC3)cc2)CC1	10.1016/s0960-894x(02)00309-8
		CHEMBL61070	202387	0	None	-23	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	402	8	0	5	4.0	CCOC(=O)N1CCN(CCCOc2ccc(C(=O)C3CCCCC3)cc2)CC1	10.1016/s0960-894x(02)00309-8
		91864602	140738	0	None	-169	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	313	5	0	2	4.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3818047	140738	0	None	-169	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	313	5	0	2	4.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.05.053
		57400700	67878	0	None	-83	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	470	8	1	6	3.4	COc1ccc(CN(CCN2CCN(C(=O)c3nc4ccccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		CHEMBL1910380	67878	0	None	-83	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	470	8	1	6	3.4	COc1ccc(CN(CCN2CCN(C(=O)c3nc4ccccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		18539962	102131	0	None	-223	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	318	10	1	4	3.1	CCCCCC(=O)c1ccc(OCCCN2CCNCC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL302445	102131	0	None	-223	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	318	10	1	4	3.1	CCCCCC(=O)c1ccc(OCCCN2CCNCC2)cc1	10.1016/s0960-894x(02)00309-8
		168283321	192895	0	None	-2	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	364	7	4	4	2.3	Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCC(C)C1CCCCC1	10.1021/acs.jmedchem.1c00692
		CHEMBL5183015	192895	0	None	-2	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	364	7	4	4	2.3	Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCC(C)C1CCCCC1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222057	192895	0	None	-2	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	364	7	4	4	2.3	Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCC(C)C1CCCCC1	10.1021/acs.jmedchem.1c00692
		127052293	140238	3	None	-131	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid scintillation counting method	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3805361	140238	3	None	-131	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid scintillation counting method	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		242	470	124	None	-22	51	Human	7.2	pKi	=	7.2	Binding	Binding affinity to H1 histamine receptor (unknown origin)Binding affinity to H1 histamine receptor (unknown origin)	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2020.127681
		34	470	124	None	-22	51	Human	7.2	pKi	=	7.2	Binding	Binding affinity to H1 histamine receptor (unknown origin)Binding affinity to H1 histamine receptor (unknown origin)	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2020.127681
		60795	470	124	None	-22	51	Human	7.2	pKi	=	7.2	Binding	Binding affinity to H1 histamine receptor (unknown origin)Binding affinity to H1 histamine receptor (unknown origin)	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2020.127681
		CHEMBL1112	470	124	None	-22	51	Human	7.2	pKi	=	7.2	Binding	Binding affinity to H1 histamine receptor (unknown origin)Binding affinity to H1 histamine receptor (unknown origin)	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2020.127681
		DB01238	470	124	None	-22	51	Human	7.2	pKi	=	7.2	Binding	Binding affinity to H1 histamine receptor (unknown origin)Binding affinity to H1 histamine receptor (unknown origin)	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2020.127681
		57399432	70465	0	None	-2	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-Pyrilamine from human histamine H1 receptor by liquid scintillation counterDisplacement of [3H]-Pyrilamine from human histamine H1 receptor by liquid scintillation counter	ChEMBL	399	6	0	4	5.5	Clc1ccc(N2CCCN(CCCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.bmc.2012.01.022
		CHEMBL1946254	70465	0	None	-2	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-Pyrilamine from human histamine H1 receptor by liquid scintillation counterDisplacement of [3H]-Pyrilamine from human histamine H1 receptor by liquid scintillation counter	ChEMBL	399	6	0	4	5.5	Clc1ccc(N2CCCN(CCCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.bmc.2012.01.022
		45485462	197686	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation counting	ChEMBL	419	8	1	2	6.6	CC1CCC(CCCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2009.07.047
		CHEMBL571174	197686	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation counting	ChEMBL	419	8	1	2	6.6	CC1CCC(CCCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2009.07.047
		29136870	69021	7	None	46	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	301	2	0	7	0.7	CN1CCN(c2nc(N3CCCC3)c3cnn(C)c3n2)CC1	10.1021/jm2011589
		CHEMBL1923522	69021	7	None	46	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	301	2	0	7	0.7	CN1CCN(c2nc(N3CCCC3)c3cnn(C)c3n2)CC1	10.1021/jm2011589
		289	242	12	None	-56	14	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human histamine H1 receptor by radioligand displacement assayBinding affinity to human histamine H1 receptor by radioligand displacement assay	ChEMBL	301	8	0	2	4.9	CCCCC1CCN(CC1)CCCC(=O)c1ccccc1C	10.1021/jm100697g
		9948320	242	12	None	-56	14	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human histamine H1 receptor by radioligand displacement assayBinding affinity to human histamine H1 receptor by radioligand displacement assay	ChEMBL	301	8	0	2	4.9	CCCCC1CCN(CC1)CCCC(=O)c1ccccc1C	10.1021/jm100697g
		CHEMBL1242950	242	12	None	-56	14	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human histamine H1 receptor by radioligand displacement assayBinding affinity to human histamine H1 receptor by radioligand displacement assay	ChEMBL	301	8	0	2	4.9	CCCCC1CCN(CC1)CCCC(=O)c1ccccc1C	10.1021/jm100697g
		44288877	168599	0	None	-87	5	Human	6.2	pKi	=	6.2	Binding	Selectivity screen against human Histamine H1 receptorSelectivity screen against human Histamine H1 receptor	ChEMBL	549	7	1	5	4.3	CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C	10.1016/s0960-894x(99)00696-4
		CHEMBL43594	168599	0	None	-87	5	Human	6.2	pKi	=	6.2	Binding	Selectivity screen against human Histamine H1 receptorSelectivity screen against human Histamine H1 receptor	ChEMBL	549	7	1	5	4.3	CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C	10.1016/s0960-894x(99)00696-4
		44304031	100672	0	None	-85	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	452	10	0	6	4.1	CCOC(=O)N1CCN(CCCOc2ccc(C(=O)/C=C/c3ccc(OC)cc3)cc2)CC1	10.1016/s0960-894x(02)00309-8
		CHEMBL292275	100672	0	None	-85	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	452	10	0	6	4.1	CCOC(=O)N1CCN(CCCOc2ccc(C(=O)/C=C/c3ccc(OC)cc3)cc2)CC1	10.1016/s0960-894x(02)00309-8
		164611342	185088	0	None	-134	6	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	346	6	4	4	1.8	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCc1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4856005	185088	0	None	-134	6	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	346	6	4	4	1.8	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCc1ccccc1	10.1016/j.ejmech.2021.113190
		3041343	109799	5	None	-10	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	377	6	1	3	3.4	O=C1NC(c2ccccc2)(c2ccccc2)C(=O)N1CCCN1CCCCC1	10.1016/j.ejmech.2014.03.014
		CHEMBL3233067	109799	5	None	-10	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	377	6	1	3	3.4	O=C1NC(c2ccccc2)(c2ccccc2)C(=O)N1CCCN1CCCCC1	10.1016/j.ejmech.2014.03.014
		132060770	162639	0	None	5	10	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-Pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	451	7	0	6	3.5	CCOC(=O)CCN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)CC3)CC1	10.1016/j.ejmech.2018.02.024
		CHEMBL4169689	162639	0	None	5	10	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-Pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	451	7	0	6	3.5	CCOC(=O)CCN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)CC3)CC1	10.1016/j.ejmech.2018.02.024
		29136870	69021	7	None	46	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	301	2	0	7	0.7	CN1CCN(c2nc(N3CCCC3)c3cnn(C)c3n2)CC1	10.1021/jm2011589
		CHEMBL1923522	69021	7	None	46	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	301	2	0	7	0.7	CN1CCN(c2nc(N3CCCC3)c3cnn(C)c3n2)CC1	10.1021/jm2011589
		3069135	70164	3	None	-8	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]pyrilamine from human H1 receptor by liquid scintillation countingDisplacement of [3H]pyrilamine from human H1 receptor by liquid scintillation counting	ChEMBL	314	6	0	3	3.4	Fc1ccc(OCCCN2CCN(c3ccccc3)CC2)cc1	10.1016/j.bmc.2011.12.019
		CHEMBL1940412	70164	3	None	-8	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]pyrilamine from human H1 receptor by liquid scintillation countingDisplacement of [3H]pyrilamine from human H1 receptor by liquid scintillation counting	ChEMBL	314	6	0	3	3.4	Fc1ccc(OCCCN2CCN(c3ccccc3)CC2)cc1	10.1016/j.bmc.2011.12.019
		44334042	163489	0	None	-562	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	453	10	1	6	3.0	N#Cc1ccccc1S(=O)(=O)N[C@H]1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)C1	10.1016/s0960-894x(02)00685-6
		CHEMBL420108	163489	0	None	-562	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	453	10	1	6	3.0	N#Cc1ccccc1S(=O)(=O)N[C@H]1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)C1	10.1016/s0960-894x(02)00685-6
		11848624	89146	0	None	-15	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	381	7	1	6	4.3	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1OC	10.1021/jm701143p
		CHEMBL236587	89146	0	None	-15	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	381	7	1	6	4.3	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1OC	10.1021/jm701143p
		11848624	89146	0	None	-15	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	381	7	1	6	4.3	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1OC	10.1016/j.bmcl.2009.09.024
		CHEMBL236587	89146	0	None	-15	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	381	7	1	6	4.3	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1OC	10.1016/j.bmcl.2009.09.024
		46884637	7723	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	293	5	0	3	3.3	Cc1nccnc1CC1=C(CCN(C)C)Cc2ccccc21	10.1016/j.bmcl.2010.02.055
		CHEMBL1088898	7723	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	293	5	0	3	3.3	Cc1nccnc1CC1=C(CCN(C)C)Cc2ccccc21	10.1016/j.bmcl.2010.02.055
		44288917	100255	0	None	-34	4	Human	7.2	pKi	=	7.2	Binding	Selectivity screen against human Histamine H1 receptorSelectivity screen against human Histamine H1 receptor	ChEMBL	510	7	2	4	4.0	CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1	10.1016/s0960-894x(99)00696-4
		CHEMBL288768	100255	0	None	-34	4	Human	7.2	pKi	=	7.2	Binding	Selectivity screen against human Histamine H1 receptorSelectivity screen against human Histamine H1 receptor	ChEMBL	510	7	2	4	4.0	CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1	10.1016/s0960-894x(99)00696-4
		71072104	81263	0	None	-15	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	520	9	1	5	5.3	COc1ccccc1C[C@@H](C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158775	81263	0	None	-15	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	520	9	1	5	5.3	COc1ccccc1C[C@@H](C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		71460416	81264	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	520	9	1	5	5.3	COc1ccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158776	81264	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	520	9	1	5	5.3	COc1ccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1	10.1016/j.bmcl.2012.08.103
		66615617	81276	0	None	-31	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	504	8	1	4	5.6	Cc1c(OC2CCN(CC3CCN([C@@H](Cc4ccccc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl	10.1016/j.bmcl.2012.08.103
		CHEMBL2158788	81276	0	None	-31	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	504	8	1	4	5.6	Cc1c(OC2CCN(CC3CCN([C@@H](Cc4ccccc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl	10.1016/j.bmcl.2012.08.103
		10151756	81286	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	462	6	1	4	5.1	O=C(O)C(c1ccccc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158815	81286	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	462	6	1	4	5.1	O=C(O)C(c1ccccc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		68846936	81287	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	476	7	1	4	5.4	O=C(O)C(c1ccccc1)N1CCCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)C1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158816	81287	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	476	7	1	4	5.4	O=C(O)C(c1ccccc1)N1CCCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)C1	10.1016/j.bmcl.2012.08.103
		69260851	81295	1	None	2	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	462	6	1	4	5.5	O=C(O)c1ccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158824	81295	1	None	2	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	462	6	1	4	5.5	O=C(O)c1ccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1	10.1016/j.bmcl.2012.08.103
		69347719	81303	1	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	476	7	1	4	5.4	O=C(O)c1ccccc1CN1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158831	81303	1	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	476	7	1	4	5.4	O=C(O)c1ccccc1CN1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		59296039	84210	0	None	-15	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	467	8	3	6	3.2	COc1cc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)ccc1N	10.1016/j.bmcl.2012.09.113
		CHEMBL2208427	84210	0	None	-15	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	467	8	3	6	3.2	COc1cc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)ccc1N	10.1016/j.bmcl.2012.09.113
		59296024	84009	0	None	-9	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	547	8	3	7	2.5	Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3ccc(S(C)(=O)=O)cc23)CC1	10.1016/j.bmcl.2012.09.112
		CHEMBL2207277	84009	0	None	-9	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	547	8	3	7	2.5	Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3ccc(S(C)(=O)=O)cc23)CC1	10.1016/j.bmcl.2012.09.112
		59295928	84015	0	None	-63	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	581	8	3	7	3.2	Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccc(S(C)(=O)=O)cc34)CC2)c1Cl	10.1016/j.bmcl.2012.09.112
		CHEMBL2207283	84015	0	None	-63	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	581	8	3	7	3.2	Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccc(S(C)(=O)=O)cc34)CC2)c1Cl	10.1016/j.bmcl.2012.09.112
		43229249	140817	1	None	-16	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	279	5	0	2	3.7	O=C(CCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2016.05.053
		CHEMBL3818989	140817	1	None	-16	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	279	5	0	2	3.7	O=C(CCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2016.05.053
		1222	881	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor N7.45Q mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor N7.45Q mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/nchembio714
		2678	881	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor N7.45Q mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor N7.45Q mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/nchembio714
		581	881	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor N7.45Q mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor N7.45Q mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/nchembio714
		CHEMBL1000	881	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor N7.45Q mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor N7.45Q mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/nchembio714
		DB00341	881	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor N7.45Q mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor N7.45Q mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/nchembio714
		1222	881	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor N7.45S mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor N7.45S mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/nchembio714
		2678	881	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor N7.45S mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor N7.45S mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/nchembio714
		581	881	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor N7.45S mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor N7.45S mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/nchembio714
		CHEMBL1000	881	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor N7.45S mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor N7.45S mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/nchembio714
		DB00341	881	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor N7.45S mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor N7.45S mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/nchembio714
		134145497	149163	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	309	6	0	2	4.5	c1ccc(Cc2ccccc2OCCN2CCCCCC2)cc1	10.1021/acs.jmedchem.6b00981
		CHEMBL3943575	149163	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	309	6	0	2	4.5	c1ccc(Cc2ccccc2OCCN2CCCCCC2)cc1	10.1021/acs.jmedchem.6b00981
		129103318	167314	0	None	-870	14	Human	6.2	pKi	=	6.2	Binding	Binding affinity to H1 receptor (unknown origin)Binding affinity to H1 receptor (unknown origin)	ChEMBL	475	7	0	5	5.0	O=C(CCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2	10.1016/j.ejmech.2020.112709
		CHEMBL4293999	167314	0	None	-870	14	Human	6.2	pKi	=	6.2	Binding	Binding affinity to H1 receptor (unknown origin)Binding affinity to H1 receptor (unknown origin)	ChEMBL	475	7	0	5	5.0	O=C(CCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2	10.1016/j.ejmech.2020.112709
		129103318	167314	0	None	-870	14	Guinea pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by liquid scintillation countingDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by liquid scintillation counting	ChEMBL	475	7	0	5	5.0	O=C(CCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2	10.1021/acs.jmedchem.8b01096
		CHEMBL4293999	167314	0	None	-870	14	Guinea pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by liquid scintillation countingDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by liquid scintillation counting	ChEMBL	475	7	0	5	5.0	O=C(CCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2	10.1021/acs.jmedchem.8b01096
		10263017	207462	2	None	1	3	Guinea pig	6.2	pKi	=	6.2	Binding	Binding affinity against H1 receptor of guinea pig by the displacement of [3H]mepyramine, bound to membranes of CHO cellsBinding affinity against H1 receptor of guinea pig by the displacement of [3H]mepyramine, bound to membranes of CHO cells	ChEMBL	223	10	2	2	3.0	NCCCCCCCCCCc1c[nH]cn1	10.1021/jm00002a008
		CHEMBL94249	207462	2	None	1	3	Guinea pig	6.2	pKi	=	6.2	Binding	Binding affinity against H1 receptor of guinea pig by the displacement of [3H]mepyramine, bound to membranes of CHO cellsBinding affinity against H1 receptor of guinea pig by the displacement of [3H]mepyramine, bound to membranes of CHO cells	ChEMBL	223	10	2	2	3.0	NCCCCCCCCCCc1c[nH]cn1	10.1021/jm00002a008
		127036982	137467	0	None	3	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	525	6	1	6	5.9	COc1ccc(CNc2nc(N3CCN(C)CC3)nc3c2CCc2ccccc2-3)cc1-c1ccc(Cl)cc1	10.1016/j.bmcl.2015.12.035
		CHEMBL3753784	137467	0	None	3	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	525	6	1	6	5.9	COc1ccc(CNc2nc(N3CCN(C)CC3)nc3c2CCc2ccccc2-3)cc1-c1ccc(Cl)cc1	10.1016/j.bmcl.2015.12.035
		550981	69031	12	None	-2	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	280	5	2	3	2.9	OC(CNC1CC1)Cn1c2ccccc2c2ccccc21	10.1021/jm2011589
		CHEMBL1923533	69031	12	None	-2	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	280	5	2	3	2.9	OC(CNC1CC1)Cn1c2ccccc2c2ccccc21	10.1021/jm2011589
		10805119	54602	0	None	-3235	2	Guinea pig	4.2	pKi	=	4.2	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	313	5	2	3	3.6	O=C(Nc1cccc(C(F)(F)F)c1)OCCCc1c[nH]cn1	10.1021/jm9507688
		CHEMBL16108	54602	0	None	-3235	2	Guinea pig	4.2	pKi	=	4.2	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	313	5	2	3	3.6	O=C(Nc1cccc(C(F)(F)F)c1)OCCCc1c[nH]cn1	10.1021/jm9507688
		10062176	55835	0	None	-15488	2	Guinea pig	4.2	pKi	=	4.2	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	279	5	2	3	3.2	O=C(Nc1ccc(Cl)cc1)OCCCc1c[nH]cn1	10.1021/jm9507688
		CHEMBL16231	55835	0	None	-15488	2	Guinea pig	4.2	pKi	=	4.2	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	279	5	2	3	3.2	O=C(Nc1ccc(Cl)cc1)OCCCc1c[nH]cn1	10.1021/jm9507688
		10612308	98211	0	None	-6309	2	Guinea pig	4.2	pKi	=	4.2	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	273	7	2	3	2.3	O=C(NCCc1ccccc1)OCCCc1c[nH]cn1	10.1021/jm9507688
		CHEMBL274262	98211	0	None	-6309	2	Guinea pig	4.2	pKi	=	4.2	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	273	7	2	3	2.3	O=C(NCCc1ccccc1)OCCCc1c[nH]cn1	10.1021/jm9507688
		164612760	184718	0	None	-54	4	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	390	7	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=S)NC[C@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4850490	184718	0	None	-54	4	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	390	7	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=S)NC[C@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		13091273	182438	0	None	-275	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	367	6	1	3	4.3	O=C(CCCN1C2CCC1CC(O)(c1ccccc1)C2)c1ccc(F)cc1	10.1016/j.bmc.2008.06.030
		CHEMBL478617	182438	0	None	-275	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	367	6	1	3	4.3	O=C(CCCN1C2CCC1CC(O)(c1ccccc1)C2)c1ccc(F)cc1	10.1016/j.bmc.2008.06.030
		CHEMBL553327	182438	0	None	-275	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	367	6	1	3	4.3	O=C(CCCN1C2CCC1CC(O)(c1ccccc1)C2)c1ccc(F)cc1	10.1016/j.bmc.2008.06.030
		119812	199730	65	None	23	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cellsDisplacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cells	ChEMBL	225	5	1	1	3.4	CNCCC(c1ccccc1)c1ccccc1	10.1016/j.bmc.2009.08.016
		CHEMBL593494	199730	65	None	23	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cellsDisplacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cells	ChEMBL	225	5	1	1	3.4	CNCCC(c1ccccc1)c1ccccc1	10.1016/j.bmc.2009.08.016
		9932698	17909	0	None	-354	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsDisplacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	435	6	2	4	3.4	NCc1ccc2c(c1)c(C1CCN(CCN3CCNC3=O)CC1)cn2-c1ccc(F)cc1	10.1021/jm100652h
		CHEMBL1259172	17909	0	None	-354	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsDisplacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	435	6	2	4	3.4	NCc1ccc2c(c1)c(C1CCN(CCN3CCNC3=O)CC1)cn2-c1ccc(F)cc1	10.1021/jm100652h
		52946023	17914	0	None	-95	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsDisplacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	477	7	2	4	3.6	CC(=O)NCc1ccc2c(c1)c(C1CCN(CCN3CCNC3=O)CC1)cn2-c1ccc(F)cc1	10.1021/jm100652h
		CHEMBL1259187	17914	0	None	-95	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsDisplacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	477	7	2	4	3.6	CC(=O)NCc1ccc2c(c1)c(C1CCN(CCN3CCNC3=O)CC1)cn2-c1ccc(F)cc1	10.1021/jm100652h
		45485529	197718	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation counting	ChEMBL	385	6	1	2	5.2	Cc1ccc(CCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1	10.1016/j.bmcl.2009.07.047
		CHEMBL571391	197718	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation counting	ChEMBL	385	6	1	2	5.2	Cc1ccc(CCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1	10.1016/j.bmcl.2009.07.047
		49841845	69739	0	None	-1288	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human H1 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H1 receptor expressed in HEK cell membranes	ChEMBL	309	2	1	6	2.2	CN1CCN(c2nc(N)nc3cc(-c4ccco4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935573	69739	0	None	-1288	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]histamine from human H1 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H1 receptor expressed in HEK cell membranes	ChEMBL	309	2	1	6	2.2	CN1CCN(c2nc(N)nc3cc(-c4ccco4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
		168294767	193019	0	None	-3235	20	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5207281	193019	0	None	-3235	20	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222802	193019	0	None	-3235	20	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		71454294	84077	0	None	-1412	7	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation counting analysisDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation counting analysis	ChEMBL	431	6	0	5	4.0	COc1ccccc1N1CCN(Cc2cc(CN3CCOCC3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		CHEMBL2207639	84077	0	None	-1412	7	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation counting analysisDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation counting analysis	ChEMBL	431	6	0	5	4.0	COc1ccccc1N1CCN(Cc2cc(CN3CCOCC3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		6918107	78146	16	None	-7	5	Rat	5.2	pKi	=	5.2	Binding	The binding affinity was measured on histamine H1 receptor using [3H]- mepyramine as radioligand.The binding affinity was measured on histamine H1 receptor using [3H]- mepyramine as radioligand.	ChEMBL	319	2	0	4	3.5	Cc1nccn1C[C@H]1CCc2c(c3cccc4c3n2CCC4)C1=O	10.1021/jm00075a026
		CHEMBL2103778	78146	16	None	-7	5	Rat	5.2	pKi	=	5.2	Binding	The binding affinity was measured on histamine H1 receptor using [3H]- mepyramine as radioligand.The binding affinity was measured on histamine H1 receptor using [3H]- mepyramine as radioligand.	ChEMBL	319	2	0	4	3.5	Cc1nccn1C[C@H]1CCc2c(c3cccc4c3n2CCC4)C1=O	10.1021/jm00075a026
		127052293	140238	3	None	-131	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid scintillation counting method	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3805361	140238	3	None	-131	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid scintillation counting method	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		15723	18539	111	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation counting	ChEMBL	267	3	2	2	2.9	OC(c1ccccc1)(c1ccccc1)C1CCNCC1	10.1016/j.bmcl.2009.07.047
		CHEMBL127508	18539	111	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation counting	ChEMBL	267	3	2	2	2.9	OC(c1ccccc1)(c1ccccc1)C1CCNCC1	10.1016/j.bmcl.2009.07.047
		44312568	204773	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cellsIn vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	498	7	2	5	3.4	NC(=O)N(O)CCC#C[C@@H]1CC[C@@H](CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)O1	10.1016/j.bmcl.2004.02.005
		CHEMBL74779	204773	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cellsIn vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	498	7	2	5	3.4	NC(=O)N(O)CCC#C[C@@H]1CC[C@@H](CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)O1	10.1016/j.bmcl.2004.02.005
		44304243	203199	0	None	-48	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	374	13	0	4	4.6	CCCCCC(=O)c1ccc(OCCCN2CCN(CCCC)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL64334	203199	0	None	-48	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	374	13	0	4	4.6	CCCCCC(=O)c1ccc(OCCCN2CCN(CCCC)CC2)cc1	10.1016/s0960-894x(02)00309-8
		10003483	4644	0	None	-2454	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	442	10	1	5	3.4	Cc1cccc(S(=O)(=O)N[C@H]2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)C2)c1	10.1016/s0960-894x(02)00685-6
		CHEMBL103027	4644	0	None	-2454	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	442	10	1	5	3.4	Cc1cccc(S(=O)(=O)N[C@H]2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)C2)c1	10.1016/s0960-894x(02)00685-6
		168294161	193006	0	None	-3	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	360	6	4	4	3.3	CCCCCNC(=O)/N=C(\N)Nc1cccc(-c2sc(N)nc2C)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5204739	193006	0	None	-3	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	360	6	4	4	3.3	CCCCCNC(=O)/N=C(\N)Nc1cccc(-c2sc(N)nc2C)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222742	193006	0	None	-3	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	360	6	4	4	3.3	CCCCCNC(=O)/N=C(\N)Nc1cccc(-c2sc(N)nc2C)c1	10.1021/acs.jmedchem.1c00692
		57390694	70466	0	None	-3	6	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-Pyrilamine from human histamine H1 receptor by liquid scintillation counterDisplacement of [3H]-Pyrilamine from human histamine H1 receptor by liquid scintillation counter	ChEMBL	385	5	0	4	5.1	Clc1ccc(N2CCCN(CCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.bmc.2012.01.022
		CHEMBL1946255	70466	0	None	-3	6	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-Pyrilamine from human histamine H1 receptor by liquid scintillation counterDisplacement of [3H]-Pyrilamine from human histamine H1 receptor by liquid scintillation counter	ChEMBL	385	5	0	4	5.1	Clc1ccc(N2CCCN(CCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.bmc.2012.01.022
		44582705	186996	0	None	-4	13	Human	6.2	pKi	=	6.2	Binding	Inhibition of human cloned histamine H1 receptor by competitive binding experimentInhibition of human cloned histamine H1 receptor by competitive binding experiment	ChEMBL	399	9	0	4	4.5	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
		CHEMBL490632	186996	0	None	-4	13	Human	6.2	pKi	=	6.2	Binding	Inhibition of human cloned histamine H1 receptor by competitive binding experimentInhibition of human cloned histamine H1 receptor by competitive binding experiment	ChEMBL	399	9	0	4	4.5	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
		3050372	70166	7	None	-15	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]pyrilamine from human H1 receptor by liquid scintillation countingDisplacement of [3H]pyrilamine from human H1 receptor by liquid scintillation counting	ChEMBL	296	6	0	3	3.3	c1ccc(OCCCN2CCN(c3ccccc3)CC2)cc1	10.1016/j.bmc.2011.12.019
		CHEMBL1940414	70166	7	None	-15	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]pyrilamine from human H1 receptor by liquid scintillation countingDisplacement of [3H]pyrilamine from human H1 receptor by liquid scintillation counting	ChEMBL	296	6	0	3	3.3	c1ccc(OCCCN2CCN(c3ccccc3)CC2)cc1	10.1016/j.bmc.2011.12.019
		127036186	137414	0	None	-21	19	Human	6.2	pKi	=	6.2	Binding	Binding affinity to histamine H1 receptor (unknown origin) by competition binding assayBinding affinity to histamine H1 receptor (unknown origin) by competition binding assay	ChEMBL	254	7	1	1	3.7	C=CCN(CC=C)CCc1c[nH]c2ccc(C)cc12	10.1016/j.bmcl.2015.12.053
		CHEMBL3753318	137414	0	None	-21	19	Human	6.2	pKi	=	6.2	Binding	Binding affinity to histamine H1 receptor (unknown origin) by competition binding assayBinding affinity to histamine H1 receptor (unknown origin) by competition binding assay	ChEMBL	254	7	1	1	3.7	C=CCN(CC=C)CCc1c[nH]c2ccc(C)cc12	10.1016/j.bmcl.2015.12.053
		44304494	202992	0	None	-5495	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	489	12	1	6	4.3	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@@H](C)NC(=O)OC(C)(C)C)CC2)cc1	10.1016/s0960-894x(02)00310-4
		CHEMBL63125	202992	0	None	-5495	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	489	12	1	6	4.3	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@@H](C)NC(=O)OC(C)(C)C)CC2)cc1	10.1016/s0960-894x(02)00310-4
		127049856	140245	0	None	-23	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid scintillation counting method	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3805431	140245	0	None	-23	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid scintillation counting method	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		43229249	140817	1	None	-16	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	279	5	0	2	3.7	O=C(CCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2016.05.053
		CHEMBL3818989	140817	1	None	-16	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	279	5	0	2	3.7	O=C(CCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2016.05.053
		71457264	82621	0	None	-2	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	447	5	1	6	4.4	COc1ccc(S(=O)(=O)n2cc(C)c3cc(Cl)ccc32)cc1NC1CCN(C)CC1	10.1021/jm300955x
		CHEMBL2179217	82621	0	None	-2	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	447	5	1	6	4.4	COc1ccc(S(=O)(=O)n2cc(C)c3cc(Cl)ccc32)cc1NC1CCN(C)CC1	10.1021/jm300955x
		122065	189549	3	None	-1380	8	Guinea pig	6.2	pKi	=	6.2	Binding	Compound is evaluated for binding affinity towards Histamine H1 receptor using [3H]pyrilamine in guinea pig lungCompound is evaluated for binding affinity towards Histamine H1 receptor using [3H]pyrilamine in guinea pig lung	ChEMBL	380	5	1	6	1.5	COc1ccccc1N1CCN(CCn2c(=O)[nH]c3ccccc3c2=O)CC1	10.1021/jm970159v
		CHEMBL51433	189549	3	None	-1380	8	Guinea pig	6.2	pKi	=	6.2	Binding	Compound is evaluated for binding affinity towards Histamine H1 receptor using [3H]pyrilamine in guinea pig lungCompound is evaluated for binding affinity towards Histamine H1 receptor using [3H]pyrilamine in guinea pig lung	ChEMBL	380	5	1	6	1.5	COc1ccccc1N1CCN(CCn2c(=O)[nH]c3ccccc3c2=O)CC1	10.1021/jm970159v
		44591098	176762	0	None	-199	6	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	508	9	0	3	6.6	CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)c1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
		CHEMBL460402	176762	0	None	-199	6	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	508	9	0	3	6.6	CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)c1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
		162651034	180305	0	None	-301	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cell membranes co-expressing RGS4 measured after 60 mins by scintillation counting analysisDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cell membranes co-expressing RGS4 measured after 60 mins by scintillation counting analysis	ChEMBL	435	8	0	5	4.6	O=C(c1ccc(Cl)cc1)c1ccc(OCCCN2CCN(c3ccncc3)CC2)cc1	10.1016/j.ejmech.2020.113041
		CHEMBL4750996	180305	0	None	-301	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cell membranes co-expressing RGS4 measured after 60 mins by scintillation counting analysisDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cell membranes co-expressing RGS4 measured after 60 mins by scintillation counting analysis	ChEMBL	435	8	0	5	4.6	O=C(c1ccc(Cl)cc1)c1ccc(OCCCN2CCN(c3ccncc3)CC2)cc1	10.1016/j.ejmech.2020.113041
		11681378	8269	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	324	5	0	3	4.9	Cc1ccc(C(C)c2c(CCN(C)C)sc3ccccc23)cn1	10.1016/j.bmcl.2010.01.134
		CHEMBL1092496	8269	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	324	5	0	3	4.9	Cc1ccc(C(C)c2c(CCN(C)C)sc3ccccc23)cn1	10.1016/j.bmcl.2010.01.134
		56944383	112119	0	None	-125	12	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]pyrilamine from human recombinant H1 receptor expressed in HEK293 cellsDisplacement of [3H]pyrilamine from human recombinant H1 receptor expressed in HEK293 cells	ChEMBL	487	8	1	6	5.1	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
		CHEMBL3290012	112119	0	None	-125	12	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]pyrilamine from human recombinant H1 receptor expressed in HEK293 cellsDisplacement of [3H]pyrilamine from human recombinant H1 receptor expressed in HEK293 cells	ChEMBL	487	8	1	6	5.1	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
		10104	3566	12	None	-2	6	Human	7.2	pKi	=	7.2	Binding	Compound was evaluated for binding affinity towards cloned human histamine H1 receptors stably expressed in CHO-K1 cells using [3H]mepyramineCompound was evaluated for binding affinity towards cloned human histamine H1 receptors stably expressed in CHO-K1 cells using [3H]mepyramine	ChEMBL	292	5	0	2	4.1	CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C	10.1021/jm020895l
		6604866	3566	12	None	-2	6	Human	7.2	pKi	=	7.2	Binding	Compound was evaluated for binding affinity towards cloned human histamine H1 receptors stably expressed in CHO-K1 cells using [3H]mepyramineCompound was evaluated for binding affinity towards cloned human histamine H1 receptors stably expressed in CHO-K1 cells using [3H]mepyramine	ChEMBL	292	5	0	2	4.1	CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C	10.1021/jm020895l
		CHEMBL1493369	3566	12	None	-2	6	Human	7.2	pKi	=	7.2	Binding	Compound was evaluated for binding affinity towards cloned human histamine H1 receptors stably expressed in CHO-K1 cells using [3H]mepyramineCompound was evaluated for binding affinity towards cloned human histamine H1 receptors stably expressed in CHO-K1 cells using [3H]mepyramine	ChEMBL	292	5	0	2	4.1	CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C	10.1021/jm020895l
		168286548	191389	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	792	20	6	8	2.8	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5192441	191389	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	792	20	6	8	2.8	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		1258	196	12	None	-34673	5	Human	4.2	pKi	=	4.2	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	359	8	1	5	1.5	C[C@H](C(=O)N1CCN(CC1)CCCOc1ccc(cc1)C(=O)C1CC1)N	10.1016/s0960-894x(02)00310-4
		9906860	196	12	None	-34673	5	Human	4.2	pKi	=	4.2	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	359	8	1	5	1.5	C[C@H](C(=O)N1CCN(CC1)CCCOc1ccc(cc1)C(=O)C1CC1)N	10.1016/s0960-894x(02)00310-4
		CHEMBL302196	196	12	None	-34673	5	Human	4.2	pKi	=	4.2	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	359	8	1	5	1.5	C[C@H](C(=O)N1CCN(CC1)CCCOc1ccc(cc1)C(=O)C1CC1)N	10.1016/s0960-894x(02)00310-4
		168286548	191389	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	792	20	6	8	2.8	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5192441	191389	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	792	20	6	8	2.8	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		21527771	70156	1	None	-275	10	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation countingDisplacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation counting	ChEMBL	363	6	1	3	4.2	OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
		CHEMBL1940404	70156	1	None	-275	10	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation countingDisplacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation counting	ChEMBL	363	6	1	3	4.2	OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
		56966475	105462	0	None	-3467	4	Guinea pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenate after 60 mins by liquid scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenate after 60 mins by liquid scintillation counting	ChEMBL	448	8	0	6	4.3	COc1ccccc1N1CCN(CCCCOc2ccc3c4c(c(=O)oc3c2)CCC4)CC1	10.1016/j.ejmech.2014.01.012
		CHEMBL3120682	105462	0	None	-3467	4	Guinea pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenate after 60 mins by liquid scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenate after 60 mins by liquid scintillation counting	ChEMBL	448	8	0	6	4.3	COc1ccccc1N1CCN(CCCCOc2ccc3c4c(c(=O)oc3c2)CCC4)CC1	10.1016/j.ejmech.2014.01.012
		10177985	100656	0	None	-1	4	Rat	8.2	pKi	=	8.2	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	ChEMBL	382	10	1	3	4.9	CN(CCCCc1c[nH]cn1)CCC(c1ccc(Cl)cc1)c1ccccn1	10.1016/s0960-894x(03)00357-3
		CHEMBL292195	100656	0	None	-1	4	Rat	8.2	pKi	=	8.2	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	ChEMBL	382	10	1	3	4.9	CN(CCCCc1c[nH]cn1)CCC(c1ccc(Cl)cc1)c1ccccn1	10.1016/s0960-894x(03)00357-3
		135398745	2914	112	None	1	65	Human	8.2	pKi	=	8.2	Binding	Binding affinity to H1 histamine receptor (unknown origin)Binding affinity to H1 histamine receptor (unknown origin)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmcl.2020.127681
		47	2914	112	None	1	65	Human	8.2	pKi	=	8.2	Binding	Binding affinity to H1 histamine receptor (unknown origin)Binding affinity to H1 histamine receptor (unknown origin)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmcl.2020.127681
		CHEMBL715	2914	112	None	1	65	Human	8.2	pKi	=	8.2	Binding	Binding affinity to H1 histamine receptor (unknown origin)Binding affinity to H1 histamine receptor (unknown origin)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmcl.2020.127681
		DB00334	2914	112	None	1	65	Human	8.2	pKi	=	8.2	Binding	Binding affinity to H1 histamine receptor (unknown origin)Binding affinity to H1 histamine receptor (unknown origin)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmcl.2020.127681
		1210	918	51	None	-20	21	Human	8.2	pKi	=	8.2	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm1013874
		1213	918	51	None	-20	21	Human	8.2	pKi	=	8.2	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm1013874
		2725	918	51	None	-20	21	Human	8.2	pKi	=	8.2	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm1013874
		33036	918	51	None	-20	21	Human	8.2	pKi	=	8.2	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm1013874
		4411	918	51	None	-20	21	Human	8.2	pKi	=	8.2	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm1013874
		616	918	51	None	-20	21	Human	8.2	pKi	=	8.2	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm1013874
		6976	918	51	None	-20	21	Human	8.2	pKi	=	8.2	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm1013874
		716121	918	51	None	-20	21	Human	8.2	pKi	=	8.2	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm1013874
		CHEMBL1201353	918	51	None	-20	21	Human	8.2	pKi	=	8.2	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm1013874
		CHEMBL1554789	918	51	None	-20	21	Human	8.2	pKi	=	8.2	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm1013874
		CHEMBL505	918	51	None	-20	21	Human	8.2	pKi	=	8.2	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm1013874
		DB01114	918	51	None	-20	21	Human	8.2	pKi	=	8.2	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm1013874
		DB13679	918	51	None	-20	21	Human	8.2	pKi	=	8.2	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1021/jm1013874
		10177985	100656	0	None	1	4	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	382	10	1	3	4.9	CN(CCCCc1c[nH]cn1)CCC(c1ccc(Cl)cc1)c1ccccn1	10.1021/jm100064d
		CHEMBL292195	100656	0	None	1	4	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	382	10	1	3	4.9	CN(CCCCc1c[nH]cn1)CCC(c1ccc(Cl)cc1)c1ccccn1	10.1021/jm100064d
		15288693	52858	0	None	4	3	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptorDisplacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptor	ChEMBL	367	5	0	5	3.0	Cn1c(=O)sc2cc(CCN3CCN(Cc4ccccc4)CC3)ccc21	10.1016/s0960-894x(02)00123-3
		CHEMBL15955	52858	0	None	4	3	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptorDisplacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptor	ChEMBL	367	5	0	5	3.0	Cn1c(=O)sc2cc(CCN3CCN(Cc4ccccc4)CC3)ccc21	10.1016/s0960-894x(02)00123-3
		135398745	2914	112	None	1	65	Human	8.2	pKi	=	8.2	Binding	In vitro binding affinity of compound against histamine H1 neuronal receptorIn vitro binding affinity of compound against histamine H1 neuronal receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/S0960-894X(96)00567-7
		47	2914	112	None	1	65	Human	8.2	pKi	=	8.2	Binding	In vitro binding affinity of compound against histamine H1 neuronal receptorIn vitro binding affinity of compound against histamine H1 neuronal receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/S0960-894X(96)00567-7
		CHEMBL715	2914	112	None	1	65	Human	8.2	pKi	=	8.2	Binding	In vitro binding affinity of compound against histamine H1 neuronal receptorIn vitro binding affinity of compound against histamine H1 neuronal receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/S0960-894X(96)00567-7
		DB00334	2914	112	None	1	65	Human	8.2	pKi	=	8.2	Binding	In vitro binding affinity of compound against histamine H1 neuronal receptorIn vitro binding affinity of compound against histamine H1 neuronal receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/S0960-894X(96)00567-7
		10177985	100656	0	None	1	4	Human	8.2	pKi	=	8.2	Binding	Inhibition constant against histamine H1 receptorInhibition constant against histamine H1 receptor	ChEMBL	382	10	1	3	4.9	CN(CCCCc1c[nH]cn1)CCC(c1ccc(Cl)cc1)c1ccccn1	10.1021/jm058225d
		CHEMBL292195	100656	0	None	1	4	Human	8.2	pKi	=	8.2	Binding	Inhibition constant against histamine H1 receptorInhibition constant against histamine H1 receptor	ChEMBL	382	10	1	3	4.9	CN(CCCCc1c[nH]cn1)CCC(c1ccc(Cl)cc1)c1ccccn1	10.1021/jm058225d
		57402472	67879	0	None	-1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	526	11	1	6	4.0	COc1ccc(CN(CCN(C)CCN2CCN(C(=O)c3cc4ccccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		CHEMBL1910381	67879	0	None	-1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	526	11	1	6	4.0	COc1ccc(CN(CCN(C)CCN2CCN(C(=O)c3cc4ccccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		45271166	196416	1	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	401	5	0	6	4.4	COc1ccc(Cn2c(N3CCC(n4cc(C)cn4)CC3)nc3ccccc32)cc1	10.1016/j.bmcl.2009.05.086
		CHEMBL562894	196416	1	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	401	5	0	6	4.4	COc1ccc(Cn2c(N3CCC(n4cc(C)cn4)CC3)nc3ccccc32)cc1	10.1016/j.bmcl.2009.05.086
		9819674	12934	0	None	1	5	Rat	8.2	pKi	=	8.2	Binding	Half-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenateHalf-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenate	ChEMBL	347	3	1	5	2.4	OCCN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		CHEMBL118919	12934	0	None	1	5	Rat	8.2	pKi	=	8.2	Binding	Half-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenateHalf-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenate	ChEMBL	347	3	1	5	2.4	OCCN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		53320177	57747	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	293	6	0	3	3.4	CCN(C)CCC1=C(Cc2cnccn2)c2ccccc2C1	10.1016/j.bmcl.2010.12.053
		CHEMBL1669405	57747	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	293	6	0	3	3.4	CCN(C)CCC1=C(Cc2cnccn2)c2ccccc2C1	10.1016/j.bmcl.2010.12.053
		10969390	59677	0	None	4	6	Human	8.1	pKi	=	8.1	Binding	Compound was evaluated for binding affinity towards cloned human histamine H1 receptors stably expressed in CHO-K1 cells using [3H]mepyramineCompound was evaluated for binding affinity towards cloned human histamine H1 receptors stably expressed in CHO-K1 cells using [3H]mepyramine	ChEMBL	324	7	0	2	4.5	CC(C1=C(CCN(C)CCF)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL172233	59677	0	None	4	6	Human	8.1	pKi	=	8.1	Binding	Compound was evaluated for binding affinity towards cloned human histamine H1 receptors stably expressed in CHO-K1 cells using [3H]mepyramineCompound was evaluated for binding affinity towards cloned human histamine H1 receptors stably expressed in CHO-K1 cells using [3H]mepyramine	ChEMBL	324	7	0	2	4.5	CC(C1=C(CCN(C)CCF)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		44401041	70487	0	None	-1	7	Human	8.1	pKi	=	8.1	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	313	2	0	3	4.1	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL194659	70487	0	None	-1	7	Human	8.1	pKi	=	8.1	Binding	Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor	ChEMBL	313	2	0	3	4.1	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		10070478	13466	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	415	2	0	3	5.6	Cc1ccc(CN2CCC(=C3c4ccc(Cl)cc4CCc4cccnc43)CC2)cn1	10.1021/acs.jmedchem.9b00447
		CHEMBL1193187	13466	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	415	2	0	3	5.6	Cc1ccc(CN2CCC(=C3c4ccc(Cl)cc4CCc4cccnc43)CC2)cn1	10.1021/acs.jmedchem.9b00447
		44389301	64311	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity for human Histamine H1 receptor in CHO K1 cellsBinding affinity for human Histamine H1 receptor in CHO K1 cells	ChEMBL	619	13	1	6	6.8	CC(C)COC(=O)N(O)CCC#Cc1ccc(OCCCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1016/j.bmcl.2004.12.023
		CHEMBL181085	64311	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity for human Histamine H1 receptor in CHO K1 cellsBinding affinity for human Histamine H1 receptor in CHO K1 cells	ChEMBL	619	13	1	6	6.8	CC(C)COC(=O)N(O)CCC#Cc1ccc(OCCCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1016/j.bmcl.2004.12.023
		44305842	203399	0	None	-	1	Guinea pig	8.1	pKi	=	8.1	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	381	4	1	4	4.1	O=C(O)c1ccc2c(c1)/C(=C\CCN1CCSCC1)c1ccccc1CO2	10.1021/jm00089a020
		CHEMBL65492	203399	0	None	-	1	Guinea pig	8.1	pKi	=	8.1	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	ChEMBL	381	4	1	4	4.1	O=C(O)c1ccc2c(c1)/C(=C\CCN1CCSCC1)c1ccccc1CO2	10.1021/jm00089a020
		46884640	7913	0	None	2187	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	279	5	0	3	3.0	CN(C)CCC1=C(Cc2cccnn2)c2ccccc2C1	10.1016/j.bmcl.2010.02.055
		CHEMBL1090197	7913	0	None	2187	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	279	5	0	3	3.0	CN(C)CCC1=C(Cc2cccnn2)c2ccccc2C1	10.1016/j.bmcl.2010.02.055
		11846300	80266	3	None	2	4	Human	8.1	pKi	=	8.1	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1021/jm800876b
		CHEMBL213912	80266	3	None	2	4	Human	8.1	pKi	=	8.1	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1021/jm800876b
		11846300	80266	3	None	2	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]mepyramine from human histamine H1 receptorDisplacement of [3H]mepyramine from human histamine H1 receptor	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1021/jm051008s
		CHEMBL213912	80266	3	None	2	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]mepyramine from human histamine H1 receptorDisplacement of [3H]mepyramine from human histamine H1 receptor	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1021/jm051008s
		59295931	84212	0	None	-5	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	462	7	3	5	3.5	O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1n[nH]c2ccccc12	10.1016/j.bmcl.2012.09.113
		CHEMBL2208429	84212	0	None	-5	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	462	7	3	5	3.5	O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1n[nH]c2ccccc12	10.1016/j.bmcl.2012.09.113
		59295935	84010	0	None	-3	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	507	7	3	5	3.6	O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(F)ccc12	10.1016/j.bmcl.2012.09.112
		CHEMBL2207278	84010	0	None	-3	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	507	7	3	5	3.6	O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(F)ccc12	10.1016/j.bmcl.2012.09.112
		10408773	165299	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	401	2	0	3	5.3	Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(Cc2ccncc2)CC1	10.1021/acs.jmedchem.9b00447
		CHEMBL423316	165299	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	401	2	0	3	5.3	Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(Cc2ccncc2)CC1	10.1021/acs.jmedchem.9b00447
		155527187	171152	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	414	2	0	2	6.2	Cc1cccc(CN2CCC(=C3c4ccc(Cl)cc4CCc4cccnc43)CC2)c1	10.1021/acs.jmedchem.9b00447
		CHEMBL4458676	171152	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	414	2	0	2	6.2	Cc1cccc(CN2CCC(=C3c4ccc(Cl)cc4CCc4cccnc43)CC2)c1	10.1021/acs.jmedchem.9b00447
		134156988	154519	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	281	7	0	2	3.8	c1ccc(Cc2ccccc2OCCCN2CCC2)cc1	10.1021/acs.jmedchem.6b00981
		CHEMBL3984221	154519	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	281	7	0	2	3.8	c1ccc(Cc2ccccc2OCCCN2CCC2)cc1	10.1021/acs.jmedchem.6b00981
		CHEMBL3990754	154519	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysisDisplacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by microbeta liquid scintillation counting analysis	ChEMBL	281	7	0	2	3.8	c1ccc(Cc2ccccc2OCCCN2CCC2)cc1	10.1021/acs.jmedchem.6b00981
		135398737	958	93	None	-2	89	Guinea pig	8.1	pKi	=	8.1	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm070516u
		38	958	93	None	-2	89	Guinea pig	8.1	pKi	=	8.1	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm070516u
		722	958	93	None	-2	89	Guinea pig	8.1	pKi	=	8.1	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm070516u
		CHEMBL42	958	93	None	-2	89	Guinea pig	8.1	pKi	=	8.1	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm070516u
		DB00363	958	93	None	-2	89	Guinea pig	8.1	pKi	=	8.1	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm070516u
		2389	3331	118	None	-52	67	Guinea pig	8.1	pKi	=	8.1	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm070516u
		5073	3331	118	None	-52	67	Guinea pig	8.1	pKi	=	8.1	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm070516u
		96	3331	118	None	-52	67	Guinea pig	8.1	pKi	=	8.1	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm070516u
		CHEMBL85	3331	118	None	-52	67	Guinea pig	8.1	pKi	=	8.1	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm070516u
		DB00734	3331	118	None	-52	67	Guinea pig	8.1	pKi	=	8.1	Binding	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumDisplacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm070516u
		22397436	82237	0	None	6	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	510	5	0	5	4.5	CS(=O)(=O)c1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1	10.1016/j.bmcl.2012.08.124
		CHEMBL2171019	82237	0	None	6	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	510	5	0	5	4.5	CS(=O)(=O)c1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1	10.1016/j.bmcl.2012.08.124
		17963183	82262	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	545	5	1	5	5.1	O=C(NS(=O)(=O)c1cccc(Cl)c1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.124
		CHEMBL2171043	82262	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	545	5	1	5	5.1	O=C(NS(=O)(=O)c1cccc(Cl)c1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.124
		44267108	98345	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.	ChEMBL	366	0	0	2	4.6	CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cc(C)cnc32)CC1	10.1016/S0960-894X(00)80290-5
		CHEMBL275109	98345	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.	ChEMBL	366	0	0	2	4.6	CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cc(C)cnc32)CC1	10.1016/S0960-894X(00)80290-5
		120445	202064	4	None	16	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cellsDisplacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cells	ChEMBL	253	6	0	1	4.2	CN(C)CCCC(c1ccccc1)c1ccccc1	10.1016/j.bmc.2009.08.016
		CHEMBL608689	202064	4	None	16	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cellsDisplacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cells	ChEMBL	253	6	0	1	4.2	CN(C)CCCC(c1ccccc1)c1ccccc1	10.1016/j.bmc.2009.08.016
		9998826	120477	0	None	-69	5	Rat	7.2	pKi	=	7.2	Binding	Inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat cortexInhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat cortex	ChEMBL	363	5	1	3	3.1	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccccc1	10.1021/jm950759z
		CHEMBL354210	120477	0	None	-69	5	Rat	7.2	pKi	=	7.2	Binding	Inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat cortexInhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat cortex	ChEMBL	363	5	1	3	3.1	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccccc1	10.1021/jm950759z
		44266960	97156	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.	ChEMBL	380	1	0	3	4.1	CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cc(C=O)cnc32)CC1	10.1016/S0960-894X(00)80290-5
		CHEMBL268022	97156	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.	ChEMBL	380	1	0	3	4.1	CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cc(C=O)cnc32)CC1	10.1016/S0960-894X(00)80290-5
		69082816	74937	0	None	-4168	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity to H1 receptorBinding affinity to H1 receptor	ChEMBL	431	5	0	3	4.1	C[C@H]1CCCN1C(=O)c1ccc(-c2ccc3c(c2)CCN(CCN2CCCC2)C3=O)cc1	10.1021/jm300011d
		CHEMBL2031877	74937	0	None	-4168	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity to H1 receptorBinding affinity to H1 receptor	ChEMBL	431	5	0	3	4.1	C[C@H]1CCCN1C(=O)c1ccc(-c2ccc3c(c2)CCN(CCN2CCCC2)C3=O)cc1	10.1021/jm300011d
		145986752	167276	0	None	-16	17	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]Pyrilamine from human H1 receptor expressed in HEK cells by radioligand binding assay	ChEMBL	562	10	1	5	7.3	COc1ccc(N(CCCCN2CCC(O)(c3ccc(Cl)c(C(F)(F)F)c3)CC2)c2ccc(OC)cc2)cc1	10.1016/j.bmcl.2018.10.036
		CHEMBL4293307	167276	0	None	-16	17	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]Pyrilamine from human H1 receptor expressed in HEK cells by radioligand binding assay	ChEMBL	562	10	1	5	7.3	COc1ccc(N(CCCCN2CCC(O)(c3ccc(Cl)c(C(F)(F)F)c3)CC2)c2ccc(OC)cc2)cc1	10.1016/j.bmcl.2018.10.036
		56963799	74895	0	None	-17782	10	Human	5.2	pKi	=	5.2	Binding	Binding affinity to human recombinant H1 receptorBinding affinity to human recombinant H1 receptor	ChEMBL	378	6	0	5	4.6	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc([N+](=O)[O-])cc3)ccc2o1	10.1021/jm201690h
		CHEMBL2031737	74895	0	None	-17782	10	Human	5.2	pKi	=	5.2	Binding	Binding affinity to human recombinant H1 receptorBinding affinity to human recombinant H1 receptor	ChEMBL	378	6	0	5	4.6	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc([N+](=O)[O-])cc3)ccc2o1	10.1021/jm201690h
		141485893	175738	0	None	-	1	Guinea pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysisDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysis	ChEMBL	317	5	0	4	1.3	CN1CCN(CCCOc2ccc3c(c2)C(=O)N(C)CC3)CC1	10.1016/j.bmcl.2019.04.015
		CHEMBL4583068	175738	0	None	-	1	Guinea pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysisDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysis	ChEMBL	317	5	0	4	1.3	CN1CCN(CCCOc2ccc3c(c2)C(=O)N(C)CC3)CC1	10.1016/j.bmcl.2019.04.015
		45833388	69024	7	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	274	4	0	7	1.3	CN(C)CCSc1nc2ccccc2c2nnnn12	10.1021/jm2011589
		CHEMBL1923525	69024	7	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	274	4	0	7	1.3	CN(C)CCSc1nc2ccccc2c2nnnn12	10.1021/jm2011589
		2537688	69025	3	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	264	3	1	6	0.8	OCCN1CCN(c2ncnc3sccc23)CC1	10.1021/jm2011589
		CHEMBL1923526	69025	3	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	264	3	1	6	0.8	OCCN1CCN(c2ncnc3sccc23)CC1	10.1021/jm2011589
		168294776	193026	0	None	-11	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	366	7	3	4	2.6	Cc1nnc(CCCN/C(N)=N/C(=O)NCC(C)C2CCCCC2)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5209479	193026	0	None	-11	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	366	7	3	4	2.6	Cc1nnc(CCCN/C(N)=N/C(=O)NCC(C)C2CCCCC2)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222831	193026	0	None	-11	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	366	7	3	4	2.6	Cc1nnc(CCCN/C(N)=N/C(=O)NCC(C)C2CCCCC2)s1	10.1021/acs.jmedchem.1c00692
		164609017	184425	0	None	-125	6	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	416	10	4	4	3.2	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)CCCc1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4846201	184425	0	None	-125	6	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	416	10	4	4	3.2	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)CCCc1ccccc1	10.1016/j.ejmech.2021.113190
		44304211	102197	0	None	-6918	3	Human	4.2	pKi	=	4.2	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	373	9	1	5	1.9	CC[C@@H](N)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		CHEMBL302829	102197	0	None	-6918	3	Human	4.2	pKi	=	4.2	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	373	9	1	5	1.9	CC[C@@H](N)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		129103313	166753	0	None	-70	6	Guinea pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by liquid scintillation countingDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by liquid scintillation counting	ChEMBL	447	6	0	4	5.0	O=C1CCc2cc(CCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc3c2N1CC3	10.1021/acs.jmedchem.8b01096
		CHEMBL4283548	166753	0	None	-70	6	Guinea pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by liquid scintillation countingDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by liquid scintillation counting	ChEMBL	447	6	0	4	5.0	O=C1CCc2cc(CCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc3c2N1CC3	10.1021/acs.jmedchem.8b01096
		145980875	166707	0	None	-5	11	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]Pyrilamine from human H1 receptor expressed in HEK cells by radioligand binding assay	ChEMBL	443	7	1	2	6.2	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCCc2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		CHEMBL4282702	166707	0	None	-5	11	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]Pyrilamine from human H1 receptor expressed in HEK cells by radioligand binding assay	ChEMBL	443	7	1	2	6.2	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCCc2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		145992489	166977	0	None	-2	12	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]Pyrilamine from human H1 receptor expressed in HEK cells by radioligand binding assay	ChEMBL	535	7	1	2	7.8	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC=C(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		CHEMBL4287623	166977	0	None	-2	12	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]Pyrilamine from human H1 receptor expressed in HEK cells by radioligand binding assay	ChEMBL	535	7	1	2	7.8	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC=C(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		95104704	162138	1	None	2	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	344	6	1	4	3.1	CCOc1ccc([C@H](O)CN2CCN(c3ccccc3F)CC2)cc1	10.1021/acs.jmedchem.8b00718
		CHEMBL4161676	162138	1	None	2	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting method	ChEMBL	344	6	1	4	3.1	CCOc1ccc([C@H](O)CN2CCN(c3ccccc3F)CC2)cc1	10.1021/acs.jmedchem.8b00718
		14885628	119434	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	336	0	0	2	3.8	CC(=O)N1CCC(=C2c3ccc(F)cc3CCc3cccnc32)CC1	10.1021/jm00105a069
		CHEMBL344942	119434	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	336	0	0	2	3.8	CC(=O)N1CCC(=C2c3ccc(F)cc3CCc3cccnc32)CC1	10.1021/jm00105a069
		25216680	74944	0	None	-7244	3	Human	5.1	pKi	=	5.1	Binding	Binding affinity to H1 receptorBinding affinity to H1 receptor	ChEMBL	405	6	1	3	3.6	CCNC(=O)c1ccc(-c2ccc3c(c2)CCN(CCN2CCC[C@H]2C)C3=O)cc1	10.1021/jm300011d
		CHEMBL2031884	74944	0	None	-7244	3	Human	5.1	pKi	=	5.1	Binding	Binding affinity to H1 receptorBinding affinity to H1 receptor	ChEMBL	405	6	1	3	3.6	CCNC(=O)c1ccc(-c2ccc3c(c2)CCN(CCN2CCC[C@H]2C)C3=O)cc1	10.1021/jm300011d
		44304378	163272	0	None	-35	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	423	11	0	5	4.1	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3cccnc3)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL418658	163272	0	None	-35	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	423	11	0	5	4.1	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3cccnc3)CC2)cc1	10.1016/s0960-894x(02)00309-8
		56852956	112043	1	None	-186	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor by PDSP assayDisplacement of [3H]pyrilamine from human histamine H1 receptor by PDSP assay	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.bmc.2014.04.026
		CHEMBL3289656	112043	1	None	-186	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor by PDSP assayDisplacement of [3H]pyrilamine from human histamine H1 receptor by PDSP assay	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.bmc.2014.04.026
		168277996	192846	0	None	-60	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	380	4	4	4	3.3	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCc2ccccc2)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5173373	192846	0	None	-60	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	380	4	4	4	3.3	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCc2ccccc2)c1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221736	192846	0	None	-60	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	380	4	4	4	3.3	Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCc2ccccc2)c1	10.1021/acs.jmedchem.1c00692
		46216771	202165	0	None	-3	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]Pyrilamine from human cloned histamine H1 receptorDisplacement of [3H]Pyrilamine from human cloned histamine H1 receptor	ChEMBL	327	6	1	1	4.9	c1ccc(CCCNCC2c3ccccc3Cc3ccccc32)cc1	10.1016/j.bmcl.2009.12.064
		CHEMBL609328	202165	0	None	-3	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]Pyrilamine from human cloned histamine H1 receptorDisplacement of [3H]Pyrilamine from human cloned histamine H1 receptor	ChEMBL	327	6	1	1	4.9	c1ccc(CCCNCC2c3ccccc3Cc3ccccc32)cc1	10.1016/j.bmcl.2009.12.064
		1353	1911	93	None	-489	83	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm030480f
		3559	1911	93	None	-489	83	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm030480f
		86	1911	93	None	-489	83	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm030480f
		CHEMBL54	1911	93	None	-489	83	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm030480f
		DB00502	1911	93	None	-489	83	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards human histamine H1 receptorBinding affinity towards human histamine H1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm030480f
		56852956	112043	1	None	-186	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor by PDSP assayDisplacement of [3H]pyrilamine from human histamine H1 receptor by PDSP assay	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.bmc.2014.04.026
		CHEMBL3289656	112043	1	None	-186	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor by PDSP assayDisplacement of [3H]pyrilamine from human histamine H1 receptor by PDSP assay	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.bmc.2014.04.026
		49841719	69737	0	None	-1513	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human H1 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H1 receptor expressed in HEK cell membranes	ChEMBL	309	2	1	6	2.2	CN1CCN(c2nc(N)nc3cc(-c4ccoc4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
		CHEMBL1935571	69737	0	None	-1513	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]histamine from human H1 receptor expressed in HEK cell membranesDisplacement of [3H]histamine from human H1 receptor expressed in HEK cell membranes	ChEMBL	309	2	1	6	2.2	CN1CCN(c2nc(N)nc3cc(-c4ccoc4)ccc23)CC1	10.1016/j.bmcl.2011.10.104
		127051015	140874	0	None	-27	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3818128	140874	0	None	-27	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3819731	140874	0	None	-27	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		16655023	107441	2	None	-60	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]pyrilamine from human cloned histamine H1 receptorDisplacement of [3H]pyrilamine from human cloned histamine H1 receptor	ChEMBL	481	7	0	7	3.7	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2	10.1016/j.bmc.2007.03.053
		CHEMBL318235	107441	2	None	-60	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]pyrilamine from human cloned histamine H1 receptorDisplacement of [3H]pyrilamine from human cloned histamine H1 receptor	ChEMBL	481	7	0	7	3.7	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2	10.1016/j.bmc.2007.03.053
		44304287	202898	0	None	-4	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	428	11	0	5	4.7	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3cccs3)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL62726	202898	0	None	-4	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	428	11	0	5	4.7	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3cccs3)CC2)cc1	10.1016/s0960-894x(02)00309-8
		132356	14677	1	None	-	1	Guinea pig	6.1	pKi	=	6.1	Binding	Inhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptorInhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptor	ChEMBL	473	7	1	4	6.1	O=C(O)c1ccc2c(c1)C(SCCN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2	10.1021/jm00055a013
		CHEMBL1205688	14677	1	None	-	1	Guinea pig	6.1	pKi	=	6.1	Binding	Inhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptorInhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptor	ChEMBL	473	7	1	4	6.1	O=C(O)c1ccc2c(c1)C(SCCN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2	10.1021/jm00055a013
		CHEMBL133778	14677	1	None	-	1	Guinea pig	6.1	pKi	=	6.1	Binding	Inhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptorInhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptor	ChEMBL	473	7	1	4	6.1	O=C(O)c1ccc2c(c1)C(SCCN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2	10.1021/jm00055a013
		44333988	4535	0	None	-199	3	Human	5.1	pKi	=	5.1	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	367	8	1	5	2.6	CC(=O)c1ccc(OCCCN2CC[C@H](NC(=O)c3cccnc3)C2)cc1	10.1016/s0960-894x(02)00685-6
		CHEMBL102331	4535	0	None	-199	3	Human	5.1	pKi	=	5.1	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	367	8	1	5	2.6	CC(=O)c1ccc(OCCCN2CC[C@H](NC(=O)c3cccnc3)C2)cc1	10.1016/s0960-894x(02)00685-6
		44304037	102693	0	None	-204	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	362	9	0	5	3.2	CCCC(=O)c1ccc(OCCCN2CCN(C(=O)OCC)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL304714	102693	0	None	-204	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	362	9	0	5	3.2	CCCC(=O)c1ccc(OCCCN2CCN(C(=O)OCC)CC2)cc1	10.1016/s0960-894x(02)00309-8
		127051015	140874	0	None	-27	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3818128	140874	0	None	-27	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3819731	140874	0	None	-27	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
		24759623	96349	20	None	-18	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in NIH3T3 cellsDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in NIH3T3 cells	ChEMBL	318	3	0	4	3.0	CN1CCN(c2nc3ccccc3nc2Cc2ccccc2)CC1	10.1021/jm7014217
		CHEMBL261551	96349	20	None	-18	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in NIH3T3 cellsDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in NIH3T3 cells	ChEMBL	318	3	0	4	3.0	CN1CCN(c2nc3ccccc3nc2Cc2ccccc2)CC1	10.1021/jm7014217
		168294449	193018	0	None	-74	6	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	367	7	4	5	1.9	CC(CNC(=O)/N=C(\N)NCCCc1nnc(N)s1)C1CCCCC1	10.1021/acs.jmedchem.1c00692
		CHEMBL5204599	193018	0	None	-74	6	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	367	7	4	5	1.9	CC(CNC(=O)/N=C(\N)NCCCc1nnc(N)s1)C1CCCCC1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222793	193018	0	None	-74	6	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	367	7	4	5	1.9	CC(CNC(=O)/N=C(\N)NCCCc1nnc(N)s1)C1CCCCC1	10.1021/acs.jmedchem.1c00692
		162646011	179735	0	None	-109	2	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cell membranes co-expressing RGS4 measured after 60 mins by scintillation counting analysisDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cell membranes co-expressing RGS4 measured after 60 mins by scintillation counting analysis	ChEMBL	347	6	0	4	3.8	c1ccc2cc(OCCCN3CCN(c4ccncc4)CC3)ccc2c1	10.1016/j.ejmech.2020.113041
		CHEMBL4744110	179735	0	None	-109	2	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cell membranes co-expressing RGS4 measured after 60 mins by scintillation counting analysisDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cell membranes co-expressing RGS4 measured after 60 mins by scintillation counting analysis	ChEMBL	347	6	0	4	3.8	c1ccc2cc(OCCCN3CCN(c4ccncc4)CC3)ccc2c1	10.1016/j.ejmech.2020.113041
		151221	202395	11	None	21	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cellsDisplacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cells	ChEMBL	239	5	0	1	3.8	CN(C)CCC(c1ccccc1)c1ccccc1	10.1016/j.bmc.2009.08.016
		CHEMBL610739	202395	11	None	21	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cellsDisplacement of [3H]chlorphniramine from human histamine H1 receptor expressed in cells	ChEMBL	239	5	0	1	3.8	CN(C)CCC(c1ccccc1)c1ccccc1	10.1016/j.bmc.2009.08.016
		11659397	195282	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation counting	ChEMBL	297	5	0	4	3.4	CN(C)CCc1sc2ccccc2c1Cc1cnccn1	10.1021/jm900933k
		CHEMBL551340	195282	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation counting	ChEMBL	297	5	0	4	3.4	CN(C)CCc1sc2ccccc2c1Cc1cnccn1	10.1021/jm900933k
		45267774	196207	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	416	5	0	6	4.1	CN(c1ncccn1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1	10.1016/j.bmcl.2009.05.086
		CHEMBL561489	196207	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay	ChEMBL	416	5	0	6	4.1	CN(c1ncccn1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1	10.1016/j.bmcl.2009.05.086
		44334556	107267	0	None	-128	3	Human	4.1	pKi	=	4.1	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	449	10	3	7	1.7	CC(=O)c1ccc(OCCCN2CC[C@H](NC(=O)[C@H](CO)NC(=O)OC(C)(C)C)C2)cc1	10.1016/s0960-894x(02)00685-6
		CHEMBL316968	107267	0	None	-128	3	Human	4.1	pKi	=	4.1	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	449	10	3	7	1.7	CC(=O)c1ccc(OCCCN2CC[C@H](NC(=O)[C@H](CO)NC(=O)OC(C)(C)C)C2)cc1	10.1016/s0960-894x(02)00685-6
		44335172	5097	0	None	-3	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	374	7	0	5	4.0	CCOC(=O)N1CCN(CCCOc2ccc(-c3ccsc3)cc2)CC1	10.1016/s0960-894x(02)00648-0
		CHEMBL105567	5097	0	None	-3	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	374	7	0	5	4.0	CCOC(=O)N1CCN(CCCOc2ccc(-c3ccsc3)cc2)CC1	10.1016/s0960-894x(02)00648-0
		168286141	192924	0	None	-3	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	450	8	4	4	4.8	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5192993	192924	0	None	-3	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	450	8	4	4	4.8	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)cc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222231	192924	0	None	-3	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	450	8	4	4	4.8	Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)cc1	10.1021/acs.jmedchem.1c00692
		29298	203450	1	None	-794	4	Human	5.1	pKi	=	5.1	Binding	Compound was tested for its binding affinity towards human H1 receptorCompound was tested for its binding affinity towards human H1 receptor	ChEMBL	297	5	1	3	3.9	CN(C)CCCNc1c2c(nc3ccccc13)CCCCC2	10.1016/s0960-894x(03)00356-1
		CHEMBL65849	203450	1	None	-794	4	Human	5.1	pKi	=	5.1	Binding	Compound was tested for its binding affinity towards human H1 receptorCompound was tested for its binding affinity towards human H1 receptor	ChEMBL	297	5	1	3	3.9	CN(C)CCCNc1c2c(nc3ccccc13)CCCCC2	10.1016/s0960-894x(03)00356-1
		57390224	67877	0	None	-38	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	503	8	1	5	4.7	COc1ccc(CN(CCN2CCN(C(=O)c3cc4cc(Cl)ccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		CHEMBL1910379	67877	0	None	-38	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingDisplacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting	ChEMBL	503	8	1	5	4.7	COc1ccc(CN(CCN2CCN(C(=O)c3cc4cc(Cl)ccc4[nH]3)CC2)c2ccccn2)cc1	10.1016/j.bmcl.2011.09.001
		44335483	5293	0	None	-257	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	336	6	1	4	3.5	N#Cc1ccc(-c2ccc(OCCCN3CCCC(O)C3)cc2)cc1	10.1016/s0960-894x(02)00648-0
		CHEMBL106596	5293	0	None	-257	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	336	6	1	4	3.5	N#Cc1ccc(-c2ccc(OCCCN3CCCC(O)C3)cc2)cc1	10.1016/s0960-894x(02)00648-0
		164614549	184943	0	None	-549	6	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	340	9	4	4	2.2	CCCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1016/j.ejmech.2021.113190
		CHEMBL4853668	184943	0	None	-549	6	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	340	9	4	4	2.2	CCCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1016/j.ejmech.2021.113190
		164626153	186378	0	None	-3801	6	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	378	6	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1cccc(F)c1	10.1016/j.ejmech.2021.113190
		CHEMBL4875600	186378	0	None	-3801	6	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	378	6	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1cccc(F)c1	10.1016/j.ejmech.2021.113190
		164611807	184984	0	None	-229	4	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	376	6	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=S)N[C@@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4854278	184984	0	None	-229	4	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	376	6	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=S)N[C@@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		1353	1911	93	None	-489	83	Human	6.1	pKi	=	6.1	Binding	Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		3559	1911	93	None	-489	83	Human	6.1	pKi	=	6.1	Binding	Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		86	1911	93	None	-489	83	Human	6.1	pKi	=	6.1	Binding	Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		CHEMBL54	1911	93	None	-489	83	Human	6.1	pKi	=	6.1	Binding	Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		DB00502	1911	93	None	-489	83	Human	6.1	pKi	=	6.1	Binding	Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		44207909	16699	3	None	-2	9	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human histamine H1 receptor by radioligand displacement assayBinding affinity to human histamine H1 receptor by radioligand displacement assay	ChEMBL	407	7	1	4	2.6	O=C(Cc1ccccc1)NC1CCN(CCCN2C(=O)COc3ccccc32)CC1	10.1021/jm100697g
		CHEMBL1242923	16699	3	None	-2	9	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human histamine H1 receptor by radioligand displacement assayBinding affinity to human histamine H1 receptor by radioligand displacement assay	ChEMBL	407	7	1	4	2.6	O=C(Cc1ccccc1)NC1CCN(CCCN2C(=O)COc3ccccc32)CC1	10.1021/jm100697g
		10403711	96333	33	None	-4168	9	Human	5.1	pKi	=	5.1	Binding	Inhibition of histamine H1 receptor (unknown origin)Inhibition of histamine H1 receptor (unknown origin)	ChEMBL	320	3	4	9	-1.7	Nc1ncnc2c1ncn2[C@@H]1O[C@H](C(=O)NC2CC2)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.8b01662
		CHEMBL261482	96333	33	None	-4168	9	Human	5.1	pKi	=	5.1	Binding	Inhibition of histamine H1 receptor (unknown origin)Inhibition of histamine H1 receptor (unknown origin)	ChEMBL	320	3	4	9	-1.7	Nc1ncnc2c1ncn2[C@@H]1O[C@H](C(=O)NC2CC2)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.8b01662
		44591099	176190	0	None	-295	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	494	10	0	3	7.0	CN(CCC=C1c2ccccc2CCc2ccccc21)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
		CHEMBL459350	176190	0	None	-295	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	ChEMBL	494	10	0	3	7.0	CN(CCC=C1c2ccccc2CCc2ccccc21)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
		44304259	100615	0	None	-2	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	462	11	0	5	5.4	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3sccc3Cl)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL291882	100615	0	None	-2	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	462	11	0	5	5.4	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3sccc3Cl)CC2)cc1	10.1016/s0960-894x(02)00309-8
		71072113	81262	0	None	-3	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	504	8	1	4	5.6	Cc1ccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158774	81262	0	None	-3	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	504	8	1	4	5.6	Cc1ccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1	10.1016/j.bmcl.2012.08.103
		66615678	81268	0	None	-19	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	488	8	1	4	5.0	Cc1cc(Cl)ccc1OC1CCN(CC2CCN([C@@H](Cc3ccc(F)cc3)C(=O)O)CC2)CC1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158780	81268	0	None	-19	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	488	8	1	4	5.0	Cc1cc(Cl)ccc1OC1CCN(CC2CCN([C@@H](Cc3ccc(F)cc3)C(=O)O)CC2)CC1	10.1016/j.bmcl.2012.08.103
		66615702	81275	0	None	-100	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	522	8	1	4	5.8	C[C@](Cc1ccc(F)cc1)(C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158787	81275	0	None	-100	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	522	8	1	4	5.8	C[C@](Cc1ccc(F)cc1)(C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmcl.2012.08.103
		71456722	81281	0	None	-39	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	486	8	1	4	4.9	Cc1cc(F)ccc1OC1CCN(CC2CCN([C@@](C)(Cc3ccc(F)cc3)C(=O)O)CC2)CC1	10.1016/j.bmcl.2012.08.103
		CHEMBL2158793	81281	0	None	-39	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	486	8	1	4	4.9	Cc1cc(F)ccc1OC1CCN(CC2CCN([C@@](C)(Cc3ccc(F)cc3)C(=O)O)CC2)CC1	10.1016/j.bmcl.2012.08.103
		127026052	137553	0	None	-4	19	Human	7.1	pKi	=	7.1	Binding	Binding affinity to histamine H1 receptor (unknown origin) by competition binding assayBinding affinity to histamine H1 receptor (unknown origin) by competition binding assay	ChEMBL	258	7	1	1	3.5	C=CCN(CC=C)CCc1c[nH]c2ccc(F)cc12	10.1016/j.bmcl.2015.12.053
		CHEMBL3754496	137553	0	None	-4	19	Human	7.1	pKi	=	7.1	Binding	Binding affinity to histamine H1 receptor (unknown origin) by competition binding assayBinding affinity to histamine H1 receptor (unknown origin) by competition binding assay	ChEMBL	258	7	1	1	3.5	C=CCN(CC=C)CCc1c[nH]c2ccc(F)cc12	10.1016/j.bmcl.2015.12.053
		59296073	84205	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	483	8	2	6	3.0	N#Cc1cccc(S(=O)(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1	10.1016/j.bmcl.2012.09.113
		CHEMBL2208422	84205	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in recombinant CHOK1 cells after 1 hr	ChEMBL	483	8	2	6	3.0	N#Cc1cccc(S(=O)(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1	10.1016/j.bmcl.2012.09.113
		59296077	84008	0	None	-5	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	547	8	3	7	2.5	Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3cc(S(C)(=O)=O)ccc23)CC1	10.1016/j.bmcl.2012.09.112
		CHEMBL2207276	84008	0	None	-5	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hrDisplacement of [3H]-pyrilamine from human recombinant H1 histamine receptor expressed in CHOK1 cells after 1 hr	ChEMBL	547	8	3	7	2.5	Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3cc(S(C)(=O)=O)ccc23)CC1	10.1016/j.bmcl.2012.09.112
		1222	881	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor N7.45C mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor N7.45C mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/nchembio714
		2678	881	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor N7.45C mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor N7.45C mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/nchembio714
		581	881	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor N7.45C mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor N7.45C mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/nchembio714
		CHEMBL1000	881	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor N7.45C mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor N7.45C mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/nchembio714
		DB00341	881	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor N7.45C mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor N7.45C mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/nchembio714
		71449858	82246	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	582	9	1	6	4.8	O=C(O)CCCS(=O)(=O)c1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1	10.1016/j.bmcl.2012.08.124
		CHEMBL2171027	82246	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cellsDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells	ChEMBL	582	9	1	6	4.8	O=C(O)CCCS(=O)(=O)c1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1	10.1016/j.bmcl.2012.08.124
		11515125	8144	0	None	-	1	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	310	5	0	3	4.6	C[C@@H](c1cccnc1)c1c(CCN(C)C)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		CHEMBL1091778	8144	0	None	-	1	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	310	5	0	3	4.6	C[C@@H](c1cccnc1)c1c(CCN(C)C)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		127049855	140228	0	None	-13	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid scintillation counting method	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3805220	140228	0	None	-13	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid scintillation counting method	ChEMBL	368	7	3	4	3.1	N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		168282610	190916	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	802	20	5	7	4.1	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5185281	190916	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	802	20	5	7	4.1	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		2199935	119215	13	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	215	5	1	2	2.8	CNCCCOc1cccc2ccccc12	10.1021/jm2011589
		CHEMBL343324	119215	13	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	215	5	1	2	2.8	CNCCCOc1cccc2ccccc12	10.1021/jm2011589
		168282610	190916	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	802	20	5	7	4.1	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5185281	190916	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	802	20	5	7	4.1	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		10517956	56255	0	None	-66	2	Guinea pig	5.1	pKi	=	5.1	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	295	5	2	3	3.7	O=C(Nc1ccc2ccccc2c1)OCCCc1c[nH]cn1	10.1021/jm9507688
		CHEMBL16274	56255	0	None	-66	2	Guinea pig	5.1	pKi	=	5.1	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	295	5	2	3	3.7	O=C(Nc1ccc2ccccc2c1)OCCCc1c[nH]cn1	10.1021/jm9507688
		10833949	57191	0	None	-645	2	Guinea pig	5.1	pKi	=	5.1	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	385	6	2	3	2.9	O=C(NCc1ccc(I)cc1)OCCCc1c[nH]cn1	10.1021/jm9507688
		CHEMBL16496	57191	0	None	-645	2	Guinea pig	5.1	pKi	=	5.1	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	385	6	2	3	2.9	O=C(NCc1ccc(I)cc1)OCCCc1c[nH]cn1	10.1021/jm9507688
		168290235	192968	0	None	-12882	20	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5201074	192968	0	None	-12882	20	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222491	192968	0	None	-12882	20	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		10085839	204502	0	None	-251	3	Guinea pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]mepyramine bound to membranes of CHO cells expressing guinea pig H1 receptorsDisplacement of [3H]mepyramine bound to membranes of CHO cells expressing guinea pig H1 receptors	ChEMBL	294	7	3	2	2.9	S=C(NCCCCCc1c[nH]cn1)NC1CCCCC1	10.1021/jm00012a025
		CHEMBL72571	204502	0	None	-251	3	Guinea pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]mepyramine bound to membranes of CHO cells expressing guinea pig H1 receptorsDisplacement of [3H]mepyramine bound to membranes of CHO cells expressing guinea pig H1 receptors	ChEMBL	294	7	3	2	2.9	S=C(NCCCCCc1c[nH]cn1)NC1CCCCC1	10.1021/jm00012a025
		164617783	184590	0	None	-123	6	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	388	8	4	4	2.8	CCC(CNC(=O)/N=C(\N)NCCCc1sc(N)nc1C)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4848815	184590	0	None	-123	6	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	388	8	4	4	2.8	CCC(CNC(=O)/N=C(\N)NCCCc1sc(N)nc1C)c1ccccc1	10.1016/j.ejmech.2021.113190
		10541297	57549	0	None	-3090	2	Guinea pig	4.1	pKi	=	4.1	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	287	8	2	3	2.7	O=C(NCCCc1ccccc1)OCCCc1c[nH]cn1	10.1021/jm9507688
		CHEMBL16639	57549	0	None	-3090	2	Guinea pig	4.1	pKi	=	4.1	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	287	8	2	3	2.7	O=C(NCCCc1ccccc1)OCCCc1c[nH]cn1	10.1021/jm9507688
		10611565	98320	0	None	-3235	2	Guinea pig	4.1	pKi	=	4.1	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	263	5	2	3	2.7	O=C(Nc1ccc(F)cc1)OCCCc1c[nH]cn1	10.1021/jm9507688
		CHEMBL274989	98320	0	None	-3235	2	Guinea pig	4.1	pKi	=	4.1	Binding	Binding affinity against H1 receptor of Guinea pig ileumBinding affinity against H1 receptor of Guinea pig ileum	ChEMBL	263	5	2	3	2.7	O=C(Nc1ccc(F)cc1)OCCCc1c[nH]cn1	10.1021/jm9507688
		1204	1932	119	None	-501	24	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor S3.36T mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor S3.36T mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1038/nchembio714
		1247	1932	119	None	-501	24	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor S3.36T mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor S3.36T mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1038/nchembio714
		1375	1932	119	None	-501	24	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor S3.36T mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor S3.36T mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1038/nchembio714
		774	1932	119	None	-501	24	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor S3.36T mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor S3.36T mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1038/nchembio714
		CHEMBL90	1932	119	None	-501	24	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor S3.36T mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor S3.36T mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1038/nchembio714
		DB05381	1932	119	None	-501	24	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor S3.36T mutant expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor S3.36T mutant expressed in COS-7 cells by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1038/nchembio714
		1204	1932	119	None	-501	24	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]mepyramine from human wild-type histamine H1 receptor expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human wild-type histamine H1 receptor expressed in COS-7 cells by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1038/nchembio714
		1247	1932	119	None	-501	24	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]mepyramine from human wild-type histamine H1 receptor expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human wild-type histamine H1 receptor expressed in COS-7 cells by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1038/nchembio714
		1375	1932	119	None	-501	24	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]mepyramine from human wild-type histamine H1 receptor expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human wild-type histamine H1 receptor expressed in COS-7 cells by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1038/nchembio714
		774	1932	119	None	-501	24	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]mepyramine from human wild-type histamine H1 receptor expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human wild-type histamine H1 receptor expressed in COS-7 cells by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1038/nchembio714
		CHEMBL90	1932	119	None	-501	24	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]mepyramine from human wild-type histamine H1 receptor expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human wild-type histamine H1 receptor expressed in COS-7 cells by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1038/nchembio714
		DB05381	1932	119	None	-501	24	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]mepyramine from human wild-type histamine H1 receptor expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human wild-type histamine H1 receptor expressed in COS-7 cells by liquid scintillation counting	ChEMBL	111	2	2	2	-0.1	NCCc1cnc[nH]1	10.1038/nchembio714
		16093484	98060	6	None	-3	6	Human	8.1	pKi	=	8.1	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	229	0	2	3	2.6	CC1NC(N)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.080
		CHEMBL273170	98060	6	None	-3	6	Human	8.1	pKi	=	8.1	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	229	0	2	3	2.6	CC1NC(N)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.080
		137645406	157902	0	None	4	13	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-pyrilamine from recombinant human H1 receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-pyrilamine from recombinant human H1 receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	491	8	0	7	5.4	COc1ccccc1N1CCC2(CCN(CCCSc3nnc(-c4ccccc4)n3C)CC2)CC1	10.1021/acs.jmedchem.9b00412
		CHEMBL4084262	157902	0	None	4	13	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-pyrilamine from recombinant human H1 receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-pyrilamine from recombinant human H1 receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	491	8	0	7	5.4	COc1ccccc1N1CCC2(CCN(CCCSc3nnc(-c4ccccc4)n3C)CC2)CC1	10.1021/acs.jmedchem.9b00412
		46884153	8267	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	344	5	0	3	5.2	C[C@@H](c1ncccc1Cl)c1c(CCN(C)C)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		CHEMBL1092494	8267	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	344	5	0	3	5.2	C[C@@H](c1ncccc1Cl)c1c(CCN(C)C)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		53326726	57761	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	359	7	0	4	4.7	C[C@H](C1=C(CCN(C)Cc2ccco2)Cc2ccccc21)c1cnccn1	10.1016/j.bmcl.2010.12.053
		CHEMBL1669418	57761	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	359	7	0	4	4.7	C[C@H](C1=C(CCN(C)Cc2ccco2)Cc2ccccc21)c1cnccn1	10.1016/j.bmcl.2010.12.053
		135398737	958	93	None	-2	89	Guinea pig	8.1	pKi	=	8.1	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellumDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C4MD00578C
		38	958	93	None	-2	89	Guinea pig	8.1	pKi	=	8.1	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellumDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C4MD00578C
		722	958	93	None	-2	89	Guinea pig	8.1	pKi	=	8.1	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellumDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C4MD00578C
		CHEMBL42	958	93	None	-2	89	Guinea pig	8.1	pKi	=	8.1	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellumDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C4MD00578C
		DB00363	958	93	None	-2	89	Guinea pig	8.1	pKi	=	8.1	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellumDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C4MD00578C
		11846300	80266	3	None	2	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL213912	80266	3	None	2	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1	10.1016/j.bmcl.2015.12.035
		46889257	7528	0	None	301	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation counting	ChEMBL	350	5	0	5	3.2	COc1ccc(Cn2c(N3CC[C@@H](N(C)C)C3)nc3ccccc32)cc1	10.1016/j.bmcl.2010.03.027
		CHEMBL1087367	7528	0	None	301	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation counting	ChEMBL	350	5	0	5	3.2	COc1ccc(Cn2c(N3CC[C@@H](N(C)C)C3)nc3ccccc32)cc1	10.1016/j.bmcl.2010.03.027
		11140	2519	49	None	-9	3	Human	8.1	pKi	=	8.1	Binding	Radioligand Binding Assay: The pharmacological profile of metopimazine, metopimazine acid (MPZA), domperidone, and metoclopramide were assessed by radioligand binding and by a functional antagonist assay. For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in buffer. The assay was terminated by rapid filtration, and the bound radioactive signal was determined by liquid scintillation counting.Radioligand Binding Assay: The pharmacological profile of metopimazine, metopimazine acid (MPZA), domperidone, and metoclopramide were assessed by radioligand binding and by a functional antagonist assay. For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in buffer. The assay was terminated by rapid filtration, and the bound radioactive signal was determined by liquid scintillation counting.	ChEMBL	445	6	1	6	3.3	NC(=O)C1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)C	nan
		1784	2519	49	None	-9	3	Human	8.1	pKi	=	8.1	Binding	Radioligand Binding Assay: The pharmacological profile of metopimazine, metopimazine acid (MPZA), domperidone, and metoclopramide were assessed by radioligand binding and by a functional antagonist assay. For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in buffer. The assay was terminated by rapid filtration, and the bound radioactive signal was determined by liquid scintillation counting.Radioligand Binding Assay: The pharmacological profile of metopimazine, metopimazine acid (MPZA), domperidone, and metoclopramide were assessed by radioligand binding and by a functional antagonist assay. For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in buffer. The assay was terminated by rapid filtration, and the bound radioactive signal was determined by liquid scintillation counting.	ChEMBL	445	6	1	6	3.3	NC(=O)C1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)C	nan
		26388	2519	49	None	-9	3	Human	8.1	pKi	=	8.1	Binding	Radioligand Binding Assay: The pharmacological profile of metopimazine, metopimazine acid (MPZA), domperidone, and metoclopramide were assessed by radioligand binding and by a functional antagonist assay. For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in buffer. The assay was terminated by rapid filtration, and the bound radioactive signal was determined by liquid scintillation counting.Radioligand Binding Assay: The pharmacological profile of metopimazine, metopimazine acid (MPZA), domperidone, and metoclopramide were assessed by radioligand binding and by a functional antagonist assay. For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in buffer. The assay was terminated by rapid filtration, and the bound radioactive signal was determined by liquid scintillation counting.	ChEMBL	445	6	1	6	3.3	NC(=O)C1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)C	nan
		CHEMBL398615	2519	49	None	-9	3	Human	8.1	pKi	=	8.1	Binding	Radioligand Binding Assay: The pharmacological profile of metopimazine, metopimazine acid (MPZA), domperidone, and metoclopramide were assessed by radioligand binding and by a functional antagonist assay. For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in buffer. The assay was terminated by rapid filtration, and the bound radioactive signal was determined by liquid scintillation counting.Radioligand Binding Assay: The pharmacological profile of metopimazine, metopimazine acid (MPZA), domperidone, and metoclopramide were assessed by radioligand binding and by a functional antagonist assay. For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in buffer. The assay was terminated by rapid filtration, and the bound radioactive signal was determined by liquid scintillation counting.	ChEMBL	445	6	1	6	3.3	NC(=O)C1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)C	nan
		DB13591	2519	49	None	-9	3	Human	8.1	pKi	=	8.1	Binding	Radioligand Binding Assay: The pharmacological profile of metopimazine, metopimazine acid (MPZA), domperidone, and metoclopramide were assessed by radioligand binding and by a functional antagonist assay. For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in buffer. The assay was terminated by rapid filtration, and the bound radioactive signal was determined by liquid scintillation counting.Radioligand Binding Assay: The pharmacological profile of metopimazine, metopimazine acid (MPZA), domperidone, and metoclopramide were assessed by radioligand binding and by a functional antagonist assay. For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in buffer. The assay was terminated by rapid filtration, and the bound radioactive signal was determined by liquid scintillation counting.	ChEMBL	445	6	1	6	3.3	NC(=O)C1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)C	nan
		100	3805	58	None	-7	55	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		2637	3805	58	None	-7	55	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		5452	3805	58	None	-7	55	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		CHEMBL479	3805	58	None	-7	55	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		DB00679	3805	58	None	-7	55	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		1547484	940	74	None	-1	20	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		654	940	74	None	-1	20	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		9072	940	74	None	-1	20	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		CHEMBL43064	940	74	None	-1	20	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		DB00568	940	74	None	-1	20	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		2337	3256	77	None	1	62	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1016/j.bmc.2008.06.030
		50	3256	77	None	1	62	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1016/j.bmc.2008.06.030
		5002	3256	77	None	1	62	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1016/j.bmc.2008.06.030
		CHEMBL716	3256	77	None	1	62	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1016/j.bmc.2008.06.030
		DB01224	3256	77	None	1	62	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1016/j.bmc.2008.06.030
		49836295	18766	0	None	2	4	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation countingDisplacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation counting	ChEMBL	373	2	1	2	4.3	O=C(O)C1=CCCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
		CHEMBL1277935	18766	0	None	2	4	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation countingDisplacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation counting	ChEMBL	373	2	1	2	4.3	O=C(O)C1=CCCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
		51039225	57765	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	359	7	1	4	3.8	C[C@H](C1=C(CCN(C)Cc2ncc[nH]2)Cc2ccccc21)c1cnccn1	10.1016/j.bmcl.2010.12.053
		CHEMBL1669422	57765	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	359	7	1	4	3.8	C[C@H](C1=C(CCN(C)Cc2ncc[nH]2)Cc2ccccc21)c1cnccn1	10.1016/j.bmcl.2010.12.053
		46884669	8222	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	309	6	0	4	3.0	COc1ccc2c(c1)CC(CCN(C)C)=C2Cc1cnccn1	10.1016/j.bmcl.2010.02.055
		CHEMBL1092258	8222	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity at histamine H1 receptorBinding affinity at histamine H1 receptor	ChEMBL	309	6	0	4	3.0	COc1ccc2c(c1)CC(CCN(C)C)=C2Cc1cnccn1	10.1016/j.bmcl.2010.02.055
		9979272	207058	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	415	2	0	3	5.6	Cc1ncccc1CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/acs.jmedchem.9b00447
		CHEMBL91729	207058	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting methodDisplacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillation counting method	ChEMBL	415	2	0	3	5.6	Cc1ncccc1CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/acs.jmedchem.9b00447
		57394285	70458	0	None	-24	7	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-Pyrilamine from human histamine H1 receptor by liquid scintillation counterDisplacement of [3H]-Pyrilamine from human histamine H1 receptor by liquid scintillation counter	ChEMBL	378	6	0	3	5.2	Fc1ccc(SCCCN2CCCN(c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmc.2012.01.022
		CHEMBL1946125	70458	0	None	-24	7	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-Pyrilamine from human histamine H1 receptor by liquid scintillation counterDisplacement of [3H]-Pyrilamine from human histamine H1 receptor by liquid scintillation counter	ChEMBL	378	6	0	3	5.2	Fc1ccc(SCCCN2CCCN(c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmc.2012.01.022
		44334252	4548	0	None	-257	3	Human	4.1	pKi	=	4.1	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	449	10	3	7	1.7	CC(=O)c1ccc(OCCCN2CC[C@H](NC(=O)[C@@H](CO)NC(=O)OC(C)(C)C)C2)cc1	10.1016/s0960-894x(02)00685-6
		CHEMBL102390	4548	0	None	-257	3	Human	4.1	pKi	=	4.1	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	449	10	3	7	1.7	CC(=O)c1ccc(OCCCN2CC[C@H](NC(=O)[C@@H](CO)NC(=O)OC(C)(C)C)C2)cc1	10.1016/s0960-894x(02)00685-6
		14554123	118982	0	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	394	0	0	2	5.3	CC(C)(C)C(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/jm00105a069
		CHEMBL342455	118982	0	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	394	0	0	2	5.3	CC(C)(C)C(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1021/jm00105a069
		44335412	107459	0	None	1	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity at human cortical Histamine 1 receptorBinding affinity at human cortical Histamine 1 receptor	ChEMBL	413	8	0	6	3.8	CCOC(=O)N1CCN(CCCOc2ccc(-c3ccc([N+](=O)[O-])cc3)cc2)CC1	10.1016/s0960-894x(02)00648-0
		CHEMBL318320	107459	0	None	1	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity at human cortical Histamine 1 receptorBinding affinity at human cortical Histamine 1 receptor	ChEMBL	413	8	0	6	3.8	CCOC(=O)N1CCN(CCCOc2ccc(-c3ccc([N+](=O)[O-])cc3)cc2)CC1	10.1016/s0960-894x(02)00648-0
		162655663	180807	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity to H1 receptor (unknown origin)Binding affinity to H1 receptor (unknown origin)	ChEMBL	308	4	0	2	3.4	CN(C)CCCN1C(=O)c2ccccc2CCc2ccccc21	10.1016/j.bmcl.2020.127493
		CHEMBL4756695	180807	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity to H1 receptor (unknown origin)Binding affinity to H1 receptor (unknown origin)	ChEMBL	308	4	0	2	3.4	CN(C)CCCN1C(=O)c2ccccc2CCc2ccccc21	10.1016/j.bmcl.2020.127493
		44304284	163279	0	None	-20	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	426	9	0	6	3.5	CCOC(=O)N1CCN(CCCOc2ccc(C(=O)c3ccc(OC)cc3)cc2)CC1	10.1016/s0960-894x(02)00309-8
		CHEMBL418691	163279	0	None	-20	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	426	9	0	6	3.5	CCOC(=O)N1CCN(CCCOc2ccc(C(=O)c3ccc(OC)cc3)cc2)CC1	10.1016/s0960-894x(02)00309-8
		44304445	202988	0	None	-72	3	Human	5.1	pKi	=	5.1	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	531	14	1	6	5.3	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@H](CC(C)C)NC(=O)OC(C)(C)C)CC2)cc1	10.1016/s0960-894x(02)00310-4
		CHEMBL63112	202988	0	None	-72	3	Human	5.1	pKi	=	5.1	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	531	14	1	6	5.3	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@H](CC(C)C)NC(=O)OC(C)(C)C)CC2)cc1	10.1016/s0960-894x(02)00310-4
		44304752	203212	0	None	-3890	3	Human	5.1	pKi	=	5.1	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	459	9	1	6	3.1	C[C@@H](NC(=O)OC(C)(C)C)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		CHEMBL64406	203212	0	None	-3890	3	Human	5.1	pKi	=	5.1	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	459	9	1	6	3.1	C[C@@H](NC(=O)OC(C)(C)C)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		127036981	137450	0	None	1	2	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	399	5	1	5	3.6	CN1CCN(c2nc(NCCc3ccccc3)c3c(n2)-c2ccccc2CC3)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL3753621	137450	0	None	1	2	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	399	5	1	5	3.6	CN1CCN(c2nc(NCCc3ccccc3)c3c(n2)-c2ccccc2CC3)CC1	10.1016/j.bmcl.2015.12.035
		2421311	69032	3	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	302	5	1	5	3.4	NCCSc1nc(C2CCCCC2)n(-c2ccccc2)n1	10.1021/jm2011589
		CHEMBL1923534	69032	3	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting	ChEMBL	302	5	1	5	3.4	NCCSc1nc(C2CCCCC2)n(-c2ccccc2)n1	10.1021/jm2011589
		145988693	167166	0	None	-32	17	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]Pyrilamine from human H1 receptor expressed in HEK cells by radioligand binding assay	ChEMBL	524	7	1	3	7.1	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		CHEMBL4291048	167166	0	None	-32	17	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]Pyrilamine from human H1 receptor expressed in HEK cells by radioligand binding assay	ChEMBL	524	7	1	3	7.1	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		162662985	181979	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-pyrilamine from human H1 histamine receptor expressed in human HEK293 cellsDisplacement of [3H]-pyrilamine from human H1 histamine receptor expressed in human HEK293 cells	ChEMBL	414	5	1	3	5.3	C[C@H]1CN(CC[C@H]2CC[C@H](NC(=O)c3ccco3)CC2)CCc2ccc(Cl)cc21	10.1016/j.bmcl.2020.127681
		CHEMBL4780335	181979	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-pyrilamine from human H1 histamine receptor expressed in human HEK293 cellsDisplacement of [3H]-pyrilamine from human H1 histamine receptor expressed in human HEK293 cells	ChEMBL	414	5	1	3	5.3	C[C@H]1CN(CC[C@H]2CC[C@H](NC(=O)c3ccco3)CC2)CCc2ccc(Cl)cc21	10.1016/j.bmcl.2020.127681
		24740862	148008	0	None	-4	5	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	369	6	1	5	4.4	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1F	10.1016/j.bmcl.2009.09.024
		CHEMBL393436	148008	0	None	-4	5	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	369	6	1	5	4.4	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1F	10.1016/j.bmcl.2009.09.024
		127052467	140851	0	None	-23	7	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	1	1	4.5	c1ccc2c(c1)CCN(CCCCc1c[nH]c3ccccc13)C2	10.1016/j.bmc.2016.05.053
		CHEMBL3819494	140851	0	None	-23	7	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	1	1	4.5	c1ccc2c(c1)CCN(CCCCc1c[nH]c3ccccc13)C2	10.1016/j.bmc.2016.05.053
		168290238	191975	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	769	20	6	8	1.7	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5201159	191975	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	769	20	6	8	1.7	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168290238	191975	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	769	20	6	8	1.7	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5201159	191975	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	769	20	6	8	1.7	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		127052635	140207	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid scintillation counting method	ChEMBL	288	5	3	3	2.0	CC(C)CN/C(=N/C#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3805003	140207	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid scintillation counting method	ChEMBL	288	5	3	3	2.0	CC(C)CN/C(=N/C#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		127052467	140851	0	None	-23	7	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	1	1	4.5	c1ccc2c(c1)CCN(CCCCc1c[nH]c3ccccc13)C2	10.1016/j.bmc.2016.05.053
		CHEMBL3819494	140851	0	None	-23	7	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	1	1	4.5	c1ccc2c(c1)CCN(CCCCc1c[nH]c3ccccc13)C2	10.1016/j.bmc.2016.05.053
		11948707	166167	0	None	-2041	13	Human	6.1	pKi	=	6.1	Binding	Binding affinity to histamine H1 receptor by radioligand binding assayBinding affinity to histamine H1 receptor by radioligand binding assay	ChEMBL	373	7	0	8	0.6	COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1	10.1016/j.bmcl.2006.01.052
		CHEMBL426317	166167	0	None	-2041	13	Human	6.1	pKi	=	6.1	Binding	Binding affinity to histamine H1 receptor by radioligand binding assayBinding affinity to histamine H1 receptor by radioligand binding assay	ChEMBL	373	7	0	8	0.6	COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1	10.1016/j.bmcl.2006.01.052
		44361141	32801	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	340	3	0	2	4.1	CC(=O)N(C)CC/C=C1/c2ccc(Cl)cc2CCc2cccnc21	10.1021/jm00105a069
		CHEMBL141432	32801	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	ChEMBL	340	3	0	2	4.1	CC(=O)N(C)CC/C=C1/c2ccc(Cl)cc2CCc2cccnc21	10.1021/jm00105a069
		155559236	174852	0	None	-	1	Guinea pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysisDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysis	ChEMBL	318	6	0	4	1.8	CN1CCc2ccc(OCCCCN3CCOCC3)cc2C1=O	10.1016/j.bmcl.2019.04.015
		CHEMBL4563108	174852	0	None	-	1	Guinea pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysisDisplacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by Cheng and Prusoff equation analysis by scintillation counting analysis	ChEMBL	318	6	0	4	1.8	CN1CCc2ccc(OCCCCN3CCOCC3)cc2C1=O	10.1016/j.bmcl.2019.04.015
		27620	140818	13	None	-38	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	297	5	0	2	3.8	O=C(CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
		CHEMBL3818994	140818	13	None	-38	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]Pyrilamine from human H1 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	297	5	0	2	3.8	O=C(CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
		132060763	162861	0	None	-3	8	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-Pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	405	5	0	4	4.1	C=C(C)CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)CC3)CC1	10.1016/j.ejmech.2018.02.024
		CHEMBL4173095	162861	0	None	-3	8	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-Pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	405	5	0	4	4.1	C=C(C)CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)CC3)CC1	10.1016/j.ejmech.2018.02.024
		135409492	169170	50	None	1	3	Human	7.1	pKi	=	7.1	Binding	In vitro binding affinity of compound against histamine H1 neuronal receptorIn vitro binding affinity of compound against histamine H1 neuronal receptor	ChEMBL	328	0	1	5	3.5	Cc1cc2c(s1)Nc1ccccc1N=C2N1CC[N+](C)([O-])CC1	10.1016/S0960-894X(96)00567-7
		CHEMBL440512	169170	50	None	1	3	Human	7.1	pKi	=	7.1	Binding	In vitro binding affinity of compound against histamine H1 neuronal receptorIn vitro binding affinity of compound against histamine H1 neuronal receptor	ChEMBL	328	0	1	5	3.5	Cc1cc2c(s1)Nc1ccccc1N=C2N1CC[N+](C)([O-])CC1	10.1016/S0960-894X(96)00567-7
		44304307	203233	0	None	-134	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	388	12	0	4	4.2	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)CCC)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL64479	203233	0	None	-134	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	388	12	0	4	4.2	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)CCC)CC2)cc1	10.1016/s0960-894x(02)00309-8
		164610648	184838	0	None	-87	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	374	7	4	4	2.4	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC[C@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4852212	184838	0	None	-87	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	374	7	4	4	2.4	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC[C@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		164609729	185098	0	None	-1412	6	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	360	6	4	4	2.3	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)N[C@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4856059	185098	0	None	-1412	6	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	360	6	4	4	2.3	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)N[C@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		25218401	74945	0	None	-43651	3	Human	5.1	pKi	=	5.1	Binding	Binding affinity to H1 receptorBinding affinity to H1 receptor	ChEMBL	431	5	0	3	4.1	C[C@@H]1CCCN1CCN1CCc2cc(-c3ccc(C(=O)N4CCCC4)cc3)ccc2C1=O	10.1021/jm300011d
		CHEMBL2031885	74945	0	None	-43651	3	Human	5.1	pKi	=	5.1	Binding	Binding affinity to H1 receptorBinding affinity to H1 receptor	ChEMBL	431	5	0	3	4.1	C[C@@H]1CCCN1CCN1CCc2cc(-c3ccc(C(=O)N4CCCC4)cc3)ccc2C1=O	10.1021/jm300011d
		127048828	140320	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid scintillation counting method	ChEMBL	288	5	3	3	2.0	CC(C)CN/C(=N/C#N)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3806255	140320	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid scintillation counting method	ChEMBL	288	5	3	3	2.0	CC(C)CN/C(=N/C#N)NC[C@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		13091268	78224	0	None	-9549	14	Human	5.1	pKi	=	5.1	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	401	6	1	3	5.0	O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1	10.1016/j.bmc.2008.06.030
		CHEMBL210578	78224	0	None	-9549	14	Human	5.1	pKi	=	5.1	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	401	6	1	3	5.0	O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1	10.1016/j.bmc.2008.06.030
		13091268	78224	0	None	-9549	14	Human	5.1	pKi	=	5.1	Binding	Binding affinity to human cloned histamine H1 receptor by radioligand binding assayBinding affinity to human cloned histamine H1 receptor by radioligand binding assay	ChEMBL	401	6	1	3	5.0	O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1	10.1016/j.bmcl.2006.03.057
		CHEMBL210578	78224	0	None	-9549	14	Human	5.1	pKi	=	5.1	Binding	Binding affinity to human cloned histamine H1 receptor by radioligand binding assayBinding affinity to human cloned histamine H1 receptor by radioligand binding assay	ChEMBL	401	6	1	3	5.0	O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1	10.1016/j.bmcl.2006.03.057
		13091268	78224	0	None	-9549	14	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation countingDisplacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation counting	ChEMBL	401	6	1	3	5.0	O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
		CHEMBL210578	78224	0	None	-9549	14	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation countingDisplacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation counting	ChEMBL	401	6	1	3	5.0	O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
		2389	3331	118	None	-46	67	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human H1 receptorBinding affinity towards human H1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm0002432
		5073	3331	118	None	-46	67	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human H1 receptorBinding affinity towards human H1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm0002432
		96	3331	118	None	-46	67	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human H1 receptorBinding affinity towards human H1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm0002432
		CHEMBL85	3331	118	None	-46	67	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human H1 receptorBinding affinity towards human H1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm0002432
		DB00734	3331	118	None	-46	67	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human H1 receptorBinding affinity towards human H1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm0002432
		71459604	83793	0	None	-15	14	Human	5.1	pKi	=	5.1	Binding	Binding affinity to Histamine H1 receptorBinding affinity to Histamine H1 receptor	ChEMBL	309	4	1	3	2.0	COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1	10.1016/j.bmcl.2012.08.046
		CHEMBL2205811	83793	0	None	-15	14	Human	5.1	pKi	=	5.1	Binding	Binding affinity to Histamine H1 receptorBinding affinity to Histamine H1 receptor	ChEMBL	309	4	1	3	2.0	COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1	10.1016/j.bmcl.2012.08.046
		168288775	191446	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	785	21	7	9	0.7	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5193095	191446	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	785	21	7	9	0.7	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168288775	191446	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	785	21	7	9	0.7	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5193095	191446	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	785	21	7	9	0.7	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		9851785	51911	0	None	-371	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards histamine H1 receptor of human colon cells was determinedBinding affinity towards histamine H1 receptor of human colon cells was determined	ChEMBL	606	12	1	8	4.4	C[C@@H](NC(=O)c1ccc(N(C)C)cc1)C(=O)N1CCN(CCCOc2ccc(-c3noc(CC4CCCC4)n3)c(F)c2)CC1	10.1016/j.bmcl.2003.11.038
		CHEMBL158595	51911	0	None	-371	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards histamine H1 receptor of human colon cells was determinedBinding affinity towards histamine H1 receptor of human colon cells was determined	ChEMBL	606	12	1	8	4.4	C[C@@H](NC(=O)c1ccc(N(C)C)cc1)C(=O)N1CCN(CCCOc2ccc(-c3noc(CC4CCCC4)n3)c(F)c2)CC1	10.1016/j.bmcl.2003.11.038
		44334038	4462	0	None	-3162	3	Human	5.1	pKi	=	5.1	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	453	10	1	6	3.0	N#Cc1cccc(S(=O)(=O)N[C@H]2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)C2)c1	10.1016/s0960-894x(02)00685-6
		CHEMBL101748	4462	0	None	-3162	3	Human	5.1	pKi	=	5.1	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	453	10	1	6	3.0	N#Cc1cccc(S(=O)(=O)N[C@H]2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)C2)c1	10.1016/s0960-894x(02)00685-6
		127036980	137346	0	None	16	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	385	4	1	5	3.6	CN1CCN(c2nc(NCc3ccccc3)c3c(n2)-c2ccccc2CC3)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL3752885	137346	0	None	16	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	385	4	1	5	3.6	CN1CCN(c2nc(NCc3ccccc3)c3c(n2)-c2ccccc2CC3)CC1	10.1016/j.bmcl.2015.12.035
		44335405	5103	0	None	-75	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	321	6	1	4	2.9	N#Cc1ccc(-c2ccc(OCCCN3CCNCC3)cc2)cc1	10.1016/s0960-894x(02)00648-0
		CHEMBL105594	5103	0	None	-75	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity of human cortical histamine H1 receptorBinding affinity of human cortical histamine H1 receptor	ChEMBL	321	6	1	4	2.9	N#Cc1ccc(-c2ccc(OCCCN3CCNCC3)cc2)cc1	10.1016/s0960-894x(02)00648-0
		168283097	192893	0	None	-66	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	311	9	4	5	0.8	CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)o1	10.1021/acs.jmedchem.1c00692
		CHEMBL5186770	192893	0	None	-66	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	311	9	4	5	0.8	CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)o1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222043	192893	0	None	-66	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	311	9	4	5	0.8	CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)o1	10.1021/acs.jmedchem.1c00692
		168284480	192910	0	None	-66	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	330	6	4	4	1.3	Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCc1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5197548	192910	0	None	-66	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	330	6	4	4	1.3	Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCc1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222137	192910	0	None	-66	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	330	6	4	4	1.3	Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCc1ccccc1	10.1021/acs.jmedchem.1c00692
		44395530	67073	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsBinding affinity towards human histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	546	10	2	5	5.0	NC(=O)N(O)CCC#Cc1ccc(OCCCN2CCN([C@H](c3ccccc3)c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmcl.2004.08.060
		CHEMBL187264	67073	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsBinding affinity towards human histamine H1 receptor expressed in CHO-K1 cells	ChEMBL	546	10	2	5	5.0	NC(=O)N(O)CCC#Cc1ccc(OCCCN2CCN([C@H](c3ccccc3)c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmcl.2004.08.060
		10027435	47495	0	None	11	4	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptorDisplacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptor	ChEMBL	463	7	0	5	5.0	Cn1c(=O)sc2cc(CCCCN3CCN(Cc4ccc(Cl)c(Cl)c4)CC3)ccc21	10.1016/s0960-894x(02)00123-3
		CHEMBL15456	47495	0	None	11	4	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptorDisplacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptor	ChEMBL	463	7	0	5	5.0	Cn1c(=O)sc2cc(CCCCN3CCN(Cc4ccc(Cl)c(Cl)c4)CC3)ccc21	10.1016/s0960-894x(02)00123-3
		21474204	54774	0	None	3	4	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptorDisplacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptor	ChEMBL	394	7	0	4	4.9	Cn1c(=O)sc2cc(CCCCN3CCC(Cc4ccccc4)CC3)ccc21	10.1016/s0960-894x(02)00123-3
		CHEMBL16123	54774	0	None	3	4	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptorDisplacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptor	ChEMBL	394	7	0	4	4.9	Cn1c(=O)sc2cc(CCCCN3CCC(Cc4ccccc4)CC3)ccc21	10.1016/s0960-894x(02)00123-3
		10382839	116552	0	None	-	1	Guinea pig	8.1	pKi	=	8.1	Binding	Inhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptorInhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptor	ChEMBL	343	5	1	4	3.7	CN(C)CCSC1c2ccccc2COc2ccc(C(=O)O)cc21	10.1021/jm00055a013
		CHEMBL336317	116552	0	None	-	1	Guinea pig	8.1	pKi	=	8.1	Binding	Inhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptorInhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptor	ChEMBL	343	5	1	4	3.7	CN(C)CCSC1c2ccccc2COc2ccc(C(=O)O)cc21	10.1021/jm00055a013
		CHEMBL538750	116552	0	None	-	1	Guinea pig	8.1	pKi	=	8.1	Binding	Inhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptorInhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptor	ChEMBL	343	5	1	4	3.7	CN(C)CCSC1c2ccccc2COc2ccc(C(=O)O)cc21	10.1021/jm00055a013
		44326422	112393	0	None	1	3	Human	8.0	pKi	=	8.0	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	279	2	1	2	3.4	CNCC1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1	10.1016/j.bmcl.2004.03.069
		CHEMBL329685	112393	0	None	1	3	Human	8.0	pKi	=	8.0	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	279	2	1	2	3.4	CNCC1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1	10.1016/j.bmcl.2004.03.069
		11500781	8203	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	324	5	0	3	4.9	Cc1cccnc1[C@H](C)c1c(CCN(C)C)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		CHEMBL1092126	8203	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation countingDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting	ChEMBL	324	5	0	3	4.9	Cc1cccnc1[C@H](C)c1c(CCN(C)C)sc2ccccc12	10.1016/j.bmcl.2010.01.134
		10851717	78477	1	None	11	5	Rat	8.0	pKi	=	8.0	Binding	Half-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenateHalf-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN([C@@H]2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm010982y
		CHEMBL2111782	78477	1	None	11	5	Rat	8.0	pKi	=	8.0	Binding	Half-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenateHalf-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN([C@@H]2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm010982y
		44389292	63811	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity for human Histamine H1 receptor in CHO K1 cellsBinding affinity for human Histamine H1 receptor in CHO K1 cells	ChEMBL	605	12	1	6	6.5	CC(C)OC(=O)N(O)CCC#Cc1ccc(OCCCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1016/j.bmcl.2004.12.023
		CHEMBL180233	63811	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity for human Histamine H1 receptor in CHO K1 cellsBinding affinity for human Histamine H1 receptor in CHO K1 cells	ChEMBL	605	12	1	6	6.5	CC(C)OC(=O)N(O)CCC#Cc1ccc(OCCCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1016/j.bmcl.2004.12.023
		44326358	207302	0	None	3	3	Human	8.0	pKi	=	8.0	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	309	2	0	3	3.8	CN(C)CC1C[C@@H]2c3ccccc3OCc3ccccc3[C@H]2O1	10.1016/j.bmcl.2004.03.069
		CHEMBL93321	207302	0	None	3	3	Human	8.0	pKi	=	8.0	Binding	Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cellsAbility to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells	ChEMBL	309	2	0	3	3.8	CN(C)CC1C[C@@H]2c3ccccc3OCc3ccccc3[C@H]2O1	10.1016/j.bmcl.2004.03.069
		2398	954	62	None	-1	29	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		2801	954	62	None	-1	29	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		701	954	62	None	-1	29	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		CHEMBL415	954	62	None	-1	29	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		DB01242	954	62	None	-1	29	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		132356	14677	1	None	-	1	Guinea pig	8.0	pKi	=	8	Binding	Inhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptorInhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptor	ChEMBL	473	7	1	4	6.1	O=C(O)c1ccc2c(c1)C(SCCN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2	10.1021/jm00055a013
		CHEMBL1205688	14677	1	None	-	1	Guinea pig	8.0	pKi	=	8	Binding	Inhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptorInhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptor	ChEMBL	473	7	1	4	6.1	O=C(O)c1ccc2c(c1)C(SCCN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2	10.1021/jm00055a013
		CHEMBL133778	14677	1	None	-	1	Guinea pig	8.0	pKi	=	8	Binding	Inhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptorInhibition of the specific binding of [3H]pyrilamine to guinea pig cerebellum histamine H1 receptor	ChEMBL	473	7	1	4	6.1	O=C(O)c1ccc2c(c1)C(SCCN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2	10.1021/jm00055a013
		44334521	107836	0	None	-85	3	Human	4.1	pKi	=	4.1	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	262	6	1	4	1.7	CC(=O)c1ccc(OCCCN2CC[C@H](N)C2)cc1	10.1016/s0960-894x(02)00685-6
		CHEMBL319231	107836	0	None	-85	3	Human	4.1	pKi	=	4.1	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	262	6	1	4	1.7	CC(=O)c1ccc(OCCCN2CC[C@H](N)C2)cc1	10.1016/s0960-894x(02)00685-6
		53321511	57754	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	375	7	0	3	4.9	C[C@H](C1=C(CCN(C)CCC(F)(F)F)Cc2ccccc21)c1cnccn1	10.1016/j.bmcl.2010.12.053
		CHEMBL1669411	57754	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity to histamine H1 receptorBinding affinity to histamine H1 receptor	ChEMBL	375	7	0	3	4.9	C[C@H](C1=C(CCN(C)CCC(F)(F)F)Cc2ccccc21)c1cnccn1	10.1016/j.bmcl.2010.12.053
		44288847	165309	0	None	-64	5	Human	7.0	pKi	=	7.0	Binding	Selectivity screen against human Histamine H1 receptorSelectivity screen against human Histamine H1 receptor	ChEMBL	535	7	2	5	3.9	CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1	10.1016/s0960-894x(99)00696-4
		CHEMBL42335	165309	0	None	-64	5	Human	7.0	pKi	=	7.0	Binding	Selectivity screen against human Histamine H1 receptorSelectivity screen against human Histamine H1 receptor	ChEMBL	535	7	2	5	3.9	CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1	10.1016/s0960-894x(99)00696-4
		44334430	4454	0	None	-3019	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	428	10	1	5	3.1	O=C(c1ccc(OCCCN2CC[C@H](NS(=O)(=O)c3ccccc3)C2)cc1)C1CC1	10.1016/s0960-894x(02)00685-6
		CHEMBL101691	4454	0	None	-3019	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	428	10	1	5	3.1	O=C(c1ccc(OCCCN2CC[C@H](NS(=O)(=O)c3ccccc3)C2)cc1)C1CC1	10.1016/s0960-894x(02)00685-6
		44334234	109679	0	None	-9120	3	Human	4.0	pKi	=	4.0	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	432	10	1	7	1.8	Cn1cnc(S(=O)(=O)N[C@H]2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)C2)c1	10.1016/s0960-894x(02)00685-6
		CHEMBL322678	109679	0	None	-9120	3	Human	4.0	pKi	=	4.0	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	432	10	1	7	1.8	Cn1cnc(S(=O)(=O)N[C@H]2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)C2)c1	10.1016/s0960-894x(02)00685-6
		10065083	32103	1	None	-141	10	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	328	6	0	5	2.4	O=C(CCCN1CCN(c2ncccn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2008.06.030
		CHEMBL140872	32103	1	None	-141	10	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	328	6	0	5	2.4	O=C(CCCN1CCN(c2ncccn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2008.06.030
		10065083	32103	1	None	-141	10	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]pyrilamine from human H1 receptor by liquid scintillation countingDisplacement of [3H]pyrilamine from human H1 receptor by liquid scintillation counting	ChEMBL	328	6	0	5	2.4	O=C(CCCN1CCN(c2ncccn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2011.12.019
		CHEMBL140872	32103	1	None	-141	10	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]pyrilamine from human H1 receptor by liquid scintillation countingDisplacement of [3H]pyrilamine from human H1 receptor by liquid scintillation counting	ChEMBL	328	6	0	5	2.4	O=C(CCCN1CCN(c2ncccn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2011.12.019
		168273267	190499	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	698	17	5	7	2.2	C[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5179303	190499	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	698	17	5	7	2.2	C[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168273267	190499	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	698	17	5	7	2.2	C[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5179303	190499	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	698	17	5	7	2.2	C[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		25128822	187481	0	None	-1698	5	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	295	1	1	5	1.6	CN1CCN(c2nc(N)nc3c2CCc2ccccc2-3)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL494093	187481	0	None	-1698	5	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	295	1	1	5	1.6	CN1CCN(c2nc(N)nc3c2CCc2ccccc2-3)CC1	10.1016/j.bmcl.2015.12.035
		10201714	198714	0	None	-39	2	Rat	6.0	pKi	=	6.0	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	ChEMBL	411	10	3	3	4.3	O=C(NCCCCc1c[nH]cn1)NCCC(c1ccc(Cl)cc1)c1ccccn1	10.1016/s0960-894x(03)00357-3
		CHEMBL58239	198714	0	None	-39	2	Rat	6.0	pKi	=	6.0	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	ChEMBL	411	10	3	3	4.3	O=C(NCCCCc1c[nH]cn1)NCCC(c1ccc(Cl)cc1)c1ccccn1	10.1016/s0960-894x(03)00357-3
		44334395	4961	0	None	-2630	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	446	10	1	5	3.2	O=C(c1ccc(OCCCN2CC[C@H](NS(=O)(=O)c3ccc(F)cc3)C2)cc1)C1CC1	10.1016/s0960-894x(02)00685-6
		CHEMBL104808	4961	0	None	-2630	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	446	10	1	5	3.2	O=C(c1ccc(OCCCN2CC[C@H](NS(=O)(=O)c3ccc(F)cc3)C2)cc1)C1CC1	10.1016/s0960-894x(02)00685-6
		46882133	5808	0	None	-5	7	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	478	9	2	7	5.1	CCOc1cc(CN2CCC(Nc3nc4cc(NC(=O)C5CCC5)ccc4o3)CC2)ccc1OC	10.1016/j.bmcl.2009.09.024
		CHEMBL1078896	5808	0	None	-5	7	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	478	9	2	7	5.1	CCOc1cc(CN2CCC(Nc3nc4cc(NC(=O)C5CCC5)ccc4o3)CC2)ccc1OC	10.1016/j.bmcl.2009.09.024
		168294661	192402	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	764	19	6	8	2.2	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5207888	192402	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	764	19	6	8	2.2	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		44304079	202626	0	None	-128	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	376	9	0	5	3.5	CCOC(=O)N1CCN(CCCOc2ccc(C(=O)CC(C)C)cc2)CC1	10.1016/s0960-894x(02)00309-8
		CHEMBL61231	202626	0	None	-128	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	376	9	0	5	3.5	CCOC(=O)N1CCN(CCCOc2ccc(C(=O)CC(C)C)cc2)CC1	10.1016/s0960-894x(02)00309-8
		44304035	203309	0	None	-13	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	410	9	0	5	3.7	CCOC(=O)N1CCN(CCCOc2ccc(C(=O)Cc3ccccc3)cc2)CC1	10.1016/s0960-894x(02)00309-8
		CHEMBL64799	203309	0	None	-13	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	410	9	0	5	3.7	CCOC(=O)N1CCN(CCCOc2ccc(C(=O)Cc3ccccc3)cc2)CC1	10.1016/s0960-894x(02)00309-8
		168294661	192402	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	764	19	6	8	2.2	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5207888	192402	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	764	19	6	8	2.2	C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		44304312	162787	0	None	-316	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	453	10	1	5	2.9	N[C@H](Cc1ccc(F)cc1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		CHEMBL417215	162787	0	None	-316	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	453	10	1	5	2.9	N[C@H](Cc1ccc(F)cc1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		44304349	202801	0	None	-173	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	566	14	1	7	4.9	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@H](Cc3ccncc3)NC(=O)OC(C)(C)C)CC2)cc1	10.1016/s0960-894x(02)00310-4
		CHEMBL62266	202801	0	None	-173	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	566	14	1	7	4.9	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@H](Cc3ccncc3)NC(=O)OC(C)(C)C)CC2)cc1	10.1016/s0960-894x(02)00310-4
		127036979	137488	0	None	-1	2	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	399	5	1	5	3.6	CN1CCN(c2nc(NCCc3ccccc3)nc3c2CCc2ccccc2-3)CC1	10.1016/j.bmcl.2015.12.035
		CHEMBL3753962	137488	0	None	-1	2	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingDisplacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting	ChEMBL	399	5	1	5	3.6	CN1CCN(c2nc(NCCc3ccccc3)nc3c2CCc2ccccc2-3)CC1	10.1016/j.bmcl.2015.12.035
		127052292	140266	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid scintillation counting method	ChEMBL	350	7	3	3	2.9	N#C/N=C(/NCCCc1ccccc1)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		CHEMBL3805663	140266	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid scintillation counting method	ChEMBL	350	7	3	3	2.9	N#C/N=C(/NCCCc1ccccc1)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1	10.1021/acs.jmedchem.6b00120
		50878551	90745	61	None	-21	18	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
		CHEMBL2391541	90745	61	None	-21	18	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
		44334396	4916	0	None	-3467	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	446	10	1	5	3.2	O=C(c1ccc(OCCCN2CC[C@H](NS(=O)(=O)c3ccccc3F)C2)cc1)C1CC1	10.1016/s0960-894x(02)00685-6
		CHEMBL104618	4916	0	None	-3467	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity to the human Histamine H1 receptorBinding affinity to the human Histamine H1 receptor	ChEMBL	446	10	1	5	3.2	O=C(c1ccc(OCCCN2CC[C@H](NS(=O)(=O)c3ccccc3F)C2)cc1)C1CC1	10.1016/s0960-894x(02)00685-6
		44582676	189779	0	None	-7	17	Human	6.0	pKi	=	6.0	Binding	Inhibition of human cloned histamine H1 receptor by competitive binding experimentInhibition of human cloned histamine H1 receptor by competitive binding experiment	ChEMBL	403	9	0	4	4.3	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		CHEMBL516088	189779	0	None	-7	17	Human	6.0	pKi	=	6.0	Binding	Inhibition of human cloned histamine H1 receptor by competitive binding experimentInhibition of human cloned histamine H1 receptor by competitive binding experiment	ChEMBL	403	9	0	4	4.3	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		168274424	190131	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	834	21	7	9	2.8	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5173453	190131	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	834	21	7	9	2.8	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168297312	192526	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	785	21	7	9	0.7	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5209546	192526	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	785	21	7	9	0.7	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168274424	190131	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	834	21	7	9	2.8	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5173453	190131	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	834	21	7	9	2.8	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168297312	192526	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	785	21	7	9	0.7	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		CHEMBL5209546	192526	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assayDisplacement of fluorophore-labeled mepyramine from Nluc-tagged human H1R expressed in HEK293T cells incubated for 2 hrs by NanoBRET competition binding assay	ChEMBL	785	21	7	9	0.7	CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.2c00125
		168278471	192848	0	None	-229	6	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	312	8	4	4	1.5	CCCCCNC(=O)/N=C(\N)NCCCc1cnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5183205	192848	0	None	-229	6	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	312	8	4	4	1.5	CCCCCNC(=O)/N=C(\N)NCCCc1cnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5221757	192848	0	None	-229	6	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysisDisplacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis	ChEMBL	312	8	4	4	1.5	CCCCCNC(=O)/N=C(\N)NCCCc1cnc(N)s1	10.1021/acs.jmedchem.1c00692
		164622886	185942	0	None	-93	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	374	7	4	4	2.4	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC[C@@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		CHEMBL4869389	185942	0	None	-93	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting methodDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by microbeta scintillation counting method	ChEMBL	374	7	4	4	2.4	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC[C@@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
		44304332	201344	0	None	-20417	3	Human	4.0	pKi	=	4.0	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	399	9	1	5	2.3	O=C(c1ccc(OCCCN2CCN(C(=O)C[C@H]3CCCN3)CC2)cc1)C1CC1	10.1016/s0960-894x(02)00310-4
		CHEMBL60435	201344	0	None	-20417	3	Human	4.0	pKi	=	4.0	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	399	9	1	5	2.3	O=C(c1ccc(OCCCN2CCN(C(=O)C[C@H]3CCCN3)CC2)cc1)C1CC1	10.1016/s0960-894x(02)00310-4
		44304719	202722	0	None	-20892	3	Human	4.0	pKi	=	4.0	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	425	10	2	6	1.5	N[C@H](Cc1c[nH]cn1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		CHEMBL61792	202722	0	None	-20892	3	Human	4.0	pKi	=	4.0	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	425	10	2	6	1.5	N[C@H](Cc1c[nH]cn1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		135559170	102060	0	None	-1479	7	Guinea pig	6.0	pKi	=	6.0	Binding	Compound is evaluated for binding affinity towards Histamine H1 receptor using [3H]pyrilamine in guinea pig lungCompound is evaluated for binding affinity towards Histamine H1 receptor using [3H]pyrilamine in guinea pig lung	ChEMBL	391	4	1	5	2.5	COc1ccccc1N1CCN(CC2CN3C(=O)Nc4ccccc4C3=N2)CC1	10.1021/jm970159v
		CHEMBL302021	102060	0	None	-1479	7	Guinea pig	6.0	pKi	=	6.0	Binding	Compound is evaluated for binding affinity towards Histamine H1 receptor using [3H]pyrilamine in guinea pig lungCompound is evaluated for binding affinity towards Histamine H1 receptor using [3H]pyrilamine in guinea pig lung	ChEMBL	391	4	1	5	2.5	COc1ccccc1N1CCN(CC2CN3C(=O)Nc4ccccc4C3=N2)CC1	10.1021/jm970159v
		25218143	74933	0	None	-5011	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity to H1 receptorBinding affinity to H1 receptor	ChEMBL	431	6	1	3	4.1	O=C(NC1CCCC1)c1ccc(-c2ccc3c(c2)CCN(CCN2CCCC2)C3=O)cc1	10.1021/jm300011d
		CHEMBL2031873	74933	0	None	-5011	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity to H1 receptorBinding affinity to H1 receptor	ChEMBL	431	6	1	3	4.1	O=C(NC1CCCC1)c1ccc(-c2ccc3c(c2)CCN(CCN2CCCC2)C3=O)cc1	10.1021/jm300011d
		46216789	200328	0	None	-2	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]Pyrilamine from human cloned histamine H1 receptorDisplacement of [3H]Pyrilamine from human cloned histamine H1 receptor	ChEMBL	341	7	1	1	5.3	c1ccc(CCCCNCC2c3ccccc3Cc3ccccc32)cc1	10.1016/j.bmcl.2009.12.064
		CHEMBL597528	200328	0	None	-2	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]Pyrilamine from human cloned histamine H1 receptorDisplacement of [3H]Pyrilamine from human cloned histamine H1 receptor	ChEMBL	341	7	1	1	5.3	c1ccc(CCCCNCC2c3ccccc3Cc3ccccc32)cc1	10.1016/j.bmcl.2009.12.064
		44304270	201248	0	None	-6	3	Human	7.0	pKi	=	7.0	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	442	11	0	5	5.0	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3ccc(C)s3)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL60383	201248	0	None	-6	3	Human	7.0	pKi	=	7.0	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	442	11	0	5	5.0	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3ccc(C)s3)CC2)cc1	10.1016/s0960-894x(02)00309-8
		25147771	174238	0	None	-3	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in NIH3T3 cellsDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in NIH3T3 cells	ChEMBL	357	4	1	6	3.2	CN1CCN(c2nc(NCc3ccoc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		CHEMBL454890	174238	0	None	-3	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]mepyramine from human histamine H1 receptor expressed in NIH3T3 cellsDisplacement of [3H]mepyramine from human histamine H1 receptor expressed in NIH3T3 cells	ChEMBL	357	4	1	6	3.2	CN1CCN(c2nc(NCc3ccoc3)c3cc(Cl)ccc3n2)CC1	10.1021/jm800876b
		44343936	11059	0	None	-	1	Rat	6.0	pKi	=	6.0	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	369	1	0	3	3.5	CC(=O)N1CCCN(C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/s0960-894x(98)00626-x
		CHEMBL117745	11059	0	None	-	1	Rat	6.0	pKi	=	6.0	Binding	Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesBinding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes	ChEMBL	369	1	0	3	3.5	CC(=O)N1CCCN(C2c3ccc(Cl)cc3CCc3cccnc32)CC1	10.1016/s0960-894x(98)00626-x
		44350664	118149	0	None	-9	6	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	351	6	0	2	5.2	O=C(CCCN1C2CCC1CC(c1ccccc1)C2)c1ccc(F)cc1	10.1016/j.bmc.2008.06.030
		CHEMBL340816	118149	0	None	-9	6	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	351	6	0	2	5.2	O=C(CCCN1C2CCC1CC(c1ccccc1)C2)c1ccc(F)cc1	10.1016/j.bmc.2008.06.030
		CHEMBL553417	118149	0	None	-9	6	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	ChEMBL	351	6	0	2	5.2	O=C(CCCN1C2CCC1CC(c1ccccc1)C2)c1ccc(F)cc1	10.1016/j.bmc.2008.06.030
		13091359	113539	0	None	-1380	10	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation countingDisplacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
		CHEMBL3321790	113539	0	None	-1380	10	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation countingDisplacement of [3H]Pyrilamine from human histamine H1 receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
		44304036	96782	0	None	-17	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	360	8	0	5	3.0	C=C(C)C(=O)c1ccc(OCCCN2CCN(C(=O)OCC)CC2)cc1	10.1016/s0960-894x(02)00309-8
		CHEMBL264761	96782	0	None	-17	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity for the human Histamine H1 ReceptorBinding affinity for the human Histamine H1 Receptor	ChEMBL	360	8	0	5	3.0	C=C(C)C(=O)c1ccc(OCCCN2CCN(C(=O)OCC)CC2)cc1	10.1016/s0960-894x(02)00309-8
		1278	2150	84	None	-1778	8	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8007618
		1279	2150	84	None	-1778	8	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8007618
		4908365	2150	84	None	-1778	8	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8007618
		CHEMBL129198	2150	84	None	-1778	8	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	ChEMBL	277	1	1	2	2.2	CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl	10.1021/jm8007618
		44304743	100609	0	None	-57	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	431	13	1	5	3.7	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@@H](N)CC(C)C)CC2)cc1	10.1016/s0960-894x(02)00310-4
		CHEMBL291847	100609	0	None	-57	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	431	13	1	5	3.7	CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@@H](N)CC(C)C)CC2)cc1	10.1016/s0960-894x(02)00310-4
		44304064	102810	0	None	-323	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	451	10	2	6	2.5	N[C@H](Cc1ccc(O)cc1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		CHEMBL305371	102810	0	None	-323	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	451	10	2	6	2.5	N[C@H](Cc1ccc(O)cc1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		44304313	201585	0	None	-426	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	441	10	1	6	2.8	N[C@H](Cc1ccsc1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		CHEMBL60559	201585	0	None	-426	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity towards Histamine H1 receptor of human membranes.Binding affinity towards Histamine H1 receptor of human membranes.	ChEMBL	441	10	1	6	2.8	N[C@H](Cc1ccsc1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1	10.1016/s0960-894x(02)00310-4
		11525848	114591	31	None	-	1	Human	7.0	pKi	=	7.0	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000729a HRH1Selectivity interaction (GPCR panel (PDSP screen)) EUB0000729a HRH1	ChEMBL	479	9	3	7	3.3	COc1cccc(CNC(=O)c2nc3scc(COCc4ccc(C(=O)O)cc4)c3c(=O)[nH]2)c1	10.6019/CHEMBL5212743
		CHEMBL3337894	114591	31	None	-	1	Human	7.0	pKi	=	7.0	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000729a HRH1Selectivity interaction (GPCR panel (PDSP screen)) EUB0000729a HRH1	ChEMBL	479	9	3	7	3.3	COc1cccc(CNC(=O)c2nc3scc(COCc4ccc(C(=O)O)cc4)c3c(=O)[nH]2)c1	10.6019/CHEMBL5212743
		130442572	171908	0	None	-208	24	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4469848	171908	0	None	-208	24	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		1164	1630	26	None	-	12	Rat	8.3	pIC50	=	8.3	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	Drug Central	336	6	0	2	4.1	CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
		1626	1630	26	None	-	12	Rat	8.3	pIC50	=	8.3	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	Drug Central	336	6	0	2	4.1	CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
		3345	1630	26	None	-	12	Rat	8.3	pIC50	=	8.3	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	Drug Central	336	6	0	2	4.1	CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
		CHEMBL596	1630	26	None	-	12	Rat	8.3	pIC50	=	8.3	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	Drug Central	336	6	0	2	4.1	CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
		DB00813	1630	26	None	-	12	Rat	8.3	pIC50	=	8.3	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	Drug Central	336	6	0	2	4.1	CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
		2031	120433	31	None	-	0	Rat	8.3	pIC50	=	8.3	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	Drug Central	311	8	0	3	3.7	CCN(CC)CCOC(=O)C(c1ccccc1)c1ccccc1	None
		CHEMBL353846	120433	31	None	-	0	Rat	8.3	pIC50	=	8.3	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	Drug Central	311	8	0	3	3.7	CCN(CC)CCOC(=O)C(c1ccccc1)c1ccccc1	None
		2142	3096	58	None	-7585	36	Rat	8.3	pIC50	=	8.3	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4920903	3096	58	None	-7585	36	Rat	8.3	pIC50	=	8.3	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		502	3096	58	None	-7585	36	Rat	8.3	pIC50	=	8.3	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		5775	3096	58	None	-7585	36	Rat	8.3	pIC50	=	8.3	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		CHEMBL597	3096	58	None	-7585	36	Rat	8.3	pIC50	=	8.3	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		DB00692	3096	58	None	-7585	36	Rat	8.3	pIC50	=	8.3	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4919	206234	23	None	-	8	Rat	8.3	pIC50	=	8.3	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	Drug Central	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	None
		CHEMBL86715	206234	23	None	-	8	Rat	8.3	pIC50	=	8.3	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	Drug Central	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	None
		2284	3182	33	None	-10	29	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		4926	3182	33	None	-10	29	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		7281	3182	33	None	-10	29	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		CHEMBL564	3182	33	None	-10	29	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		DB00420	3182	33	None	-10	29	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		1613	2348	53	None	-	44	Rat	8.2	pIC50	=	8.2	Binding	Binding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligandBinding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligand	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	2348	53	None	-	44	Rat	8.2	pIC50	=	8.2	Binding	Binding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligandBinding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligand	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	2348	53	None	-	44	Rat	8.2	pIC50	=	8.2	Binding	Binding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligandBinding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligand	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	2348	53	None	-	44	Rat	8.2	pIC50	=	8.2	Binding	Binding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligandBinding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligand	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	2348	53	None	-	44	Rat	8.2	pIC50	=	8.2	Binding	Binding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligandBinding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligand	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3689	102771	55	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Compound was tested for the binding affinity against histamine H1 receptor by using [3H]mepyramine as radioligandCompound was tested for the binding affinity against histamine H1 receptor by using [3H]mepyramine as radioligand	Drug Central	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	None
		CHEMBL1372983	102771	55	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Compound was tested for the binding affinity against histamine H1 receptor by using [3H]mepyramine as radioligandCompound was tested for the binding affinity against histamine H1 receptor by using [3H]mepyramine as radioligand	Drug Central	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	None
		CHEMBL305187	102771	55	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Compound was tested for the binding affinity against histamine H1 receptor by using [3H]mepyramine as radioligandCompound was tested for the binding affinity against histamine H1 receptor by using [3H]mepyramine as radioligand	Drug Central	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	None
		4601	206747	35	None	-	16	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	Drug Central	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
		CHEMBL1201023	206747	35	None	-	16	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	Drug Central	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
		CHEMBL900	206747	35	None	-	16	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	Drug Central	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
		2865	4143	73	None	-1047	53	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	4143	73	None	-1047	53	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	4143	73	None	-1047	53	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	4143	73	None	-1047	53	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	4143	73	None	-1047	53	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		100	3805	58	None	-23	55	Rat	8.2	pIC50	=	8.2	Binding	Binding affinity against Histamine H1 receptor was measured using radioligand ([3H]pyrilamine) binding assayBinding affinity against Histamine H1 receptor was measured using radioligand ([3H]pyrilamine) binding assay	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	3805	58	None	-23	55	Rat	8.2	pIC50	=	8.2	Binding	Binding affinity against Histamine H1 receptor was measured using radioligand ([3H]pyrilamine) binding assayBinding affinity against Histamine H1 receptor was measured using radioligand ([3H]pyrilamine) binding assay	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	3805	58	None	-23	55	Rat	8.2	pIC50	=	8.2	Binding	Binding affinity against Histamine H1 receptor was measured using radioligand ([3H]pyrilamine) binding assayBinding affinity against Histamine H1 receptor was measured using radioligand ([3H]pyrilamine) binding assay	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	3805	58	None	-23	55	Rat	8.2	pIC50	=	8.2	Binding	Binding affinity against Histamine H1 receptor was measured using radioligand ([3H]pyrilamine) binding assayBinding affinity against Histamine H1 receptor was measured using radioligand ([3H]pyrilamine) binding assay	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	3805	58	None	-23	55	Rat	8.2	pIC50	=	8.2	Binding	Binding affinity against Histamine H1 receptor was measured using radioligand ([3H]pyrilamine) binding assayBinding affinity against Histamine H1 receptor was measured using radioligand ([3H]pyrilamine) binding assay	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2389	3331	118	None	-346	67	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	None	-346	67	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	None	-346	67	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	None	-346	67	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	None	-346	67	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		3191	102858	97	None	-	25	Guinea pig	8.1	pIC50	=	8.1	Binding	Compound is evaluated for in vitro receptor binding affinity against H1 receptorCompound is evaluated for in vitro receptor binding affinity against H1 receptor	Drug Central	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	None
		CHEMBL305660	102858	97	None	-	25	Guinea pig	8.1	pIC50	=	8.1	Binding	Compound is evaluated for in vitro receptor binding affinity against H1 receptorCompound is evaluated for in vitro receptor binding affinity against H1 receptor	Drug Central	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	None
		2337	3256	77	None	-1	62	Rat	8.1	pIC50	=	8.1	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	None	-1	62	Rat	8.1	pIC50	=	8.1	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	None	-1	62	Rat	8.1	pIC50	=	8.1	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	None	-1	62	Rat	8.1	pIC50	=	8.1	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	None	-1	62	Rat	8.1	pIC50	=	8.1	Binding	Displacement of [3H]mepyramine from H1R in rat brainDisplacement of [3H]mepyramine from H1R in rat brain	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		1385580	29276	76	None	-	5	Guinea pig	8.1	pIC50	=	8.1	Binding	Inhibitory activity against Tritiated [3H]- mepyramine binding to Histamine H1 receptor in guinea pig cerebral cortexInhibitory activity against Tritiated [3H]- mepyramine binding to Histamine H1 receptor in guinea pig cerebral cortex	Drug Central	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	None
		4615	29276	76	None	-	5	Guinea pig	8.1	pIC50	=	8.1	Binding	Inhibitory activity against Tritiated [3H]- mepyramine binding to Histamine H1 receptor in guinea pig cerebral cortexInhibitory activity against Tritiated [3H]- mepyramine binding to Histamine H1 receptor in guinea pig cerebral cortex	Drug Central	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	None
		CHEMBL13828	29276	76	None	-	5	Guinea pig	8.1	pIC50	=	8.1	Binding	Inhibitory activity against Tritiated [3H]- mepyramine binding to Histamine H1 receptor in guinea pig cerebral cortexInhibitory activity against Tritiated [3H]- mepyramine binding to Histamine H1 receptor in guinea pig cerebral cortex	Drug Central	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	None
		1210	918	51	None	9	21	Guinea pig	8.1	pIC50	=	8.1	Binding	Inhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortex	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		1213	918	51	None	9	21	Guinea pig	8.1	pIC50	=	8.1	Binding	Inhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortex	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		2725	918	51	None	9	21	Guinea pig	8.1	pIC50	=	8.1	Binding	Inhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortex	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		33036	918	51	None	9	21	Guinea pig	8.1	pIC50	=	8.1	Binding	Inhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortex	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		4411	918	51	None	9	21	Guinea pig	8.1	pIC50	=	8.1	Binding	Inhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortex	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		616	918	51	None	9	21	Guinea pig	8.1	pIC50	=	8.1	Binding	Inhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortex	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		6976	918	51	None	9	21	Guinea pig	8.1	pIC50	=	8.1	Binding	Inhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortex	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		716121	918	51	None	9	21	Guinea pig	8.1	pIC50	=	8.1	Binding	Inhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortex	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL1201353	918	51	None	9	21	Guinea pig	8.1	pIC50	=	8.1	Binding	Inhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortex	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL1554789	918	51	None	9	21	Guinea pig	8.1	pIC50	=	8.1	Binding	Inhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortex	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL505	918	51	None	9	21	Guinea pig	8.1	pIC50	=	8.1	Binding	Inhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortex	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		DB01114	918	51	None	9	21	Guinea pig	8.1	pIC50	=	8.1	Binding	Inhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortex	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		DB13679	918	51	None	9	21	Guinea pig	8.1	pIC50	=	8.1	Binding	Inhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortexInhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortex	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		1227	2489	43	None	-5	12	Rat	8.1	pIC50	=	8.1	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		2331	2489	43	None	-5	12	Rat	8.1	pIC50	=	8.1	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		3957	2489	43	None	-5	12	Rat	8.1	pIC50	=	8.1	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		4992	2489	43	None	-5	12	Rat	8.1	pIC50	=	8.1	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		CHEMBL511	2489	43	None	-5	12	Rat	8.1	pIC50	=	8.1	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		DB06691	2489	43	None	-5	12	Rat	8.1	pIC50	=	8.1	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		11976	920	59	None	-	24	Rat	8.1	pIC50	=	8.1	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		667467	920	59	None	-	24	Rat	8.1	pIC50	=	8.1	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		CHEMBL908	920	59	None	-	24	Rat	8.1	pIC50	=	8.1	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		DB01239	920	59	None	-	24	Rat	8.1	pIC50	=	8.1	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingDisplacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		1027	1576	73	None	-6	2	Human	7.6	pIC50	=	7.6	Binding	Antagonism of 5 nM [<sup>3</sup>H]mepyramine binding in an intact cell assay using U373 MG astrocytoma cells.Antagonism of 5 nM [<sup>3</sup>H]mepyramine binding in an intact cell assay using U373 MG astrocytoma cells.	Guide to Pharmacology	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	18446005
		3241	1576	73	None	-6	2	Human	7.6	pIC50	=	7.6	Binding	Antagonism of 5 nM [<sup>3</sup>H]mepyramine binding in an intact cell assay using U373 MG astrocytoma cells.Antagonism of 5 nM [<sup>3</sup>H]mepyramine binding in an intact cell assay using U373 MG astrocytoma cells.	Guide to Pharmacology	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	18446005
		7176	1576	73	None	-6	2	Human	7.6	pIC50	=	7.6	Binding	Antagonism of 5 nM [<sup>3</sup>H]mepyramine binding in an intact cell assay using U373 MG astrocytoma cells.Antagonism of 5 nM [<sup>3</sup>H]mepyramine binding in an intact cell assay using U373 MG astrocytoma cells.	Guide to Pharmacology	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	18446005
		CHEMBL1106	1576	73	None	-6	2	Human	7.6	pIC50	=	7.6	Binding	Antagonism of 5 nM [<sup>3</sup>H]mepyramine binding in an intact cell assay using U373 MG astrocytoma cells.Antagonism of 5 nM [<sup>3</sup>H]mepyramine binding in an intact cell assay using U373 MG astrocytoma cells.	Guide to Pharmacology	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	18446005
		DB00751	1576	73	None	-6	2	Human	7.6	pIC50	=	7.6	Binding	Antagonism of 5 nM [<sup>3</sup>H]mepyramine binding in an intact cell assay using U373 MG astrocytoma cells.Antagonism of 5 nM [<sup>3</sup>H]mepyramine binding in an intact cell assay using U373 MG astrocytoma cells.	Guide to Pharmacology	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	18446005
		10102	2546	88	None	-	1	Guinea pig	7.3	pIC50	=	7.3	Binding	Inhibition of [3H]pyrilamine binding to histamine H1 receptors in guinea pig cerebellar membranes and sections.Inhibition of [3H]pyrilamine binding to histamine H1 receptors in guinea pig cerebellar membranes and sections.	Guide to Pharmacology	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	7612054
		1824	2546	88	None	-	1	Guinea pig	7.3	pIC50	=	7.3	Binding	Inhibition of [3H]pyrilamine binding to histamine H1 receptors in guinea pig cerebellar membranes and sections.Inhibition of [3H]pyrilamine binding to histamine H1 receptors in guinea pig cerebellar membranes and sections.	Guide to Pharmacology	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	7612054
		65906	2546	88	None	-	1	Guinea pig	7.3	pIC50	=	7.3	Binding	Inhibition of [3H]pyrilamine binding to histamine H1 receptors in guinea pig cerebellar membranes and sections.Inhibition of [3H]pyrilamine binding to histamine H1 receptors in guinea pig cerebellar membranes and sections.	Guide to Pharmacology	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	7612054
		CHEMBL94454	2546	88	None	-	1	Guinea pig	7.3	pIC50	=	7.3	Binding	Inhibition of [3H]pyrilamine binding to histamine H1 receptors in guinea pig cerebellar membranes and sections.Inhibition of [3H]pyrilamine binding to histamine H1 receptors in guinea pig cerebellar membranes and sections.	Guide to Pharmacology	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	7612054
		DB12523	2546	88	None	-	1	Guinea pig	7.3	pIC50	=	7.3	Binding	Inhibition of [3H]pyrilamine binding to histamine H1 receptors in guinea pig cerebellar membranes and sections.Inhibition of [3H]pyrilamine binding to histamine H1 receptors in guinea pig cerebellar membranes and sections.	Guide to Pharmacology	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	7612054
		2200	20203	61	None	26	2	Guinea pig	8.2	pKd	=	8.2	Binding	Antagonist activity at H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced ileum contraction measured after 15 minsAntagonist activity at H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced ileum contraction measured after 15 mins	Drug Central	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	None
		CHEMBL1256819	20203	61	None	26	2	Guinea pig	8.2	pKd	=	8.2	Binding	Antagonist activity at H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced ileum contraction measured after 15 minsAntagonist activity at H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced ileum contraction measured after 15 mins	Drug Central	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	None
		CHEMBL1305	20203	61	None	26	2	Guinea pig	8.2	pKd	=	8.2	Binding	Antagonist activity at H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced ileum contraction measured after 15 minsAntagonist activity at H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced ileum contraction measured after 15 mins	Drug Central	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	None
		1605	2342	117	None	1	4	Guinea pig	8.2	pKd	=	8.2	Binding	NoneNone	Drug Central	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	None
		3957	2342	117	None	1	4	Guinea pig	8.2	pKd	=	8.2	Binding	NoneNone	Drug Central	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	None
		7216	2342	117	None	1	4	Guinea pig	8.2	pKd	=	8.2	Binding	NoneNone	Drug Central	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	None
		CHEMBL998	2342	117	None	1	4	Guinea pig	8.2	pKd	=	8.2	Binding	NoneNone	Drug Central	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	None
		DB00455	2342	117	None	1	4	Guinea pig	8.2	pKd	=	8.2	Binding	NoneNone	Drug Central	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	None
		2600	3779	74	None	-3	13	Guinea pig	8.1	pKd	=	8.1	Binding	Dissociation constant was determined against H1 receptor of guinea pig lung membranes using radioligand binding assays.Dissociation constant was determined against H1 receptor of guinea pig lung membranes using radioligand binding assays.	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		2608	3779	74	None	-3	13	Guinea pig	8.1	pKd	=	8.1	Binding	Dissociation constant was determined against H1 receptor of guinea pig lung membranes using radioligand binding assays.Dissociation constant was determined against H1 receptor of guinea pig lung membranes using radioligand binding assays.	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		5405	3779	74	None	-3	13	Guinea pig	8.1	pKd	=	8.1	Binding	Dissociation constant was determined against H1 receptor of guinea pig lung membranes using radioligand binding assays.Dissociation constant was determined against H1 receptor of guinea pig lung membranes using radioligand binding assays.	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		CHEMBL17157	3779	74	None	-3	13	Guinea pig	8.1	pKd	=	8.1	Binding	Dissociation constant was determined against H1 receptor of guinea pig lung membranes using radioligand binding assays.Dissociation constant was determined against H1 receptor of guinea pig lung membranes using radioligand binding assays.	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		DB00342	3779	74	None	-3	13	Guinea pig	8.1	pKd	=	8.1	Binding	Dissociation constant was determined against H1 receptor of guinea pig lung membranes using radioligand binding assays.Dissociation constant was determined against H1 receptor of guinea pig lung membranes using radioligand binding assays.	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		1971	2866	38	None	-1	30	Human	8.1	pKd	=	8.1	Binding	NoneNone	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		2404	2866	38	None	-1	30	Human	8.1	pKd	=	8.1	Binding	NoneNone	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		4543	2866	38	None	-1	30	Human	8.1	pKd	=	8.1	Binding	NoneNone	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		CHEMBL445	2866	38	None	-1	30	Human	8.1	pKd	=	8.1	Binding	NoneNone	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		DB00540	2866	38	None	-1	30	Human	8.1	pKd	=	8.1	Binding	NoneNone	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		11291	98796	25	None	4	2	Guinea pig	8.1	pKd	=	8.1	Binding	Potency against histamine H1 receptor on guinea pig ileumPotency against histamine H1 receptor on guinea pig ileum	Drug Central	261	1	0	1	3.9	CN1CCC2=C(C1)C(c1ccccc1)c1ccccc12	None
		CHEMBL278398	98796	25	None	4	2	Guinea pig	8.1	pKd	=	8.1	Binding	Potency against histamine H1 receptor on guinea pig ileumPotency against histamine H1 receptor on guinea pig ileum	Drug Central	261	1	0	1	3.9	CN1CCC2=C(C1)C(c1ccccc1)c1ccccc12	None
		277	1301	62	None	2	50	Guinea pig	8.1	pKd	=	8.1	Binding	Potency against histamine H1 receptor on guinea pig ileumPotency against histamine H1 receptor on guinea pig ileum	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	1301	62	None	2	50	Guinea pig	8.1	pKd	=	8.1	Binding	Potency against histamine H1 receptor on guinea pig ileumPotency against histamine H1 receptor on guinea pig ileum	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	1301	62	None	2	50	Guinea pig	8.1	pKd	=	8.1	Binding	Potency against histamine H1 receptor on guinea pig ileumPotency against histamine H1 receptor on guinea pig ileum	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	1301	62	None	2	50	Guinea pig	8.1	pKd	=	8.1	Binding	Potency against histamine H1 receptor on guinea pig ileumPotency against histamine H1 receptor on guinea pig ileum	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	1301	62	None	2	50	Guinea pig	8.1	pKd	=	8.1	Binding	Potency against histamine H1 receptor on guinea pig ileumPotency against histamine H1 receptor on guinea pig ileum	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		1227	2489	43	None	2	12	Guinea pig	8.0	pKd	=	8.0	Binding	Antagonist activity at histamine H1 receptor in Cavia porcellus (guinea pig) ileum assessed as inhibition of electrically-induced contractionAntagonist activity at histamine H1 receptor in Cavia porcellus (guinea pig) ileum assessed as inhibition of electrically-induced contraction	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		2331	2489	43	None	2	12	Guinea pig	8.0	pKd	=	8.0	Binding	Antagonist activity at histamine H1 receptor in Cavia porcellus (guinea pig) ileum assessed as inhibition of electrically-induced contractionAntagonist activity at histamine H1 receptor in Cavia porcellus (guinea pig) ileum assessed as inhibition of electrically-induced contraction	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		3957	2489	43	None	2	12	Guinea pig	8.0	pKd	=	8.0	Binding	Antagonist activity at histamine H1 receptor in Cavia porcellus (guinea pig) ileum assessed as inhibition of electrically-induced contractionAntagonist activity at histamine H1 receptor in Cavia porcellus (guinea pig) ileum assessed as inhibition of electrically-induced contraction	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		4992	2489	43	None	2	12	Guinea pig	8.0	pKd	=	8.0	Binding	Antagonist activity at histamine H1 receptor in Cavia porcellus (guinea pig) ileum assessed as inhibition of electrically-induced contractionAntagonist activity at histamine H1 receptor in Cavia porcellus (guinea pig) ileum assessed as inhibition of electrically-induced contraction	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		CHEMBL511	2489	43	None	2	12	Guinea pig	8.0	pKd	=	8.0	Binding	Antagonist activity at histamine H1 receptor in Cavia porcellus (guinea pig) ileum assessed as inhibition of electrically-induced contractionAntagonist activity at histamine H1 receptor in Cavia porcellus (guinea pig) ileum assessed as inhibition of electrically-induced contraction	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		DB06691	2489	43	None	2	12	Guinea pig	8.0	pKd	=	8.0	Binding	Antagonist activity at histamine H1 receptor in Cavia porcellus (guinea pig) ileum assessed as inhibition of electrically-induced contractionAntagonist activity at histamine H1 receptor in Cavia porcellus (guinea pig) ileum assessed as inhibition of electrically-induced contraction	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		1228	3866	34	None	5	4	Guinea pig	8.0	pKd	=	8	Binding	Potency against histamine H1 receptor on guinea pig ileumPotency against histamine H1 receptor on guinea pig ileum	Drug Central	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		2763	3866	34	None	5	4	Guinea pig	8.0	pKd	=	8	Binding	Potency against histamine H1 receptor on guinea pig ileumPotency against histamine H1 receptor on guinea pig ileum	Drug Central	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		5282443	3866	34	None	5	4	Guinea pig	8.0	pKd	=	8	Binding	Potency against histamine H1 receptor on guinea pig ileumPotency against histamine H1 receptor on guinea pig ileum	Drug Central	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		CHEMBL855	3866	34	None	5	4	Guinea pig	8.0	pKd	=	8	Binding	Potency against histamine H1 receptor on guinea pig ileumPotency against histamine H1 receptor on guinea pig ileum	Drug Central	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		DB00427	3866	34	None	5	4	Guinea pig	8.0	pKd	=	8	Binding	Potency against histamine H1 receptor on guinea pig ileumPotency against histamine H1 receptor on guinea pig ileum	Drug Central	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		2762	3863	31	None	-9	2	Human	8.0	pKd	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	14667234
		5587	3863	31	None	-9	2	Human	8.0	pKd	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	14667234
		7318	3863	31	None	-9	2	Human	8.0	pKd	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	14667234
		CHEMBL1241	3863	31	None	-9	2	Human	8.0	pKd	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	14667234
		DB00792	3863	31	None	-9	2	Human	8.0	pKd	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	14667234
		1225	1471	26	None	-1	22	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	15093820
		3958	1471	26	None	-1	22	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	15093820
		667477	1471	26	None	-1	22	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	15093820
		CHEMBL860	1471	26	None	-1	22	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	15093820
		DB01142	1471	26	None	-1	22	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	15093820
		None	216151	0	3H-Histamine	8912	2	Guinea pig	10.5	pKi	=	10.5	Binding	NoneNone	PDSP KiDatabase	139	3	2	2	0.6	CC(CC1=CN=CN1)NC	None
		None	216152	0	3H-Histamine	60255	2	Guinea pig	10.5	pKi	=	10.5	Binding	NoneNone	PDSP KiDatabase	139	2	2	2	0.9	CC(C1=CN=CN1)C(C)N	None
		277	1301	62	3H-MEPYRAMINE	-2	50	Human	10.2	pKi	=	10.2	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	1301	62	3H-MEPYRAMINE	-2	50	Human	10.2	pKi	=	10.2	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	1301	62	3H-MEPYRAMINE	-2	50	Human	10.2	pKi	=	10.2	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	1301	62	3H-MEPYRAMINE	-2	50	Human	10.2	pKi	=	10.2	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	1301	62	3H-MEPYRAMINE	-2	50	Human	10.2	pKi	=	10.2	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		1225	1471	26	3H-trans-H2-PAT,(-)	-1	22	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		3958	1471	26	3H-trans-H2-PAT,(-)	-1	22	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		667477	1471	26	3H-trans-H2-PAT,(-)	-1	22	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		CHEMBL860	1471	26	3H-trans-H2-PAT,(-)	-1	22	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		DB01142	1471	26	3H-trans-H2-PAT,(-)	-1	22	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		135398745	2914	112	3H-PYRILAMINE	1	65	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-PYRILAMINE	1	65	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-PYRILAMINE	1	65	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-PYRILAMINE	1	65	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		277	1301	62	3H-MEPYRAMINE	2	50	Guinea pig	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	1301	62	3H-MEPYRAMINE	2	50	Guinea pig	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	1301	62	3H-MEPYRAMINE	2	50	Guinea pig	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	1301	62	3H-MEPYRAMINE	2	50	Guinea pig	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	1301	62	3H-MEPYRAMINE	2	50	Guinea pig	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		1225	1471	26	3H-trans-H2-PAT,(-)	1	22	Guinea pig	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		1225	1471	26	3H-MEPYRAMINE	-1	22	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		3958	1471	26	3H-trans-H2-PAT,(-)	1	22	Guinea pig	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		3958	1471	26	3H-MEPYRAMINE	-1	22	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		667477	1471	26	3H-trans-H2-PAT,(-)	1	22	Guinea pig	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		667477	1471	26	3H-MEPYRAMINE	-1	22	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		CHEMBL860	1471	26	3H-trans-H2-PAT,(-)	1	22	Guinea pig	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		CHEMBL860	1471	26	3H-MEPYRAMINE	-1	22	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		DB01142	1471	26	3H-trans-H2-PAT,(-)	1	22	Guinea pig	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		DB01142	1471	26	3H-MEPYRAMINE	-1	22	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		46780481	107531	20	3H-PYRILAMINE	-13	53	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		9903970	107531	20	3H-PYRILAMINE	-13	53	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3187365	107531	20	3H-PYRILAMINE	-13	53	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3544974	107531	20	3H-PYRILAMINE	-13	53	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		180	401	56	3H-PYRILAMINE	1	40	Guinea pig	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		200	401	56	3H-PYRILAMINE	1	40	Guinea pig	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2160	401	56	3H-PYRILAMINE	1	40	Guinea pig	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL629	401	56	3H-PYRILAMINE	1	40	Guinea pig	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		DB00321	401	56	3H-PYRILAMINE	1	40	Guinea pig	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		1225	1471	26	3H-PYRILAMINE	-1	22	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		3958	1471	26	3H-PYRILAMINE	-1	22	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		667477	1471	26	3H-PYRILAMINE	-1	22	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		CHEMBL860	1471	26	3H-PYRILAMINE	-1	22	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		DB01142	1471	26	3H-PYRILAMINE	-1	22	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		2726	919	68	3H-PYRILAMINE	-2	72	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	3H-PYRILAMINE	-2	72	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	3H-PYRILAMINE	-2	72	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	3H-PYRILAMINE	-2	72	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	3H-PYRILAMINE	-2	72	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		135398737	958	93	3H-PYRILAMINE	2	89	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-PYRILAMINE	2	89	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-PYRILAMINE	2	89	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-PYRILAMINE	2	89	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-PYRILAMINE	2	89	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		2286	3183	51	3H-MEPYRAMINE	-2	30	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		4927	3183	51	3H-MEPYRAMINE	-2	30	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		7282	3183	51	3H-MEPYRAMINE	-2	30	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		CHEMBL643	3183	51	3H-MEPYRAMINE	-2	30	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		DB01069	3183	51	3H-MEPYRAMINE	-2	30	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		1225	1471	26	3H-MEPYRAMINE	1	22	Guinea pig	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		3958	1471	26	3H-MEPYRAMINE	1	22	Guinea pig	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		667477	1471	26	3H-MEPYRAMINE	1	22	Guinea pig	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		CHEMBL860	1471	26	3H-MEPYRAMINE	1	22	Guinea pig	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		DB01142	1471	26	3H-MEPYRAMINE	1	22	Guinea pig	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		135	2532	43	3H-MEPYRAMINE	-1	58	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-MEPYRAMINE	-1	58	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-MEPYRAMINE	-1	58	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-MEPYRAMINE	-1	58	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-MEPYRAMINE	-1	58	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1228	3866	34	3H-MEPYRAMINE	5	4	Guinea pig	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		2763	3866	34	3H-MEPYRAMINE	5	4	Guinea pig	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		5282443	3866	34	3H-MEPYRAMINE	5	4	Guinea pig	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		CHEMBL855	3866	34	3H-MEPYRAMINE	5	4	Guinea pig	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		DB00427	3866	34	3H-MEPYRAMINE	5	4	Guinea pig	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		16667681	216153	0	3H-MEPYRAMINE	4	3	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	390	7	1	5	3.5	CN(C)CCCC1=CC=CC=N1.C1=CC(=CC=C1OC(=O)C=CC(=O)O)Cl	None
		1225	1471	26	3H-MEPYRAMINE	-1	22	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		3958	1471	26	3H-MEPYRAMINE	-1	22	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		667477	1471	26	3H-MEPYRAMINE	-1	22	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		CHEMBL860	1471	26	3H-MEPYRAMINE	-1	22	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		DB01142	1471	26	3H-MEPYRAMINE	-1	22	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		1816	2540	102	3H-MEPYRAMINE	3	18	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		4205	2540	102	3H-MEPYRAMINE	3	18	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		7241	2540	102	3H-MEPYRAMINE	3	18	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		CHEMBL654	2540	102	3H-MEPYRAMINE	3	18	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		DB00370	2540	102	3H-MEPYRAMINE	3	18	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		135398745	2914	112	3H-pirilamine	-1	65	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-pirilamine	-1	65	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-pirilamine	-1	65	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-pirilamine	-1	65	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		135	2532	43	3H-doxepin	-1	58	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-doxepin	-1	58	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-doxepin	-1	58	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-doxepin	-1	58	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-doxepin	-1	58	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1225	1471	26	3H-MEPYRAMINE	-1	22	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		3958	1471	26	3H-MEPYRAMINE	-1	22	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		667477	1471	26	3H-MEPYRAMINE	-1	22	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		CHEMBL860	1471	26	3H-MEPYRAMINE	-1	22	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		DB01142	1471	26	3H-MEPYRAMINE	-1	22	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		135	2532	43	3H-PYRILAMINE	-1	58	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-PYRILAMINE	-1	58	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-PYRILAMINE	-1	58	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-PYRILAMINE	-1	58	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-PYRILAMINE	-1	58	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1210	918	51	3H-PYRILAMINE	9	21	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		1213	918	51	3H-PYRILAMINE	9	21	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		2725	918	51	3H-PYRILAMINE	9	21	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		33036	918	51	3H-PYRILAMINE	9	21	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		4411	918	51	3H-PYRILAMINE	9	21	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		616	918	51	3H-PYRILAMINE	9	21	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		6976	918	51	3H-PYRILAMINE	9	21	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		716121	918	51	3H-PYRILAMINE	9	21	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL1201353	918	51	3H-PYRILAMINE	9	21	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL1554789	918	51	3H-PYRILAMINE	9	21	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL505	918	51	3H-PYRILAMINE	9	21	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		DB01114	918	51	3H-PYRILAMINE	9	21	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		DB13679	918	51	3H-PYRILAMINE	9	21	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		1228	3866	34	3H-MEPYRAMINE	-5	4	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		2763	3866	34	3H-MEPYRAMINE	-5	4	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		5282443	3866	34	3H-MEPYRAMINE	-5	4	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		CHEMBL855	3866	34	3H-MEPYRAMINE	-5	4	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		DB00427	3866	34	3H-MEPYRAMINE	-5	4	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		1225	1471	26	3H-doxepin	-1	22	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		3958	1471	26	3H-doxepin	-1	22	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		667477	1471	26	3H-doxepin	-1	22	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		CHEMBL860	1471	26	3H-doxepin	-1	22	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		DB01142	1471	26	3H-doxepin	-1	22	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		180	401	56	3H-MEPYRAMINE	-1	40	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		200	401	56	3H-MEPYRAMINE	-1	40	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2160	401	56	3H-MEPYRAMINE	-1	40	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL629	401	56	3H-MEPYRAMINE	-1	40	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		DB00321	401	56	3H-MEPYRAMINE	-1	40	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		1210	918	51	3H-MEPYRAMINE	9	21	Guinea pig	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		1213	918	51	3H-MEPYRAMINE	9	21	Guinea pig	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		2725	918	51	3H-MEPYRAMINE	9	21	Guinea pig	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		33036	918	51	3H-MEPYRAMINE	9	21	Guinea pig	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		4411	918	51	3H-MEPYRAMINE	9	21	Guinea pig	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		616	918	51	3H-MEPYRAMINE	9	21	Guinea pig	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		6976	918	51	3H-MEPYRAMINE	9	21	Guinea pig	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		716121	918	51	3H-MEPYRAMINE	9	21	Guinea pig	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL1201353	918	51	3H-MEPYRAMINE	9	21	Guinea pig	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL1554789	918	51	3H-MEPYRAMINE	9	21	Guinea pig	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL505	918	51	3H-MEPYRAMINE	9	21	Guinea pig	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		DB01114	918	51	3H-MEPYRAMINE	9	21	Guinea pig	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		DB13679	918	51	3H-MEPYRAMINE	9	21	Guinea pig	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		1225	1471	26	3H-MEPYRAMINE	1	22	Guinea pig	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		3958	1471	26	3H-MEPYRAMINE	1	22	Guinea pig	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		667477	1471	26	3H-MEPYRAMINE	1	22	Guinea pig	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		CHEMBL860	1471	26	3H-MEPYRAMINE	1	22	Guinea pig	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		DB01142	1471	26	3H-MEPYRAMINE	1	22	Guinea pig	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		1227	2489	43	3H-MEPYRAMINE	2	12	Guinea pig	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		2331	2489	43	3H-MEPYRAMINE	2	12	Guinea pig	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		3957	2489	43	3H-MEPYRAMINE	2	12	Guinea pig	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		4992	2489	43	3H-MEPYRAMINE	2	12	Guinea pig	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		CHEMBL511	2489	43	3H-MEPYRAMINE	2	12	Guinea pig	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		DB06691	2489	43	3H-MEPYRAMINE	2	12	Guinea pig	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		1816	2540	102	3H-PYRILAMINE	-3	18	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		1816	2540	102	3H-MEPYRAMINE	3	18	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		4205	2540	102	3H-PYRILAMINE	-3	18	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		4205	2540	102	3H-MEPYRAMINE	3	18	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		7241	2540	102	3H-PYRILAMINE	-3	18	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		7241	2540	102	3H-MEPYRAMINE	3	18	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		CHEMBL654	2540	102	3H-PYRILAMINE	-3	18	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		CHEMBL654	2540	102	3H-MEPYRAMINE	3	18	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		DB00370	2540	102	3H-PYRILAMINE	-3	18	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		DB00370	2540	102	3H-MEPYRAMINE	3	18	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		None	216141	0	3H-Histamine	-4	6	Guinea pig	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	125	2	2	2	0.3	CC(CC1=CN=CN1)N	None
		1227	2489	43	3H-MEPYRAMINE	-2	12	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		2331	2489	43	3H-MEPYRAMINE	-2	12	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		3957	2489	43	3H-MEPYRAMINE	-2	12	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		4992	2489	43	3H-MEPYRAMINE	-2	12	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		CHEMBL511	2489	43	3H-MEPYRAMINE	-2	12	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		DB06691	2489	43	3H-MEPYRAMINE	-2	12	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		1227	2489	43	3H-MEPYRAMINE	2	12	Guinea pig	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		2331	2489	43	3H-MEPYRAMINE	2	12	Guinea pig	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		3957	2489	43	3H-MEPYRAMINE	2	12	Guinea pig	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		4992	2489	43	3H-MEPYRAMINE	2	12	Guinea pig	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		CHEMBL511	2489	43	3H-MEPYRAMINE	2	12	Guinea pig	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		DB06691	2489	43	3H-MEPYRAMINE	2	12	Guinea pig	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		72287	61061	38	3H-doxepin	6	2	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	328	5	0	4	4.5	COc1ccc2c(c1)N(C[C@H](C)CN(C)C)c1ccccc1S2	None
		CHEMBL1764	61061	38	3H-doxepin	6	2	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	328	5	0	4	4.5	COc1ccc2c(c1)N(C[C@H](C)CN(C)C)c1ccccc1S2	None
		1228	3866	34	3H-MEPYRAMINE	5	4	Guinea pig	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		2763	3866	34	3H-MEPYRAMINE	5	4	Guinea pig	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		5282443	3866	34	3H-MEPYRAMINE	5	4	Guinea pig	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		CHEMBL855	3866	34	3H-MEPYRAMINE	5	4	Guinea pig	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		DB00427	3866	34	3H-MEPYRAMINE	5	4	Guinea pig	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		103	4153	61	3H-PYRILAMINE	-1	53	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	4153	61	3H-PYRILAMINE	-1	53	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	4153	61	3H-PYRILAMINE	-1	53	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	4153	61	3H-PYRILAMINE	-1	53	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	4153	61	3H-PYRILAMINE	-1	53	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		1816	2540	102	3H-MEPYRAMINE	3	18	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		4205	2540	102	3H-MEPYRAMINE	3	18	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		7241	2540	102	3H-MEPYRAMINE	3	18	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		CHEMBL654	2540	102	3H-MEPYRAMINE	3	18	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		DB00370	2540	102	3H-MEPYRAMINE	3	18	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		135398745	2914	112	3H-PYRILAMINE	1	65	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-PYRILAMINE	1	65	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-PYRILAMINE	1	65	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-PYRILAMINE	1	65	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		180	401	56	3H-doxepin	-1	40	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		200	401	56	3H-doxepin	-1	40	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2160	401	56	3H-doxepin	-1	40	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL629	401	56	3H-doxepin	-1	40	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		DB00321	401	56	3H-doxepin	-1	40	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		1228	3866	34	3H-trans-H2-PAT,(-)	5	4	Guinea pig	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		1228	3866	34	3H-MEPYRAMINE	-5	4	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		2763	3866	34	3H-trans-H2-PAT,(-)	5	4	Guinea pig	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		2763	3866	34	3H-MEPYRAMINE	-5	4	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		5282443	3866	34	3H-trans-H2-PAT,(-)	5	4	Guinea pig	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		5282443	3866	34	3H-MEPYRAMINE	-5	4	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		CHEMBL855	3866	34	3H-trans-H2-PAT,(-)	5	4	Guinea pig	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		CHEMBL855	3866	34	3H-MEPYRAMINE	-5	4	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		DB00427	3866	34	3H-trans-H2-PAT,(-)	5	4	Guinea pig	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		DB00427	3866	34	3H-MEPYRAMINE	-5	4	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		90475904	216022	0	3H-trans-H2-PAT,(-)	6	6	Guinea pig	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(C)CCC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2	None
		1225	1471	26	3H-MEPYRAMINE	-2	22	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		3958	1471	26	3H-MEPYRAMINE	-2	22	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		667477	1471	26	3H-MEPYRAMINE	-2	22	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		CHEMBL860	1471	26	3H-MEPYRAMINE	-2	22	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		DB01142	1471	26	3H-MEPYRAMINE	-2	22	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		3246155	215962	0	3H-MEPYRAMINE	-3	16	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	307	4	0	2	4.4	CN1C2CCC1CC(C2)OC(C3=CC=CC=C3)C4=CC=CC=C4	None
		1227	2489	43	3H-trans-H2-PAT,(-)	2	12	Guinea pig	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		1227	2489	43	3H-MEPYRAMINE	-2	12	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		2331	2489	43	3H-trans-H2-PAT,(-)	2	12	Guinea pig	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		2331	2489	43	3H-MEPYRAMINE	-2	12	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		3957	2489	43	3H-trans-H2-PAT,(-)	2	12	Guinea pig	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		3957	2489	43	3H-MEPYRAMINE	-2	12	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		4992	2489	43	3H-trans-H2-PAT,(-)	2	12	Guinea pig	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		4992	2489	43	3H-MEPYRAMINE	-2	12	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		CHEMBL511	2489	43	3H-trans-H2-PAT,(-)	2	12	Guinea pig	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		CHEMBL511	2489	43	3H-MEPYRAMINE	-2	12	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		DB06691	2489	43	3H-trans-H2-PAT,(-)	2	12	Guinea pig	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		DB06691	2489	43	3H-MEPYRAMINE	-2	12	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		4011	82408	49	3H-doxepin	6	24	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	None
		CHEMBL21731	82408	49	3H-doxepin	6	24	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	None
		2247	505	81	3H-PYRILAMINE	3	42	Guinea pig	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		2247	505	81	3H-PYRILAMINE	-4	42	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		249	505	81	3H-PYRILAMINE	3	42	Guinea pig	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		249	505	81	3H-PYRILAMINE	-4	42	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		2603	505	81	3H-PYRILAMINE	3	42	Guinea pig	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		2603	505	81	3H-PYRILAMINE	-4	42	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		CHEMBL296419	505	81	3H-PYRILAMINE	3	42	Guinea pig	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		CHEMBL296419	505	81	3H-PYRILAMINE	-4	42	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		DB00637	505	81	3H-PYRILAMINE	3	42	Guinea pig	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		DB00637	505	81	3H-PYRILAMINE	-4	42	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		565544	109743	11	3H-Histamine	354	2	Guinea pig	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	125	2	2	2	0.5	CC(CN)c1cnc[nH]1	None
		CHEMBL322988	109743	11	3H-Histamine	354	2	Guinea pig	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	125	2	2	2	0.5	CC(CN)c1cnc[nH]1	None
		5281878	1660	35	3H-MEPYRAMINE	-1	17	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281881	1660	35	3H-MEPYRAMINE	-1	17	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		948	1660	35	3H-MEPYRAMINE	-1	17	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		968	1660	35	3H-MEPYRAMINE	-1	17	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL42055	1660	35	3H-MEPYRAMINE	-1	17	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL54661	1660	35	3H-MEPYRAMINE	-1	17	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00875	1660	35	3H-MEPYRAMINE	-1	17	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		46780481	107531	20	3H-PYRILAMINE	-5	53	Guinea pig	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		9903970	107531	20	3H-PYRILAMINE	-5	53	Guinea pig	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3187365	107531	20	3H-PYRILAMINE	-5	53	Guinea pig	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3544974	107531	20	3H-PYRILAMINE	-5	53	Guinea pig	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		1228	3866	34	3H-MEPYRAMINE	5	4	Guinea pig	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		2763	3866	34	3H-MEPYRAMINE	5	4	Guinea pig	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		5282443	3866	34	3H-MEPYRAMINE	5	4	Guinea pig	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		CHEMBL855	3866	34	3H-MEPYRAMINE	5	4	Guinea pig	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		DB00427	3866	34	3H-MEPYRAMINE	5	4	Guinea pig	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		180	401	56	3H-PYRILAMINE	-1	40	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		200	401	56	3H-PYRILAMINE	-1	40	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2160	401	56	3H-PYRILAMINE	-1	40	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL629	401	56	3H-PYRILAMINE	-1	40	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		DB00321	401	56	3H-PYRILAMINE	-1	40	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		1400	1957	70	3H-MEPYRAMINE	2	3	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		3658	1957	70	3H-MEPYRAMINE	2	3	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		7199	1957	70	3H-MEPYRAMINE	2	3	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		91513	1957	70	3H-MEPYRAMINE	2	3	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		CHEMBL896	1957	70	3H-MEPYRAMINE	2	3	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		DB00557	1957	70	3H-MEPYRAMINE	2	3	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		1227	2489	43	3H-MEPYRAMINE	-2	12	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		2331	2489	43	3H-MEPYRAMINE	-2	12	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		3957	2489	43	3H-MEPYRAMINE	-2	12	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		4992	2489	43	3H-MEPYRAMINE	-2	12	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		CHEMBL511	2489	43	3H-MEPYRAMINE	-2	12	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		DB06691	2489	43	3H-MEPYRAMINE	-2	12	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		135	2532	43	3H-MEPYRAMINE	1	58	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-MEPYRAMINE	1	58	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-MEPYRAMINE	1	58	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-MEPYRAMINE	1	58	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-MEPYRAMINE	1	58	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1228	3866	34	3H-MEPYRAMINE	-5	4	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		2763	3866	34	3H-MEPYRAMINE	-5	4	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		5282443	3866	34	3H-MEPYRAMINE	-5	4	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		CHEMBL855	3866	34	3H-MEPYRAMINE	-5	4	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		DB00427	3866	34	3H-MEPYRAMINE	-5	4	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		1227	2489	43	3H-trans-H2-PAT,(-)	-2	12	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		2331	2489	43	3H-trans-H2-PAT,(-)	-2	12	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		3957	2489	43	3H-trans-H2-PAT,(-)	-2	12	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		4992	2489	43	3H-trans-H2-PAT,(-)	-2	12	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		CHEMBL511	2489	43	3H-trans-H2-PAT,(-)	-2	12	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		DB06691	2489	43	3H-trans-H2-PAT,(-)	-2	12	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		180	401	56	3H-MEPYRAMINE	-1	40	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		200	401	56	3H-MEPYRAMINE	-1	40	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2160	401	56	3H-MEPYRAMINE	-1	40	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL629	401	56	3H-MEPYRAMINE	-1	40	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		DB00321	401	56	3H-MEPYRAMINE	-1	40	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		135398737	958	93	3H-PYRILAMINE	2	89	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-PYRILAMINE	2	89	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-PYRILAMINE	2	89	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-PYRILAMINE	2	89	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-PYRILAMINE	2	89	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		3246155	215962	0	3H-doxepin	-3	16	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	307	4	0	2	4.4	CN1C2CCC1CC(C2)OC(C3=CC=CC=C3)C4=CC=CC=C4	None
		1228	3866	34	3H-trans-H2-PAT,(-)	-5	4	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		2763	3866	34	3H-trans-H2-PAT,(-)	-5	4	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		5282443	3866	34	3H-trans-H2-PAT,(-)	-5	4	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		CHEMBL855	3866	34	3H-trans-H2-PAT,(-)	-5	4	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		DB00427	3866	34	3H-trans-H2-PAT,(-)	-5	4	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		180	401	56	UNDEFINED	-1	40	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		200	401	56	UNDEFINED	-1	40	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2160	401	56	UNDEFINED	-1	40	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL629	401	56	UNDEFINED	-1	40	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		DB00321	401	56	UNDEFINED	-1	40	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		1228	3866	34	3H-MEPYRAMINE	5	4	Guinea pig	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		2763	3866	34	3H-MEPYRAMINE	5	4	Guinea pig	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		5282443	3866	34	3H-MEPYRAMINE	5	4	Guinea pig	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		CHEMBL855	3866	34	3H-MEPYRAMINE	5	4	Guinea pig	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		DB00427	3866	34	3H-MEPYRAMINE	5	4	Guinea pig	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		16667681	216153	0	3H-MEPYRAMINE	4	3	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	390	7	1	5	3.5	CN(C)CCCC1=CC=CC=N1.C1=CC(=CC=C1OC(=O)C=CC(=O)O)Cl	None
		1227	2489	43	3H-MEPYRAMINE	-2	12	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		2331	2489	43	3H-MEPYRAMINE	-2	12	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		3957	2489	43	3H-MEPYRAMINE	-2	12	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		4992	2489	43	3H-MEPYRAMINE	-2	12	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		CHEMBL511	2489	43	3H-MEPYRAMINE	-2	12	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		DB06691	2489	43	3H-MEPYRAMINE	-2	12	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		135398737	958	93	3H-PYRILAMINE	2	89	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		135398737	958	93	3H-doxepin	2	89	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-PYRILAMINE	2	89	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-doxepin	2	89	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-PYRILAMINE	2	89	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-doxepin	2	89	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-PYRILAMINE	2	89	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-doxepin	2	89	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-PYRILAMINE	2	89	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-doxepin	2	89	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		135398745	2914	112	3H-PYRILAMINE	1	65	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-PYRILAMINE	1	65	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-PYRILAMINE	1	65	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-PYRILAMINE	1	65	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		135398737	958	93	3H-MEPYRAMINE	-2	89	Guinea pig	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-MEPYRAMINE	-2	89	Guinea pig	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-MEPYRAMINE	-2	89	Guinea pig	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-MEPYRAMINE	-2	89	Guinea pig	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-MEPYRAMINE	-2	89	Guinea pig	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		1227	2489	43	3H-MEPYRAMINE	2	12	Guinea pig	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		2331	2489	43	3H-MEPYRAMINE	2	12	Guinea pig	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		3957	2489	43	3H-MEPYRAMINE	2	12	Guinea pig	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		4992	2489	43	3H-MEPYRAMINE	2	12	Guinea pig	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		CHEMBL511	2489	43	3H-MEPYRAMINE	2	12	Guinea pig	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		DB06691	2489	43	3H-MEPYRAMINE	2	12	Guinea pig	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		2749	344	40	3H-MEPYRAMINE	-1	2	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	None
		5574	344	40	3H-MEPYRAMINE	-1	2	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	None
		7237	344	40	3H-MEPYRAMINE	-1	2	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	None
		CHEMBL829	344	40	3H-MEPYRAMINE	-1	2	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	None
		DB01246	344	40	3H-MEPYRAMINE	-1	2	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	None
		3246155	215962	0	3H-MEPYRAMINE	-5	16	Guinea pig	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	307	4	0	2	4.4	CN1C2CCC1CC(C2)OC(C3=CC=CC=C3)C4=CC=CC=C4	None
		5584	203211	44	3H-doxepin	-	1	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	294	4	0	2	4.1	CC(CN(C)C)CN1c2ccccc2CCc2ccccc21	None
		CHEMBL644	203211	44	3H-doxepin	-	1	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	294	4	0	2	4.1	CC(CN(C)C)CN1c2ccccc2CCc2ccccc21	None
		None	216175	0	3H-MEPYRAMINE	-	1	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	296	3	0	3	4.4	C1CCN(C1)CCN2C3=CC=CC=C3SC4=CC=CC=C42	None
		1228	3866	34	3H-MEPYRAMINE	-5	4	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		2763	3866	34	3H-MEPYRAMINE	-5	4	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		5282443	3866	34	3H-MEPYRAMINE	-5	4	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		CHEMBL855	3866	34	3H-MEPYRAMINE	-5	4	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		DB00427	3866	34	3H-MEPYRAMINE	-5	4	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		135398737	958	93	3H-trans-H2-PAT,(-)	2	89	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-trans-H2-PAT,(-)	2	89	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-trans-H2-PAT,(-)	2	89	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-trans-H2-PAT,(-)	2	89	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-trans-H2-PAT,(-)	2	89	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		180	401	56	3H-MEPYRAMINE	1	40	Guinea pig	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		200	401	56	3H-MEPYRAMINE	1	40	Guinea pig	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2160	401	56	3H-MEPYRAMINE	1	40	Guinea pig	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL629	401	56	3H-MEPYRAMINE	1	40	Guinea pig	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		DB00321	401	56	3H-MEPYRAMINE	1	40	Guinea pig	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		1816	2540	102	3H-PYRILAMINE	-3	18	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		4205	2540	102	3H-PYRILAMINE	-3	18	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		7241	2540	102	3H-PYRILAMINE	-3	18	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		CHEMBL654	2540	102	3H-PYRILAMINE	-3	18	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		DB00370	2540	102	3H-PYRILAMINE	-3	18	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		135398737	958	93	3H-MEPYRAMINE	2	89	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-MEPYRAMINE	2	89	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-MEPYRAMINE	2	89	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-MEPYRAMINE	2	89	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-MEPYRAMINE	2	89	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		4011	82408	49	UNDEFINED	6	24	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	None
		CHEMBL21731	82408	49	UNDEFINED	6	24	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	None
		135	2532	43	3H-PYRILAMINE	-1	58	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-PYRILAMINE	-1	58	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-PYRILAMINE	-1	58	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-PYRILAMINE	-1	58	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-PYRILAMINE	-1	58	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		135	2532	43	3H-MEPYRAMINE	1	58	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-MEPYRAMINE	1	58	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-MEPYRAMINE	1	58	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-MEPYRAMINE	1	58	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-MEPYRAMINE	1	58	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1524	2181	96	3H-MEPYRAMINE	-2	52	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	3H-MEPYRAMINE	-2	52	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	3H-MEPYRAMINE	-2	52	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	3H-MEPYRAMINE	-2	52	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	3H-MEPYRAMINE	-2	52	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	3H-MEPYRAMINE	-2	52	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		135398737	958	93	3H-PYRILAMINE	2	89	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		135398737	958	93	UNDEFINED	2	89	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-PYRILAMINE	2	89	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	UNDEFINED	2	89	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-PYRILAMINE	2	89	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	UNDEFINED	2	89	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-PYRILAMINE	2	89	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	UNDEFINED	2	89	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-PYRILAMINE	2	89	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	UNDEFINED	2	89	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		1712	2492	43	3H-doxepin	1	22	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		4078	2492	43	3H-doxepin	1	22	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		7227	2492	43	3H-doxepin	1	22	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		CHEMBL1088	2492	43	3H-doxepin	1	22	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		DB00933	2492	43	3H-doxepin	1	22	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		1712	2492	43	UNDEFINED	1	22	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		4078	2492	43	UNDEFINED	1	22	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		7227	2492	43	UNDEFINED	1	22	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		CHEMBL1088	2492	43	UNDEFINED	1	22	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		DB00933	2492	43	UNDEFINED	1	22	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		135398737	958	93	3H-PYRILAMINE	2	89	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-PYRILAMINE	2	89	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-PYRILAMINE	2	89	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-PYRILAMINE	2	89	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-PYRILAMINE	2	89	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		135398737	958	93	3H-MEPYRAMINE	2	89	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-MEPYRAMINE	2	89	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-MEPYRAMINE	2	89	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-MEPYRAMINE	2	89	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-MEPYRAMINE	2	89	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		90475904	216022	0	3H-MEPYRAMINE	6	6	Guinea pig	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(C)CCC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2	None
		1222	881	0	3H-MEPYRAMINE	-1	2	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		2678	881	0	3H-MEPYRAMINE	-1	2	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		581	881	0	3H-MEPYRAMINE	-1	2	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		CHEMBL1000	881	0	3H-MEPYRAMINE	-1	2	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		DB00341	881	0	3H-MEPYRAMINE	-1	2	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		1170	1633	75	3H-MEPYRAMINE	-	1	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	None
		3348	1633	75	3H-MEPYRAMINE	-	1	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	None
		4819	1633	75	3H-MEPYRAMINE	-	1	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	None
		74685737	1633	75	3H-MEPYRAMINE	-	1	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	None
		CHEMBL914	1633	75	3H-MEPYRAMINE	-	1	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	None
		DB00950	1633	75	3H-MEPYRAMINE	-	1	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	None
		1971	2866	38	3H-MEPYRAMINE	-1	30	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		2404	2866	38	3H-MEPYRAMINE	-1	30	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		4543	2866	38	3H-MEPYRAMINE	-1	30	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		CHEMBL445	2866	38	3H-MEPYRAMINE	-1	30	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		DB00540	2866	38	3H-MEPYRAMINE	-1	30	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		115237	55585	119	3H-PYRILAMINE	-42	54	Guinea pig	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		CHEMBL1621	55585	119	3H-PYRILAMINE	-42	54	Guinea pig	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		None	216919	0	UNDEFINED	-	1	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	311	4	1	4	2.7	C1COC2=C1C=CC=C2OC(C3CNCCO3)C4=CC=CC=C4	None
		None	216920	0	UNDEFINED	-	1	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	305	4	1	3	3.1	C1COC(CN1)C(C2=CC=CC=C2)OC3=C(C(=CC=C3)F)F	None
		None	216921	0	UNDEFINED	-	1	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	301	4	1	3	3.2	CC1=C(C=CC(=C1)F)OC(C2CNCCO2)C3=CC=CC=C3	None
		None	216922	0	UNDEFINED	-	1	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	3.6	C1COC(CN1)C(C2=CC=CC=C2)OC3=C(C=C(C=C3)F)Cl	None
		None	216923	0	UNDEFINED	-	1	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	317	5	1	4	2.9	COC1=C(C=CC(=C1)F)OC(C2CNCCO2)C3=CC=CC=C3	None
		277	1301	62	None	-2	50	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	1301	62	None	-2	50	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	1301	62	None	-2	50	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	1301	62	None	-2	50	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	1301	62	None	-2	50	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		3246155	215962	0	3H-MEPYRAMINE	-46	16	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	307	4	0	2	4.4	CN1C2CCC1CC(C2)OC(C3=CC=CC=C3)C4=CC=CC=C4	None
		1204	1932	119	3H-Histamine	-46	24	Guinea pig	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	3H-Histamine	-46	24	Guinea pig	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	3H-Histamine	-46	24	Guinea pig	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	3H-Histamine	-46	24	Guinea pig	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	3H-Histamine	-46	24	Guinea pig	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	3H-Histamine	-46	24	Guinea pig	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		21722	17992	31	3H-MEPYRAMINE	-1	6	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	None
		CHEMBL126224	17992	31	3H-MEPYRAMINE	-1	6	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	None
		1353	1911	93	3H-MEPYRAMINE	-602	83	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-MEPYRAMINE	-602	83	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-MEPYRAMINE	-602	83	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-MEPYRAMINE	-602	83	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-MEPYRAMINE	-602	83	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		46222048	8984	0	UNDEFINED	-4365	13	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	260	4	1	2	4.0	CC(C)(C)c1ccc(SCCc2c[nH]cn2)cc1	None
		CHEMBL1098230	8984	0	UNDEFINED	-4365	13	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	260	4	1	2	4.0	CC(C)(C)c1ccc(SCCc2c[nH]cn2)cc1	None
		18922713	98498	0	3H-PYRILAMINE	-12882	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	298	6	1	2	4.0	CCCN(CCC)C1Cc2c[nH]c3ccc(C(C)=O)c(c23)C1	None
		CHEMBL276031	98498	0	3H-PYRILAMINE	-12882	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	298	6	1	2	4.0	CCCN(CCC)C1Cc2c[nH]c3ccc(C(C)=O)c(c23)C1	None
		54841	203127	52	3H-PYRILAMINE	-2	27	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	None
		CHEMBL641	203127	52	3H-PYRILAMINE	-2	27	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	None
		3947	206395	53	3H-MEPYRAMINE	-147	16	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	None
		CHEMBL87708	206395	53	3H-MEPYRAMINE	-147	16	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	None
		12057539	208041	42	3H-MEPYRAMINE	-676	20	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	208041	42	3H-MEPYRAMINE	-676	20	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	208041	42	3H-MEPYRAMINE	-676	20	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		179	400	115	3H-PYRILAMINE	-4365	49	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		179	400	115	3H-PYRILAMINE	-4365	49	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		2159	400	115	3H-PYRILAMINE	-4365	49	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		2159	400	115	3H-PYRILAMINE	-4365	49	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		963	400	115	3H-PYRILAMINE	-4365	49	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		963	400	115	3H-PYRILAMINE	-4365	49	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		CHEMBL243712	400	115	3H-PYRILAMINE	-4365	49	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		CHEMBL243712	400	115	3H-PYRILAMINE	-4365	49	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		DB06288	400	115	3H-PYRILAMINE	-4365	49	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		DB06288	400	115	3H-PYRILAMINE	-4365	49	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		2247	505	81	3H-Histamine	-4	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		249	505	81	3H-Histamine	-4	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		2603	505	81	3H-Histamine	-4	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		CHEMBL296419	505	81	3H-Histamine	-4	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		DB00637	505	81	3H-Histamine	-4	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		1001	620	95	3H-Histamine	-3	2	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	121	2	1	1	1.2	NCCc1ccccc1	None
		2144	620	95	3H-Histamine	-3	2	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	121	2	1	1	1.2	NCCc1ccccc1	None
		CHEMBL610	620	95	3H-Histamine	-3	2	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	121	2	1	1	1.2	NCCc1ccccc1	None
		DB04325	620	95	3H-Histamine	-3	2	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	121	2	1	1	1.2	NCCc1ccccc1	None
		31101	729	40	3H-PYRILAMINE	-14454	36	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		35	729	40	3H-PYRILAMINE	-14454	36	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		403	729	40	3H-PYRILAMINE	-14454	36	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		CHEMBL493	729	40	3H-PYRILAMINE	-14454	36	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		DB01200	729	40	3H-PYRILAMINE	-14454	36	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		2554	796	119	3H-doxepin	1	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	None
		489	796	119	3H-doxepin	1	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	None
		5339	796	119	3H-doxepin	1	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	None
		CHEMBL108	796	119	3H-doxepin	1	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	None
		DB00564	796	119	3H-doxepin	1	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	None
		1222	881	0	3H-Histamine	-1	2	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		2678	881	0	3H-Histamine	-1	2	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		581	881	0	3H-Histamine	-1	2	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		CHEMBL1000	881	0	3H-Histamine	-1	2	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		DB00341	881	0	3H-Histamine	-1	2	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		1210	918	51	3H-Histamine	-20	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		1213	918	51	3H-Histamine	-20	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		2725	918	51	3H-Histamine	-20	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		33036	918	51	3H-Histamine	-20	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		4411	918	51	3H-Histamine	-20	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		616	918	51	3H-Histamine	-20	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		6976	918	51	3H-Histamine	-20	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		716121	918	51	3H-Histamine	-20	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL1201353	918	51	3H-Histamine	-20	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL1554789	918	51	3H-Histamine	-20	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL505	918	51	3H-Histamine	-20	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		DB01114	918	51	3H-Histamine	-20	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		DB13679	918	51	3H-Histamine	-20	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		1231	937	116	3H-doxepin	-81	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	252	5	3	4	0.6	N#CNC(=NC)NCCSCc1nc[nH]c1C	None
		2756	937	116	3H-doxepin	-81	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	252	5	3	4	0.6	N#CNC(=NC)NCCSCc1nc[nH]c1C	None
		645	937	116	3H-doxepin	-81	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	252	5	3	4	0.6	N#CNC(=NC)NCCSCc1nc[nH]c1C	None
		CHEMBL30	937	116	3H-doxepin	-81	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	252	5	3	4	0.6	N#CNC(=NC)NCCSCc1nc[nH]c1C	None
		DB00501	937	116	3H-doxepin	-81	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	252	5	3	4	0.6	N#CNC(=NC)NCCSCc1nc[nH]c1C	None
		1248	1424	28	3H-MEPYRAMINE	-208	6	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	161	4	2	3	0.6	CN(CCCSC(=N)N)C	None
		3077	1424	28	3H-MEPYRAMINE	-208	6	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	161	4	2	3	0.6	CN(CCCSC(=N)N)C	None
		90045	1424	28	3H-MEPYRAMINE	-208	6	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	161	4	2	3	0.6	CN(CCCSC(=N)N)C	None
		CHEMBL12344	1424	28	3H-MEPYRAMINE	-208	6	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	161	4	2	3	0.6	CN(CCCSC(=N)N)C	None
		1224	1432	83	3H-Histamine	-2	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		3100	1432	83	3H-Histamine	-2	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		8980	1432	83	3H-Histamine	-2	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		916	1432	83	3H-Histamine	-2	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		CHEMBL657	1432	83	3H-Histamine	-2	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		DB01075	1432	83	3H-Histamine	-2	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		1170	1633	75	3H-Histamine	-	1	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	None
		3348	1633	75	3H-Histamine	-	1	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	None
		4819	1633	75	3H-Histamine	-	1	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	None
		74685737	1633	75	3H-Histamine	-	1	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	None
		CHEMBL914	1633	75	3H-Histamine	-	1	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	None
		DB00950	1633	75	3H-Histamine	-	1	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	None
		1209	1658	75	3H-PYRILAMINE	-144	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		203	1658	75	3H-PYRILAMINE	-144	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		3386	1658	75	3H-PYRILAMINE	-144	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		CHEMBL41	1658	75	3H-PYRILAMINE	-144	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		DB00472	1658	75	3H-PYRILAMINE	-144	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		119376	1841	48	3H-MEPYRAMINE	-43651	26	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	393	7	1	6	1.6	O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C	None
		247	1841	48	3H-MEPYRAMINE	-43651	26	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	393	7	1	6	1.6	O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C	None
		CHEMBL33884	1841	48	3H-MEPYRAMINE	-43651	26	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	393	7	1	6	1.6	O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C	None
		1204	1932	119	3H-MEPYRAMINE	-46	24	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1204	1932	119	3H-MEPYRAMINE	-501	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1204	1932	119	3H-doxepin	-501	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1204	1932	119	3H-trans-H2-PAT,(-)	-501	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1204	1932	119	3H-MEPYRAMINE	-309	24	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	3H-MEPYRAMINE	-46	24	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	3H-MEPYRAMINE	-501	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	3H-doxepin	-501	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	3H-trans-H2-PAT,(-)	-501	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	3H-MEPYRAMINE	-309	24	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	3H-MEPYRAMINE	-46	24	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	3H-MEPYRAMINE	-501	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	3H-doxepin	-501	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	3H-trans-H2-PAT,(-)	-501	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	3H-MEPYRAMINE	-309	24	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	3H-MEPYRAMINE	-46	24	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	3H-MEPYRAMINE	-501	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	3H-doxepin	-501	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	3H-trans-H2-PAT,(-)	-501	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	3H-MEPYRAMINE	-309	24	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	3H-MEPYRAMINE	-46	24	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	3H-MEPYRAMINE	-501	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	3H-doxepin	-501	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	3H-trans-H2-PAT,(-)	-501	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	3H-MEPYRAMINE	-309	24	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	3H-MEPYRAMINE	-46	24	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	3H-MEPYRAMINE	-501	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	3H-doxepin	-501	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	3H-trans-H2-PAT,(-)	-501	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	3H-MEPYRAMINE	-309	24	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1400	1957	70	3H-Histamine	2	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		3658	1957	70	3H-Histamine	2	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		7199	1957	70	3H-Histamine	2	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		91513	1957	70	3H-Histamine	2	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		CHEMBL896	1957	70	3H-Histamine	2	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		DB00557	1957	70	3H-Histamine	2	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		1427	2013	54	3H-Histamine	-5	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		357	2013	54	3H-Histamine	-5	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		3696	2013	54	3H-Histamine	-5	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL11	2013	54	3H-Histamine	-5	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		DB00458	2013	54	3H-Histamine	-5	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		1530	2182	50	3H-Histamine	-5	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		3827	2182	50	3H-Histamine	-5	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		7206	2182	50	3H-Histamine	-5	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		CHEMBL534	2182	50	3H-Histamine	-5	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		DB00920	2182	50	3H-Histamine	-5	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		18971832	2418	0	3H-PYRILAMINE	-1621	13	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	None
		21	2418	0	3H-PYRILAMINE	-1621	13	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	None
		CHEMBL3186179	2418	0	3H-PYRILAMINE	-1621	13	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	None
		1227	2489	43	3H-Histamine	-2	12	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		2331	2489	43	3H-Histamine	-2	12	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		3957	2489	43	3H-Histamine	-2	12	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		4992	2489	43	3H-Histamine	-2	12	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		CHEMBL511	2489	43	3H-Histamine	-2	12	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		DB06691	2489	43	3H-Histamine	-2	12	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		134	2514	24	3H-PYRILAMINE	-933	67	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		134	2514	24	3H-MEPYRAMINE	-15488	67	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	3H-PYRILAMINE	-933	67	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	3H-MEPYRAMINE	-15488	67	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	3H-PYRILAMINE	-933	67	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	3H-MEPYRAMINE	-15488	67	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	3H-PYRILAMINE	-933	67	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	3H-MEPYRAMINE	-15488	67	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	3H-PYRILAMINE	-933	67	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	3H-MEPYRAMINE	-15488	67	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1233	2515	0	3H-MEPYRAMINE	-19	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	244	5	3	3	1.0	CNC(=S)NCCSCc1nc[nH]c1C	None
		1548992	2515	0	3H-MEPYRAMINE	-19	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	244	5	3	3	1.0	CNC(=S)NCCSCc1nc[nH]c1C	None
		CHEMBL275446	2515	0	3H-MEPYRAMINE	-19	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	244	5	3	3	1.0	CNC(=S)NCCSCc1nc[nH]c1C	None
		DB08805	2515	0	3H-MEPYRAMINE	-19	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	244	5	3	3	1.0	CNC(=S)NCCSCc1nc[nH]c1C	None
		1782	2518	84	3H-MEPYRAMINE	-676	22	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		241	2518	84	3H-MEPYRAMINE	-676	22	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		4168	2518	84	3H-MEPYRAMINE	-676	22	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		CHEMBL86	2518	84	3H-MEPYRAMINE	-676	22	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		DB01233	2518	84	3H-MEPYRAMINE	-676	22	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		135	2532	43	3H-Histamine	-1	58	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-Histamine	-1	58	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-Histamine	-1	58	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-Histamine	-1	58	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-Histamine	-1	58	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1830	2590	44	3H-doxepin	-125	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		1830	2590	44	UNDEFINED	-125	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		207	2590	44	3H-doxepin	-125	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		207	2590	44	UNDEFINED	-125	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		23897	2590	44	3H-doxepin	-125	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		23897	2590	44	UNDEFINED	-125	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		CHEMBL460	2590	44	3H-doxepin	-125	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		CHEMBL460	2590	44	UNDEFINED	-125	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		DB01618	2590	44	3H-doxepin	-125	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		DB01618	2590	44	UNDEFINED	-125	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		1890	2759	49	3H-PYRILAMINE	-44	16	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
		4449	2759	49	3H-PYRILAMINE	-44	16	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
		7247	2759	49	3H-PYRILAMINE	-44	16	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
		CHEMBL623	2759	49	3H-PYRILAMINE	-44	16	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
		DB01149	2759	49	3H-PYRILAMINE	-44	16	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
		15897	2862	0	3H-PYRILAMINE	-354	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		215	2862	0	3H-PYRILAMINE	-354	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		CHEMBL1979333	2862	0	3H-PYRILAMINE	-354	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		208	2863	0	3H-PYRILAMINE	-109	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		4541	2863	0	3H-PYRILAMINE	-109	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		CHEMBL1494	2863	0	3H-PYRILAMINE	-109	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		2142	3096	58	3H-MEPYRAMINE	-7585	36	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4920903	3096	58	3H-MEPYRAMINE	-7585	36	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		502	3096	58	3H-MEPYRAMINE	-7585	36	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		5775	3096	58	3H-MEPYRAMINE	-7585	36	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		CHEMBL597	3096	58	3H-MEPYRAMINE	-7585	36	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		DB00692	3096	58	3H-MEPYRAMINE	-7585	36	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		2202	3132	96	3H-PYRILAMINE	-316	21	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		4850	3132	96	3H-PYRILAMINE	-316	21	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		49	3132	96	3H-PYRILAMINE	-316	21	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		CHEMBL1371770	3132	96	3H-PYRILAMINE	-316	21	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		DB12478	3132	96	3H-PYRILAMINE	-316	21	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		119570	3159	96	3H-PYRILAMINE	-7585	40	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		119570	3159	96	3H-PYRILAMINE	-162	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		2233	3159	96	3H-PYRILAMINE	-7585	40	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		2233	3159	96	3H-PYRILAMINE	-162	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		953	3159	96	3H-PYRILAMINE	-7585	40	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		953	3159	96	3H-PYRILAMINE	-162	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		CHEMBL301265	3159	96	3H-PYRILAMINE	-7585	40	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		CHEMBL301265	3159	96	3H-PYRILAMINE	-162	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		DB00413	3159	96	3H-PYRILAMINE	-7585	40	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		DB00413	3159	96	3H-PYRILAMINE	-162	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		2286	3183	51	3H-Histamine	-2	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		4927	3183	51	3H-Histamine	-2	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		7282	3183	51	3H-Histamine	-2	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		CHEMBL643	3183	51	3H-Histamine	-2	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		DB01069	3183	51	3H-Histamine	-2	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		243	3202	91	3H-PYRILAMINE	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		3052762	3202	91	3H-PYRILAMINE	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		3502	3202	91	3H-PYRILAMINE	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		CHEMBL117287	3202	91	3H-PYRILAMINE	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		DB06480	3202	91	3H-PYRILAMINE	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		1234	3291	68	3H-MEPYRAMINE	-162	6	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	10	2	7	1.5	CN/C(=C\[N+](=O)[O-])/NCCSCc1ccc(o1)CN(C)C	None
		1234	3291	68	3H-doxepin	-162	6	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	10	2	7	1.5	CN/C(=C\[N+](=O)[O-])/NCCSCc1ccc(o1)CN(C)C	None
		3001055	3291	68	3H-MEPYRAMINE	-162	6	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	10	2	7	1.5	CN/C(=C\[N+](=O)[O-])/NCCSCc1ccc(o1)CN(C)C	None
		3001055	3291	68	3H-doxepin	-162	6	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	10	2	7	1.5	CN/C(=C\[N+](=O)[O-])/NCCSCc1ccc(o1)CN(C)C	None
		CHEMBL512	3291	68	3H-MEPYRAMINE	-162	6	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	10	2	7	1.5	CN/C(=C\[N+](=O)[O-])/NCCSCc1ccc(o1)CN(C)C	None
		CHEMBL512	3291	68	3H-doxepin	-162	6	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	10	2	7	1.5	CN/C(=C\[N+](=O)[O-])/NCCSCc1ccc(o1)CN(C)C	None
		DB00863	3291	68	3H-MEPYRAMINE	-162	6	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	10	2	7	1.5	CN/C(=C\[N+](=O)[O-])/NCCSCc1ccc(o1)CN(C)C	None
		DB00863	3291	68	3H-doxepin	-162	6	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	10	2	7	1.5	CN/C(=C\[N+](=O)[O-])/NCCSCc1ccc(o1)CN(C)C	None
		128563	3464	33	3H-PYRILAMINE	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
		1666	3464	33	3H-PYRILAMINE	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
		CHEMBL445332	3464	33	3H-PYRILAMINE	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
		DB12327	3464	33	3H-PYRILAMINE	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
		221	3491	71	UNDEFINED	-478	14	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
		3277600	3491	71	UNDEFINED	-478	14	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
		CHEMBL323356	3491	71	UNDEFINED	-478	14	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
		189	3492	39	3H-MEPYRAMINE	-4168	17	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
		5163	3492	39	3H-MEPYRAMINE	-4168	17	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
		CHEMBL297784	3492	39	3H-MEPYRAMINE	-4168	17	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
		6917970	3691	61	3H-PYRILAMINE	-2290	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
		8370	3691	61	3H-PYRILAMINE	-2290	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
		CHEMBL487387	3691	61	3H-PYRILAMINE	-2290	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
		1577	3703	110	3H-MEPYRAMINE	-549	21	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		2537	3703	110	3H-MEPYRAMINE	-549	21	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		5355	3703	110	3H-MEPYRAMINE	-549	21	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		5501	3703	110	3H-MEPYRAMINE	-549	21	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		643497	3703	110	3H-MEPYRAMINE	-549	21	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		688272	3703	110	3H-MEPYRAMINE	-549	21	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		958	3703	110	3H-MEPYRAMINE	-549	21	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		960	3703	110	3H-MEPYRAMINE	-549	21	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL196677	3703	110	3H-MEPYRAMINE	-549	21	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL26	3703	110	3H-MEPYRAMINE	-549	21	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL267044	3703	110	3H-MEPYRAMINE	-549	21	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		DB00391	3703	110	3H-MEPYRAMINE	-549	21	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		DB16021	3703	110	3H-MEPYRAMINE	-549	21	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		1267	3804	49	3H-MEPYRAMINE	-4168	26	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		1267	3804	49	3H-MEPYRAMINE	-4168	26	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		3035905	3804	49	3H-MEPYRAMINE	-4168	26	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		3035905	3804	49	3H-MEPYRAMINE	-4168	26	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		CHEMBL260374	3804	49	3H-MEPYRAMINE	-4168	26	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		CHEMBL260374	3804	49	3H-MEPYRAMINE	-4168	26	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		1235	3823	36	3H-doxepin	-316	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	312	6	4	6	-0.1	N#CNC(=NC)NCCSCc1csc(n1)N=C(N)N	None
		3959	3823	36	3H-doxepin	-316	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	312	6	4	6	-0.1	N#CNC(=NC)NCCSCc1csc(n1)N=C(N)N	None
		50287	3823	36	3H-doxepin	-316	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	312	6	4	6	-0.1	N#CNC(=NC)NCCSCc1csc(n1)N=C(N)N	None
		CHEMBL269646	3823	36	3H-doxepin	-316	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	312	6	4	6	-0.1	N#CNC(=NC)NCCSCc1csc(n1)N=C(N)N	None
		2762	3863	31	3H-Histamine	-9	2	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	None
		5587	3863	31	3H-Histamine	-9	2	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	None
		7318	3863	31	3H-Histamine	-9	2	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	None
		CHEMBL1241	3863	31	3H-Histamine	-9	2	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	None
		DB00792	3863	31	3H-Histamine	-9	2	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	None
		1228	3866	34	3H-Histamine	-5	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		2763	3866	34	3H-Histamine	-5	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		5282443	3866	34	3H-Histamine	-5	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		CHEMBL855	3866	34	3H-Histamine	-5	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		DB00427	3866	34	3H-Histamine	-5	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		46882224	6348	0	UNDEFINED	-354	5	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	543	10	1	9	4.7	CCOc1cc(CN2CCC(Nc3nc4cc(S(=O)(=O)CC)ccc4o3)CC2)cc(OC2CCOCC2)c1	None
		CHEMBL1082036	6348	0	UNDEFINED	-354	5	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	543	10	1	9	4.7	CCOc1cc(CN2CCC(Nc3nc4cc(S(=O)(=O)CC)ccc4o3)CC2)cc(OC2CCOCC2)c1	None
		2662	11384	131	3H-PYRILAMINE	-41	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
		CHEMBL118	11384	131	3H-PYRILAMINE	-41	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
		3032915	15495	24	3H-MEPYRAMINE	-169	6	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	212	5	3	2	1.2	C/N=C(\S)NCCCCc1c[nH]cn1	None
		CHEMBL12160	15495	24	3H-MEPYRAMINE	-169	6	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	212	5	3	2	1.2	C/N=C(\S)NCCCCc1c[nH]cn1	None
		3380	22790	34	3H-MEPYRAMINE	-	1	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	313	2	0	4	2.5	CN1C(=O)CN=C(c2ccccc2F)c2cc([N+](=O)[O-])ccc21	None
		CHEMBL13280	22790	34	3H-MEPYRAMINE	-	1	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	313	2	0	4	2.5	CN1C(=O)CN=C(c2ccccc2F)c2cc([N+](=O)[O-])ccc21	None
		10297	27112	30	3H-PYRILAMINE	-38	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	C[C@H](N)[C@H](O)c1ccccc1	None
		CHEMBL136560	27112	30	3H-PYRILAMINE	-38	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	C[C@H](N)[C@H](O)c1ccccc1	None
		156391	46800	99	3H-PYRILAMINE	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
		CHEMBL1200806	46800	99	3H-PYRILAMINE	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
		CHEMBL154	46800	99	3H-PYRILAMINE	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
		10624	70300	19	3H-PYRILAMINE	-776	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		10624	70300	19	3H-MEPYRAMINE	-776	33	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		138543650	70300	19	3H-PYRILAMINE	-776	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		138543650	70300	19	3H-MEPYRAMINE	-776	33	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		CHEMBL194378	70300	19	3H-PYRILAMINE	-776	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		CHEMBL194378	70300	19	3H-MEPYRAMINE	-776	33	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		54477	84653	36	3H-MEPYRAMINE	-70	23	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	None
		54477	84653	36	3H-PYRILAMINE	-70	23	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	None
		CHEMBL22242	84653	36	3H-MEPYRAMINE	-70	23	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	None
		CHEMBL22242	84653	36	3H-PYRILAMINE	-70	23	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	None
		2244	94233	100	3H-PYRILAMINE	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	180	2	1	3	1.3	CC(=O)Oc1ccccc1C(=O)O	None
		CHEMBL25	94233	100	3H-PYRILAMINE	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	180	2	1	3	1.3	CC(=O)Oc1ccccc1C(=O)O	None
		4528	98126	80	3H-Histamine	-7	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	238	1	1	2	2.8	CN1Cc2c(N)cccc2C(c2ccccc2)C1	None
		CHEMBL273575	98126	80	3H-Histamine	-7	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	238	1	1	2	2.8	CN1Cc2c(N)cccc2C(c2ccccc2)C1	None
		104870	98880	47	3H-PYRILAMINE	-549	21	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		5374	98880	47	3H-PYRILAMINE	-549	21	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		CHEMBL279085	98880	47	3H-PYRILAMINE	-549	21	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		3663	99967	83	3H-PYRILAMINE	-288	29	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	504	0	6	8	5.1	Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65	None
		CHEMBL286494	99967	83	3H-PYRILAMINE	-288	29	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	504	0	6	8	5.1	Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65	None
		37632	111592	28	3H-PYRILAMINE	-1	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	3	0	5	3.3	CN(C)Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2	None
		CHEMBL328250	111592	28	3H-PYRILAMINE	-1	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	3	0	5	3.3	CN(C)Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2	None
		3452843	119525	15	3H-PYRILAMINE	-1	10	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	516	6	2	4	5.5	Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1	None
		CHEMBL345686	119525	15	3H-PYRILAMINE	-1	10	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	516	6	2	4	5.5	Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1	None
		44208932	140707	7	UNDEFINED	-89125	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	475	5	1	3	6.8	Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1	None
		CHEMBL381689	140707	7	UNDEFINED	-89125	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	475	5	1	3	6.8	Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1	None
		4737	172454	27	3H-doxepin	-	1	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	226	4	2	3	1.2	CCCC(C)C1(CC)C(=O)NC(=O)NC1=O	None
		CHEMBL448	172454	27	3H-doxepin	-	1	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	226	4	2	3	1.2	CCCC(C)C1(CC)C(=O)NC(=O)NC1=O	None
		4595	176715	106	3H-MEPYRAMINE	-186	15	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	None
		CHEMBL46	176715	106	3H-MEPYRAMINE	-186	15	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	None
		43815	186920	64	3H-PYRILAMINE	-1995	25	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
		43815	186920	64	3H-PYRILAMINE	-1995	25	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
		43815	186920	64	3H-MEPYRAMINE	-1995	25	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
		CHEMBL1708	186920	64	3H-PYRILAMINE	-1995	25	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
		CHEMBL1708	186920	64	3H-PYRILAMINE	-1995	25	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
		CHEMBL1708	186920	64	3H-MEPYRAMINE	-1995	25	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
		CHEMBL490	186920	64	3H-PYRILAMINE	-1995	25	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
		CHEMBL490	186920	64	3H-PYRILAMINE	-1995	25	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
		CHEMBL490	186920	64	3H-MEPYRAMINE	-1995	25	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
		5280343	188275	124	3H-PYRILAMINE	-147	32	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
		CHEMBL1520590	188275	124	3H-PYRILAMINE	-147	32	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
		CHEMBL50	188275	124	3H-PYRILAMINE	-147	32	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
		12016890	190776	6	3H-PYRILAMINE	-16982	11	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	318	4	1	3	2.6	NC(=O)c1ccc(F)c2c1CC(N(C1CCC1)C1CCC1)CO2	None
		CHEMBL5183389	190776	6	3H-PYRILAMINE	-16982	11	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	318	4	1	3	2.6	NC(=O)c1ccc(F)c2c1CC(N(C1CCC1)C1CCC1)CO2	None
		3672	192533	136	3H-PYRILAMINE	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	206	4	1	1	3.1	CC(C)Cc1ccc(C(C)C(=O)O)cc1	None
		CHEMBL521	192533	136	3H-PYRILAMINE	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	206	4	1	1	3.1	CC(C)Cc1ccc(C(C)C(=O)O)cc1	None
		54676228	193615	112	3H-PYRILAMINE	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	2	2	5	1.6	CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O	None
		CHEMBL527	193615	112	3H-PYRILAMINE	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	2	2	5	1.6	CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O	None
		4495	196535	92	3H-PYRILAMINE	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	None
		CHEMBL56367	196535	92	3H-PYRILAMINE	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	None
		54677470	200551	115	3H-PYRILAMINE	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
		CHEMBL1256873	200551	115	3H-PYRILAMINE	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
		CHEMBL599	200551	115	3H-PYRILAMINE	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
		162265	202274	22	3H-PYRILAMINE	-239	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		4786	202274	22	3H-PYRILAMINE	-239	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		CHEMBL61006	202274	22	3H-PYRILAMINE	-239	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		5281600	203025	92	3H-PYRILAMINE	-275	33	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	538	3	6	10	5.1	O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12	None
		CHEMBL63354	203025	92	3H-PYRILAMINE	-275	33	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	538	3	6	10	5.1	O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12	None
		5656	203066	87	3H-PYRILAMINE	-79	40	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		5656	203066	87	3H-PYRILAMINE	-79	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		5656	203066	87	3H-MEPYRAMINE	-79	40	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		CHEMBL637	203066	87	3H-PYRILAMINE	-79	40	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		CHEMBL637	203066	87	3H-PYRILAMINE	-79	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		CHEMBL637	203066	87	3H-MEPYRAMINE	-79	40	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		1238	203174	24	3H-Histamine	-38	16	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
		CHEMBL64249	203174	24	3H-Histamine	-38	16	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
		1973	203483	15	3H-PYRILAMINE	-3	36	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	462	3	1	7	3.9	Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12	None
		CHEMBL1394464	203483	15	3H-PYRILAMINE	-3	36	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	462	3	1	7	3.9	Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12	None
		CHEMBL66089	203483	15	3H-PYRILAMINE	-3	36	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	462	3	1	7	3.9	Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12	None
		2118	203485	36	3H-doxepin	-24	2	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	308	1	0	4	3.6	Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2	None
		CHEMBL661	203485	36	3H-doxepin	-24	2	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	308	1	0	4	3.6	Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2	None
		3291	204000	77	3H-doxepin	-	1	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	141	1	1	2	0.4	CCC1(C)CC(=O)NC1=O	None
		CHEMBL696	204000	77	3H-doxepin	-	1	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	141	1	1	2	0.4	CCC1(C)CC(=O)NC1=O	None
		2995	204405	53	3H-Histamine	-14	23	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL1696	204405	53	3H-Histamine	-14	23	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL72	204405	53	3H-Histamine	-14	23	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		3821	204718	17	3H-PYRILAMINE	-1	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	237	2	1	2	2.9	CNC1(c2ccccc2Cl)CCCCC1=O	None
		CHEMBL742	204718	17	3H-PYRILAMINE	-1	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	237	2	1	2	2.9	CNC1(c2ccccc2Cl)CCCCC1=O	None
		4054	205501	72	3H-PYRILAMINE	-1	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
		CHEMBL1699	205501	72	3H-PYRILAMINE	-1	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
		CHEMBL807	205501	72	3H-PYRILAMINE	-1	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
		68617	205527	62	3H-PYRILAMINE	-1023	26	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		68617	205527	62	3H-MEPYRAMINE	-1445	26	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		CHEMBL1709	205527	62	3H-PYRILAMINE	-1023	26	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		CHEMBL1709	205527	62	3H-MEPYRAMINE	-1445	26	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		CHEMBL809	205527	62	3H-PYRILAMINE	-1023	26	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		CHEMBL809	205527	62	3H-MEPYRAMINE	-1445	26	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		5324346	205582	59	3H-PYRILAMINE	-1	10	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	318	9	1	4	3.2	COCCCC/C(=N\OCCN)c1ccc(C(F)(F)F)cc1	None
		5324346	205582	59	3H-MEPYRAMINE	-1	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	318	9	1	4	3.2	COCCCC/C(=N\OCCN)c1ccc(C(F)(F)F)cc1	None
		CHEMBL1409	205582	59	3H-PYRILAMINE	-1	10	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	318	9	1	4	3.2	COCCCC/C(=N\OCCN)c1ccc(C(F)(F)F)cc1	None
		CHEMBL1409	205582	59	3H-MEPYRAMINE	-1	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	318	9	1	4	3.2	COCCCC/C(=N\OCCN)c1ccc(C(F)(F)F)cc1	None
		CHEMBL814	205582	59	3H-PYRILAMINE	-1	10	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	318	9	1	4	3.2	COCCCC/C(=N\OCCN)c1ccc(C(F)(F)F)cc1	None
		CHEMBL814	205582	59	3H-MEPYRAMINE	-1	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	318	9	1	4	3.2	COCCCC/C(=N\OCCN)c1ccc(C(F)(F)F)cc1	None
		119607	206203	113	3H-PYRILAMINE	-97	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	1	4	3.0	Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1	None
		CHEMBL865	206203	113	3H-PYRILAMINE	-97	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	1	4	3.0	Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1	None
		3337	206367	27	3H-PYRILAMINE	-1513	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	206367	27	3H-PYRILAMINE	-1513	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	206367	27	3H-PYRILAMINE	-1513	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	206367	27	3H-PYRILAMINE	-1513	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	206367	27	3H-PYRILAMINE	-1513	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		444	206666	53	3H-PYRILAMINE	-2089	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	239	3	1	2	3.3	CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1	None
		CHEMBL894	206666	53	3H-PYRILAMINE	-2089	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	239	3	1	2	3.3	CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1	None
		16231	207509	57	3H-MEPYRAMINE	-7	17	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	229	1	5	6	-1.1	N=C(N)NC(=O)c1nc(Cl)c(N)nc1N	None
		CHEMBL945	207509	57	3H-MEPYRAMINE	-7	17	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	229	1	5	6	-1.1	N=C(N)NC(=O)c1nc(Cl)c(N)nc1N	None
		165193	215945	0	3H-doxepin	-42657	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		62882	215945	0	3H-doxepin	-42657	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		66366	215945	0	3H-doxepin	-42657	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		11954224	215953	0	3H-PYRILAMINE	-141253	58	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		None	215958	0	3H-MEPYRAMINE	-63095	19	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	421	9	1	6	4.3	COC1=C(C(=CC=C1)OC)OCCNCC2C(OC3=CC=CC=C3O2)C4=CC=CC=C4	None
		25058166	215960	0	3H-PYRILAMINE	-5011	27	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		6852389	215960	0	3H-PYRILAMINE	-5011	27	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		44134711	215991	0	3H-MEPYRAMINE	-112201	14	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	340	6	2	4	2.8	CCC1=CC(=C(C(=C1O)C(=O)NCC2CCCN2CC)OC)Cl	None
		None	215993	0	3H-PYRILAMINE	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	2	0	4	3.6	CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C.Cl	None
		104911	216019	0	3H-PYRILAMINE	-41686	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	530	7	0	5	5.1	COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.Cl.Cl.Cl	None
		104911	216019	0	3H-PYRILAMINE	-41686	37	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	530	7	0	5	5.1	COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.Cl.Cl.Cl	None
		131632304	216037	0	3H-MEPYRAMINE	-70794	12	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	4	1	5	0.9	CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4	None
		119380	216129	0	3H-PYRILAMINE	-1	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	166	1	0	3	1.8	CC1=NOC(=C1)C2CCCN2C	None
		None	216154	0	3H-doxepin	-	1	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	2	1	4	2.4	C1C(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])C(=N1)C3=CC=CC=C3	None
		None	216155	0	3H-doxepin	1	2	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	1	0	7	2.6	CN1CCC2=CC3=C(C=C2C1C4C5=C(C6=C(C=C5)OCO6)C(=O)O4)OCO3	None
		25137849	216179	0	3H-PYRILAMINE	-4	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
		71290	216179	0	3H-PYRILAMINE	-4	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
		None	216249	0	3H-MEPYRAMINE	-501	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	468	12	0	9	-0.1	C1COCCN1CCCN2CN(CN(C2)CCCN3CCOCC3)CCCN4CCOCC4	None
		None	216250	0	3H-MEPYRAMINE	-1258	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	434	6	4	8	2.2	CC(C)O.COC1=C(C=CC(=C1)CC2COC(=O)C2(CC3=CC(=C(C=C3)O)OC)O)O	None
		None	216251	0	3H-MEPYRAMINE	-3981	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	234	2	1	3	2.0	CC(=O)NC1=C(C(=C(C=C1F)F)F)[N+](=O)[O-]	None
		None	216252	0	3H-MEPYRAMINE	-4677	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	0	1	2	4.0	CC12CCC(CC1CCC3C2CCC4(C3CCC4=O)C)(C#C)O	None
		None	216253	0	3H-MEPYRAMINE	-6025	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	5	1	3	4.5	CCCC1=CC2=C(C=C1NC(=O)C3C(C3(C)C)C=C(C)C)OCO2	None
		None	216311	0	3H-PYRILAMINE	-1	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	240	7	4	6	-0.8	C(C(C(=O)O)N)SSCC(C(=O)O)N	None
		None	216311	0	3H-PYRILAMINE	-1	33	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	240	7	4	6	-0.8	C(C(C(=O)O)N)SSCC(C(=O)O)N	None
		None	216312	0	3H-PYRILAMINE	-1	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	4	2	3	0.2	CSCCC(C(=O)O)N	None
		None	216312	0	3H-PYRILAMINE	-1	33	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	4	2	3	0.2	CSCCC(C(=O)O)N	None
		None	216313	0	3H-PYRILAMINE	-1	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	135	3	3	3	-0.3	C(CS)C(C(=O)O)N	None
		None	216313	0	3H-PYRILAMINE	-1	33	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	135	3	3	3	-0.3	C(CS)C(C(=O)O)N	None
		None	216314	0	3H-PYRILAMINE	-1	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	121	2	3	3	-0.7	C(C(C(=O)O)N)S	None
		None	216314	0	3H-PYRILAMINE	-1	33	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	121	2	3	3	-0.7	C(C(C(=O)O)N)S	None
		None	216315	0	3H-PYRILAMINE	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	117	0	1	3	-0.0	C1CSC(=O)C1N	None
		None	216316	0	3H-PYRILAMINE	-1	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	3	3	3	-1.4	C(C(C(=O)O)N)S(=O)O	None
		None	216316	0	3H-PYRILAMINE	-1	39	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	3	3	3	-1.4	C(C(C(=O)O)N)S(=O)O	None
		None	216317	0	3H-PYRILAMINE	-1	38	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	3	3	4	-1.7	C(C(C(=O)O)N)S(=O)(=O)O	None
		None	216317	0	3H-PYRILAMINE	-1	38	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	3	3	4	-1.7	C(C(C(=O)O)N)S(=O)(=O)O	None
		None	216318	0	3H-PYRILAMINE	-1	30	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	183	4	3	4	-1.3	C(CS(=O)(=O)O)C(C(=O)O)N	None
		None	216325	0	3H-PYRILAMINE	-13	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	2	1	2	1.2	CC(C(=O)C1=CC=CC=C1)N	None
		1576	216326	0	3H-PYRILAMINE	-16	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	163	3	1	2	1.5	CC(C(=O)C1=CC=CC=C1)NC	None
		None	216327	0	3H-PYRILAMINE	-16	28	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	536	11	1	4	9.0	CC(C)C(=O)C12C(=O)C(=C(C(C1=O)(CC(C2(C)CCC=C(C)C)CC=C(C)C)CC=C(C)C)O)CC=C(C)C	None
		4978	216328	0	3H-PYRILAMINE	-16	28	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	520	1	7	9	4.3	CC1=CC(=C2C3=C1C4=C5C(=C(C=C4CO)O)C(=O)C6=C(C=C(C7=C6C5=C3C8=C7C(=CC(=C8C2=O)O)O)O)O)O	None
		None	216329	0	3H-PYRILAMINE	-3	28	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	464	4	8	12	-0.6	C1=CC(=C(C=C1C2=C(C(=C3C(=CC(=O)C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)O)O)O	None
		None	216330	0	3H-PYRILAMINE	-281	28	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	610	6	10	16	-1.7	CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)O)O)O)O)O)O)O	None
		None	216331	0	3H-PYRILAMINE	-1	28	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	448	3	7	11	0.4	CC1C(C(C(C(O1)OC2=C(OC3=CC(=O)C=C(C3=C2O)O)C4=CC(=C(C=C4)O)O)O)O)O	None
		None	216388	0	3H-PYRILAMINE	1	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	313	5	1	3	3.5	CN(C)CC(C1=CC=C(C=C1)OC)C2(CCCCC2)O.Cl	None
		135269	216389	0	3H-PYRILAMINE	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	222	5	1	3	2.5	CCCCC(=O)OC1=CC=CC=C1C(=O)O	None
		5018304	216391	0	3H-PYRILAMINE	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	317	4	1	3	0.0	C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[Na+]	None
		84003	216392	0	3H-PYRILAMINE	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	376	6	5	7	-0.0	C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O	None
		119828	216394	0	3H-PYRILAMINE	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	370	5	1	5	3.5	CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C	None
		None	216395	0	3H-PYRILAMINE	-7	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	517	8	2	5	5.2	CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)NCCC4=CC=C(C=C4)NC(=O)C	None
		None	216450	0	UNDEFINED	-660	28	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
		None	216450	0	Functional	-660	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
		None	216489	0	3H-PYRILAMINE	-4570	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	347	6	0	3	5.0	CC(=O)N(CC1=CC=CC=C1OC)C2=CC=CC=C2OC3=CC=CC=C3	None
		None	216493	0	3H-PYRILAMINE	-10471285	17	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	372	2	1	3	4.4	CC(C)(C)C1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=C(C=CC=N3)Cl	None
		None	216494	0	3H-Strychnine	-1	13	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	399	7	4	5	1.8	CN(C)CC(C1=CC=C(C=C1)O)C2(CCCCC2)O.C(CC(=O)O)C(=O)O.O	None
		1233	2515	0	3H-MEPYRAMINE	-19	3	Rat	4.0	pKi	=	4	Binding	NoneNone	PDSP KiDatabase	244	5	3	3	1.0	CNC(=S)NCCSCc1nc[nH]c1C	None
		1548992	2515	0	3H-MEPYRAMINE	-19	3	Rat	4.0	pKi	=	4	Binding	NoneNone	PDSP KiDatabase	244	5	3	3	1.0	CNC(=S)NCCSCc1nc[nH]c1C	None
		CHEMBL275446	2515	0	3H-MEPYRAMINE	-19	3	Rat	4.0	pKi	=	4	Binding	NoneNone	PDSP KiDatabase	244	5	3	3	1.0	CNC(=S)NCCSCc1nc[nH]c1C	None
		DB08805	2515	0	3H-MEPYRAMINE	-19	3	Rat	4.0	pKi	=	4	Binding	NoneNone	PDSP KiDatabase	244	5	3	3	1.0	CNC(=S)NCCSCc1nc[nH]c1C	None
		3036864	202754	19	3H-MEPYRAMINE	-416	28	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1256645	202754	19	3H-MEPYRAMINE	-416	28	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1814790	202754	19	3H-MEPYRAMINE	-416	28	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL62	202754	19	3H-MEPYRAMINE	-416	28	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		46882664	5717	0	UNDEFINED	-2	5	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	494	8	2	8	3.6	CCOc1cc(CN2CCC(Nc3nc4cc(Cl)c(S(N)(=O)=O)cc4o3)CC2)ccc1OC	None
		CHEMBL1078240	5717	0	UNDEFINED	-2	5	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	494	8	2	8	3.6	CCOc1cc(CN2CCC(Nc3nc4cc(Cl)c(S(N)(=O)=O)cc4o3)CC2)ccc1OC	None
		11545813	181194	0	UNDEFINED	-24	7	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	400	6	0	3	5.2	O=C(CCCN1C2CCC1CN(c1ccc(Cl)cc1)CC2)c1ccc(F)cc1	None
		CHEMBL476109	181194	0	UNDEFINED	-24	7	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	400	6	0	3	5.2	O=C(CCCN1C2CCC1CN(c1ccc(Cl)cc1)CC2)c1ccc(F)cc1	None
		21830793	91835	10	3H-8-OH-DPAT	-6760	45	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	None
		CHEMBL2413154	91835	10	3H-8-OH-DPAT	-6760	45	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	None
		2	3261	23	3H-PYRILAMINE	-218	29	Guinea pig	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
		54562	3261	23	3H-PYRILAMINE	-218	29	Guinea pig	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
		CHEMBL240773	3261	23	3H-PYRILAMINE	-218	29	Guinea pig	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
		None	216342	0	3H-PYRILAMINE	-194	19	Guinea pig	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	246	2	1	4	1.6	CCCN1CCCC2C1CC3=CN=C(N=C3C2)N	None
		1427	2013	54	3H-MEPYRAMINE	-5	27	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		357	2013	54	3H-MEPYRAMINE	-5	27	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		3696	2013	54	3H-MEPYRAMINE	-5	27	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL11	2013	54	3H-MEPYRAMINE	-5	27	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		DB00458	2013	54	3H-MEPYRAMINE	-5	27	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		2337	3256	77	3H-PYRILAMINE	1	62	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		2337	3256	77	3H-PYRILAMINE	-1	62	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	3H-PYRILAMINE	1	62	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	3H-PYRILAMINE	-1	62	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	3H-PYRILAMINE	1	62	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	3H-PYRILAMINE	-1	62	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	3H-PYRILAMINE	1	62	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	3H-PYRILAMINE	-1	62	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	3H-PYRILAMINE	1	62	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	3H-PYRILAMINE	-1	62	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		1224	1432	83	3H-trans-H2-PAT,(-)	-2	13	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		3100	1432	83	3H-trans-H2-PAT,(-)	-2	13	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		8980	1432	83	3H-trans-H2-PAT,(-)	-2	13	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		916	1432	83	3H-trans-H2-PAT,(-)	-2	13	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		CHEMBL657	1432	83	3H-trans-H2-PAT,(-)	-2	13	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		DB01075	1432	83	3H-trans-H2-PAT,(-)	-2	13	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		1209	1658	75	3H-doxepin	-144	32	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		203	1658	75	3H-doxepin	-144	32	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		3386	1658	75	3H-doxepin	-144	32	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		CHEMBL41	1658	75	3H-doxepin	-144	32	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		DB00472	1658	75	3H-doxepin	-144	32	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		213	3853	55	3H-PYRILAMINE	-8	44	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		2717	3853	55	3H-PYRILAMINE	-8	44	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		5533	3853	55	3H-PYRILAMINE	-8	44	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		CHEMBL621	3853	55	3H-PYRILAMINE	-8	44	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		DB00656	3853	55	3H-PYRILAMINE	-8	44	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		1353	1911	93	3H-PYRILAMINE	-489	83	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-PYRILAMINE	-489	83	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-PYRILAMINE	-489	83	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-PYRILAMINE	-489	83	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-PYRILAMINE	-489	83	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1222	1664	49	3H-PYRILAMINE	-17	33	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3396	1664	49	3H-PYRILAMINE	-17	33	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		85	1664	49	3H-PYRILAMINE	-17	33	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL46516	1664	49	3H-PYRILAMINE	-17	33	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		DB04842	1664	49	3H-PYRILAMINE	-17	33	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		11954259	215979	0	3H-PYRILAMINE	-19	43	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
		3294	2006	111	3H-PYRILAMINE	-14	45	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		71360	2006	111	3H-PYRILAMINE	-14	45	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		87	2006	111	3H-PYRILAMINE	-14	45	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		CHEMBL14376	2006	111	3H-PYRILAMINE	-14	45	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		DB04946	2006	111	3H-PYRILAMINE	-14	45	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		1222	881	0	3H-MEPYRAMINE	1	2	Guinea pig	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		2678	881	0	3H-MEPYRAMINE	1	2	Guinea pig	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		581	881	0	3H-MEPYRAMINE	1	2	Guinea pig	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		CHEMBL1000	881	0	3H-MEPYRAMINE	1	2	Guinea pig	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		DB00341	881	0	3H-MEPYRAMINE	1	2	Guinea pig	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		100	3805	58	3H-MEPYRAMINE	-23	55	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	3805	58	3H-MEPYRAMINE	-23	55	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	3805	58	3H-MEPYRAMINE	-23	55	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	3805	58	3H-MEPYRAMINE	-23	55	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	3805	58	3H-MEPYRAMINE	-23	55	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		21722	17992	31	3H-doxepin	1	6	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	None
		CHEMBL126224	17992	31	3H-doxepin	1	6	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	None
		2995	204405	53	3H-doxepin	-14	23	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL1696	204405	53	3H-doxepin	-14	23	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL72	204405	53	3H-doxepin	-14	23	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		16667681	216153	0	3H-doxepin	4	3	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	390	7	1	5	3.5	CN(C)CCCC1=CC=CC=N1.C1=CC(=CC=C1OC(=O)C=CC(=O)O)Cl	None
		45485525	197799	0	UNDEFINED	-	1	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	337	7	1	2	4.8	Cc1ccc(CCCCN2CCC(C(O)c3ccccc3)CC2)cc1	None
		CHEMBL572034	197799	0	UNDEFINED	-	1	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	337	7	1	2	4.8	Cc1ccc(CCCCN2CCC(C(O)c3ccccc3)CC2)cc1	None
		2995	204405	53	3H-PYRILAMINE	-42	23	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL1696	204405	53	3H-PYRILAMINE	-42	23	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL72	204405	53	3H-PYRILAMINE	-42	23	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		12057539	208041	42	3H-MEPYRAMINE	-676	20	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	208041	42	3H-MEPYRAMINE	-676	20	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	208041	42	3H-MEPYRAMINE	-676	20	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		1204	1932	119	3H-MEPYRAMINE	-501	24	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	3H-MEPYRAMINE	-501	24	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	3H-MEPYRAMINE	-501	24	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	3H-MEPYRAMINE	-501	24	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	3H-MEPYRAMINE	-501	24	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	3H-MEPYRAMINE	-501	24	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1204	1932	119	3H-MEPYRAMINE	-501	24	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	3H-MEPYRAMINE	-501	24	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	3H-MEPYRAMINE	-501	24	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	3H-MEPYRAMINE	-501	24	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	3H-MEPYRAMINE	-501	24	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	3H-MEPYRAMINE	-501	24	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		219050	3373	25	3H-PYRILAMINE	-794	21	Guinea pig	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	None
		52	3373	25	3H-PYRILAMINE	-794	21	Guinea pig	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	None
		CHEMBL431367	3373	25	3H-PYRILAMINE	-794	21	Guinea pig	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	None
		2444	14478	26	3H-MEPYRAMINE	-1	2	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	333	6	0	2	4.1	CN(C)CCOC(c1ccccc1)c1ccc(Br)cc1	None
		CHEMBL1201245	14478	26	3H-MEPYRAMINE	-1	2	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	333	6	0	2	4.1	CN(C)CCOC(c1ccccc1)c1ccc(Br)cc1	None
		1224	1432	83	3H-MEPYRAMINE	-2	13	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		3100	1432	83	3H-MEPYRAMINE	-2	13	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		8980	1432	83	3H-MEPYRAMINE	-2	13	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		916	1432	83	3H-MEPYRAMINE	-2	13	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		CHEMBL657	1432	83	3H-MEPYRAMINE	-2	13	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		DB01075	1432	83	3H-MEPYRAMINE	-2	13	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		1224	1432	83	3H-MEPYRAMINE	1	13	Guinea pig	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		3100	1432	83	3H-MEPYRAMINE	1	13	Guinea pig	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		8980	1432	83	3H-MEPYRAMINE	1	13	Guinea pig	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		916	1432	83	3H-MEPYRAMINE	1	13	Guinea pig	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		CHEMBL657	1432	83	3H-MEPYRAMINE	1	13	Guinea pig	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		DB01075	1432	83	3H-MEPYRAMINE	1	13	Guinea pig	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		2435	3590	83	3H-PYRILAMINE	-95	48	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		60149	3590	83	3H-PYRILAMINE	-95	48	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		98	3590	83	3H-PYRILAMINE	-95	48	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		CHEMBL12713	3590	83	3H-PYRILAMINE	-95	48	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		DB06144	3590	83	3H-PYRILAMINE	-95	48	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		2865	4143	73	3H-PYRILAMINE	-58	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	4143	73	3H-PYRILAMINE	-58	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	4143	73	3H-PYRILAMINE	-58	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	4143	73	3H-PYRILAMINE	-58	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	4143	73	3H-PYRILAMINE	-58	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		37459	746	13	3H-MEPYRAMINE	-3019	25	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		62	746	13	3H-MEPYRAMINE	-3019	25	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		CHEMBL8514	746	13	3H-MEPYRAMINE	-3019	25	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		1621	2429	17	3H-MEPYRAMINE	-4570	45	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		17	2429	17	3H-MEPYRAMINE	-4570	45	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		5761	2429	17	3H-MEPYRAMINE	-4570	45	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL263881	2429	17	3H-MEPYRAMINE	-4570	45	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB04829	2429	17	3H-MEPYRAMINE	-4570	45	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		46882180	5841	0	UNDEFINED	-5	6	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	482	7	2	7	3.7	CCOc1cc(CN2CCC(Nc3nc4cc(Cl)c(S(N)(=O)=O)cc4o3)CC2)ccc1F	None
		CHEMBL1079180	5841	0	UNDEFINED	-5	6	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	482	7	2	7	3.7	CCOc1cc(CN2CCC(Nc3nc4cc(Cl)c(S(N)(=O)=O)cc4o3)CC2)ccc1F	None
		None	216341	0	3H-PYRILAMINE	-1819	19	Guinea pig	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	451	8	2	4	3.2	CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=CNC4=CC=CC2=C34)N(C1)CC=C	None
		135398737	958	93	3H-pirilamine	-4	89	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-pirilamine	-4	89	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-pirilamine	-4	89	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-pirilamine	-4	89	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-pirilamine	-4	89	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		100	3805	58	3H-PYRILAMINE	-7	55	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	3805	58	3H-PYRILAMINE	-7	55	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	3805	58	3H-PYRILAMINE	-7	55	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	3805	58	3H-PYRILAMINE	-7	55	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	3805	58	3H-PYRILAMINE	-7	55	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		1224	1432	83	UNDEFINED	-2	13	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		3100	1432	83	UNDEFINED	-2	13	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		8980	1432	83	UNDEFINED	-2	13	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		916	1432	83	UNDEFINED	-2	13	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		CHEMBL657	1432	83	UNDEFINED	-2	13	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		DB01075	1432	83	UNDEFINED	-2	13	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		9906978	42711	2	UNDEFINED	-28	12	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	361	6	1	3	4.0	O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1	None
		CHEMBL150161	42711	2	UNDEFINED	-28	12	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	361	6	1	3	4.0	O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1	None
		37459	746	13	3H-MEPYRAMINE	-1174	25	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		62	746	13	3H-MEPYRAMINE	-1174	25	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		CHEMBL8514	746	13	3H-MEPYRAMINE	-1174	25	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		1224	1432	83	3H-MEPYRAMINE	-2	13	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		3100	1432	83	3H-MEPYRAMINE	-2	13	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		8980	1432	83	3H-MEPYRAMINE	-2	13	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		916	1432	83	3H-MEPYRAMINE	-2	13	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		CHEMBL657	1432	83	3H-MEPYRAMINE	-2	13	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		DB01075	1432	83	3H-MEPYRAMINE	-2	13	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		2389	3331	118	3H-PYRILAMINE	-46	67	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-PYRILAMINE	-46	67	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-PYRILAMINE	-46	67	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-PYRILAMINE	-46	67	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-PYRILAMINE	-46	67	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		2865	4143	73	3H-PYRILAMINE	-58	53	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	4143	73	3H-PYRILAMINE	-58	53	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	4143	73	3H-PYRILAMINE	-58	53	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	4143	73	3H-PYRILAMINE	-58	53	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	4143	73	3H-PYRILAMINE	-58	53	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		90475904	216022	0	3H-doxepin	-7	6	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(C)CCC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2	None
		1971	2866	38	3H-MEPYRAMINE	-1	30	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		2404	2866	38	3H-MEPYRAMINE	-1	30	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		4543	2866	38	3H-MEPYRAMINE	-1	30	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		CHEMBL445	2866	38	3H-MEPYRAMINE	-1	30	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		DB00540	2866	38	3H-MEPYRAMINE	-1	30	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		1204	1932	119	3H-Histamine	-501	24	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	3H-Histamine	-501	24	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	3H-Histamine	-501	24	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	3H-Histamine	-501	24	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	3H-Histamine	-501	24	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	3H-Histamine	-501	24	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		11957566	184	25	3H-MEPYRAMINE	-812	9	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	None
		1219	184	25	3H-MEPYRAMINE	-812	9	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	None
		3296	184	25	3H-MEPYRAMINE	-812	9	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	None
		950	184	25	3H-MEPYRAMINE	-812	9	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	None
		CHEMBL285755	184	25	3H-MEPYRAMINE	-812	9	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	None
		2142	3096	58	3H-MEPYRAMINE	-263	36	Human	4.8	pKi	=	4.8	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4920903	3096	58	3H-MEPYRAMINE	-263	36	Human	4.8	pKi	=	4.8	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		502	3096	58	3H-MEPYRAMINE	-263	36	Human	4.8	pKi	=	4.8	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		5775	3096	58	3H-MEPYRAMINE	-263	36	Human	4.8	pKi	=	4.8	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		CHEMBL597	3096	58	3H-MEPYRAMINE	-263	36	Human	4.8	pKi	=	4.8	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		DB00692	3096	58	3H-MEPYRAMINE	-263	36	Human	4.8	pKi	=	4.8	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		1621	2429	17	3H-PYRILAMINE	-4570	45	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		17	2429	17	3H-PYRILAMINE	-4570	45	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		5761	2429	17	3H-PYRILAMINE	-4570	45	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL263881	2429	17	3H-PYRILAMINE	-4570	45	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB04829	2429	17	3H-PYRILAMINE	-4570	45	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		1209	1658	75	3H-PYRILAMINE	-223	32	Guinea pig	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		203	1658	75	3H-PYRILAMINE	-223	32	Guinea pig	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		3386	1658	75	3H-PYRILAMINE	-223	32	Guinea pig	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		CHEMBL41	1658	75	3H-PYRILAMINE	-223	32	Guinea pig	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		DB00472	1658	75	3H-PYRILAMINE	-223	32	Guinea pig	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		2389	3331	118	3H-PYRILAMINE	-346	67	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-PYRILAMINE	-346	67	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-PYRILAMINE	-346	67	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-PYRILAMINE	-346	67	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-PYRILAMINE	-346	67	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		45485535	197621	0	UNDEFINED	-	1	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	399	7	1	2	5.6	Cc1ccc(CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1	None
		CHEMBL570695	197621	0	UNDEFINED	-	1	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	399	7	1	2	5.6	Cc1ccc(CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1	None
		44395741	181581	0	UNDEFINED	-10	10	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	360	6	0	3	4.3	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	None
		CHEMBL476935	181581	0	UNDEFINED	-10	10	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	360	6	0	3	4.3	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	None
		CHEMBL558392	181581	0	UNDEFINED	-10	10	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	360	6	0	3	4.3	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	None
		1001	620	95	3H-MEPYRAMINE	-3	2	Human	3.8	pKi	=	3.8	Binding	NoneNone	PDSP KiDatabase	121	2	1	1	1.2	NCCc1ccccc1	None
		2144	620	95	3H-MEPYRAMINE	-3	2	Human	3.8	pKi	=	3.8	Binding	NoneNone	PDSP KiDatabase	121	2	1	1	1.2	NCCc1ccccc1	None
		CHEMBL610	620	95	3H-MEPYRAMINE	-3	2	Human	3.8	pKi	=	3.8	Binding	NoneNone	PDSP KiDatabase	121	2	1	1	1.2	NCCc1ccccc1	None
		DB04325	620	95	3H-MEPYRAMINE	-3	2	Human	3.8	pKi	=	3.8	Binding	NoneNone	PDSP KiDatabase	121	2	1	1	1.2	NCCc1ccccc1	None
		1427	2013	54	3H-MEPYRAMINE	-1	27	Guinea pig	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		1427	2013	54	3H-doxepin	-5	27	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		357	2013	54	3H-MEPYRAMINE	-1	27	Guinea pig	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		357	2013	54	3H-doxepin	-5	27	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		3696	2013	54	3H-MEPYRAMINE	-1	27	Guinea pig	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		3696	2013	54	3H-doxepin	-5	27	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL11	2013	54	3H-MEPYRAMINE	-1	27	Guinea pig	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL11	2013	54	3H-doxepin	-5	27	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		DB00458	2013	54	3H-MEPYRAMINE	-1	27	Guinea pig	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		DB00458	2013	54	3H-doxepin	-5	27	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		100	3805	58	3H-doxepin	-7	55	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	3805	58	3H-doxepin	-7	55	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	3805	58	3H-doxepin	-7	55	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	3805	58	3H-doxepin	-7	55	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	3805	58	3H-doxepin	-7	55	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		44622869	197717	0	UNDEFINED	-	1	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	371	5	1	2	5.1	Cc1ccc(CN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1	None
		CHEMBL571390	197717	0	UNDEFINED	-	1	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	371	5	1	2	5.1	Cc1ccc(CN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1	None
		100	3805	58	UNDEFINED	-7	55	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	3805	58	UNDEFINED	-7	55	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	3805	58	UNDEFINED	-7	55	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	3805	58	UNDEFINED	-7	55	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	3805	58	UNDEFINED	-7	55	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2389	3331	118	3H-PYRILAMINE	-346	67	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-PYRILAMINE	-346	67	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-PYRILAMINE	-346	67	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-PYRILAMINE	-346	67	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-PYRILAMINE	-346	67	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		12057539	208041	42	3H-doxepin	-676	20	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	208041	42	3H-doxepin	-676	20	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	208041	42	3H-doxepin	-676	20	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		186	1807	52	3H-PYRILAMINE	-269	17	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
		71781	1807	52	3H-PYRILAMINE	-269	17	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
		CHEMBL18972	1807	52	3H-PYRILAMINE	-269	17	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
		2105	3054	37	3H-PYRILAMINE	-2754	33	Guinea pig	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		47811	3054	37	3H-PYRILAMINE	-2754	33	Guinea pig	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		48	3054	37	3H-PYRILAMINE	-2754	33	Guinea pig	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		CHEMBL531	3054	37	3H-PYRILAMINE	-2754	33	Guinea pig	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		DB01186	3054	37	3H-PYRILAMINE	-2754	33	Guinea pig	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		135398737	958	93	UNDEFINED	-4	89	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	UNDEFINED	-4	89	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	UNDEFINED	-4	89	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	UNDEFINED	-4	89	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	UNDEFINED	-4	89	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		1224	1432	83	3H-MEPYRAMINE	-1	13	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		3100	1432	83	3H-MEPYRAMINE	-1	13	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		8980	1432	83	3H-MEPYRAMINE	-1	13	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		916	1432	83	3H-MEPYRAMINE	-1	13	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		CHEMBL657	1432	83	3H-MEPYRAMINE	-1	13	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		DB01075	1432	83	3H-MEPYRAMINE	-1	13	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		1353	1911	93	3H-doxepin	-489	83	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-doxepin	-489	83	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-doxepin	-489	83	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-doxepin	-489	83	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-doxepin	-489	83	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		None	216254	0	3H-MEPYRAMINE	-1412	19	Guinea pig	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	416	9	3	4	2.8	C1=CC(=CC=C1CCNC(N)SCCCC2=CN=CN2)I	None
		None	215992	0	3H-PYRILAMINE	-1	11	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	522	10	0	3	6.2	C1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F.Cl.Cl	None
		2389	3331	118	3H-PYRILAMINE	-46	67	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-PYRILAMINE	-46	67	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-PYRILAMINE	-46	67	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-PYRILAMINE	-46	67	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-PYRILAMINE	-46	67	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		2274	3173	58	UNDEFINED	-3	31	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		4917	3173	58	UNDEFINED	-3	31	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		7279	3173	58	UNDEFINED	-3	31	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		CHEMBL728	3173	58	UNDEFINED	-3	31	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		DB00433	3173	58	UNDEFINED	-3	31	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		1353	1911	93	3H-PYRILAMINE	-213	83	Guinea pig	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1353	1911	93	3H-PYRILAMINE	-489	83	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-PYRILAMINE	-213	83	Guinea pig	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-PYRILAMINE	-489	83	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-PYRILAMINE	-213	83	Guinea pig	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-PYRILAMINE	-489	83	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-PYRILAMINE	-213	83	Guinea pig	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-PYRILAMINE	-489	83	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-PYRILAMINE	-213	83	Guinea pig	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-PYRILAMINE	-489	83	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		12057539	208041	42	3H-MEPYRAMINE	-3388	20	Guinea pig	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	208041	42	3H-MEPYRAMINE	-3388	20	Guinea pig	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	208041	42	3H-MEPYRAMINE	-3388	20	Guinea pig	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		214	3860	58	3H-MEPYRAMINE	-218	30	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2740	3860	58	3H-MEPYRAMINE	-218	30	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5566	3860	58	3H-MEPYRAMINE	-218	30	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		66064	3860	58	3H-MEPYRAMINE	-218	30	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL422	3860	58	3H-MEPYRAMINE	-218	30	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00831	3860	58	3H-MEPYRAMINE	-218	30	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		11653679	181191	1	UNDEFINED	-28	11	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	374	6	0	3	4.7	O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	None
		CHEMBL476108	181191	1	UNDEFINED	-28	11	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	374	6	0	3	4.7	O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	None
		1353	1911	93	UNDEFINED	-489	83	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	UNDEFINED	-489	83	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	UNDEFINED	-489	83	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	UNDEFINED	-489	83	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	UNDEFINED	-489	83	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1212	1662	50	3H-MEPYRAMINE	-38	65	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	1662	50	3H-MEPYRAMINE	-38	65	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	1662	50	3H-MEPYRAMINE	-38	65	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	1662	50	3H-MEPYRAMINE	-38	65	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	1662	50	3H-MEPYRAMINE	-38	65	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2274	3173	58	3H-doxepin	-3	31	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		4917	3173	58	3H-doxepin	-3	31	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		7279	3173	58	3H-doxepin	-3	31	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		CHEMBL728	3173	58	3H-doxepin	-3	31	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		DB00433	3173	58	3H-doxepin	-3	31	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		2337	3256	77	3H-PYRILAMINE	-1	62	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		2337	3256	77	3H-PYRILAMINE	1	62	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	3H-PYRILAMINE	-1	62	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	3H-PYRILAMINE	1	62	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	3H-PYRILAMINE	-1	62	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	3H-PYRILAMINE	1	62	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	3H-PYRILAMINE	-1	62	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	3H-PYRILAMINE	1	62	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	3H-PYRILAMINE	-1	62	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	3H-PYRILAMINE	1	62	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		2389	3331	118	UNDEFINED	-46	67	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	UNDEFINED	-46	67	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	UNDEFINED	-46	67	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	UNDEFINED	-46	67	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	UNDEFINED	-46	67	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		100	3805	58	3H-PYRILAMINE	-7	55	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	3805	58	3H-PYRILAMINE	-7	55	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	3805	58	3H-PYRILAMINE	-7	55	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	3805	58	3H-PYRILAMINE	-7	55	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	3805	58	3H-PYRILAMINE	-7	55	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		1204	1932	119	Functional	-501	24	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	Functional	-501	24	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	Functional	-501	24	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	Functional	-501	24	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	Functional	-501	24	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	Functional	-501	24	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		None	217133	0	UNDEFINED	-58	11	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	116	4	0	2	1.4	CCCCN(C)N=O	None
		1353	1911	93	3H-doxepin	-489	83	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-doxepin	-489	83	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-doxepin	-489	83	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-doxepin	-489	83	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-doxepin	-489	83	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		2771	195017	74	3H-PYRILAMINE	-2	27	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL1200781	195017	74	3H-PYRILAMINE	-2	27	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL549	195017	74	3H-PYRILAMINE	-2	27	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		2771	195017	74	3H-PYRILAMINE	-9	27	Guinea pig	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL1200781	195017	74	3H-PYRILAMINE	-9	27	Guinea pig	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL549	195017	74	3H-PYRILAMINE	-9	27	Guinea pig	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		46882181	5681	0	UNDEFINED	1	5	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	536	10	2	8	5.1	CCOc1cc(CN2CCC(Nc3nc4cc(NS(=O)(=O)c5ccccc5)ccc4o3)CC2)ccc1OC	None
		CHEMBL1077908	5681	0	UNDEFINED	1	5	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	536	10	2	8	5.1	CCOc1cc(CN2CCC(Nc3nc4cc(NS(=O)(=O)c5ccccc5)ccc4o3)CC2)ccc1OC	None
		135398737	958	93	3H-Histamine	2	89	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-Histamine	2	89	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-Histamine	2	89	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-Histamine	2	89	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-Histamine	2	89	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		135398737	958	93	3H-PYRILAMINE	2	89	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-PYRILAMINE	2	89	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-PYRILAMINE	2	89	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-PYRILAMINE	2	89	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-PYRILAMINE	2	89	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		1400	1957	70	3H-MEPYRAMINE	2	3	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		3658	1957	70	3H-MEPYRAMINE	2	3	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		7199	1957	70	3H-MEPYRAMINE	2	3	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		91513	1957	70	3H-MEPYRAMINE	2	3	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		CHEMBL896	1957	70	3H-MEPYRAMINE	2	3	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		DB00557	1957	70	3H-MEPYRAMINE	2	3	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		1427	2013	54	3H-PYRILAMINE	-1	27	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		357	2013	54	3H-PYRILAMINE	-1	27	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		3696	2013	54	3H-PYRILAMINE	-1	27	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL11	2013	54	3H-PYRILAMINE	-1	27	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		DB00458	2013	54	3H-PYRILAMINE	-1	27	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		1227	2489	43	3H-MEPYRAMINE	-2	12	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		2331	2489	43	3H-MEPYRAMINE	-2	12	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		3957	2489	43	3H-MEPYRAMINE	-2	12	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		4992	2489	43	3H-MEPYRAMINE	-2	12	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		CHEMBL511	2489	43	3H-MEPYRAMINE	-2	12	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		DB06691	2489	43	3H-MEPYRAMINE	-2	12	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		135398745	2914	112	3H-PYRILAMINE	1	65	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-PYRILAMINE	1	65	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-PYRILAMINE	1	65	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-PYRILAMINE	1	65	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		2284	3182	33	3H-doxepin	1	29	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		2284	3182	33	UNDEFINED	1	29	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		4926	3182	33	3H-doxepin	1	29	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		4926	3182	33	UNDEFINED	1	29	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		7281	3182	33	3H-doxepin	1	29	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		7281	3182	33	UNDEFINED	1	29	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		CHEMBL564	3182	33	3H-doxepin	1	29	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		CHEMBL564	3182	33	UNDEFINED	1	29	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		DB00420	3182	33	3H-doxepin	1	29	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		DB00420	3182	33	UNDEFINED	1	29	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		2600	3779	74	3H-MEPYRAMINE	1	13	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		2608	3779	74	3H-MEPYRAMINE	1	13	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		5405	3779	74	3H-MEPYRAMINE	1	13	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		CHEMBL17157	3779	74	3H-MEPYRAMINE	1	13	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		DB00342	3779	74	3H-MEPYRAMINE	1	13	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		46780481	107531	20	3H-PYRILAMINE	-11	53	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		9903970	107531	20	3H-PYRILAMINE	-11	53	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3187365	107531	20	3H-PYRILAMINE	-11	53	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3544974	107531	20	3H-PYRILAMINE	-11	53	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		135398737	958	93	3H-trans-H2-PAT,(-)	-2	89	Guinea pig	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-trans-H2-PAT,(-)	-2	89	Guinea pig	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-trans-H2-PAT,(-)	-2	89	Guinea pig	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-trans-H2-PAT,(-)	-2	89	Guinea pig	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-trans-H2-PAT,(-)	-2	89	Guinea pig	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		135398737	958	93	3H-PYRILAMINE	-2	89	Guinea pig	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-PYRILAMINE	-2	89	Guinea pig	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-PYRILAMINE	-2	89	Guinea pig	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-PYRILAMINE	-2	89	Guinea pig	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-PYRILAMINE	-2	89	Guinea pig	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		2337	3256	77	3H-PYRILAMINE	1	62	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	3H-PYRILAMINE	1	62	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	3H-PYRILAMINE	1	62	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	3H-PYRILAMINE	1	62	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	3H-PYRILAMINE	1	62	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		2564	206184	51	3H-MEPYRAMINE	2	3	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	290	6	0	3	3.4	CN(C)CCOC(c1ccc(Cl)cc1)c1ccccn1	None
		CHEMBL864	206184	51	3H-MEPYRAMINE	2	3	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	290	6	0	3	3.4	CN(C)CCOC(c1ccc(Cl)cc1)c1ccccn1	None
		None	216176	0	3H-MEPYRAMINE	-	1	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	296	2	0	3	4.2	CN1CCC(C1)CN2C3=CC=CC=C3SC4=CC=CC=C42	None
		135398737	958	93	UNDEFINED	2	89	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	UNDEFINED	2	89	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	UNDEFINED	2	89	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	UNDEFINED	2	89	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	UNDEFINED	2	89	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		2284	3182	33	3H-MEPYRAMINE	-1	29	Guinea pig	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		4926	3182	33	3H-MEPYRAMINE	-1	29	Guinea pig	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		7281	3182	33	3H-MEPYRAMINE	-1	29	Guinea pig	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		CHEMBL564	3182	33	3H-MEPYRAMINE	-1	29	Guinea pig	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		DB00420	3182	33	3H-MEPYRAMINE	-1	29	Guinea pig	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		1227	2489	43	3H-PYRILAMINE	-2	12	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		2331	2489	43	3H-PYRILAMINE	-2	12	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		3957	2489	43	3H-PYRILAMINE	-2	12	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		4992	2489	43	3H-PYRILAMINE	-2	12	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		CHEMBL511	2489	43	3H-PYRILAMINE	-2	12	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		DB06691	2489	43	3H-PYRILAMINE	-2	12	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		1210	918	51	3H-MEPYRAMINE	-20	21	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		1213	918	51	3H-MEPYRAMINE	-20	21	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		2725	918	51	3H-MEPYRAMINE	-20	21	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		33036	918	51	3H-MEPYRAMINE	-20	21	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		4411	918	51	3H-MEPYRAMINE	-20	21	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		616	918	51	3H-MEPYRAMINE	-20	21	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		6976	918	51	3H-MEPYRAMINE	-20	21	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		716121	918	51	3H-MEPYRAMINE	-20	21	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL1201353	918	51	3H-MEPYRAMINE	-20	21	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL1554789	918	51	3H-MEPYRAMINE	-20	21	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL505	918	51	3H-MEPYRAMINE	-20	21	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		DB01114	918	51	3H-MEPYRAMINE	-20	21	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		DB13679	918	51	3H-MEPYRAMINE	-20	21	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		16667681	216153	0	3H-MEPYRAMINE	4	3	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	390	7	1	5	3.5	CN(C)CCCC1=CC=CC=N1.C1=CC(=CC=C1OC(=O)C=CC(=O)O)Cl	None
		2286	3183	51	3H-MEPYRAMINE	-2	30	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		4927	3183	51	3H-MEPYRAMINE	-2	30	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		7282	3183	51	3H-MEPYRAMINE	-2	30	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		CHEMBL643	3183	51	3H-MEPYRAMINE	-2	30	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		DB01069	3183	51	3H-MEPYRAMINE	-2	30	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		2389	3331	118	3H-PYRILAMINE	-52	67	Guinea pig	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-PYRILAMINE	-52	67	Guinea pig	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-PYRILAMINE	-52	67	Guinea pig	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-PYRILAMINE	-52	67	Guinea pig	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-PYRILAMINE	-52	67	Guinea pig	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		90475904	216022	0	3H-trans-H2-PAT,(-)	-7	6	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(C)CCC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2	None
		135398745	2914	112	3H-PYRILAMINE	1	65	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-PYRILAMINE	1	65	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-PYRILAMINE	1	65	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-PYRILAMINE	1	65	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		135398737	958	93	UNDEFINED	2	89	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	UNDEFINED	2	89	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	UNDEFINED	2	89	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	UNDEFINED	2	89	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	UNDEFINED	2	89	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		135398737	958	93	3H-doxepin	2	89	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-doxepin	2	89	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-doxepin	2	89	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-doxepin	2	89	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-doxepin	2	89	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		1613	2348	53	3H-PYRILAMINE	-3	44	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	2348	53	3H-PYRILAMINE	-3	44	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	2348	53	3H-PYRILAMINE	-3	44	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	2348	53	3H-PYRILAMINE	-3	44	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	2348	53	3H-PYRILAMINE	-3	44	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		135398745	2914	112	UNDEFINED	1	65	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	UNDEFINED	1	65	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	UNDEFINED	1	65	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	UNDEFINED	1	65	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		135398737	958	93	3H-pirilamine	-4	89	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-pirilamine	-4	89	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-pirilamine	-4	89	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-pirilamine	-4	89	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-pirilamine	-4	89	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		2286	3183	51	3H-MEPYRAMINE	-1	30	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		4927	3183	51	3H-MEPYRAMINE	-1	30	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		7282	3183	51	3H-MEPYRAMINE	-1	30	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		CHEMBL643	3183	51	3H-MEPYRAMINE	-1	30	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		DB01069	3183	51	3H-MEPYRAMINE	-1	30	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		100	3805	58	3H-MEPYRAMINE	-23	55	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	3805	58	3H-MEPYRAMINE	-23	55	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	3805	58	3H-MEPYRAMINE	-23	55	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	3805	58	3H-MEPYRAMINE	-23	55	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	3805	58	3H-MEPYRAMINE	-23	55	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		1228	3866	34	3H-MEPYRAMINE	-5	4	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		2763	3866	34	3H-MEPYRAMINE	-5	4	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		5282443	3866	34	3H-MEPYRAMINE	-5	4	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		CHEMBL855	3866	34	3H-MEPYRAMINE	-5	4	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		DB00427	3866	34	3H-MEPYRAMINE	-5	4	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		11291	98796	25	3H-MEPYRAMINE	-4	2	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	261	1	0	1	3.9	CN1CCC2=C(C1)C(c1ccccc1)c1ccccc12	None
		CHEMBL278398	98796	25	3H-MEPYRAMINE	-4	2	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	261	1	0	1	3.9	CN1CCC2=C(C1)C(c1ccccc1)c1ccccc12	None
		45485473	197335	0	UNDEFINED	-	1	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	457	9	1	4	5.4	COC(=O)c1ccc(CCCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1	None
		CHEMBL568892	197335	0	UNDEFINED	-	1	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	457	9	1	4	5.4	COC(=O)c1ccc(CCCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1	None
		1212	1662	50	UNDEFINED	-41	65	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	1662	50	UNDEFINED	-41	65	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	1662	50	UNDEFINED	-41	65	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	1662	50	UNDEFINED	-41	65	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	1662	50	UNDEFINED	-41	65	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2995	204405	53	3H-MEPYRAMINE	-14	23	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL1696	204405	53	3H-MEPYRAMINE	-14	23	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL72	204405	53	3H-MEPYRAMINE	-14	23	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		1204	1932	119	3H-MEPYRAMINE	-501	24	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	3H-MEPYRAMINE	-501	24	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	3H-MEPYRAMINE	-501	24	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	3H-MEPYRAMINE	-501	24	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	3H-MEPYRAMINE	-501	24	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	3H-MEPYRAMINE	-501	24	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1599	2341	50	3H-MEPYRAMINE	-2398	16	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	None
		3955	2341	50	3H-MEPYRAMINE	-2398	16	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	None
		7215	2341	50	3H-MEPYRAMINE	-2398	16	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	None
		CHEMBL841	2341	50	3H-MEPYRAMINE	-2398	16	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	None
		DB00836	2341	50	3H-MEPYRAMINE	-2398	16	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	None
		12057539	208041	42	3H-MEPYRAMINE	-3715	20	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	208041	42	3H-MEPYRAMINE	-3715	20	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	208041	42	3H-MEPYRAMINE	-3715	20	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		10456093	197509	0	UNDEFINED	-	1	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	443	9	2	3	5.4	O=C(O)c1ccc(CCCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1	None
		CHEMBL570033	197509	0	UNDEFINED	-	1	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	443	9	2	3	5.4	O=C(O)c1ccc(CCCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1	None
		44591134	176200	0	UNDEFINED	-169	6	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	535	11	0	5	7.7	CN(CCCN1c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1	None
		CHEMBL459373	176200	0	UNDEFINED	-169	6	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	535	11	0	5	7.7	CN(CCCN1c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1	None
		1204	1932	119	3H-MEPYRAMINE	-501	24	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	3H-MEPYRAMINE	-501	24	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	3H-MEPYRAMINE	-501	24	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	3H-MEPYRAMINE	-501	24	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	3H-MEPYRAMINE	-501	24	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	3H-MEPYRAMINE	-501	24	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1212	1662	50	3H-PYRILAMINE	-41	65	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		1212	1662	50	3H-doxepin	-41	65	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	1662	50	3H-PYRILAMINE	-41	65	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	1662	50	3H-doxepin	-41	65	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	1662	50	3H-PYRILAMINE	-41	65	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	1662	50	3H-doxepin	-41	65	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	1662	50	3H-PYRILAMINE	-41	65	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	1662	50	3H-doxepin	-41	65	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	1662	50	3H-PYRILAMINE	-41	65	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	1662	50	3H-doxepin	-41	65	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2337	3256	77	UNDEFINED	-1	62	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	UNDEFINED	-1	62	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	UNDEFINED	-1	62	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	UNDEFINED	-1	62	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	UNDEFINED	-1	62	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		37459	746	13	3H-MEPYRAMINE	-1174	25	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		62	746	13	3H-MEPYRAMINE	-1174	25	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		CHEMBL8514	746	13	3H-MEPYRAMINE	-1174	25	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		16667681	216153	0	3H-trans-H2-PAT,(-)	4	3	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	390	7	1	5	3.5	CN(C)CCCC1=CC=CC=N1.C1=CC(=CC=C1OC(=O)C=CC(=O)O)Cl	None
		1830	2590	44	3H-PYRILAMINE	-125	28	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		207	2590	44	3H-PYRILAMINE	-125	28	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		23897	2590	44	3H-PYRILAMINE	-125	28	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		CHEMBL460	2590	44	3H-PYRILAMINE	-125	28	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		DB01618	2590	44	3H-PYRILAMINE	-125	28	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		446220	133521	14	3H-PYRILAMINE	-19	45	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	303	3	0	5	1.9	COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C	None
		CHEMBL370805	133521	14	3H-PYRILAMINE	-19	45	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	303	3	0	5	1.9	COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C	None
		1615	167791	24	3H-PYRILAMINE	-5	44	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
		CHEMBL43048	167791	24	3H-PYRILAMINE	-5	44	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
		1353	1911	93	3H-MEPYRAMINE	-489	83	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-MEPYRAMINE	-489	83	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-MEPYRAMINE	-489	83	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-MEPYRAMINE	-489	83	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-MEPYRAMINE	-489	83	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		2284	3182	33	3H-MEPYRAMINE	-10	29	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		4926	3182	33	3H-MEPYRAMINE	-10	29	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		7281	3182	33	3H-MEPYRAMINE	-10	29	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		CHEMBL564	3182	33	3H-MEPYRAMINE	-10	29	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		DB00420	3182	33	3H-MEPYRAMINE	-10	29	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		100	3805	58	3H-MEPYRAMINE	-7	55	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	3805	58	3H-MEPYRAMINE	-7	55	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	3805	58	3H-MEPYRAMINE	-7	55	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	3805	58	3H-MEPYRAMINE	-7	55	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	3805	58	3H-MEPYRAMINE	-7	55	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		213	3853	55	3H-PYRILAMINE	-8	44	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		2717	3853	55	3H-PYRILAMINE	-8	44	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		5533	3853	55	3H-PYRILAMINE	-8	44	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		CHEMBL621	3853	55	3H-PYRILAMINE	-8	44	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		DB00656	3853	55	3H-PYRILAMINE	-8	44	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		1204	1932	119	3H-MEPYRAMINE	-501	24	Human	4.7	pKi	=	4.7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	3H-MEPYRAMINE	-501	24	Human	4.7	pKi	=	4.7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	3H-MEPYRAMINE	-501	24	Human	4.7	pKi	=	4.7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	3H-MEPYRAMINE	-501	24	Human	4.7	pKi	=	4.7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	3H-MEPYRAMINE	-501	24	Human	4.7	pKi	=	4.7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	3H-MEPYRAMINE	-501	24	Human	4.7	pKi	=	4.7	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		135398737	958	93	3H-PYRILAMINE	-2	89	Guinea pig	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		135398737	958	93	3H-MEPYRAMINE	-4	89	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-PYRILAMINE	-2	89	Guinea pig	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-MEPYRAMINE	-4	89	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-PYRILAMINE	-2	89	Guinea pig	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-MEPYRAMINE	-4	89	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-PYRILAMINE	-2	89	Guinea pig	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-MEPYRAMINE	-4	89	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-PYRILAMINE	-2	89	Guinea pig	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-MEPYRAMINE	-4	89	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		202	1508	77	3H-PYRILAMINE	-1	30	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		60835	1508	77	3H-PYRILAMINE	-1	30	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		972	1508	77	3H-PYRILAMINE	-1	30	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		CHEMBL1175	1508	77	3H-PYRILAMINE	-1	30	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		DB00476	1508	77	3H-PYRILAMINE	-1	30	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		135398737	958	93	3H-PYRILAMINE	-4	89	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-PYRILAMINE	-4	89	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-PYRILAMINE	-4	89	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-PYRILAMINE	-4	89	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-PYRILAMINE	-4	89	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		2181	3128	46	3H-PYRILAMINE	-269	35	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		4830	3128	46	3H-PYRILAMINE	-269	35	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		92	3128	46	3H-PYRILAMINE	-269	35	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		CHEMBL440294	3128	46	3H-PYRILAMINE	-269	35	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		DB09286	3128	46	3H-PYRILAMINE	-269	35	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		16362	3125	71	3H-PYRILAMINE	-489	30	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		2172	3125	71	3H-PYRILAMINE	-489	30	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		90	3125	71	3H-PYRILAMINE	-489	30	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		CHEMBL1423	3125	71	3H-PYRILAMINE	-489	30	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		DB01100	3125	71	3H-PYRILAMINE	-489	30	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		242	470	124	3H-PYRILAMINE	-22	51	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	470	124	3H-PYRILAMINE	-22	51	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	470	124	3H-PYRILAMINE	-22	51	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	470	124	3H-PYRILAMINE	-22	51	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	470	124	3H-PYRILAMINE	-22	51	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		4034	55822	55	3H-MEPYRAMINE	-	1	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	None
		CHEMBL1623	55822	55	3H-MEPYRAMINE	-	1	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	None
		2995	204405	53	3H-MEPYRAMINE	-12	23	Guinea pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		2995	204405	53	3H-MEPYRAMINE	-42	23	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL1696	204405	53	3H-MEPYRAMINE	-12	23	Guinea pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL1696	204405	53	3H-MEPYRAMINE	-42	23	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL72	204405	53	3H-MEPYRAMINE	-12	23	Guinea pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL72	204405	53	3H-MEPYRAMINE	-42	23	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		1353	1911	93	3H-MEPYRAMINE	-489	83	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-MEPYRAMINE	-489	83	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-MEPYRAMINE	-489	83	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-MEPYRAMINE	-489	83	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-MEPYRAMINE	-489	83	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1242	3613	27	3H-MEPYRAMINE	-147	18	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		935	3613	27	3H-MEPYRAMINE	-147	18	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		CHEMBL286080	3613	27	3H-MEPYRAMINE	-147	18	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		9906978	42711	2	UNDEFINED	-28	12	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	361	6	1	3	4.0	O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1	None
		CHEMBL150161	42711	2	UNDEFINED	-28	12	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	361	6	1	3	4.0	O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1	None
		2726	919	68	3H-MEPYRAMINE	-17	72	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	3H-MEPYRAMINE	-17	72	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	3H-MEPYRAMINE	-17	72	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	3H-MEPYRAMINE	-17	72	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	3H-MEPYRAMINE	-17	72	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		1427	2013	54	3H-MEPYRAMINE	-1	27	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		357	2013	54	3H-MEPYRAMINE	-1	27	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		3696	2013	54	3H-MEPYRAMINE	-1	27	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL11	2013	54	3H-MEPYRAMINE	-1	27	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		DB00458	2013	54	3H-MEPYRAMINE	-1	27	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		135398745	2914	112	3H-PYRILAMINE	-1	65	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-PYRILAMINE	-1	65	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-PYRILAMINE	-1	65	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-PYRILAMINE	-1	65	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		None	216924	0	UNDEFINED	-	1	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	333	5	1	4	3.5	COC1=C(C=CC(=C1)Cl)OC(C2CNCCO2)C3=CC=CC=C3	None
		1353	1911	93	3H-PYRILAMINE	-489	83	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-PYRILAMINE	-489	83	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-PYRILAMINE	-489	83	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-PYRILAMINE	-489	83	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-PYRILAMINE	-489	83	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		54477	84653	36	UNDEFINED	-70	23	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	None
		CHEMBL22242	84653	36	UNDEFINED	-70	23	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	None
		11848679	89244	0	UNDEFINED	-204	6	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	489	9	3	9	2.9	CCOc1cc(CN2CCC(Nc3nc4cc(S(N)(=O)=O)ccc4o3)CC2)cc(OCC)c1N	None
		CHEMBL236788	89244	0	UNDEFINED	-204	6	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	489	9	3	9	2.9	CCOc1cc(CN2CCC(Nc3nc4cc(S(N)(=O)=O)ccc4o3)CC2)cc(OCC)c1N	None
		24740863	89158	0	UNDEFINED	-3	6	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	385	6	1	5	5.0	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1Cl	None
		CHEMBL236610	89158	0	UNDEFINED	-3	6	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	385	6	1	5	5.0	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1Cl	None
		1170	1633	75	UNDEFINED	-	1	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	None
		3348	1633	75	UNDEFINED	-	1	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	None
		4819	1633	75	UNDEFINED	-	1	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	None
		74685737	1633	75	UNDEFINED	-	1	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	None
		CHEMBL914	1633	75	UNDEFINED	-	1	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	None
		DB00950	1633	75	UNDEFINED	-	1	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	None
		2389	3331	118	3H-PYRILAMINE	-46	67	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-PYRILAMINE	-46	67	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-PYRILAMINE	-46	67	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-PYRILAMINE	-46	67	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-PYRILAMINE	-46	67	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		11954259	215979	0	3H-MEPYRAMINE	-89	43	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
		2470	3653	50	3H-MEPYRAMINE	-81283	59	Guinea pig	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	3H-MEPYRAMINE	-81283	59	Guinea pig	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	3H-MEPYRAMINE	-81283	59	Guinea pig	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	3H-MEPYRAMINE	-81283	59	Guinea pig	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	3H-MEPYRAMINE	-81283	59	Guinea pig	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		4528	98126	80	3H-doxepin	-1	10	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	238	1	1	2	2.8	CN1Cc2c(N)cccc2C(c2ccccc2)C1	None
		CHEMBL273575	98126	80	3H-doxepin	-1	10	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	238	1	1	2	2.8	CN1Cc2c(N)cccc2C(c2ccccc2)C1	None
		1204	1932	119	3H-MEPYRAMINE	-46	24	Guinea pig	4.6	pKi	=	4.6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	3H-MEPYRAMINE	-46	24	Guinea pig	4.6	pKi	=	4.6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	3H-MEPYRAMINE	-46	24	Guinea pig	4.6	pKi	=	4.6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	3H-MEPYRAMINE	-46	24	Guinea pig	4.6	pKi	=	4.6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	3H-MEPYRAMINE	-46	24	Guinea pig	4.6	pKi	=	4.6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	3H-MEPYRAMINE	-46	24	Guinea pig	4.6	pKi	=	4.6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		2470	3653	50	3H-MEPYRAMINE	-4570	59	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	3H-MEPYRAMINE	-4570	59	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	3H-MEPYRAMINE	-4570	59	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	3H-MEPYRAMINE	-4570	59	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	3H-MEPYRAMINE	-4570	59	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		1223	953	41	3H-MEPYRAMINE	-14125	11	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		2790	953	41	3H-MEPYRAMINE	-14125	11	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		CHEMBL14690	953	41	3H-MEPYRAMINE	-14125	11	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		None	216100	0	3H-PYRILAMINE	-3	3	Guinea pig	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	485	10	1	8	3.0	CC(C1=NN(C(=O)N1CCOC2=CC=CC=C2)CCCN3CCN(CC3)C4=CC=C(C=C4)Cl)O	None
		2771	195017	74	3H-PYRILAMINE	-9	27	Guinea pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		2771	195017	74	3H-PYRILAMINE	-2	27	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL1200781	195017	74	3H-PYRILAMINE	-9	27	Guinea pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL1200781	195017	74	3H-PYRILAMINE	-2	27	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL549	195017	74	3H-PYRILAMINE	-9	27	Guinea pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL549	195017	74	3H-PYRILAMINE	-2	27	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		242	470	124	3H-PYRILAMINE	-22	51	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	470	124	3H-PYRILAMINE	-22	51	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	470	124	3H-PYRILAMINE	-22	51	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	470	124	3H-PYRILAMINE	-22	51	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	470	124	3H-PYRILAMINE	-22	51	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		213	3853	55	3H-PYRILAMINE	-2	44	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		2717	3853	55	3H-PYRILAMINE	-2	44	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		5533	3853	55	3H-PYRILAMINE	-2	44	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		CHEMBL621	3853	55	3H-PYRILAMINE	-2	44	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		DB00656	3853	55	3H-PYRILAMINE	-2	44	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		444	206666	53	3H-PYRILAMINE	-6	18	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	239	3	1	2	3.3	CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1	None
		CHEMBL894	206666	53	3H-PYRILAMINE	-6	18	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	239	3	1	2	3.3	CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1	None
		242	470	124	3H-PYRILAMINE	-22	51	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	470	124	3H-PYRILAMINE	-22	51	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	470	124	3H-PYRILAMINE	-22	51	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	470	124	3H-PYRILAMINE	-22	51	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	470	124	3H-PYRILAMINE	-22	51	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		1353	1911	93	3H-PYRILAMINE	-602	83	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-PYRILAMINE	-602	83	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-PYRILAMINE	-602	83	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-PYRILAMINE	-602	83	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-PYRILAMINE	-602	83	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		None	217161	0	UNDEFINED	-190	6	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	532	10	0	4	8.0	CN(CCC=C1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl)CC4=CC=C(C=C4)OCCCN5CCCCC5	None
		2402	3370	62	3H-PYRILAMINE	-194	24	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		5095	3370	62	3H-PYRILAMINE	-194	24	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		7295	3370	62	3H-PYRILAMINE	-194	24	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		CHEMBL589	3370	62	3H-PYRILAMINE	-194	24	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		DB00268	3370	62	3H-PYRILAMINE	-194	24	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		1210	918	51	3H-MEPYRAMINE	-20	21	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		1213	918	51	3H-MEPYRAMINE	-20	21	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		2725	918	51	3H-MEPYRAMINE	-20	21	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		33036	918	51	3H-MEPYRAMINE	-20	21	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		4411	918	51	3H-MEPYRAMINE	-20	21	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		616	918	51	3H-MEPYRAMINE	-20	21	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		6976	918	51	3H-MEPYRAMINE	-20	21	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		716121	918	51	3H-MEPYRAMINE	-20	21	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL1201353	918	51	3H-MEPYRAMINE	-20	21	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL1554789	918	51	3H-MEPYRAMINE	-20	21	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL505	918	51	3H-MEPYRAMINE	-20	21	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		DB01114	918	51	3H-MEPYRAMINE	-20	21	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		DB13679	918	51	3H-MEPYRAMINE	-20	21	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		2726	919	68	3H-doxepin	-2	72	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	3H-doxepin	-2	72	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	3H-doxepin	-2	72	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	3H-doxepin	-2	72	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	3H-doxepin	-2	72	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		1228	3866	34	3H-MEPYRAMINE	-5	4	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		2763	3866	34	3H-MEPYRAMINE	-5	4	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		5282443	3866	34	3H-MEPYRAMINE	-5	4	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		CHEMBL855	3866	34	3H-MEPYRAMINE	-5	4	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		DB00427	3866	34	3H-MEPYRAMINE	-5	4	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		135398737	958	93	3H-PYRILAMINE	2	89	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-PYRILAMINE	2	89	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-PYRILAMINE	2	89	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-PYRILAMINE	2	89	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-PYRILAMINE	2	89	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		277	1301	62	3H-MEPYRAMINE	-3	50	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	1301	62	3H-MEPYRAMINE	-3	50	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	1301	62	3H-MEPYRAMINE	-3	50	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	1301	62	3H-MEPYRAMINE	-3	50	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	1301	62	3H-MEPYRAMINE	-3	50	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		3103	41658	49	3H-MEPYRAMINE	1	4	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	281	4	0	2	3.9	CN1CCC(OC(c2ccccc2)c2ccccc2)CC1	None
		CHEMBL1492	41658	49	3H-MEPYRAMINE	1	4	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	281	4	0	2	3.9	CN1CCC(OC(c2ccccc2)c2ccccc2)CC1	None
		1222	881	0	3H-MEPYRAMINE	-1	2	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		2678	881	0	3H-MEPYRAMINE	-1	2	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		581	881	0	3H-MEPYRAMINE	-1	2	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		CHEMBL1000	881	0	3H-MEPYRAMINE	-1	2	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		DB00341	881	0	3H-MEPYRAMINE	-1	2	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		2600	3779	74	3H-MEPYRAMINE	1	13	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		2608	3779	74	3H-MEPYRAMINE	1	13	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		5405	3779	74	3H-MEPYRAMINE	1	13	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		CHEMBL17157	3779	74	3H-MEPYRAMINE	1	13	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		DB00342	3779	74	3H-MEPYRAMINE	1	13	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		1227	2489	43	3H-MEPYRAMINE	-3	12	Mouse	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		2331	2489	43	3H-MEPYRAMINE	-3	12	Mouse	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		3957	2489	43	3H-MEPYRAMINE	-3	12	Mouse	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		4992	2489	43	3H-MEPYRAMINE	-3	12	Mouse	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		CHEMBL511	2489	43	3H-MEPYRAMINE	-3	12	Mouse	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		DB06691	2489	43	3H-MEPYRAMINE	-3	12	Mouse	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		2286	3183	51	3H-MEPYRAMINE	-1	30	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		4927	3183	51	3H-MEPYRAMINE	-1	30	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		7282	3183	51	3H-MEPYRAMINE	-1	30	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		CHEMBL643	3183	51	3H-MEPYRAMINE	-1	30	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		DB01069	3183	51	3H-MEPYRAMINE	-1	30	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		3103	41658	49	3H-MEPYRAMINE	-1	4	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	281	4	0	2	3.9	CN1CCC(OC(c2ccccc2)c2ccccc2)CC1	None
		CHEMBL1492	41658	49	3H-MEPYRAMINE	-1	4	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	281	4	0	2	3.9	CN1CCC(OC(c2ccccc2)c2ccccc2)CC1	None
		55482	216150	0	3H-MEPYRAMINE	-	1	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	441	8	2	5	4.0	CC1=NC=C(C=C1)CC2=CN=C(NC2=O)NCCCCC3=NC=C(C=C3C)Br	None
		103	4153	61	3H-PYRILAMINE	-1	53	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	4153	61	3H-PYRILAMINE	-1	53	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	4153	61	3H-PYRILAMINE	-1	53	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	4153	61	3H-PYRILAMINE	-1	53	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	4153	61	3H-PYRILAMINE	-1	53	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		135409468	2035	69	3H-PYRILAMINE	-1	39	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		333	2035	69	3H-PYRILAMINE	-1	39	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		CHEMBL845	2035	69	3H-PYRILAMINE	-1	39	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		103	4153	61	3H-PYRILAMINE	-2	53	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	4153	61	3H-PYRILAMINE	-2	53	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	4153	61	3H-PYRILAMINE	-2	53	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	4153	61	3H-PYRILAMINE	-2	53	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	4153	61	3H-PYRILAMINE	-2	53	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		115237	55585	119	3H-PYRILAMINE	-36	54	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		CHEMBL1621	55585	119	3H-PYRILAMINE	-36	54	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		135398745	2914	112	3H-PYRILAMINE	-2	65	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-PYRILAMINE	-2	65	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-PYRILAMINE	-2	65	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-PYRILAMINE	-2	65	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		1227	2489	43	3H-MEPYRAMINE	-2	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		2331	2489	43	3H-MEPYRAMINE	-2	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		3957	2489	43	3H-MEPYRAMINE	-2	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		4992	2489	43	3H-MEPYRAMINE	-2	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		CHEMBL511	2489	43	3H-MEPYRAMINE	-2	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		DB06691	2489	43	3H-MEPYRAMINE	-2	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		1228	3866	34	3H-MEPYRAMINE	-5	4	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		2763	3866	34	3H-MEPYRAMINE	-5	4	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		5282443	3866	34	3H-MEPYRAMINE	-5	4	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		CHEMBL855	3866	34	3H-MEPYRAMINE	-5	4	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		DB00427	3866	34	3H-MEPYRAMINE	-5	4	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		11976	920	59	UNDEFINED	-4	24	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		667467	920	59	UNDEFINED	-4	24	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		CHEMBL908	920	59	UNDEFINED	-4	24	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		DB01239	920	59	UNDEFINED	-4	24	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		1227	2489	43	3H-MEPYRAMINE	-2	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		2331	2489	43	3H-MEPYRAMINE	-2	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		3957	2489	43	3H-MEPYRAMINE	-2	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		4992	2489	43	3H-MEPYRAMINE	-2	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		CHEMBL511	2489	43	3H-MEPYRAMINE	-2	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		DB06691	2489	43	3H-MEPYRAMINE	-2	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		1227	2489	43	3H-MEPYRAMINE	-2	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		2331	2489	43	3H-MEPYRAMINE	-2	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		3957	2489	43	3H-MEPYRAMINE	-2	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		4992	2489	43	3H-MEPYRAMINE	-2	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		CHEMBL511	2489	43	3H-MEPYRAMINE	-2	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		DB06691	2489	43	3H-MEPYRAMINE	-2	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		1890	2759	49	3H-PYRILAMINE	-4	16	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
		4449	2759	49	3H-PYRILAMINE	-4	16	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
		7247	2759	49	3H-PYRILAMINE	-4	16	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
		CHEMBL623	2759	49	3H-PYRILAMINE	-4	16	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
		DB01149	2759	49	3H-PYRILAMINE	-4	16	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
		1971	2866	38	3H-MEPYRAMINE	-6	30	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		2404	2866	38	3H-MEPYRAMINE	-6	30	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		4543	2866	38	3H-MEPYRAMINE	-6	30	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		CHEMBL445	2866	38	3H-MEPYRAMINE	-6	30	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		DB00540	2866	38	3H-MEPYRAMINE	-6	30	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		2284	3182	33	3H-MEPYRAMINE	-10	29	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		4926	3182	33	3H-MEPYRAMINE	-10	29	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		7281	3182	33	3H-MEPYRAMINE	-10	29	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		CHEMBL564	3182	33	3H-MEPYRAMINE	-10	29	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		DB00420	3182	33	3H-MEPYRAMINE	-10	29	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		90475904	216022	0	3H-doxepin	-7	6	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(C)CCC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2	None
		134	2514	24	3H-MEPYRAMINE	-2570	67	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		134	2514	24	3H-MEPYRAMINE	-933	67	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	3H-MEPYRAMINE	-2570	67	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	3H-MEPYRAMINE	-933	67	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	3H-MEPYRAMINE	-2570	67	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	3H-MEPYRAMINE	-933	67	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	3H-MEPYRAMINE	-2570	67	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	3H-MEPYRAMINE	-933	67	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	3H-MEPYRAMINE	-2570	67	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	3H-MEPYRAMINE	-933	67	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1353	1911	93	3H-PYRILAMINE	-489	83	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-PYRILAMINE	-489	83	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-PYRILAMINE	-489	83	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-PYRILAMINE	-489	83	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-PYRILAMINE	-489	83	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		125564	666	97	3H-PYRILAMINE	-5248	7	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	367	3	0	3	4.7	CCN1CCN(CC1)c1nc2CCCCCCc2c(c1)c1ccc(cc1)F	None
		388	666	97	3H-PYRILAMINE	-5248	7	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	367	3	0	3	4.7	CCN1CCN(CC1)c1nc2CCCCCCc2c(c1)c1ccc(cc1)F	None
		7670	666	97	3H-PYRILAMINE	-5248	7	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	367	3	0	3	4.7	CCN1CCN(CC1)c1nc2CCCCCCc2c(c1)c1ccc(cc1)F	None
		CHEMBL178803	666	97	3H-PYRILAMINE	-5248	7	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	367	3	0	3	4.7	CCN1CCN(CC1)c1nc2CCCCCCc2c(c1)c1ccc(cc1)F	None
		DB09223	666	97	3H-PYRILAMINE	-5248	7	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	367	3	0	3	4.7	CCN1CCN(CC1)c1nc2CCCCCCc2c(c1)c1ccc(cc1)F	None
		1427	2013	54	3H-Histamine	-1	27	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		357	2013	54	3H-Histamine	-1	27	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		3696	2013	54	3H-Histamine	-1	27	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL11	2013	54	3H-Histamine	-1	27	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		DB00458	2013	54	3H-Histamine	-1	27	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		2995	204405	53	3H-PYRILAMINE	-12	23	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		2995	204405	53	3H-PYRILAMINE	-14	23	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL1696	204405	53	3H-PYRILAMINE	-12	23	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL1696	204405	53	3H-PYRILAMINE	-14	23	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL72	204405	53	3H-PYRILAMINE	-12	23	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL72	204405	53	3H-PYRILAMINE	-14	23	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		37459	746	13	3H-MEPYRAMINE	-7244	25	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		62	746	13	3H-MEPYRAMINE	-7244	25	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		CHEMBL8514	746	13	3H-MEPYRAMINE	-7244	25	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		40589	216144	0	3H-PYRILAMINE	-5	8	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	377	7	0	6	2.5	CCC1=NN(C(=O)N1CC)CCCN2CCN(CC2)C3=CC(=CC=C3)Cl	None
		1204	1932	119	3H-MEPYRAMINE	-46	24	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	3H-MEPYRAMINE	-46	24	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	3H-MEPYRAMINE	-46	24	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	3H-MEPYRAMINE	-46	24	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	3H-MEPYRAMINE	-46	24	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	3H-MEPYRAMINE	-46	24	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		115237	55585	119	3H-PYRILAMINE	-36	54	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		CHEMBL1621	55585	119	3H-PYRILAMINE	-36	54	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		2435	3590	83	3H-PYRILAMINE	-95	48	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		60149	3590	83	3H-PYRILAMINE	-95	48	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		98	3590	83	3H-PYRILAMINE	-95	48	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		CHEMBL12713	3590	83	3H-PYRILAMINE	-95	48	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		DB06144	3590	83	3H-PYRILAMINE	-95	48	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		1209	1658	75	3H-MEPYRAMINE	-602	32	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		203	1658	75	3H-MEPYRAMINE	-602	32	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		3386	1658	75	3H-MEPYRAMINE	-602	32	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		CHEMBL41	1658	75	3H-MEPYRAMINE	-602	32	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		DB00472	1658	75	3H-MEPYRAMINE	-602	32	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		108107	79944	38	3H-MEPYRAMINE	-5	16	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	319	3	4	5	0.5	N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1	None
		156592250	79944	38	3H-MEPYRAMINE	-5	16	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	319	3	4	5	0.5	N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1	None
		CHEMBL1256878	79944	38	3H-MEPYRAMINE	-5	16	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	319	3	4	5	0.5	N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1	None
		CHEMBL212579	79944	38	3H-MEPYRAMINE	-5	16	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	319	3	4	5	0.5	N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1	None
		45485498	197671	0	UNDEFINED	-	1	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	231	5	0	1	3.8	Cc1ccc(CCCCN2CCCCC2)cc1	None
		CHEMBL571073	197671	0	UNDEFINED	-	1	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	231	5	0	1	3.8	Cc1ccc(CCCCN2CCCCC2)cc1	None
		7153	98020	77	3H-PYRILAMINE	-16	34	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		CHEMBL272942	98020	77	3H-PYRILAMINE	-16	34	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		2389	3331	118	3H-PYRILAMINE	-46	67	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-PYRILAMINE	-46	67	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-PYRILAMINE	-46	67	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-PYRILAMINE	-46	67	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-PYRILAMINE	-46	67	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		1221	475	9	3H-MEPYRAMINE	2	3	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	380	9	3	3	3.0	NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)F	None
		65895	475	9	3H-MEPYRAMINE	2	3	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	380	9	3	3	3.0	NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)F	None
		CHEMBL293802	475	9	3H-MEPYRAMINE	2	3	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	380	9	3	3	3.0	NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)F	None
		1353	1911	93	3H-MEPYRAMINE	-602	83	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-MEPYRAMINE	-602	83	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-MEPYRAMINE	-602	83	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-MEPYRAMINE	-602	83	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-MEPYRAMINE	-602	83	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		2142	3096	58	3H-MEPYRAMINE	-1258	36	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4920903	3096	58	3H-MEPYRAMINE	-1258	36	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		502	3096	58	3H-MEPYRAMINE	-1258	36	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		5775	3096	58	3H-MEPYRAMINE	-1258	36	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		CHEMBL597	3096	58	3H-MEPYRAMINE	-1258	36	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		DB00692	3096	58	3H-MEPYRAMINE	-1258	36	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		134	2514	24	3H-MEPYRAMINE	-15488	67	Rat	4.5	pKi	=	4.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	3H-MEPYRAMINE	-15488	67	Rat	4.5	pKi	=	4.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	3H-MEPYRAMINE	-15488	67	Rat	4.5	pKi	=	4.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	3H-MEPYRAMINE	-15488	67	Rat	4.5	pKi	=	4.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	3H-MEPYRAMINE	-15488	67	Rat	4.5	pKi	=	4.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		2601	3780	33	3H-PYRILAMINE	-389	21	Guinea pig	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		443951	3780	33	3H-PYRILAMINE	-389	21	Guinea pig	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		56	3780	33	3H-PYRILAMINE	-389	21	Guinea pig	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL73151	3780	33	3H-PYRILAMINE	-389	21	Guinea pig	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB13399	3780	33	3H-PYRILAMINE	-389	21	Guinea pig	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		100	3805	58	3H-MEPYRAMINE	-16	55	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	3805	58	3H-MEPYRAMINE	-16	55	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	3805	58	3H-MEPYRAMINE	-16	55	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	3805	58	3H-MEPYRAMINE	-16	55	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	3805	58	3H-MEPYRAMINE	-16	55	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		1588	2325	27	3H-PYRILAMINE	-100	44	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		28864	2325	27	3H-PYRILAMINE	-100	44	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		43	2325	27	3H-PYRILAMINE	-100	44	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL157138	2325	27	3H-PYRILAMINE	-100	44	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB00589	2325	27	3H-PYRILAMINE	-100	44	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		2762	3863	31	3H-MEPYRAMINE	9	2	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	None
		5587	3863	31	3H-MEPYRAMINE	9	2	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	None
		7318	3863	31	3H-MEPYRAMINE	9	2	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	None
		CHEMBL1241	3863	31	3H-MEPYRAMINE	9	2	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	None
		DB00792	3863	31	3H-MEPYRAMINE	9	2	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	None
		4528	98126	80	3H-PYRILAMINE	-7	10	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	238	1	1	2	2.8	CN1Cc2c(N)cccc2C(c2ccccc2)C1	None
		CHEMBL273575	98126	80	3H-PYRILAMINE	-7	10	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	238	1	1	2	2.8	CN1Cc2c(N)cccc2C(c2ccccc2)C1	None
		2771	195017	74	3H-MEPYRAMINE	-6	27	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL1200781	195017	74	3H-MEPYRAMINE	-6	27	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL549	195017	74	3H-MEPYRAMINE	-6	27	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		1221	475	9	3H-MEPYRAMINE	-12	3	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	380	9	3	3	3.0	NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)F	None
		65895	475	9	3H-MEPYRAMINE	-12	3	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	380	9	3	3	3.0	NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)F	None
		CHEMBL293802	475	9	3H-MEPYRAMINE	-12	3	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	380	9	3	3	3.0	NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)F	None
		2726	919	68	3H-MEPYRAMINE	-17	72	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	3H-MEPYRAMINE	-17	72	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	3H-MEPYRAMINE	-17	72	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	3H-MEPYRAMINE	-17	72	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	3H-MEPYRAMINE	-17	72	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		135398737	958	93	3H-MEPYRAMINE	-4	89	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-MEPYRAMINE	-4	89	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-MEPYRAMINE	-4	89	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-MEPYRAMINE	-4	89	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-MEPYRAMINE	-4	89	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		3947	206395	53	3H-PYRILAMINE	-7	16	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	None
		CHEMBL87708	206395	53	3H-PYRILAMINE	-7	16	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	None
		11848625	5792	0	UNDEFINED	-38	6	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	451	8	1	7	4.9	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)cc(OC2CCOCC2)c1	None
		CHEMBL1078745	5792	0	UNDEFINED	-38	6	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	451	8	1	7	4.9	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)cc(OC2CCOCC2)c1	None
		16667681	216153	0	3H-MEPYRAMINE	4	3	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	390	7	1	5	3.5	CN(C)CCCC1=CC=CC=N1.C1=CC(=CC=C1OC(=O)C=CC(=O)O)Cl	None
		1353	1911	93	3H-PYRILAMINE	-602	83	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-PYRILAMINE	-602	83	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-PYRILAMINE	-602	83	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-PYRILAMINE	-602	83	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-PYRILAMINE	-602	83	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1427	2013	54	3H-PYRILAMINE	-5	27	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		357	2013	54	3H-PYRILAMINE	-5	27	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		3696	2013	54	3H-PYRILAMINE	-5	27	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL11	2013	54	3H-PYRILAMINE	-5	27	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		DB00458	2013	54	3H-PYRILAMINE	-5	27	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		1890	2759	49	3H-PYRILAMINE	-44	16	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
		1890	2759	49	3H-MEPYRAMINE	-57	16	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
		4449	2759	49	3H-PYRILAMINE	-44	16	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
		4449	2759	49	3H-MEPYRAMINE	-57	16	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
		7247	2759	49	3H-PYRILAMINE	-44	16	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
		7247	2759	49	3H-MEPYRAMINE	-57	16	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
		CHEMBL623	2759	49	3H-PYRILAMINE	-44	16	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
		CHEMBL623	2759	49	3H-MEPYRAMINE	-57	16	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
		DB01149	2759	49	3H-PYRILAMINE	-44	16	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
		DB01149	2759	49	3H-MEPYRAMINE	-57	16	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
		1353	1911	93	3H-pirilamine	-602	83	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-pirilamine	-602	83	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-pirilamine	-602	83	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-pirilamine	-602	83	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-pirilamine	-602	83	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		6852400	215937	0	UNDEFINED	-977	22	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
		73759726	215937	0	UNDEFINED	-977	22	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
		44622872	197716	0	UNDEFINED	-	1	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	413	8	1	2	6.0	Cc1ccc(CCCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1	None
		CHEMBL571389	197716	0	UNDEFINED	-	1	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	413	8	1	2	6.0	Cc1ccc(CCCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1	None
		25212275	174421	0	UNDEFINED	-9332	6	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	682	13	0	8	7.4	O=C(OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1)c1ccc(OCCCN2CCCCC2)cc1	None
		CHEMBL455288	174421	0	UNDEFINED	-9332	6	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	682	13	0	8	7.4	O=C(OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1)c1ccc(OCCCN2CCCCC2)cc1	None
		6852400	215937	0	3H-doxepin	-977	22	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
		73759726	215937	0	3H-doxepin	-977	22	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
		3025067	99382	64	3H-MEPYRAMINE	-199	15	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	220	1	1	4	0.9	c1cc2c(c(N3CCNCC3)c1)OCCO2	None
		65853	99382	64	3H-MEPYRAMINE	-199	15	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	220	1	1	4	0.9	c1cc2c(c(N3CCNCC3)c1)OCCO2	None
		CHEMBL282614	99382	64	3H-MEPYRAMINE	-199	15	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	220	1	1	4	0.9	c1cc2c(c(N3CCNCC3)c1)OCCO2	None
		1613	2348	53	3H-Histamine	-3	44	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	2348	53	3H-Histamine	-3	44	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	2348	53	3H-Histamine	-3	44	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	2348	53	3H-Histamine	-3	44	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	2348	53	3H-Histamine	-3	44	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		135398737	958	93	3H-MEPYRAMINE	-2	89	Guinea pig	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-MEPYRAMINE	-2	89	Guinea pig	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-MEPYRAMINE	-2	89	Guinea pig	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-MEPYRAMINE	-2	89	Guinea pig	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-MEPYRAMINE	-2	89	Guinea pig	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		1227	2489	43	3H-doxepin	-2	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		2331	2489	43	3H-doxepin	-2	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		3957	2489	43	3H-doxepin	-2	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		4992	2489	43	3H-doxepin	-2	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		CHEMBL511	2489	43	3H-doxepin	-2	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		DB06691	2489	43	3H-doxepin	-2	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		2286	3183	51	3H-PYRILAMINE	-1	30	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		4927	3183	51	3H-PYRILAMINE	-1	30	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		7282	3183	51	3H-PYRILAMINE	-1	30	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		CHEMBL643	3183	51	3H-PYRILAMINE	-1	30	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		DB01069	3183	51	3H-PYRILAMINE	-1	30	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		11954259	215979	0	3H-PYRILAMINE	-19	43	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
		20980871	216430	0	3H-MEPYRAMINE	4	8	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	295	3	0	2	4.7	CN(C)CCC=C1C2=CC=CC=C2CSC3=CC=CC=C31	None
		135	2532	43	3H-MEPYRAMINE	1	58	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-MEPYRAMINE	1	58	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-MEPYRAMINE	1	58	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-MEPYRAMINE	1	58	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-MEPYRAMINE	1	58	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1204	1932	119	None	-501	24	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]mepyramine from human wild-type histamine H1 receptor expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human wild-type histamine H1 receptor expressed in COS-7 cells by liquid scintillation counting	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	None	-501	24	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]mepyramine from human wild-type histamine H1 receptor expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human wild-type histamine H1 receptor expressed in COS-7 cells by liquid scintillation counting	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	None	-501	24	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]mepyramine from human wild-type histamine H1 receptor expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human wild-type histamine H1 receptor expressed in COS-7 cells by liquid scintillation counting	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	None	-501	24	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]mepyramine from human wild-type histamine H1 receptor expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human wild-type histamine H1 receptor expressed in COS-7 cells by liquid scintillation counting	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	None	-501	24	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]mepyramine from human wild-type histamine H1 receptor expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human wild-type histamine H1 receptor expressed in COS-7 cells by liquid scintillation counting	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	None	-501	24	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]mepyramine from human wild-type histamine H1 receptor expressed in COS-7 cells by liquid scintillation countingDisplacement of [3H]mepyramine from human wild-type histamine H1 receptor expressed in COS-7 cells by liquid scintillation counting	Drug Central	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		180	401	56	3H-MEPYRAMINE	-11	40	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		200	401	56	3H-MEPYRAMINE	-11	40	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2160	401	56	3H-MEPYRAMINE	-11	40	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL629	401	56	3H-MEPYRAMINE	-11	40	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		DB00321	401	56	3H-MEPYRAMINE	-11	40	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2554	796	119	None	1	8	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	None
		489	796	119	None	1	8	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	None
		5339	796	119	None	1	8	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	None
		CHEMBL108	796	119	None	1	8	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	None
		DB00564	796	119	None	1	8	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	None
		135	2532	43	3H-PYRILAMINE	-1	58	Guinea pig	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-PYRILAMINE	-1	58	Guinea pig	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-PYRILAMINE	-1	58	Guinea pig	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-PYRILAMINE	-1	58	Guinea pig	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-PYRILAMINE	-1	58	Guinea pig	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		2284	3182	33	3H-MEPYRAMINE	1	29	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		4926	3182	33	3H-MEPYRAMINE	1	29	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		7281	3182	33	3H-MEPYRAMINE	1	29	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		CHEMBL564	3182	33	3H-MEPYRAMINE	1	29	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		DB00420	3182	33	3H-MEPYRAMINE	1	29	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		2726	919	68	UNDEFINED	-2	72	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	UNDEFINED	-2	72	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	UNDEFINED	-2	72	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	UNDEFINED	-2	72	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	UNDEFINED	-2	72	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		135398745	2914	112	3H-pirilamine	-1	65	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-pirilamine	-1	65	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-pirilamine	-1	65	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-pirilamine	-1	65	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		11954259	215979	0	3H-doxepin	-19	43	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
		2726	919	68	3H-MEPYRAMINE	-6	72	Guinea pig	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	3H-MEPYRAMINE	-6	72	Guinea pig	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	3H-MEPYRAMINE	-6	72	Guinea pig	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	3H-MEPYRAMINE	-6	72	Guinea pig	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	3H-MEPYRAMINE	-6	72	Guinea pig	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		1227	2489	43	3H-MEPYRAMINE	-5	12	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		2331	2489	43	3H-MEPYRAMINE	-5	12	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		3957	2489	43	3H-MEPYRAMINE	-5	12	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		4992	2489	43	3H-MEPYRAMINE	-5	12	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		CHEMBL511	2489	43	3H-MEPYRAMINE	-5	12	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		DB06691	2489	43	3H-MEPYRAMINE	-5	12	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		4098	32505	30	3H-MEPYRAMINE	-1	11	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	None
		CHEMBL1255739	32505	30	3H-MEPYRAMINE	-1	11	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	None
		CHEMBL1411979	32505	30	3H-MEPYRAMINE	-1	11	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	None
		2865	4143	73	3H-PYRILAMINE	-58	53	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	4143	73	3H-PYRILAMINE	-58	53	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	4143	73	3H-PYRILAMINE	-58	53	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	4143	73	3H-PYRILAMINE	-58	53	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	4143	73	3H-PYRILAMINE	-58	53	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		2303	3187	68	None	-363	26	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		4946	3187	68	None	-363	26	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		564	3187	68	None	-363	26	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		63	3187	68	None	-363	26	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		91536	3187	68	None	-363	26	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		CHEMBL27	3187	68	None	-363	26	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		CHEMBL452861	3187	68	None	-363	26	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		DB00571	3187	68	None	-363	26	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		1227	2489	43	3H-MEPYRAMINE	-2	12	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		2331	2489	43	3H-MEPYRAMINE	-2	12	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		3957	2489	43	3H-MEPYRAMINE	-2	12	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		4992	2489	43	3H-MEPYRAMINE	-2	12	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		CHEMBL511	2489	43	3H-MEPYRAMINE	-2	12	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		DB06691	2489	43	3H-MEPYRAMINE	-2	12	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		6834	205552	45	3H-MEPYRAMINE	1	2	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	318	5	0	2	3.9	CN(C)CCC(c1ccc(Br)cc1)c1ccccn1	None
		CHEMBL811	205552	45	3H-MEPYRAMINE	1	2	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	318	5	0	2	3.9	CN(C)CCC(c1ccc(Br)cc1)c1ccccn1	None
		3103	41658	49	3H-MEPYRAMINE	-1	4	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	281	4	0	2	3.9	CN1CCC(OC(c2ccccc2)c2ccccc2)CC1	None
		CHEMBL1492	41658	49	3H-MEPYRAMINE	-1	4	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	281	4	0	2	3.9	CN1CCC(OC(c2ccccc2)c2ccccc2)CC1	None
		90475904	216022	0	3H-MEPYRAMINE	-7	6	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(C)CCC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2	None
		1613	2348	53	3H-doxepin	-3	44	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	2348	53	3H-doxepin	-3	44	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	2348	53	3H-doxepin	-3	44	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	2348	53	3H-doxepin	-3	44	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	2348	53	3H-doxepin	-3	44	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		135398745	2914	112	3H-PYRILAMINE	1	65	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-PYRILAMINE	1	65	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-PYRILAMINE	1	65	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-PYRILAMINE	1	65	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		2564	206184	51	3H-MEPYRAMINE	-2	3	Guinea pig	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	290	6	0	3	3.4	CN(C)CCOC(c1ccc(Cl)cc1)c1ccccn1	None
		CHEMBL864	206184	51	3H-MEPYRAMINE	-2	3	Guinea pig	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	290	6	0	3	3.4	CN(C)CCOC(c1ccc(Cl)cc1)c1ccccn1	None
		1212	1662	50	UNDEFINED	-41	65	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	1662	50	UNDEFINED	-41	65	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	1662	50	UNDEFINED	-41	65	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	1662	50	UNDEFINED	-41	65	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	1662	50	UNDEFINED	-41	65	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2600	3779	74	UNDEFINED	1	13	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		2608	3779	74	UNDEFINED	1	13	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		5405	3779	74	UNDEFINED	1	13	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		CHEMBL17157	3779	74	UNDEFINED	1	13	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		DB00342	3779	74	UNDEFINED	1	13	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		25212276	190066	0	UNDEFINED	-112	6	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	508	11	0	3	7.4	CN(CCCC12CCC(c3ccccc31)c1ccccc12)Cc1ccc(OCCCN2CCCCC2)cc1	None
		CHEMBL517244	190066	0	UNDEFINED	-112	6	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	508	11	0	3	7.4	CN(CCCC12CCC(c3ccccc31)c1ccccc12)Cc1ccc(OCCCN2CCCCC2)cc1	None
		2142	3096	58	3H-doxepin	-263	36	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4920903	3096	58	3H-doxepin	-263	36	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		502	3096	58	3H-doxepin	-263	36	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		5775	3096	58	3H-doxepin	-263	36	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		CHEMBL597	3096	58	3H-doxepin	-263	36	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		DB00692	3096	58	3H-doxepin	-263	36	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		1204	1932	119	3H-MEPYRAMINE	-309	24	Rat	4.4	pKi	=	4.4	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	3H-MEPYRAMINE	-309	24	Rat	4.4	pKi	=	4.4	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	3H-MEPYRAMINE	-309	24	Rat	4.4	pKi	=	4.4	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	3H-MEPYRAMINE	-309	24	Rat	4.4	pKi	=	4.4	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	3H-MEPYRAMINE	-309	24	Rat	4.4	pKi	=	4.4	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	3H-MEPYRAMINE	-309	24	Rat	4.4	pKi	=	4.4	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		2142	3096	58	3H-MEPYRAMINE	-7585	36	Rat	4.4	pKi	=	4.4	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4920903	3096	58	3H-MEPYRAMINE	-7585	36	Rat	4.4	pKi	=	4.4	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		502	3096	58	3H-MEPYRAMINE	-7585	36	Rat	4.4	pKi	=	4.4	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		5775	3096	58	3H-MEPYRAMINE	-7585	36	Rat	4.4	pKi	=	4.4	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		CHEMBL597	3096	58	3H-MEPYRAMINE	-7585	36	Rat	4.4	pKi	=	4.4	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		DB00692	3096	58	3H-MEPYRAMINE	-7585	36	Rat	4.4	pKi	=	4.4	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		37459	746	13	3H-MEPYRAMINE	-1174	25	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		62	746	13	3H-MEPYRAMINE	-1174	25	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		CHEMBL8514	746	13	3H-MEPYRAMINE	-1174	25	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		135398737	958	93	3H-MEPYRAMINE	-4	89	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-MEPYRAMINE	-4	89	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-MEPYRAMINE	-4	89	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-MEPYRAMINE	-4	89	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-MEPYRAMINE	-4	89	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		1353	1911	93	3H-PYRILAMINE	-489	83	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-PYRILAMINE	-489	83	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-PYRILAMINE	-489	83	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-PYRILAMINE	-489	83	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-PYRILAMINE	-489	83	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3012003	216145	0	3H-PYRILAMINE	-6	12	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	311	5	0	3	3.8	CN1CCC(C(C1)COC2=CC=C(C=C2)OC)C3=CC=CC=C3	None
		2865	4143	73	3H-PYRILAMINE	-58	53	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	4143	73	3H-PYRILAMINE	-58	53	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	4143	73	3H-PYRILAMINE	-58	53	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	4143	73	3H-PYRILAMINE	-58	53	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	4143	73	3H-PYRILAMINE	-58	53	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		3294	2006	111	3H-PYRILAMINE	-630	45	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		71360	2006	111	3H-PYRILAMINE	-630	45	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		87	2006	111	3H-PYRILAMINE	-630	45	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		CHEMBL14376	2006	111	3H-PYRILAMINE	-630	45	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		DB04946	2006	111	3H-PYRILAMINE	-630	45	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		1353	1911	93	3H-PYRILAMINE	-489	83	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-PYRILAMINE	-489	83	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-PYRILAMINE	-489	83	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-PYRILAMINE	-489	83	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-PYRILAMINE	-489	83	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1353	1911	93	UNDEFINED	-489	83	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	UNDEFINED	-489	83	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	UNDEFINED	-489	83	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	UNDEFINED	-489	83	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	UNDEFINED	-489	83	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		2435	3590	83	UNDEFINED	-851	48	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		60149	3590	83	UNDEFINED	-851	48	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		98	3590	83	UNDEFINED	-851	48	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		CHEMBL12713	3590	83	UNDEFINED	-851	48	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		DB06144	3590	83	UNDEFINED	-851	48	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		7153	98020	77	3H-PYRILAMINE	-23	34	Guinea pig	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		CHEMBL272942	98020	77	3H-PYRILAMINE	-23	34	Guinea pig	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		2995	204405	53	3H-MEPYRAMINE	-14	23	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL1696	204405	53	3H-MEPYRAMINE	-14	23	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL72	204405	53	3H-MEPYRAMINE	-14	23	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		1971	2866	38	3H-MEPYRAMINE	-9	30	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		2404	2866	38	3H-MEPYRAMINE	-9	30	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		4543	2866	38	3H-MEPYRAMINE	-9	30	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		CHEMBL445	2866	38	3H-MEPYRAMINE	-9	30	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		DB00540	2866	38	3H-MEPYRAMINE	-9	30	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		2865	4143	73	3H-PYRILAMINE	-58	53	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	4143	73	3H-PYRILAMINE	-58	53	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	4143	73	3H-PYRILAMINE	-58	53	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	4143	73	3H-PYRILAMINE	-58	53	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	4143	73	3H-PYRILAMINE	-58	53	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		21722	17992	31	3H-MEPYRAMINE	-5	6	Guinea pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	None
		CHEMBL126224	17992	31	3H-MEPYRAMINE	-5	6	Guinea pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	None
		1204	1932	119	3H-MEPYRAMINE	-46	24	Guinea pig	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	3H-MEPYRAMINE	-46	24	Guinea pig	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	3H-MEPYRAMINE	-46	24	Guinea pig	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	3H-MEPYRAMINE	-46	24	Guinea pig	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	3H-MEPYRAMINE	-46	24	Guinea pig	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	3H-MEPYRAMINE	-46	24	Guinea pig	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1204	1932	119	3H-MEPYRAMINE	-46	24	Guinea pig	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	3H-MEPYRAMINE	-46	24	Guinea pig	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	3H-MEPYRAMINE	-46	24	Guinea pig	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	3H-MEPYRAMINE	-46	24	Guinea pig	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	3H-MEPYRAMINE	-46	24	Guinea pig	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	3H-MEPYRAMINE	-46	24	Guinea pig	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		2865	4143	73	UNDEFINED	-58	53	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	4143	73	UNDEFINED	-58	53	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	4143	73	UNDEFINED	-58	53	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	4143	73	UNDEFINED	-58	53	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	4143	73	UNDEFINED	-58	53	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		2470	3653	50	UNDEFINED	-4570	59	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	UNDEFINED	-4570	59	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	UNDEFINED	-4570	59	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	UNDEFINED	-4570	59	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	UNDEFINED	-4570	59	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		2470	3653	50	3H-doxepin	-4570	59	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	3H-doxepin	-4570	59	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	3H-doxepin	-4570	59	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	3H-doxepin	-4570	59	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	3H-doxepin	-4570	59	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		1613	2348	53	UNDEFINED	-3	44	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	2348	53	UNDEFINED	-3	44	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	2348	53	UNDEFINED	-3	44	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	2348	53	UNDEFINED	-3	44	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	2348	53	UNDEFINED	-3	44	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		1816	2540	102	3H-PYRILAMINE	-10	18	Guinea pig	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		4205	2540	102	3H-PYRILAMINE	-10	18	Guinea pig	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		7241	2540	102	3H-PYRILAMINE	-10	18	Guinea pig	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		CHEMBL654	2540	102	3H-PYRILAMINE	-10	18	Guinea pig	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		DB00370	2540	102	3H-PYRILAMINE	-10	18	Guinea pig	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		2389	3331	118	3H-PYRILAMINE	-46	67	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-PYRILAMINE	-46	67	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-PYRILAMINE	-46	67	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-PYRILAMINE	-46	67	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-PYRILAMINE	-46	67	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		1548955	88581	20	None	1	18	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	None
		2800	88581	20	None	1	18	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	None
		CHEMBL2355051	88581	20	None	1	18	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	None
		2389	3331	118	3H-PYRILAMINE	-46	67	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-PYRILAMINE	-46	67	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-PYRILAMINE	-46	67	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-PYRILAMINE	-46	67	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-PYRILAMINE	-46	67	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		2865	4143	73	3H-PYRILAMINE	-17	53	Guinea pig	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	4143	73	3H-PYRILAMINE	-17	53	Guinea pig	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	4143	73	3H-PYRILAMINE	-17	53	Guinea pig	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	4143	73	3H-PYRILAMINE	-17	53	Guinea pig	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	4143	73	3H-PYRILAMINE	-17	53	Guinea pig	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		2142	3096	58	None	-263	36	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4920903	3096	58	None	-263	36	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		502	3096	58	None	-263	36	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		5775	3096	58	None	-263	36	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		CHEMBL597	3096	58	None	-263	36	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		DB00692	3096	58	None	-263	36	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		2812	4779	101	None	-28	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	None
		CHEMBL104	4779	101	None	-28	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	None
		40589	216144	0	None	-5	8	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	377	7	0	6	2.5	CCC1=NN(C(=O)N1CC)CCCN2CCN(CC2)C3=CC(=CC=C3)Cl	None
		4528	98126	80	None	-1	10	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	238	1	1	2	2.8	CN1Cc2c(N)cccc2C(c2ccccc2)C1	None
		CHEMBL273575	98126	80	None	-1	10	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	238	1	1	2	2.8	CN1Cc2c(N)cccc2C(c2ccccc2)C1	None
		3114	189927	71	None	-	1	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	339	8	1	3	3.4	CC(C)N(CCC(C(N)=O)(c1ccccc1)c1ccccn1)C(C)C	None
		CHEMBL517	189927	71	None	-	1	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	339	8	1	3	3.4	CC(C)N(CCC(C(N)=O)(c1ccccc1)c1ccccn1)C(C)C	None
		2181	3128	46	None	-269	35	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		4830	3128	46	None	-269	35	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		92	3128	46	None	-269	35	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		CHEMBL440294	3128	46	None	-269	35	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		DB09286	3128	46	None	-269	35	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		135398745	2914	112	UNDEFINED	-1	65	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	UNDEFINED	-1	65	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	UNDEFINED	-1	65	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	UNDEFINED	-1	65	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		1228	3866	34	3H-MEPYRAMINE	-6	4	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		2763	3866	34	3H-MEPYRAMINE	-6	4	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		5282443	3866	34	3H-MEPYRAMINE	-6	4	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		CHEMBL855	3866	34	3H-MEPYRAMINE	-6	4	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		DB00427	3866	34	3H-MEPYRAMINE	-6	4	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		657255	199084	34	None	-18	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	None
		CHEMBL588119	199084	34	None	-18	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	None
		115237	55585	119	3H-PYRILAMINE	-36	54	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		CHEMBL1621	55585	119	3H-PYRILAMINE	-36	54	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		446220	133521	14	None	-19	45	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	303	3	0	5	1.9	COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C	None
		CHEMBL370805	133521	14	None	-19	45	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	303	3	0	5	1.9	COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C	None
		1830	2590	44	None	-125	28	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		207	2590	44	None	-125	28	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		23897	2590	44	None	-125	28	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		CHEMBL460	2590	44	None	-125	28	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		DB01618	2590	44	None	-125	28	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		5281878	1660	35	3H-MEPYRAMINE	-1	17	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281881	1660	35	3H-MEPYRAMINE	-1	17	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		948	1660	35	3H-MEPYRAMINE	-1	17	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		968	1660	35	3H-MEPYRAMINE	-1	17	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL42055	1660	35	3H-MEPYRAMINE	-1	17	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL54661	1660	35	3H-MEPYRAMINE	-1	17	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00875	1660	35	3H-MEPYRAMINE	-1	17	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		103	4153	61	3H-PYRILAMINE	-1	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	4153	61	3H-PYRILAMINE	-1	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	4153	61	3H-PYRILAMINE	-1	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	4153	61	3H-PYRILAMINE	-1	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	4153	61	3H-PYRILAMINE	-1	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		4066	204626	78	3H-doxepin	-1	7	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	None
		CHEMBL73451	204626	78	3H-doxepin	-1	7	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	None
		1621	2429	17	None	-301	45	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards Histamine H1 receptorBinding affinity towards Histamine H1 receptor	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		17	2429	17	None	-301	45	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards Histamine H1 receptorBinding affinity towards Histamine H1 receptor	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		5761	2429	17	None	-301	45	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards Histamine H1 receptorBinding affinity towards Histamine H1 receptor	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL263881	2429	17	None	-301	45	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards Histamine H1 receptorBinding affinity towards Histamine H1 receptor	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB04829	2429	17	None	-301	45	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards Histamine H1 receptorBinding affinity towards Histamine H1 receptor	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		11954259	215979	0	UNDEFINED	-19	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
		107782	14468	18	None	1	5	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	472	4	4	6	2.0	C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)(O)O	None
		67151996	14468	18	None	1	5	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	472	4	4	6	2.0	C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)(O)O	None
		CHEMBL1201207	14468	18	None	1	5	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	472	4	4	6	2.0	C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)(O)O	None
		5048	3133	64	None	-109	7	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysis	Drug Central	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	None
		8924	3133	64	None	-109	7	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysis	Drug Central	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	None
		9948102	3133	64	None	-109	7	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysis	Drug Central	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	None
		CHEMBL462605	3133	64	None	-109	7	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysis	Drug Central	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	None
		DB11642	3133	64	None	-109	7	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysis	Drug Central	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	None
		1209	1658	75	None	-144	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		203	1658	75	None	-144	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		3386	1658	75	None	-144	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		CHEMBL41	1658	75	None	-144	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		DB00472	1658	75	None	-144	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		2181	3128	46	3H-PYRILAMINE	-4168	35	Guinea pig	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		4830	3128	46	3H-PYRILAMINE	-4168	35	Guinea pig	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		92	3128	46	3H-PYRILAMINE	-4168	35	Guinea pig	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		CHEMBL440294	3128	46	3H-PYRILAMINE	-4168	35	Guinea pig	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		DB09286	3128	46	3H-PYRILAMINE	-4168	35	Guinea pig	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		46882182	5921	0	UNDEFINED	-95	5	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	567	11	1	9	4.7	CCOc1cc(CN2CCC(Nc3nc4cc(S(=O)(=O)N(C)C)ccc4o3)CC2)cc(OCC)c1-n1cccc1	None
		CHEMBL1079686	5921	0	UNDEFINED	-95	5	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	567	11	1	9	4.7	CCOc1cc(CN2CCC(Nc3nc4cc(S(=O)(=O)N(C)C)ccc4o3)CC2)cc(OCC)c1-n1cccc1	None
		53389	98447	23	3H-MEPYRAMINE	1	6	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	3.9	C[C@H]1CN(CCCn2c3ccccc3c3ccccc32)C[C@@H](C)N1	None
		CHEMBL275707	98447	23	3H-MEPYRAMINE	1	6	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	3.9	C[C@H]1CN(CCCn2c3ccccc3c3ccccc32)C[C@@H](C)N1	None
		68617	205527	62	3H-PYRILAMINE	-1023	26	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		CHEMBL1709	205527	62	3H-PYRILAMINE	-1023	26	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		CHEMBL809	205527	62	3H-PYRILAMINE	-1023	26	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		None	216135	0	3H-KETANSERIN	-5248	24	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	772	16	4	10	5.5	CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.C(=CC(=O)O)C(=O)O	None
		191	403	98	3H-Histamine	-56	29	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		201	403	98	3H-Histamine	-56	29	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		2170	403	98	3H-Histamine	-56	29	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		CHEMBL1113	403	98	3H-Histamine	-56	29	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		DB00543	403	98	3H-Histamine	-56	29	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		1353	1911	93	3H-MEPYRAMINE	-602	83	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-MEPYRAMINE	-602	83	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-MEPYRAMINE	-602	83	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-MEPYRAMINE	-602	83	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-MEPYRAMINE	-602	83	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		68617	205527	62	3H-PYRILAMINE	-831	26	Guinea pig	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		CHEMBL1709	205527	62	3H-PYRILAMINE	-831	26	Guinea pig	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		CHEMBL809	205527	62	3H-PYRILAMINE	-831	26	Guinea pig	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		2865	4143	73	UNDEFINED	-1047	53	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	4143	73	UNDEFINED	-1047	53	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	4143	73	UNDEFINED	-1047	53	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	4143	73	UNDEFINED	-1047	53	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	4143	73	UNDEFINED	-1047	53	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		5568	197500	29	3H-MEPYRAMINE	-25	5	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	None
		66069	197500	29	3H-MEPYRAMINE	-25	5	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	None
		CHEMBL1201102	197500	29	3H-MEPYRAMINE	-25	5	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	None
		CHEMBL570	197500	29	3H-MEPYRAMINE	-25	5	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	None
		11848677	148352	0	UNDEFINED	-1	5	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	460	8	2	8	3.0	CCOc1cc(CN2CCC(Nc3nc4cc(S(N)(=O)=O)ccc4o3)CC2)ccc1OC	None
		CHEMBL393718	148352	0	UNDEFINED	-1	5	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	460	8	2	8	3.0	CCOc1cc(CN2CCC(Nc3nc4cc(S(N)(=O)=O)ccc4o3)CC2)ccc1OC	None
		1222	1664	49	3H-PYRILAMINE	-891	33	Guinea pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3396	1664	49	3H-PYRILAMINE	-891	33	Guinea pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		85	1664	49	3H-PYRILAMINE	-891	33	Guinea pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL46516	1664	49	3H-PYRILAMINE	-891	33	Guinea pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		DB04842	1664	49	3H-PYRILAMINE	-891	33	Guinea pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		1209	1658	75	3H-PYRILAMINE	-144	32	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		203	1658	75	3H-PYRILAMINE	-144	32	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		3386	1658	75	3H-PYRILAMINE	-144	32	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		CHEMBL41	1658	75	3H-PYRILAMINE	-144	32	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		DB00472	1658	75	3H-PYRILAMINE	-144	32	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		54841	203127	52	3H-PYRILAMINE	-2	27	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	None
		CHEMBL641	203127	52	3H-PYRILAMINE	-2	27	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	None
		44591012	175580	0	UNDEFINED	-114	6	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	522	10	0	3	6.6	CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)Cc1ccc(OCCCN2CCCCC2)cc1	None
		CHEMBL457957	175580	0	UNDEFINED	-114	6	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	522	10	0	3	6.6	CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)Cc1ccc(OCCCN2CCCCC2)cc1	None
		1192	147	47	3H-MEPYRAMINE	-91	17	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	None
		1794	147	47	3H-MEPYRAMINE	-91	17	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	None
		CHEMBL501701	147	47	3H-MEPYRAMINE	-91	17	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	None
		2435	3590	83	3H-PYRILAMINE	-1122	48	Guinea pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		60149	3590	83	3H-PYRILAMINE	-1122	48	Guinea pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		98	3590	83	3H-PYRILAMINE	-1122	48	Guinea pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		CHEMBL12713	3590	83	3H-PYRILAMINE	-1122	48	Guinea pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		DB06144	3590	83	3H-PYRILAMINE	-1122	48	Guinea pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		15387	45822	55	3H-PYRILAMINE	-8	24	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
		CHEMBL1531134	45822	55	3H-PYRILAMINE	-8	24	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
		12057539	208041	42	3H-MEPYRAMINE	-676	20	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	208041	42	3H-MEPYRAMINE	-676	20	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	208041	42	3H-MEPYRAMINE	-676	20	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		33630	178957	99	None	-13	28	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]Pyrilamine from human H1 receptor expressed in HEK cells by radioligand binding assay	Drug Central	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
		CHEMBL47050	178957	99	None	-13	28	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]Pyrilamine from human H1 receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]Pyrilamine from human H1 receptor expressed in HEK cells by radioligand binding assay	Drug Central	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
		2726	919	68	3H-PYRILAMINE	-2	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	3H-PYRILAMINE	-2	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	3H-PYRILAMINE	-2	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	3H-PYRILAMINE	-2	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	3H-PYRILAMINE	-2	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		135398737	958	93	3H-PYRILAMINE	-4	89	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-PYRILAMINE	-4	89	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-PYRILAMINE	-4	89	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-PYRILAMINE	-4	89	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-PYRILAMINE	-4	89	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		11954259	215979	0	3H-doxepin	-19	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
		None	216149	0	3H-MEPYRAMINE	-	1	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	411	6	0	1	0.8	CC1=CC=C(C=C1)C(C2=CC=CC=C2)OCC[N+](C)(C)C.[I-]	None
		6834	205552	45	3H-PYRILAMINE	-1	2	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	318	5	0	2	3.9	CN(C)CCC(c1ccc(Br)cc1)c1ccccn1	None
		CHEMBL811	205552	45	3H-PYRILAMINE	-1	2	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	318	5	0	2	3.9	CN(C)CCC(c1ccc(Br)cc1)c1ccccn1	None
		1224	1432	83	3H-MEPYRAMINE	-2	13	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		3100	1432	83	3H-MEPYRAMINE	-2	13	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		8980	1432	83	3H-MEPYRAMINE	-2	13	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		916	1432	83	3H-MEPYRAMINE	-2	13	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		CHEMBL657	1432	83	3H-MEPYRAMINE	-2	13	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		DB01075	1432	83	3H-MEPYRAMINE	-2	13	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		2448	99323	70	None	-4	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
		CHEMBL28218	99323	70	None	-4	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
		15723	18539	111	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation counting	Drug Central	267	3	2	2	2.9	OC(c1ccccc1)(c1ccccc1)C1CCNCC1	None
		CHEMBL127508	18539	111	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation countingDisplacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation counting	Drug Central	267	3	2	2	2.9	OC(c1ccccc1)(c1ccccc1)C1CCNCC1	None
		213	3853	55	None	-8	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		2717	3853	55	None	-8	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		5533	3853	55	None	-8	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		CHEMBL621	3853	55	None	-8	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		DB00656	3853	55	None	-8	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		4020	205150	39	None	-	1	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	284	1	1	3	2.6	OC1(c2ccc(Cl)cc2)c2ccccc2C2=NCCN21	None
		CHEMBL781	205150	39	None	-	1	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	284	1	1	3	2.6	OC1(c2ccc(Cl)cc2)c2ccccc2C2=NCCN21	None
		15387	45822	55	None	-8	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
		CHEMBL1531134	45822	55	None	-8	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
		3168	9262	92	None	-87	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	None
		CHEMBL1108	9262	92	None	-87	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	None
		1222	881	0	3H-MEPYRAMINE	-1	2	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		2678	881	0	3H-MEPYRAMINE	-1	2	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		581	881	0	3H-MEPYRAMINE	-1	2	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		CHEMBL1000	881	0	3H-MEPYRAMINE	-1	2	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		DB00341	881	0	3H-MEPYRAMINE	-1	2	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		1971	2866	38	3H-PYRILAMINE	-1	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		2404	2866	38	3H-PYRILAMINE	-1	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		4543	2866	38	3H-PYRILAMINE	-1	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		CHEMBL445	2866	38	3H-PYRILAMINE	-1	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		DB00540	2866	38	3H-PYRILAMINE	-1	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		1222	881	0	3H-MEPYRAMINE	-1	2	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		2678	881	0	3H-MEPYRAMINE	-1	2	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		581	881	0	3H-MEPYRAMINE	-1	2	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		CHEMBL1000	881	0	3H-MEPYRAMINE	-1	2	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		DB00341	881	0	3H-MEPYRAMINE	-1	2	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		133	2496	52	None	-102	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	2496	52	None	-102	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	2496	52	None	-102	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	2496	52	None	-102	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	2496	52	None	-102	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		2470	3653	50	None	-4570	59	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	None	-4570	59	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	None	-4570	59	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	None	-4570	59	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	None	-4570	59	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		1353	1911	93	None	-489	83	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	None	-489	83	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	None	-489	83	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	None	-489	83	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	None	-489	83	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human cloned histamine H1 receptorBinding affinity to human cloned histamine H1 receptor	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1353	1911	93	None	-213	83	Guinea pig	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	None	-213	83	Guinea pig	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	None	-213	83	Guinea pig	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	None	-213	83	Guinea pig	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	None	-213	83	Guinea pig	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		2710	84308	31	3H-MEPYRAMINE	1	3	Guinea pig	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	300	3	0	2	3.7	CN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	None
		CHEMBL22150	84308	31	3H-MEPYRAMINE	1	3	Guinea pig	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	300	3	0	2	3.7	CN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	None
		1353	1911	93	None	-602	83	Rat	8.2	pKi	=	8.2	Binding	Half-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenateHalf-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenate	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	None	-602	83	Rat	8.2	pKi	=	8.2	Binding	Half-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenateHalf-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenate	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	None	-602	83	Rat	8.2	pKi	=	8.2	Binding	Half-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenateHalf-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenate	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	None	-602	83	Rat	8.2	pKi	=	8.2	Binding	Half-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenateHalf-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenate	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	None	-602	83	Rat	8.2	pKi	=	8.2	Binding	Half-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenateHalf-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenate	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1890	2759	49	None	-44	16	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
		4449	2759	49	None	-44	16	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
		7247	2759	49	None	-44	16	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
		CHEMBL623	2759	49	None	-44	16	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
		DB01149	2759	49	None	-44	16	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
		3947	206395	53	None	-7	16	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	None
		CHEMBL87708	206395	53	None	-7	16	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	None
		1605	2342	117	None	-2	4	Rat	8.2	pKi	=	8.2	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	Drug Central	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	None
		3957	2342	117	None	-2	4	Rat	8.2	pKi	=	8.2	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	Drug Central	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	None
		7216	2342	117	None	-2	4	Rat	8.2	pKi	=	8.2	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	Drug Central	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	None
		CHEMBL998	2342	117	None	-2	4	Rat	8.2	pKi	=	8.2	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	Drug Central	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	None
		DB00455	2342	117	None	-2	4	Rat	8.2	pKi	=	8.2	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	Drug Central	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	None
		2771	195017	74	None	-2	27	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL1200781	195017	74	None	-2	27	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL549	195017	74	None	-2	27	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		2712	916	34	None	-5	4	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	299	1	1	3	3.0	CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl	None
		3370	916	34	None	-5	4	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	299	1	1	3	3.0	CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl	None
		594	916	34	None	-5	4	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	299	1	1	3	3.0	CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl	None
		CHEMBL451	916	34	None	-5	4	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	299	1	1	3	3.0	CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl	None
		DB00475	916	34	None	-5	4	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	299	1	1	3	3.0	CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl	None
		2710	84308	31	3H-MEPYRAMINE	-1	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	300	3	0	2	3.7	CN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	None
		CHEMBL22150	84308	31	3H-MEPYRAMINE	-1	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	300	3	0	2	3.7	CN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	None
		2564	206184	51	3H-MEPYRAMINE	-2	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	290	6	0	3	3.4	CN(C)CCOC(c1ccc(Cl)cc1)c1ccccn1	None
		CHEMBL864	206184	51	3H-MEPYRAMINE	-2	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	290	6	0	3	3.4	CN(C)CCOC(c1ccc(Cl)cc1)c1ccccn1	None
		16362	3125	71	None	-489	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		2172	3125	71	None	-489	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		90	3125	71	None	-489	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		CHEMBL1423	3125	71	None	-489	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		DB01100	3125	71	None	-489	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		4806	4008	88	None	-5	13	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
		7351	4008	88	None	-5	13	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
		9966051	4008	88	None	-5	13	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
		CHEMBL2104993	4008	88	None	-5	13	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
		DB09068	4008	88	None	-5	13	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human histamine H1 receptorBinding affinity to human histamine H1 receptor	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
		3151	1462	97	None	-41	27	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		945	1462	97	None	-41	27	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		965	1462	97	None	-41	27	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		CHEMBL219916	1462	97	None	-41	27	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		DB01184	1462	97	None	-41	27	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		21722	17992	31	None	1	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	None
		CHEMBL126224	17992	31	None	1	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	None
		1605	2342	117	None	-2	4	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	None
		3957	2342	117	None	-2	4	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	None
		7216	2342	117	None	-2	4	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	None
		CHEMBL998	2342	117	None	-2	4	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	None
		DB00455	2342	117	None	-2	4	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	None
		4976	203579	29	3H-MEPYRAMINE	-9	12	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	None
		CHEMBL668	203579	29	3H-MEPYRAMINE	-9	12	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	None
		2995	204405	53	3H-PYRILAMINE	-14	23	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL1696	204405	53	3H-PYRILAMINE	-14	23	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL72	204405	53	3H-PYRILAMINE	-14	23	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		4020	205150	39	3H-MEPYRAMINE	-	1	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	284	1	1	3	2.6	OC1(c2ccc(Cl)cc2)c2ccccc2C2=NCCN21	None
		CHEMBL781	205150	39	3H-MEPYRAMINE	-	1	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	284	1	1	3	2.6	OC1(c2ccc(Cl)cc2)c2ccccc2C2=NCCN21	None
		2303	3187	68	3H-MEPYRAMINE	-363	26	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		4946	3187	68	3H-MEPYRAMINE	-363	26	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		564	3187	68	3H-MEPYRAMINE	-363	26	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		63	3187	68	3H-MEPYRAMINE	-363	26	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		91536	3187	68	3H-MEPYRAMINE	-363	26	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		CHEMBL27	3187	68	3H-MEPYRAMINE	-363	26	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		CHEMBL452861	3187	68	3H-MEPYRAMINE	-363	26	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		DB00571	3187	68	3H-MEPYRAMINE	-363	26	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		45485462	197686	0	UNDEFINED	-	1	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	419	8	1	2	6.6	CC1CCC(CCCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)CC1	None
		CHEMBL571174	197686	0	UNDEFINED	-	1	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	419	8	1	2	6.6	CC1CCC(CCCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)CC1	None
		2200	20203	61	3H-MEPYRAMINE	-26	2	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	None
		CHEMBL1256819	20203	61	3H-MEPYRAMINE	-26	2	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	None
		CHEMBL1305	20203	61	3H-MEPYRAMINE	-26	2	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	None
		1224	1432	83	3H-doxepin	-2	13	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		3100	1432	83	3H-doxepin	-2	13	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		8980	1432	83	3H-doxepin	-2	13	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		916	1432	83	3H-doxepin	-2	13	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		CHEMBL657	1432	83	3H-doxepin	-2	13	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		DB01075	1432	83	3H-doxepin	-2	13	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		214	3860	58	3H-doxepin	-43	30	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2740	3860	58	3H-doxepin	-43	30	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5566	3860	58	3H-doxepin	-43	30	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		66064	3860	58	3H-doxepin	-43	30	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL422	3860	58	3H-doxepin	-43	30	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00831	3860	58	3H-doxepin	-43	30	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		214	3860	58	UNDEFINED	-43	30	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2740	3860	58	UNDEFINED	-43	30	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5566	3860	58	UNDEFINED	-43	30	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		66064	3860	58	UNDEFINED	-43	30	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL422	3860	58	UNDEFINED	-43	30	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00831	3860	58	UNDEFINED	-43	30	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		11848624	89146	0	UNDEFINED	-15	6	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	381	7	1	6	4.3	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1OC	None
		CHEMBL236587	89146	0	UNDEFINED	-15	6	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	381	7	1	6	4.3	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1OC	None
		214	3860	58	3H-PYRILAMINE	-43	30	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2740	3860	58	3H-PYRILAMINE	-43	30	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5566	3860	58	3H-PYRILAMINE	-43	30	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		66064	3860	58	3H-PYRILAMINE	-43	30	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL422	3860	58	3H-PYRILAMINE	-43	30	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00831	3860	58	3H-PYRILAMINE	-43	30	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		1204	1932	119	3H-MEPYRAMINE	-501	24	Human	4.2	pKi	=	4.2	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	3H-MEPYRAMINE	-501	24	Human	4.2	pKi	=	4.2	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	3H-MEPYRAMINE	-501	24	Human	4.2	pKi	=	4.2	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	3H-MEPYRAMINE	-501	24	Human	4.2	pKi	=	4.2	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	3H-MEPYRAMINE	-501	24	Human	4.2	pKi	=	4.2	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	3H-MEPYRAMINE	-501	24	Human	4.2	pKi	=	4.2	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		13091273	182438	0	UNDEFINED	-275	6	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	367	6	1	3	4.3	O=C(CCCN1C2CCC1CC(O)(c1ccccc1)C2)c1ccc(F)cc1	None
		CHEMBL478617	182438	0	UNDEFINED	-275	6	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	367	6	1	3	4.3	O=C(CCCN1C2CCC1CC(O)(c1ccccc1)C2)c1ccc(F)cc1	None
		CHEMBL553327	182438	0	UNDEFINED	-275	6	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	367	6	1	3	4.3	O=C(CCCN1C2CCC1CC(O)(c1ccccc1)C2)c1ccc(F)cc1	None
		45485529	197718	0	UNDEFINED	-	1	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	385	6	1	2	5.2	Cc1ccc(CCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1	None
		CHEMBL571391	197718	0	UNDEFINED	-	1	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	385	6	1	2	5.2	Cc1ccc(CCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1	None
		54841	203127	52	3H-Histamine	-6	27	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	None
		CHEMBL641	203127	52	3H-Histamine	-6	27	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	None
		68617	205527	62	3H-PYRILAMINE	-831	26	Guinea pig	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		CHEMBL1709	205527	62	3H-PYRILAMINE	-831	26	Guinea pig	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		CHEMBL809	205527	62	3H-PYRILAMINE	-831	26	Guinea pig	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		15723	18539	111	UNDEFINED	-	1	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	267	3	2	2	2.9	OC(c1ccccc1)(c1ccccc1)C1CCNCC1	None
		CHEMBL127508	18539	111	UNDEFINED	-	1	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	267	3	2	2	2.9	OC(c1ccccc1)(c1ccccc1)C1CCNCC1	None
		185	4006	60	3H-PYRILAMINE	-794	37	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		5311271	4006	60	3H-PYRILAMINE	-794	37	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		CHEMBL74355	4006	60	3H-PYRILAMINE	-794	37	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		DB16351	4006	60	3H-PYRILAMINE	-794	37	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		2470	3653	50	3H-MEPYRAMINE	-4570	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	3H-MEPYRAMINE	-4570	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	3H-MEPYRAMINE	-4570	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	3H-MEPYRAMINE	-4570	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	3H-MEPYRAMINE	-4570	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		1212	1662	50	3H-PYRILAMINE	-41	65	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		1212	1662	50	3H-MEPYRAMINE	-134	65	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	1662	50	3H-PYRILAMINE	-41	65	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	1662	50	3H-MEPYRAMINE	-134	65	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	1662	50	3H-PYRILAMINE	-41	65	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	1662	50	3H-MEPYRAMINE	-134	65	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	1662	50	3H-PYRILAMINE	-41	65	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	1662	50	3H-MEPYRAMINE	-134	65	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	1662	50	3H-PYRILAMINE	-41	65	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	1662	50	3H-MEPYRAMINE	-134	65	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2470	3653	50	3H-MEPYRAMINE	-20417	59	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	3H-MEPYRAMINE	-20417	59	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	3H-MEPYRAMINE	-20417	59	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	3H-MEPYRAMINE	-20417	59	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	3H-MEPYRAMINE	-20417	59	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		21722	17992	31	3H-MEPYRAMINE	1	6	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	None
		CHEMBL126224	17992	31	3H-MEPYRAMINE	1	6	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	None
		44591098	176762	0	UNDEFINED	-199	6	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	508	9	0	3	6.6	CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)c1ccc(OCCCN2CCCCC2)cc1	None
		CHEMBL460402	176762	0	UNDEFINED	-199	6	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	508	9	0	3	6.6	CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)c1ccc(OCCCN2CCCCC2)cc1	None
		16362	3125	71	3H-PYRILAMINE	-489	30	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		2172	3125	71	3H-PYRILAMINE	-489	30	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		90	3125	71	3H-PYRILAMINE	-489	30	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		CHEMBL1423	3125	71	3H-PYRILAMINE	-489	30	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		DB01100	3125	71	3H-PYRILAMINE	-489	30	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		242	470	124	None	-23	51	Guinea pig	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	470	124	None	-23	51	Guinea pig	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	470	124	None	-23	51	Guinea pig	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	470	124	None	-23	51	Guinea pig	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	470	124	None	-23	51	Guinea pig	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		1613	2348	53	3H-PYRILAMINE	-3	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	2348	53	3H-PYRILAMINE	-3	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	2348	53	3H-PYRILAMINE	-3	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	2348	53	3H-PYRILAMINE	-3	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	2348	53	3H-PYRILAMINE	-3	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		135398745	2914	112	UNDEFINED	1	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		135398745	2914	112	3H-PYRILAMINE	-1	65	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	UNDEFINED	1	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-PYRILAMINE	-1	65	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	UNDEFINED	1	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-PYRILAMINE	-1	65	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	UNDEFINED	1	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-PYRILAMINE	-1	65	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		22530	56130	58	None	-1	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	None
		CHEMBL1600878	56130	58	None	-1	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	None
		CHEMBL1625607	56130	58	None	-1	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	None
		2995	204405	53	None	-14	23	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL1696	204405	53	None	-14	23	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL72	204405	53	None	-14	23	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		11579	635	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	inhibition of [3H]-pyrilamine binding to human recombinant histamine H1-receptorsinhibition of [3H]-pyrilamine binding to human recombinant histamine H1-receptors	Drug Central	463	10	1	5	4.9	CCOCCn1c(nc2c1cccc2)C1CCN(CC1)CCc1ccc(cc1)C(C(=O)O)(C)C	None
		185460	635	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	inhibition of [3H]-pyrilamine binding to human recombinant histamine H1-receptorsinhibition of [3H]-pyrilamine binding to human recombinant histamine H1-receptors	Drug Central	463	10	1	5	4.9	CCOCCn1c(nc2c1cccc2)C1CCN(CC1)CCc1ccc(cc1)C(C(=O)O)(C)C	None
		CHEMBL1742423	635	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	inhibition of [3H]-pyrilamine binding to human recombinant histamine H1-receptorsinhibition of [3H]-pyrilamine binding to human recombinant histamine H1-receptors	Drug Central	463	10	1	5	4.9	CCOCCn1c(nc2c1cccc2)C1CCN(CC1)CCc1ccc(cc1)C(C(=O)O)(C)C	None
		DB11591	635	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	inhibition of [3H]-pyrilamine binding to human recombinant histamine H1-receptorsinhibition of [3H]-pyrilamine binding to human recombinant histamine H1-receptors	Drug Central	463	10	1	5	4.9	CCOCCn1c(nc2c1cccc2)C1CCN(CC1)CCc1ccc(cc1)C(C(=O)O)(C)C	None
		214	3860	58	None	-43	30	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2740	3860	58	None	-43	30	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5566	3860	58	None	-43	30	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		66064	3860	58	None	-43	30	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL422	3860	58	None	-43	30	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00831	3860	58	None	-43	30	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		242	470	124	None	-22	51	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	470	124	None	-22	51	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	470	124	None	-22	51	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	470	124	None	-22	51	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	470	124	None	-22	51	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		49831411	217746	0	None	-1	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	659	19	0	6	8.7	CCCCCCCCCCCC(=O)OCN1C(=O)CCC2=CC=C(OCCCCN3CCN(CC3)C3=C(Cl)C(Cl)=CC=C3)C=C12	None
		4976	203579	29	None	-1	12	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	None
		CHEMBL668	203579	29	None	-1	12	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	None
		146159772	2311	33	None	2	3	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	420	4	1	3	4.9	N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F	None
		1564	2311	33	None	2	3	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	420	4	1	3	4.9	N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F	None
		1586	2311	33	None	2	3	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	420	4	1	3	4.9	N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F	None
		54385	2311	33	None	2	3	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	420	4	1	3	4.9	N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F	None
		CHEMBL1615438	2311	33	None	2	3	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	420	4	1	3	4.9	N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F	None
		DB01106	2311	33	None	2	3	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	420	4	1	3	4.9	N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F	None
		2726	919	68	None	-6	72	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	None	-6	72	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	None	-6	72	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	None	-6	72	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	None	-6	72	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		1212	1662	50	3H-PYRILAMINE	-41	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	1662	50	3H-PYRILAMINE	-41	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	1662	50	3H-PYRILAMINE	-41	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	1662	50	3H-PYRILAMINE	-41	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	1662	50	3H-PYRILAMINE	-41	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2865	4143	73	None	-58	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	4143	73	None	-58	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	4143	73	None	-58	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	4143	73	None	-58	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	4143	73	None	-58	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		2337	3256	77	None	-1	62	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	None	-1	62	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	None	-1	62	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	None	-1	62	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	None	-1	62	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		2389	3331	118	None	-46	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	None	-46	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	None	-46	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	None	-46	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	None	-46	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		2337	3256	77	3H-PYRILAMINE	1	62	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	3H-PYRILAMINE	1	62	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	3H-PYRILAMINE	1	62	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	3H-PYRILAMINE	1	62	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	3H-PYRILAMINE	1	62	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5440	28724	37	None	-1	9	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	None
		CHEMBL1378	28724	37	None	-1	9	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	None
		11154555	800	62	None	-56	12	Human	8.1	pKi	=	8.1	Binding	CHO-1 cells, [3H]Pyrilamine (1.5nM)CHO-1 cells, [3H]Pyrilamine (1.5nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		5037	800	62	None	-56	12	Human	8.1	pKi	=	8.1	Binding	CHO-1 cells, [3H]Pyrilamine (1.5nM)CHO-1 cells, [3H]Pyrilamine (1.5nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		7671	800	62	None	-56	12	Human	8.1	pKi	=	8.1	Binding	CHO-1 cells, [3H]Pyrilamine (1.5nM)CHO-1 cells, [3H]Pyrilamine (1.5nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL2028019	800	62	None	-56	12	Human	8.1	pKi	=	8.1	Binding	CHO-1 cells, [3H]Pyrilamine (1.5nM)CHO-1 cells, [3H]Pyrilamine (1.5nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL3085826	800	62	None	-56	12	Human	8.1	pKi	=	8.1	Binding	CHO-1 cells, [3H]Pyrilamine (1.5nM)CHO-1 cells, [3H]Pyrilamine (1.5nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB06016	800	62	None	-56	12	Human	8.1	pKi	=	8.1	Binding	CHO-1 cells, [3H]Pyrilamine (1.5nM)CHO-1 cells, [3H]Pyrilamine (1.5nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		2389	3331	118	None	-52	67	Guinea pig	8.1	pKi	=	8.1	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysisDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysis	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	None	-52	67	Guinea pig	8.1	pKi	=	8.1	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysisDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysis	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	None	-52	67	Guinea pig	8.1	pKi	=	8.1	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysisDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysis	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	None	-52	67	Guinea pig	8.1	pKi	=	8.1	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysisDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysis	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	None	-52	67	Guinea pig	8.1	pKi	=	8.1	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysisDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysis	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		3389	217711	0	None	-1	26	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	549	12	0	6	6.8	CCCCCCC(=O)OCCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1	None
		100	3805	58	None	-7	55	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	3805	58	None	-7	55	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	3805	58	None	-7	55	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	3805	58	None	-7	55	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	3805	58	None	-7	55	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		1385580	29276	76	None	-1	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	None
		4615	29276	76	None	-1	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	None
		CHEMBL13828	29276	76	None	-1	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	None
		1588	2325	27	None	-35	44	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		28864	2325	27	None	-35	44	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		43	2325	27	None	-35	44	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL157138	2325	27	None	-35	44	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB00589	2325	27	None	-35	44	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		11978813	721	79	None	-9	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
		5014	721	79	None	-9	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
		7672	721	79	None	-9	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
		CHEMBL2105760	721	79	None	-9	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
		DB09128	721	79	None	-9	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
		2274	3173	58	None	-3	31	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		4917	3173	58	None	-3	31	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		7279	3173	58	None	-3	31	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		CHEMBL728	3173	58	None	-3	31	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		DB00433	3173	58	None	-3	31	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		12488	1657	56	None	-2	23	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	None
		941361	1657	56	None	-2	23	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	None
		CHEMBL30008	1657	56	None	-2	23	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	None
		DB04841	1657	56	None	-2	23	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	None
		1212	1662	50	None	-41	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	1662	50	None	-41	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	1662	50	None	-41	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	1662	50	None	-41	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	1662	50	None	-41	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		25271818	12967	58	None	-1	2	Guinea pig	8.1	pKi	=	8.1	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	Drug Central	337	5	1	3	3.6	CN(C)CC/C=C1/c2ccccc2COc2ccc(CC(=O)O)cc21	None
		5281071	12967	58	None	-1	2	Guinea pig	8.1	pKi	=	8.1	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	Drug Central	337	5	1	3	3.6	CN(C)CC/C=C1/c2ccccc2COc2ccc(CC(=O)O)cc21	None
		CHEMBL1189432	12967	58	None	-1	2	Guinea pig	8.1	pKi	=	8.1	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	Drug Central	337	5	1	3	3.6	CN(C)CC/C=C1/c2ccccc2COc2ccc(CC(=O)O)cc21	None
		CHEMBL1719	12967	58	None	-1	2	Guinea pig	8.1	pKi	=	8.1	Binding	Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMBinding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	Drug Central	337	5	1	3	3.6	CN(C)CC/C=C1/c2ccccc2COc2ccc(CC(=O)O)cc21	None
		2865	4143	73	None	-17	53	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	4143	73	None	-17	53	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	4143	73	None	-17	53	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	4143	73	None	-17	53	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	4143	73	None	-17	53	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		1224	1432	83	None	-2	13	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		3100	1432	83	None	-2	13	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		8980	1432	83	None	-2	13	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		916	1432	83	None	-2	13	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		CHEMBL657	1432	83	None	-2	13	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		DB01075	1432	83	None	-2	13	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		1222	1664	49	None	-17	33	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3396	1664	49	None	-17	33	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		85	1664	49	None	-17	33	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL46516	1664	49	None	-17	33	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		DB04842	1664	49	None	-17	33	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		1222	881	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		2678	881	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		581	881	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		CHEMBL1000	881	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		DB00341	881	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		3294	2006	111	None	-14	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		71360	2006	111	None	-14	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		87	2006	111	None	-14	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		CHEMBL14376	2006	111	None	-14	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		DB04946	2006	111	None	-14	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		1214	2068	54	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1	None
		1549000	2068	54	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1	None
		1566	2068	54	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1	None
		28145931	2068	54	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1	None
		CHEMBL1201191	2068	54	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1	None
		DB06282	2068	54	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1	None
		191	403	98	None	-56	29	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		201	403	98	None	-56	29	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		2170	403	98	None	-56	29	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		CHEMBL1113	403	98	None	-56	29	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		DB00543	403	98	None	-56	29	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		4601	206747	35	None	-1	16	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
		CHEMBL1201023	206747	35	None	-1	16	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
		CHEMBL900	206747	35	None	-1	16	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
		1212	1662	50	3H-MEPYRAMINE	-41	65	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	1662	50	3H-MEPYRAMINE	-41	65	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	1662	50	3H-MEPYRAMINE	-41	65	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	1662	50	3H-MEPYRAMINE	-41	65	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	1662	50	3H-MEPYRAMINE	-41	65	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		16667681	216153	0	3H-MEPYRAMINE	-33	3	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	390	7	1	5	3.5	CN(C)CCCC1=CC=CC=N1.C1=CC(=CC=C1OC(=O)C=CC(=O)O)Cl	None
		1204	1932	119	3H-MEPYRAMINE	-501	24	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	3H-MEPYRAMINE	-501	24	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	3H-MEPYRAMINE	-501	24	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	3H-MEPYRAMINE	-501	24	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	3H-MEPYRAMINE	-501	24	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	3H-MEPYRAMINE	-501	24	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1353	1911	93	3H-PYRILAMINE	-213	83	Guinea pig	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1353	1911	93	UNDEFINED	-602	83	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-PYRILAMINE	-213	83	Guinea pig	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	UNDEFINED	-602	83	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-PYRILAMINE	-213	83	Guinea pig	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	UNDEFINED	-602	83	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-PYRILAMINE	-213	83	Guinea pig	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	UNDEFINED	-602	83	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-PYRILAMINE	-213	83	Guinea pig	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	UNDEFINED	-602	83	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		73333	5963	31	UNDEFINED	-46	9	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	401	7	1	2	4.2	CCNC(=O)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
		CHEMBL1079935	5963	31	UNDEFINED	-46	9	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	401	7	1	2	4.2	CCNC(=O)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
		2771	195017	74	3H-PYRILAMINE	-6	27	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL1200781	195017	74	3H-PYRILAMINE	-6	27	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL549	195017	74	3H-PYRILAMINE	-6	27	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL146246	38278	0	3H-PYRILAMINE	-2041	10	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	401	5	1	5	2.2	NS(=O)(=O)c1ccc(N2CCN(CCC3OCCc4ccccc43)CC2)cc1	None
		44591099	176190	0	UNDEFINED	-295	6	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	494	10	0	3	7.0	CN(CCC=C1c2ccccc2CCc2ccccc21)Cc1ccc(OCCCN2CCCCC2)cc1	None
		CHEMBL459350	176190	0	UNDEFINED	-295	6	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	494	10	0	3	7.0	CN(CCC=C1c2ccccc2CCc2ccccc21)Cc1ccc(OCCCN2CCCCC2)cc1	None
		1353	1911	93	3H-PYRILAMINE	-489	83	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-PYRILAMINE	-489	83	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-PYRILAMINE	-489	83	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-PYRILAMINE	-489	83	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-PYRILAMINE	-489	83	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1170	1633	75	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	None
		3348	1633	75	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	None
		4819	1633	75	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	None
		74685737	1633	75	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	None
		CHEMBL914	1633	75	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	None
		DB00950	1633	75	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	None
		3191	102858	97	None	2	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	None
		CHEMBL305660	102858	97	None	2	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	None
		4066	204626	78	None	-1	7	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	None
		CHEMBL73451	204626	78	None	-1	7	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	None
		209	3057	97	3H-PYRILAMINE	-11	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		209	3057	97	3H-doxepin	-11	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		2113	3057	97	3H-PYRILAMINE	-11	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		2113	3057	97	3H-doxepin	-11	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		4748	3057	97	3H-PYRILAMINE	-11	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		4748	3057	97	3H-doxepin	-11	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		CHEMBL567	3057	97	3H-PYRILAMINE	-11	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		CHEMBL567	3057	97	3H-doxepin	-11	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		DB00850	3057	97	3H-PYRILAMINE	-11	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		DB00850	3057	97	3H-doxepin	-11	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		90475904	216022	0	3H-MEPYRAMINE	-6	6	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(C)CCC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2	None
		None	216174	0	3H-MEPYRAMINE	1258	2	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	408	7	2	4	3.9	CC(C1=CC=CC=N1)C2=C(CC3=CC=CC=C32)CCN(C)C.C(=CC(=O)O)C(=O)O	None
		2398	954	62	None	-1	29	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		2801	954	62	None	-1	29	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		701	954	62	None	-1	29	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		CHEMBL415	954	62	None	-1	29	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		DB01242	954	62	None	-1	29	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		1547484	940	74	None	-1	20	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		654	940	74	None	-1	20	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		9072	940	74	None	-1	20	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		CHEMBL43064	940	74	None	-1	20	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		DB00568	940	74	None	-1	20	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		3103	41658	49	None	-1	4	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	281	4	0	2	3.9	CN1CCC(OC(c2ccccc2)c2ccccc2)CC1	None
		CHEMBL1492	41658	49	None	-1	4	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	281	4	0	2	3.9	CN1CCC(OC(c2ccccc2)c2ccccc2)CC1	None
		11140	2519	49	None	-9	3	Human	8.1	pKi	=	8.1	Binding	Radioligand Binding Assay: The pharmacological profile of metopimazine, metopimazine acid (MPZA), domperidone, and metoclopramide were assessed by radioligand binding and by a functional antagonist assay. For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in buffer. The assay was terminated by rapid filtration, and the bound radioactive signal was determined by liquid scintillation counting.Radioligand Binding Assay: The pharmacological profile of metopimazine, metopimazine acid (MPZA), domperidone, and metoclopramide were assessed by radioligand binding and by a functional antagonist assay. For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in buffer. The assay was terminated by rapid filtration, and the bound radioactive signal was determined by liquid scintillation counting.	Drug Central	445	6	1	6	3.3	NC(=O)C1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)C	None
		1784	2519	49	None	-9	3	Human	8.1	pKi	=	8.1	Binding	Radioligand Binding Assay: The pharmacological profile of metopimazine, metopimazine acid (MPZA), domperidone, and metoclopramide were assessed by radioligand binding and by a functional antagonist assay. For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in buffer. The assay was terminated by rapid filtration, and the bound radioactive signal was determined by liquid scintillation counting.Radioligand Binding Assay: The pharmacological profile of metopimazine, metopimazine acid (MPZA), domperidone, and metoclopramide were assessed by radioligand binding and by a functional antagonist assay. For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in buffer. The assay was terminated by rapid filtration, and the bound radioactive signal was determined by liquid scintillation counting.	Drug Central	445	6	1	6	3.3	NC(=O)C1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)C	None
		26388	2519	49	None	-9	3	Human	8.1	pKi	=	8.1	Binding	Radioligand Binding Assay: The pharmacological profile of metopimazine, metopimazine acid (MPZA), domperidone, and metoclopramide were assessed by radioligand binding and by a functional antagonist assay. For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in buffer. The assay was terminated by rapid filtration, and the bound radioactive signal was determined by liquid scintillation counting.Radioligand Binding Assay: The pharmacological profile of metopimazine, metopimazine acid (MPZA), domperidone, and metoclopramide were assessed by radioligand binding and by a functional antagonist assay. For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in buffer. The assay was terminated by rapid filtration, and the bound radioactive signal was determined by liquid scintillation counting.	Drug Central	445	6	1	6	3.3	NC(=O)C1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)C	None
		CHEMBL398615	2519	49	None	-9	3	Human	8.1	pKi	=	8.1	Binding	Radioligand Binding Assay: The pharmacological profile of metopimazine, metopimazine acid (MPZA), domperidone, and metoclopramide were assessed by radioligand binding and by a functional antagonist assay. For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in buffer. The assay was terminated by rapid filtration, and the bound radioactive signal was determined by liquid scintillation counting.Radioligand Binding Assay: The pharmacological profile of metopimazine, metopimazine acid (MPZA), domperidone, and metoclopramide were assessed by radioligand binding and by a functional antagonist assay. For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in buffer. The assay was terminated by rapid filtration, and the bound radioactive signal was determined by liquid scintillation counting.	Drug Central	445	6	1	6	3.3	NC(=O)C1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)C	None
		DB13591	2519	49	None	-9	3	Human	8.1	pKi	=	8.1	Binding	Radioligand Binding Assay: The pharmacological profile of metopimazine, metopimazine acid (MPZA), domperidone, and metoclopramide were assessed by radioligand binding and by a functional antagonist assay. For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in buffer. The assay was terminated by rapid filtration, and the bound radioactive signal was determined by liquid scintillation counting.Radioligand Binding Assay: The pharmacological profile of metopimazine, metopimazine acid (MPZA), domperidone, and metoclopramide were assessed by radioligand binding and by a functional antagonist assay. For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in buffer. The assay was terminated by rapid filtration, and the bound radioactive signal was determined by liquid scintillation counting.	Drug Central	445	6	1	6	3.3	NC(=O)C1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)C	None
		209	3057	97	None	-11	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		2113	3057	97	None	-11	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		4748	3057	97	None	-11	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		CHEMBL567	3057	97	None	-11	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		DB00850	3057	97	None	-11	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		1210	918	51	None	-20	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		1213	918	51	None	-20	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		2725	918	51	None	-20	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		33036	918	51	None	-20	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		4411	918	51	None	-20	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		616	918	51	None	-20	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		6976	918	51	None	-20	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		716121	918	51	None	-20	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL1201353	918	51	None	-20	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL1554789	918	51	None	-20	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL505	918	51	None	-20	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		DB01114	918	51	None	-20	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		DB13679	918	51	None	-20	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		135398745	2914	112	None	1	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	None	1	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	None	1	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	None	1	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		2267	559	71	None	10	7	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	None
		271	559	71	None	10	7	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	None
		7121	559	71	None	10	7	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	None
		CHEMBL639	559	71	None	10	7	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	None
		DB00972	559	71	None	10	7	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	None
		2726	919	68	None	-2	72	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	None	-2	72	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	None	-2	72	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	None	-2	72	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	None	-2	72	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		1613	2348	53	None	-3	44	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	2348	53	None	-3	44	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	2348	53	None	-3	44	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	2348	53	None	-3	44	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	2348	53	None	-3	44	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		135398745	2914	112	None	-2	65	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	None	-2	65	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	None	-2	65	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	None	-2	65	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		6834	205552	45	None	-1	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	5	0	2	3.9	CN(C)CCC(c1ccc(Br)cc1)c1ccccn1	None
		CHEMBL811	205552	45	None	-1	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	5	0	2	3.9	CN(C)CCC(c1ccc(Br)cc1)c1ccccn1	None
		4066	204626	78	None	-1	7	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	None
		CHEMBL73451	204626	78	None	-1	7	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	None
		115237	55585	119	None	-36	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		CHEMBL1621	55585	119	None	-36	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		25271818	12967	58	None	1	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	337	5	1	3	3.6	CN(C)CC/C=C1/c2ccccc2COc2ccc(CC(=O)O)cc21	None
		5281071	12967	58	None	1	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	337	5	1	3	3.6	CN(C)CC/C=C1/c2ccccc2COc2ccc(CC(=O)O)cc21	None
		CHEMBL1189432	12967	58	None	1	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	337	5	1	3	3.6	CN(C)CC/C=C1/c2ccccc2COc2ccc(CC(=O)O)cc21	None
		CHEMBL1719	12967	58	None	1	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	337	5	1	3	3.6	CN(C)CC/C=C1/c2ccccc2COc2ccc(CC(=O)O)cc21	None
		180	401	56	3H-MEPYRAMINE	-11	40	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		200	401	56	3H-MEPYRAMINE	-11	40	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2160	401	56	3H-MEPYRAMINE	-11	40	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL629	401	56	3H-MEPYRAMINE	-11	40	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		DB00321	401	56	3H-MEPYRAMINE	-11	40	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		209	3057	97	UNDEFINED	-11	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		2113	3057	97	UNDEFINED	-11	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		4748	3057	97	UNDEFINED	-11	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		CHEMBL567	3057	97	UNDEFINED	-11	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		DB00850	3057	97	UNDEFINED	-11	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		6726	1280	51	None	3	13	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		7151	1280	51	None	3	13	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		749	1280	51	None	3	13	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		CHEMBL648	1280	51	None	3	13	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		DB01176	1280	51	None	3	13	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		212	3806	47	None	-5	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		2639	3806	47	None	-5	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		941651	3806	47	None	-5	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		CHEMBL1201	3806	47	None	-5	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		DB01623	3806	47	None	-5	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		1971	2866	38	3H-doxepin	-1	30	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		2404	2866	38	3H-doxepin	-1	30	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		4543	2866	38	3H-doxepin	-1	30	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		CHEMBL445	2866	38	3H-doxepin	-1	30	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		DB00540	2866	38	3H-doxepin	-1	30	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		19861	207523	50	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	Drug Central	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	None
		CHEMBL946	207523	50	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandBinding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand	Drug Central	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	None
		135398737	958	93	None	-2	89	Guinea pig	8.1	pKi	=	8.1	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysisDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysis	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	None	-2	89	Guinea pig	8.1	pKi	=	8.1	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysisDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysis	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	None	-2	89	Guinea pig	8.1	pKi	=	8.1	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysisDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysis	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	None	-2	89	Guinea pig	8.1	pKi	=	8.1	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysisDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysis	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	None	-2	89	Guinea pig	8.1	pKi	=	8.1	Binding	Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysisDisplacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysis	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		11976	920	59	None	-4	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		667467	920	59	None	-4	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		CHEMBL908	920	59	None	-4	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		DB01239	920	59	None	-4	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsDisplacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		6075	150108	42	None	2	16	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	None
		CHEMBL395110	150108	42	None	2	16	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	None
		135398737	958	93	None	-4	89	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamineIn vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamine	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	None	-4	89	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamineIn vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamine	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	None	-4	89	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamineIn vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamine	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	None	-4	89	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamineIn vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamine	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	None	-4	89	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamineIn vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamine	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		26987	949	33	None	16	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		6063	949	33	None	16	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		671	949	33	None	16	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		CHEMBL1626	949	33	None	16	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		DB00283	949	33	None	16	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		1210	918	51	None	-9	21	Rat	8.1	pKi	=	8.1	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		1213	918	51	None	-9	21	Rat	8.1	pKi	=	8.1	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		2725	918	51	None	-9	21	Rat	8.1	pKi	=	8.1	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		33036	918	51	None	-9	21	Rat	8.1	pKi	=	8.1	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		4411	918	51	None	-9	21	Rat	8.1	pKi	=	8.1	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		616	918	51	None	-9	21	Rat	8.1	pKi	=	8.1	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		6976	918	51	None	-9	21	Rat	8.1	pKi	=	8.1	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		716121	918	51	None	-9	21	Rat	8.1	pKi	=	8.1	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL1201353	918	51	None	-9	21	Rat	8.1	pKi	=	8.1	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL1554789	918	51	None	-9	21	Rat	8.1	pKi	=	8.1	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL505	918	51	None	-9	21	Rat	8.1	pKi	=	8.1	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		DB01114	918	51	None	-9	21	Rat	8.1	pKi	=	8.1	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		DB13679	918	51	None	-9	21	Rat	8.1	pKi	=	8.1	Binding	Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranesAbility to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		1400	1957	70	None	2	3	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		3658	1957	70	None	2	3	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		7199	1957	70	None	2	3	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		91513	1957	70	None	2	3	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		CHEMBL896	1957	70	None	2	3	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		DB00557	1957	70	None	2	3	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	None
		2284	3182	33	None	1	29	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		4926	3182	33	None	1	29	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		7281	3182	33	None	1	29	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		CHEMBL564	3182	33	None	1	29	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		DB00420	3182	33	None	1	29	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		2600	3779	74	None	1	13	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		2608	3779	74	None	1	13	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		5405	3779	74	None	1	13	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		CHEMBL17157	3779	74	None	1	13	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		DB00342	3779	74	None	1	13	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		5284550	41721	15	None	-1	9	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	None
		CHEMBL1492500	41721	15	None	-1	9	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	None
		2337	3256	77	UNDEFINED	1	62	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	UNDEFINED	1	62	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	UNDEFINED	1	62	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	UNDEFINED	1	62	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	UNDEFINED	1	62	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		2337	3256	77	3H-PYRILAMINE	1	62	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	3H-PYRILAMINE	1	62	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	3H-PYRILAMINE	1	62	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	3H-PYRILAMINE	1	62	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	3H-PYRILAMINE	1	62	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		4098	32505	30	None	1	11	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	None
		CHEMBL1255739	32505	30	None	1	11	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	None
		CHEMBL1411979	32505	30	None	1	11	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	None
		1712	2492	43	None	1	22	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		4078	2492	43	None	1	22	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		7227	2492	43	None	1	22	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		CHEMBL1088	2492	43	None	1	22	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		DB00933	2492	43	None	1	22	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		1524	2181	96	None	-2	52	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	None	-2	52	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	None	-2	52	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	None	-2	52	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	None	-2	52	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	None	-2	52	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		4011	82408	49	None	6	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	None
		CHEMBL21731	82408	49	None	6	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	None
		1816	2540	102	None	-3	18	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		4205	2540	102	None	-3	18	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		7241	2540	102	None	-3	18	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		CHEMBL654	2540	102	None	-3	18	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		DB00370	2540	102	None	-3	18	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		2895	203592	41	None	-1	8	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	None
		CHEMBL669	203592	41	None	-1	8	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	None
		10102	2546	88	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	None
		1824	2546	88	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	None
		65906	2546	88	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	None
		CHEMBL94454	2546	88	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	None
		DB12523	2546	88	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	None
		5584	203211	44	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	294	4	0	2	4.1	CC(CN(C)C)CN1c2ccccc2CCc2ccccc21	None
		CHEMBL644	203211	44	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	294	4	0	2	4.1	CC(CN(C)C)CN1c2ccccc2CCc2ccccc21	None
		3219	199795	60	None	-	1	Human	8.1	pKi	=	8.1	Binding	Mechanism of ActionMechanism of Action	Drug Central	302	5	0	5	2.2	CCOCCn1c(N2CCCN(C)CC2)nc2ccccc21	None
		CHEMBL594	199795	60	None	-	1	Human	8.1	pKi	=	8.1	Binding	Mechanism of ActionMechanism of Action	Drug Central	302	5	0	5	2.2	CCOCCn1c(N2CCCN(C)CC2)nc2ccccc21	None
		2444	14478	26	None	1	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	333	6	0	2	4.1	CN(C)CCOC(c1ccccc1)c1ccc(Br)cc1	None
		CHEMBL1201245	14478	26	None	1	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	333	6	0	2	4.1	CN(C)CCOC(c1ccccc1)c1ccc(Br)cc1	None
		1027	1576	73	None	-6	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	None
		3241	1576	73	None	-6	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	None
		7176	1576	73	None	-6	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	None
		CHEMBL1106	1576	73	None	-6	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	None
		DB00751	1576	73	None	-6	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	None
		6761	67799	19	None	-1	18	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	None
		CHEMBL1909072	67799	19	None	-1	18	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	None
		1201549	597	24	None	-1	20	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		333	597	24	None	-1	20	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		7601	597	24	None	-1	20	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		CHEMBL1201203	597	24	None	-1	20	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		CHEMBL438151	597	24	None	-1	20	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		DB00245	597	24	None	-1	20	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		16667681	216153	0	3H-trans-H2-PAT,(-)	-4	3	Guinea pig	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	390	7	1	5	3.5	CN(C)CCCC1=CC=CC=N1.C1=CC(=CC=C1OC(=O)C=CC(=O)O)Cl	None
		1353	1911	93	3H-MEPYRAMINE	-213	83	Guinea pig	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-MEPYRAMINE	-213	83	Guinea pig	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-MEPYRAMINE	-213	83	Guinea pig	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-MEPYRAMINE	-213	83	Guinea pig	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-MEPYRAMINE	-213	83	Guinea pig	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		62857	216181	0	3H-PYRILAMINE	-12	7	Guinea pig	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	345	6	1	2	4.9	CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F.Cl	None
		24740862	148008	0	UNDEFINED	-4	5	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	369	6	1	5	4.4	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1F	None
		CHEMBL393436	148008	0	UNDEFINED	-4	5	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	369	6	1	5	4.4	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1F	None
		3033769	3281	61	3H-PYRILAMINE	-2344	19	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
		3033769	3281	61	3H-MEPYRAMINE	-2344	19	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
		3299	3281	61	3H-PYRILAMINE	-2344	19	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
		3299	3281	61	3H-MEPYRAMINE	-2344	19	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
		94	3281	61	3H-PYRILAMINE	-2344	19	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
		94	3281	61	3H-MEPYRAMINE	-2344	19	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
		CHEMBL8809	3281	61	3H-PYRILAMINE	-2344	19	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
		CHEMBL8809	3281	61	3H-MEPYRAMINE	-2344	19	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
		DB12518	3281	61	3H-PYRILAMINE	-2344	19	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
		DB12518	3281	61	3H-MEPYRAMINE	-2344	19	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
		13091268	78224	0	UNDEFINED	-9549	14	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	401	6	1	3	5.0	O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1	None
		CHEMBL210578	78224	0	UNDEFINED	-9549	14	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	401	6	1	3	5.0	O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1	None
		2389	3331	118	UNDEFINED	-346	67	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	UNDEFINED	-346	67	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	UNDEFINED	-346	67	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	UNDEFINED	-346	67	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	UNDEFINED	-346	67	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		2995	204405	53	3H-Histamine	-42	23	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL1696	204405	53	3H-Histamine	-42	23	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL72	204405	53	3H-Histamine	-42	23	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		46780481	107531	20	None	-13	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		9903970	107531	20	None	-13	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3187365	107531	20	None	-13	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3544974	107531	20	None	-13	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		2726	919	68	3H-MEPYRAMINE	-2	72	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		2726	919	68	3H-doxepin	-2	72	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	3H-MEPYRAMINE	-2	72	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	3H-doxepin	-2	72	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	3H-MEPYRAMINE	-2	72	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	3H-doxepin	-2	72	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	3H-MEPYRAMINE	-2	72	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	3H-doxepin	-2	72	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	3H-MEPYRAMINE	-2	72	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	3H-doxepin	-2	72	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		2710	84308	31	3H-MEPYRAMINE	-1	3	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	300	3	0	2	3.7	CN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	None
		CHEMBL22150	84308	31	3H-MEPYRAMINE	-1	3	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	300	3	0	2	3.7	CN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	None
		135	2532	43	None	-1	58	Guinea pig	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	None	-1	58	Guinea pig	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	None	-1	58	Guinea pig	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	None	-1	58	Guinea pig	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	None	-1	58	Guinea pig	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		2726	919	68	UNDEFINED	-2	72	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	UNDEFINED	-2	72	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	UNDEFINED	-2	72	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	UNDEFINED	-2	72	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	UNDEFINED	-2	72	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		1227	2489	43	None	-2	12	Human	8.0	pKi	=	8.0	Binding	GRAC: human H1 selective antagonistGRAC: human H1 selective antagonist	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		2331	2489	43	None	-2	12	Human	8.0	pKi	=	8.0	Binding	GRAC: human H1 selective antagonistGRAC: human H1 selective antagonist	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		3957	2489	43	None	-2	12	Human	8.0	pKi	=	8.0	Binding	GRAC: human H1 selective antagonistGRAC: human H1 selective antagonist	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		4992	2489	43	None	-2	12	Human	8.0	pKi	=	8.0	Binding	GRAC: human H1 selective antagonistGRAC: human H1 selective antagonist	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		CHEMBL511	2489	43	None	-2	12	Human	8.0	pKi	=	8.0	Binding	GRAC: human H1 selective antagonistGRAC: human H1 selective antagonist	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		DB06691	2489	43	None	-2	12	Human	8.0	pKi	=	8.0	Binding	GRAC: human H1 selective antagonistGRAC: human H1 selective antagonist	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		1228	3866	34	3H-MEPYRAMINE	-10	4	Mouse	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		2763	3866	34	3H-MEPYRAMINE	-10	4	Mouse	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		5282443	3866	34	3H-MEPYRAMINE	-10	4	Mouse	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		CHEMBL855	3866	34	3H-MEPYRAMINE	-10	4	Mouse	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		DB00427	3866	34	3H-MEPYRAMINE	-10	4	Mouse	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		1210	918	51	None	-20	21	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		1213	918	51	None	-20	21	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		2725	918	51	None	-20	21	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		33036	918	51	None	-20	21	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		4411	918	51	None	-20	21	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		616	918	51	None	-20	21	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		6976	918	51	None	-20	21	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		716121	918	51	None	-20	21	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL1201353	918	51	None	-20	21	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL1554789	918	51	None	-20	21	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL505	918	51	None	-20	21	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		DB01114	918	51	None	-20	21	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		DB13679	918	51	None	-20	21	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		21855	84246	42	None	7	6	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	None
		CHEMBL22108	84246	42	None	7	6	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	None
		135398737	958	93	None	2	89	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	None	2	89	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	None	2	89	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	None	2	89	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	None	2	89	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		1224	1432	83	3H-MEPYRAMINE	1	13	Guinea pig	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		3100	1432	83	3H-MEPYRAMINE	1	13	Guinea pig	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		8980	1432	83	3H-MEPYRAMINE	1	13	Guinea pig	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		916	1432	83	3H-MEPYRAMINE	1	13	Guinea pig	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		CHEMBL657	1432	83	3H-MEPYRAMINE	1	13	Guinea pig	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		DB01075	1432	83	3H-MEPYRAMINE	1	13	Guinea pig	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		103	4153	61	None	-1	53	Human	8.0	pKi	=	8.0	Binding	Binding affinity towards human H1 receptorBinding affinity towards human H1 receptor	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	4153	61	None	-1	53	Human	8.0	pKi	=	8.0	Binding	Binding affinity towards human H1 receptorBinding affinity towards human H1 receptor	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	4153	61	None	-1	53	Human	8.0	pKi	=	8.0	Binding	Binding affinity towards human H1 receptorBinding affinity towards human H1 receptor	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	4153	61	None	-1	53	Human	8.0	pKi	=	8.0	Binding	Binding affinity towards human H1 receptorBinding affinity towards human H1 receptor	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	4153	61	None	-1	53	Human	8.0	pKi	=	8.0	Binding	Binding affinity towards human H1 receptorBinding affinity towards human H1 receptor	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		135	2532	43	None	-1	58	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	None	-1	58	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	None	-1	58	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	None	-1	58	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	None	-1	58	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		72287	61061	38	None	6	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	328	5	0	4	4.5	COc1ccc2c(c1)N(C[C@H](C)CN(C)C)c1ccccc1S2	None
		CHEMBL1764	61061	38	None	6	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	328	5	0	4	4.5	COc1ccc2c(c1)N(C[C@H](C)CN(C)C)c1ccccc1S2	None
		2435	3590	83	None	-95	48	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsDisplacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cells	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		60149	3590	83	None	-95	48	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsDisplacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cells	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		98	3590	83	None	-95	48	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsDisplacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cells	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		CHEMBL12713	3590	83	None	-95	48	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsDisplacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cells	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		DB06144	3590	83	None	-95	48	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsDisplacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cells	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		180	401	56	None	-1	40	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		200	401	56	None	-1	40	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2160	401	56	None	-1	40	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL629	401	56	None	-1	40	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		DB00321	401	56	None	-1	40	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		62865	1274	0	3H-PYRILAMINE	-3	14	Guinea pig	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		746	1274	0	3H-PYRILAMINE	-3	14	Guinea pig	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		84	1274	0	3H-PYRILAMINE	-3	14	Guinea pig	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		CHEMBL2104153	1274	0	3H-PYRILAMINE	-3	14	Guinea pig	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		DB09000	1274	0	3H-PYRILAMINE	-3	14	Guinea pig	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		46780481	107531	20	3H-PYRILAMINE	-13	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		9903970	107531	20	3H-PYRILAMINE	-13	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3187365	107531	20	3H-PYRILAMINE	-13	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3544974	107531	20	3H-PYRILAMINE	-13	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		None	215992	0	3H-MEPYRAMINE	1	11	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	522	10	0	3	6.2	C1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F.Cl.Cl	None
		124087	1389	114	None	3	15	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
		7157	1389	114	None	3	15	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
		814	1389	114	None	3	15	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
		CHEMBL1172	1389	114	None	3	15	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
		DB00967	1389	114	None	3	15	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
		1530	2182	50	None	-5	21	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		3827	2182	50	None	-5	21	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		7206	2182	50	None	-5	21	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		CHEMBL534	2182	50	None	-5	21	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		DB00920	2182	50	None	-5	21	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		1530	2182	50	None	5	21	Guinea pig	8.0	pKi	=	8.0	Binding	The compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMThe compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		3827	2182	50	None	5	21	Guinea pig	8.0	pKi	=	8.0	Binding	The compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMThe compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		7206	2182	50	None	5	21	Guinea pig	8.0	pKi	=	8.0	Binding	The compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMThe compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		CHEMBL534	2182	50	None	5	21	Guinea pig	8.0	pKi	=	8.0	Binding	The compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMThe compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		DB00920	2182	50	None	5	21	Guinea pig	8.0	pKi	=	8.0	Binding	The compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMThe compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		135398745	2914	112	None	-1	65	Rat	8.0	pKi	=	8.0	Binding	Half-maximal inhibition of [3H]7-OH-DPAT binding to Histamine H1 receptor in rat tissue homogenateHalf-maximal inhibition of [3H]7-OH-DPAT binding to Histamine H1 receptor in rat tissue homogenate	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	None	-1	65	Rat	8.0	pKi	=	8.0	Binding	Half-maximal inhibition of [3H]7-OH-DPAT binding to Histamine H1 receptor in rat tissue homogenateHalf-maximal inhibition of [3H]7-OH-DPAT binding to Histamine H1 receptor in rat tissue homogenate	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	None	-1	65	Rat	8.0	pKi	=	8.0	Binding	Half-maximal inhibition of [3H]7-OH-DPAT binding to Histamine H1 receptor in rat tissue homogenateHalf-maximal inhibition of [3H]7-OH-DPAT binding to Histamine H1 receptor in rat tissue homogenate	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	None	-1	65	Rat	8.0	pKi	=	8.0	Binding	Half-maximal inhibition of [3H]7-OH-DPAT binding to Histamine H1 receptor in rat tissue homogenateHalf-maximal inhibition of [3H]7-OH-DPAT binding to Histamine H1 receptor in rat tissue homogenate	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		1224	1432	83	3H-trans-H2-PAT,(-)	1	13	Guinea pig	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		1224	1432	83	3H-MEPYRAMINE	-2	13	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		3100	1432	83	3H-trans-H2-PAT,(-)	1	13	Guinea pig	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		3100	1432	83	3H-MEPYRAMINE	-2	13	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		8980	1432	83	3H-trans-H2-PAT,(-)	1	13	Guinea pig	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		8980	1432	83	3H-MEPYRAMINE	-2	13	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		916	1432	83	3H-trans-H2-PAT,(-)	1	13	Guinea pig	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		916	1432	83	3H-MEPYRAMINE	-2	13	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		CHEMBL657	1432	83	3H-trans-H2-PAT,(-)	1	13	Guinea pig	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		CHEMBL657	1432	83	3H-MEPYRAMINE	-2	13	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		DB01075	1432	83	3H-trans-H2-PAT,(-)	1	13	Guinea pig	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		DB01075	1432	83	3H-MEPYRAMINE	-2	13	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		2286	3183	51	None	-2	30	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		4927	3183	51	None	-2	30	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		7282	3183	51	None	-2	30	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		CHEMBL643	3183	51	None	-2	30	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		DB01069	3183	51	None	-2	30	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		1238	203174	24	None	-38	16	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsDisplacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cells	Drug Central	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
		CHEMBL64249	203174	24	None	-38	16	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsDisplacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cells	Drug Central	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
		1225	1471	26	None	-1	22	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		3958	1471	26	None	-1	22	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		667477	1471	26	None	-1	22	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		CHEMBL860	1471	26	None	-1	22	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		DB01142	1471	26	None	-1	22	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		1228	3866	34	None	-5	4	Human	8.0	pKi	=	8	Binding	GRAC: human H1 selective antagonistGRAC: human H1 selective antagonist	Drug Central	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		2763	3866	34	None	-5	4	Human	8.0	pKi	=	8	Binding	GRAC: human H1 selective antagonistGRAC: human H1 selective antagonist	Drug Central	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		5282443	3866	34	None	-5	4	Human	8.0	pKi	=	8	Binding	GRAC: human H1 selective antagonistGRAC: human H1 selective antagonist	Drug Central	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		CHEMBL855	3866	34	None	-5	4	Human	8.0	pKi	=	8	Binding	GRAC: human H1 selective antagonistGRAC: human H1 selective antagonist	Drug Central	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		DB00427	3866	34	None	-5	4	Human	8.0	pKi	=	8	Binding	GRAC: human H1 selective antagonistGRAC: human H1 selective antagonist	Drug Central	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	None
		134	2514	24	3H-MEPYRAMINE	-933	67	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	3H-MEPYRAMINE	-933	67	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	3H-MEPYRAMINE	-933	67	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	3H-MEPYRAMINE	-933	67	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	3H-MEPYRAMINE	-933	67	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		114743	216101	0	3H-PYRILAMINE	-5	8	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	291	1	1	1	4.9	C1CC(C2=CC=CC=C2C1C3=CC(=C(C=C3)Cl)Cl)N	None
		10065083	32103	1	UNDEFINED	-141	10	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	328	6	0	5	2.4	O=C(CCCN1CCN(c2ncccn2)CC1)c1ccc(F)cc1	None
		CHEMBL140872	32103	1	UNDEFINED	-141	10	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	328	6	0	5	2.4	O=C(CCCN1CCN(c2ncccn2)CC1)c1ccc(F)cc1	None
		46882133	5808	0	UNDEFINED	-5	7	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	478	9	2	7	5.1	CCOc1cc(CN2CCC(Nc3nc4cc(NC(=O)C5CCC5)ccc4o3)CC2)ccc1OC	None
		CHEMBL1078896	5808	0	UNDEFINED	-5	7	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	478	9	2	7	5.1	CCOc1cc(CN2CCC(Nc3nc4cc(NC(=O)C5CCC5)ccc4o3)CC2)ccc1OC	None
		1209	1658	75	3H-PYRILAMINE	-223	32	Guinea pig	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		203	1658	75	3H-PYRILAMINE	-223	32	Guinea pig	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		3386	1658	75	3H-PYRILAMINE	-223	32	Guinea pig	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		CHEMBL41	1658	75	3H-PYRILAMINE	-223	32	Guinea pig	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		DB00472	1658	75	3H-PYRILAMINE	-223	32	Guinea pig	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		44350664	118149	0	UNDEFINED	-9	6	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	351	6	0	2	5.2	O=C(CCCN1C2CCC1CC(c1ccccc1)C2)c1ccc(F)cc1	None
		CHEMBL340816	118149	0	UNDEFINED	-9	6	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	351	6	0	2	5.2	O=C(CCCN1C2CCC1CC(c1ccccc1)C2)c1ccc(F)cc1	None
		CHEMBL553417	118149	0	UNDEFINED	-9	6	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	351	6	0	2	5.2	O=C(CCCN1C2CCC1CC(c1ccccc1)C2)c1ccc(F)cc1	None
		16667681	216153	0	3H-MEPYRAMINE	-4	3	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	390	7	1	5	3.5	CN(C)CCCC1=CC=CC=N1.C1=CC(=CC=C1OC(=O)C=CC(=O)O)Cl	None
		1204	1932	119	3H-trans-H2-PAT,(-)	-46	24	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	3H-trans-H2-PAT,(-)	-46	24	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	3H-trans-H2-PAT,(-)	-46	24	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	3H-trans-H2-PAT,(-)	-46	24	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	3H-trans-H2-PAT,(-)	-46	24	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	3H-trans-H2-PAT,(-)	-46	24	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		180	401	56	None	-1	40	Human	9.3	pKi	=	9.3	Binding	Antagonism of [<sup>3</sup>H]mepyramine bindingAntagonism of [<sup>3</sup>H]mepyramine binding	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	16782354
		200	401	56	None	-1	40	Human	9.3	pKi	=	9.3	Binding	Antagonism of [<sup>3</sup>H]mepyramine bindingAntagonism of [<sup>3</sup>H]mepyramine binding	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	16782354
		2160	401	56	None	-1	40	Human	9.3	pKi	=	9.3	Binding	Antagonism of [<sup>3</sup>H]mepyramine bindingAntagonism of [<sup>3</sup>H]mepyramine binding	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	16782354
		CHEMBL629	401	56	None	-1	40	Human	9.3	pKi	=	9.3	Binding	Antagonism of [<sup>3</sup>H]mepyramine bindingAntagonism of [<sup>3</sup>H]mepyramine binding	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	16782354
		DB00321	401	56	None	-1	40	Human	9.3	pKi	=	9.3	Binding	Antagonism of [<sup>3</sup>H]mepyramine bindingAntagonism of [<sup>3</sup>H]mepyramine binding	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	16782354
		11753159	547	6	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Assayed using the sodium salt of the compoundAssayed using the sodium salt of the compound	Guide to Pharmacology	525	5	1	5	4.7	Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl	23031591
		7679	547	6	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Assayed using the sodium salt of the compoundAssayed using the sodium salt of the compound	Guide to Pharmacology	525	5	1	5	4.7	Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl	23031591
		CHEMBL2158814	547	6	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Assayed using the sodium salt of the compoundAssayed using the sodium salt of the compound	Guide to Pharmacology	525	5	1	5	4.7	Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl	23031591
		11579	635	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding to human recombinant histamine H<sub>1</sub> receptorsBinding to human recombinant histamine H<sub>1</sub> receptors	Guide to Pharmacology	463	10	1	5	4.9	CCOCCn1c(nc2c1cccc2)C1CCN(CC1)CCc1ccc(cc1)C(C(=O)O)(C)C	16274260
		185460	635	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding to human recombinant histamine H<sub>1</sub> receptorsBinding to human recombinant histamine H<sub>1</sub> receptors	Guide to Pharmacology	463	10	1	5	4.9	CCOCCn1c(nc2c1cccc2)C1CCN(CC1)CCc1ccc(cc1)C(C(=O)O)(C)C	16274260
		CHEMBL1742423	635	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding to human recombinant histamine H<sub>1</sub> receptorsBinding to human recombinant histamine H<sub>1</sub> receptors	Guide to Pharmacology	463	10	1	5	4.9	CCOCCn1c(nc2c1cccc2)C1CCN(CC1)CCc1ccc(cc1)C(C(=O)O)(C)C	16274260
		DB11591	635	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding to human recombinant histamine H<sub>1</sub> receptorsBinding to human recombinant histamine H<sub>1</sub> receptors	Guide to Pharmacology	463	10	1	5	4.9	CCOCCn1c(nc2c1cccc2)C1CCN(CC1)CCc1ccc(cc1)C(C(=O)O)(C)C	16274260
		2749	344	40	None	1	2	Bovine	9.1	pKi	=	9.1	Binding	Inhibition of [<sup>3</sup>H]mepyramine binding to bovine brain membrane preparations <i>in vitro</i>.Inhibition of [<sup>3</sup>H]mepyramine binding to bovine brain membrane preparations <i>in vitro</i>.	Guide to Pharmacology	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	2884340
		5574	344	40	None	1	2	Bovine	9.1	pKi	=	9.1	Binding	Inhibition of [<sup>3</sup>H]mepyramine binding to bovine brain membrane preparations <i>in vitro</i>.Inhibition of [<sup>3</sup>H]mepyramine binding to bovine brain membrane preparations <i>in vitro</i>.	Guide to Pharmacology	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	2884340
		7237	344	40	None	1	2	Bovine	9.1	pKi	=	9.1	Binding	Inhibition of [<sup>3</sup>H]mepyramine binding to bovine brain membrane preparations <i>in vitro</i>.Inhibition of [<sup>3</sup>H]mepyramine binding to bovine brain membrane preparations <i>in vitro</i>.	Guide to Pharmacology	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	2884340
		CHEMBL829	344	40	None	1	2	Bovine	9.1	pKi	=	9.1	Binding	Inhibition of [<sup>3</sup>H]mepyramine binding to bovine brain membrane preparations <i>in vitro</i>.Inhibition of [<sup>3</sup>H]mepyramine binding to bovine brain membrane preparations <i>in vitro</i>.	Guide to Pharmacology	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	2884340
		DB01246	344	40	None	1	2	Bovine	9.1	pKi	=	9.1	Binding	Inhibition of [<sup>3</sup>H]mepyramine binding to bovine brain membrane preparations <i>in vitro</i>.Inhibition of [<sup>3</sup>H]mepyramine binding to bovine brain membrane preparations <i>in vitro</i>.	Guide to Pharmacology	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	2884340
		10102	2546	88	None	-	1	Human	8.6	pKi	=	8.6	Binding	Radioligand displacement membrane binding assay using CHO cells expressing the human H1 receptor and [3H]pyrilamine as tracer.Radioligand displacement membrane binding assay using CHO cells expressing the human H1 receptor and [3H]pyrilamine as tracer.	Guide to Pharmacology	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	19553115
		1824	2546	88	None	-	1	Human	8.6	pKi	=	8.6	Binding	Radioligand displacement membrane binding assay using CHO cells expressing the human H1 receptor and [3H]pyrilamine as tracer.Radioligand displacement membrane binding assay using CHO cells expressing the human H1 receptor and [3H]pyrilamine as tracer.	Guide to Pharmacology	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	19553115
		65906	2546	88	None	-	1	Human	8.6	pKi	=	8.6	Binding	Radioligand displacement membrane binding assay using CHO cells expressing the human H1 receptor and [3H]pyrilamine as tracer.Radioligand displacement membrane binding assay using CHO cells expressing the human H1 receptor and [3H]pyrilamine as tracer.	Guide to Pharmacology	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	19553115
		CHEMBL94454	2546	88	None	-	1	Human	8.6	pKi	=	8.6	Binding	Radioligand displacement membrane binding assay using CHO cells expressing the human H1 receptor and [3H]pyrilamine as tracer.Radioligand displacement membrane binding assay using CHO cells expressing the human H1 receptor and [3H]pyrilamine as tracer.	Guide to Pharmacology	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	19553115
		DB12523	2546	88	None	-	1	Human	8.6	pKi	=	8.6	Binding	Radioligand displacement membrane binding assay using CHO cells expressing the human H1 receptor and [3H]pyrilamine as tracer.Radioligand displacement membrane binding assay using CHO cells expressing the human H1 receptor and [3H]pyrilamine as tracer.	Guide to Pharmacology	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	19553115
		277	1301	62	None	-2	50	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	7925364
		2913	1301	62	None	-2	50	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	7925364
		765	1301	62	None	-2	50	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	7925364
		CHEMBL516	1301	62	None	-2	50	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	7925364
		DB00434	1301	62	None	-2	50	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	7925364
		26987	949	33	None	16	21	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		6063	949	33	None	16	21	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		671	949	33	None	16	21	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		CHEMBL1626	949	33	None	16	21	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		DB00283	949	33	None	16	21	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		10447834	1933	4	None	-1862	5	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	15947036
		4026	1933	4	None	-1862	5	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	15947036
		CHEMBL275507	1933	4	None	-1862	5	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	7	2	2	3.7	NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	15947036
		5048	3133	64	None	-109	7	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	26084539
		8924	3133	64	None	-109	7	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	26084539
		9948102	3133	64	None	-109	7	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	26084539
		CHEMBL462605	3133	64	None	-109	7	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	26084539
		DB11642	3133	64	None	-109	7	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	26084539
		10403687	2511	3	None	-331	5	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	12626648
		1205	2511	3	None	-331	5	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	12626648
		CHEMBL275035	2511	3	None	-331	5	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	319	8	2	2	3.9	CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1	12626648
		1210	918	51	None	-20	21	Human	6.6	pKi	=	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	12065734
		1213	918	51	None	-20	21	Human	6.6	pKi	=	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	12065734
		2725	918	51	None	-20	21	Human	6.6	pKi	=	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	12065734
		33036	918	51	None	-20	21	Human	6.6	pKi	=	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	12065734
		4411	918	51	None	-20	21	Human	6.6	pKi	=	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	12065734
		616	918	51	None	-20	21	Human	6.6	pKi	=	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	12065734
		6976	918	51	None	-20	21	Human	6.6	pKi	=	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	12065734
		716121	918	51	None	-20	21	Human	6.6	pKi	=	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	12065734
		CHEMBL1201353	918	51	None	-20	21	Human	6.6	pKi	=	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	12065734
		CHEMBL1554789	918	51	None	-20	21	Human	6.6	pKi	=	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	12065734
		CHEMBL505	918	51	None	-20	21	Human	6.6	pKi	=	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	12065734
		DB01114	918	51	None	-20	21	Human	6.6	pKi	=	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	12065734
		DB13679	918	51	None	-20	21	Human	6.6	pKi	=	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	12065734
		1215	2083	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)[C@H](c1ccc(cc1)Cl)c1ccccc1	15206929
		150716	2083	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)[C@H](c1ccc(cc1)Cl)c1ccccc1	15206929
		28145930	2083	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)[C@H](c1ccc(cc1)Cl)c1ccccc1	15206929
		CHEMBL1334217	2083	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)[C@H](c1ccc(cc1)Cl)c1ccccc1	15206929
		10104	3566	12	None	-2	6	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	0	2	4.1	CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C	12593665
		6604866	3566	12	None	-2	6	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	0	2	4.1	CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C	12593665
		CHEMBL1493369	3566	12	None	-2	6	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	0	2	4.1	CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C	12593665
		2600	3779	74	None	1	13	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	19660947
		2608	3779	74	None	1	13	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	19660947
		5405	3779	74	None	1	13	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	19660947
		CHEMBL17157	3779	74	None	1	13	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	19660947
		DB00342	3779	74	None	1	13	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	19660947
		1605	2342	117	None	-2	4	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	15771458
		3957	2342	117	None	-2	4	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	15771458
		7216	2342	117	None	-2	4	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	15771458
		CHEMBL998	2342	117	None	-2	4	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	15771458
		DB00455	2342	117	None	-2	4	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	15771458
		1170	1633	75	None	-	1	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	19660947
		3348	1633	75	None	-	1	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	19660947
		4819	1633	75	None	-	1	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	19660947
		74685737	1633	75	None	-	1	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	19660947
		CHEMBL914	1633	75	None	-	1	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	19660947
		DB00950	1633	75	None	-	1	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	19660947
		1224	1432	83	None	-2	13	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	12065734
		3100	1432	83	None	-2	13	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	12065734
		8980	1432	83	None	-2	13	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	12065734
		916	1432	83	None	-2	13	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	12065734
		CHEMBL657	1432	83	None	-2	13	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	12065734
		DB01075	1432	83	None	-2	13	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	12065734
		1210	918	51	None	-20	21	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	21381763
		1213	918	51	None	-20	21	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	21381763
		2725	918	51	None	-20	21	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	21381763
		33036	918	51	None	-20	21	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	21381763
		4411	918	51	None	-20	21	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	21381763
		616	918	51	None	-20	21	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	21381763
		6976	918	51	None	-20	21	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	21381763
		716121	918	51	None	-20	21	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	21381763
		CHEMBL1201353	918	51	None	-20	21	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	21381763
		CHEMBL1554789	918	51	None	-20	21	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	21381763
		CHEMBL505	918	51	None	-20	21	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	21381763
		DB01114	918	51	None	-20	21	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	21381763
		DB13679	918	51	None	-20	21	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	21381763
		1222	881	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	7925364
		2678	881	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	7925364
		581	881	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	7925364
		CHEMBL1000	881	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	7925364
		DB00341	881	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	7925364
		6726	1280	51	None	3	13	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		7151	1280	51	None	3	13	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		749	1280	51	None	3	13	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		CHEMBL648	1280	51	None	3	13	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		DB01176	1280	51	None	3	13	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		5282426	1466	0	None	4	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	3	0	2	4.7	CN(CC/C=C/1\c2ccccc2SCc2c1cccc2)C	10379421
		7549	1466	0	None	4	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	3	0	2	4.7	CN(CC/C=C/1\c2ccccc2SCc2c1cccc2)C	10379421
		CHEMBL108947	1466	0	None	4	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	3	0	2	4.7	CN(CC/C=C/1\c2ccccc2SCc2c1cccc2)C	10379421
		11976	920	59	None	-4	24	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	19091563
		667467	920	59	None	-4	24	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	19091563
		CHEMBL908	920	59	None	-4	24	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	19091563
		DB01239	920	59	None	-4	24	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	19091563
		1210	918	51	None	-20	21	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	12065734
		1210	918	51	None	-20	21	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	7925364
		1213	918	51	None	-20	21	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	12065734
		1213	918	51	None	-20	21	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	7925364
		2725	918	51	None	-20	21	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	12065734
		2725	918	51	None	-20	21	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	7925364
		33036	918	51	None	-20	21	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	12065734
		33036	918	51	None	-20	21	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	7925364
		4411	918	51	None	-20	21	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	12065734
		4411	918	51	None	-20	21	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	7925364
		616	918	51	None	-20	21	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	12065734
		616	918	51	None	-20	21	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	7925364
		6976	918	51	None	-20	21	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	12065734
		6976	918	51	None	-20	21	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	7925364
		716121	918	51	None	-20	21	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	12065734
		716121	918	51	None	-20	21	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	7925364
		CHEMBL1201353	918	51	None	-20	21	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	12065734
		CHEMBL1201353	918	51	None	-20	21	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	7925364
		CHEMBL1554789	918	51	None	-20	21	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	12065734
		CHEMBL1554789	918	51	None	-20	21	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	7925364
		CHEMBL505	918	51	None	-20	21	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	12065734
		CHEMBL505	918	51	None	-20	21	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	7925364
		DB01114	918	51	None	-20	21	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	12065734
		DB01114	918	51	None	-20	21	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	7925364
		DB13679	918	51	None	-20	21	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	12065734
		DB13679	918	51	None	-20	21	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	7925364
		1214	2068	54	None	-	1	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1	15206929
		1549000	2068	54	None	-	1	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1	15206929
		1566	2068	54	None	-	1	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1	15206929
		28145931	2068	54	None	-	1	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1	15206929
		CHEMBL1201191	2068	54	None	-	1	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1	15206929
		DB06282	2068	54	None	-	1	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1	15206929
		2247	505	81	None	-4	42	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	12747773
		249	505	81	None	-4	42	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	12747773
		2603	505	81	None	-4	42	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	12747773
		CHEMBL296419	505	81	None	-4	42	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	12747773
		DB00637	505	81	None	-4	42	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	12747773
		1530	2182	50	None	-5	21	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	21470866
		3827	2182	50	None	-5	21	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	21470866
		7206	2182	50	None	-5	21	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	21470866
		CHEMBL534	2182	50	None	-5	21	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	21470866
		DB00920	2182	50	None	-5	21	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	21470866
		1400	1957	70	None	2	3	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	11809864
		3658	1957	70	None	2	3	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	11809864
		7199	1957	70	None	2	3	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	11809864
		91513	1957	70	None	2	3	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	11809864
		CHEMBL896	1957	70	None	2	3	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	11809864
		DB00557	1957	70	None	2	3	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	11809864
		1228	3866	34	None	-5	4	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	12065734
		1228	3866	34	None	-5	4	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	7925364
		2763	3866	34	None	-5	4	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	12065734
		2763	3866	34	None	-5	4	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	7925364
		5282443	3866	34	None	-5	4	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	12065734
		5282443	3866	34	None	-5	4	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	7925364
		CHEMBL855	3866	34	None	-5	4	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	12065734
		CHEMBL855	3866	34	None	-5	4	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	7925364
		DB00427	3866	34	None	-5	4	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	12065734
		DB00427	3866	34	None	-5	4	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	278	4	0	2	3.9	Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1	7925364
		1227	2489	43	None	-2	12	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	12065734
		1227	2489	43	None	-2	12	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	15206929
		2331	2489	43	None	-2	12	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	12065734
		2331	2489	43	None	-2	12	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	15206929
		3957	2489	43	None	-2	12	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	12065734
		3957	2489	43	None	-2	12	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	15206929
		4992	2489	43	None	-2	12	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	12065734
		4992	2489	43	None	-2	12	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	15206929
		CHEMBL511	2489	43	None	-2	12	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	12065734
		CHEMBL511	2489	43	None	-2	12	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	15206929
		DB06691	2489	43	None	-2	12	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	12065734
		DB06691	2489	43	None	-2	12	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	15206929
		2267	559	71	None	10	7	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	21381763
		271	559	71	None	10	7	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	21381763
		7121	559	71	None	10	7	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	21381763
		CHEMBL639	559	71	None	10	7	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	21381763
		DB00972	559	71	None	10	7	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	21381763
		124087	1389	114	None	3	15	Human	9.0	pKi	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	15482930
		7157	1389	114	None	3	15	Human	9.0	pKi	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	15482930
		814	1389	114	None	3	15	Human	9.0	pKi	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	15482930
		CHEMBL1172	1389	114	None	3	15	Human	9.0	pKi	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	15482930
		DB00967	1389	114	None	3	15	Human	9.0	pKi	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	15482930
		2286	3183	51	None	-2	30	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	16782354
		4927	3183	51	None	-2	30	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	16782354
		7282	3183	51	None	-2	30	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	16782354
		CHEMBL643	3183	51	None	-2	30	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	16782354
		DB01069	3183	51	None	-2	30	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	16782354
		10103	3416	72	None	-25	3	Guinea pig	7.0	pKi	=	7	Binding	[3H]-pyrilamine binding to guinea pig cerebellum membranes.[3H]-pyrilamine binding to guinea pig cerebellum membranes.	Guide to Pharmacology	415	2	0	3	5.6	Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	8996188
		133017	3416	72	None	-25	3	Guinea pig	7.0	pKi	=	7	Binding	[3H]-pyrilamine binding to guinea pig cerebellum membranes.[3H]-pyrilamine binding to guinea pig cerebellum membranes.	Guide to Pharmacology	415	2	0	3	5.6	Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	8996188
		2413	3416	72	None	-25	3	Guinea pig	7.0	pKi	=	7	Binding	[3H]-pyrilamine binding to guinea pig cerebellum membranes.[3H]-pyrilamine binding to guinea pig cerebellum membranes.	Guide to Pharmacology	415	2	0	3	5.6	Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	8996188
		CHEMBL91397	3416	72	None	-25	3	Guinea pig	7.0	pKi	=	7	Binding	[3H]-pyrilamine binding to guinea pig cerebellum membranes.[3H]-pyrilamine binding to guinea pig cerebellum membranes.	Guide to Pharmacology	415	2	0	3	5.6	Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	8996188
		DB11614	3416	72	None	-25	3	Guinea pig	7.0	pKi	=	7	Binding	[3H]-pyrilamine binding to guinea pig cerebellum membranes.[3H]-pyrilamine binding to guinea pig cerebellum membranes.	Guide to Pharmacology	415	2	0	3	5.6	Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	8996188
		1265	942	60	None	-17782	8	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	26084539
		6422124	942	60	None	-17782	8	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	26084539
		CHEMBL14638	942	60	None	-17782	8	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	26084539
		441082	1163	48	None	-2137	8	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	1	0	2	4.8	CN([C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]24[C@H]3CC[C@@H]4[C@@H](N(C2)C)C)C1)C)C	26084539
		8981	1163	48	None	-2137	8	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	1	0	2	4.8	CN([C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]24[C@H]3CC[C@@H]4[C@@H](N(C2)C)C)C1)C)C	26084539
		CHEMBL191703	1163	48	None	-2137	8	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	1	0	2	4.8	CN([C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]24[C@H]3CC[C@@H]4[C@@H](N(C2)C)C)C1)C)C	26084539
		117072554	2023	0	None	-1995	4	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	450	5	2	6	2.3	CN1CCN(CC1)C1=CC(=NC(N1)N)c1ccc2c(c1)CN(CC2)C(=O)CCC1CCCC1	26084539
		8982	2023	0	None	-1995	4	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	450	5	2	6	2.3	CN1CCN(CC1)C1=CC(=NC(N1)N)c1ccc2c(c1)CN(CC2)C(=O)CCC1CCCC1	26084539
		11697697	2547	24	None	-6309	6	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	431	6	0	5	4.6	Cc1nc2cccc(c2c(=O)n1c1ccc(cc1)OCCCN1CCCC1)C(F)(F)F	26084539
		7346	2547	24	None	-6309	6	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	431	6	0	5	4.6	Cc1nc2cccc(c2c(=O)n1c1ccc(cc1)OCCCN1CCCC1)C(F)(F)F	26084539
		CHEMBL476323	2547	24	None	-6309	6	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	431	6	0	5	4.6	Cc1nc2cccc(c2c(=O)n1c1ccc(cc1)OCCCN1CCCC1)C(F)(F)F	26084539
		DB11910	2547	24	None	-6309	6	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	431	6	0	5	4.6	Cc1nc2cccc(c2c(=O)n1c1ccc(cc1)OCCCN1CCCC1)C(F)(F)F	26084539
		24994634	2142	31	None	-194	7	Human	6.0	pKi	>	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	26084539
		8984	2142	31	None	-194	7	Human	6.0	pKi	>	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	26084539
		CHEMBL3236549	2142	31	None	-194	7	Human	6.0	pKi	>	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	221	2	2	5	0.7	N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C	26084539
		45257132	3682	10	None	-83	4	Human	6.0	pKi	>	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	366	4	2	6	2.7	CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(n1)N	26084539
		8983	3682	10	None	-83	4	Human	6.0	pKi	>	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	366	4	2	6	2.7	CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(n1)N	26084539
		CHEMBL595180	3682	10	None	-83	4	Human	6.0	pKi	>	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	366	4	2	6	2.7	CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(n1)N	26084539
		3012003	216145	0	None	-6	12	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	311	5	0	3	3.8	CN1CCC(C(C1)COC2=CC=C(C=C2)OC)C3=CC=CC=C3	None
		134	2514	24	None	-933	67	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	None	-933	67	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	None	-933	67	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	None	-933	67	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	None	-933	67	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		202	1508	77	None	-1	30	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		60835	1508	77	None	-1	30	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		972	1508	77	None	-1	30	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		CHEMBL1175	1508	77	None	-1	30	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		DB00476	1508	77	None	-1	30	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		146570	43454	67	None	-1	4	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	324	5	0	3	3.8	CN(C)CCC[C@@]1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL1508	43454	67	None	-1	4	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	324	5	0	3	3.8	CN(C)CCC[C@@]1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		12057539	208041	42	None	-676	20	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	208041	42	None	-676	20	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	208041	42	None	-676	20	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		5281878	1660	35	None	-1	17	Human	8.0	pKi	None	8.0	Binding	NoneNone	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281881	1660	35	None	-1	17	Human	8.0	pKi	None	8.0	Binding	NoneNone	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		948	1660	35	None	-1	17	Human	8.0	pKi	None	8.0	Binding	NoneNone	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		968	1660	35	None	-1	17	Human	8.0	pKi	None	8.0	Binding	NoneNone	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL42055	1660	35	None	-1	17	Human	8.0	pKi	None	8.0	Binding	NoneNone	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL54661	1660	35	None	-1	17	Human	8.0	pKi	None	8.0	Binding	NoneNone	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00875	1660	35	None	-1	17	Human	8.0	pKi	None	8.0	Binding	NoneNone	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		1197	88	120	None	-	1	Human	3.7	pKi	None	3.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	122	2	1	2	0.6	NCCc1ccccn1	15206929
		75919	88	120	None	-	1	Human	3.7	pKi	None	3.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	122	2	1	2	0.6	NCCc1ccccn1	15206929
		CHEMBL32813	88	120	None	-	1	Human	3.7	pKi	None	3.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	122	2	1	2	0.6	NCCc1ccccn1	15206929
		1200	3963	2	None	-39	3	Human	4.4	pKi	None	4.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	335	8	4	5	0.7	O=C(NC(=NCCCc1cnc[nH]1)N)CSCc1nc[nH]c1C	16394198
		25149519	3963	2	None	-39	3	Human	4.4	pKi	None	4.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	335	8	4	5	0.7	O=C(NC(=NCCCc1cnc[nH]1)N)CSCc1nc[nH]c1C	16394198
		CHEMBL513056	3963	2	None	-39	3	Human	4.4	pKi	None	4.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	335	8	4	5	0.7	O=C(NC(=NCCCc1cnc[nH]1)N)CSCc1nc[nH]c1C	16394198
		1199	2976	0	None	-316	3	Human	4.5	pKi	None	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	8	3	4	2.5	NC(=NCCCc1[nH]cnc1)NC(=O)CC(c1ccccn1)c1ccc(cc1)F	16394198
		25149244	2976	0	None	-316	3	Human	4.5	pKi	None	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	8	3	4	2.5	NC(=NCCCc1[nH]cnc1)NC(=O)CC(c1ccccn1)c1ccc(cc1)F	16394198
		CHEMBL472273	2976	0	None	-316	3	Human	4.5	pKi	None	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	8	3	4	2.5	NC(=NCCCc1[nH]cnc1)NC(=O)CC(c1ccccn1)c1ccc(cc1)F	16394198
		1198	3962	1	None	-	1	Human	4.7	pKi	None	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	401	8	4	4	2.0	O=C(CC(c1ccc(c(c1)F)F)c1ncc[nH]1)NC(=NCCCc1cnc[nH]1)N	16394198
		25149704	3962	1	None	-	1	Human	4.7	pKi	None	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	401	8	4	4	2.0	O=C(CC(c1ccc(c(c1)F)F)c1ncc[nH]1)NC(=NCCCc1cnc[nH]1)N	16394198
		CHEMBL470563	3962	1	None	-	1	Human	4.7	pKi	None	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	401	8	4	4	2.0	O=C(CC(c1ccc(c(c1)F)F)c1ncc[nH]1)NC(=NCCCc1cnc[nH]1)N	16394198
		1201	3964	1	None	-2	2	Human	4.7	pKi	None	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	7	3	3	2.6	O=C(CC(c1ccccc1)c1ccccc1)NC(=NCCc1cnc[nH]1)N	16394198
		25150700	3964	1	None	-2	2	Human	4.7	pKi	None	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	7	3	3	2.6	O=C(CC(c1ccccc1)c1ccccc1)NC(=NCCc1cnc[nH]1)N	16394198
		CHEMBL499301	3964	1	None	-2	2	Human	4.7	pKi	None	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	7	3	3	2.6	O=C(CC(c1ccccc1)c1ccccc1)NC(=NCCc1cnc[nH]1)N	16394198
		1226	2019	20	None	-354	6	Human	5.2	pKi	None	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	16394198
		41376	2019	20	None	-354	6	Human	5.2	pKi	None	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	16394198
		CHEMBL12608	2019	20	None	-354	6	Human	5.2	pKi	None	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	9	4	4	1.2	NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C	16394198
		1202	3965	1	None	-	1	Human	5.2	pKi	None	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	411	8	3	3	3.3	O=C(CC(c1ccc(cc1)F)c1ccc(cc1)F)NC(=NCCCc1cnc[nH]1)N	16394198
		25150704	3965	1	None	-	1	Human	5.2	pKi	None	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	411	8	3	3	3.3	O=C(CC(c1ccc(cc1)F)c1ccc(cc1)F)NC(=NCCCc1cnc[nH]1)N	16394198
		CHEMBL513883	3965	1	None	-	1	Human	5.2	pKi	None	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	411	8	3	3	3.3	O=C(CC(c1ccc(cc1)F)c1ccc(cc1)F)NC(=NCCCc1cnc[nH]1)N	16394198
		1204	1932	119	None	-501	24	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	12065734
		1204	1932	119	None	-501	24	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	12626648
		1204	1932	119	None	-501	24	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	15206929
		1204	1932	119	None	-501	24	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	16394198
		1204	1932	119	None	-501	24	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	7925364
		1247	1932	119	None	-501	24	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	12065734
		1247	1932	119	None	-501	24	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	12626648
		1247	1932	119	None	-501	24	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	15206929
		1247	1932	119	None	-501	24	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	16394198
		1247	1932	119	None	-501	24	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	7925364
		1375	1932	119	None	-501	24	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	12065734
		1375	1932	119	None	-501	24	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	12626648
		1375	1932	119	None	-501	24	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	15206929
		1375	1932	119	None	-501	24	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	16394198
		1375	1932	119	None	-501	24	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	7925364
		774	1932	119	None	-501	24	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	12065734
		774	1932	119	None	-501	24	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	12626648
		774	1932	119	None	-501	24	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	15206929
		774	1932	119	None	-501	24	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	16394198
		774	1932	119	None	-501	24	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	7925364
		CHEMBL90	1932	119	None	-501	24	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	12065734
		CHEMBL90	1932	119	None	-501	24	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	12626648
		CHEMBL90	1932	119	None	-501	24	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	15206929
		CHEMBL90	1932	119	None	-501	24	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	16394198
		CHEMBL90	1932	119	None	-501	24	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	7925364
		DB05381	1932	119	None	-501	24	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	12065734
		DB05381	1932	119	None	-501	24	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	12626648
		DB05381	1932	119	None	-501	24	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	15206929
		DB05381	1932	119	None	-501	24	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	16394198
		DB05381	1932	119	None	-501	24	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	111	2	2	2	-0.1	NCCc1cnc[nH]1	7925364
		1193	44	0	None	-	1	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	128	2	1	3	0.6	NCCc1nccs1	12626648
		87653	44	0	None	-	1	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	128	2	1	3	0.6	NCCc1nccs1	12626648
		CHEMBL25414	44	0	None	-	1	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	128	2	1	3	0.6	NCCc1nccs1	12626648
		10389213	197	12	None	-6025	3	Human	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	453	10	1	6	2.6	O=C([C@H](NC(=O)c1ccco1)C)N1CCN(CC1)CCCOc1ccc(cc1)C(=O)C1CC1	12606603
		10389213	197	12	None	-6025	3	Human	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	453	10	1	6	2.6	O=C([C@H](NC(=O)c1ccco1)C)N1CCN(CC1)CCCOc1ccc(cc1)C(=O)C1CC1	15294456
		1216	197	12	None	-6025	3	Human	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	453	10	1	6	2.6	O=C([C@H](NC(=O)c1ccco1)C)N1CCN(CC1)CCCOc1ccc(cc1)C(=O)C1CC1	12606603
		1216	197	12	None	-6025	3	Human	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	453	10	1	6	2.6	O=C([C@H](NC(=O)c1ccco1)C)N1CCN(CC1)CCCOc1ccc(cc1)C(=O)C1CC1	15294456
		CHEMBL361355	197	12	None	-6025	3	Human	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	453	10	1	6	2.6	O=C([C@H](NC(=O)c1ccco1)C)N1CCN(CC1)CCCOc1ccc(cc1)C(=O)C1CC1	12606603
		CHEMBL361355	197	12	None	-6025	3	Human	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	453	10	1	6	2.6	O=C([C@H](NC(=O)c1ccco1)C)N1CCN(CC1)CCCOc1ccc(cc1)C(=O)C1CC1	15294456
		1217	199	0	None	-6309	3	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	9	0	8	0.5	CO[C@H]([C@H]([C@H](C(OC(=O)C)[2H])OC(=O)C)OC)[C@@H](OC(=O)C)C	15294456
		15608077	199	0	None	-6309	3	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	9	0	8	0.5	CO[C@H]([C@H]([C@H](C(OC(=O)C)[2H])OC(=O)C)OC)[C@@H](OC(=O)C)C	15294456
		1223	953	41	None	-14125	11	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	12606603
		2790	953	41	None	-14125	11	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	12606603
		CHEMBL14690	953	41	None	-14125	11	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	12606603
		2181	3128	46	None	-269	35	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	8935801
		4830	3128	46	None	-269	35	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	8935801
		92	3128	46	None	-269	35	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	8935801
		CHEMBL440294	3128	46	None	-269	35	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	8935801
		DB09286	3128	46	None	-269	35	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	8935801
		1194	45	3	None	-2089	4	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	265	3	2	2	2.3	NCCc1cnc([nH]1)c1cccc(c1)Br	12626648
		23786499	45	3	None	-2089	4	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	265	3	2	2	2.3	NCCc1cnc([nH]1)c1cccc(c1)Br	12626648
		CHEMBL26116	45	3	None	-2089	4	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	265	3	2	2	2.3	NCCc1cnc([nH]1)c1cccc(c1)Br	12626648
		1195	46	5	None	-	1	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	221	3	2	2	2.2	NCCc1cnc([nH]1)c1cccc(c1)Cl	12626648
		14827778	46	5	None	-	1	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	221	3	2	2	2.2	NCCc1cnc([nH]1)c1cccc(c1)Cl	12626648
		CHEMBL287052	46	5	None	-	1	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	221	3	2	2	2.2	NCCc1cnc([nH]1)c1cccc(c1)Cl	12626648
		1830	2590	44	None	-125	28	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	12629531
		207	2590	44	None	-125	28	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	12629531
		23897	2590	44	None	-125	28	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	12629531
		CHEMBL460	2590	44	None	-125	28	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	12629531
		DB01618	2590	44	None	-125	28	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	12629531
		10245039	49	0	None	-	1	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	313	3	2	2	2.2	NCCc1cnc([nH]1)c1cccc(c1)I	12626648
		1196	49	0	None	-	1	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	313	3	2	2	2.2	NCCc1cnc([nH]1)c1cccc(c1)I	12626648
		CHEMBL287367	49	0	None	-	1	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	313	3	2	2	2.2	NCCc1cnc([nH]1)c1cccc(c1)I	12626648
		1218	229	52	None	-891	4	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	330	4	0	3	5.0	N#Cc1ccc(cc1)c1ccc2c(c1)cc(o2)CCN1CCC[C@H]1C	15608078
		9818903	229	52	None	-891	4	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	330	4	0	3	5.0	N#Cc1ccc(cc1)c1ccc2c(c1)cc(o2)CCN1CCC[C@H]1C	15608078
		CHEMBL351231	229	52	None	-891	4	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	330	4	0	3	5.0	N#Cc1ccc(cc1)c1ccc2c(c1)cc(o2)CCN1CCC[C@H]1C	15608078
		1353	1911	93	None	-489	83	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	12629531
		1353	1911	93	None	-489	83	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8935801
		3559	1911	93	None	-489	83	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	12629531
		3559	1911	93	None	-489	83	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8935801
		86	1911	93	None	-489	83	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	12629531
		86	1911	93	None	-489	83	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8935801
		CHEMBL54	1911	93	None	-489	83	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	12629531
		CHEMBL54	1911	93	None	-489	83	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8935801
		DB00502	1911	93	None	-489	83	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	12629531
		DB00502	1911	93	None	-489	83	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8935801
		16362	3125	71	None	-489	30	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	12629531
		2172	3125	71	None	-489	30	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	12629531
		90	3125	71	None	-489	30	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	12629531
		CHEMBL1423	3125	71	None	-489	30	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	12629531
		DB01100	3125	71	None	-489	30	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	12629531
		10042467	1426	1	None	-173	3	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	333	8	1	2	4.3	CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C	12626648
		1203	1426	1	None	-173	3	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	333	8	1	2	4.3	CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C	12626648
		CHEMBL11553	1426	1	None	-173	3	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	333	8	1	2	4.3	CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C	12626648
		1221	475	9	None	-12	3	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	380	9	3	3	3.0	NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)F	12626648
		1221	475	9	None	-12	3	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	380	9	3	3	3.0	NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)F	16394198
		65895	475	9	None	-12	3	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	380	9	3	3	3.0	NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)F	12626648
		65895	475	9	None	-12	3	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	380	9	3	3	3.0	NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)F	16394198
		CHEMBL293802	475	9	None	-12	3	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	380	9	3	3	3.0	NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)F	12626648
		CHEMBL293802	475	9	None	-12	3	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	380	9	3	3	3.0	NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)F	16394198
		1219	737	0	None	-3	2	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	396	9	3	3	3.5	NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)Cl	12626648
		14660352	737	0	None	-3	2	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	396	9	3	3	3.5	NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)Cl	12626648
		CHEMBL304239	737	0	None	-3	2	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	396	9	3	3	3.5	NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)Cl	12626648
		1208	1985	0	None	-	1	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	251	2	0	1	3.7	CN([C@H]1Cc2ccccc2[C@H](C1)c1ccccc1)C	12065734
		15657195	1985	0	None	-	1	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	251	2	0	1	3.7	CN([C@H]1Cc2ccccc2[C@H](C1)c1ccccc1)C	12065734
		2435	3590	83	None	-95	48	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	12629531
		2435	3590	83	None	-95	48	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	8935801
		60149	3590	83	None	-95	48	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	12629531
		60149	3590	83	None	-95	48	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	8935801
		98	3590	83	None	-95	48	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	12629531
		98	3590	83	None	-95	48	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	8935801
		CHEMBL12713	3590	83	None	-95	48	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	12629531
		CHEMBL12713	3590	83	None	-95	48	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	8935801
		DB06144	3590	83	None	-95	48	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	12629531
		DB06144	3590	83	None	-95	48	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	8935801
		214	3860	58	None	-43	30	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	12629531
		2740	3860	58	None	-43	30	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	12629531
		5566	3860	58	None	-43	30	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	12629531
		66064	3860	58	None	-43	30	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	12629531
		CHEMBL422	3860	58	None	-43	30	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	12629531
		DB00831	3860	58	None	-43	30	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	12629531
		10106214	2103	1	None	-5	5	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	251	2	0	1	3.7	CN([C@@H]1Cc2ccccc2[C@H](C1)c1ccccc1)C	12065734
		1207	2103	1	None	-5	5	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	251	2	0	1	3.7	CN([C@@H]1Cc2ccccc2[C@H](C1)c1ccccc1)C	12065734
		1209	2103	1	None	-5	5	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	251	2	0	1	3.7	CN([C@@H]1Cc2ccccc2[C@H](C1)c1ccccc1)C	12065734
		CHEMBL127307	2103	1	None	-5	5	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	251	2	0	1	3.7	CN([C@@H]1Cc2ccccc2[C@H](C1)c1ccccc1)C	12065734
		475100	189	0	None	-31	6	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	4	1	7	2.6	OC1CCc2n(C1)c(=O)c(c(n2)C)CCN1CCC(CC1)c1noc2c1ccc(c2)F	8935801
		67	189	0	None	-31	6	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	4	1	7	2.6	OC1CCc2n(C1)c(=O)c(c(n2)C)CCN1CCC(CC1)c1noc2c1ccc(c2)F	8935801
		CHEMBL3542429	189	0	None	-31	6	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	4	1	7	2.6	OC1CCc2n(C1)c(=O)c(c(n2)C)CCN1CCC(CC1)c1noc2c1ccc(c2)F	8935801
		242	470	124	None	-22	51	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	12629531
		34	470	124	None	-22	51	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	12629531
		60795	470	124	None	-22	51	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	12629531
		CHEMBL1112	470	124	None	-22	51	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	12629531
		DB01238	470	124	None	-22	51	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	12629531
		2865	4143	73	None	-58	53	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	12629531
		2865	4143	73	None	-58	53	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	8935801
		59	4143	73	None	-58	53	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	12629531
		59	4143	73	None	-58	53	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	8935801
		60854	4143	73	None	-58	53	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	12629531
		60854	4143	73	None	-58	53	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	8935801
		CHEMBL708	4143	73	None	-58	53	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	12629531
		CHEMBL708	4143	73	None	-58	53	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	8935801
		DB00246	4143	73	None	-58	53	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	12629531
		DB00246	4143	73	None	-58	53	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	8935801
		2389	3331	118	None	-46	67	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	12629531
		2389	3331	118	None	-46	67	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	8935801
		5073	3331	118	None	-46	67	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	12629531
		5073	3331	118	None	-46	67	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	8935801
		96	3331	118	None	-46	67	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	12629531
		96	3331	118	None	-46	67	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	8935801
		CHEMBL85	3331	118	None	-46	67	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	12629531
		CHEMBL85	3331	118	None	-46	67	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	8935801
		DB00734	3331	118	None	-46	67	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	12629531
		DB00734	3331	118	None	-46	67	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	8935801
		1212	1662	50	None	-41	65	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	12629531
		204	1662	50	None	-41	65	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	12629531
		3372	1662	50	None	-41	65	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	12629531
		CHEMBL726	1662	50	None	-41	65	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	12629531
		DB00623	1662	50	None	-41	65	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	12629531
		100	3805	58	None	-7	55	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	12629531
		2637	3805	58	None	-7	55	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	12629531
		5452	3805	58	None	-7	55	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	12629531
		CHEMBL479	3805	58	None	-7	55	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	12629531
		DB00679	3805	58	None	-7	55	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	12629531
		10037815	3141	0	None	-	1	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	251	2	0	1	3.7	CN([C@@H]1Cc2ccccc2[C@@H](C1)c1ccccc1)C	12065734
		1206	3141	0	None	-	1	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	251	2	0	1	3.7	CN([C@@H]1Cc2ccccc2[C@@H](C1)c1ccccc1)C	12065734
		CHEMBL340199	3141	0	None	-	1	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	251	2	0	1	3.7	CN([C@@H]1Cc2ccccc2[C@@H](C1)c1ccccc1)C	12065734
		1222	1664	49	None	-17	33	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8935801
		3396	1664	49	None	-17	33	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8935801
		85	1664	49	None	-17	33	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8935801
		CHEMBL46516	1664	49	None	-17	33	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8935801
		DB04842	1664	49	None	-17	33	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8935801
		209	3057	97	None	-11	23	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	12629531
		2113	3057	97	None	-11	23	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	12629531
		4748	3057	97	None	-11	23	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	12629531
		CHEMBL567	3057	97	None	-11	23	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	12629531
		DB00850	3057	97	None	-11	23	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	12629531
		10037815	3141	0	None	-	1	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	251	2	0	1	3.7	CN([C@@H]1Cc2ccccc2[C@@H](C1)c1ccccc1)C	12065734
		1206	3141	0	None	-	1	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	251	2	0	1	3.7	CN([C@@H]1Cc2ccccc2[C@@H](C1)c1ccccc1)C	12065734
		CHEMBL340199	3141	0	None	-	1	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	251	2	0	1	3.7	CN([C@@H]1Cc2ccccc2[C@@H](C1)c1ccccc1)C	12065734
		2726	919	68	None	-2	72	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	12629531
		621	919	68	None	-2	72	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	12629531
		83	919	68	None	-2	72	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	12629531
		CHEMBL71	919	68	None	-2	72	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	12629531
		DB00477	919	68	None	-2	72	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	12629531
		1613	2348	53	None	-3	44	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	12629531
		205	2348	53	None	-3	44	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	12629531
		3964	2348	53	None	-3	44	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	12629531
		CHEMBL831	2348	53	None	-3	44	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	12629531
		DB00408	2348	53	None	-3	44	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	12629531
		2337	3256	77	None	1	62	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	12629531
		2337	3256	77	None	1	62	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	8935801
		50	3256	77	None	1	62	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	12629531
		50	3256	77	None	1	62	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	8935801
		5002	3256	77	None	1	62	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	12629531
		5002	3256	77	None	1	62	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	8935801
		CHEMBL716	3256	77	None	1	62	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	12629531
		CHEMBL716	3256	77	None	1	62	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	8935801
		DB01224	3256	77	None	1	62	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	12629531
		DB01224	3256	77	None	1	62	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	8935801
		212	3806	47	None	-5	25	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	12629531
		2639	3806	47	None	-5	25	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	12629531
		941651	3806	47	None	-5	25	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	12629531
		CHEMBL1201	3806	47	None	-5	25	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	12629531
		DB01623	3806	47	None	-5	25	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	12629531
		10106214	2103	1	None	-5	5	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	251	2	0	1	3.7	CN([C@@H]1Cc2ccccc2[C@H](C1)c1ccccc1)C	12065734
		1207	2103	1	None	-5	5	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	251	2	0	1	3.7	CN([C@@H]1Cc2ccccc2[C@H](C1)c1ccccc1)C	12065734
		1209	2103	1	None	-5	5	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	251	2	0	1	3.7	CN([C@@H]1Cc2ccccc2[C@H](C1)c1ccccc1)C	12065734
		CHEMBL127307	2103	1	None	-5	5	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	251	2	0	1	3.7	CN([C@@H]1Cc2ccccc2[C@H](C1)c1ccccc1)C	12065734
		10015055	2104	4	None	15	5	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	251	2	0	1	3.7	CN([C@H]1Cc2ccccc2[C@@H](C1)c1ccccc1)C	12065734
		1212	2104	4	None	15	5	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	251	2	0	1	3.7	CN([C@H]1Cc2ccccc2[C@@H](C1)c1ccccc1)C	12065734
		CHEMBL3402679	2104	4	None	15	5	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	251	2	0	1	3.7	CN([C@H]1Cc2ccccc2[C@@H](C1)c1ccccc1)C	12065734
		135398745	2914	112	None	1	65	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	12629531
		135398745	2914	112	None	1	65	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	8935801
		47	2914	112	None	1	65	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	12629531
		47	2914	112	None	1	65	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	8935801
		CHEMBL715	2914	112	None	1	65	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	12629531
		CHEMBL715	2914	112	None	1	65	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	8935801
		DB00334	2914	112	None	1	65	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	12629531
		DB00334	2914	112	None	1	65	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	8935801
		135398737	958	93	None	2	89	Human	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	12065734
		135398737	958	93	None	2	89	Human	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	12629531
		135398737	958	93	None	2	89	Human	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8935801
		38	958	93	None	2	89	Human	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	12065734
		38	958	93	None	2	89	Human	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	12629531
		38	958	93	None	2	89	Human	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8935801
		722	958	93	None	2	89	Human	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	12065734
		722	958	93	None	2	89	Human	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	12629531
		722	958	93	None	2	89	Human	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8935801
		CHEMBL42	958	93	None	2	89	Human	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	12065734
		CHEMBL42	958	93	None	2	89	Human	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	12629531
		CHEMBL42	958	93	None	2	89	Human	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8935801
		DB00363	958	93	None	2	89	Human	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	12065734
		DB00363	958	93	None	2	89	Human	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	12629531
		DB00363	958	93	None	2	89	Human	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8935801
		103	4153	61	None	-1	53	Human	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	8935801
		2875	4153	61	None	-1	53	Human	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	8935801
		5736	4153	61	None	-1	53	Human	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	8935801
		CHEMBL285802	4153	61	None	-1	53	Human	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	8935801
		DB09225	4153	61	None	-1	53	Human	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	8935801
		1225	1471	26	None	-1	22	Human	9.8	pKi	None	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	12065734
		3958	1471	26	None	-1	22	Human	9.8	pKi	None	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	12065734
		667477	1471	26	None	-1	22	Human	9.8	pKi	None	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	12065734
		CHEMBL860	1471	26	None	-1	22	Human	9.8	pKi	None	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	12065734
		DB01142	1471	26	None	-1	22	Human	9.8	pKi	None	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	12065734
		163091	494	34	None	-6	10	Human	9.8	pKi	None	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	0	0	2	4.3	Clc1ccc2c(c1)[C@H]1CN(C[C@@H]1c1c(O2)cccc1)C	8935801
		22	494	34	None	-6	10	Human	9.8	pKi	None	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	0	0	2	4.3	Clc1ccc2c(c1)[C@H]1CN(C[C@@H]1c1c(O2)cccc1)C	8935801
		CHEMBL504548	494	34	None	-6	10	Human	9.8	pKi	None	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	0	0	2	4.3	Clc1ccc2c(c1)[C@H]1CN(C[C@@H]1c1c(O2)cccc1)C	8935801

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Ligand source activities (1 row/activity)